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Disease Ontology (DO): cancer
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: DO Hierarchy (disease ontology from University of Maryland)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this DO term (Not in SDDO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Triple coiled coil domain of C-type lectins | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Uteroglobin-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00001505 | DIRECT |
| Integrin domains | 0.002054 | INHERITED FROM: multiple myeloma || breast cancer |
| PGBD-like | 0.007263 | INHERITED FROM: ovarian cancer || adult astrocytic tumour || kidney cancer || salivary gland adenoid cystic carcinoma || bile duct adenocarcinoma || liver carcinoma || astrocytoma || endometrial cancer || carcinoma || prostate cancer || ovary epithelial cancer || reproductive organ cancer || myeloid neoplasm || chondrosarcoma || endometrial carcinoma || pancreatic ductal adenocarcinoma || cell type cancer || head and neck squamous cell carcinoma || breast cancer || renal carcinoma || integumentary system cancer || renal cell carcinoma || oral cavity cancer |
| TIMP-like | 0.009894 | INHERITED FROM: myeloid neoplasm || renal carcinoma || bone marrow cancer |
| Growth factor receptor domain | 0.01126 | INHERITED FROM: large intestine cancer || kidney cancer || liver carcinoma || urinary system cancer || peripheral nerve sheath neoplasm || malignant glioma || neurofibroma || colorectal cancer |
| HLH, helix-loop-helix DNA-binding domain | 0.01248 | INHERITED FROM: autonomic nervous system neoplasm |
| HMG-box | 0.01467 | INHERITED FROM: embryonal cancer || seminoma |
| Arginase/deacetylase | 0.01813 | INHERITED FROM: Hodgkin's lymphoma |
| Caspase-like | 0.01813 | INHERITED FROM: melanoma |
| 4-helical cytokines | 0.02814 | INHERITED FROM: immune system cancer || Sezary's disease || placenta cancer || myeloid neoplasm || organ system cancer || hematologic cancer |
| Bcl-2 inhibitors of programmed cell death | 0.03325 | INHERITED FROM: chronic lymphocytic leukemia || connective tissue cancer || carcinoma || stomach carcinoma || organ system cancer || osteosarcoma || gastric adenocarcinoma |
| TNF receptor-like | 0.03867 | INHERITED FROM: pancreatic adenocarcinoma || immune system cancer || myeloid neoplasm || hematologic cancer || breast carcinoma || breast cancer |
| Hemopexin-like domain | 0.04885 | INHERITED FROM: ovarian cancer || adult astrocytic tumour || salivary gland adenoid cystic carcinoma || endometrial cancer || carcinoma || prostate cancer || ovary epithelial cancer || reproductive organ cancer || myeloid neoplasm || chondrosarcoma || endometrial carcinoma || meningioma || integumentary system cancer || bone marrow cancer |
| Snake toxin-like | 0.04885 | INHERITED FROM: retinal cancer || retinal cell cancer |
| Metalloproteases ("zincins"), catalytic domain | 0.05053 | INHERITED FROM: adult astrocytic tumour || salivary gland adenoid cystic carcinoma || endometrial cancer || prostate cancer || reproductive organ cancer || chondrosarcoma || endometrial carcinoma || cell type cancer || breast cancer || integumentary system cancer || oral cavity cancer |
| Thyroglobulin type-1 domain | 0.05104 | INHERITED FROM: kidney cancer || renal carcinoma || renal cell carcinoma |
| SOCS box-like | 0.06079 | INHERITED FROM: chronic myeloid leukemia |
| Ran binding protein zinc finger-like | 0.08566 | INHERITED FROM: sarcoma || retinal cancer || sensory system cancer || retinal cell cancer |
| Blood coagulation inhibitor (disintegrin) | 0.1101 | INHERITED FROM: basal cell carcinoma || skin carcinoma |
| Galactose-binding domain-like | 0.1315 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Protein kinase-like (PK-like) | 0.2049 | INHERITED FROM: large intestine cancer || lung carcinoma || bile duct adenocarcinoma || liver carcinoma || cervical adenocarcinoma || rhabdomyosarcoma || malignant glioma || organ system cancer || breast cancer || retinal cell cancer || thoracic cancer |
| Kringle-like | 0.2154 | INHERITED FROM: connective tissue cancer || lung carcinoma || Hodgkin's lymphoma || meningioma || bone cancer || pancreatic ductal adenocarcinoma || thymus cancer || laryngeal carcinoma || thymoma || invasive ductal carcinoma |
| Toll/Interleukin receptor TIR domain | 0.2532 | INHERITED FROM: mycosis fungoides || mature T-cell and NK-cell lymphoma |
| Notch domain | 0.2672 | INHERITED FROM: liver cancer || kidney cancer || liver carcinoma || lymphoblastic leukemia || urinary system cancer || renal carcinoma || renal cell carcinoma |
| Thioredoxin-like | 0.2677 | INHERITED FROM: oligodendroglioma |
| A DNA-binding domain in eukaryotic transcription factors | 0.2836 | INHERITED FROM: immune system cancer || hematologic cancer |
| p53-like transcription factors | 0.2964 | INHERITED FROM: head and neck cancer || connective tissue cancer || salivary gland adenoid cystic carcinoma || mammary Paget's disease || head and neck carcinoma || colon cancer || chronic leukemia || B-cell lymphoma || laryngeal carcinoma || breast adenocarcinoma || Burkitt lymphoma |
| Nucleotide-diphospho-sugar transferases | 0.2964 | INHERITED FROM: prostate adenocarcinoma |
| Defensin-like | 0.3536 | INHERITED FROM: mycosis fungoides || mature T-cell and NK-cell lymphoma || non-Hodgkin lymphoma |
| Prefoldin | 0.3975 | INHERITED FROM: neuroendocrine carcinoma || pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma |
| Transcription factor STAT-4 N-domain | 0.4365 | INHERITED FROM: head and neck cancer || head and neck carcinoma || chronic leukemia || chronic myeloid leukemia |
| STAT | 0.4365 | INHERITED FROM: head and neck cancer || head and neck carcinoma || chronic leukemia || chronic myeloid leukemia |
| TSP-1 type 1 repeat | 0.442 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| MHC antigen-recognition domain | 0.4642 | INHERITED FROM: leukemia || chronic myeloid leukemia |
