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Disease Ontology (DO): disease of anatomical entity
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: DO Hierarchy (disease ontology from University of Maryland)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this DO term (Not in SDDO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| 4-helical cytokines | 0.00000007235 | DIRECT |
| Interleukin 8-like chemokines | 0.0000006025 | DIRECT |
| Voltage-gated potassium channels | 0.000008458 | DIRECT |
| Cystine-knot cytokines | 0.00004134 | DIRECT |
| Immunoglobulin | 0.0001493 | DIRECT |
| TNF-like | 0.0002426 | DIRECT |
| EGF/Laminin | 0.001067 | INHERITED FROM: atherosclerosis || vesiculobullous skin disease || blood coagulation disease || bullous pemphigoid || junctional epidermolysis bullosa || primary thrombocytopenia |
| Integrin domains | 0.001167 | INHERITED FROM: blood platelet disease || Glanzmann's thrombasthenia || hemorrhagic disease || thrombocytopenia || bullous pemphigoid || infertility |
| Toll/Interleukin receptor TIR domain | 0.001167 | INHERITED FROM: nasal cavity disease || dermatomyositis || myositis || allergic rhinitis || liver disease || atopic dermatitis || bone inflammation disease || hypersensitivity reaction disease || sarcoidosis || meningitis || nose disease || bronchiolitis obliterans || inflammatory bowel disease || alcoholic hepatitis || asthma || respiratory system disease |
| Cytokine | 0.001327 | INHERITED FROM: primary open angle glaucoma || tooth disease || contact dermatitis || periodontal disease || Behcet's disease || endometriosis || silicosis || open-angle glaucoma || purpura || bullous pemphigoid || obstructive lung disease || skin disease |
| Nuclear receptor ligand-binding domain | 0.001498 | INHERITED FROM: gallbladder disease || hypotrichosis || alopecia || endocrine pancreas disease || vascular disease |
| Complement control module/SCR domain | 0.002054 | INHERITED FROM: macular degeneration || glomerulonephritis || degeneration of macula and posterior pole || hematopoietic system disease || normocytic anemia || eye disease || hypersensitivity reaction type II disease |
| Intermediate filament protein, coiled coil region | 0.002489 | INHERITED FROM: integumentary system disease || palmoplantar keratosis |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.002948 | INHERITED FROM: nasal cavity disease || phagocyte bactericidal dysfunction || hypothyroidism || migraine || allergic rhinitis || lung disease || hypertension |
| Riboflavin synthase domain-like | 0.002948 | INHERITED FROM: nasal cavity disease || phagocyte bactericidal dysfunction || hypothyroidism || migraine || allergic rhinitis || lung disease || hypertension |
| Family A G protein-coupled receptor-like | 0.003489 | INHERITED FROM: migraine || lower respiratory tract disease || asthma |
| MHC antigen-recognition domain | 0.003503 | INHERITED FROM: neuromuscular junction disease || intrahepatic cholestasis || nasal cavity disease || integumentary system disease || demyelinating disease || hematopoietic system disease || vasculitis || hypotrichosis || spondylitis || allergic rhinitis || alopecia || hemorrhagic disease || connective tissue disease || vascular hemostatic disease || thyroiditis || Behcet's disease || liver disease || autoimmune disease of endocrine system || rheumatic fever || lymph node disease || bone inflammation disease || Graves' disease || sarcoidosis || gastrointestinal system disease || multiple sclerosis || immune system disease || uveitis || skin disease || Kawasaki disease || pemphigus || neuromyelitis optica || hypersensitivity reaction type II disease |
| L domain-like | 0.003642 | INHERITED FROM: myopia || Bernard-Soulier syndrome |
| Cytochrome P450 | 0.00563 | INHERITED FROM: adrenal gland disease || cardiovascular system disease || hyperandrogenism || bone remodeling disease || sex differentiation disease |
| FnI-like domain | 0.006278 | INHERITED FROM: cardiovascular system disease || arthritis || Ehlers-Danlos syndrome || musculoskeletal system disease || lung disease |
| Metalloproteases ("zincins"), catalytic domain | 0.00794 | INHERITED FROM: atherosclerosis || artery disease || tooth disease || mouth disease || cardiovascular system disease || otitis media || intrinsic cardiomyopathy || female reproductive system disease || refractive error || abdominal aortic aneurysm || lymph node disease || myopia || arteriosclerotic cardiovascular disease || middle ear disease || Kawasaki disease |
| ABC transporter transmembrane region | 0.00809 | INHERITED FROM: intrahepatic cholestasis || biliary tract disease || sclerosing cholangitis || bronchiectasis || primary biliary cirrhosis || hypersensitivity reaction disease || diarrhea || leukodystrophy || brain disease || adrenoleukodystrophy |
| Trypsin-like serine proteases | 0.008727 | INHERITED FROM: inherited blood coagulation disease || hematopoietic system disease || hereditary angioedema |
| Aquaporin-like | 0.01724 | INHERITED FROM: peripheral vertigo || Meniere's disease || female reproductive system disease || vestibular disease || inner ear disease || bowel dysfunction || uterine disease || sensory system disease || placenta disease |
| gamma-Crystallin-like | 0.01724 | INHERITED FROM: lens disease || eye and adnexa disease || nervous system disease || sensory system disease || eye disease |
| Serpins | 0.01808 | INHERITED FROM: chronic kidney disease || thrombophilia || vascular disease |
| vWA-like | 0.02155 | INHERITED FROM: dermatitis herpetiformis || thrombocytopenia || bullous pemphigoid |
| Snake toxin-like | 0.02192 | INHERITED FROM: abdominal aortic aneurysm || asthma |
| DEATH domain | 0.02303 | INHERITED FROM: spondyloarthropathy || bone inflammation disease || autoimmune lymphoproliferative syndrome || bone disease || familial Mediterranean fever || inflammatory bowel disease |
| Integrin alpha N-terminal domain | 0.02577 | INHERITED FROM: infertility |
| Fibronectin type III | 0.03213 | INHERITED FROM: demyelinating disease || acute kidney failure |
| Transglutaminase, two C-terminal domains | 0.04055 | INHERITED FROM: autoimmune disease of skin and connective tissue || integumentary system disease || bullous skin disease || dermatitis herpetiformis || skin disease |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.04055 | INHERITED FROM: vascular disease |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.04055 | INHERITED FROM: cardiovascular system disease || vascular disease |
| TSP-1 type 1 repeat | 0.04612 | INHERITED FROM: arthritis || connective tissue disease |
| Periplasmic binding protein-like II | 0.05683 | INHERITED FROM: lateral sclerosis || amyotrophic lateral sclerosis || nervous system disease || temporal lobe epilepsy |
| Spectrin repeat | 0.05983 | INHERITED FROM: muscle tissue disease || vesiculobullous skin disease || muscular disease |
| Globin-like | 0.0603 | INHERITED FROM: anemia |
| Multidrug efflux transporter AcrB transmembrane domain | 0.06205 | INHERITED FROM: coronary artery disease |
| Transcription factor STAT-4 N-domain | 0.06205 | INHERITED FROM: glomerulonephritis || Sjogren's syndrome || colitis || lower respiratory tract disease || intestinal disease || nephritis || inflammatory bowel disease || asthma || respiratory system disease |
| SMAD MH1 domain | 0.06205 | INHERITED FROM: glomerulonephritis || scleroderma || collagen disease || kidney disease || nephritis || rheumatic disease |
| STAT | 0.06205 | INHERITED FROM: glomerulonephritis || Sjogren's syndrome || colitis || lower respiratory tract disease || intestinal disease || nephritis || inflammatory bowel disease || asthma || respiratory system disease |
| C-type lectin-like | 0.06676 | INHERITED FROM: bronchitis || glomerulonephritis |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.08553 | INHERITED FROM: gallbladder disease |
| Lipoxigenase | 0.09532 | INHERITED FROM: integumentary system disease || ichthyosis || skin disease |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.09814 | INHERITED FROM: atherosclerosis || ichthyosis || arteriosclerotic cardiovascular disease || pancreatitis |
| Periplasmic binding protein-like I | 0.0983 | INHERITED FROM: amyotrophic lateral sclerosis || nervous system disease || motor neuron disease || epilepsy || temporal lobe epilepsy |
| TIMP-like | 0.1031 | INHERITED FROM: macular degeneration || tooth disease || degeneration of macula and posterior pole || intracranial arterial disease || intracranial aneurysm || arthritis || periodontal disease || connective tissue disease || bone inflammation disease || periodontitis || musculoskeletal system disease |
| Growth factor receptor domain | 0.1059 | INHERITED FROM: autoimmune disease of blood || primary thrombocytopenia |
| Hemopexin-like domain | 0.1336 | INHERITED FROM: atherosclerosis || tooth disease || mouth disease || bronchiectasis || arthritis || intrinsic cardiomyopathy || scleroderma || female reproductive system disease || refractive error || reproductive system disease || abdominal aortic aneurysm || lymph node disease || lymphatic system disease || myopia || lower respiratory tract disease || arteriosclerotic cardiovascular disease || lung disease || Kawasaki disease |
| SEA domain | 0.1349 | INHERITED FROM: laryngeal disease |
| Bcl-2 inhibitors of programmed cell death | 0.1349 | INHERITED FROM: Graves' disease || toxic encephalopathy |
| Cupredoxins | 0.1349 | INHERITED FROM: blood platelet disease || hemorrhagic disease || connective tissue disease |
| RuvA domain 2-like | 0.1453 | INHERITED FROM: hematopoietic system disease |
| Calcium-dependent phosphotriesterase | 0.1453 | INHERITED FROM: lateral sclerosis || amyotrophic lateral sclerosis || celiac disease || coronary artery disease || motor neuron disease || autoimmune disease of gastrointestinal tract |
| Triple coiled coil domain of C-type lectins | 0.1453 | INHERITED FROM: nasal cavity disease || allergic rhinitis || upper respiratory tract disease || interstitial lung disease || lower respiratory tract disease || nose disease || lung disease || asthma || respiratory system disease |
| Notch domain | 0.1453 | INHERITED FROM: autoimmune disease of blood || blood coagulation disease || hemorrhagic disease || hypersensitivity reaction disease || purpura || immune system disease || primary thrombocytopenia || hypersensitivity reaction type II disease |
| MAPEG domain-like | 0.1453 | INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease |
| Phospholipase A2, PLA2 | 0.1453 | INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease |
| p53-like transcription factors | 0.1605 | INHERITED FROM: cheilitis || colitis || lip disease || gastritis || Barrett's esophagus || intestinal disease || inflammatory bowel disease |
| CoA-dependent acyltransferases | 0.1754 | INHERITED FROM: primary biliary cirrhosis || autoimmune disease of urogenital tract |
| Kringle-like | 0.2026 | INHERITED FROM: atherosclerosis || artery disease || tooth disease || dermatomyositis || arteriosclerosis || pulmonary fibrosis || periodontal disease || female reproductive system disease || carotid stenosis || liver disease || salivary gland disease || myopia || endometriosis || kidney disease || leukodystrophy || arteriosclerotic cardiovascular disease || meningitis || urinary system disease || vascular disease || cholesteatoma || myocardial infarction |
