|
|
Enzyme Commission (EC): Oxidoreductases
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| Thioredoxin-like | 0 | DIRECT |
| Bacterial luciferase-like | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| Nqo1 middle domain-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Dihydropteroate synthetase-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| Frataxin/Nqo15-like | 0 | DIRECT |
| "Helical backbone" metal receptor | 0 | DIRECT |
| HydA/Nqo6-like | 0 | DIRECT |
| Ribbon-helix-helix | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Methylamine dehydrogenase, L chain | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| Prismane protein-like | 0 | DIRECT |
| Multiheme cytochromes | 0 | DIRECT |
| HydB/Nqo4-like | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Heme oxygenase-like | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | DIRECT |
| Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
| Fe-only hydrogenase | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| Copper amine oxidase, domain N | 0 | DIRECT |
| Clavaminate synthase-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| N-terminal domain of bifunctional PutA protein | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | DIRECT |
| Nqo5-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Nqo1C-terminal domain-like | 0 | DIRECT |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | DIRECT |
| LigB-like | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| FMN-dependent nitroreductase-like | 0 | DIRECT |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Globin-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
| YebC-like | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | DIRECT |
| PFL-like glycyl radical enzymes | 0 | DIRECT |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| Nucleotide-binding domain | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| Peptide methionine sulfoxide reductase | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Dihydrofolate reductase-like | 0 | DIRECT |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | DIRECT |
| alpha-helical ferredoxin | 0 | DIRECT |
| Cytochrome c oxidase subunit III-like | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Hemocyanin, N-terminal domain | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| Cytochrome c oxidase subunit I-like | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| Aromatic compound dioxygenase | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | DIRECT |
| Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
| Respiratory nitrate reductase 1 gamma chain | 0 | DIRECT |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| DinB/YfiT-like putative metalloenzymes | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Superoxide reductase-like | 0 | DIRECT |
| Calponin-homology domain, CH-domain | 0.000000000000006503 | DIRECT |
| PHM/PNGase F | 0.00000000000002171 | DIRECT |
| Nqo1 FMN-binding domain-like | 0.000000000001162 | DIRECT |
| Serine metabolism enzymes domain | 0.00000000009387 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0.0000000001378 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.0000000007957 | DIRECT |
| Rubredoxin-like | 0.00000006026 | DIRECT |
| C-type lectin-like | 0.00000009109 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0.0000001026 | DIRECT |
| SRCR-like | 0.0000002305 | DIRECT |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.000001337 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.000003303 | DIRECT |
| ParB/Sulfiredoxin | 0.000008645 | DIRECT |
| NTF2-like | 0.00003039 | DIRECT |
| EGF/Laminin | 0.00005826 | DIRECT |
| Dimeric alpha+beta barrel | 0.001178 | INHERITED FROM: Dye decolorizing peroxidase || Acting on a peroxide as acceptor || Miscellaneous || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Peroxidases || Peroxidase || Heme oxygenase (staphylobilin-producing) || Heme oxygenase (biliverdin-producing) || Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated |
| Lipocalins | 0.001839 | INHERITED FROM: With a quinone or similar compound as acceptor || Reducing C-O-C group as acceptor |
| TK C-terminal domain-like | 0.00197 | INHERITED FROM: With an iron-sulfur protein as acceptor || Acting on the aldehyde or oxo group of donors || Pyruvate dehydrogenase (acetyl-transferring) || With a disulfide as acceptor |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.002387 | INHERITED FROM: With other acceptors || Acting on other nitrogenous compounds as donors || With a cytochrome as acceptor || Nitrite reductase (NO-forming) |
| Galactose oxidase, central domain | 0.002727 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || With oxygen as acceptor || Aldehyde oxidase |
| SCOP hierarchy in SUPERFAMILY | 0.005219 | INHERITED FROM: With a disulfide as acceptor || Ribonucleoside-diphosphate reductase || Peroxidases || Acting on CH or CH(2) groups || Photosystem I |
| FnI-like domain | 0.005838 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| SCP-like | 0.008239 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || (3R)-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors |
| ACP-like | 0.0103 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || L-2-aminoadipate reductase || Acting on the aldehyde or oxo group of donors || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || L-aminoadipate-semialdehyde dehydrogenase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor |
| Nitrous oxide reductase, N-terminal domain | 0.01656 | INHERITED FROM: Nitrous-oxide reductase || Acting on other nitrogenous compounds as donors || With a cytochrome as acceptor |
| HSP20-like chaperones | 0.02137 | INHERITED FROM: With a heme protein as acceptor || Cytochrome-b5 reductase || Acting on NADH or NADPH |
| HIT/MYND zinc finger-like | 0.06322 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Hypoxia-inducible factor-proline dioxygenase || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Electron transport accessory proteins | 0.1086 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrofolate reductase || Acting on the CH-NH group of donors |
| FYVE/PHD zinc finger | 0.2985 | INHERITED FROM: [Histone H3]-dimethyl-L-lysine(36) demethylase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| NHL repeat | 0.3172 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With reduced ascorbate as one donor, and incorporation of one atom of oxygen || Peptidylglycine monooxygenase |
| TPR-like | 0.3981 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Peptide-aspartate beta-dioxygenase || Procollagen-proline 4-dioxygenase || Procollagen-proline 3-dioxygenase |
| HMA, heavy metal-associated domain | 0.4141 | INHERITED FROM: Oxidizing metal ions || With NAD(+) or NADP(+) as acceptor || Mercury(II) reductase |
| ARM repeat | 0.4393 | INHERITED FROM: Deoxyhypusine monooxygenase || Miscellaneous || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With other acceptors || Epoxyqueuosine reductase |
| Complement control module/SCR domain | 0.4453 | INHERITED FROM: Iodide peroxidase || Acting on a peroxide as acceptor || Peroxidases |
| Chorismate mutase II | 0.5385 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Prephenate dehydrogenase || Acting on the CH-CH group of donors |
| SMAD/FHA domain | 0.5524 | INHERITED FROM: Zeaxanthin epoxidase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
| Tudor/PWWP/MBT | 0.716 | INHERITED FROM: Delta(14)-sterol reductase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors |
| RNI-like | 0.8363 | INHERITED FROM: [Histone H3]-dimethyl-L-lysine(36) demethylase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| FabD/lysophospholipase-like | 0.9164 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Acting on the CH-CH group of donors |
| Calcium-dependent phosphotriesterase | 0.9744 | INHERITED FROM: With reduced ascorbate as one donor, and incorporation of one atom of oxygen || Peptidylglycine monooxygenase |
| ACT-like | 0.9792 | INHERITED FROM: 2-oxoglutarate reductase || With NAD(+) or NADP(+) as acceptor || Prephenate dehydrogenase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Homoserine dehydrogenase || With reduced pteridine as one donor, and incorporation of one atom of oxygen || Phosphoglycerate dehydrogenase |
| EPT/RTPC-like | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Shikimate dehydrogenase |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| Radical SAM enzymes | 1 | INHERITED FROM: With other, known acceptors || [Formate-C-acetyltransferase]-activating enzyme || With other, known, acceptors || Catalyzing the reaction X-H + Y-H = 'X-Y' || Coproporphyrinogen dehydrogenase |
| EF-hand | 1 | INHERITED FROM: With oxygen as acceptor || NAD(P)H oxidase (H(2)O(2)-forming) || Glycerol-3-phosphate dehydrogenase || Acting on NADH or NADPH || NADH:ubiquinone reductase (non-electrogenic) || With H(2)O(2) as acceptor, one oxygen atom of which is incorporated into the product || With a quinone or similar compound as acceptor || Plant seed peroxygenase |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Glutamate synthase (NADPH) || Glutamate synthase (NADH) || With an iron-sulfur protein as acceptor || Acting on the CH-NH(2) group of donors |
| L domain-like | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Chloride peroxidase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With NADH or NADPH as one donor, and incorporation of one atom of oxygen || F-actin monooxygenase |
| Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With oxygen as acceptor || With a flavin as acceptor || Acting on the CH-NH group of donors |
| ClpP/crotonase | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 3-hydroxyacyl-CoA dehydrogenase || Long-chain-3-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors |
| all-alpha NTP pyrophosphatases | 1 | INHERITED FROM: Histidinol dehydrogenase |
| ThiG-like | 1 | INHERITED FROM: Glycine oxidase |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | INHERITED FROM: Carnitine 3-dehydrogenase || Enoyl-[acyl-carrier-protein] reductase (NADH) || (3R)-hydroxyacyl-CoA dehydrogenase |
| Adenine nucleotide alpha hydrolases-like | 1 | INHERITED FROM: With a disulfide as acceptor || Phosphoadenylyl-sulfate reductase (thioredoxin) || Acting on a sulfur group of donors |
| Thiolase-like | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Homing endonucleases | 1 | INHERITED FROM: With a disulfide as acceptor || Ribonucleoside-diphosphate reductase || Acting on CH or CH(2) groups |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: L-2-aminoadipate reductase || Oxoglutarate dehydrogenase (succinyl-transferring) || Acting on the aldehyde or oxo group of donors || L-aminoadipate-semialdehyde dehydrogenase || With a disulfide as acceptor |
| E set domains | 1 | INHERITED FROM: With another compound as one donor, and incorporation of one atom of oxygen || Nitrate reductase (NADPH) || Tyrosinase || With oxygen as acceptor || With oxygen as acceptor || Sulfite oxidase || Acting on other nitrogenous compounds as donors || Aldehyde oxidase || Nitrate reductase (NADH) || With NAD(+) or NADP(+) as acceptor |
| 4'-phosphopantetheinyl transferase | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| FMT C-terminal domain-like | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Procollagen-lysine 5-dioxygenase |
| Ubiquitin-like | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Very-long-chain enoyl-CoA reductase |
| PLP-dependent transferases | 1 | INHERITED FROM: With a disulfide as acceptor || Acting on the CH-NH(2) group of donors |
| Aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Enolase C-terminal domain-like | 1 | INHERITED FROM: Acting on CH or CH(2) groups || With an iron-sulfur protein as acceptor || (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) |
| Folate-binding domain | 1 | INHERITED FROM: With oxygen as acceptor || With a flavin as acceptor || Acting on the CH-NH group of donors |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Firefly luciferase || L-2-aminoadipate reductase || With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase || L-aminoadipate-semialdehyde dehydrogenase |
| GST C-terminal domain-like | 1 | INHERITED FROM: Acting on phosphorus or arsenic in donors || With a quinone or similar compound as acceptor || Methylarsonate reductase || With disulfide as acceptor || Acting on a sulfur group of donors |
| Immunoglobulin | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| Cytidine deaminase-like | 1 | INHERITED FROM: 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| Formyltransferase | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
| PDZ domain-like | 1 | INHERITED FROM: With NADH or NADPH as one donor, and incorporation of one atom of oxygen || Nitric-oxide synthase (NADPH) |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Catalase |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrofolate reductase || Acting on the CH-NH group of donors |
| HD-domain/PDEase-like | 1 | INHERITED FROM: Miscellaneous || Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Acting on iron-sulfur proteins as donors || Ferredoxin:protochlorophyllide reductase (ATP-dependent) || With an iron-sulfur protein as acceptor || Thymine dioxygenase || With dinitrogen as acceptor || Shikimate dehydrogenase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase (NAD(P)(+)) || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| Hedgehog/intein (Hint) domain | 1 | INHERITED FROM: With a disulfide as acceptor || Ribonucleoside-diphosphate reductase || Acting on CH or CH(2) groups |
| Cysteine-rich domain | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Protein-disulfide reductase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Acting on the CH-CH group of donors |
| Rhodanese/Cell cycle control phosphatase | 1 | INHERITED FROM: Acting on phosphorus or arsenic in donors || Arsenate reductase (glutaredoxin) || With disulfide as acceptor |
| Carbamate kinase-like | 1 | INHERITED FROM: Homoserine dehydrogenase || Glutamate-5-semialdehyde dehydrogenase |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Bromide peroxidase |
