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Enzyme Commission (EC): Acting on the CH-OH group of donors
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Serine metabolism enzymes domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0.000000000000003519 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.00000000000001533 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0.0000000000001724 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.00000000004223 | DIRECT |
| FMT C-terminal domain-like | 0.0000000004639 | DIRECT |
| Formyltransferase | 0.000000001517 | DIRECT |
| SCP-like | 0.00002148 | DIRECT |
| FMN-dependent nitroreductase-like | 0.0009191 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0.001324 | INHERITED FROM: D-lactate dehydrogenase (quinone) || With other acceptors || D-2-hydroxyglutarate dehydrogenase || D-lactate dehydrogenase (cytochrome) || With a cytochrome as acceptor |
| EPT/RTPC-like | 0.001725 | INHERITED FROM: Shikimate dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| ACT-like | 0.00256 | INHERITED FROM: 2-oxoglutarate reductase || Homoserine dehydrogenase || With NAD(+) or NADP(+) as acceptor || Phosphoglycerate dehydrogenase |
| FabD/lysophospholipase-like | 0.01328 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Cytochrome c | 0.02338 | INHERITED FROM: With a quinone or similar compound as acceptor || With a copper protein as acceptor || With a cytochrome as acceptor || Alcohol dehydrogenase (quinone) |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.03763 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.06691 | INHERITED FROM: D-xylose 1-dehydrogenase (NADP(+)) || Homoserine dehydrogenase || Inositol 2-dehydrogenase || 1-deoxy-D-xylulose-5-phosphate reductoisomerase || With NAD(+) or NADP(+) as acceptor || Glucose-6-phosphate dehydrogenase (NADP(+)) || D-chiro-inositol 1-dehydrogenase || dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| Inosine monophosphate dehydrogenase (IMPDH) | 0.2291 | INHERITED FROM: IMP dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| ACP-like | 0.3693 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Dihydrofolate reductase-like | 0.6963 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase || 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| EF-hand | 0.9756 | INHERITED FROM: With a quinone or similar compound as acceptor || Glycerol-3-phosphate dehydrogenase |
| Bacterial luciferase-like | 1 | INHERITED FROM: With other, known, acceptors || Glucose-6-phosphate dehydrogenase (coenzyme-F420) |
| ALDH-like | 1 | INHERITED FROM: Histidinol dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| FMN-linked oxidoreductases | 1 | INHERITED FROM: (S)-2-hydroxy-acid oxidase || With oxygen as acceptor |
| all-alpha NTP pyrophosphatases | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | INHERITED FROM: Carnitine 3-dehydrogenase || (3R)-hydroxyacyl-CoA dehydrogenase |
| Thiolase-like | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| 4'-phosphopantetheinyl transferase | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: With other acceptors || With a quinone or similar compound as acceptor || Choline dehydrogenase || With oxygen as acceptor |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| Aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| PFL-like glycyl radical enzymes | 1 | INHERITED FROM: Ribonucleoside-triphosphate reductase (formate) || With other, known, acceptors |
| Cytidine deaminase-like | 1 | INHERITED FROM: 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Shikimate dehydrogenase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase (NAD(P)(+)) || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| FAD-binding/transporter-associated domain-like | 1 | INHERITED FROM: D-lactate dehydrogenase (quinone) || With other acceptors || D-2-hydroxyglutarate dehydrogenase || D-lactate dehydrogenase (cytochrome) || With a cytochrome as acceptor || L-gulonolactone oxidase || D-arabinono-1,4-lactone oxidase || With oxygen as acceptor |
| Carbamate kinase-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HCDH C-domain-like | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain | 0 | DIRECT |
| Monomeric isocitrate dehydrogenase | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| RibD C-terminal domain-like | 0 | DIRECT |
| D-lactate dehydrogenase | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Iron-containing alcohol dehydrogenase | 0 | DIRECT |
| Mannitol 2-dehydrogenase | 0 | DIRECT |
| Shikimate kinase (AroK) | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| Glycerol-3-phosphate dehydrogenase | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| L-histidinol dehydrogenase HisD | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase dimerisation domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase, C-terminal domain | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| Tyrosine-dependent oxidoreductases | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Ketopantoate reductase PanE | 0 | DIRECT |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| Aldo-keto reductases (NADP) | 0 | DIRECT |
| Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) | 0 | DIRECT |
| SerA intervening domain-like | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | DIRECT |
| Dihydrodipicolinate reductase-like | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Glucose 6-phosphate dehydrogenase-like | 0 | DIRECT |
| Class III anaerobic ribonucleotide reductase NRDD subunit | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| GMC oxidoreductases | 0 | DIRECT |
| Shikimate dehydrogenase-like | 0 | DIRECT |
| PdxA-like | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0.000000000000004897 | DIRECT |
| Dehydroquinate synthase, DHQS | 0.000000000000007958 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.00000000000002368 | DIRECT |
| Post formyltransferase domain | 0.0000000007066 | DIRECT |
| Homoserine dehydrogenase-like | 0.000000003406 | DIRECT |
| Formyltransferase | 0.00000000341 | DIRECT |
| Deoxycytidylate deaminase-like | 0.000000007221 | DIRECT |
| Aspartokinase allosteric domain-like | 0.00000001559 | DIRECT |
| Acyl-carrier protein (ACP) | 0.00000002572 | DIRECT |
| FAD-linked oxidases, N-terminal domain | 0.0000001381 | DIRECT |
| F420 dependent oxidoreductases | 0.0000004469 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00001309 | DIRECT |
| Sterol carrier protein, SCP | 0.00002009 | DIRECT |
| FabD-like | 0.0003166 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0.000331 | DIRECT |
| Enolpyruvate transferase, EPT | 0.0004295 | DIRECT |
| NADH oxidase/flavin reductase | 0.0007104 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0.0008905 | DIRECT |
| Phosphotransacetylase | 0.003317 | INHERITED FROM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) |
| MaoC-like | 0.02432 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || (3R)-hydroxyacyl-CoA dehydrogenase |
| 4HBT-like | 0.02993 | INHERITED FROM: Carnitine 3-dehydrogenase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.05848 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Inosine monophosphate dehydrogenase (IMPDH) | 0.1636 | INHERITED FROM: IMP dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| Thiolase-related | 0.1787 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Class I aldolase | 0.1893 | INHERITED FROM: Shikimate dehydrogenase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0.1894 | INHERITED FROM: D-xylose 1-dehydrogenase (NADP(+)) || Homoserine dehydrogenase || Inositol 2-dehydrogenase || 1-deoxy-D-xylulose-5-phosphate reductoisomerase || With NAD(+) or NADP(+) as acceptor || Glucose-6-phosphate dehydrogenase (NADP(+)) || D-chiro-inositol 1-dehydrogenase || dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| PyrH-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
| FMN-linked oxidoreductases | 1 | INHERITED FROM: (S)-2-hydroxy-acid oxidase || With oxygen as acceptor |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| NagB-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase (NAD(P)(+)) || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| Holo-(acyl carrier protein) synthase ACPS | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| HisE-like (PRA-PH) | 1 | INHERITED FROM: Histidinol dehydrogenase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HCDH C-domain-like | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain | 0 | Direct |
| Monomeric isocitrate dehydrogenase | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| RibD C-terminal domain-like | 0 | Direct |
| D-lactate dehydrogenase | 0 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Iron-containing alcohol dehydrogenase | 0 | Direct |
| Mannitol 2-dehydrogenase | 0 | Direct |
| Shikimate kinase (AroK) | 0 | Direct |
| Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
| Methanol dehydrogenase subunit | 0 | Direct |
| Glycerol-3-phosphate dehydrogenase | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
| L-histidinol dehydrogenase HisD | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase dimerisation domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase, C-terminal domain | 0 | Direct |
| NAD-binding domain of HMG-CoA reductase | 0 | Direct |
| Tyrosine-dependent oxidoreductases | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Ketopantoate reductase PanE | 0 | Direct |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Crotonase-like | 0 | Direct |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
| Aldo-keto reductases (NADP) | 0 | Direct |
| Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) | 0 | Direct |
| SerA intervening domain-like | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | Direct |