| SH2 domain | 0.2106 | INHERITED FROM: bone marrow disease |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2198 | INHERITED FROM: brain disease |
| ACT-like | 0.2198 | INHERITED FROM: brain disease |
| PRTase-like | 0.2198 | INHERITED FROM: arthritis || gout |
| Restriction endonuclease-like | 0.2198 | INHERITED FROM: hematopoietic system disease |
| Fibrinogen C-terminal domain-like | 0.2334 | INHERITED FROM: congenital afibrinogenemia |
| YWTD domain | 0.2347 | INHERITED FROM: artery disease || cardiovascular system disease || Alzheimer's disease || tauopathy || vascular disease |
| Blood coagulation inhibitor (disintegrin) | 0.2347 | INHERITED FROM: atherosclerosis || artery disease || arteriosclerotic cardiovascular disease |
| Class II aaRS and biotin synthetases | 0.243 | INHERITED FROM: neuromuscular disease || Charcot-Marie-Tooth disease |
| Alpha-macroglobulin receptor domain | 0.2435 | INHERITED FROM: tooth disease || mouth disease || periodontal disease || psoriasis || periodontitis || proteinuria |
| Inhibitor of apoptosis (IAP) repeat | 0.2435 | INHERITED FROM: demyelinating disease || multiple sclerosis |
| Thioredoxin-like | 0.2512 | INHERITED FROM: congenital hemolytic anemia || Pick's disease |
| Protein kinase-like (PK-like) | 0.2608 | INHERITED FROM: ataxia telangiectasia || synostosis |
| RNI-like | 0.3129 | INHERITED FROM: Crohn's disease || nasal cavity disease || uveal disease || panuveitis || allergic rhinitis || bronchiolitis || bone inflammation disease || periodontitis || sarcoidosis || nose disease || uveitis || inflammatory bowel disease |
| Terpenoid cyclases/Protein prenyltransferases | 0.3181 | INHERITED FROM: tooth disease || mouth disease || periodontal disease || psoriasis || periodontitis || proteinuria |
| PGBD-like | 0.3257 | INHERITED FROM: atherosclerosis || tooth disease || mouth disease || bronchiectasis || dermatomyositis || arthritis || myositis || intrinsic cardiomyopathy || scleroderma || female reproductive system disease || refractive error || Barrett's esophagus || reproductive system disease || abdominal aortic aneurysm || lymph node disease || myopia || lower respiratory tract disease || aortic disease || gastrointestinal system disease || arteriosclerotic cardiovascular disease || lung disease || Kawasaki disease || respiratory system disease |
| Proton glutamate symport protein | 0.3333 | INHERITED FROM: demyelinating disease || multiple sclerosis |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.368 | INHERITED FROM: early myoclonic encephalopathy || Lewy body dementia || nervous system disease || frontal lobe epilepsy |
| Nicotinic receptor ligand binding domain-like | 0.368 | INHERITED FROM: early myoclonic encephalopathy || Lewy body dementia || nervous system disease || frontal lobe epilepsy |
| Thyroglobulin type-1 domain | 0.3927 | INHERITED FROM: hypothyroidism || thyroid gland disease |
| Defensin-like | 0.4113 | INHERITED FROM: tooth disease || periodontal disease || gastritis || atopic dermatitis || periodontitis || dermatitis |
| Myosin rod fragments | 0.5089 | INHERITED FROM: dilated cardiomyopathy |
| Single hybrid motif | 0.5233 | INHERITED FROM: liver cirrhosis || primary biliary cirrhosis || autoimmune disease of urogenital tract |
| Nudix | 0.5233 | INHERITED FROM: lateral sclerosis || amyotrophic lateral sclerosis || motor neuron disease |
| Cysteine proteinases | 0.5533 | INHERITED FROM: autoimmune disease of skin and connective tissue || dermatitis herpetiformis |
| Mitochondrial carrier | 0.5578 | INHERITED FROM: peripheral nervous system disease || diabetic neuropathy |
| MFS general substrate transporter | 0.5714 | INHERITED FROM: hypoglycemia |
| Annexin | 0.6176 | INHERITED FROM: ischemic bone disease || osteonecrosis |
| Plexin repeat | 0.6229 | INHERITED FROM: autoimmune disease of skin and connective tissue || bullous skin disease || dermatitis herpetiformis || bullous pemphigoid |
| E set domains | 0.6435 | INHERITED FROM: autoimmune disease of skin and connective tissue || dermatitis herpetiformis |
| SCOP hierarchy in SUPERFAMILY | 0.6507 | INHERITED FROM: ataxia telangiectasia |
| Cadherin-like | 0.7118 | INHERITED FROM: pemphigus |
| GST C-terminal domain-like | 0.7192 | INHERITED FROM: congenital hemolytic anemia || normocytic anemia || Barrett's esophagus || hemoglobinopathy |
| HSP20-like chaperones | 0.7397 | INHERITED FROM: peripheral nervous system disease |
| Homeodomain-like | 1 | INHERITED FROM: hypopituitarism || pituitary gland disease |
| PH domain-like | 1 | INHERITED FROM: centronuclear myopathy |
| RNA-binding domain, RBD | 1 | INHERITED FROM: transient cerebral ischemia || myopathy of extraocular muscle |
| SET domain | 1 | INHERITED FROM: phagocyte bactericidal dysfunction |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: hereditary multiple exostoses || exostosis |
| ARM repeat | 1 | INHERITED FROM: Peutz-Jeghers syndrome |
| GTPase activation domain, GAP | 1 | INHERITED FROM: bone marrow disease |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| PA domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Hairpin loop containing domain-like | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Flavoproteins | 0 | Direct |
| BPTI-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| SRF-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| 4-helical cytokines | 0.00000007235 | Direct |
| Interleukin 8-like chemokines | 0.0000006025 | Direct |
| Voltage-gated potassium channels | 0.000008458 | Direct |
| Cystine-knot cytokines | 0.00004134 | Direct |
| Immunoglobulin | 0.0001493 | Direct |
| TNF-like | 0.0002426 | Direct |
| EGF/Laminin | 0.001067 | Inherited |
| Integrin domains | 0.001167 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.001167 | Inherited |
| Cytokine | 0.001327 | Inherited |
| Nuclear receptor ligand-binding domain | 0.001498 | Inherited |
| Complement control module/SCR domain | 0.002054 | Inherited |
| Intermediate filament protein, coiled coil region | 0.002489 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.002948 | Inherited |
| Riboflavin synthase domain-like | 0.002948 | Inherited |
| Family A G protein-coupled receptor-like | 0.003489 | Inherited |
| MHC antigen-recognition domain | 0.003503 | Inherited |
| L domain-like | 0.003642 | Inherited |
| Cytochrome P450 | 0.00563 | Inherited |
| FnI-like domain | 0.006278 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.00794 | Inherited |
| ABC transporter transmembrane region | 0.00809 | Inherited |
| Trypsin-like serine proteases | 0.008727 | Inherited |
| Aquaporin-like | 0.01724 | Inherited |
| gamma-Crystallin-like | 0.01724 | Inherited |
| Serpins | 0.01808 | Inherited |
| vWA-like | 0.02155 | Inherited |
| Snake toxin-like | 0.02192 | Inherited |
| DEATH domain | 0.02303 | Inherited |
| Integrin alpha N-terminal domain | 0.02577 | Inherited |
| Fibronectin type III | 0.03213 | Inherited |
| Transglutaminase, two C-terminal domains | 0.04055 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.04055 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.04055 | Inherited |
| TSP-1 type 1 repeat | 0.04612 | Inherited |
| Periplasmic binding protein-like II | 0.05683 | Inherited |
| Spectrin repeat | 0.05983 | Inherited |
| Globin-like | 0.0603 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.06205 | Inherited |
| Transcription factor STAT-4 N-domain | 0.06205 | Inherited |
| SMAD MH1 domain | 0.06205 | Inherited |
| STAT | 0.06205 | Inherited |
| C-type lectin-like | 0.06676 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.08553 | Inherited |
| Lipoxigenase | 0.09532 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.09814 | Inherited |
| Periplasmic binding protein-like I | 0.0983 | Inherited |
| TIMP-like | 0.1031 | Inherited |
| Growth factor receptor domain | 0.1059 | Inherited |
| Hemopexin-like domain | 0.1336 | Inherited |
| SEA domain | 0.1349 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.1349 | Inherited |
| Cupredoxins | 0.1349 | Inherited |
| RuvA domain 2-like | 0.1453 | Inherited |
| Calcium-dependent phosphotriesterase | 0.1453 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.1453 | Inherited |
| Notch domain | 0.1453 | Inherited |
| MAPEG domain-like | 0.1453 | Inherited |
| Phospholipase A2, PLA2 | 0.1453 | Inherited |
| p53-like transcription factors | 0.1605 | Inherited |
| CoA-dependent acyltransferases | 0.1754 | Inherited |
| Kringle-like | 0.2026 | Inherited |
| SH2 domain | 0.2106 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2198 | Inherited |
| ACT-like | 0.2198 | Inherited |
| PRTase-like | 0.2198 | Inherited |
| Restriction endonuclease-like | 0.2198 | Inherited |
| Fibrinogen C-terminal domain-like | 0.2334 | Inherited |
| YWTD domain | 0.2347 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.2347 | Inherited |
| Class II aaRS and biotin synthetases | 0.243 | Inherited |
| Alpha-macroglobulin receptor domain | 0.2435 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.2435 | Inherited |
| Thioredoxin-like | 0.2512 | Inherited |
| Protein kinase-like (PK-like) | 0.2608 | Inherited |
| RNI-like | 0.3129 | Inherited |
| Terpenoid cyclases/Protein prenyltransferases | 0.3181 | Inherited |
| PGBD-like | 0.3257 | Inherited |
| Proton glutamate symport protein | 0.3333 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.368 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.368 | Inherited |
| Thyroglobulin type-1 domain | 0.3927 | Inherited |
| Defensin-like | 0.4113 | Inherited |
| Myosin rod fragments | 0.5089 | Inherited |
| Single hybrid motif | 0.5233 | Inherited |
| Nudix | 0.5233 | Inherited |
| Cysteine proteinases | 0.5533 | Inherited |
| Mitochondrial carrier | 0.5578 | Inherited |
| MFS general substrate transporter | 0.5714 | Inherited |
| Annexin | 0.6176 | Inherited |
| Plexin repeat | 0.6229 | Inherited |
| E set domains | 0.6435 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.6507 | Inherited |
| Cadherin-like | 0.7118 | Inherited |
| GST C-terminal domain-like | 0.7192 | Inherited |
| HSP20-like chaperones | 0.7397 | Inherited |
| Homeodomain-like | 1 | Inherited |
| PH domain-like | 1 | Inherited |
| RNA-binding domain, RBD | 1 | Inherited |
| SET domain | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| ARM repeat | 1 | Inherited |
| GTPase activation domain, GAP | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this DO term (Not in SDDO)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Prokaryotic proteases | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| GRAM domain | 0 | DIRECT |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0 | DIRECT |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Retinol binding protein-like | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Netrin-like domain (NTR/C345C module) | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| Tetraspanin | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| BAFF receptor-like | 0 | DIRECT |