| Metallo-hydrolase/oxidoreductase | 1 | INHERITED FROM: With another compound as one donor, and incorporation of one atom of oxygen || Persulfide dioxygenase || CMP-N-acetylneuraminate monooxygenase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| Thioredoxin-like | 0 | Direct |
| Bacterial luciferase-like | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| Nqo1 middle domain-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| ALDH-like | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Dihydropteroate synthetase-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Mss4-like | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| Frataxin/Nqo15-like | 0 | Direct |
| "Helical backbone" metal receptor | 0 | Direct |
| HydA/Nqo6-like | 0 | Direct |
| Ribbon-helix-helix | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Methylamine dehydrogenase, L chain | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | Direct |
| Flavoproteins | 0 | Direct |
| Prismane protein-like | 0 | Direct |
| Multiheme cytochromes | 0 | Direct |
| HydB/Nqo4-like | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| Heme oxygenase-like | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | Direct |
| Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
| Fe-only hydrogenase | 0 | Direct |
| FAD-linked oxidoreductase | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| Copper amine oxidase, domain N | 0 | Direct |
| Clavaminate synthase-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| N-terminal domain of bifunctional PutA protein | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | Direct |
| Nqo5-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| Nqo1C-terminal domain-like | 0 | Direct |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | Direct |
| LigB-like | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| FMN-dependent nitroreductase-like | 0 | Direct |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Globin-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Photosystem I subunits PsaA/PsaB | 0 | Direct |
| YebC-like | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| ISP domain | 0 | Direct |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| AhpD-like | 0 | Direct |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | Direct |
| PFL-like glycyl radical enzymes | 0 | Direct |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| Nucleotide-binding domain | 0 | Direct |
| Methanol dehydrogenase subunit | 0 | Direct |
| Peptide methionine sulfoxide reductase | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Dihydrofolate reductase-like | 0 | Direct |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | Direct |
| alpha-helical ferredoxin | 0 | Direct |
| Cytochrome c oxidase subunit III-like | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Hemocyanin, N-terminal domain | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| Cytochrome c oxidase subunit I-like | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| Aromatic compound dioxygenase | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| ADC-like | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | Direct |
| Oxidoreductase molybdopterin-binding domain | 0 | Direct |
| NAD(P)-binding Rossmann-fold domains | 0 | Direct |
| Respiratory nitrate reductase 1 gamma chain | 0 | Direct |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| GroES-like | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| DinB/YfiT-like putative metalloenzymes | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Superoxide reductase-like | 0 | Direct |
| Calponin-homology domain, CH-domain | 0.000000000000006503 | Direct |
| PHM/PNGase F | 0.00000000000002171 | Direct |
| Nqo1 FMN-binding domain-like | 0.000000000001162 | Direct |
| Serine metabolism enzymes domain | 0.00000000009387 | Direct |
| Phosphotyrosine protein phosphatases I | 0.0000000001378 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0.0000000007957 | Direct |
| Rubredoxin-like | 0.00000006026 | Direct |
| C-type lectin-like | 0.00000009109 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0.0000001026 | Direct |
| SRCR-like | 0.0000002305 | Direct |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.000001337 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0.000003303 | Direct |
| ParB/Sulfiredoxin | 0.000008645 | Direct |
| NTF2-like | 0.00003039 | Direct |
| EGF/Laminin | 0.00005826 | Direct |
| Dimeric alpha+beta barrel | 0.001178 | Inherited |
| Lipocalins | 0.001839 | Inherited |
| TK C-terminal domain-like | 0.00197 | Inherited |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.002387 | Inherited |
| Galactose oxidase, central domain | 0.002727 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.005219 | Inherited |
| FnI-like domain | 0.005838 | Inherited |
| SCP-like | 0.008239 | Inherited |
| ACP-like | 0.0103 | Inherited |
| Nitrous oxide reductase, N-terminal domain | 0.01656 | Inherited |
| HSP20-like chaperones | 0.02137 | Inherited |
| HIT/MYND zinc finger-like | 0.06322 | Inherited |
| Electron transport accessory proteins | 0.1086 | Inherited |
| FYVE/PHD zinc finger | 0.2985 | Inherited |
| NHL repeat | 0.3172 | Inherited |
| TPR-like | 0.3981 | Inherited |
| HMA, heavy metal-associated domain | 0.4141 | Inherited |
| ARM repeat | 0.4393 | Inherited |
| Complement control module/SCR domain | 0.4453 | Inherited |
| Chorismate mutase II | 0.5385 | Inherited |
| SMAD/FHA domain | 0.5524 | Inherited |
| Tudor/PWWP/MBT | 0.716 | Inherited |
| RNI-like | 0.8363 | Inherited |
| FabD/lysophospholipase-like | 0.9164 | Inherited |
| Calcium-dependent phosphotriesterase | 0.9744 | Inherited |
| ACT-like | 0.9792 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| Radical SAM enzymes | 1 | Inherited |
| EF-hand | 1 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | Inherited |
| L domain-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| Aminomethyltransferase beta-barrel domain | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| all-alpha NTP pyrophosphatases | 1 | Inherited |
| ThiG-like | 1 | Inherited |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | Inherited |
| Adenine nucleotide alpha hydrolases-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| Homing endonucleases | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| E set domains | 1 | Inherited |
| 4'-phosphopantetheinyl transferase | 1 | Inherited |
| HisI-like | 1 | Inherited |
| FMT C-terminal domain-like | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| Ubiquitin-like | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Aldolase | 1 | Inherited |
| Enolase C-terminal domain-like | 1 | Inherited |
| Folate-binding domain | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Cytidine deaminase-like | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Hedgehog/intein (Hint) domain | 1 | Inherited |
| Cysteine-rich domain | 1 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 1 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 1 | Inherited |
| Carbamate kinase-like | 1 | Inherited |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | Inherited |
| Metallo-hydrolase/oxidoreductase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| Aminoacid dehydrogenases | 0 | DIRECT |
| Quinone reductase | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| PG130-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Aromatic compound dioxygenase | 0 | DIRECT |
| Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain | 0 | DIRECT |
| Monomeric isocitrate dehydrogenase | 0 | DIRECT |
| L-alanine dehydrogenase-like | 0 | DIRECT |
| Urate oxidase (uricase) | 0 | DIRECT |
| Nqo5-like | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain II | 0 | DIRECT |
| Flavodoxin-related | 0 | DIRECT |
| VWC domain | 0 | DIRECT |
| Proline dehydrohenase domain of bifunctional PutA protein | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Pirin-like | 0 | DIRECT |
| Desulforedoxin | 0 | DIRECT |
| Ssud-like monoxygenases | 0 | DIRECT |
| PHBH-like | 0 | DIRECT |
| Dyp-type peroxidase-like | 0 | DIRECT |
| Peptide methionine sulfoxide reductase | 0 | DIRECT |
| Bacterial luciferase (alkanal monooxygenase) | 0 | DIRECT |
| Catalase-peroxidase KatG | 0 | DIRECT |
| Dihydrofolate reductases | 0 | DIRECT |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Di-heme elbow motif | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| RibD C-terminal domain-like | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| D-lactate dehydrogenase | 0 | DIRECT |
| Glycine dehydrogenase subunits (GDC-P) | 0 | DIRECT |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
| Nickel-iron hydrogenase, small subunit | 0 | DIRECT |
| Manganese catalase (T-catalase) | 0 | DIRECT |
| Sulfiredoxin-like | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| HMD dimerization domain-like | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
| Nickel-iron hydrogenase, large subunit | 0 | DIRECT |
| Rubredoxin | 0 | DIRECT |
| Iron-containing alcohol dehydrogenase | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| Catechol oxidase | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Carbon monoxide dehydrogenase | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| C-terminal domain of adrenodoxin reductase-like | 0 | DIRECT |
| Mannitol 2-dehydrogenase | 0 | DIRECT |
| ETF-QO domain-like | 0 | DIRECT |
| LigB-like | 0 | DIRECT |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Cytochrome c oxidase subunit I-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Bacterial tryptophan 2,3-dioxygenase | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| Methylamine dehydrogenase, L chain | 0 | DIRECT |
| PBS lyase HEAT-like repeat | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, C-terminal domain | 0 | DIRECT |
| Extradiol dioxygenases | 0 | DIRECT |
| Copper amine oxidase, domain N | 0 | DIRECT |
| Glycerol-3-phosphate dehydrogenase | 0 | DIRECT |
| Nqo4-like | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| Catalase, C-terminal domain | 0 | DIRECT |
| Ring hydroxylating alpha subunit catalytic domain | 0 | DIRECT |
| Nitrosocyanin | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| PAPS reductase-like | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| Ring hydroxylating beta subunit | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| Superoxide reductase-like | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| Homogentisate dioxygenase | 0 | DIRECT |
| NirD-like | 0 | DIRECT |
| L-histidinol dehydrogenase HisD | 0 | DIRECT |
| Cytochrome c oxidase subunit III-like | 0 | DIRECT |
| Globins | 0 | DIRECT |
| Nqo1 middle domain-like | 0 | DIRECT |
| N-(1-D-carboxylethyl)-L-norvaline dehydrogenase | 0 | DIRECT |
| Homoserine dehydrogenase-like | 0 | DIRECT |
| Dihydropyrimidine dehydrogenase, N-terminal domain | 0 | DIRECT |
| Hybrid cluster protein (prismane protein) | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase dimerisation domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase, C-terminal domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| NADH:FMN oxidoreductase-like | 0 | DIRECT |
| TyrA dimerization domain-like | 0 | DIRECT |
| PhyH-like | 0 | DIRECT |
| Clavaminate synthase | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | DIRECT |
| Penicillin synthase-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Lipoxigenase N-terminal domain | 0 | DIRECT |
| NADPH-dependent FMN reductase | 0 | DIRECT |
| NADH oxidase/flavin reductase | 0 | DIRECT |
| Tyrosine-dependent oxidoreductases | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | DIRECT |
| Periplasmic domain of cytochrome c oxidase subunit II | 0 | DIRECT |
| Cysteine dioxygenase type I | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | DIRECT |
| PutA pre-N-terminal region-like | 0 | DIRECT |
| N-terminal domain of adrenodoxin reductase-like | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Electron transfer flavoprotein-ubiquinone oxidoreductase-like | 0 | DIRECT |
| Eukaryotic type heme oxygenase | 0 | DIRECT |
| 7-Fe ferredoxin | 0 | DIRECT |
| ArsC-like | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| 3-hydroxyanthranilic acid dioxygenase-like | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, C-terminal domain | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| Fe-only hydrogenase | 0 | DIRECT |
| N-terminal (heme c) domain of cytochrome cd1-nitrite reductase | 0 | DIRECT |
| Cytokinin dehydrogenase 1 | 0 | DIRECT |
| Thioltransferase | 0 | DIRECT |
| Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
| Ketopantoate reductase PanE | 0 | DIRECT |
| PFOR PP module | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0 | DIRECT |
| Ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Methylamine dehydrogenase, H-chain | 0 | DIRECT |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | DIRECT |
| Hemocyanin middle domain | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
| WrbA-like | 0 | DIRECT |
| Plant lipoxigenases | 0 | DIRECT |
| Animal lipoxigenases | 0 | DIRECT |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Ribonucleotide reductase-like | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| Acireductone dioxygenase | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| Frataxin-like | 0 | DIRECT |
| SelR domain | 0 | DIRECT |
| Hemocyanin, N-terminal domain | 0 | DIRECT |
| FAD-linked oxidases, N-terminal domain | 0 | DIRECT |
| Duplicated SiR/NiR-like domains 1 and 3 | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Aldo-keto reductases (NADP) | 0 | DIRECT |
| Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) | 0 | DIRECT |
| DsrA/DsrB N-terminal-domain-like | 0 | DIRECT |
| B12-dependent (class II) ribonucleotide reductase | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| SerA intervening domain-like | 0 | DIRECT |
| Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| Type II Proline 3-hydroxylase (proline oxidase) | 0 | DIRECT |
| Flavohemoglobin, C-terminal domain | 0 | DIRECT |
| Biliverdin reductase | 0 | DIRECT |
| Nqo1C-terminal domain-like | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| Ring hydroxylating alpha subunit ISP domain | 0 | DIRECT |
| PFOR Pyr module | 0 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | DIRECT |
| Nitrogenase iron-molybdenum protein | 0 | DIRECT |
