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Disease Ontology (DO): disease of cellular proliferation
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: DO Hierarchy (disease ontology from University of Maryland)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this DO term (Not in SDDO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Saposin | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Triple coiled coil domain of C-type lectins | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Uteroglobin-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Acid proteases | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00002519 | DIRECT |
| Protein kinase-like (PK-like) | 0.00005551 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0006067 | DIRECT |
| SH2 domain | 0.001154 | INHERITED FROM: chronic myeloid leukemia || breast cancer || organ system cancer || in situ carcinoma || myelodysplastic/myeloproliferative neoplasm |
| Integrin domains | 0.002616 | INHERITED FROM: multiple myeloma || breast cancer |
| Cystine-knot cytokines | 0.00874 | INHERITED FROM: rhabdomyosarcoma || neurilemmoma || myelofibrosis || reproductive organ cancer || prostate cancer || skeletal muscle cancer || benign neoplasm || neuroma |
| PGBD-like | 0.008817 | INHERITED FROM: ovary epithelial cancer || carcinoma || bile duct adenocarcinoma || liver carcinoma || endometrial cancer || ovarian cancer || adult astrocytic tumour || integumentary system cancer || renal carcinoma || renal cell carcinoma || pancreatic ductal adenocarcinoma || cell type cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || astrocytoma || salivary gland adenoid cystic carcinoma || kidney cancer || cell type benign neoplasm || oral cavity cancer || head and neck squamous cell carcinoma || breast cancer || chondrosarcoma || myeloid neoplasm |
| Leucine zipper domain | 0.008986 | INHERITED FROM: hematologic cancer |
| Ubiquitin-like | 0.009963 | INHERITED FROM: pilocytic astrocytoma |
| TIMP-like | 0.01195 | INHERITED FROM: renal carcinoma || bone marrow cancer || myeloid neoplasm |
| SAM/Pointed domain | 0.01567 | INHERITED FROM: invasive ductal carcinoma |
| Growth factor receptor domain | 0.01772 | INHERITED FROM: urinary system cancer || liver carcinoma || skin hemangioma || large intestine cancer || neurofibroma || malignant glioma || peripheral nerve sheath neoplasm || kidney cancer || colorectal cancer |
| HMG-box | 0.01814 | INHERITED FROM: embryonal cancer || seminoma |
| HLH, helix-loop-helix DNA-binding domain | 0.01819 | INHERITED FROM: autonomic nervous system neoplasm |
| Arginase/deacetylase | 0.02123 | INHERITED FROM: Hodgkin's lymphoma |
| Caspase-like | 0.02123 | INHERITED FROM: melanoma |
| Cyclin-like | 0.02294 | INHERITED FROM: sensory system cancer || retinal cancer || retinal cell cancer || laryngeal carcinoma |
| 4-helical cytokines | 0.03709 | INHERITED FROM: immune system cancer || Sezary's disease || placenta cancer || hematologic cancer || organ system cancer || myeloid neoplasm |
| Bcl-2 inhibitors of programmed cell death | 0.03819 | INHERITED FROM: carcinoma || connective tissue cancer || osteosarcoma || chronic lymphocytic leukemia || gastric adenocarcinoma || organ system cancer || stomach carcinoma |
| Frizzled cysteine-rich domain | 0.04612 | INHERITED FROM: multiple myeloma || myeloid neoplasm |
| TNF receptor-like | 0.04617 | INHERITED FROM: immune system cancer || pancreatic adenocarcinoma || breast cancer || hematologic cancer || breast carcinoma || myeloid neoplasm |
| Hemopexin-like domain | 0.05805 | INHERITED FROM: ovary epithelial cancer || carcinoma || endometrial cancer || ovarian cancer || adult astrocytic tumour || integumentary system cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || salivary gland adenoid cystic carcinoma || bone marrow cancer || meningioma || chondrosarcoma || myeloid neoplasm |
| FnI-like domain | 0.05805 | INHERITED FROM: neurofibroma || peripheral nerve sheath neoplasm |
| Snake toxin-like | 0.05805 | INHERITED FROM: retinal cancer || retinal cell cancer |
| Thyroglobulin type-1 domain | 0.05934 | INHERITED FROM: renal carcinoma || renal cell carcinoma || kidney cancer |
| SOCS box-like | 0.06789 | INHERITED FROM: pre-malignant neoplasm || chronic myeloid leukemia || in situ carcinoma |
| Metalloproteases ("zincins"), catalytic domain | 0.06859 | INHERITED FROM: endometrial cancer || adult astrocytic tumour || integumentary system cancer || cell type cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || salivary gland adenoid cystic carcinoma || oral cavity cancer || breast cancer || chondrosarcoma |
| Ran binding protein zinc finger-like | 0.09692 | INHERITED FROM: sensory system cancer || sarcoma || retinal cancer || retinal cell cancer |
| Blood coagulation inhibitor (disintegrin) | 0.1237 | INHERITED FROM: skin carcinoma || basal cell carcinoma |
| Galactose-binding domain-like | 0.1591 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Lipoxigenase | 0.214 | INHERITED FROM: adenoma || cell type benign neoplasm || benign neoplasm |
| Immunoglobulin | 0.2343 | INHERITED FROM: immune system cancer || endometrial stromal sarcoma || fibrosarcoma of bone |
| Kringle-like | 0.2426 | INHERITED FROM: lung carcinoma || connective tissue cancer || invasive ductal carcinoma || thymoma || pancreatic ductal adenocarcinoma || thymus cancer || laryngeal carcinoma || meningioma || bone cancer || Hodgkin's lymphoma |
| Notch domain | 0.2812 | INHERITED FROM: lymphoblastic leukemia || urinary system cancer || liver carcinoma || hemangioma || skin hemangioma || organ system benign neoplasm || renal carcinoma || renal cell carcinoma || kidney cancer || liver cancer || cell type benign neoplasm || integumentary system benign neoplasm || benign neoplasm |
| Toll/Interleukin receptor TIR domain | 0.2817 | INHERITED FROM: mycosis fungoides || mature T-cell and NK-cell lymphoma |
| A DNA-binding domain in eukaryotic transcription factors | 0.3034 | INHERITED FROM: immune system cancer || hematologic cancer |
| Thioredoxin-like | 0.3207 | INHERITED FROM: oligodendroglioma |
| p53-like transcription factors | 0.3367 | INHERITED FROM: chronic leukemia || colon cancer || mammary Paget's disease || hemangioma || connective tissue cancer || head and neck cancer || breast adenocarcinoma || Burkitt lymphoma || head and neck carcinoma || salivary gland adenoid cystic carcinoma || laryngeal carcinoma || B-cell lymphoma |
| Nucleotide-diphospho-sugar transferases | 0.3367 | INHERITED FROM: prostate adenocarcinoma |
| Defensin-like | 0.3729 | INHERITED FROM: non-Hodgkin lymphoma || mycosis fungoides || mature T-cell and NK-cell lymphoma |