| MHCK/EF2 kinase | 0 | DIRECT |
| Interferon regulatory factor | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| Interleukin 17F, IL-17F | 0 | DIRECT |
| Interleukin-1 (IL-1) | 0 | DIRECT |
| Anti-sigma factor antagonist SpoIIaa | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Pentraxin (pentaxin) | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Leukotriene A4 hydrolase catalytic domain | 0 | DIRECT |
| Family 1 of glycosyl hydrolase | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Integrin beta EGF-like domains | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| HtrA-like serine proteases | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Type II chitinase | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Interleukin 8-like chemokines | 0.0000007824 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.0001591 | DIRECT |
| Integrin A (or I) domain | 0.0002506 | DIRECT |
| TNF-like | 0.0002506 | DIRECT |
| C1 set domains (antibody constant domain-like) | 0.0008985 | DIRECT |
| Integrin domains | 0.001083 | INHERITED FROM: blood platelet disease || Glanzmann's thrombasthenia || hemorrhagic disease || thrombocytopenia || bullous pemphigoid || infertility |
| ABC transporter ATPase domain-like | 0.001195 | INHERITED FROM: intrahepatic cholestasis || biliary tract disease || sclerosing cholangitis || bronchiectasis || leukodystrophy || adrenoleukodystrophy |
| Nuclear receptor ligand-binding domain | 0.001634 | INHERITED FROM: gallbladder disease || hypotrichosis || alopecia || endocrine pancreas disease || vascular disease |
| Complement control module/SCR domain | 0.002233 | INHERITED FROM: macular degeneration || glomerulonephritis || blood platelet disease || degeneration of macula and posterior pole || hematopoietic system disease || normocytic anemia || hemolytic-uremic syndrome || eye disease || hypersensitivity reaction type II disease |
| Interferons/interleukin-10 (IL-10) | 0.002576 | INHERITED FROM: spondyloarthropathy || muscle tissue disease || hepatitis || integumentary system disease || myositis || connective tissue disease || interstitial lung disease || IgA glomerulonephritis || pustulosis of palm and sole || liver disease || arthropathy || periodontitis || hypersensitivity reaction disease || sarcoidosis || dermatitis || immune system disease || nephritis || skin disease |
| Intermediate filament protein, coiled coil region | 0.002647 | INHERITED FROM: integumentary system disease || palmoplantar keratosis |
| Nuclear receptor | 0.003039 | INHERITED FROM: gallbladder disease || hypotrichosis || alopecia || endocrine pancreas disease || vascular disease |
| MHC antigen-recognition domain | 0.003539 | INHERITED FROM: neuromuscular junction disease || intrahepatic cholestasis || nasal cavity disease || integumentary system disease || demyelinating disease || hematopoietic system disease || vasculitis || hypotrichosis || spondylitis || allergic rhinitis || alopecia || hemorrhagic disease || connective tissue disease || vascular hemostatic disease || thyroiditis || Behcet's disease || liver disease || autoimmune disease of endocrine system || rheumatic fever || lymph node disease || bone inflammation disease || Graves' disease || sarcoidosis || gastrointestinal system disease || multiple sclerosis || nose disease || immune system disease || uveitis || skin disease || Kawasaki disease || pemphigus || neuromyelitis optica || hypersensitivity reaction type II disease |
| Rhodopsin-like | 0.004119 | INHERITED FROM: migraine || lower respiratory tract disease || asthma |
| Voltage-gated potassium channels | 0.005968 | INHERITED FROM: intrinsic cardiomyopathy || long QT syndrome || cardiomyopathy |
| Cytochrome P450 | 0.007916 | INHERITED FROM: adrenal gland disease || cardiovascular system disease |
| I set domains | 0.007999 | INHERITED FROM: craniosynostosis || acute kidney failure || bullous pemphigoid || immune system disease |
| Ngr ectodomain-like | 0.008423 | INHERITED FROM: corneal disease || inherited blood coagulation disease || myopia || Bernard-Soulier syndrome |
| Long-chain cytokines | 0.00979 | INHERITED FROM: uremia || artery disease || kidney failure || tooth disease || nasal cavity disease || celiac disease || allergic rhinitis || periodontal disease || female reproductive system disease || reproductive system disease || periodontitis || central nervous system disease || multiple sclerosis || nose disease || vascular disease |
| Transforming growth factor (TGF)-beta | 0.01465 | INHERITED FROM: keratopathy || ankylosis || hypogonadism || otosclerosis || reproductive system disease || colonic disease || Hirschsprung's disease || premature ovarian failure || corneal edema || hypertension |
| Tetramerization domain of potassium channels | 0.01497 | INHERITED FROM: epilepsy |
| Crystallins/Ca-binding development proteins | 0.01497 | INHERITED FROM: lens disease || eye and adnexa disease || nervous system disease || sensory system disease || eye disease |
| Aquaporin-like | 0.01497 | INHERITED FROM: peripheral vertigo || Meniere's disease || female reproductive system disease || vestibular disease || inner ear disease || bowel dysfunction || uterine disease || sensory system disease || placenta disease |
| Eukaryotic proteases | 0.01672 | INHERITED FROM: inherited blood coagulation disease || hematopoietic system disease || hereditary angioedema |
| Transglutaminase core | 0.02294 | INHERITED FROM: autoimmune disease of skin and connective tissue || integumentary system disease || bullous skin disease || dermatitis herpetiformis || skin disease |
| Serpins | 0.0239 | INHERITED FROM: chronic kidney disease || thrombophilia || severe pre-eclampsia || vascular disease |
| Integrin alpha N-terminal domain | 0.02405 | INHERITED FROM: infertility |
| EGF-type module | 0.02532 | INHERITED FROM: cardiovascular system disease || autoimmune disease of blood || blood coagulation disease || gastritis || abdominal aortic aneurysm || acute pancreatitis || primary thrombocytopenia |
| Glutathione peroxidase-like | 0.02586 | INHERITED FROM: Pick's disease || Parkinson's disease |
| ABC transporter transmembrane region | 0.02894 | INHERITED FROM: intrahepatic cholestasis || biliary tract disease || sclerosing cholangitis || bronchiectasis || primary biliary cirrhosis || epilepsy || hypersensitivity reaction disease || diarrhea |
| Transglutaminase N-terminal domain | 0.03569 | INHERITED FROM: autoimmune disease of skin and connective tissue || integumentary system disease || bullous skin disease || dermatitis herpetiformis || skin disease |
| Transglutaminase, two C-terminal domains | 0.03569 | INHERITED FROM: autoimmune disease of skin and connective tissue || integumentary system disease || bullous skin disease || dermatitis herpetiformis || skin disease |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.03569 | INHERITED FROM: cardiovascular system disease || vascular disease |
| Platelet-derived growth factor-like | 0.03569 | INHERITED FROM: atherosclerosis || scleroderma || collagen disease || arteriosclerotic cardiovascular disease || lung disease || rheumatic disease |
| Fibronectin type III | 0.04496 | INHERITED FROM: demyelinating disease || acute kidney failure |
| Laminin-type module | 0.04804 | INHERITED FROM: vesiculobullous skin disease || junctional epidermolysis bullosa |
| TSP-1 type 1 repeat | 0.04848 | INHERITED FROM: arthritis || connective tissue disease |
| STAT | 0.05509 | INHERITED FROM: glomerulonephritis || Sjogren's syndrome || colitis || lower respiratory tract disease || intestinal disease || nephritis || inflammatory bowel disease || asthma || respiratory system disease |
| Transcription factor STAT-4 N-domain | 0.05509 | INHERITED FROM: glomerulonephritis || Sjogren's syndrome || colitis || lower respiratory tract disease || intestinal disease || nephritis || inflammatory bowel disease || asthma || respiratory system disease |
| SMAD domain | 0.05509 | INHERITED FROM: glomerulonephritis || scleroderma || collagen disease || kidney disease || nephritis || rheumatic disease |
| Erythroid transcription factor GATA-1 | 0.05509 | INHERITED FROM: anemia || aplastic anemia |
| STAT DNA-binding domain | 0.05509 | INHERITED FROM: glomerulonephritis || Sjogren's syndrome || colitis || lower respiratory tract disease || intestinal disease || nephritis || inflammatory bowel disease || asthma || respiratory system disease |
| SMAD MH1 domain | 0.05509 | INHERITED FROM: glomerulonephritis || scleroderma || collagen disease || kidney disease || nephritis || rheumatic disease |
| Globins | 0.05528 | INHERITED FROM: hematopoietic system disease || anemia || pneumonia |
| Spectrin repeat | 0.05843 | INHERITED FROM: muscle tissue disease || vesiculobullous skin disease || muscular disease |
| DEATH domain, DD | 0.06086 | INHERITED FROM: gastritis |
| Growth factor receptor domain | 0.06762 | INHERITED FROM: glomerulonephritis || autoimmune disease of blood || interstitial lung disease || primary thrombocytopenia |
| Noncollagenous (NC1) domain of collagen IV | 0.0846 | INHERITED FROM: chronic kidney disease || glomerulonephritis || kidney disease || urinary system disease |
| Pancreatic lipase, N-terminal domain | 0.0846 | INHERITED FROM: atherosclerosis || arteriosclerosis || coronary artery disease || arteriosclerotic cardiovascular disease || pancreatitis || myocardial infarction || pancreas disease |
| L domain | 0.0846 | INHERITED FROM: neuropathy |
| Animal lipoxigenases | 0.0846 | INHERITED FROM: integumentary system disease || ichthyosis || skin disease |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.09242 | INHERITED FROM: hereditary ataxia || telangiectasis || autosomal recessive cerebellar ataxia || peripheral vascular disease || ataxia telangiectasia |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.114 | INHERITED FROM: neuromuscular disease || Charcot-Marie-Tooth disease || neuropathy |
| C2 set domains | 0.114 | INHERITED FROM: arthritis || demyelinating disease || hematopoietic system disease || connective tissue disease || nervous system disease || rheumatoid arthritis || bone inflammation disease || central nervous system disease || multiple sclerosis || nephritis || hypersensitivity reaction type II disease |
| Bcl-2 inhibitors of programmed cell death | 0.1264 | INHERITED FROM: Graves' disease || toxic encephalopathy |
| S100 proteins | 0.1264 | INHERITED FROM: connective tissue disease || lymph node disease || Kawasaki disease |
| Triple coiled coil domain of C-type lectins | 0.1297 | INHERITED FROM: nasal cavity disease || allergic rhinitis || upper respiratory tract disease || interstitial lung disease || lower respiratory tract disease || nose disease || lung disease || asthma || respiratory system disease |
| Notch domain | 0.1297 | INHERITED FROM: autoimmune disease of blood || blood coagulation disease || hemorrhagic disease || hypersensitivity reaction disease || purpura || immune system disease || primary thrombocytopenia || hypersensitivity reaction type II disease |
| Lipoxigenase N-terminal domain | 0.1297 | INHERITED FROM: ichthyosis |