| Haloperoxidase (bromoperoxidase) | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Respiratory nitrate reductase 1 gamma chain | 0 | DIRECT |
| Dihydrodipicolinate reductase-like | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Siroheme synthase N-terminal domain-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| NQO2-like | 0 | DIRECT |
| Indoleamine 2,3-dioxygenase-like | 0 | DIRECT |
| PNP-oxidase like | 0 | DIRECT |
| TauD/TfdA-like | 0 | DIRECT |
| Methylenetetrahydrofolate reductase | 0 | DIRECT |
| R67 dihydrofolate reductase | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Aromatic dioxygenase reductase-like | 0 | DIRECT |
| Glucose 6-phosphate dehydrogenase-like | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Cytochrome b5 | 0 | DIRECT |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0 | DIRECT |
| F420 dependent oxidoreductases | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | DIRECT |
| Class III anaerobic ribonucleotide reductase NRDD subunit | 0 | DIRECT |
| YebC-like | 0 | DIRECT |
| PqqC-like | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| C1-like domain | 0 | DIRECT |
| GMC oxidoreductases | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| N-terminal domain of bifunctional PutA protein | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| CCP-like | 0 | DIRECT |
| Asparaginyl hydroxylase-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | DIRECT |
| Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | DIRECT |
| Molybdenum-containing oxidoreductases-like dimerisation domain | 0 | DIRECT |
| Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | DIRECT |
| ProC C-terminal domain-like | 0 | DIRECT |
| Arthropod hemocyanin, C-terminal domain | 0 | DIRECT |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | DIRECT |
| Di-heme cytochrome c peroxidase | 0 | DIRECT |
| MioX-like | 0 | DIRECT |
| Gentisate 1,2-dioxygenase-like | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| AhpD | 0 | DIRECT |
| Shikimate dehydrogenase-like | 0 | DIRECT |
| PdxA-like | 0 | DIRECT |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| Glutathione peroxidase-like | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 1.855e-16 | DIRECT |
| Calponin-homology domain, CH-domain | 0.000000000000004716 | DIRECT |
| Nq06-like | 0.0000000000002343 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0.0000000000005145 | DIRECT |
| Nqo1 FMN-binding domain-like | 0.0000000000008766 | DIRECT |
| Ornithine cyclodeaminase-like | 0.00000000001617 | DIRECT |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0.00000000002645 | DIRECT |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.0000000002517 | DIRECT |
| Sulfatase-modifying factor-like | 0.000000002301 | DIRECT |
| AlkB-like | 0.000000004378 | DIRECT |
| MaoC-like | 0.0000000179 | DIRECT |
| Oxygen-independent coproporphyrinogen III oxidase HemN | 0.00000001967 | DIRECT |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0.0000000263 | DIRECT |
| Acyl-carrier protein (ACP) | 0.00004469 | DIRECT |
| Germin/Seed storage 7S protein | 0.00007901 | DIRECT |
| Haloperoxidase | 0.0001558 | DIRECT |
| EGF-type module | 0.0003129 | DIRECT |
| FabD-like | 0.001266 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase (NADH) || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors |
| Nitrous oxide reductase, N-terminal domain | 0.001814 | INHERITED FROM: Nitrous-oxide reductase || Acting on other nitrogenous compounds as donors || With a cytochrome as acceptor |
| Aspartokinase allosteric domain-like | 0.004493 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Homoserine dehydrogenase || Acting on the CH-OH group of donors |
| Sterol carrier protein, SCP | 0.007077 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || (3R)-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors |
| Ngr ectodomain-like | 0.009024 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.01136 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Acting on the CH-CH group of donors || Acting on the CH-OH group of donors |
| Deoxycytidylate deaminase-like | 0.02385 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 5-amino-6-(5-phosphoribosylamino)uracil reductase || Acting on the CH-OH group of donors |
| LIM domain | 0.04636 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With NADH or NADPH as one donor, and incorporation of one atom of oxygen || F-actin monooxygenase |
| Shikimate kinase (AroK) | 0.04684 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || Shikimate dehydrogenase |
| Peptidyl carrier domain | 0.06 | INHERITED FROM: L-2-aminoadipate reductase || Acting on the aldehyde or oxo group of donors || L-aminoadipate-semialdehyde dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| PDZ domain | 0.0875 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With NADH or NADPH as one donor, and incorporation of one atom of oxygen || Nitric-oxide synthase (NADPH) |
| Tudor domain | 0.1215 | INHERITED FROM: Delta(14)-sterol reductase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors |
| Dihydropteroate synthetase | 0.2436 | INHERITED FROM: Acting on CH or CH(2) groups || With an iron-sulfur protein as acceptor || (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) |
| NHL repeat | 0.2635 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With reduced ascorbate as one donor, and incorporation of one atom of oxygen || Peptidylglycine monooxygenase |
| Transketolase C-terminal domain-like | 0.2951 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || Pyruvate dehydrogenase (acetyl-transferring) || With a disulfide as acceptor |
| HMA, heavy metal-associated domain | 0.3838 | INHERITED FROM: Oxidizing metal ions || With NAD(+) or NADP(+) as acceptor || Mercury(II) reductase |
| Complement control module/SCR domain | 0.4132 | INHERITED FROM: Iodide peroxidase || Acting on a peroxide as acceptor || Peroxidases |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0.5817 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || Pyruvate dehydrogenase (acetyl-transferring) || With a disulfide as acceptor |
| Phosphotransacetylase | 0.583 | INHERITED FROM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) |
| FHA domain | 0.6136 | INHERITED FROM: Zeaxanthin epoxidase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
| PHD domain | 0.64 | INHERITED FROM: [Histone H3]-dimethyl-L-lysine(36) demethylase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Tetratricopeptide repeat (TPR) | 0.7089 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Procollagen-proline 4-dioxygenase |
| TK-like Pyr module | 0.7778 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || Pyruvate dehydrogenase (acetyl-transferring) || With a disulfide as acceptor |
| 4HBT-like | 0.803 | INHERITED FROM: Carnitine 3-dehydrogenase |
| Dehydroquinate synthase, DHQS | 0.9376 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || Shikimate dehydrogenase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.9379 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || Acting on the CH-CH group of donors |
| MoCo biosynthesis proteins | 0.945 | INHERITED FROM: With other, known acceptors || Catalyzing the reaction X-H + Y-H = 'X-Y' |
| Calmodulin-like | 0.971 | INHERITED FROM: With oxygen as acceptor || NAD(P)H oxidase (H(2)O(2)-forming) || Acting on NADH or NADPH |
| Cell cycle control phosphatase, catalytic domain | 0.9825 | INHERITED FROM: Acting on phosphorus or arsenic in donors || Arsenate reductase (glutaredoxin) || With disulfide as acceptor |
| Tandem AAA-ATPase domain | 1 | INHERITED FROM: Thymine dioxygenase |
| D-glucarate dehydratase-like | 1 | INHERITED FROM: With an iron-sulfur protein as acceptor || (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) |
| Glutathione S-transferase (GST), C-terminal domain | 1 | INHERITED FROM: Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With a quinone or similar compound as acceptor || Methylarsonate reductase || With disulfide as acceptor || Acting on a sulfur group of donors |
| ThiG-like | 1 | INHERITED FROM: Glycine oxidase |
| PyrH-like | 1 | INHERITED FROM: Homoserine dehydrogenase || Glutamate-5-semialdehyde dehydrogenase |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Firefly luciferase || L-2-aminoadipate reductase || With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase || L-aminoadipate-semialdehyde dehydrogenase |
| TK-like PP module | 1 | INHERITED FROM: Pyruvate dehydrogenase (acetyl-transferring) || With a disulfide as acceptor |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 1 | INHERITED FROM: Persulfide dioxygenase |
| Thiolase-related | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Class II glutamine amidotransferases | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Glutamate synthase (NADPH) || Glutamate synthase (NADH) || With an iron-sulfur protein as acceptor || Acting on the CH-NH(2) group of donors |
| E-set domains of sugar-utilizing enzymes | 1 | INHERITED FROM: Miscellaneous |
| Class I aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Cold shock DNA-binding domain-like | 1 | INHERITED FROM: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| Post formyltransferase domain | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
| GTP cyclohydrolase I | 1 | INHERITED FROM: PreQ(1) synthase || Acting on other nitrogenous compounds as donors || With NAD(+) or NADP(+) as acceptor |
| CAT-like | 1 | INHERITED FROM: Oxoglutarate dehydrogenase (succinyl-transferring) || Acting on the aldehyde or oxo group of donors || With a disulfide as acceptor |
| I set domains | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With oxygen as acceptor || With a flavin as acceptor || Acting on the CH-NH group of donors |
| Formyltransferase | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
| Enolpyruvate transferase, EPT | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-OH group of donors || Shikimate dehydrogenase |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| NagB-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase (NAD(P)(+)) || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| Holo-(acyl carrier protein) synthase ACPS | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrofolate reductase || Acting on the CH-NH group of donors |
| Aminomethyltransferase folate-binding domain | 1 | INHERITED FROM: With oxygen as acceptor || With a flavin as acceptor || Acting on the CH-NH group of donors |
| Nitrogenase iron protein-like | 1 | INHERITED FROM: Acting on iron-sulfur proteins as donors || Acting on the CH-CH group of donors || With an iron-sulfur protein as acceptor || With dinitrogen as acceptor |
| HisE-like (PRA-PH) | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Glutathione S-transferase (GST), N-terminal domain | 1 | INHERITED FROM: Glutathione dehydrogenase (ascorbate) || Acting on phosphorus or arsenic in donors || With a quinone or similar compound as acceptor || Methylarsonate reductase || With disulfide as acceptor || Acting on a sulfur group of donors |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| Aminoacid dehydrogenases | 0 | Direct |
| Quinone reductase | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| PG130-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Aromatic compound dioxygenase | 0 | Direct |
| Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain | 0 | Direct |
| Monomeric isocitrate dehydrogenase | 0 | Direct |
| L-alanine dehydrogenase-like | 0 | Direct |
| Urate oxidase (uricase) | 0 | Direct |
| Nqo5-like | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain II | 0 | Direct |
| Flavodoxin-related | 0 | Direct |
| VWC domain | 0 | Direct |
| Proline dehydrohenase domain of bifunctional PutA protein | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Pirin-like | 0 | Direct |
| Desulforedoxin | 0 | Direct |
| Ssud-like monoxygenases | 0 | Direct |
| PHBH-like | 0 | Direct |
| Dyp-type peroxidase-like | 0 | Direct |
| Peptide methionine sulfoxide reductase | 0 | Direct |
| Bacterial luciferase (alkanal monooxygenase) | 0 | Direct |
| Catalase-peroxidase KatG | 0 | Direct |
| Dihydrofolate reductases | 0 | Direct |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Di-heme elbow motif | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| RibD C-terminal domain-like | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| D-lactate dehydrogenase | 0 | Direct |
| Glycine dehydrogenase subunits (GDC-P) | 0 | Direct |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
| Nickel-iron hydrogenase, small subunit | 0 | Direct |
| Manganese catalase (T-catalase) | 0 | Direct |
| Sulfiredoxin-like | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
| HMD dimerization domain-like | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
| Nickel-iron hydrogenase, large subunit | 0 | Direct |
| Rubredoxin | 0 | Direct |
| Iron-containing alcohol dehydrogenase | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| Catechol oxidase | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Carbon monoxide dehydrogenase | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| C-terminal domain of adrenodoxin reductase-like | 0 | Direct |
| Mannitol 2-dehydrogenase | 0 | Direct |
| ETF-QO domain-like | 0 | Direct |
| LigB-like | 0 | Direct |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| Cytochrome c oxidase subunit I-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Bacterial tryptophan 2,3-dioxygenase | 0 | Direct |
| Methanol dehydrogenase subunit | 0 | Direct |
| Ferritin | 0 | Direct |
| Methylamine dehydrogenase, L chain | 0 | Direct |
| PBS lyase HEAT-like repeat | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, C-terminal domain | 0 | Direct |
| Extradiol dioxygenases | 0 | Direct |
| Copper amine oxidase, domain N | 0 | Direct |
| Glycerol-3-phosphate dehydrogenase | 0 | Direct |
| Nqo4-like | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| Catalase, C-terminal domain | 0 | Direct |
| Ring hydroxylating alpha subunit catalytic domain | 0 | Direct |
| Nitrosocyanin | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| PAPS reductase-like | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| Ring hydroxylating beta subunit | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| Superoxide reductase-like | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| Homogentisate dioxygenase | 0 | Direct |