| Heme-dependent peroxidases | 0.3729 | INHERITED FROM: cell type benign neoplasm |
| Globin-like | 0.4284 | INHERITED FROM: pre-malignant neoplasm || in situ carcinoma |
| Prefoldin | 0.4328 | INHERITED FROM: neuroendocrine carcinoma || pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma |
| Ankyrin repeat | 0.4422 | INHERITED FROM: rhabdomyosarcoma || skin hemangioma || skeletal muscle cancer |
| Second domain of FERM | 0.4465 | INHERITED FROM: meningioma |
| Transcription factor STAT-4 N-domain | 0.4573 | INHERITED FROM: chronic leukemia || head and neck cancer || chronic myeloid leukemia || head and neck carcinoma |
| STAT | 0.4573 | INHERITED FROM: chronic leukemia || head and neck cancer || chronic myeloid leukemia || head and neck carcinoma |
| TSP-1 type 1 repeat | 0.4894 | INHERITED FROM: neurofibroma || peripheral nerve sheath neoplasm |
| MHC antigen-recognition domain | 0.5085 | INHERITED FROM: chronic myeloid leukemia || leukemia |
| Interleukin 8-like chemokines | 0.5532 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| ABC transporter transmembrane region | 0.6528 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| DNA repair protein MutS, domain III | 0.6652 | INHERITED FROM: urinary system cancer |
| TNF-like | 0.7108 | INHERITED FROM: Burkitt lymphoma || B-cell lymphoma || myeloid neoplasm |
| Family A G protein-coupled receptor-like | 0.7417 | INHERITED FROM: Conn's syndrome || ACTH-secreting pituitary adenoma |
| DPP6 N-terminal domain-like | 0.8375 | INHERITED FROM: chronic lymphocytic leukemia || central nervous system cancer || meningioma |
| alpha/beta-Hydrolases | 0.8839 | INHERITED FROM: central nervous system cancer || meningioma |
| Intermediate filament protein, coiled coil region | 0.9856 | INHERITED FROM: neuroendocrine carcinoma || pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma |
| HD-domain/PDEase-like | 1 | INHERITED FROM: chronic lymphocytic leukemia |
| SNARE fusion complex | 1 | INHERITED FROM: endocrine organ benign neoplasm || parathyroid adenoma |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Metallothionein | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Saposin | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| BAG domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Sialidases | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Polo-box domain | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Flavoproteins | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| HIT-like | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Insulin-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| GroES-like | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Proteasome activator | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Triple coiled coil domain of C-type lectins | 0 | Direct |
| DNA clamp | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| PAZ domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Uteroglobin-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| PP2C-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| ACP-like | 0 | Direct |
| BTG domain-like | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Acid proteases | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0.00002519 | Direct |
| Protein kinase-like (PK-like) | 0.00005551 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0006067 | Direct |
| SH2 domain | 0.001154 | Inherited |
| Integrin domains | 0.002616 | Inherited |
| Cystine-knot cytokines | 0.00874 | Inherited |
| PGBD-like | 0.008817 | Inherited |
| Leucine zipper domain | 0.008986 | Inherited |
| Ubiquitin-like | 0.009963 | Inherited |
| TIMP-like | 0.01195 | Inherited |
| SAM/Pointed domain | 0.01567 | Inherited |
| Growth factor receptor domain | 0.01772 | Inherited |
| HMG-box | 0.01814 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01819 | Inherited |
| Arginase/deacetylase | 0.02123 | Inherited |
| Caspase-like | 0.02123 | Inherited |
| Cyclin-like | 0.02294 | Inherited |
| 4-helical cytokines | 0.03709 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.03819 | Inherited |
| Frizzled cysteine-rich domain | 0.04612 | Inherited |
| TNF receptor-like | 0.04617 | Inherited |
| Hemopexin-like domain | 0.05805 | Inherited |
| FnI-like domain | 0.05805 | Inherited |
| Snake toxin-like | 0.05805 | Inherited |
| Thyroglobulin type-1 domain | 0.05934 | Inherited |
| SOCS box-like | 0.06789 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.06859 | Inherited |
| Ran binding protein zinc finger-like | 0.09692 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.1237 | Inherited |
| Galactose-binding domain-like | 0.1591 | Inherited |
| Lipoxigenase | 0.214 | Inherited |
| Immunoglobulin | 0.2343 | Inherited |
| Kringle-like | 0.2426 | Inherited |
| Notch domain | 0.2812 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2817 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.3034 | Inherited |
| Thioredoxin-like | 0.3207 | Inherited |
| p53-like transcription factors | 0.3367 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.3367 | Inherited |
| Defensin-like | 0.3729 | Inherited |
| Heme-dependent peroxidases | 0.3729 | Inherited |
| Globin-like | 0.4284 | Inherited |
| Prefoldin | 0.4328 | Inherited |
| Ankyrin repeat | 0.4422 | Inherited |
| Second domain of FERM | 0.4465 | Inherited |
| Transcription factor STAT-4 N-domain | 0.4573 | Inherited |
| STAT | 0.4573 | Inherited |
| TSP-1 type 1 repeat | 0.4894 | Inherited |
| MHC antigen-recognition domain | 0.5085 | Inherited |
| Interleukin 8-like chemokines | 0.5532 | Inherited |
| ABC transporter transmembrane region | 0.6528 | Inherited |
| DNA repair protein MutS, domain III | 0.6652 | Inherited |
| TNF-like | 0.7108 | Inherited |
| Family A G protein-coupled receptor-like | 0.7417 | Inherited |
| DPP6 N-terminal domain-like | 0.8375 | Inherited |
| alpha/beta-Hydrolases | 0.8839 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9856 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| SNARE fusion complex | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this DO term (Not in SDDO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| UDPGT-like | 0 | DIRECT |
| Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Ricin B-like | 0 | DIRECT |