| Interleukin 8-like chemokines | 0.4991 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| Immunoglobulin | 0.6044 | INHERITED FROM: fibrosarcoma of bone || immune system cancer || endometrial stromal sarcoma |
| ABC transporter transmembrane region | 0.6116 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| DNA repair protein MutS, domain III | 0.6464 | INHERITED FROM: urinary system cancer |
| TNF-like | 0.6688 | INHERITED FROM: myeloid neoplasm || B-cell lymphoma || Burkitt lymphoma |
| Cystine-knot cytokines | 0.6944 | INHERITED FROM: skeletal muscle cancer || rhabdomyosarcoma || prostate cancer || reproductive organ cancer || myelofibrosis |
| SAM/Pointed domain | 0.7153 | INHERITED FROM: invasive ductal carcinoma |
| Leucine zipper domain | 0.7747 | INHERITED FROM: hematologic cancer |
| DPP6 N-terminal domain-like | 0.8176 | INHERITED FROM: chronic lymphocytic leukemia || central nervous system cancer || meningioma |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.838 | INHERITED FROM: endometrial cancer || endometrial carcinoma |
| alpha/beta-Hydrolases | 0.8412 | INHERITED FROM: central nervous system cancer || meningioma |
| Ubiquitin-like | 0.8504 | INHERITED FROM: pilocytic astrocytoma |
| Cyclin-like | 0.8739 | INHERITED FROM: retinal cancer || sensory system cancer || retinal cell cancer || laryngeal carcinoma |
| SH2 domain | 0.8823 | INHERITED FROM: organ system cancer || myelodysplastic/myeloproliferative neoplasm || chronic myeloid leukemia || breast cancer |
| Second domain of FERM | 0.8926 | INHERITED FROM: meningioma |
| FnI-like domain | 0.9092 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| Ankyrin repeat | 0.9314 | INHERITED FROM: skeletal muscle cancer || rhabdomyosarcoma |
| Frizzled cysteine-rich domain | 0.935 | INHERITED FROM: multiple myeloma || myeloid neoplasm |
| Intermediate filament protein, coiled coil region | 0.963 | INHERITED FROM: neuroendocrine carcinoma || pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma |
| HD-domain/PDEase-like | 1 | INHERITED FROM: chronic lymphocytic leukemia |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Metallothionein | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| BAG domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Sialidases | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Polo-box domain | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Flavoproteins | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| HIT-like | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Insulin-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| GroES-like | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Proteasome activator | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Triple coiled coil domain of C-type lectins | 0 | Direct |
| DNA clamp | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| PAZ domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Uteroglobin-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| PP2C-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| ACP-like | 0 | Direct |
| BTG domain-like | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0.00001505 | Direct |
| Integrin domains | 0.002054 | Inherited |
| PGBD-like | 0.007263 | Inherited |
| TIMP-like | 0.009894 | Inherited |
| Growth factor receptor domain | 0.01126 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01248 | Inherited |
| HMG-box | 0.01467 | Inherited |
| Arginase/deacetylase | 0.01813 | Inherited |
| Caspase-like | 0.01813 | Inherited |
| 4-helical cytokines | 0.02814 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.03325 | Inherited |
| TNF receptor-like | 0.03867 | Inherited |
| Hemopexin-like domain | 0.04885 | Inherited |
| Snake toxin-like | 0.04885 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.05053 | Inherited |
| Thyroglobulin type-1 domain | 0.05104 | Inherited |
| SOCS box-like | 0.06079 | Inherited |
| Ran binding protein zinc finger-like | 0.08566 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.1101 | Inherited |
| Galactose-binding domain-like | 0.1315 | Inherited |
| Protein kinase-like (PK-like) | 0.2049 | Inherited |
| Kringle-like | 0.2154 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2532 | Inherited |
| Notch domain | 0.2672 | Inherited |
| Thioredoxin-like | 0.2677 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.2836 | Inherited |
| p53-like transcription factors | 0.2964 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.2964 | Inherited |
| Defensin-like | 0.3536 | Inherited |
| Prefoldin | 0.3975 | Inherited |
| Transcription factor STAT-4 N-domain | 0.4365 | Inherited |
| STAT | 0.4365 | Inherited |
| TSP-1 type 1 repeat | 0.442 | Inherited |
| MHC antigen-recognition domain | 0.4642 | Inherited |
| Interleukin 8-like chemokines | 0.4991 | Inherited |
| Immunoglobulin | 0.6044 | Inherited |
| ABC transporter transmembrane region | 0.6116 | Inherited |
| DNA repair protein MutS, domain III | 0.6464 | Inherited |
| TNF-like | 0.6688 | Inherited |
| Cystine-knot cytokines | 0.6944 | Inherited |
| SAM/Pointed domain | 0.7153 | Inherited |
| Leucine zipper domain | 0.7747 | Inherited |
| DPP6 N-terminal domain-like | 0.8176 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.838 | Inherited |
| alpha/beta-Hydrolases | 0.8412 | Inherited |
| Ubiquitin-like | 0.8504 | Inherited |
| Cyclin-like | 0.8739 | Inherited |
| SH2 domain | 0.8823 | Inherited |
| Second domain of FERM | 0.8926 | Inherited |
| FnI-like domain | 0.9092 | Inherited |
| Ankyrin repeat | 0.9314 | Inherited |
| Frizzled cysteine-rich domain | 0.935 | Inherited |
| Intermediate filament protein, coiled coil region | 0.963 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this DO term (Not in SDDO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| UDPGT-like | 0 | DIRECT |
| Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Ricin B-like | 0 | DIRECT |