| NirD-like | 0 | Direct |
| L-histidinol dehydrogenase HisD | 0 | Direct |
| Cytochrome c oxidase subunit III-like | 0 | Direct |
| Globins | 0 | Direct |
| Nqo1 middle domain-like | 0 | Direct |
| N-(1-D-carboxylethyl)-L-norvaline dehydrogenase | 0 | Direct |
| Homoserine dehydrogenase-like | 0 | Direct |
| Dihydropyrimidine dehydrogenase, N-terminal domain | 0 | Direct |
| Hybrid cluster protein (prismane protein) | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase dimerisation domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase, C-terminal domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| NADH:FMN oxidoreductase-like | 0 | Direct |
| TyrA dimerization domain-like | 0 | Direct |
| PhyH-like | 0 | Direct |
| Clavaminate synthase | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | Direct |
| Penicillin synthase-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Lipoxigenase N-terminal domain | 0 | Direct |
| NADPH-dependent FMN reductase | 0 | Direct |
| NADH oxidase/flavin reductase | 0 | Direct |
| Tyrosine-dependent oxidoreductases | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | Direct |
| Periplasmic domain of cytochrome c oxidase subunit II | 0 | Direct |
| Cysteine dioxygenase type I | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | Direct |
| PutA pre-N-terminal region-like | 0 | Direct |
| N-terminal domain of adrenodoxin reductase-like | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Electron transfer flavoprotein-ubiquinone oxidoreductase-like | 0 | Direct |
| Eukaryotic type heme oxygenase | 0 | Direct |
| 7-Fe ferredoxin | 0 | Direct |
| ArsC-like | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| 3-hydroxyanthranilic acid dioxygenase-like | 0 | Direct |
| R1 subunit of ribonucleotide reductase, C-terminal domain | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| Fe-only hydrogenase | 0 | Direct |
| N-terminal (heme c) domain of cytochrome cd1-nitrite reductase | 0 | Direct |
| Cytokinin dehydrogenase 1 | 0 | Direct |
| Thioltransferase | 0 | Direct |
| Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
| Ketopantoate reductase PanE | 0 | Direct |
| PFOR PP module | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| FAD-linked reductases, N-terminal domain | 0 | Direct |
| Ferredoxin domains from multidomain proteins | 0 | Direct |
| Methylamine dehydrogenase, H-chain | 0 | Direct |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | Direct |
| Hemocyanin middle domain | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
| WrbA-like | 0 | Direct |
| Plant lipoxigenases | 0 | Direct |
| Animal lipoxigenases | 0 | Direct |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Ribonucleotide reductase-like | 0 | Direct |
| Crotonase-like | 0 | Direct |
| Acireductone dioxygenase | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| Frataxin-like | 0 | Direct |
| SelR domain | 0 | Direct |
| Hemocyanin, N-terminal domain | 0 | Direct |
| FAD-linked oxidases, N-terminal domain | 0 | Direct |
| Duplicated SiR/NiR-like domains 1 and 3 | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Aldo-keto reductases (NADP) | 0 | Direct |
| Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) | 0 | Direct |
| DsrA/DsrB N-terminal-domain-like | 0 | Direct |
| B12-dependent (class II) ribonucleotide reductase | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| SerA intervening domain-like | 0 | Direct |
| Oxidoreductase molybdopterin-binding domain | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| Type II Proline 3-hydroxylase (proline oxidase) | 0 | Direct |
| Flavohemoglobin, C-terminal domain | 0 | Direct |
| Biliverdin reductase | 0 | Direct |
| Nqo1C-terminal domain-like | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| Ring hydroxylating alpha subunit ISP domain | 0 | Direct |
| PFOR Pyr module | 0 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | Direct |
| Nitrogenase iron-molybdenum protein | 0 | Direct |
| Haloperoxidase (bromoperoxidase) | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Respiratory nitrate reductase 1 gamma chain | 0 | Direct |
| Dihydrodipicolinate reductase-like | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Siroheme synthase N-terminal domain-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| NQO2-like | 0 | Direct |
| Indoleamine 2,3-dioxygenase-like | 0 | Direct |
| PNP-oxidase like | 0 | Direct |
| TauD/TfdA-like | 0 | Direct |
| Methylenetetrahydrofolate reductase | 0 | Direct |
| R67 dihydrofolate reductase | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Aromatic dioxygenase reductase-like | 0 | Direct |
| Glucose 6-phosphate dehydrogenase-like | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Cytochrome b5 | 0 | Direct |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0 | Direct |
| F420 dependent oxidoreductases | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | Direct |
| Class III anaerobic ribonucleotide reductase NRDD subunit | 0 | Direct |
| YebC-like | 0 | Direct |
| PqqC-like | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| C1-like domain | 0 | Direct |
| GMC oxidoreductases | 0 | Direct |
| GAPDH-like | 0 | Direct |
| N-terminal domain of bifunctional PutA protein | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| CCP-like | 0 | Direct |
| Asparaginyl hydroxylase-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | Direct |
| Photosystem I subunits PsaA/PsaB | 0 | Direct |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | Direct |
| Molybdenum-containing oxidoreductases-like dimerisation domain | 0 | Direct |
| Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain | 0 | Direct |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | Direct |
| ProC C-terminal domain-like | 0 | Direct |
| Arthropod hemocyanin, C-terminal domain | 0 | Direct |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | Direct |
| Di-heme cytochrome c peroxidase | 0 | Direct |
| MioX-like | 0 | Direct |
| Gentisate 1,2-dioxygenase-like | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| AhpD | 0 | Direct |
| Shikimate dehydrogenase-like | 0 | Direct |
| PdxA-like | 0 | Direct |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| Glutathione peroxidase-like | 0 | Direct |
| Reductases | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 1.855e-16 | Direct |
| Calponin-homology domain, CH-domain | 0.000000000000004716 | Direct |
| Nq06-like | 0.0000000000002343 | Direct |
| Phenylalanine metabolism regulatory domain | 0.0000000000005145 | Direct |
| Nqo1 FMN-binding domain-like | 0.0000000000008766 | Direct |
| Ornithine cyclodeaminase-like | 0.00000000001617 | Direct |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0.00000000002645 | Direct |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.0000000002517 | Direct |
| Sulfatase-modifying factor-like | 0.000000002301 | Direct |
| AlkB-like | 0.000000004378 | Direct |
| MaoC-like | 0.0000000179 | Direct |
| Oxygen-independent coproporphyrinogen III oxidase HemN | 0.00000001967 | Direct |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0.0000000263 | Direct |
| Acyl-carrier protein (ACP) | 0.00004469 | Direct |
| Germin/Seed storage 7S protein | 0.00007901 | Direct |
| Haloperoxidase | 0.0001558 | Direct |
| EGF-type module | 0.0003129 | Direct |
| FabD-like | 0.001266 | Inherited |
| Nitrous oxide reductase, N-terminal domain | 0.001814 | Inherited |
| Aspartokinase allosteric domain-like | 0.004493 | Inherited |
| Sterol carrier protein, SCP | 0.007077 | Inherited |
| Ngr ectodomain-like | 0.009024 | Inherited |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.01136 | Inherited |
| Deoxycytidylate deaminase-like | 0.02385 | Inherited |
| LIM domain | 0.04636 | Inherited |
| Shikimate kinase (AroK) | 0.04684 | Inherited |
| Peptidyl carrier domain | 0.06 | Inherited |
| PDZ domain | 0.0875 | Inherited |
| Tudor domain | 0.1215 | Inherited |
| Dihydropteroate synthetase | 0.2436 | Inherited |
| NHL repeat | 0.2635 | Inherited |
| Transketolase C-terminal domain-like | 0.2951 | Inherited |
| HMA, heavy metal-associated domain | 0.3838 | Inherited |
| Complement control module/SCR domain | 0.4132 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0.5817 | Inherited |
| Phosphotransacetylase | 0.583 | Inherited |
| FHA domain | 0.6136 | Inherited |
| PHD domain | 0.64 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.7089 | Inherited |
| TK-like Pyr module | 0.7778 | Inherited |
| 4HBT-like | 0.803 | Inherited |
| Dehydroquinate synthase, DHQS | 0.9376 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.9379 | Inherited |
| MoCo biosynthesis proteins | 0.945 | Inherited |
| Calmodulin-like | 0.971 | Inherited |
| Cell cycle control phosphatase, catalytic domain | 0.9825 | Inherited |
| Tandem AAA-ATPase domain | 1 | Inherited |
| D-glucarate dehydratase-like | 1 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 1 | Inherited |
| ThiG-like | 1 | Inherited |
| PyrH-like | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| TK-like PP module | 1 | Inherited |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 1 | Inherited |
| Thiolase-related | 1 | Inherited |
| Class II glutamine amidotransferases | 1 | Inherited |
| E-set domains of sugar-utilizing enzymes | 1 | Inherited |
| Class I aldolase | 1 | Inherited |
| Cold shock DNA-binding domain-like | 1 | Inherited |
| Post formyltransferase domain | 1 | Inherited |
| GTP cyclohydrolase I | 1 | Inherited |
| CAT-like | 1 | Inherited |
| I set domains | 1 | Inherited |
| Aminomethyltransferase beta-barrel domain | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| Enolpyruvate transferase, EPT | 1 | Inherited |
| HisI-like | 1 | Inherited |
| NagB-like | 1 | Inherited |
| Holo-(acyl carrier protein) synthase ACPS | 1 | Inherited |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | Inherited |
| Aminomethyltransferase folate-binding domain | 1 | Inherited |
| Nitrogenase iron protein-like | 1 | Inherited |
| HisE-like (PRA-PH) | 1 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| Peptide methionine sulfoxide reductase | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
| Thioredoxin-like | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Nqo1 middle domain-like | 0 | DIRECT |
| Heme oxygenase-like | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| Methylamine dehydrogenase, L chain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Cytochrome c oxidase subunit I-like | 0 | DIRECT |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | DIRECT |
| LigB-like | 0 | DIRECT |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | DIRECT |
| Aromatic compound dioxygenase | 0 | DIRECT |
| Nucleotide-binding domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Dihydrofolate reductase-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Hemocyanin, N-terminal domain | 0 | DIRECT |
| YebC-like | 0 | DIRECT |
| Nqo1C-terminal domain-like | 0 | DIRECT |
| Copper amine oxidase, domain N | 0 | DIRECT |
| Cytochrome c oxidase subunit III-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| HydA/Nqo6-like | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Respiratory nitrate reductase 1 gamma chain | 0 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
| Multiheme cytochromes | 0 | DIRECT |
| Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Nqo5-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| HydB/Nqo4-like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Superoxide reductase-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | DIRECT |
| Bacterial luciferase-like | 0 | DIRECT |
| FMN-dependent nitroreductase-like | 0 | DIRECT |
| Clavaminate synthase-like | 0 | DIRECT |
| "Helical backbone" metal receptor | 0 | DIRECT |
| Dihydropteroate synthetase-like | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| DinB/YfiT-like putative metalloenzymes | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Ribbon-helix-helix | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | DIRECT |
| Prismane protein-like | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Globin-like | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | DIRECT |
| N-terminal domain of bifunctional PutA protein | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | DIRECT |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| alpha-helical ferredoxin | 0 | DIRECT |
| Fe-only hydrogenase | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| PFL-like glycyl radical enzymes | 0 | DIRECT |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Frataxin/Nqo15-like | 0 | DIRECT |
| Calponin-homology domain, CH-domain | 0.000000000000004551 | DIRECT |
| PHM/PNGase F | 0.0000000000000153 | DIRECT |
| Nqo1 FMN-binding domain-like | 0.0000000000008335 | DIRECT |
| Serine metabolism enzymes domain | 0.00000000006892 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0.0000000001014 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.0000000005913 | DIRECT |
| Rubredoxin-like | 0.00000004594 | DIRECT |
| C-type lectin-like | 0.00000006951 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0.0000000784 | DIRECT |
| SRCR-like | 0.0000001773 | DIRECT |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.000001043 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.000002595 | DIRECT |
| ParB/Sulfiredoxin | 0.000006822 | DIRECT |
| NTF2-like | 0.00002423 | DIRECT |
| EGF/Laminin | 0.0000467 | DIRECT |
| Dimeric alpha+beta barrel | 0.0009731 | DIRECT |
| Lipocalins | 0.001528 | INHERITED FROM: With a quinone or similar compound as acceptor || Reducing C-O-C group as acceptor |
| TK C-terminal domain-like | 0.001638 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || With an iron-sulfur protein as acceptor || Assimilatory sulfite reductase (NADPH) || With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.001988 | INHERITED FROM: Acting on other nitrogenous compounds as donors || With other acceptors || Nitrite reductase (NO-forming) || With a cytochrome as acceptor |
| Galactose oxidase, central domain | 0.002276 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || With oxygen as acceptor || Aldehyde oxidase |