| Prokaryotic proteases | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| STAR domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| DIX domain | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Bee venom hyaluronidase | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Sialidases (neuraminidases) | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| AlkB-like | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| SCAN domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| C2 set domains | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Triple coiled coil domain of C-type lectins | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| Arginase-like amidino hydrolases | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| Uteroglobin-like | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| CAD domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| GABARAP-like | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Aldo-keto reductases (NADP) | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Methyl-CpG-binding domain, MBD | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| Integrin beta EGF-like domains | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Cystatins | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| HtrA-like serine proteases | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Fatty acid binding protein-like | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00002035 | DIRECT |
| Nuclear receptor | 0.00003882 | DIRECT |
| Protein kinases, catalytic subunit | 0.00006145 | DIRECT |
| SH2 domain | 0.001009 | INHERITED FROM: chronic myeloid leukemia || organ system cancer || in situ carcinoma || myelodysplastic/myeloproliferative neoplasm |
| Growth factor receptor domain | 0.001129 | INHERITED FROM: ovary epithelial cancer || rhabdomyosarcoma || urinary system cancer || liver carcinoma || skin hemangioma || large intestine cancer || lung carcinoma || lung cancer || neurofibroma || osteosarcoma || cell type cancer || cancer || malignant glioma || peripheral nerve sheath neoplasm || skeletal muscle cancer || kidney cancer || colorectal cancer |
| Integrin domains | 0.001986 | INHERITED FROM: multiple myeloma || breast cancer |
| Matrix metalloproteases, catalytic domain | 0.002715 | INHERITED FROM: ovary epithelial cancer || carcinoma || bile duct adenocarcinoma || endometrial cancer || ovarian cancer || adult astrocytic tumour || integumentary system cancer || renal carcinoma || renal cell carcinoma || cell type cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || astrocytoma || salivary gland adenoid cystic carcinoma || kidney cancer || oral cavity cancer || head and neck squamous cell carcinoma || chondrosarcoma || myeloid neoplasm |
| MMP N-terminal domain | 0.00679 | INHERITED FROM: ovary epithelial cancer || carcinoma || bile duct adenocarcinoma || liver carcinoma || endometrial cancer || ovarian cancer || adult astrocytic tumour || integumentary system cancer || renal carcinoma || renal cell carcinoma || pancreatic ductal adenocarcinoma || cell type cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || astrocytoma || salivary gland adenoid cystic carcinoma || kidney cancer || cell type benign neoplasm || oral cavity cancer || head and neck squamous cell carcinoma || breast cancer || chondrosarcoma || myeloid neoplasm |
| Transforming growth factor (TGF)-beta | 0.007064 | INHERITED FROM: basal cell carcinoma || neurilemmoma || reproductive organ cancer || prostate cancer || benign neoplasm || neuroma |
| Leucine zipper domain | 0.007403 | INHERITED FROM: hematologic cancer |
| HMG-box | 0.01497 | INHERITED FROM: embryonal cancer || seminoma |
| HLH, helix-loop-helix DNA-binding domain | 0.01633 | INHERITED FROM: autonomic nervous system neoplasm |
| Cyclin | 0.02961 | INHERITED FROM: sensory system cancer || larynx cancer || retinal cancer || retinal cell cancer || laryngeal carcinoma |
| Caspase catalytic domain | 0.03093 | INHERITED FROM: melanoma |
| Bcl-2 inhibitors of programmed cell death | 0.03093 | INHERITED FROM: carcinoma || connective tissue cancer || osteosarcoma || leukemia || chronic lymphocytic leukemia || gastric adenocarcinoma || organ system cancer || stomach carcinoma |
| S100 proteins | 0.03093 | INHERITED FROM: lung carcinoma || organ system benign neoplasm || non-small cell lung carcinoma || cell type cancer || respiratory system cancer || breast cancer || organ system cancer |
| Frizzled cysteine-rich domain | 0.03863 | INHERITED FROM: multiple myeloma || myeloid leukemia || myeloid neoplasm |
| Histone deacetylase, HDAC | 0.0417 | INHERITED FROM: lymphoma || Hodgkin's lymphoma |
| Long-chain cytokines | 0.0417 | INHERITED FROM: thoracic cancer || female reproductive organ cancer || breast cancer |
| Hemopexin-like domain | 0.04943 | INHERITED FROM: ovary epithelial cancer || carcinoma || endometrial cancer || ovarian cancer || adult astrocytic tumour || integumentary system cancer || endometrial carcinoma || reproductive organ cancer || prostate cancer || salivary gland adenoid cystic carcinoma || bone marrow cancer || meningioma || chondrosarcoma || myeloid neoplasm |
| Thyroglobulin type-1 domain | 0.04998 | INHERITED FROM: retinal cancer || renal carcinoma || renal cell carcinoma || retinal cell cancer || kidney cancer |
| SOCS box-like | 0.05666 | INHERITED FROM: pre-malignant neoplasm || chronic myeloid leukemia || in situ carcinoma |
| SAM (sterile alpha motif) domain | 0.06174 | INHERITED FROM: invasive ductal carcinoma || endocrine gland cancer |
| Paired domain | 0.07623 | INHERITED FROM: rhabdomyosarcoma || skeletal muscle cancer || alveolar rhabdomyosarcoma |
| TNF receptor-like | 0.07805 | INHERITED FROM: immune system cancer || pancreatic cancer || pancreatic adenocarcinoma || breast cancer || hematologic cancer || breast carcinoma || myeloid neoplasm |
| Ran binding protein zinc finger-like | 0.08274 | INHERITED FROM: sensory system cancer || sarcoma || retinal cancer || retinal cell cancer |
| Blood coagulation inhibitor (disintegrin) | 0.1067 | INHERITED FROM: skin carcinoma || basal cell carcinoma || breast carcinoma |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.1067 | INHERITED FROM: bile duct adenocarcinoma || leukemia || astrocytoma || bile duct cancer || hematologic cancer |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.1356 | INHERITED FROM: colon cancer || hemangioma |
| Ephrin ectodomain | 0.1382 | INHERITED FROM: osteosarcoma || bone cancer |
| PB1 domain | 0.1382 | INHERITED FROM: breast cancer |
| ABC transporter transmembrane region | 0.1561 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| First domain of FERM | 0.1858 | INHERITED FROM: meningioma |
| Animal lipoxigenases | 0.1877 | INHERITED FROM: adenoma || cell type benign neoplasm || benign neoplasm |
| I set domains | 0.1979 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.2193 | INHERITED FROM: colon cancer || hemangioma || nasopharynx carcinoma |