| Hemopexin-like domain | 0.1307 | INHERITED FROM: atherosclerosis || tooth disease || mouth disease || bronchiectasis || arthritis || intrinsic cardiomyopathy || scleroderma || female reproductive system disease || refractive error || reproductive system disease || abdominal aortic aneurysm || lymph node disease || lymphatic system disease || bone inflammation disease || myopia || lower respiratory tract disease || aortic disease || arteriosclerotic cardiovascular disease || lung disease || Kawasaki disease |
| Phosphate binding protein-like | 0.1311 | INHERITED FROM: lateral sclerosis || amyotrophic lateral sclerosis || nervous system disease || epilepsy || temporal lobe epilepsy |
| Forkhead DNA-binding domain | 0.1621 | INHERITED FROM: congestive heart failure || premature ovarian failure |
| MIR domain | 0.1623 | INHERITED FROM: muscle tissue disease |
| Kringle modules | 0.1742 | INHERITED FROM: atherosclerosis || artery disease || cerebral degeneration || blood coagulation disease || leukodystrophy || arteriosclerotic cardiovascular disease || vascular disease || myocardial infarction |
| L-arabinose binding protein-like | 0.1924 | INHERITED FROM: amyotrophic lateral sclerosis || nervous system disease || motor neuron disease || epilepsy || temporal lobe epilepsy |
| C-type lectin domain | 0.1989 | INHERITED FROM: bronchitis || vasculitis || rheumatoid arthritis |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2003 | INHERITED FROM: brain disease |
| Exostosin | 0.2003 | INHERITED FROM: hereditary multiple exostoses || hyperostosis || exostosis || bone remodeling disease |
| XPF/Rad1/Mus81 nuclease | 0.2003 | INHERITED FROM: hematopoietic system disease |
| Phenylalanine metabolism regulatory domain | 0.2003 | INHERITED FROM: brain disease |
| DEATH effector domain, DED | 0.2003 | INHERITED FROM: lower respiratory tract disease || respiratory system disease |
| Blood coagulation inhibitor (disintegrin) | 0.2264 | INHERITED FROM: atherosclerosis || artery disease || arteriosclerotic cardiovascular disease |
| YWTD domain | 0.2264 | INHERITED FROM: artery disease || cardiovascular system disease || Alzheimer's disease || tauopathy || vascular disease |
| Complement components | 0.2274 | INHERITED FROM: tooth disease || mouth disease || demyelinating disease || periodontal disease || psoriasis || periodontitis || proteinuria || multiple sclerosis |
| Penta-EF-hand proteins | 0.2274 | INHERITED FROM: muscle tissue disease || muscular dystrophy || muscular disease |
| Alpha-macroglobulin receptor domain | 0.2274 | INHERITED FROM: tooth disease || mouth disease || demyelinating disease || periodontal disease || psoriasis || periodontitis || proteinuria || multiple sclerosis |
| Inhibitor of apoptosis (IAP) repeat | 0.2274 | INHERITED FROM: demyelinating disease || multiple sclerosis |
| EF-hand modules in multidomain proteins | 0.2307 | INHERITED FROM: muscular dystrophy || Duchenne muscular dystrophy |
| Fibrinogen C-terminal domain-like | 0.2347 | INHERITED FROM: congenital afibrinogenemia |
| SH2 domain | 0.2415 | INHERITED FROM: bone marrow disease |
| Myosin rod fragments | 0.2764 | INHERITED FROM: dilated cardiomyopathy |
| Matrix metalloproteases, catalytic domain | 0.3034 | INHERITED FROM: atherosclerosis || tooth disease || mouth disease || bronchiectasis || dermatomyositis || myositis || intrinsic cardiomyopathy || scleroderma || female reproductive system disease || refractive error || Barrett's esophagus || reproductive system disease || abdominal aortic aneurysm || lymph node disease || lymphatic system disease || myopia || lower respiratory tract disease || aortic disease || gastrointestinal system disease || arteriosclerotic cardiovascular disease || lung disease || Kawasaki disease || respiratory system disease |
| VWC domain | 0.3066 | INHERITED FROM: Ehlers-Danlos syndrome |
| Pyrin domain, PYD | 0.3158 | INHERITED FROM: Crohn's disease || intestinal disease || inflammatory bowel disease |
| Proton glutamate symport protein | 0.3158 | INHERITED FROM: demyelinating disease || multiple sclerosis |
| MMP N-terminal domain | 0.3223 | INHERITED FROM: atherosclerosis || tooth disease || mouth disease || bronchiectasis || dermatomyositis || arthritis || myositis || intrinsic cardiomyopathy || scleroderma || female reproductive system disease || refractive error || Barrett's esophagus || reproductive system disease || abdominal aortic aneurysm || lymph node disease || bone inflammation disease || myopia || lower respiratory tract disease || aortic disease || gastrointestinal system disease || arteriosclerotic cardiovascular disease || lung disease || Kawasaki disease || respiratory system disease |
| Protein kinases, catalytic subunit | 0.3602 | INHERITED FROM: synostosis |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3872 | INHERITED FROM: early myoclonic encephalopathy || Lewy body dementia || nervous system disease || brain disease || frontal lobe epilepsy |
| Nicotinic receptor ligand binding domain-like | 0.3872 | INHERITED FROM: early myoclonic encephalopathy || Lewy body dementia || nervous system disease || brain disease || frontal lobe epilepsy |
| Caspase recruitment domain, CARD | 0.3916 | INHERITED FROM: Crohn's disease || colitis |
| Thyroglobulin type-1 domain | 0.3916 | INHERITED FROM: hypothyroidism || thyroid gland disease |
| Defensin | 0.3977 | INHERITED FROM: tooth disease || periodontal disease || gastritis || atopic dermatitis || periodontitis || dermatitis |
| V set domains (antibody variable domain-like) | 0.4092 | INHERITED FROM: cholangitis || demyelinating disease || lymphopenia || hypersensitivity reaction disease || multiple sclerosis |
| Sir2 family of transcriptional regulators | 0.4298 | INHERITED FROM: lung disease |
| Fibronectin type II module | 0.4605 | INHERITED FROM: atherosclerosis || acute myocardial infarction || arteriosclerosis || coronary artery disease || aortic disease || arteriosclerotic cardiovascular disease || myocardial infarction |
| Biotinyl/lipoyl-carrier proteins and domains | 0.5061 | INHERITED FROM: liver cirrhosis || primary biliary cirrhosis || autoimmune disease of urogenital tract |
| 28-residue LRR | 0.5091 | INHERITED FROM: Crohn's disease || nasal cavity disease || allergic rhinitis || nose disease || inflammatory bowel disease |
| Mitochondrial carrier | 0.5523 | INHERITED FROM: peripheral nervous system disease || diabetic neuropathy |
| Annexin | 0.6061 | INHERITED FROM: ischemic bone disease || osteonecrosis |
| T-box | 0.6061 | INHERITED FROM: congenital heart disease |
| Motor proteins | 0.6063 | INHERITED FROM: sensorineural hearing loss || inner ear disease || auditory system disease |
| Glutathione S-transferase (GST), C-terminal domain | 0.6205 | INHERITED FROM: congenital hemolytic anemia || normocytic anemia || Barrett's esophagus || hemoglobinopathy |
| Plexin repeat | 0.6289 | INHERITED FROM: autoimmune disease of skin and connective tissue || bullous skin disease || dermatitis herpetiformis || bullous pemphigoid |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.6422 | INHERITED FROM: endometriosis |
| Calmodulin-like | 0.651 | INHERITED FROM: epilepsy |
| FAD-linked reductases, N-terminal domain | 0.6733 | INHERITED FROM: muscle tissue disease |
| Ankyrin repeat | 0.6801 | INHERITED FROM: primary thrombocytopenia |
| Cadherin | 0.8709 | INHERITED FROM: hypotrichosis || pemphigus |
| BCR-homology GTPase activation domain (BH-domain) | 0.8898 | INHERITED FROM: bone marrow disease |
| Phosphotyrosine-binding domain (PTB) | 0.9686 | INHERITED FROM: hyperandrogenism || sex differentiation disease |
| SPRY domain | 0.9977 | INHERITED FROM: Behcet's disease |
| Homeodomain | 1 | INHERITED FROM: hypopituitarism || pituitary gland disease |
| Canonical RBD | 1 | INHERITED FROM: transient cerebral ischemia || myopathy of extraocular muscle |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| SRF-like | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Thrombospondin C-terminal domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Prokaryotic proteases | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Pepsin-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| GRAM domain | 0 | Direct |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0 | Direct |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
| Insulin-like | 0 | Direct |
| Retinol binding protein-like | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Netrin-like domain (NTR/C345C module) | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| PA domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| Transferrin | 0 | Direct |
| Neurotrophin | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| Tetraspanin | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| BAFF receptor-like | 0 | Direct |
| MHCK/EF2 kinase | 0 | Direct |
| Interferon regulatory factor | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| Interleukin 17F, IL-17F | 0 | Direct |
| Interleukin-1 (IL-1) | 0 | Direct |
| Anti-sigma factor antagonist SpoIIaa | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Pentraxin (pentaxin) | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Leukotriene A4 hydrolase catalytic domain | 0 | Direct |
| Family 1 of glycosyl hydrolase | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Integrin beta EGF-like domains | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| HtrA-like serine proteases | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Type II chitinase | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Interleukin 8-like chemokines | 0.0000007824 | Direct |
| Toll/Interleukin receptor TIR domain | 0.0001591 | Direct |
| Integrin A (or I) domain | 0.0002506 | Direct |
| TNF-like | 0.0002506 | Direct |
| C1 set domains (antibody constant domain-like) | 0.0008985 | Direct |
| Integrin domains | 0.001083 | Inherited |
| ABC transporter ATPase domain-like | 0.001195 | Inherited |
| Nuclear receptor ligand-binding domain | 0.001634 | Inherited |
| Complement control module/SCR domain | 0.002233 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.002576 | Inherited |
| Intermediate filament protein, coiled coil region | 0.002647 | Inherited |
| Nuclear receptor | 0.003039 | Inherited |
| MHC antigen-recognition domain | 0.003539 | Inherited |
| Rhodopsin-like | 0.004119 | Inherited |
| Voltage-gated potassium channels | 0.005968 | Inherited |
| Cytochrome P450 | 0.007916 | Inherited |
| I set domains | 0.007999 | Inherited |
| Ngr ectodomain-like | 0.008423 | Inherited |
| Long-chain cytokines | 0.00979 | Inherited |
| Transforming growth factor (TGF)-beta | 0.01465 | Inherited |
| Tetramerization domain of potassium channels | 0.01497 | Inherited |
| Crystallins/Ca-binding development proteins | 0.01497 | Inherited |
| Aquaporin-like | 0.01497 | Inherited |
| Eukaryotic proteases | 0.01672 | Inherited |
| Transglutaminase core | 0.02294 | Inherited |
| Serpins | 0.0239 | Inherited |
| Integrin alpha N-terminal domain | 0.02405 | Inherited |
| EGF-type module | 0.02532 | Inherited |
| Glutathione peroxidase-like | 0.02586 | Inherited |
| ABC transporter transmembrane region | 0.02894 | Inherited |
| Transglutaminase N-terminal domain | 0.03569 | Inherited |
