Disease Ontology (DO): immune system disease

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: disease [DOID:4] <8>

+ 1: disease of anatomical entity [DOID:7] <12> (143|187) (147|103|58)

0: immune system disease [DOID:2914] <4> (39|47) (42|27|16)

- 1: lymphatic system disease [DOID:75] <9> (4|7) (5|3|1)

- 1: primary immunodeficiency disease [DOID:612] <8> (6|3) (6|3|0)

- 1: hypersensitivity reaction disease [DOID:0060056] <5> (35|46) (37|23|14)

- 1: otulipenia [DOID:0080163] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
Anaphylotoxins (complement system)	0	Direct
Di-copper centre-containing domain	0	Direct
Immunoglobulin	0.000000000001216	Direct
4-helical cytokines	0.00000139	Direct
MHC antigen-recognition domain	0.00002223	Direct
TNF-like	0.0002339	Direct
TNF receptor-like	0.0003369	Direct
Notch domain	0.000695	Direct
PGBD-like	0.007887	Inherited
Integrin domains	0.01302	Inherited
Toll/Interleukin receptor TIR domain	0.01302	Inherited
Interleukin 8-like chemokines	0.0171	Inherited
DEATH domain	0.01758	Inherited
ABC transporter transmembrane region	0.01936	Inherited
Calcium-dependent phosphotriesterase	0.01949	Inherited
Hemopexin-like domain	0.02034	Inherited
Complement control module/SCR domain	0.02076	Inherited
Integrin beta tail domain	0.02212	Inherited
Transcription factor STAT-4 N-domain	0.02212	Inherited
STAT	0.02212	Inherited
Single hybrid motif	0.03865	Inherited
Bcl-2 inhibitors of programmed cell death	0.03941	Inherited
Transglutaminase, two C-terminal domains	0.04749	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.07615	Inherited
Riboflavin synthase domain-like	0.07615	Inherited
RNI-like	0.08276	Inherited
CoA-dependent acyltransferases	0.1057	Inherited
SMAD MH1 domain	0.1057	Inherited
Plexin repeat	0.1353	Inherited
Growth factor receptor domain	0.2234	Inherited
Cytokine	0.3033	Inherited
Cysteine proteinases	0.3489	Inherited
vWA-like	0.4428	Inherited
Metalloproteases ("zincins"), catalytic domain	0.4705	Inherited
E set domains	0.5939	Inherited
EGF/Laminin	0.5941	Inherited
SET domain	0.7409	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Serum paraoxonase/arylesterase 1, PON1	0	Direct
Netrin-like domain (NTR/C345C module)	0	Direct
Anaphylotoxins (complement system)	0	Direct
C1 set domains (antibody constant domain-like)	0.00000608	Direct
MHC antigen-recognition domain	0.00001613	Direct
Interferons/interleukin-10 (IL-10)	0.0001218	Direct
Short-chain cytokines	0.0001218	Direct
TNF-like	0.0001726	Direct
I set domains	0.0002352	Direct
Notch domain	0.0005121	Direct
TNF receptor-like	0.0006865	Direct
V set domains (antibody variable domain-like)	0.001235	Inherited
ABC transporter transmembrane region	0.001882	Inherited
Matrix metalloproteases, catalytic domain	0.005121	Inherited
C2 set domains	0.006409	Inherited
MMP N-terminal domain	0.006428	Inherited
Integrin domains	0.01015	Inherited
Toll/Interleukin receptor TIR domain	0.01015	Inherited
Interleukin 8-like chemokines	0.01381	Inherited
Cytochrome p450 reductase N-terminal domain-like	0.01485	Inherited
Interleukin-1 (IL-1)	0.01596	Inherited
Hemopexin-like domain	0.01604	Inherited
Complement control module/SCR domain	0.01686	Inherited
Integrin beta tail domain	0.01705	Inherited
STAT	0.01705	Inherited
Transcription factor STAT-4 N-domain	0.01705	Inherited
Integrin beta EGF-like domains	0.01705	Inherited
STAT DNA-binding domain	0.01705	Inherited
Bcl-2 inhibitors of programmed cell death	0.03138	Inherited
S100 proteins	0.03138	Inherited
Biotinyl/lipoyl-carrier proteins and domains	0.03234	Inherited
Transglutaminase N-terminal domain	0.03823	Inherited
Transglutaminase, two C-terminal domains	0.03823	Inherited
Platelet-derived growth factor-like	0.03823	Inherited
Pentraxin (pentaxin)	0.04421	Inherited
NADPH-cytochrome p450 reductase-like	0.04421	Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.04421	Inherited
Long-chain cytokines	0.05371	Inherited
Transglutaminase core	0.0688	Inherited
SMAD domain	0.08817	Inherited
SMAD MH1 domain	0.08817	Inherited
Growth factor receptor domain	0.1104	Inherited
Plexin repeat	0.1247	Inherited
Ankyrin repeat	0.1777	Inherited
Integrin A (or I) domain	0.3022	Inherited
EGF-type module	0.3582	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
Anaphylotoxins (complement system)	0	Direct
Di-copper centre-containing domain	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Immunoglobulin	0.0000000000005474	Direct
4-helical cytokines	0.0000007224	Direct