| Fibronectin type II module | 0.2193 | INHERITED FROM: connective tissue cancer || thymoma || osteosarcoma || thymus cancer || thyroid carcinoma || thyroid cancer || head and neck squamous cell carcinoma || laryngeal carcinoma || bone cancer || Hodgkin's lymphoma || myeloid neoplasm |
| EGF-type module | 0.2228 | INHERITED FROM: histiocytoma |
| FHA domain | 0.2268 | INHERITED FROM: retinal cancer || retinal cell cancer |
| Notch domain | 0.2505 | INHERITED FROM: lymphoblastic leukemia || urinary system cancer || liver carcinoma || hemangioma || skin hemangioma || organ system benign neoplasm || renal carcinoma || renal cell carcinoma || kidney cancer || liver cancer || cell type benign neoplasm || integumentary system benign neoplasm || benign neoplasm |
| Lipoxigenase N-terminal domain | 0.2505 | INHERITED FROM: adenoma || cell type benign neoplasm |
| A DNA-binding domain in eukaryotic transcription factors | 0.2756 | INHERITED FROM: immune system cancer || hematologic cancer |
| Glutathione peroxidase-like | 0.2758 | INHERITED FROM: adenoma |
| Toll/Interleukin receptor TIR domain | 0.3053 | INHERITED FROM: mycosis fungoides || mature T-cell and NK-cell lymphoma |
| Hexokinase | 0.3364 | INHERITED FROM: adenocarcinoma |
| Nucleoside diphosphate kinase, NDK | 0.3364 | INHERITED FROM: myeloid leukemia |
| C1 set domains (antibody constant domain-like) | 0.3364 | INHERITED FROM: chronic leukemia || leukemia |
| Myeloperoxidase-like | 0.3427 | INHERITED FROM: cell type benign neoplasm |
| Defensin | 0.3427 | INHERITED FROM: non-Hodgkin lymphoma || mycosis fungoides || mature T-cell and NK-cell lymphoma |
| Second domain of FERM | 0.357 | INHERITED FROM: meningioma |
| Globins | 0.3992 | INHERITED FROM: pre-malignant neoplasm || in situ carcinoma |
| STAT | 0.4256 | INHERITED FROM: chronic leukemia || head and neck cancer || chronic myeloid leukemia || head and neck carcinoma |
| Transcription factor STAT-4 N-domain | 0.4256 | INHERITED FROM: chronic leukemia || head and neck cancer || chronic myeloid leukemia || head and neck carcinoma |
| STAT DNA-binding domain | 0.4256 | INHERITED FROM: chronic leukemia || head and neck cancer || chronic myeloid leukemia || head and neck carcinoma |
| Ankyrin repeat | 0.4274 | INHERITED FROM: rhabdomyosarcoma || skin hemangioma || skeletal muscle cancer |
| Third domain of FERM | 0.4323 | INHERITED FROM: meningioma |
| Kringle modules | 0.4367 | INHERITED FROM: invasive ductal carcinoma || pancreatic ductal adenocarcinoma |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4425 | INHERITED FROM: papillary carcinoma |
| TSP-1 type 1 repeat | 0.4715 | INHERITED FROM: neurofibroma || peripheral nerve sheath neoplasm |
| MHC antigen-recognition domain | 0.4878 | INHERITED FROM: chronic myeloid leukemia || leukemia |
| DPP6 N-terminal domain-like | 0.5187 | INHERITED FROM: nervous system cancer || chronic lymphocytic leukemia || central nervous system cancer || meningioma |
| Interleukin 8-like chemokines | 0.5353 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| Eukaryotic proteases | 0.5459 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Reprolysin-like | 0.5752 | INHERITED FROM: breast carcinoma |
| DPP6 catalytic domain-like | 0.6299 | INHERITED FROM: central nervous system cancer || meningioma |
| DNA repair protein MutS, domain III | 0.6299 | INHERITED FROM: urinary system cancer |
| TNF-like | 0.6892 | INHERITED FROM: Burkitt lymphoma || B-cell lymphoma || myeloid neoplasm |
| Rhodopsin-like | 0.7973 | INHERITED FROM: functioning pituitary adenoma || Conn's syndrome || ACTH-secreting pituitary adenoma |
| Interleukin-1 (IL-1) | 0.883 | INHERITED FROM: multiple myeloma || pancreatic cancer |
| ABC transporter ATPase domain-like | 0.9011 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| PDEase | 0.9015 | INHERITED FROM: lymphoblastic leukemia || chronic lymphocytic leukemia |
| Intermediate filament protein, coiled coil region | 0.9732 | INHERITED FROM: neuroendocrine carcinoma || pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma |
| SNARE fusion complex | 1 | INHERITED FROM: endocrine organ benign neoplasm || parathyroid adenoma |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Aconitase iron-sulfur domain | 0 | Direct |
| BAG domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| SRF-like | 0 | Direct |
| UDPGT-like | 0 | Direct |
| Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain | 0 | Direct |
| Annexin | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Ricin B-like | 0 | Direct |
| Prokaryotic proteases | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| Ephrin receptor ligand binding domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| STAR domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| DIX domain | 0 | Direct |
| Pepsin-like | 0 | Direct |
| Pointed domain | 0 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| BTG domain-like | 0 | Direct |
| DNA ligase | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Bee venom hyaluronidase | 0 | Direct |
| L domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Metallothionein | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Sialidases (neuraminidases) | 0 | Direct |
| PA domain | 0 | Direct |
| Transferrin | 0 | Direct |
| Neurotrophin | 0 | Direct |
| MutT-like | 0 | Direct |
| PAZ domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| AlkB-like | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| SCAN domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| ZZ domain | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| C2 set domains | 0 | Direct |
| PP2C-like | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Triple coiled coil domain of C-type lectins | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| Arginase-like amidino hydrolases | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| Uteroglobin-like | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| CAD domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| GABARAP-like | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| Adenain-like | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Aldo-keto reductases (NADP) | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Methyl-CpG-binding domain, MBD | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| Integrin beta EGF-like domains | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Cystatins | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| LeuD-like | 0 | Direct |
| HtrA-like serine proteases | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Fatty acid binding protein-like | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0.00002035 | Direct |
| Nuclear receptor | 0.00003882 | Direct |
| Protein kinases, catalytic subunit | 0.00006145 | Direct |
| SH2 domain | 0.001009 | Inherited |