| Prokaryotic proteases | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| STAR domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| DIX domain | 0 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Bee venom hyaluronidase | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Sialidases (neuraminidases) | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| AlkB-like | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| C2 set domains | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Triple coiled coil domain of C-type lectins | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| Arginase-like amidino hydrolases | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| Uteroglobin-like | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| CAD domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| GABARAP-like | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Aldo-keto reductases (NADP) | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Methyl-CpG-binding domain, MBD | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| Integrin beta EGF-like domains | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Cystatins | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| HtrA-like serine proteases | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00001196 | DIRECT |
| Nuclear receptor | 0.00002363 | DIRECT |
| Growth factor receptor domain | 0.0007262 | DIRECT |
| Integrin domains | 0.001552 | INHERITED FROM: multiple myeloma || breast cancer |
| Matrix metalloproteases, catalytic domain | 0.002141 | INHERITED FROM: ovarian cancer || adult astrocytic tumour || kidney cancer || salivary gland adenoid cystic carcinoma || bile duct adenocarcinoma || astrocytoma || endometrial cancer || carcinoma || prostate cancer || ovary epithelial cancer || reproductive organ cancer || myeloid neoplasm || chondrosarcoma || endometrial carcinoma || cell type cancer || head and neck squamous cell carcinoma || renal carcinoma || integumentary system cancer || renal cell carcinoma || oral cavity cancer |
| MMP N-terminal domain | 0.00559 | INHERITED FROM: ovarian cancer || adult astrocytic tumour || kidney cancer || salivary gland adenoid cystic carcinoma || bile duct adenocarcinoma || liver carcinoma || astrocytoma || endometrial cancer || carcinoma || prostate cancer || ovary epithelial cancer || reproductive organ cancer || myeloid neoplasm || chondrosarcoma || endometrial carcinoma || pancreatic ductal adenocarcinoma || cell type cancer || head and neck squamous cell carcinoma || breast cancer || renal carcinoma || integumentary system cancer || renal cell carcinoma || oral cavity cancer |
| HLH, helix-loop-helix DNA-binding domain | 0.01106 | INHERITED FROM: autonomic nervous system neoplasm |
| HMG-box | 0.01193 | INHERITED FROM: embryonal cancer || seminoma |
| Caspase catalytic domain | 0.02677 | INHERITED FROM: melanoma |
| Bcl-2 inhibitors of programmed cell death | 0.02677 | INHERITED FROM: chronic lymphocytic leukemia || connective tissue cancer || carcinoma || leukemia || stomach carcinoma || organ system cancer || osteosarcoma || gastric adenocarcinoma |
| S100 proteins | 0.02677 | INHERITED FROM: lung carcinoma || respiratory system cancer || organ system cancer || non-small cell lung carcinoma || cell type cancer || breast cancer |
| Histone deacetylase, HDAC | 0.03684 | INHERITED FROM: lymphoma || Hodgkin's lymphoma |
| Long-chain cytokines | 0.03684 | INHERITED FROM: female reproductive organ cancer || breast cancer || thoracic cancer |
| Hemopexin-like domain | 0.0412 | INHERITED FROM: ovarian cancer || adult astrocytic tumour || salivary gland adenoid cystic carcinoma || endometrial cancer || carcinoma || prostate cancer || ovary epithelial cancer || reproductive organ cancer || myeloid neoplasm || chondrosarcoma || endometrial carcinoma || meningioma || integumentary system cancer || bone marrow cancer |
| Thyroglobulin type-1 domain | 0.04276 | INHERITED FROM: kidney cancer || retinal cancer || retinal cell cancer || renal carcinoma || renal cell carcinoma |
| SAM (sterile alpha motif) domain | 0.05037 | INHERITED FROM: endocrine gland cancer || invasive ductal carcinoma |
| SOCS box-like | 0.05037 | INHERITED FROM: chronic myeloid leukemia |
| TNF receptor-like | 0.06678 | INHERITED FROM: pancreatic adenocarcinoma || pancreatic cancer || immune system cancer || myeloid neoplasm || hematologic cancer || breast carcinoma || breast cancer |
| Paired domain | 0.06876 | INHERITED FROM: skeletal muscle cancer || rhabdomyosarcoma || alveolar rhabdomyosarcoma |
| Ran binding protein zinc finger-like | 0.073 | INHERITED FROM: sarcoma || retinal cancer || sensory system cancer || retinal cell cancer |
| Blood coagulation inhibitor (disintegrin) | 0.09461 | INHERITED FROM: breast carcinoma || basal cell carcinoma || skin carcinoma |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.09461 | INHERITED FROM: bile duct cancer || bile duct adenocarcinoma || astrocytoma || leukemia || hematologic cancer |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.122 | INHERITED FROM: colon cancer |
| Ephrin ectodomain | 0.1276 | INHERITED FROM: bone cancer || osteosarcoma |
| PB1 domain | 0.1276 | INHERITED FROM: breast cancer |
| ABC transporter transmembrane region | 0.1356 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| First domain of FERM | 0.1661 | INHERITED FROM: meningioma |
| EGF-type module | 0.1773 | INHERITED FROM: histiocytoma |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.2011 | INHERITED FROM: colon cancer || nasopharynx carcinoma |
| Fibronectin type II module | 0.2011 | INHERITED FROM: connective tissue cancer || thyroid cancer || Hodgkin's lymphoma || myeloid neoplasm || bone cancer || osteosarcoma || head and neck squamous cell carcinoma || thyroid carcinoma || thymus cancer || laryngeal carcinoma || thymoma |
| Protein kinases, catalytic subunit | 0.2083 | INHERITED FROM: large intestine cancer || lung carcinoma || liver carcinoma || cervical adenocarcinoma || rhabdomyosarcoma || prostate cancer || malignant glioma || organ system cancer || breast cancer || retinal cell cancer || thoracic cancer |
| Notch domain | 0.2371 | INHERITED FROM: liver cancer || kidney cancer || liver carcinoma || lymphoblastic leukemia || urinary system cancer || renal carcinoma || renal cell carcinoma |