| Transglutaminase, two C-terminal domains | 0.03569 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.03569 | Inherited |
| Platelet-derived growth factor-like | 0.03569 | Inherited |
| Fibronectin type III | 0.04496 | Inherited |
| Laminin-type module | 0.04804 | Inherited |
| TSP-1 type 1 repeat | 0.04848 | Inherited |
| STAT | 0.05509 | Inherited |
| Transcription factor STAT-4 N-domain | 0.05509 | Inherited |
| SMAD domain | 0.05509 | Inherited |
| Erythroid transcription factor GATA-1 | 0.05509 | Inherited |
| STAT DNA-binding domain | 0.05509 | Inherited |
| SMAD MH1 domain | 0.05509 | Inherited |
| Globins | 0.05528 | Inherited |
| Spectrin repeat | 0.05843 | Inherited |
| DEATH domain, DD | 0.06086 | Inherited |
| Growth factor receptor domain | 0.06762 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.0846 | Inherited |
| Pancreatic lipase, N-terminal domain | 0.0846 | Inherited |
| L domain | 0.0846 | Inherited |
| Animal lipoxigenases | 0.0846 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.09242 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.114 | Inherited |
| C2 set domains | 0.114 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.1264 | Inherited |
| S100 proteins | 0.1264 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.1297 | Inherited |
| Notch domain | 0.1297 | Inherited |
| Lipoxigenase N-terminal domain | 0.1297 | Inherited |
| Hemopexin-like domain | 0.1307 | Inherited |
| Phosphate binding protein-like | 0.1311 | Inherited |
| Forkhead DNA-binding domain | 0.1621 | Inherited |
| MIR domain | 0.1623 | Inherited |
| Kringle modules | 0.1742 | Inherited |
| L-arabinose binding protein-like | 0.1924 | Inherited |
| C-type lectin domain | 0.1989 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2003 | Inherited |
| Exostosin | 0.2003 | Inherited |
| XPF/Rad1/Mus81 nuclease | 0.2003 | Inherited |
| Phenylalanine metabolism regulatory domain | 0.2003 | Inherited |
| DEATH effector domain, DED | 0.2003 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.2264 | Inherited |
| YWTD domain | 0.2264 | Inherited |
| Complement components | 0.2274 | Inherited |
| Penta-EF-hand proteins | 0.2274 | Inherited |
| Alpha-macroglobulin receptor domain | 0.2274 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.2274 | Inherited |
| EF-hand modules in multidomain proteins | 0.2307 | Inherited |
| Fibrinogen C-terminal domain-like | 0.2347 | Inherited |
| SH2 domain | 0.2415 | Inherited |
| Myosin rod fragments | 0.2764 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.3034 | Inherited |
| VWC domain | 0.3066 | Inherited |
| Pyrin domain, PYD | 0.3158 | Inherited |
| Proton glutamate symport protein | 0.3158 | Inherited |
| MMP N-terminal domain | 0.3223 | Inherited |
| Protein kinases, catalytic subunit | 0.3602 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3872 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3872 | Inherited |
| Caspase recruitment domain, CARD | 0.3916 | Inherited |
| Thyroglobulin type-1 domain | 0.3916 | Inherited |
| Defensin | 0.3977 | Inherited |
| V set domains (antibody variable domain-like) | 0.4092 | Inherited |
| Sir2 family of transcriptional regulators | 0.4298 | Inherited |
| Fibronectin type II module | 0.4605 | Inherited |
| Biotinyl/lipoyl-carrier proteins and domains | 0.5061 | Inherited |
| 28-residue LRR | 0.5091 | Inherited |
| Mitochondrial carrier | 0.5523 | Inherited |
| Annexin | 0.6061 | Inherited |
| T-box | 0.6061 | Inherited |
| Motor proteins | 0.6063 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.6205 | Inherited |
| Plexin repeat | 0.6289 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.6422 | Inherited |
| Calmodulin-like | 0.651 | Inherited |
| FAD-linked reductases, N-terminal domain | 0.6733 | Inherited |
| Ankyrin repeat | 0.6801 | Inherited |
| Cadherin | 0.8709 | Inherited |
| BCR-homology GTPase activation domain (BH-domain) | 0.8898 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.9686 | Inherited |
| SPRY domain | 0.9977 | Inherited |
| Homeodomain | 1 | Inherited |
| Canonical RBD | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Chitinase insertion domain | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| 4-helical cytokines | 0.00000003531 | DIRECT |
| Interleukin 8-like chemokines | 0.0000003089 | DIRECT |
| Voltage-gated potassium channels | 0.00000463 | DIRECT |
| Cystine-knot cytokines | 0.00002369 | DIRECT |
| Immunoglobulin | 0.00008908 | DIRECT |
| TNF-like | 0.0001461 | DIRECT |
| EGF/Laminin | 0.0006726 | DIRECT |
| Integrin domains | 0.0007399 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.0007399 | DIRECT |
| Cytokine | 0.0008446 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0009593 | DIRECT |
| Complement control module/SCR domain | 0.001337 | INHERITED FROM: blood platelet disease || degeneration of macula and posterior pole || hypersensitivity reaction type II disease || normocytic anemia || hematopoietic system disease || macular degeneration || Graves' disease || eye disease || hemolytic-uremic syndrome || glomerulonephritis |
| Intermediate filament protein, coiled coil region | 0.001642 | INHERITED FROM: palmoplantar keratosis || integumentary system disease |
| Riboflavin synthase domain-like | 0.001948 | INHERITED FROM: allergic rhinitis || nasal cavity disease || hypothyroidism || phagocyte bactericidal dysfunction || hypertension || lung disease || migraine |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.001948 | INHERITED FROM: allergic rhinitis || nasal cavity disease || hypothyroidism || phagocyte bactericidal dysfunction || hypertension || lung disease || migraine |
| Family A G protein-coupled receptor-like | 0.002328 | INHERITED FROM: bronchial disease || lower respiratory tract disease || asthma || arthritis || migraine |
| MHC antigen-recognition domain | 0.002339 | INHERITED FROM: neuromyelitis optica || bone inflammation disease || allergic rhinitis || alopecia || nasal cavity disease || vasculitis || liver disease || gastrointestinal system disease || Kawasaki disease || demyelinating disease || nose disease || vascular hemostatic disease || hypersensitivity reaction type II disease || intrahepatic cholestasis || hematopoietic system disease || connective tissue disease || hemorrhagic disease || pemphigus || spondylitis || lymph node disease || Graves' disease || multiple sclerosis || integumentary system disease || hypotrichosis || rheumatic fever || autoimmune disease of endocrine system || uveitis || sarcoidosis || thyroiditis || Behcet's disease || immune system disease || skin disease || neuromuscular junction disease |
| L domain-like | 0.002435 | INHERITED FROM: Bernard-Soulier syndrome || myopia || essential tremor |
| Cytochrome P450 | 0.003843 | INHERITED FROM: hyperandrogenism || bone remodeling disease || cardiovascular system disease || adrenal gland disease || sex differentiation disease |
| FnI-like domain | 0.004294 | INHERITED FROM: Ehlers-Danlos syndrome || cardiovascular system disease || lung disease || musculoskeletal system disease || arthritis || myocardial infarction |
| Metalloproteases ("zincins"), catalytic domain | 0.005461 | INHERITED FROM: female reproductive system disease || middle ear disease || Kawasaki disease || abdominal aortic aneurysm || atherosclerosis || mouth disease || artery disease || lymph node disease || cardiovascular system disease || arteriosclerotic cardiovascular disease || myopia || otitis media || refractive error || intrinsic cardiomyopathy || tooth disease |
| ABC transporter transmembrane region | 0.005562 | INHERITED FROM: brain disease || bronchiectasis || adrenoleukodystrophy || sclerosing cholangitis || biliary tract disease || intrahepatic cholestasis || diarrhea || hypersensitivity reaction disease || leukodystrophy || primary biliary cirrhosis |
| Trypsin-like serine proteases | 0.006007 | INHERITED FROM: degeneration of macula and posterior pole || hematopoietic system disease || inherited blood coagulation disease || macular degeneration || hereditary angioedema |
| gamma-Crystallin-like | 0.01236 | INHERITED FROM: sensory system disease || lens disease || eye and adnexa disease || eye disease || nervous system disease |
| Aquaporin-like | 0.01236 | INHERITED FROM: inner ear disease || female reproductive system disease || sensory system disease || placenta disease || bowel dysfunction || peripheral vertigo || vestibular disease || Meniere's disease || uterine disease |
| Serpins | 0.013 | INHERITED FROM: severe pre-eclampsia || vascular disease || chronic kidney disease || thrombophilia |
| vWA-like | 0.01565 | INHERITED FROM: bullous pemphigoid || dermatitis herpetiformis || thrombocytopenia |
| Snake toxin-like | 0.01596 | INHERITED FROM: abdominal aortic aneurysm || scleroderma || asthma |
| DEATH domain | 0.01681 | INHERITED FROM: bone inflammation disease || autoimmune lymphoproliferative syndrome || bone disease || spondyloarthropathy || familial Mediterranean fever || inflammatory bowel disease |
| Integrin alpha N-terminal domain | 0.01895 | INHERITED FROM: infertility |
| Fibronectin type III | 0.02395 | INHERITED FROM: demyelinating disease || acute kidney failure |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.03044 | INHERITED FROM: vascular disease || cardiovascular system disease |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.03044 | INHERITED FROM: vascular disease |
| Transglutaminase, two C-terminal domains | 0.03044 | INHERITED FROM: dermatitis herpetiformis || integumentary system disease || bullous skin disease || autoimmune disease of skin and connective tissue || skin disease |
| TSP-1 type 1 repeat | 0.03501 | INHERITED FROM: connective tissue disease || arthritis |
| Periplasmic binding protein-like II | 0.04354 | INHERITED FROM: temporal lobe epilepsy || lateral sclerosis || amyotrophic lateral sclerosis || nervous system disease |
| Spectrin repeat | 0.04597 | INHERITED FROM: muscular disease || vesiculobullous skin disease || muscle tissue disease |
| Globin-like | 0.04637 | INHERITED FROM: hematopoietic system disease || pneumonia || anemia |
| STAT | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
| Multidrug efflux transporter AcrB transmembrane domain | 0.04777 | INHERITED FROM: coronary artery disease |
| SMAD MH1 domain | 0.04777 | INHERITED FROM: nephritis || collagen disease || kidney disease || rheumatic disease || scleroderma || glomerulonephritis |
| Transcription factor STAT-4 N-domain | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
| C-type lectin-like | 0.05168 | INHERITED FROM: glomerulonephritis || bronchitis |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0673 | INHERITED FROM: gallbladder disease |
| Lipoxigenase | 0.07547 | INHERITED FROM: integumentary system disease || ichthyosis || tauopathy || Alzheimer's disease || skin disease |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.07782 | INHERITED FROM: pancreatitis || atherosclerosis || arteriosclerotic cardiovascular disease || ichthyosis || myocardial infarction |
| Periplasmic binding protein-like I | 0.07797 | INHERITED FROM: epilepsy || temporal lobe epilepsy || motor neuron disease || amyotrophic lateral sclerosis || nervous system disease |