| Growth factor receptor domain | 0.001129 | Inherited |
| Integrin domains | 0.001986 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.002715 | Inherited |
| MMP N-terminal domain | 0.00679 | Inherited |
| Transforming growth factor (TGF)-beta | 0.007064 | Inherited |
| Leucine zipper domain | 0.007403 | Inherited |
| HMG-box | 0.01497 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01633 | Inherited |
| Cyclin | 0.02961 | Inherited |
| Caspase catalytic domain | 0.03093 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.03093 | Inherited |
| S100 proteins | 0.03093 | Inherited |
| Frizzled cysteine-rich domain | 0.03863 | Inherited |
| Histone deacetylase, HDAC | 0.0417 | Inherited |
| Long-chain cytokines | 0.0417 | Inherited |
| Hemopexin-like domain | 0.04943 | Inherited |
| Thyroglobulin type-1 domain | 0.04998 | Inherited |
| SOCS box-like | 0.05666 | Inherited |
| SAM (sterile alpha motif) domain | 0.06174 | Inherited |
| Paired domain | 0.07623 | Inherited |
| TNF receptor-like | 0.07805 | Inherited |
| Ran binding protein zinc finger-like | 0.08274 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.1067 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.1067 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.1356 | Inherited |
| Ephrin ectodomain | 0.1382 | Inherited |
| PB1 domain | 0.1382 | Inherited |
| ABC transporter transmembrane region | 0.1561 | Inherited |
| First domain of FERM | 0.1858 | Inherited |
| Animal lipoxigenases | 0.1877 | Inherited |
| I set domains | 0.1979 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.2193 | Inherited |
| Fibronectin type II module | 0.2193 | Inherited |
| EGF-type module | 0.2228 | Inherited |
| FHA domain | 0.2268 | Inherited |
| Notch domain | 0.2505 | Inherited |
| Lipoxigenase N-terminal domain | 0.2505 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.2756 | Inherited |
| Glutathione peroxidase-like | 0.2758 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3053 | Inherited |
| Hexokinase | 0.3364 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.3364 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.3364 | Inherited |
| Myeloperoxidase-like | 0.3427 | Inherited |
| Defensin | 0.3427 | Inherited |
| Second domain of FERM | 0.357 | Inherited |
| Globins | 0.3992 | Inherited |
| STAT | 0.4256 | Inherited |
| Transcription factor STAT-4 N-domain | 0.4256 | Inherited |
| STAT DNA-binding domain | 0.4256 | Inherited |
| Ankyrin repeat | 0.4274 | Inherited |
| Third domain of FERM | 0.4323 | Inherited |
| Kringle modules | 0.4367 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4425 | Inherited |
| TSP-1 type 1 repeat | 0.4715 | Inherited |
| MHC antigen-recognition domain | 0.4878 | Inherited |
| DPP6 N-terminal domain-like | 0.5187 | Inherited |
| Interleukin 8-like chemokines | 0.5353 | Inherited |
| Eukaryotic proteases | 0.5459 | Inherited |
| Reprolysin-like | 0.5752 | Inherited |
| DPP6 catalytic domain-like | 0.6299 | Inherited |
| DNA repair protein MutS, domain III | 0.6299 | Inherited |
| TNF-like | 0.6892 | Inherited |
| Rhodopsin-like | 0.7973 | Inherited |
| Interleukin-1 (IL-1) | 0.883 | Inherited |
| ABC transporter ATPase domain-like | 0.9011 | Inherited |
| PDEase | 0.9015 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9732 | Inherited |
| SNARE fusion complex | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Triple coiled coil domain of C-type lectins | 0 | DIRECT |
| Saposin | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Acid proteases | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| Uteroglobin-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00001428 | DIRECT |
| Protein kinase-like (PK-like) | 0.00003208 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0003726 | DIRECT |
| SH2 domain | 0.0007314 | DIRECT |
| Integrin domains | 0.001723 | INHERITED FROM: multiple myeloma || breast cancer |
| Cystine-knot cytokines | 0.006017 | INHERITED FROM: neuroma || uterine benign neoplasm || myelofibrosis || reproductive organ cancer || prostate cancer || skeletal muscle cancer || female reproductive organ benign neoplasm || rhabdomyosarcoma || benign neoplasm || basal cell carcinoma || neurilemmoma |
| PGBD-like | 0.006077 | INHERITED FROM: oral cavity cancer || endometrial cancer || astrocytoma || connective tissue cancer || reproductive organ cancer || myeloid neoplasm || prostate cancer || chondrosarcoma || renal carcinoma || endometrial carcinoma || cell type cancer || ovarian cancer || adult astrocytic tumour || cell type benign neoplasm || liver carcinoma || carcinoma || kidney cancer || integumentary system cancer || head and neck squamous cell carcinoma || pancreatic ductal adenocarcinoma || bile duct adenocarcinoma || breast cancer || ovary epithelial cancer || salivary gland adenoid cystic carcinoma || renal cell carcinoma |
| Leucine zipper domain | 0.00621 | INHERITED FROM: hematologic cancer |
| Ubiquitin-like | 0.00694 | INHERITED FROM: pilocytic astrocytoma |
| TIMP-like | 0.008392 | INHERITED FROM: myeloid neoplasm || renal carcinoma || bone marrow cancer |
| SAM/Pointed domain | 0.01113 | INHERITED FROM: invasive ductal carcinoma |
| Growth factor receptor domain | 0.01273 | INHERITED FROM: peripheral nerve sheath neoplasm || malignant glioma || neurofibroma || large intestine cancer || skin hemangioma || liver carcinoma || kidney cancer || urinary system cancer || colorectal cancer |
| HMG-box | 0.01303 | INHERITED FROM: seminoma || embryonal cancer |
| HLH, helix-loop-helix DNA-binding domain | 0.01308 | INHERITED FROM: autonomic nervous system neoplasm |
| Caspase-like | 0.01541 | INHERITED FROM: melanoma |
| Arginase/deacetylase | 0.01541 | INHERITED FROM: Hodgkin's lymphoma |
| Cyclin-like | 0.01674 | INHERITED FROM: pharynx cancer || retinal cancer || retinal cell cancer || laryngeal carcinoma || sensory system cancer |
| 4-helical cytokines | 0.02773 | INHERITED FROM: Sezary's disease || organ system cancer || myeloid neoplasm || placenta cancer || non-small cell lung carcinoma || immune system cancer || hematologic cancer |
| Bcl-2 inhibitors of programmed cell death | 0.02859 | INHERITED FROM: stomach carcinoma || organ system cancer || connective tissue cancer || chronic lymphocytic leukemia || carcinoma || gastric adenocarcinoma || leukemia || osteosarcoma |
| Frizzled cysteine-rich domain | 0.03501 | INHERITED FROM: myeloid leukemia || multiple myeloma || myeloid neoplasm |
| TNF receptor-like | 0.03504 | INHERITED FROM: myeloid neoplasm || breast carcinoma || immune system cancer || pancreatic adenocarcinoma || breast cancer || hematologic cancer |