| Dihydrodipicolinate reductase-like | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Glucose 6-phosphate dehydrogenase-like | 0 | Direct |
| Class III anaerobic ribonucleotide reductase NRDD subunit | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| GMC oxidoreductases | 0 | Direct |
| Shikimate dehydrogenase-like | 0 | Direct |
| PdxA-like | 0 | Direct |
| L-sulfolactate dehydrogenase-like | 0.000000000000004897 | Direct |
| Dehydroquinate synthase, DHQS | 0.000000000000007958 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0.00000000000002368 | Direct |
| Post formyltransferase domain | 0.0000000007066 | Direct |
| Homoserine dehydrogenase-like | 0.000000003406 | Direct |
| Formyltransferase | 0.00000000341 | Direct |
| Deoxycytidylate deaminase-like | 0.000000007221 | Direct |
| Aspartokinase allosteric domain-like | 0.00000001559 | Direct |
| Acyl-carrier protein (ACP) | 0.00000002572 | Direct |
| FAD-linked oxidases, N-terminal domain | 0.0000001381 | Direct |
| F420 dependent oxidoreductases | 0.0000004469 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00001309 | Direct |
| Sterol carrier protein, SCP | 0.00002009 | Direct |
| FabD-like | 0.0003166 | Direct |
| FAD-linked reductases, N-terminal domain | 0.000331 | Direct |
| Enolpyruvate transferase, EPT | 0.0004295 | Direct |
| NADH oxidase/flavin reductase | 0.0007104 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0.0008905 | Direct |
| Phosphotransacetylase | 0.003317 | Inherited |
| MaoC-like | 0.02432 | Inherited |
| 4HBT-like | 0.02993 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.05848 | Inherited |
| Inosine monophosphate dehydrogenase (IMPDH) | 0.1636 | Inherited |
| Thiolase-related | 0.1787 | Inherited |
| Class I aldolase | 0.1893 | Inherited |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0.1894 | Inherited |
| PyrH-like | 1 | Inherited |
| FMN-linked oxidoreductases | 1 | Inherited |
| HisI-like | 1 | Inherited |
| NagB-like | 1 | Inherited |
| Holo-(acyl carrier protein) synthase ACPS | 1 | Inherited |
| HisE-like (PRA-PH) | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Methanol dehydrogenase subunit | 0 | DIRECT |
| Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
| NAD(P)-linked oxidoreductase | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| NAD-binding domain of HMG-CoA reductase | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
| Serine metabolism enzymes domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| L-sulfolactate dehydrogenase-like | 0.00000000000000246 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0.00000000000001079 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0.0000000000001224 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.00000000003081 | DIRECT |
| FMT C-terminal domain-like | 0.0000000003437 | DIRECT |
| Formyltransferase | 0.000000001131 | DIRECT |
| SCP-like | 0.00001709 | DIRECT |
| FMN-dependent nitroreductase-like | 0.0007569 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0.001095 | INHERITED FROM: With other acceptors || D-2-hydroxyglutarate dehydrogenase || D-lactate dehydrogenase (quinone) || D-lactate dehydrogenase (cytochrome) || With a cytochrome as acceptor |
| EPT/RTPC-like | 0.001432 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Shikimate dehydrogenase |
| ACT-like | 0.002134 | INHERITED FROM: 2-oxoglutarate reductase || With NAD(+) or NADP(+) as acceptor || Homoserine dehydrogenase || Phosphoglycerate dehydrogenase |
| FabD/lysophospholipase-like | 0.01128 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Cytochrome c | 0.02001 | INHERITED FROM: With a quinone or similar compound as acceptor || With a copper protein as acceptor || Alcohol dehydrogenase (quinone) || With a cytochrome as acceptor |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.03236 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.05805 | INHERITED FROM: D-xylose 1-dehydrogenase (NADP(+)) || Glucose-6-phosphate dehydrogenase (NADP(+)) || dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase || D-chiro-inositol 1-dehydrogenase || With NAD(+) or NADP(+) as acceptor || Homoserine dehydrogenase || 1-deoxy-D-xylulose-5-phosphate reductoisomerase || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) || Inositol 2-dehydrogenase |
| Inosine monophosphate dehydrogenase (IMPDH) | 0.2038 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || IMP dehydrogenase |
| ACP-like | 0.3342 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Dihydrofolate reductase-like | 0.64 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase || 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| EF-hand | 0.9028 | INHERITED FROM: Glycerol-3-phosphate dehydrogenase || With a quinone or similar compound as acceptor |
| Cytidine deaminase-like | 0.957 | INHERITED FROM: 5-amino-6-(5-phosphoribosylamino)uracil reductase |