| TIMP-like | 0.08213 | INHERITED FROM: bone inflammation disease || degeneration of macula and posterior pole || connective tissue disease || intracranial aneurysm || macular degeneration || periodontal disease || musculoskeletal system disease || arthritis || periodontitis || tooth disease || intracranial arterial disease |
| Growth factor receptor domain | 0.08435 | INHERITED FROM: autoimmune disease of blood || primary thrombocytopenia |
| Hemopexin-like domain | 0.1077 | INHERITED FROM: bronchiectasis || female reproductive system disease || bone inflammation disease || Kawasaki disease || reproductive system disease || abdominal aortic aneurysm || atherosclerosis || lower respiratory tract disease || mouth disease || artery disease || aortic disease || lymph node disease || arteriosclerotic cardiovascular disease || lymphatic system disease || myopia || Barrett's esophagus || scleroderma || lung disease || arthritis || refractive error || intrinsic cardiomyopathy || tooth disease |
| SEA domain | 0.1088 | INHERITED FROM: laryngeal disease |
| Cupredoxins | 0.1088 | INHERITED FROM: blood platelet disease || connective tissue disease || hemorrhagic disease |
| Bcl-2 inhibitors of programmed cell death | 0.1088 | INHERITED FROM: toxic encephalopathy || Graves' disease |
| Triple coiled coil domain of C-type lectins | 0.1175 | INHERITED FROM: allergic rhinitis || nasal cavity disease || nose disease || interstitial lung disease || lower respiratory tract disease || respiratory system disease || lung disease || upper respiratory tract disease || asthma |
| RuvA domain 2-like | 0.1175 | INHERITED FROM: hematopoietic system disease |
| Notch domain | 0.1175 | INHERITED FROM: hypersensitivity reaction type II disease || purpura || blood coagulation disease || hemorrhagic disease || hypersensitivity reaction disease || autoimmune disease of blood || immune system disease || primary thrombocytopenia |
| Calcium-dependent phosphotriesterase | 0.1175 | INHERITED FROM: celiac disease || lateral sclerosis || heart disease || motor neuron disease || coronary artery disease || amyotrophic lateral sclerosis || autoimmune disease of gastrointestinal tract |
| Phospholipase A2, PLA2 | 0.1175 | INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease |
| MAPEG domain-like | 0.1175 | INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease |
| p53-like transcription factors | 0.1306 | INHERITED FROM: colitis || intestinal disease || gastritis || Barrett's esophagus || lip disease || cheilitis || inflammatory bowel disease |
| CoA-dependent acyltransferases | 0.1435 | INHERITED FROM: autoimmune disease of urogenital tract || primary biliary cirrhosis |
| MIR domain | 0.1435 | INHERITED FROM: muscle tissue disease |
| Kringle-like | 0.1674 | INHERITED FROM: female reproductive system disease || cerebrovascular disease || vascular disease || liver disease || kidney disease || atherosclerosis || cholesteatoma || lower respiratory tract disease || meningitis || myositis || artery disease || arteriosclerosis || urinary system disease || salivary gland disease || carotid stenosis || dermatomyositis || arteriosclerotic cardiovascular disease || myopia || pulmonary fibrosis || periodontal disease || endometriosis || refractive error || leukodystrophy || myocardial infarction || tooth disease || immune system disease |
| SH2 domain | 0.1746 | INHERITED FROM: bone marrow disease |
| ACT-like | 0.1827 | INHERITED FROM: brain disease |
| PRTase-like | 0.1827 | INHERITED FROM: bone inflammation disease || arthritis || gout |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.1827 | INHERITED FROM: brain disease |
| Restriction endonuclease-like | 0.1827 | INHERITED FROM: hematopoietic system disease |
| Fibrinogen C-terminal domain-like | 0.1947 | INHERITED FROM: congenital afibrinogenemia |
| Blood coagulation inhibitor (disintegrin) | 0.1958 | INHERITED FROM: atherosclerosis || artery disease || arteriosclerotic cardiovascular disease |
| YWTD domain | 0.1958 | INHERITED FROM: vascular disease || artery disease || cardiovascular system disease || tauopathy || Alzheimer's disease |
| Class II aaRS and biotin synthetases | 0.2032 | INHERITED FROM: neuromuscular disease || Charcot-Marie-Tooth disease || neuropathy |
| Alpha-macroglobulin receptor domain | 0.2036 | INHERITED FROM: demyelinating disease || mouth disease || psoriasis || multiple sclerosis || periodontal disease || proteinuria || periodontitis || tooth disease |
| Inhibitor of apoptosis (IAP) repeat | 0.2036 | INHERITED FROM: demyelinating disease || multiple sclerosis |
| Thioredoxin-like | 0.2105 | INHERITED FROM: Pick's disease || congenital hemolytic anemia || esophageal disease |
| Protein kinase-like (PK-like) | 0.2194 | INHERITED FROM: ataxia telangiectasia || synostosis |
| RNI-like | 0.2673 | INHERITED FROM: bronchiolitis || bone inflammation disease || panuveitis || allergic rhinitis || Crohn's disease || nasal cavity disease || nose disease || uveal disease || uveitis || periodontal disease || inflammatory bowel disease || sarcoidosis || periodontitis |
| Terpenoid cyclases/Protein prenyltransferases | 0.272 | INHERITED FROM: mouth disease || psoriasis || periodontal disease || proteinuria || periodontitis || tooth disease |
| PGBD-like | 0.2789 | INHERITED FROM: bronchiectasis || female reproductive system disease || bone inflammation disease || gastrointestinal system disease || Kawasaki disease || reproductive system disease || abdominal aortic aneurysm || atherosclerosis || lower respiratory tract disease || mouth disease || myositis || artery disease || aortic disease || dermatomyositis || lymph node disease || respiratory system disease || arteriosclerotic cardiovascular disease || myopia || Barrett's esophagus || scleroderma || lung disease || musculoskeletal system disease || arthritis || refractive error || intrinsic cardiomyopathy || tooth disease |
| Proton glutamate symport protein | 0.2859 | INHERITED FROM: demyelinating disease || multiple sclerosis |
| Nicotinic receptor ligand binding domain-like | 0.3175 | INHERITED FROM: brain disease || early myoclonic encephalopathy || Lewy body dementia || frontal lobe epilepsy || nervous system disease |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3175 | INHERITED FROM: brain disease || early myoclonic encephalopathy || Lewy body dementia || frontal lobe epilepsy || nervous system disease |
| Thyroglobulin type-1 domain | 0.3394 | INHERITED FROM: hypothyroidism || thyroid gland disease |
| Defensin-like | 0.3564 | INHERITED FROM: atopic dermatitis || gastritis || dermatitis || periodontal disease || periodontitis || tooth disease |
| Myosin rod fragments | 0.448 | INHERITED FROM: dilated cardiomyopathy |
| Nudix | 0.4614 | INHERITED FROM: lateral sclerosis || motor neuron disease || amyotrophic lateral sclerosis |
| Single hybrid motif | 0.4614 | INHERITED FROM: autoimmune disease of urogenital tract || liver cirrhosis || primary biliary cirrhosis |
| Cysteine proteinases | 0.4903 | INHERITED FROM: dermatitis herpetiformis || autoimmune disease of skin and connective tissue |
| Mitochondrial carrier | 0.4943 | INHERITED FROM: peripheral nervous system disease || diabetic neuropathy |
| MFS general substrate transporter | 0.5067 | INHERITED FROM: hypoglycemia || lipodystrophy || gout |
| Ankyrin repeat | 0.5444 | INHERITED FROM: primary thrombocytopenia |
| Annexin | 0.5501 | INHERITED FROM: osteonecrosis || ischemic bone disease |
| Plexin repeat | 0.5551 | INHERITED FROM: bullous pemphigoid || dermatitis herpetiformis || bullous skin disease || autoimmune disease of skin and connective tissue |
| E set domains | 0.5747 | INHERITED FROM: dermatitis herpetiformis || autoimmune disease of skin and connective tissue |
| EF-hand | 0.6164 | INHERITED FROM: Duchenne muscular dystrophy |
| Cadherin-like | 0.6401 | INHERITED FROM: pemphigus |
| GST C-terminal domain-like | 0.6474 | INHERITED FROM: hemoglobinopathy || normocytic anemia || Barrett's esophagus || congenital hemolytic anemia |
| HSP20-like chaperones | 0.668 | INHERITED FROM: peripheral nervous system disease |
| Calponin-homology domain, CH-domain | 0.8605 | INHERITED FROM: muscle tissue disease |
| Nucleotide-diphospho-sugar transferases | 0.9398 | INHERITED FROM: exostosis || hereditary multiple exostoses |
| RNA-binding domain, RBD | 0.9903 | INHERITED FROM: transient cerebral ischemia || myopathy of extraocular muscle |
| GTPase activation domain, GAP | 0.9978 | INHERITED FROM: bone marrow disease |
| HLH, helix-loop-helix DNA-binding domain | 0.9988 | INHERITED FROM: dysostosis |
| SET domain | 1 | INHERITED FROM: phagocyte bactericidal dysfunction |
| Homeodomain-like | 1 | INHERITED FROM: hypopituitarism || pituitary gland disease |
| ARM repeat | 1 | INHERITED FROM: Peutz-Jeghers syndrome || ataxia telangiectasia || hereditary ataxia |
| PH domain-like | 1 | INHERITED FROM: centronuclear myopathy |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Chitinase insertion domain | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| PA domain | 0 | Direct |
| BPTI-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Hairpin loop containing domain-like | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| GLA-domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| Synuclein | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Flavoproteins | 0 | Direct |
| 4-helical cytokines | 0.00000003531 | Direct |
| Interleukin 8-like chemokines | 0.0000003089 | Direct |
| Voltage-gated potassium channels | 0.00000463 | Direct |
| Cystine-knot cytokines | 0.00002369 | Direct |
| Immunoglobulin | 0.00008908 | Direct |
| TNF-like | 0.0001461 | Direct |
| EGF/Laminin | 0.0006726 | Direct |
| Integrin domains | 0.0007399 | Direct |
| Toll/Interleukin receptor TIR domain | 0.0007399 | Direct |
| Cytokine | 0.0008446 | Direct |
| Nuclear receptor ligand-binding domain | 0.0009593 | Direct |
| Complement control module/SCR domain | 0.001337 | Inherited |
| Intermediate filament protein, coiled coil region | 0.001642 | Inherited |
| Riboflavin synthase domain-like | 0.001948 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.001948 | Inherited |
| Family A G protein-coupled receptor-like | 0.002328 | Inherited |
| MHC antigen-recognition domain | 0.002339 | Inherited |
| L domain-like | 0.002435 | Inherited |
| Cytochrome P450 | 0.003843 | Inherited |
| FnI-like domain | 0.004294 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.005461 | Inherited |
| ABC transporter transmembrane region | 0.005562 | Inherited |
| Trypsin-like serine proteases | 0.006007 | Inherited |
| gamma-Crystallin-like | 0.01236 | Inherited |
| Aquaporin-like | 0.01236 | Inherited |
| Serpins | 0.013 | Inherited |
| vWA-like | 0.01565 | Inherited |
| Snake toxin-like | 0.01596 | Inherited |
| DEATH domain | 0.01681 | Inherited |
| Integrin alpha N-terminal domain | 0.01895 | Inherited |
| Fibronectin type III | 0.02395 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.03044 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.03044 | Inherited |
| Transglutaminase, two C-terminal domains | 0.03044 | Inherited |