| FnI-like domain | 0.04455 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| Snake toxin-like | 0.04455 | INHERITED FROM: retinal cancer || retinal cell cancer |
| Hemopexin-like domain | 0.04455 | INHERITED FROM: meningioma || endometrial cancer || astrocytoma || reproductive organ cancer || myeloid neoplasm || prostate cancer || chondrosarcoma || endometrial carcinoma || ovarian cancer || adult astrocytic tumour || carcinoma || integumentary system cancer || head and neck squamous cell carcinoma || ovary epithelial cancer || salivary gland adenoid cystic carcinoma || bone marrow cancer |
| Thyroglobulin type-1 domain | 0.04562 | INHERITED FROM: renal carcinoma || retinal cancer || kidney cancer || retinal cell cancer || renal cell carcinoma |
| SOCS box-like | 0.0526 | INHERITED FROM: in situ carcinoma || pre-malignant neoplasm || chronic myeloid leukemia |
| Metalloproteases ("zincins"), catalytic domain | 0.05316 | INHERITED FROM: oral cavity cancer || endometrial cancer || reproductive organ cancer || prostate cancer || chondrosarcoma || endometrial carcinoma || cell type cancer || adult astrocytic tumour || integumentary system cancer || breast cancer || salivary gland adenoid cystic carcinoma |
| BRCT domain | 0.05639 | INHERITED FROM: sporadic breast cancer |
| Ran binding protein zinc finger-like | 0.0769 | INHERITED FROM: sarcoma || retinal cancer || retinal cell cancer || sensory system cancer |
| Blood coagulation inhibitor (disintegrin) | 0.09919 | INHERITED FROM: breast carcinoma || skin carcinoma || basal cell carcinoma |
| Galactose-binding domain-like | 0.1292 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Lipoxigenase | 0.1775 | INHERITED FROM: adenoma || cell type benign neoplasm || benign neoplasm |
| Immunoglobulin | 0.1954 | INHERITED FROM: immune system cancer || fibrosarcoma of bone || endometrial stromal sarcoma |
| Kringle-like | 0.2028 | INHERITED FROM: meningioma || Hodgkin's lymphoma || lung carcinoma || connective tissue cancer || bone cancer || pancreatic ductal adenocarcinoma || pancreatic adenocarcinoma || thymoma || invasive ductal carcinoma || thymus cancer || laryngeal carcinoma |
| Notch domain | 0.2379 | INHERITED FROM: liver cancer || integumentary system benign neoplasm || organ system benign neoplasm || renal carcinoma || skin hemangioma || cell type benign neoplasm || liver carcinoma || kidney cancer || urinary system cancer || benign neoplasm || hemangioma || lymphoblastic leukemia || renal cell carcinoma |
| Putative DNA-binding domain | 0.2379 | INHERITED FROM: cell type benign neoplasm |
| Toll/Interleukin receptor TIR domain | 0.2384 | INHERITED FROM: mature T-cell and NK-cell lymphoma || mycosis fungoides |
| A DNA-binding domain in eukaryotic transcription factors | 0.2585 | INHERITED FROM: immune system cancer || hematologic cancer |
| Thioredoxin-like | 0.2744 | INHERITED FROM: adenoma || oligodendroglioma |
| p53-like transcription factors | 0.2893 | INHERITED FROM: musculoskeletal system cancer || connective tissue cancer || cervix carcinoma || mammary Paget's disease || head and neck cancer || breast adenocarcinoma || colon cancer || B-cell lymphoma || hemangioma || Burkitt lymphoma || laryngeal carcinoma || salivary gland adenoid cystic carcinoma || head and neck carcinoma || chronic leukemia || hematologic cancer || renal cell carcinoma |
| Nucleotide-diphospho-sugar transferases | 0.2893 | INHERITED FROM: prostate adenocarcinoma |
| Defensin-like | 0.3212 | INHERITED FROM: mature T-cell and NK-cell lymphoma || mycosis fungoides || non-Hodgkin lymphoma |
| Heme-dependent peroxidases | 0.3212 | INHERITED FROM: cell type benign neoplasm || benign neoplasm |
| Globin-like | 0.3725 | INHERITED FROM: in situ carcinoma || pre-malignant neoplasm |
| Prefoldin | 0.3763 | INHERITED FROM: lung large cell carcinoma || pulmonary large cell neuroendocrine carcinoma || neuroendocrine carcinoma |
| Ankyrin repeat | 0.3849 | INHERITED FROM: skeletal muscle cancer || skin hemangioma || rhabdomyosarcoma |
| Second domain of FERM | 0.3891 | INHERITED FROM: meningioma |
| STAT | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
| Transcription factor STAT-4 N-domain | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
| TSP-1 type 1 repeat | 0.4296 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| MHC antigen-recognition domain | 0.4475 | INHERITED FROM: liver carcinoma || chronic myeloid leukemia || leukemia |
| Interleukin 8-like chemokines | 0.4902 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| Trypsin-like serine proteases | 0.53 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| ABC transporter transmembrane region | 0.5829 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| DNA repair protein MutS, domain III | 0.5943 | INHERITED FROM: urinary system cancer |
| Nucleoside diphosphate kinase, NDK | 0.5943 | INHERITED FROM: myeloid leukemia |
| TNF-like | 0.639 | INHERITED FROM: myeloid neoplasm || B-cell lymphoma || Burkitt lymphoma |
| Family A G protein-coupled receptor-like | 0.6699 | INHERITED FROM: ACTH-secreting pituitary adenoma || Conn's syndrome |
| Cytokine | 0.6848 | INHERITED FROM: Hodgkin's lymphoma |
| EF-hand | 0.7331 | INHERITED FROM: keratoacanthoma |
| DPP6 N-terminal domain-like | 0.7651 | INHERITED FROM: meningioma || chronic lymphocytic leukemia || central nervous system cancer |
| alpha/beta-Hydrolases | 0.812 | INHERITED FROM: meningioma || central nervous system cancer |
| Intermediate filament protein, coiled coil region | 0.9184 | INHERITED FROM: lung large cell carcinoma || pulmonary large cell neuroendocrine carcinoma || neuroendocrine carcinoma |
| HD-domain/PDEase-like | 0.9611 | INHERITED FROM: chronic lymphocytic leukemia || lymphoblastic leukemia |
| SNARE fusion complex | 0.9988 | INHERITED FROM: parathyroid adenoma || endocrine organ benign neoplasm |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Triple coiled coil domain of C-type lectins | 0 | Direct |
| Saposin | 0 | Direct |
| Proteasome activator | 0 | Direct |
| DNA clamp | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| ACP-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| HIT-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Acid proteases | 0 | Direct |
| CCHHC domain | 0 | Direct |
| GroES-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| BTG domain-like | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| SRF-like | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| PAZ domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Orange domain-like | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Metallothionein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Sialidases | 0 | Direct |