| FnI-like domain | 0.004908 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| SCP-like | 0.006959 | INHERITED FROM: (3R)-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
| ACP-like | 0.008725 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || L-2-aminoadipate reductase || Formyltetrahydrofolate dehydrogenase || 3-oxoacyl-[acyl-carrier-protein] reductase || Acting on the aldehyde or oxo group of donors || With NAD(+) or NADP(+) as acceptor || L-aminoadipate-semialdehyde dehydrogenase || With NAD(+) or NADP(+) as acceptor || Acting on the CH-NH group of donors || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Nitrous oxide reductase, N-terminal domain | 0.01411 | INHERITED FROM: Nitrous-oxide reductase || Acting on other nitrogenous compounds as donors || With a cytochrome as acceptor |
| HSP20-like chaperones | 0.01826 | INHERITED FROM: Cytochrome-b5 reductase || Acting on NADH or NADPH || With a heme protein as acceptor |
| HIT/MYND zinc finger-like | 0.05483 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Hypoxia-inducible factor-proline dioxygenase || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Electron transport accessory proteins | 0.09487 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrofolate reductase || Acting on the CH-NH group of donors |
| FYVE/PHD zinc finger | 0.2693 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || [Histone H3]-dimethyl-L-lysine(36) demethylase || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| NHL repeat | 0.2865 | INHERITED FROM: With reduced ascorbate as one donor, and incorporation of one atom of oxygen || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Peptidylglycine monooxygenase |
| TPR-like | 0.3607 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Procollagen-proline 3-dioxygenase || Peptide-aspartate beta-dioxygenase || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Procollagen-proline 4-dioxygenase |
| HMA, heavy metal-associated domain | 0.3756 | INHERITED FROM: Oxidizing metal ions || With NAD(+) or NADP(+) as acceptor || Mercury(II) reductase |
| ARM repeat | 0.3994 | INHERITED FROM: Epoxyqueuosine reductase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Deoxyhypusine monooxygenase || With other acceptors || Miscellaneous |
| Complement control module/SCR domain | 0.405 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Iodide peroxidase |
| Chorismate mutase II | 0.4929 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || Prephenate dehydrogenase |
| SMAD/FHA domain | 0.5058 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Zeaxanthin epoxidase || With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
| Tudor/PWWP/MBT | 0.6585 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || Delta(14)-sterol reductase |
| RNI-like | 0.7707 | INHERITED FROM: Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || [Histone H3]-dimethyl-L-lysine(36) demethylase || With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| FabD/lysophospholipase-like | 0.8464 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Calcium-dependent phosphotriesterase | 0.9017 | INHERITED FROM: With reduced ascorbate as one donor, and incorporation of one atom of oxygen || Peptidylglycine monooxygenase |
| ACT-like | 0.9064 | INHERITED FROM: With reduced pteridine as one donor, and incorporation of one atom of oxygen || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || 2-oxoglutarate reductase || Homoserine dehydrogenase || Prephenate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Phosphoglycerate dehydrogenase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.9301 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Homing endonucleases | 0.9376 | INHERITED FROM: Acting on CH or CH(2) groups || With a disulfide as acceptor || Ribonucleoside-diphosphate reductase |
| Adenine nucleotide alpha hydrolases-like | 1 | INHERITED FROM: Acting on a sulfur group of donors || Phosphoadenylyl-sulfate reductase (thioredoxin) || With a disulfide as acceptor |
| ClpP/crotonase | 1 | INHERITED FROM: 3-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || Long-chain-3-hydroxyacyl-CoA dehydrogenase |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Bromide peroxidase |
| PLP-dependent transferases | 1 | INHERITED FROM: Acting on the CH-NH(2) group of donors || With a disulfide as acceptor |
| Hedgehog/intein (Hint) domain | 1 | INHERITED FROM: Acting on CH or CH(2) groups || With a disulfide as acceptor || Ribonucleoside-diphosphate reductase |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase (NAD(P)(+)) || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| Cysteine-rich domain | 1 | INHERITED FROM: Protein-disulfide reductase || Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor |
| Immunoglobulin | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| Folate-binding domain | 1 | INHERITED FROM: With a flavin as acceptor || With oxygen as acceptor || Acting on the CH-NH group of donors |
| EF-hand | 1 | INHERITED FROM: With a quinone or similar compound as acceptor || NADH:ubiquinone reductase (non-electrogenic) || With H(2)O(2) as acceptor, one oxygen atom of which is incorporated into the product || NAD(P)H oxidase (H(2)O(2)-forming) || Plant seed peroxygenase || Glycerol-3-phosphate dehydrogenase || Acting on NADH or NADPH || With oxygen as acceptor |
| 4'-phosphopantetheinyl transferase | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Radical SAM enzymes | 1 | INHERITED FROM: [Formate-C-acetyltransferase]-activating enzyme || Coproporphyrinogen dehydrogenase || With other, known acceptors || Catalyzing the reaction X-H + Y-H = 'X-Y' || With other, known, acceptors |
| Ubiquitin-like | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Very-long-chain enoyl-CoA reductase |
| Aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Formyltransferase | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
| E set domains | 1 | INHERITED FROM: Nitrate reductase (NADPH) || Acting on other nitrogenous compounds as donors || Sulfite oxidase || With oxygen as acceptor || With oxygen as acceptor || With another compound as one donor, and incorporation of one atom of oxygen || Tyrosinase || With NAD(+) or NADP(+) as acceptor || Nitrate reductase (NADH) || Aldehyde oxidase |
| all-alpha NTP pyrophosphatases | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Carbamate kinase-like | 1 | INHERITED FROM: Homoserine dehydrogenase || Glutamate-5-semialdehyde dehydrogenase |
| ThiG-like | 1 | INHERITED FROM: Glycine oxidase |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | INHERITED FROM: Acting on the CH-NH(2) group of donors || Glutamate synthase (NADH) || Glutamate synthase (NADPH) || With NAD(+) or NADP(+) as acceptor || With an iron-sulfur protein as acceptor |
| Enolase C-terminal domain-like | 1 | INHERITED FROM: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) || With an iron-sulfur protein as acceptor || Acting on CH or CH(2) groups |
| GST C-terminal domain-like | 1 | INHERITED FROM: With disulfide as acceptor || Acting on phosphorus or arsenic in donors || With a quinone or similar compound as acceptor || Acting on a sulfur group of donors || Methylarsonate reductase || Glutathione dehydrogenase (ascorbate) |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Chloride peroxidase || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Cytidine deaminase-like | 1 | INHERITED FROM: 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: With dinitrogen as acceptor || Ferredoxin:protochlorophyllide reductase (ATP-dependent) || Shikimate dehydrogenase || Thymine dioxygenase || Acting on iron-sulfur proteins as donors || With an iron-sulfur protein as acceptor |
| Metallo-hydrolase/oxidoreductase | 1 | INHERITED FROM: With another compound as one donor, and incorporation of one atom of oxygen || CMP-N-acetylneuraminate monooxygenase || Persulfide dioxygenase |
| Rhodanese/Cell cycle control phosphatase | 1 | INHERITED FROM: With disulfide as acceptor || Acting on phosphorus or arsenic in donors || Arsenate reductase (glutaredoxin) |
| EPT/RTPC-like | 1 | INHERITED FROM: Shikimate dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: F-actin monooxygenase || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || With NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors || Procollagen-lysine 5-dioxygenase |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrofolate reductase || Acting on the CH-NH group of donors |
| HD-domain/PDEase-like | 1 | INHERITED FROM: Miscellaneous || Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || (3R)-hydroxyacyl-CoA dehydrogenase || Carnitine 3-dehydrogenase |
| L domain-like | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: L-2-aminoadipate reductase || Acting on the aldehyde or oxo group of donors || Oxoglutarate dehydrogenase (succinyl-transferring) || L-aminoadipate-semialdehyde dehydrogenase || With a disulfide as acceptor |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Catalase |
| PDZ domain-like | 1 | INHERITED FROM: Nitric-oxide synthase (NADPH) || With NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| Thiolase-like | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: L-2-aminoadipate reductase || With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase || L-aminoadipate-semialdehyde dehydrogenase || Firefly luciferase |
| FMT C-terminal domain-like | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
| Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With a flavin as acceptor || With oxygen as acceptor || Acting on the CH-NH group of donors |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
| Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Methanol dehydrogenase subunit | 0 | Direct |
| Peptide methionine sulfoxide reductase | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| AhpD-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
| Thioredoxin-like | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| Nqo1 middle domain-like | 0 | Direct |
| Heme oxygenase-like | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| Methylamine dehydrogenase, L chain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Cytochrome c oxidase subunit I-like | 0 | Direct |
| Ferredoxin thioredoxin reductase (FTR), catalytic beta chain | 0 | Direct |
| LigB-like | 0 | Direct |
| Glutamyl tRNA-reductase catalytic, N-terminal domain | 0 | Direct |
| Aromatic compound dioxygenase | 0 | Direct |
| Nucleotide-binding domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
| NAD(P)-linked oxidoreductase | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), N-terminal domain | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Dihydrofolate reductase-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Hemocyanin, N-terminal domain | 0 | Direct |
| YebC-like | 0 | Direct |
| Nqo1C-terminal domain-like | 0 | Direct |
| Copper amine oxidase, domain N | 0 | Direct |
| Cytochrome c oxidase subunit III-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Alpha subunit of glutamate synthase, C-terminal domain | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| HydA/Nqo6-like | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Oxidoreductase molybdopterin-binding domain | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Respiratory nitrate reductase 1 gamma chain | 0 | Direct |
| NAD(P)-binding Rossmann-fold domains | 0 | Direct |
| Multiheme cytochromes | 0 | Direct |
| Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Nqo5-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Cupredoxins | 0 | Direct |
| HydB/Nqo4-like | 0 | Direct |
| ADC-like | 0 | Direct |
| Mss4-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Superoxide reductase-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| R1 subunit of ribonucleotide reductase, N-terminal domain | 0 | Direct |
| Bacterial luciferase-like | 0 | Direct |
| FMN-dependent nitroreductase-like | 0 | Direct |
| Clavaminate synthase-like | 0 | Direct |
| "Helical backbone" metal receptor | 0 | Direct |
| Dihydropteroate synthetase-like | 0 | Direct |
| FAD-linked oxidoreductase | 0 | Direct |
| GroES-like | 0 | Direct |
| DinB/YfiT-like putative metalloenzymes | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| Bacterial photosystem II reaction centre, L and M subunits | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Ribbon-helix-helix | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) | 0 | Direct |
| Prismane protein-like | 0 | Direct |
| ISP domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Globin-like | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit IV | 0 | Direct |
| N-terminal domain of bifunctional PutA protein | 0 | Direct |
| Flavoproteins | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) | 0 | Direct |
| Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| alpha-helical ferredoxin | 0 | Direct |
| Fe-only hydrogenase | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
| Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
| Aldehyde ferredoxin oxidoreductase, N-terminal domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Photosystem I subunits PsaA/PsaB | 0 | Direct |
| ALDH-like | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| PFL-like glycyl radical enzymes | 0 | Direct |
| Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Frataxin/Nqo15-like | 0 | Direct |
| Calponin-homology domain, CH-domain | 0.000000000000004551 | Direct |
| PHM/PNGase F | 0.0000000000000153 | Direct |
| Nqo1 FMN-binding domain-like | 0.0000000000008335 | Direct |
| Serine metabolism enzymes domain | 0.00000000006892 | Direct |
| Phosphotyrosine protein phosphatases I | 0.0000000001014 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0.0000000005913 | Direct |
| Rubredoxin-like | 0.00000004594 | Direct |
| C-type lectin-like | 0.00000006951 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0.0000000784 | Direct |
| SRCR-like | 0.0000001773 | Direct |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.000001043 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0.000002595 | Direct |
| ParB/Sulfiredoxin | 0.000006822 | Direct |
| NTF2-like | 0.00002423 | Direct |
| EGF/Laminin | 0.0000467 | Direct |
| Dimeric alpha+beta barrel | 0.0009731 | Direct |