| A DNA-binding domain in eukaryotic transcription factors | 0.2552 | INHERITED FROM: immune system cancer || hematologic cancer |
| Toll/Interleukin receptor TIR domain | 0.2734 | INHERITED FROM: mycosis fungoides || mature T-cell and NK-cell lymphoma |
| C1 set domains (antibody constant domain-like) | 0.2995 | INHERITED FROM: chronic leukemia || leukemia |
| Hexokinase | 0.3223 | INHERITED FROM: adenocarcinoma |
| Nucleoside diphosphate kinase, NDK | 0.3223 | INHERITED FROM: myeloid leukemia |
| Defensin | 0.3225 | INHERITED FROM: mycosis fungoides || mature T-cell and NK-cell lymphoma || non-Hodgkin lymphoma |
| Third domain of FERM | 0.3964 | INHERITED FROM: meningioma |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.3984 | INHERITED FROM: papillary carcinoma |
| STAT | 0.4036 | INHERITED FROM: head and neck cancer || head and neck carcinoma || chronic leukemia || chronic myeloid leukemia |
| Transcription factor STAT-4 N-domain | 0.4036 | INHERITED FROM: head and neck cancer || head and neck carcinoma || chronic leukemia || chronic myeloid leukemia |
| STAT DNA-binding domain | 0.4036 | INHERITED FROM: head and neck cancer || head and neck carcinoma || chronic leukemia || chronic myeloid leukemia |
| Kringle modules | 0.4064 | INHERITED FROM: pancreatic ductal adenocarcinoma || invasive ductal carcinoma |
| TSP-1 type 1 repeat | 0.4237 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| I set domains | 0.4343 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| MHC antigen-recognition domain | 0.4438 | INHERITED FROM: leukemia || chronic myeloid leukemia |
| Eukaryotic proteases | 0.4738 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Interleukin 8-like chemokines | 0.482 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| DPP6 N-terminal domain-like | 0.4993 | INHERITED FROM: chronic lymphocytic leukemia || nervous system cancer || central nervous system cancer || meningioma |
| Reprolysin-like | 0.5307 | INHERITED FROM: breast carcinoma |
| DPP6 catalytic domain-like | 0.6099 | INHERITED FROM: central nervous system cancer || meningioma |
| DNA repair protein MutS, domain III | 0.6099 | INHERITED FROM: urinary system cancer |
| TNF-like | 0.6466 | INHERITED FROM: myeloid neoplasm || B-cell lymphoma || Burkitt lymphoma |
| Leucine zipper domain | 0.737 | INHERITED FROM: hematologic cancer |
| Transforming growth factor (TGF)-beta | 0.8064 | INHERITED FROM: prostate cancer || reproductive organ cancer || basal cell carcinoma |
| SH2 domain | 0.8503 | INHERITED FROM: organ system cancer || myelodysplastic/myeloproliferative neoplasm || chronic myeloid leukemia |
| ABC transporter ATPase domain-like | 0.8658 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| Interleukin-1 (IL-1) | 0.8662 | INHERITED FROM: pancreatic cancer || multiple myeloma |
| Second domain of FERM | 0.8695 | INHERITED FROM: meningioma |
| PDEase | 0.8831 | INHERITED FROM: chronic lymphocytic leukemia || lymphoblastic leukemia |
| Cyclin | 0.898 | INHERITED FROM: larynx cancer || retinal cancer || sensory system cancer || retinal cell cancer || laryngeal carcinoma |
| Frizzled cysteine-rich domain | 0.9064 | INHERITED FROM: myeloid leukemia || multiple myeloma || myeloid neoplasm |
| Ankyrin repeat | 0.9125 | INHERITED FROM: skeletal muscle cancer || rhabdomyosarcoma |
| Fatty acid binding protein-like | 0.9371 | INHERITED FROM: renal cell carcinoma |
| FHA domain | 0.9459 | INHERITED FROM: retinal cancer || retinal cell cancer |
| Intermediate filament protein, coiled coil region | 0.9489 | INHERITED FROM: neuroendocrine carcinoma || pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma |
| Pointed domain | 0.9884 | INHERITED FROM: breast cancer |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Aconitase iron-sulfur domain | 0 | Direct |
| BAG domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| SRF-like | 0 | Direct |
| UDPGT-like | 0 | Direct |
| Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain | 0 | Direct |
| Annexin | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Ricin B-like | 0 | Direct |
| Prokaryotic proteases | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| Ephrin receptor ligand binding domain | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| STAR domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| DIX domain | 0 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| BTG domain-like | 0 | Direct |
| DNA ligase | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Bee venom hyaluronidase | 0 | Direct |
| L domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Metallothionein | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Sialidases (neuraminidases) | 0 | Direct |
| PA domain | 0 | Direct |
| Transferrin | 0 | Direct |
| Neurotrophin | 0 | Direct |
| MutT-like | 0 | Direct |
| PAZ domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| AlkB-like | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| ZZ domain | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| C2 set domains | 0 | Direct |
| PP2C-like | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Triple coiled coil domain of C-type lectins | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| Arginase-like amidino hydrolases | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| Uteroglobin-like | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| CAD domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| GABARAP-like | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| Adenain-like | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Aldo-keto reductases (NADP) | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Methyl-CpG-binding domain, MBD | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| Integrin beta EGF-like domains | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Cystatins | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| LeuD-like | 0 | Direct |
| HtrA-like serine proteases | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0.00001196 | Direct |
| Nuclear receptor | 0.00002363 | Direct |
| Growth factor receptor domain | 0.0007262 | Direct |