| TSP-1 type 1 repeat | 0.03501 | Inherited |
| Periplasmic binding protein-like II | 0.04354 | Inherited |
| Spectrin repeat | 0.04597 | Inherited |
| Globin-like | 0.04637 | Inherited |
| STAT | 0.04777 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.04777 | Inherited |
| SMAD MH1 domain | 0.04777 | Inherited |
| Transcription factor STAT-4 N-domain | 0.04777 | Inherited |
| C-type lectin-like | 0.05168 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0673 | Inherited |
| Lipoxigenase | 0.07547 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.07782 | Inherited |
| Periplasmic binding protein-like I | 0.07797 | Inherited |
| TIMP-like | 0.08213 | Inherited |
| Growth factor receptor domain | 0.08435 | Inherited |
| Hemopexin-like domain | 0.1077 | Inherited |
| SEA domain | 0.1088 | Inherited |
| Cupredoxins | 0.1088 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.1088 | Inherited |
| Triple coiled coil domain of C-type lectins | 0.1175 | Inherited |
| RuvA domain 2-like | 0.1175 | Inherited |
| Notch domain | 0.1175 | Inherited |
| Calcium-dependent phosphotriesterase | 0.1175 | Inherited |
| Phospholipase A2, PLA2 | 0.1175 | Inherited |
| MAPEG domain-like | 0.1175 | Inherited |
| p53-like transcription factors | 0.1306 | Inherited |
| CoA-dependent acyltransferases | 0.1435 | Inherited |
| MIR domain | 0.1435 | Inherited |
| Kringle-like | 0.1674 | Inherited |
| SH2 domain | 0.1746 | Inherited |
| ACT-like | 0.1827 | Inherited |
| PRTase-like | 0.1827 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.1827 | Inherited |
| Restriction endonuclease-like | 0.1827 | Inherited |
| Fibrinogen C-terminal domain-like | 0.1947 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.1958 | Inherited |
| YWTD domain | 0.1958 | Inherited |
| Class II aaRS and biotin synthetases | 0.2032 | Inherited |
| Alpha-macroglobulin receptor domain | 0.2036 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.2036 | Inherited |
| Thioredoxin-like | 0.2105 | Inherited |
| Protein kinase-like (PK-like) | 0.2194 | Inherited |
| RNI-like | 0.2673 | Inherited |
| Terpenoid cyclases/Protein prenyltransferases | 0.272 | Inherited |
| PGBD-like | 0.2789 | Inherited |
| Proton glutamate symport protein | 0.2859 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3175 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3175 | Inherited |
| Thyroglobulin type-1 domain | 0.3394 | Inherited |
| Defensin-like | 0.3564 | Inherited |
| Myosin rod fragments | 0.448 | Inherited |
| Nudix | 0.4614 | Inherited |
| Single hybrid motif | 0.4614 | Inherited |
| Cysteine proteinases | 0.4903 | Inherited |
| Mitochondrial carrier | 0.4943 | Inherited |
| MFS general substrate transporter | 0.5067 | Inherited |
| Ankyrin repeat | 0.5444 | Inherited |
| Annexin | 0.5501 | Inherited |
| Plexin repeat | 0.5551 | Inherited |
| E set domains | 0.5747 | Inherited |
| EF-hand | 0.6164 | Inherited |
| Cadherin-like | 0.6401 | Inherited |
| GST C-terminal domain-like | 0.6474 | Inherited |
| HSP20-like chaperones | 0.668 | Inherited |
| Calponin-homology domain, CH-domain | 0.8605 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.9398 | Inherited |
| RNA-binding domain, RBD | 0.9903 | Inherited |
| GTPase activation domain, GAP | 0.9978 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.9988 | Inherited |
| SET domain | 1 | Inherited |
| Homeodomain-like | 1 | Inherited |
| ARM repeat | 1 | Inherited |
| PH domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
49265,56112
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | DIRECT |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | DIRECT |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | DIRECT |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | DIRECT |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | DIRECT |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
102712,-7
102712 - JAB1/MPN domain
-7 - CATH | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.0003557 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.0007682 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.001479 | INHERITED FROM: demyelinating disease || multiple sclerosis |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.002575 | INHERITED FROM: bullous pemphigoid || vesiculobullous skin disease || blood coagulation disease || junctional epidermolysis bullosa || autoimmune disease of blood || primary thrombocytopenia |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.004201 | INHERITED FROM: demyelinating disease || bullous pemphigoid || synostosis || multiple sclerosis || craniosynostosis || acute kidney failure || musculoskeletal system disease || immune system disease |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.004784 | INHERITED FROM: gallbladder disease |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.005562 | INHERITED FROM: brain disease || bronchiectasis || adrenoleukodystrophy || sclerosing cholangitis || biliary tract disease || intrahepatic cholestasis || diarrhea || hypersensitivity reaction disease || leukodystrophy || primary biliary cirrhosis |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.006278 | INHERITED FROM: infertility |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.006278 | INHERITED FROM: infertility |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.01416 | INHERITED FROM: vascular disease || artery disease || tauopathy || Alzheimer's disease |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0193 | INHERITED FROM: phagocyte bactericidal dysfunction || primary immunodeficiency disease |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.0193 | INHERITED FROM: female reproductive system disease || vascular disease || liver disease || hypersensitivity reaction type II disease || atherosclerosis || lower respiratory tract disease || artery disease || blood coagulation disease || cardiovascular system disease || arteriosclerotic cardiovascular disease || cerebral degeneration || central nervous system disease || lung disease || periodontal disease || endometriosis || leukodystrophy || myocardial infarction || tooth disease |
54001,49309
54001 - Cysteine proteinases
49309 - Transglutaminase, two C-terminal domains | 0.03044 | INHERITED FROM: dermatitis herpetiformis || integumentary system disease || bullous skin disease || autoimmune disease of skin and connective tissue || skin disease |
81296,54001
81296 - E set domains
54001 - Cysteine proteinases | 0.03044 | INHERITED FROM: dermatitis herpetiformis || integumentary system disease || bullous skin disease || autoimmune disease of skin and connective tissue || skin disease |
49309,49309
49309 - Transglutaminase, two C-terminal domains
49309 - Transglutaminase, two C-terminal domains | 0.03044 | INHERITED FROM: dermatitis herpetiformis || integumentary system disease || bullous skin disease || autoimmune disease of skin and connective tissue || skin disease |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.03044 | INHERITED FROM: integumentary system disease |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.03044 | INHERITED FROM: vascular disease |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.04597 | INHERITED FROM: purpura || blood coagulation disease || hemorrhagic disease || autoimmune disease of blood || primary thrombocytopenia |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.04777 | INHERITED FROM: heart disease || cardiovascular system disease || cardiomyopathy || intrinsic cardiomyopathy |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.04777 | INHERITED FROM: lower respiratory tract disease || respiratory system disease || immune system disease || skin disease |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.04777 | INHERITED FROM: palmoplantar keratosis || skin disease |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.04777 | INHERITED FROM: muscular disease || muscular dystrophy || muscle tissue disease |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.06011 | INHERITED FROM: purpura || autoimmune disease of blood || primary thrombocytopenia |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.06011 | INHERITED FROM: muscular disease || muscle tissue disease |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07547 | INHERITED FROM: neuropathy |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.07547 | INHERITED FROM: integumentary system disease || ichthyosis || tauopathy || Alzheimer's disease || skin disease |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.07547 | INHERITED FROM: neuropathy |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.08063 | INHERITED FROM: blood platelet disease || thrombocytosis || severe combined immunodeficiency |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.08327 | INHERITED FROM: bone development disease |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1175 | INHERITED FROM: tauopathy || Alzheimer's disease |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.1175 | INHERITED FROM: allergic rhinitis || nasal cavity disease || nose disease || interstitial lung disease || lower respiratory tract disease || respiratory system disease || lung disease || upper respiratory tract disease || asthma |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.1175 | INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease || tauopathy || Alzheimer's disease |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.1175 | INHERITED FROM: pancreatitis || atherosclerosis || arteriosclerosis || pancreas disease || heart disease || arteriosclerotic cardiovascular disease || coronary artery disease || endocrine system disease || myocardial infarction |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.1947 | INHERITED FROM: retinitis || retinitis pigmentosa || retinal degeneration |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.1958 | INHERITED FROM: atherosclerosis || artery disease || arteriosclerotic cardiovascular disease |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.2383 | INHERITED FROM: muscular dystrophy || Duchenne muscular dystrophy |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.2383 | INHERITED FROM: kidney disease || chronic kidney disease || urinary system disease || glomerulonephritis |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.2789 | INHERITED FROM: bronchiectasis || female reproductive system disease || bone inflammation disease || gastrointestinal system disease || Kawasaki disease || reproductive system disease || abdominal aortic aneurysm || atherosclerosis || lower respiratory tract disease || mouth disease || myositis || artery disease || aortic disease || dermatomyositis || lymph node disease || respiratory system disease || arteriosclerotic cardiovascular disease || myopia || Barrett's esophagus || scleroderma || lung disease || musculoskeletal system disease || arthritis || refractive error || intrinsic cardiomyopathy || tooth disease |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.3175 | INHERITED FROM: brain disease || early myoclonic encephalopathy || Lewy body dementia || frontal lobe epilepsy || nervous system disease |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.3394 | INHERITED FROM: female reproductive system disease || gastrointestinal system disease || Kawasaki disease || reproductive system disease || atherosclerosis || mouth disease || lymph node disease || arteriosclerotic cardiovascular disease || lymphatic system disease || dilated cardiomyopathy || Barrett's esophagus || lung disease || tooth disease |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4032 | INHERITED FROM: transient cerebral ischemia |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.412 | INHERITED FROM: colitis |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.4132 | INHERITED FROM: ataxia telangiectasia || peripheral vascular disease || hereditary ataxia || autosomal recessive cerebellar ataxia || telangiectasis |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.448 | INHERITED FROM: obstructive lung disease || hemoglobinopathy || normocytic anemia || Barrett's esophagus || congenital hemolytic anemia |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.4507 | INHERITED FROM: cardiomyopathy || acute kidney failure || intrinsic cardiomyopathy |