| 4'-phosphopantetheinyl transferase | 0.9812 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| all-alpha NTP pyrophosphatases | 0.9817 | INHERITED FROM: Histidinol dehydrogenase |
| HisI-like | 1 | INHERITED FROM: Histidinol dehydrogenase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Glucose 1-dehydrogenase (NAD(P)(+)) || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) |
| Aldolase | 1 | INHERITED FROM: Shikimate dehydrogenase |
| FMN-linked oxidoreductases | 1 | INHERITED FROM: With oxygen as acceptor || (S)-2-hydroxy-acid oxidase |
| Carbamate kinase-like | 1 | INHERITED FROM: Homoserine dehydrogenase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Shikimate dehydrogenase |
| Bacterial luciferase-like | 1 | INHERITED FROM: With other, known, acceptors || Glucose-6-phosphate dehydrogenase (coenzyme-F420) |
| FAD-binding/transporter-associated domain-like | 1 | INHERITED FROM: With other acceptors || D-2-hydroxyglutarate dehydrogenase || D-lactate dehydrogenase (quinone) || D-arabinono-1,4-lactone oxidase || L-gulonolactone oxidase || D-lactate dehydrogenase (cytochrome) || With oxygen as acceptor || With a cytochrome as acceptor |
| Thioesterase/thiol ester dehydrase-isomerase | 1 | INHERITED FROM: (3R)-hydroxyacyl-CoA dehydrogenase || Carnitine 3-dehydrogenase |
| ALDH-like | 1 | INHERITED FROM: Histidinol dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| Thiolase-like | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| PFL-like glycyl radical enzymes | 1 | INHERITED FROM: Ribonucleoside-triphosphate reductase (formate) || With other, known, acceptors |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: With other acceptors || With a quinone or similar compound as acceptor || Choline dehydrogenase || With oxygen as acceptor |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48179,54637
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
55347,55021
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
53720,56796
53720 - ALDH-like
56796 - Dehydroquinate synthase-like | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,53659
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
54631,51412
54631 - CBS-domain pair
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
55347,69055
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
51412,51412
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
51735,55021
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | DIRECT |
48179,52413
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55856,51395
55856 - Cytochrome b5-like heme/steroid binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
53927,53597
53927 - Cytidine deaminase-like
53597 - Dihydrofolate reductase-like | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
55035,56542
55035 - NAD-binding domain of HMG-CoA reductase
56542 - Substrate-binding domain of HMG-CoA reductase | 0 | DIRECT |
51735,143548
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | DIRECT |
55021,51735
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
143548,55021
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0.00000000000000246 | DIRECT |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 0.0000000001593 | DIRECT |
53633,55021
53633 - Carbamate kinase-like
55021 - ACT-like | 0.00000001487 | DIRECT |
53659,53659
53659 - Isocitrate/Isopropylmalate dehydrogenase-like
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0.00000008406 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0000005513 | DIRECT |
50998,46626
50998 - Quinoprotein alcohol dehydrogenase-like
46626 - Cytochrome c | 0.00001034 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.00001075 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0001018 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0.001095 | INHERITED FROM: With other acceptors || D-2-hydroxyglutarate dehydrogenase || D-lactate dehydrogenase (quinone) || D-lactate dehydrogenase (cytochrome) || With a cytochrome as acceptor |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.00205 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0.006855 | INHERITED FROM: Histidinol dehydrogenase |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.03236 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
55021,55021
55021 - ACT-like
55021 - ACT-like | 0.05251 | INHERITED FROM: Homoserine dehydrogenase |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.05901 | INHERITED FROM: D-xylose 1-dehydrogenase (NADP(+)) || Glucose-6-phosphate dehydrogenase (NADP(+)) || dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase || D-chiro-inositol 1-dehydrogenase || With NAD(+) or NADP(+) as acceptor || Homoserine dehydrogenase || 1-deoxy-D-xylulose-5-phosphate reductoisomerase || Glucose-6-phosphate dehydrogenase (NAD(P)(+)) || Inositol 2-dehydrogenase |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 1 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48179,54637
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
55347,55021