| Integrin domains | 0.001552 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.002141 | Inherited |
| MMP N-terminal domain | 0.00559 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.01106 | Inherited |
| HMG-box | 0.01193 | Inherited |
| Caspase catalytic domain | 0.02677 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.02677 | Inherited |
| S100 proteins | 0.02677 | Inherited |
| Histone deacetylase, HDAC | 0.03684 | Inherited |
| Long-chain cytokines | 0.03684 | Inherited |
| Hemopexin-like domain | 0.0412 | Inherited |
| Thyroglobulin type-1 domain | 0.04276 | Inherited |
| SAM (sterile alpha motif) domain | 0.05037 | Inherited |
| SOCS box-like | 0.05037 | Inherited |
| TNF receptor-like | 0.06678 | Inherited |
| Paired domain | 0.06876 | Inherited |
| Ran binding protein zinc finger-like | 0.073 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.09461 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.09461 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.122 | Inherited |
| Ephrin ectodomain | 0.1276 | Inherited |
| PB1 domain | 0.1276 | Inherited |
| ABC transporter transmembrane region | 0.1356 | Inherited |
| First domain of FERM | 0.1661 | Inherited |
| EGF-type module | 0.1773 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.2011 | Inherited |
| Fibronectin type II module | 0.2011 | Inherited |
| Protein kinases, catalytic subunit | 0.2083 | Inherited |
| Notch domain | 0.2371 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.2552 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2734 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.2995 | Inherited |
| Hexokinase | 0.3223 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.3223 | Inherited |
| Defensin | 0.3225 | Inherited |
| Third domain of FERM | 0.3964 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.3984 | Inherited |
| STAT | 0.4036 | Inherited |
| Transcription factor STAT-4 N-domain | 0.4036 | Inherited |
| STAT DNA-binding domain | 0.4036 | Inherited |
| Kringle modules | 0.4064 | Inherited |
| TSP-1 type 1 repeat | 0.4237 | Inherited |
| I set domains | 0.4343 | Inherited |
| MHC antigen-recognition domain | 0.4438 | Inherited |
| Eukaryotic proteases | 0.4738 | Inherited |
| Interleukin 8-like chemokines | 0.482 | Inherited |
| DPP6 N-terminal domain-like | 0.4993 | Inherited |
| Reprolysin-like | 0.5307 | Inherited |
| DPP6 catalytic domain-like | 0.6099 | Inherited |
| DNA repair protein MutS, domain III | 0.6099 | Inherited |
| TNF-like | 0.6466 | Inherited |
| Leucine zipper domain | 0.737 | Inherited |
| Transforming growth factor (TGF)-beta | 0.8064 | Inherited |
| SH2 domain | 0.8503 | Inherited |
| ABC transporter ATPase domain-like | 0.8658 | Inherited |
| Interleukin-1 (IL-1) | 0.8662 | Inherited |
| Second domain of FERM | 0.8695 | Inherited |
| PDEase | 0.8831 | Inherited |
| Cyclin | 0.898 | Inherited |
| Frizzled cysteine-rich domain | 0.9064 | Inherited |
| Ankyrin repeat | 0.9125 | Inherited |
| Fatty acid binding protein-like | 0.9371 | Inherited |
| FHA domain | 0.9459 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9489 | Inherited |
| Pointed domain | 0.9884 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Triple coiled coil domain of C-type lectins | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| Uteroglobin-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.000008326 | DIRECT |
| Integrin domains | 0.001337 | INHERITED FROM: multiple myeloma || breast cancer |
| PGBD-like | 0.004991 | INHERITED FROM: endometrial cancer || pancreatic ductal adenocarcinoma || bile duct adenocarcinoma || oral cavity cancer || head and neck squamous cell carcinoma || integumentary system cancer || carcinoma || liver carcinoma || kidney cancer || adult astrocytic tumour || renal cell carcinoma || cell type cancer || endometrial carcinoma || renal carcinoma || ovarian cancer || salivary gland adenoid cystic carcinoma || chondrosarcoma || myeloid neoplasm || prostate cancer || reproductive organ cancer || connective tissue cancer || breast cancer || ovary epithelial cancer || astrocytoma |
| TIMP-like | 0.006887 | INHERITED FROM: bone marrow cancer || renal carcinoma || myeloid neoplasm |
| Growth factor receptor domain | 0.007903 | INHERITED FROM: urinary system cancer || peripheral nerve sheath neoplasm || liver carcinoma || kidney cancer || large intestine cancer || colorectal cancer || neurofibroma || malignant glioma |
| HLH, helix-loop-helix DNA-binding domain | 0.008789 | INHERITED FROM: autonomic nervous system neoplasm |
| HMG-box | 0.01041 | INHERITED FROM: seminoma || embryonal cancer |
| Caspase-like | 0.01303 | INHERITED FROM: melanoma |
| Arginase/deacetylase | 0.01303 | INHERITED FROM: Hodgkin's lymphoma |
| 4-helical cytokines | 0.0208 | INHERITED FROM: organ system cancer || non-small cell lung carcinoma || immune system cancer || Sezary's disease || hematologic cancer || placenta cancer || myeloid neoplasm |
| Bcl-2 inhibitors of programmed cell death | 0.02485 | INHERITED FROM: organ system cancer || osteosarcoma || leukemia || stomach carcinoma || carcinoma || gastric adenocarcinoma || chronic lymphocytic leukemia || connective tissue cancer |
| TNF receptor-like | 0.02899 | INHERITED FROM: pancreatic adenocarcinoma || immune system cancer || hematologic cancer || breast carcinoma || myeloid neoplasm || breast cancer |
| Snake toxin-like | 0.03705 | INHERITED FROM: retinal cell cancer || retinal cancer |
| Hemopexin-like domain | 0.03705 | INHERITED FROM: endometrial cancer || head and neck squamous cell carcinoma || integumentary system cancer || meningioma || carcinoma || adult astrocytic tumour || endometrial carcinoma || bone marrow cancer || ovarian cancer || salivary gland adenoid cystic carcinoma || chondrosarcoma || myeloid neoplasm || prostate cancer || reproductive organ cancer || ovary epithelial cancer || astrocytoma |