| Lipocalins | 0.001528 | Inherited |
| TK C-terminal domain-like | 0.001638 | Inherited |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.001988 | Inherited |
| Galactose oxidase, central domain | 0.002276 | Inherited |
| FnI-like domain | 0.004908 | Inherited |
| SCP-like | 0.006959 | Inherited |
| ACP-like | 0.008725 | Inherited |
| Nitrous oxide reductase, N-terminal domain | 0.01411 | Inherited |
| HSP20-like chaperones | 0.01826 | Inherited |
| HIT/MYND zinc finger-like | 0.05483 | Inherited |
| Electron transport accessory proteins | 0.09487 | Inherited |
| FYVE/PHD zinc finger | 0.2693 | Inherited |
| NHL repeat | 0.2865 | Inherited |
| TPR-like | 0.3607 | Inherited |
| HMA, heavy metal-associated domain | 0.3756 | Inherited |
| ARM repeat | 0.3994 | Inherited |
| Complement control module/SCR domain | 0.405 | Inherited |
| Chorismate mutase II | 0.4929 | Inherited |
| SMAD/FHA domain | 0.5058 | Inherited |
| Tudor/PWWP/MBT | 0.6585 | Inherited |
| RNI-like | 0.7707 | Inherited |
| FabD/lysophospholipase-like | 0.8464 | Inherited |
| Calcium-dependent phosphotriesterase | 0.9017 | Inherited |
| ACT-like | 0.9064 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.9301 | Inherited |
| Homing endonucleases | 0.9376 | Inherited |
| Adenine nucleotide alpha hydrolases-like | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Hedgehog/intein (Hint) domain | 1 | Inherited |
| HisI-like | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Cysteine-rich domain | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Folate-binding domain | 1 | Inherited |
| EF-hand | 1 | Inherited |
| 4'-phosphopantetheinyl transferase | 1 | Inherited |
| Radical SAM enzymes | 1 | Inherited |
| Ubiquitin-like | 1 | Inherited |
| Aldolase | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| E set domains | 1 | Inherited |
| all-alpha NTP pyrophosphatases | 1 | Inherited |
| Carbamate kinase-like | 1 | Inherited |
| ThiG-like | 1 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | Inherited |
| Enolase C-terminal domain-like | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| Cytidine deaminase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Metallo-hydrolase/oxidoreductase | 1 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 1 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| Thymidylate synthase/dCMP hydroxymethylase | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | Inherited |
| L domain-like | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| FMT C-terminal domain-like | 1 | Inherited |
| Aminomethyltransferase beta-barrel domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48168,51998
48168 - R1 subunit of ribonucleotide reductase, N-terminal domain
51998 - PFL-like glycyl radical enzymes | 0 | DIRECT |
55447,54665
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
48179,54637
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
55383,54416
55383 - Copper amine oxidase, domain N
54416 - Amine oxidase N-terminal region | 0 | DIRECT |
50022,56281
50022 - ISP domain
56281 - Metallo-hydrolase/oxidoreductase | 0 | DIRECT |
54862,52518
54862 - 4Fe-4S ferredoxins
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
56524,81296
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
51905,51905
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
55347,55021
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
55124,54862
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
46626,51004
46626 - Cytochrome c
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0 | DIRECT |
47336,53720
47336 - ACP-like
53720 - ALDH-like | 0 | DIRECT |
52922,53323
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
54416,49998
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | DIRECT |
49503,-7
49503 - Cupredoxins
-7 - CATH | 0 | DIRECT |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
56634,52317
56634 - Heme-dependent catalase-like
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
69742,51735
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
55124,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
51971,51395
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
51182,51182
51182 - RmlC-like cupins
51182 - RmlC-like cupins | 0 | DIRECT |
55068,51316
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | DIRECT |
75625,51998
75625 - YebC-like
51998 - PFL-like glycyl radical enzymes | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
142019,142984
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
56176,55447
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
54862,51395
54862 - 4Fe-4S ferredoxins
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
47576,57716
47576 - Calponin-homology domain, CH-domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
54292,46548
54292 - 2Fe-2S ferredoxin-like
46548 - alpha-helical ferredoxin | 0 | DIRECT |
52402,52833
52402 - Adenine nucleotide alpha hydrolases-like
52833 - Thioredoxin-like | 0 | DIRECT |
51905,51971
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
53720,56796
53720 - ALDH-like
56796 - Dehydroquinate synthase-like | 0 | DIRECT |
51730,53720
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | DIRECT |
51971,51905
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51395,51971
51395 - FMN-linked oxidoreductases
51971 - Nucleotide-binding domain | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
48695,51905
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
55856,56524
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain | 0 | DIRECT |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
47598,81935
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein | 0 | DIRECT |
51395,56014
51395 - FMN-linked oxidoreductases
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,53659
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
57802,49367
57802 - Rubredoxin-like
49367 - Superoxide reductase-like | 0 | DIRECT |
49764,63380
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
54631,51412
54631 - CBS-domain pair
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
56425,46977
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
50486,47336
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | DIRECT |
48179,55021
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
52518,54862
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
53323,52518
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
51604,56014
51604 - Enolase C-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
55347,69055
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
48050,48056
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain | 0 | DIRECT |
52833,51905
52833 - Thioredoxin-like
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
56014,50022
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | DIRECT |
51412,51412
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
142984,140490
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | DIRECT |
52922,52518
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
81296,55856
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
51717,56014
51717 - Dihydropteroate synthetase-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
51735,69075
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
46609,54719
46609 - Fe,Mn superoxide dismutase (SOD), N-terminal domain
54719 - Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
53633,53720
53633 - Carbamate kinase-like
53720 - ALDH-like | 0 | DIRECT |
54862,53706
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52833,57889
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
48264,52218
48264 - Cytochrome P450
52218 - Flavoproteins | 0 | DIRECT |
55856,63380
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
48056,81296
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | DIRECT |
46548,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain | 0 | DIRECT |
54862,53920
54862 - 4Fe-4S ferredoxins
53920 - Fe-only hydrogenase | 0 | DIRECT |
51735,55021
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | DIRECT |
50998,46626
50998 - Quinoprotein alcohol dehydrogenase-like
46626 - Cytochrome c | 0 | DIRECT |
56512,52218
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins | 0 | DIRECT |
81558,-9
81558 - Photosystem I subunits PsaA/PsaB
-9 - PDB | 0 | DIRECT |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | DIRECT |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
47240,-9
47240 - Ferritin-like
-9 - PDB | 0 | DIRECT |
54862,48371
54862 - 4Fe-4S ferredoxins
48371 - ARM repeat | 0 | DIRECT |
81558,81558
81558 - Photosystem I subunits PsaA/PsaB
81558 - Photosystem I subunits PsaA/PsaB | 0 | DIRECT |
49503,46626
49503 - Cupredoxins
46626 - Cytochrome c | 0 | DIRECT |
51395,54862
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
56176,56194
56176 - FAD-binding/transporter-associated domain-like
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
51905,52833
51905 - FAD/NAD(P)-binding domain
52833 - Thioredoxin-like | 0 | DIRECT |
53383,53383
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 0 | DIRECT |
55008,51905
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
57196,48113
57196 - EGF/Laminin
48113 - Heme-dependent peroxidases | 0 | DIRECT |
48113,48113
48113 - Heme-dependent peroxidases
48113 - Heme-dependent peroxidases | 0 | DIRECT |
48179,52413
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
51905,54862
51905 - FAD/NAD(P)-binding domain
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
54416,54416
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | DIRECT |
51412,56014
51412 - Inosine monophosphate dehydrogenase (IMPDH)
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
56014,55124
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
51905,47576
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
51366,56014
51366 - Ribulose-phoshate binding barrel
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
53706,50692
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | DIRECT |
52833,55068
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase | 0 | DIRECT |
50022,55961
50022 - ISP domain
55961 - Bet v1-like | 0 | DIRECT |
51905,47473
51905 - FAD/NAD(P)-binding domain
47473 - EF-hand | 0 | DIRECT |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | DIRECT |
52218,63380
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
53323,54862
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
56228,48310
56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain
48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
48113,-9
48113 - Heme-dependent peroxidases
-9 - PDB | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
46458,63380
46458 - Globin-like
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55856,51395
55856 - Cytochrome b5-like heme/steroid binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
51182,52833
51182 - RmlC-like cupins
52833 - Thioredoxin-like | 0 | DIRECT |
51971,51971
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
55035,56542
55035 - NAD-binding domain of HMG-CoA reductase
56542 - Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
51735,143548
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | DIRECT |
54292,54862
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
55021,51735
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
81442,81464
81442 - Cytochrome c oxidase subunit I-like
81464 - Cytochrome c oxidase subunit II-like, transmembrane region | 0 | DIRECT |
48452,51197
48452 - TPR-like
51197 - Clavaminate synthase-like | 0 | DIRECT |
52518,52218
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52218 - Flavoproteins | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
53597,55831
53597 - Dihydrofolate reductase-like
55831 - Thymidylate synthase/dCMP hydroxymethylase | 0 | DIRECT |
56821,46548
56821 - Prismane protein-like
46548 - alpha-helical ferredoxin | 0 | DIRECT |
55856,49764
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones | 0 | DIRECT |
55608,51998
55608 - Homing endonucleases
51998 - PFL-like glycyl radical enzymes | 0 | DIRECT |
81935,51730
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | DIRECT |
50965,81296
50965 - Galactose oxidase, central domain
81296 - E set domains | 0 | DIRECT |
50974,49503
50974 - Nitrous oxide reductase, N-terminal domain
49503 - Cupredoxins | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
81464,49503
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins | 0 | DIRECT |
54862,56014
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
52343,54292
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
54292 - 2Fe-2S ferredoxin-like | 0 | DIRECT |
69336,50692
69336 - Alpha subunit of glutamate synthase, C-terminal domain
50692 - ADC-like | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.000000000000003156 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.0000000000000153 | DIRECT |
53927,53597
53927 - Cytidine deaminase-like
53597 - Dihydrofolate reductase-like | 0.0000000000002216 | DIRECT |
143548,55021
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0.000000003461 | DIRECT |
46626,46626
46626 - Cytochrome c
46626 - Cytochrome c | 0.00001691 | DIRECT |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.00001786 | DIRECT |
53659,53659
53659 - Isocitrate/Isopropylmalate dehydrogenase-like
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0.00005304 | DIRECT |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.00008384 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0008799 | DIRECT |
54292,63380
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like | 0.0009006 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.002273 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || (3R)-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.002881 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || With an iron-sulfur protein as acceptor || With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) |
53633,55021
53633 - Carbamate kinase-like