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | Direct |
53720,56796
53720 - ALDH-like
56796 - Dehydroquinate synthase-like | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,53659
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
54631,51412
54631 - CBS-domain pair
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
55347,69055
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
51412,51412
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
51735,55021
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | Direct |
48179,52413
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55856,51395
55856 - Cytochrome b5-like heme/steroid binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
53927,53597
53927 - Cytidine deaminase-like
53597 - Dihydrofolate reductase-like | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
55035,56542
55035 - NAD-binding domain of HMG-CoA reductase
56542 - Substrate-binding domain of HMG-CoA reductase | 0 | Direct |
51735,143548
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | Direct |
55021,51735
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
143548,55021
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0.00000000000000246 | Direct |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 0.0000000001593 | Direct |
53633,55021
53633 - Carbamate kinase-like
55021 - ACT-like | 0.00000001487 | Direct |
53659,53659
53659 - Isocitrate/Isopropylmalate dehydrogenase-like
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0.00000008406 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0000005513 | Direct |
50998,46626
50998 - Quinoprotein alcohol dehydrogenase-like
46626 - Cytochrome c | 0.00001034 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.00001075 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0001018 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0.001095 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.00205 | Inherited |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0.006855 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.03236 | Inherited |
55021,55021
55021 - ACT-like
55021 - ACT-like | 0.05251 | Inherited |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.05901 | Inherited |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
52283,51735,143548
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
51735,48179,54637
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
55021,51735,55347
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
51735,55347,69055
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,55347,55021
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | DIRECT |
55021,55021,51735
55021 - ACT-like
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
52283,51735,55021
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
53223,51735,53659
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
51735,48179,52413
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | DIRECT |
51735,143548,55021
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000003139 | DIRECT |
53633,55021,55021
53633 - Carbamate kinase-like
55021 - ACT-like
55021 - ACT-like | 0.00000001487 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00002488 | DIRECT |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.001287 | INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase || With NAD(+) or NADP(+) as acceptor |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
52283,51735,143548
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
51735,48179,54637
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
55021,51735,55347
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
51735,55347,69055
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,55347,55021
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55021 - ACT-like | 0 | Direct |
55021,55021,51735
55021 - ACT-like
55021 - ACT-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
52283,51735,55021
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains
55021 - ACT-like | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
53223,51735,53659
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains
53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
51735,48179,52413
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 0 | Direct |
51735,143548,55021
51735 - NAD(P)-binding Rossmann-fold domains
143548 - Serine metabolism enzymes domain
55021 - ACT-like | 0 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000003139 | Direct |
53633,55021,55021
53633 - Carbamate kinase-like
55021 - ACT-like
55021 - ACT-like | 0.00000001487 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00002488 | Direct |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.001287 | Inherited |
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A presence/absence matrix is generated using protein domains and supradomains
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