| Metalloproteases ("zincins"), catalytic domain | 0.03841 | INHERITED FROM: endometrial cancer || oral cavity cancer || integumentary system cancer || adult astrocytic tumour || cell type cancer || endometrial carcinoma || salivary gland adenoid cystic carcinoma || chondrosarcoma || prostate cancer || reproductive organ cancer || breast cancer |
| Thyroglobulin type-1 domain | 0.03882 | INHERITED FROM: retinal cell cancer || kidney cancer || renal cell carcinoma || retinal cancer || renal carcinoma |
| SOCS box-like | 0.04676 | INHERITED FROM: chronic myeloid leukemia |
| BRCT domain | 0.04755 | INHERITED FROM: sporadic breast cancer |
| Ran binding protein zinc finger-like | 0.06743 | INHERITED FROM: retinal cell cancer || retinal cancer || sensory system cancer || sarcoma |
| Blood coagulation inhibitor (disintegrin) | 0.08774 | INHERITED FROM: basal cell carcinoma || breast carcinoma || skin carcinoma |
| Galactose-binding domain-like | 0.1059 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Protein kinase-like (PK-like) | 0.1694 | INHERITED FROM: organ system cancer || bile duct adenocarcinoma || lung carcinoma || retinal cell cancer || rhabdomyosarcoma || liver carcinoma || large intestine cancer || thoracic cancer || cervical adenocarcinoma || sensory system cancer || breast cancer || malignant glioma |
| Kringle-like | 0.1789 | INHERITED FROM: pancreatic adenocarcinoma || pancreatic ductal adenocarcinoma || thymoma || lung carcinoma || Hodgkin's lymphoma || meningioma || bone cancer || laryngeal carcinoma || invasive ductal carcinoma || connective tissue cancer || thymus cancer |
| Toll/Interleukin receptor TIR domain | 0.2125 | INHERITED FROM: mature T-cell and NK-cell lymphoma || mycosis fungoides |
| Notch domain | 0.2253 | INHERITED FROM: urinary system cancer || liver cancer || liver carcinoma || kidney cancer || renal cell carcinoma || lymphoblastic leukemia || renal carcinoma |
| Thioredoxin-like | 0.2257 | INHERITED FROM: oligodendroglioma |
| A DNA-binding domain in eukaryotic transcription factors | 0.2401 | INHERITED FROM: immune system cancer || hematologic cancer |
| p53-like transcription factors | 0.2519 | INHERITED FROM: breast adenocarcinoma || B-cell lymphoma || colon cancer || musculoskeletal system cancer || chronic leukemia || hematologic cancer || renal cell carcinoma || head and neck cancer || head and neck carcinoma || mammary Paget's disease || cervix carcinoma || salivary gland adenoid cystic carcinoma || Burkitt lymphoma || laryngeal carcinoma || connective tissue cancer |
| Nucleotide-diphospho-sugar transferases | 0.2519 | INHERITED FROM: prostate adenocarcinoma |
| Defensin-like | 0.3041 | INHERITED FROM: mature T-cell and NK-cell lymphoma || mycosis fungoides || non-Hodgkin lymphoma |
| Prefoldin | 0.3438 | INHERITED FROM: pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma || neuroendocrine carcinoma |
| STAT | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
| Transcription factor STAT-4 N-domain | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
| TSP-1 type 1 repeat | 0.3847 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| MHC antigen-recognition domain | 0.4055 | INHERITED FROM: leukemia || chronic myeloid leukemia || liver carcinoma |
| Interleukin 8-like chemokines | 0.4386 | INHERITED FROM: mature T-cell and NK-cell lymphoma |
| Trypsin-like serine proteases | 0.4588 | INHERITED FROM: pancreatic ductal adenocarcinoma |
| Immunoglobulin | 0.538 | INHERITED FROM: immune system cancer || endometrial stromal sarcoma || fibrosarcoma of bone |
| ABC transporter transmembrane region | 0.5448 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
| DNA repair protein MutS, domain III | 0.5768 | INHERITED FROM: urinary system cancer |
| Nucleoside diphosphate kinase, NDK | 0.5768 | INHERITED FROM: myeloid leukemia |
| TNF-like | 0.5979 | INHERITED FROM: B-cell lymphoma || Burkitt lymphoma || myeloid neoplasm |
| Cystine-knot cytokines | 0.6231 | INHERITED FROM: basal cell carcinoma || myelofibrosis || rhabdomyosarcoma || skeletal muscle cancer || prostate cancer || reproductive organ cancer |
| SAM/Pointed domain | 0.6437 | INHERITED FROM: invasive ductal carcinoma |
| Cytokine | 0.6464 | INHERITED FROM: Hodgkin's lymphoma |
| Leucine zipper domain | 0.703 | INHERITED FROM: hematologic cancer |
| EF-hand | 0.7255 | INHERITED FROM: keratoacanthoma |
| DPP6 N-terminal domain-like | 0.7451 | INHERITED FROM: meningioma || central nervous system cancer || chronic lymphocytic leukemia |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7656 | INHERITED FROM: endometrial cancer || hereditary Wilms' tumor || endometrial carcinoma |
| alpha/beta-Hydrolases | 0.769 | INHERITED FROM: meningioma || central nervous system cancer |
| Ubiquitin-like | 0.7784 | INHERITED FROM: pilocytic astrocytoma |
| Cyclin-like | 0.8019 | INHERITED FROM: retinal cell cancer || pharynx cancer || retinal cancer || sensory system cancer || laryngeal carcinoma |
| SH2 domain | 0.8102 | INHERITED FROM: organ system cancer || chronic myeloid leukemia || myelodysplastic/myeloproliferative neoplasm || breast cancer |
| Second domain of FERM | 0.8207 | INHERITED FROM: meningioma |
| FnI-like domain | 0.8385 | INHERITED FROM: peripheral nerve sheath neoplasm || neurofibroma |
| Ankyrin repeat | 0.8616 | INHERITED FROM: rhabdomyosarcoma || skeletal muscle cancer |
| Frizzled cysteine-rich domain | 0.8655 | INHERITED FROM: multiple myeloma || myeloid leukemia || myeloid neoplasm |
| Intermediate filament protein, coiled coil region | 0.8944 | INHERITED FROM: pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma || neuroendocrine carcinoma |
| HD-domain/PDEase-like | 0.9516 | INHERITED FROM: lymphoblastic leukemia || chronic lymphocytic leukemia |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Triple coiled coil domain of C-type lectins | 0 | Direct |
| Proteasome activator | 0 | Direct |
| DNA clamp | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| ACP-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| HIT-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| CCHHC domain | 0 | Direct |