MHC antigen-recognition domain	0.00001249	Direct
TNF-like	0.0001404	Direct
TNF receptor-like	0.0002043	Direct
Notch domain	0.0004273	Direct
Kringle-like	0.0007947	Direct
PGBD-like	0.005433	Inherited
Integrin domains	0.009207	Inherited
Toll/Interleukin receptor TIR domain	0.009207	Inherited
Interleukin 8-like chemokines	0.01223	Inherited
DEATH domain	0.01261	Inherited
ABC transporter transmembrane region	0.014	Inherited
Calcium-dependent phosphotriesterase	0.01409	Inherited
Hemopexin-like domain	0.01473	Inherited
Complement control module/SCR domain	0.01504	Inherited
STAT	0.01608	Inherited
Integrin beta tail domain	0.01608	Inherited
Transcription factor STAT-4 N-domain	0.01608	Inherited
Single hybrid motif	0.02897	Inherited
Bcl-2 inhibitors of programmed cell death	0.0296	Inherited
Snake toxin-like	0.03485	Inherited
Transglutaminase, two C-terminal domains	0.03599	Inherited
Riboflavin synthase domain-like	0.0595	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.0595	Inherited
RNI-like	0.06502	Inherited
CoA-dependent acyltransferases	0.08417	Inherited
SMAD MH1 domain	0.08417	Inherited
Plexin repeat	0.1091	Inherited
Ankyrin repeat	0.1778	Inherited
Growth factor receptor domain	0.1859	Inherited
Cytokine	0.2584	Inherited
Cysteine proteinases	0.2998	Inherited
vWA-like	0.3856	Inherited
Metalloproteases ("zincins"), catalytic domain	0.4119	Inherited
E set domains	0.5276	Inherited
EGF/Laminin	0.5278	Inherited
SET domain	0.6691	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
49410,50242 49410 - Alpha-macroglobulin receptor domain 50242 - TIMP-like	0	Direct
90193,90193 90193 - Notch domain 90193 - Notch domain	0	Direct
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.000003914	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.00001338	Direct
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.000033	Direct
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.00004094	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.0002729	Direct
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.002167	Inherited
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.005433	Inherited
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.014	Inherited
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.01403	Inherited
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0.01608	Inherited
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.01608	Inherited
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0.01608	Inherited
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0.01608	Inherited
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.032	Inherited
54001,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains	0.03599	Inherited
81296,54001 81296 - E set domains 54001 - Cysteine proteinases	0.03599	Inherited
49309,49309 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains	0.03599	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.04953	Inherited
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.1504	Inherited
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.1516	Inherited
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1987	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.3813	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
47986,47986,52129 47986 - DEATH domain 47986 - DEATH domain 52129 - Caspase-like	0	Direct
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.001503	Inherited
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.001503	Inherited
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.004717	Inherited
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.01493	Inherited
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0.01608	Inherited
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0.01608	Inherited
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0.01608	Inherited
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.02603	Inherited
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.02934	Inherited
81296,54001,49309 81296 - E set domains 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains	0.03599	Inherited
54001,49309,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains	0.03599	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.07811	Inherited
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.2078	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Disease Ontology (DO): immune system disease

Superfamily

Family

Supra-domain (including individual superfamily)