| Uteroglobin-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| Annexin | 0 | Direct |
| Synuclein | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| BAG domain | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Flavoproteins | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0.00001428 | Direct |
| Protein kinase-like (PK-like) | 0.00003208 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0003726 | Direct |
| SH2 domain | 0.0007314 | Direct |
| Integrin domains | 0.001723 | Inherited |
| Cystine-knot cytokines | 0.006017 | Inherited |
| PGBD-like | 0.006077 | Inherited |
| Leucine zipper domain | 0.00621 | Inherited |
| Ubiquitin-like | 0.00694 | Inherited |
| TIMP-like | 0.008392 | Inherited |
| SAM/Pointed domain | 0.01113 | Inherited |
| Growth factor receptor domain | 0.01273 | Inherited |
| HMG-box | 0.01303 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01308 | Inherited |
| Caspase-like | 0.01541 | Inherited |
| Arginase/deacetylase | 0.01541 | Inherited |
| Cyclin-like | 0.01674 | Inherited |
| 4-helical cytokines | 0.02773 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.02859 | Inherited |
| Frizzled cysteine-rich domain | 0.03501 | Inherited |
| TNF receptor-like | 0.03504 | Inherited |
| FnI-like domain | 0.04455 | Inherited |
| Snake toxin-like | 0.04455 | Inherited |
| Hemopexin-like domain | 0.04455 | Inherited |
| Thyroglobulin type-1 domain | 0.04562 | Inherited |
| SOCS box-like | 0.0526 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.05316 | Inherited |
| BRCT domain | 0.05639 | Inherited |
| Ran binding protein zinc finger-like | 0.0769 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.09919 | Inherited |
| Galactose-binding domain-like | 0.1292 | Inherited |
| Lipoxigenase | 0.1775 | Inherited |
| Immunoglobulin | 0.1954 | Inherited |
| Kringle-like | 0.2028 | Inherited |
| Notch domain | 0.2379 | Inherited |
| Putative DNA-binding domain | 0.2379 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2384 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.2585 | Inherited |
| Thioredoxin-like | 0.2744 | Inherited |
| p53-like transcription factors | 0.2893 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.2893 | Inherited |
| Defensin-like | 0.3212 | Inherited |
| Heme-dependent peroxidases | 0.3212 | Inherited |
| Globin-like | 0.3725 | Inherited |
| Prefoldin | 0.3763 | Inherited |
| Ankyrin repeat | 0.3849 | Inherited |
| Second domain of FERM | 0.3891 | Inherited |
| STAT | 0.3988 | Inherited |
| Transcription factor STAT-4 N-domain | 0.3988 | Inherited |
| TSP-1 type 1 repeat | 0.4296 | Inherited |
| MHC antigen-recognition domain | 0.4475 | Inherited |
| Interleukin 8-like chemokines | 0.4902 | Inherited |
| Trypsin-like serine proteases | 0.53 | Inherited |
| ABC transporter transmembrane region | 0.5829 | Inherited |
| DNA repair protein MutS, domain III | 0.5943 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.5943 | Inherited |
| TNF-like | 0.639 | Inherited |
| Family A G protein-coupled receptor-like | 0.6699 | Inherited |
| Cytokine | 0.6848 | Inherited |
| EF-hand | 0.7331 | Inherited |
| DPP6 N-terminal domain-like | 0.7651 | Inherited |
| alpha/beta-Hydrolases | 0.812 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9184 | Inherited |
| HD-domain/PDEase-like | 0.9611 | Inherited |
| SNARE fusion complex | 0.9988 | Inherited |
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,50370
53448 - Nucleotide-diphospho-sugar transferases
50370 - Ricin B-like lectins | 0 | DIRECT |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
55550,50729
55550 - SH2 domain
50729 - PH domain-like | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | DIRECT |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | DIRECT |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | DIRECT |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
50044,56112
50044 - SH3-domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
50729,57863
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0 | DIRECT |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.001639 | INHERITED FROM: endometrial cancer || endometrial carcinoma || cell type benign neoplasm || thyroid carcinoma || thyroid cancer |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.006077 | INHERITED FROM: oral cavity cancer || endometrial cancer || astrocytoma || connective tissue cancer || reproductive organ cancer || myeloid neoplasm || prostate cancer || chondrosarcoma || renal carcinoma || endometrial carcinoma || cell type cancer || ovarian cancer || adult astrocytic tumour || cell type benign neoplasm || liver carcinoma || carcinoma || kidney cancer || integumentary system cancer || head and neck squamous cell carcinoma || pancreatic ductal adenocarcinoma || bile duct adenocarcinoma || breast cancer || ovary epithelial cancer || salivary gland adenoid cystic carcinoma || renal cell carcinoma |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.008392 | INHERITED FROM: reproductive organ cancer || prostate cancer || prostate carcinoma || chondrosarcoma || carcinoma |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02681 | INHERITED FROM: myeloid neoplasm || breast carcinoma || liver carcinoma || immune system cancer || pancreatic adenocarcinoma || breast cancer || hematologic cancer |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.04562 | INHERITED FROM: nasopharynx carcinoma || retinal cancer || retinal cell cancer || laryngeal carcinoma || sensory system cancer || hematologic cancer |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.0719 | INHERITED FROM: breast ductal carcinoma || pancreatic cancer || pancreatic ductal adenocarcinoma || pancreatic adenocarcinoma || invasive ductal carcinoma |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.0719 | INHERITED FROM: melanoma |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.09721 | INHERITED FROM: pancreatic cancer || breast carcinoma || leukemia || pancreatic adenocarcinoma || invasive ductal carcinoma || hematologic cancer |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.09919 | INHERITED FROM: breast carcinoma || skin carcinoma || basal cell carcinoma |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1016 | INHERITED FROM: immune system cancer |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1297 | INHERITED FROM: skin hemangioma |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.1312 | INHERITED FROM: in situ carcinoma || pre-malignant neoplasm || chronic myeloid leukemia |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.1775 | INHERITED FROM: renal carcinoma || kidney cancer || bone marrow cancer || lymphoblastic leukemia || renal cell carcinoma |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.1775 | INHERITED FROM: myeloid neoplasm || bone marrow cancer |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.1775 | INHERITED FROM: adenoma || cell type benign neoplasm || benign neoplasm |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.2056 | INHERITED FROM: nasopharynx carcinoma || colon cancer || hemangioma |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.2585 | INHERITED FROM: immune system cancer || hematologic cancer |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.2805 | INHERITED FROM: meningioma |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0.3182 | INHERITED FROM: breast carcinoma || cell type benign neoplasm || thoracic cancer || benign neoplasm || breast cancer |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.3212 | INHERITED FROM: lung large cell carcinoma || pulmonary large cell neuroendocrine carcinoma || neuroendocrine carcinoma |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3643 | INHERITED FROM: immune system cancer || fibrosarcoma of bone || endometrial stromal sarcoma |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.4177 | INHERITED FROM: meningioma |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.4334 | INHERITED FROM: nasopharynx carcinoma || leukemia |
81296,81296
81296 - E set domains
81296 - E set domains | 0.4422 | INHERITED FROM: prostate cancer || male reproductive organ cancer |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0.4909 | INHERITED FROM: meningioma || chronic lymphocytic leukemia || nervous system cancer || lymphoblastic leukemia || central nervous system cancer |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.5759 | INHERITED FROM: integumentary system benign neoplasm || organ system benign neoplasm || renal carcinoma || skin hemangioma || kidney cancer || hemangioma || renal cell carcinoma |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5829 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5943 | INHERITED FROM: urinary system cancer |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,50370
53448 - Nucleotide-diphospho-sugar transferases
50370 - Ricin B-like lectins | 0 | Direct |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
55550,50729
55550 - SH2 domain
50729 - PH domain-like | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | Direct |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | Direct |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | Direct |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
50044,56112
50044 - SH3-domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
50729,57863
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0 | Direct |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.001639 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.006077 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.008392 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02681 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.04562 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.0719 | Inherited |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.0719 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.09721 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.09919 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1016 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1297 | Inherited |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.1312 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.1775 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.1775 | Inherited |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.1775 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.2056 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.2585 | Inherited |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.2805 | Inherited |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0.3182 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.3212 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3643 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.3988 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3988 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.3988 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.4177 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.4334 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.4422 | Inherited |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0.4909 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.5759 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5829 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5943 | Inherited |
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01541 | INHERITED FROM: reproductive organ cancer || prostate cancer || prostate carcinoma || chondrosarcoma || carcinoma || ovary epithelial cancer |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0719 | INHERITED FROM: organ system benign neoplasm || renal carcinoma || skin hemangioma || kidney cancer || hemangioma || renal cell carcinoma |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.08338 | INHERITED FROM: renal carcinoma || skin hemangioma |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.2805 | INHERITED FROM: meningioma |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0.3182 | INHERITED FROM: breast carcinoma || cell type benign neoplasm || thoracic cancer || benign neoplasm || breast cancer |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.3461 | INHERITED FROM: organ system benign neoplasm || skin hemangioma || hemangioma |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3988 | INHERITED FROM: head and neck cancer || chronic myeloid leukemia || head and neck carcinoma || chronic leukemia |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.5218 | INHERITED FROM: breast carcinoma |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.6248 | INHERITED FROM: fibrosarcoma of bone |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | Direct |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01541 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0719 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.08338 | Inherited |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.2805 | Inherited |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0.3182 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.3461 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.3988 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3988 | Inherited |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.5218 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.6248 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
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