| GroES-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| BTG domain-like | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| SRF-like | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| PAZ domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Orange domain-like | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Metallothionein | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Sialidases | 0 | Direct |
| Uteroglobin-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| Annexin | 0 | Direct |
| Synuclein | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| BAG domain | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Flavoproteins | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0.000008326 | Direct |
| Integrin domains | 0.001337 | Inherited |
| PGBD-like | 0.004991 | Inherited |
| TIMP-like | 0.006887 | Inherited |
| Growth factor receptor domain | 0.007903 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.008789 | Inherited |
| HMG-box | 0.01041 | Inherited |
| Caspase-like | 0.01303 | Inherited |
| Arginase/deacetylase | 0.01303 | Inherited |
| 4-helical cytokines | 0.0208 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.02485 | Inherited |
| TNF receptor-like | 0.02899 | Inherited |
| Snake toxin-like | 0.03705 | Inherited |
| Hemopexin-like domain | 0.03705 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.03841 | Inherited |
| Thyroglobulin type-1 domain | 0.03882 | Inherited |
| SOCS box-like | 0.04676 | Inherited |
| BRCT domain | 0.04755 | Inherited |
| Ran binding protein zinc finger-like | 0.06743 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.08774 | Inherited |
| Galactose-binding domain-like | 0.1059 | Inherited |
| Protein kinase-like (PK-like) | 0.1694 | Inherited |
| Kringle-like | 0.1789 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2125 | Inherited |
| Notch domain | 0.2253 | Inherited |
| Thioredoxin-like | 0.2257 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.2401 | Inherited |
| p53-like transcription factors | 0.2519 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.2519 | Inherited |
| Defensin-like | 0.3041 | Inherited |
| Prefoldin | 0.3438 | Inherited |
| STAT | 0.3797 | Inherited |
| Transcription factor STAT-4 N-domain | 0.3797 | Inherited |
| TSP-1 type 1 repeat | 0.3847 | Inherited |
| MHC antigen-recognition domain | 0.4055 | Inherited |
| Interleukin 8-like chemokines | 0.4386 | Inherited |
| Trypsin-like serine proteases | 0.4588 | Inherited |
| Immunoglobulin | 0.538 | Inherited |
| ABC transporter transmembrane region | 0.5448 | Inherited |
| DNA repair protein MutS, domain III | 0.5768 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.5768 | Inherited |
| TNF-like | 0.5979 | Inherited |
| Cystine-knot cytokines | 0.6231 | Inherited |
| SAM/Pointed domain | 0.6437 | Inherited |
| Cytokine | 0.6464 | Inherited |
| Leucine zipper domain | 0.703 | Inherited |
| EF-hand | 0.7255 | Inherited |
| DPP6 N-terminal domain-like | 0.7451 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7656 | Inherited |
| alpha/beta-Hydrolases | 0.769 | Inherited |
| Ubiquitin-like | 0.7784 | Inherited |
| Cyclin-like | 0.8019 | Inherited |
| SH2 domain | 0.8102 | Inherited |
| Second domain of FERM | 0.8207 | Inherited |
| FnI-like domain | 0.8385 | Inherited |
| Ankyrin repeat | 0.8616 | Inherited |
| Frizzled cysteine-rich domain | 0.8655 | Inherited |
| Intermediate filament protein, coiled coil region | 0.8944 | Inherited |
| HD-domain/PDEase-like | 0.9516 | Inherited |
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,50370
53448 - Nucleotide-diphospho-sugar transferases
50370 - Ricin B-like lectins | 0 | DIRECT |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | DIRECT |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
50044,56112
50044 - SH3-domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
50729,57863
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0 | DIRECT |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00121 | INHERITED FROM: endometrial cancer || thyroid cancer || thyroid carcinoma || endometrial carcinoma |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.004991 | INHERITED FROM: endometrial cancer || pancreatic ductal adenocarcinoma || bile duct adenocarcinoma || oral cavity cancer || head and neck squamous cell carcinoma || integumentary system cancer || carcinoma || liver carcinoma || kidney cancer || adult astrocytic tumour || renal cell carcinoma || cell type cancer || endometrial carcinoma || renal carcinoma || ovarian cancer || salivary gland adenoid cystic carcinoma || chondrosarcoma || myeloid neoplasm || prostate cancer || reproductive organ cancer || connective tissue cancer || breast cancer || ovary epithelial cancer || astrocytoma |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.006887 | INHERITED FROM: carcinoma || prostate carcinoma || chondrosarcoma || prostate cancer || reproductive organ cancer |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02238 | INHERITED FROM: pancreatic adenocarcinoma || immune system cancer || liver carcinoma || hematologic cancer || breast carcinoma || myeloid neoplasm || breast cancer |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.06464 | INHERITED FROM: pancreatic adenocarcinoma || pancreatic ductal adenocarcinoma || pancreatic cancer || breast ductal carcinoma || invasive ductal carcinoma |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.06464 | INHERITED FROM: melanoma |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.07678 | INHERITED FROM: immune system cancer |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.08774 | INHERITED FROM: basal cell carcinoma || breast carcinoma || skin carcinoma |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.08839 | INHERITED FROM: pancreatic adenocarcinoma || leukemia || hematologic cancer || breast carcinoma || pancreatic cancer || invasive ductal carcinoma |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.121 | INHERITED FROM: chronic myeloid leukemia |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.166 | INHERITED FROM: kidney cancer || renal cell carcinoma || lymphoblastic leukemia || bone marrow cancer || renal carcinoma |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.166 | INHERITED FROM: bone marrow cancer || myeloid neoplasm |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.1885 | INHERITED FROM: colon cancer || nasopharynx carcinoma |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.2401 | INHERITED FROM: immune system cancer || hematologic cancer |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.2519 | INHERITED FROM: meningioma |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.3041 | INHERITED FROM: pulmonary large cell neuroendocrine carcinoma || lung large cell carcinoma || neuroendocrine carcinoma |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0.3054 | INHERITED FROM: thoracic cancer || breast carcinoma || breast cancer |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3225 | INHERITED FROM: immune system cancer || endometrial stromal sarcoma || fibrosarcoma of bone |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.3811 | INHERITED FROM: meningioma |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.3938 | INHERITED FROM: leukemia || nasopharynx carcinoma |
81296,81296
81296 - E set domains
81296 - E set domains | 0.4177 | INHERITED FROM: male reproductive organ cancer || prostate cancer |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0.4708 | INHERITED FROM: nervous system cancer || meningioma || central nervous system cancer || lymphoblastic leukemia || chronic lymphocytic leukemia |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.5396 | INHERITED FROM: kidney cancer || renal cell carcinoma || renal carcinoma |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5448 | INHERITED FROM: myeloid leukemia || acute myeloid leukemia |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5768 | INHERITED FROM: urinary system cancer |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.8747 | INHERITED FROM: retinal cell cancer || hematologic cancer || retinal cancer || nasopharynx carcinoma || sensory system cancer || laryngeal carcinoma |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,50370
53448 - Nucleotide-diphospho-sugar transferases
50370 - Ricin B-like lectins | 0 | Direct |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | Direct |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
50044,56112
50044 - SH3-domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
50729,57863
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0 | Direct |
57302,57302
57302 - Snake toxin-like
57302 - Snake toxin-like | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00121 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.004991 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.006887 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02238 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.06464 | Inherited |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.06464 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.07678 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.08774 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.08839 | Inherited |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.121 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.166 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.166 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.1885 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.2401 | Inherited |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.2519 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.3041 | Inherited |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0.3054 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3225 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.3797 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3797 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.3797 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.3811 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.3938 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.4177 | Inherited |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0.4708 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.5396 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5448 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.5768 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.8747 | Inherited |
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01303 | INHERITED FROM: carcinoma || prostate carcinoma || chondrosarcoma || prostate cancer || reproductive organ cancer || ovary epithelial cancer |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.06464 | INHERITED FROM: kidney cancer || renal cell carcinoma || renal carcinoma |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.06854 | INHERITED FROM: renal carcinoma |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.2519 | INHERITED FROM: meningioma |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0.3054 | INHERITED FROM: thoracic cancer || breast carcinoma || breast cancer |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3797 | INHERITED FROM: chronic myeloid leukemia || chronic leukemia || head and neck cancer || head and neck carcinoma |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.4976 | INHERITED FROM: breast carcinoma |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.7516 | INHERITED FROM: fibrosarcoma of bone |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | Direct |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.01303 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.06464 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.06854 | Inherited |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.2519 | Inherited |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0.3054 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.3797 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.3797 | Inherited |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.4976 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.7516 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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