55021 - ACT-like | 0.005507 | INHERITED FROM: Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.01115 | INHERITED FROM: L-2-aminoadipate reductase || Acting on the aldehyde or oxo group of donors || L-aminoadipate-semialdehyde dehydrogenase || With NAD(+) or NADP(+) as acceptor |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0.03011 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.04424 | INHERITED FROM: (3R)-hydroxyacyl-CoA dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.07406 | INHERITED FROM: Acting on the aldehyde or oxo group of donors || Oxoglutarate dehydrogenase (succinyl-transferring) || With a disulfide as acceptor |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1896 | INHERITED FROM: Protein-disulfide reductase || Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.3784 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0.758 | INHERITED FROM: Histidinol dehydrogenase |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.9301 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 1 | INHERITED FROM: With an iron-sulfur protein as acceptor || 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Thymine dioxygenase |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 1 | INHERITED FROM: Formyltetrahydrofolate dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating) |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 1 | INHERITED FROM: With a flavin as acceptor || With oxygen as acceptor || Acting on the CH-NH group of donors |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | INHERITED FROM: With disulfide as acceptor || Acting on phosphorus or arsenic in donors || With a quinone or similar compound as acceptor || Acting on a sulfur group of donors || Methylarsonate reductase || Glutathione dehydrogenase (ascorbate) |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48168,51998
48168 - R1 subunit of ribonucleotide reductase, N-terminal domain
51998 - PFL-like glycyl radical enzymes | 0 | Direct |
55447,54665
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
48179,54637
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
55383,54416
55383 - Copper amine oxidase, domain N
54416 - Amine oxidase N-terminal region | 0 | Direct |
50022,56281
50022 - ISP domain
56281 - Metallo-hydrolase/oxidoreductase | 0 | Direct |
54862,52518
54862 - 4Fe-4S ferredoxins
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
56524,81296
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
51905,51905
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
55347,55021
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
55124,54862
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins | 0 | Direct |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
46626,51004
46626 - Cytochrome c
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0 | Direct |
47336,53720
47336 - ACP-like
53720 - ALDH-like | 0 | Direct |
52922,53323
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
54416,49998
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | Direct |
49503,-7
49503 - Cupredoxins
-7 - CATH | 0 | Direct |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
56634,52317
56634 - Heme-dependent catalase-like
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
69742,51735
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
55124,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
51971,51395
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
51182,51182
51182 - RmlC-like cupins
51182 - RmlC-like cupins | 0 | Direct |
55068,51316
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | Direct |
75625,51998
75625 - YebC-like
51998 - PFL-like glycyl radical enzymes | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
142019,142984
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
56176,55447
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | Direct |
54862,51395
54862 - 4Fe-4S ferredoxins
51395 - FMN-linked oxidoreductases | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
47576,57716
47576 - Calponin-homology domain, CH-domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
54292,46548
54292 - 2Fe-2S ferredoxin-like
46548 - alpha-helical ferredoxin | 0 | Direct |
52402,52833
52402 - Adenine nucleotide alpha hydrolases-like
52833 - Thioredoxin-like | 0 | Direct |
51905,51971
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
53720,56796
53720 - ALDH-like
56796 - Dehydroquinate synthase-like | 0 | Direct |
51730,53720
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | Direct |
51971,51905
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51395,51971
51395 - FMN-linked oxidoreductases
51971 - Nucleotide-binding domain | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
48695,51905
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
55856,56524
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain | 0 | Direct |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
47598,81935
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein | 0 | Direct |
51395,56014
51395 - FMN-linked oxidoreductases
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,53659
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
57802,49367
57802 - Rubredoxin-like
49367 - Superoxide reductase-like | 0 | Direct |
49764,63380
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | Direct |
54631,51412
54631 - CBS-domain pair
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
56425,46977
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
50486,47336
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | Direct |
48179,55021
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
52518,54862
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | Direct |
53323,52518
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
51604,56014
51604 - Enolase C-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
55347,69055
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
48050,48056
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain | 0 | Direct |
52833,51905
52833 - Thioredoxin-like
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
56014,50022
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | Direct |
51412,51412
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
142984,140490
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | Direct |
52922,52518
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
81296,55856
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
51717,56014
51717 - Dihydropteroate synthetase-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
51735,69075
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
46609,54719
46609 - Fe,Mn superoxide dismutase (SOD), N-terminal domain
54719 - Fe,Mn superoxide dismutase (SOD), C-terminal domain | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
53633,53720
53633 - Carbamate kinase-like
53720 - ALDH-like | 0 | Direct |
54862,53706
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
52833,57889
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
48264,52218
48264 - Cytochrome P450
52218 - Flavoproteins | 0 | Direct |
55856,63380
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | Direct |
48056,81296
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | Direct |
46548,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain | 0 | Direct |
54862,53920
54862 - 4Fe-4S ferredoxins
53920 - Fe-only hydrogenase | 0 | Direct |
51735,55021
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | Direct |
50998,46626
50998 - Quinoprotein alcohol dehydrogenase-like
46626 - Cytochrome c | 0 | Direct |
56512,52218
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins | 0 | Direct |
81558,-9
81558 - Photosystem I subunits PsaA/PsaB
-9 - PDB | 0 | Direct |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | Direct |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
47240,-9
47240 - Ferritin-like
-9 - PDB | 0 | Direct |
54862,48371
54862 - 4Fe-4S ferredoxins
48371 - ARM repeat | 0 | Direct |
81558,81558
81558 - Photosystem I subunits PsaA/PsaB
81558 - Photosystem I subunits PsaA/PsaB | 0 | Direct |
49503,46626
49503 - Cupredoxins
46626 - Cytochrome c | 0 | Direct |
51395,54862
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | Direct |
56176,56194
56176 - FAD-binding/transporter-associated domain-like
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
51905,52833
51905 - FAD/NAD(P)-binding domain
52833 - Thioredoxin-like | 0 | Direct |
53383,53383
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 0 | Direct |
55008,51905
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
57196,48113
57196 - EGF/Laminin
48113 - Heme-dependent peroxidases | 0 | Direct |
48113,48113
48113 - Heme-dependent peroxidases
48113 - Heme-dependent peroxidases | 0 | Direct |
48179,52413
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
51905,54862
51905 - FAD/NAD(P)-binding domain
54862 - 4Fe-4S ferredoxins | 0 | Direct |
54416,54416
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | Direct |
51412,56014
51412 - Inosine monophosphate dehydrogenase (IMPDH)
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
56014,55124
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
51905,47576
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
51366,56014
51366 - Ribulose-phoshate binding barrel
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
53706,50692
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | Direct |
52833,55068
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase | 0 | Direct |
50022,55961
50022 - ISP domain
55961 - Bet v1-like | 0 | Direct |
51905,47473
51905 - FAD/NAD(P)-binding domain
47473 - EF-hand | 0 | Direct |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | Direct |
52218,63380
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | Direct |
53323,54862
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
54862 - 4Fe-4S ferredoxins | 0 | Direct |
56228,48310
56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain
48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
48113,-9
48113 - Heme-dependent peroxidases
-9 - PDB | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
46458,63380
46458 - Globin-like
63380 - Riboflavin synthase domain-like | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55856,51395
55856 - Cytochrome b5-like heme/steroid binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
51182,52833
51182 - RmlC-like cupins
52833 - Thioredoxin-like | 0 | Direct |
51971,51971
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
55035,56542
55035 - NAD-binding domain of HMG-CoA reductase
56542 - Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
51735,143548
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | Direct |
54292,54862
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins | 0 | Direct |
55021,51735
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
81442,81464
81442 - Cytochrome c oxidase subunit I-like
81464 - Cytochrome c oxidase subunit II-like, transmembrane region | 0 | Direct |
48452,51197
48452 - TPR-like
51197 - Clavaminate synthase-like | 0 | Direct |
52518,52218
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52218 - Flavoproteins | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
53597,55831
53597 - Dihydrofolate reductase-like
55831 - Thymidylate synthase/dCMP hydroxymethylase | 0 | Direct |
56821,46548
56821 - Prismane protein-like
46548 - alpha-helical ferredoxin | 0 | Direct |
55856,49764
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones | 0 | Direct |
55608,51998
55608 - Homing endonucleases
51998 - PFL-like glycyl radical enzymes | 0 | Direct |
81935,51730
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | Direct |
50965,81296
50965 - Galactose oxidase, central domain
81296 - E set domains | 0 | Direct |
50974,49503
50974 - Nitrous oxide reductase, N-terminal domain
49503 - Cupredoxins | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
81464,49503
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins | 0 | Direct |
54862,56014
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
52343,54292
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
54292 - 2Fe-2S ferredoxin-like | 0 | Direct |
69336,50692
69336 - Alpha subunit of glutamate synthase, C-terminal domain
50692 - ADC-like | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.000000000000003156 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.0000000000000153 | Direct |
53927,53597
53927 - Cytidine deaminase-like
53597 - Dihydrofolate reductase-like | 0.0000000000002216 | Direct |
143548,55021
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0.000000003461 | Direct |
46626,46626
46626 - Cytochrome c
46626 - Cytochrome c | 0.00001691 | Direct |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.00001786 | Direct |
53659,53659
53659 - Isocitrate/Isopropylmalate dehydrogenase-like
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0.00005304 | Direct |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.00008384 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0008799 | Direct |
54292,63380
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like | 0.0009006 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.002273 | Inherited |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.002881 | Inherited |
53633,55021
53633 - Carbamate kinase-like
55021 - ACT-like | 0.005507 | Inherited |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.01115 | Inherited |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0.03011 | Inherited |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.04424 | Inherited |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.07406 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1896 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.3784 | Inherited |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0.758 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.9301 | Inherited |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 1 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 1 | Inherited |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 1 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | Inherited |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 1 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56176,55447,54665
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
81296,55856,63380
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
51905,56425,46977
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
51971,51905,51971
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
51905,51905,55424
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
81935,51730,53720