50729,50729
50729 - PH domain-like
50729 - PH domain-like | 0.5544 | INHERITED FROM: gonadal disease || hyperandrogenism || sex differentiation disease |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.7911 | INHERITED FROM: pemphigus || hypotrichosis |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
49265,56112
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | Direct |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | Direct |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | Direct |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | Direct |
57603,82895
57603 - FnI-like domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | Direct |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
102712,-7
102712 - JAB1/MPN domain
-7 - CATH | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.0003557 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.0007682 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.001479 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.002575 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.004201 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.004784 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.005562 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.006278 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.006278 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.01416 | Inherited |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0193 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.0193 | Inherited |
54001,49309
54001 - Cysteine proteinases
49309 - Transglutaminase, two C-terminal domains | 0.03044 | Inherited |
81296,54001
81296 - E set domains
54001 - Cysteine proteinases | 0.03044 | Inherited |
49309,49309
49309 - Transglutaminase, two C-terminal domains
49309 - Transglutaminase, two C-terminal domains | 0.03044 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.03044 | Inherited |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.03044 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.04597 | Inherited |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.04777 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.04777 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.04777 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04777 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.04777 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.04777 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.04777 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.06011 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.06011 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07547 | Inherited |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.07547 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.07547 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.08063 | Inherited |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.08327 | Inherited |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1175 | Inherited |
57944,56436
57944 - Triple coiled coil domain of C-type lectins
56436 - C-type lectin-like | 0.1175 | Inherited |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.1175 | Inherited |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.1175 | Inherited |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.1947 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.1958 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.2383 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.2383 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.2789 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.3175 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.3394 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4032 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.412 | Inherited |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.4132 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.448 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.4507 | Inherited |
50729,50729
50729 - PH domain-like
50729 - PH domain-like | 0.5544 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.7911 | Inherited |
(show details)
Supra-domains annotated to this DO term (Not in SPDO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
53300,53300,53300
53300 - vWA-like
53300 - vWA-like
53300 - vWA-like | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.0001831 | DIRECT |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.006278 | INHERITED FROM: infertility |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.01416 | INHERITED FROM: infertility |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01512 | INHERITED FROM: purpura || vesiculobullous skin disease || blood coagulation disease || junctional epidermolysis bullosa || autoimmune disease of blood || primary thrombocytopenia |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0193 | INHERITED FROM: hypersensitivity reaction type II disease || purpura || blood coagulation disease || hemorrhagic disease || autoimmune disease of blood || primary thrombocytopenia |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.02103 | INHERITED FROM: vascular disease || artery disease || tauopathy || Alzheimer's disease |
81296,54001,49309
81296 - E set domains
54001 - Cysteine proteinases
49309 - Transglutaminase, two C-terminal domains | 0.03044 | INHERITED FROM: dermatitis herpetiformis || integumentary system disease || bullous skin disease || autoimmune disease of skin and connective tissue || skin disease |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.03044 | INHERITED FROM: vascular disease |
54001,49309,49309
54001 - Cysteine proteinases
49309 - Transglutaminase, two C-terminal domains
49309 - Transglutaminase, two C-terminal domains | 0.03044 | INHERITED FROM: dermatitis herpetiformis || integumentary system disease || bullous skin disease || autoimmune disease of skin and connective tissue || skin disease |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0.03129 | INHERITED FROM: bone resorption disease |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.03877 | INHERITED FROM: muscular disease || muscle tissue disease |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04637 | INHERITED FROM: cerebrovascular disease |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04777 | INHERITED FROM: colitis || nephritis || intestinal disease || lower respiratory tract disease || respiratory system disease || inflammatory bowel disease || asthma || glomerulonephritis || Sjogren's syndrome |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.06011 | INHERITED FROM: idiopathic interstitial pneumonia |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07547 | INHERITED FROM: neuropathy |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1113 | INHERITED FROM: purpura || blood coagulation disease || hemorrhagic disease || autoimmune disease of blood || primary thrombocytopenia |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1143 | INHERITED FROM: synostosis || craniosynostosis || dysostosis |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.1827 | INHERITED FROM: tauopathy || Alzheimer's disease |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0.1827 | INHERITED FROM: lower respiratory tract disease || respiratory system disease || peripheral nervous system disease || neuropathy |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1827 | INHERITED FROM: tauopathy || Alzheimer's disease |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3729 | INHERITED FROM: cardiomyopathy || acute kidney failure || intrinsic cardiomyopathy |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.4943 | INHERITED FROM: female reproductive system disease || gastrointestinal system disease || Kawasaki disease || reproductive system disease || atherosclerosis || lower respiratory tract disease || mouth disease || lymph node disease || arteriosclerotic cardiovascular disease || dilated cardiomyopathy || Barrett's esophagus || lung disease || intrinsic cardiomyopathy || tooth disease |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.7911 | INHERITED FROM: pemphigus || hypotrichosis |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
53300,53300,53300
53300 - vWA-like
53300 - vWA-like
53300 - vWA-like | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.0001831 | Direct |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.006278 | Inherited |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.01416 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01512 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0193 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.02103 | Inherited |
81296,54001,49309
81296 - E set domains
54001 - Cysteine proteinases
49309 - Transglutaminase, two C-terminal domains | 0.03044 | Inherited |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.03044 | Inherited |
54001,49309,49309
54001 - Cysteine proteinases
49309 - Transglutaminase, two C-terminal domains
49309 - Transglutaminase, two C-terminal domains | 0.03044 | Inherited |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0.03129 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.03877 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04637 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.04777 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04777 | Inherited |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.06011 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.07547 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1113 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1143 | Inherited |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.1827 | Inherited |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0.1827 | Inherited |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1827 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3729 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.4943 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.7911 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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