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | DIRECT |
51971,51905,55424
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
55124,56014,55124
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | DIRECT |
52283,51735,143548
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | DIRECT |
48264,52218,63380
48264 - Cytochrome P450
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
51735,48179,55021
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | DIRECT |
46548,51971,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | DIRECT |
55124,54862,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
55383,54416,54416
55383 - Copper amine oxidase, domain N
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
49764,63380,52343
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
47741,56176,55447
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | DIRECT |
55124,56014,50022
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
81464,49503,46626
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins
46626 - Cytochrome c | 0 | DIRECT |
51735,48179,54637
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
56014,55124,56014
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | DIRECT |
47598,81935,51730
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | DIRECT |
52833,52833,57889
52833 - Thioredoxin-like
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
48695,51905,56425
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
55856,49764,63380
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
51395,51971,51905
51395 - FMN-linked oxidoreductases
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
55447,54665,56003
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
52518,52922,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0 | DIRECT |
52518,52922,53323
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | DIRECT |
56512,52218,63380
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | DIRECT |
55021,51735,55347
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
48050,48056,81296
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54292,54862,53706
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
63380,52343,54292
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
54292 - 2Fe-2S ferredoxin-like | 0 | DIRECT |
52922,52518,54862
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
51735,55347,69055
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
46626,46626,46626
46626 - Cytochrome c
46626 - Cytochrome c
46626 - Cytochrome c | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,55347,55021
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | DIRECT |
55021,55021,51735
55021 - ACT-like
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
50486,47336,53720
50486 - FMT C-terminal domain-like
47336 - ACP-like
53720 - ALDH-like | 0 | DIRECT |
54416,54416,49998
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | DIRECT |
81558,81558,-9
81558 - Photosystem I subunits PsaA/PsaB
81558 - Photosystem I subunits PsaA/PsaB
-9 - PDB | 0 | DIRECT |
52833,55068,51316
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | DIRECT |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
142019,142984,140490
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | DIRECT |
55008,51905,55424
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53328,50486,47336
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | DIRECT |
52218,63380,52343
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
69742,51735,69075
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | DIRECT |
55856,56524,81296
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | DIRECT |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
54862,53706,50692
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | DIRECT |
52283,51735,55021
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51971,51971,51395
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
53223,51735,53659
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
51905,47576,57716
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
51971,51395,54862
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
53323,54862,52518
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
54862 - 4Fe-4S ferredoxins
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
51905,51905,47473
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain
47473 - EF-hand | 0 | DIRECT |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
51735,48179,52413
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
48113,48113,-9
48113 - Heme-dependent peroxidases
48113 - Heme-dependent peroxidases
-9 - PDB | 0 | DIRECT |
46458,63380,52343
46458 - Globin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
53323,52518,52922
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
56524,81296,55856
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
47576,57716,57716
47576 - Calponin-homology domain, CH-domain
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
51735,143548,55021
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
55856,63380,52343
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
52922,53323,54862
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000007245 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0.0003872 | DIRECT |
54292,63380,52343
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0009006 | DIRECT |
53633,55021,55021
53633 - Carbamate kinase-like
55021 - ACT-like
55021 - ACT-like | 0.005507 | INHERITED FROM: Homoserine dehydrogenase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.02159 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || Acting on the CH-OH group of donors || With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.02367 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.2989 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Acting on the CH-CH group of donors || 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.7826 | INHERITED FROM: Protein-disulfide reductase || Acting on a sulfur group of donors || With NAD(+) or NADP(+) as acceptor |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: Acting on a peroxide as acceptor || Peroxidases || Peroxidase |
52518,52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 1 | INHERITED FROM: With a disulfide as acceptor || Pyruvate dehydrogenase (acetyl-transferring) |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56176,55447,54665
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
81296,55856,63380
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like | 0 | Direct |
51905,56425,46977
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
51971,51905,51971
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
51905,51905,55424
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
81935,51730,53720
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase
53720 - ALDH-like | 0 | Direct |
51971,51905,55424
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
55124,56014,55124
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like | 0 | Direct |
52283,51735,143548
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | Direct |
48264,52218,63380
48264 - Cytochrome P450
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | Direct |
51735,48179,55021
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | Direct |
46548,51971,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0 | Direct |
55124,54862,56014
55124 - Nitrite/Sulfite reductase N-terminal domain-like
54862 - 4Fe-4S ferredoxins
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
55383,54416,54416
55383 - Copper amine oxidase, domain N
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
49764,63380,52343
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
47741,56176,55447
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like
55447 - CO dehydrogenase flavoprotein C-terminal domain-like | 0 | Direct |
55124,56014,50022
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
50022 - ISP domain | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
81464,49503,46626
81464 - Cytochrome c oxidase subunit II-like, transmembrane region
49503 - Cupredoxins
46626 - Cytochrome c | 0 | Direct |
51735,48179,54637
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
56014,55124,56014
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55124 - Nitrite/Sulfite reductase N-terminal domain-like
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like | 0 | Direct |
47598,81935,51730
47598 - Ribbon-helix-helix
81935 - N-terminal domain of bifunctional PutA protein
51730 - FAD-linked oxidoreductase | 0 | Direct |
52833,52833,57889
52833 - Thioredoxin-like
52833 - Thioredoxin-like
57889 - Cysteine-rich domain | 0 | Direct |
48695,51905,56425
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
55856,49764,63380
55856 - Cytochrome b5-like heme/steroid binding domain
49764 - HSP20-like chaperones
63380 - Riboflavin synthase domain-like | 0 | Direct |
51395,51971,51905
51395 - FMN-linked oxidoreductases
51971 - Nucleotide-binding domain
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
55447,54665,56003
55447 - CO dehydrogenase flavoprotein C-terminal domain-like
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
52518,52922,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0 | Direct |
52518,52922,53323
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0 | Direct |
56512,52218,63380
56512 - Nitric oxide (NO) synthase oxygenase domain
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like | 0 | Direct |
55021,51735,55347
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
48050,48056,81296
48050 - Hemocyanin, N-terminal domain
48056 - Di-copper centre-containing domain
81296 - E set domains | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54292,54862,53706
54292 - 2Fe-2S ferredoxin-like
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
63380,52343,54292
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
54292 - 2Fe-2S ferredoxin-like | 0 | Direct |
52922,52518,54862
52922 - TK C-terminal domain-like
52518 - Thiamin diphosphate-binding fold (THDP-binding)
54862 - 4Fe-4S ferredoxins | 0 | Direct |
51735,55347,69055
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
46626,46626,46626
46626 - Cytochrome c
46626 - Cytochrome c
46626 - Cytochrome c | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,55347,55021
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | Direct |
55021,55021,51735
55021 - ACT-like
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
50486,47336,53720
50486 - FMT C-terminal domain-like
47336 - ACP-like
53720 - ALDH-like | 0 | Direct |
54416,54416,49998
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | Direct |
81558,81558,-9
81558 - Photosystem I subunits PsaA/PsaB
81558 - Photosystem I subunits PsaA/PsaB
-9 - PDB | 0 | Direct |
52833,55068,51316
52833 - Thioredoxin-like
55068 - Peptide methionine sulfoxide reductase
51316 - Mss4-like | 0 | Direct |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
142019,142984,140490
142019 - Nqo1 FMN-binding domain-like
142984 - Nqo1 middle domain-like
140490 - Nqo1C-terminal domain-like | 0 | Direct |
55008,51905,55424
55008 - HMA, heavy metal-associated domain
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53328,50486,47336
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
47336 - ACP-like | 0 | Direct |
52218,63380,52343
52218 - Flavoproteins
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
69742,51735,69075
69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
69075 - Glutamyl tRNA-reductase dimerization domain | 0 | Direct |
55856,56524,81296
55856 - Cytochrome b5-like heme/steroid binding domain
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains | 0 | Direct |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
54862,53706,50692
54862 - 4Fe-4S ferredoxins
53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
50692 - ADC-like | 0 | Direct |
52283,51735,55021
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51971,51971,51395
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
53223,51735,53659
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
51905,47576,57716
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
51971,51395,54862
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | Direct |
53323,54862,52518
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
54862 - 4Fe-4S ferredoxins
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
51905,51905,47473
51905 - FAD/NAD(P)-binding domain
51905 - FAD/NAD(P)-binding domain
47473 - EF-hand | 0 | Direct |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
51735,48179,52413
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
48113,48113,-9
48113 - Heme-dependent peroxidases
48113 - Heme-dependent peroxidases
-9 - PDB | 0 | Direct |
46458,63380,52343
46458 - Globin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
53323,52518,52922
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
56524,81296,55856
56524 - Oxidoreductase molybdopterin-binding domain
81296 - E set domains
55856 - Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
47576,57716,57716
47576 - Calponin-homology domain, CH-domain
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
51735,143548,55021
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | Direct |
55856,63380,52343
55856 - Cytochrome b5-like heme/steroid binding domain
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
52922,53323,54862
52922 - TK C-terminal domain-like
53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
54862 - 4Fe-4S ferredoxins | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000007245 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0.0003872 | Direct |
54292,63380,52343
54292 - 2Fe-2S ferredoxin-like
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0009006 | Direct |
53633,55021,55021
53633 - Carbamate kinase-like
55021 - ACT-like
55021 - ACT-like | 0.005507 | Inherited |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.02159 | Inherited |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.02367 | Inherited |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.2989 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.7826 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
52518,52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
