Enzyme Commission (EC): Acting on CH or CH(2) groups

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: root [root] <7>

+ 1: Oxidoreductases [1] <26> (213|314) (212|187|94)

0: Acting on CH or CH(2) groups [1.17] <10> (30|24) (29|23|8)

- 1: With NAD(+) or NADP(+) as acceptor [1.17.1] <11> (13|12) (13|10|6)

- 1: With other acceptors [1.17.99] <7> (5|2) (5|3|1)

- 1: With a disulfide as acceptor [1.17.4] <5> (7|5) (6|4|0)

- 1: With an iron-sulfur protein as acceptor [1.17.7] <4> (6|5) (6|6|1)

- 1: With oxygen as acceptor [1.17.3] <4> (6|6) (6|5|4)

- 1: With a cytochrome as acceptor [1.17.2] <3> (0|0) (0|0|0)

- 1: With a quinone or similar compound as acceptor [1.17.5] <3> (0|0) (0|0|0)

- 1: With other, known, acceptors [1.17.98] <3> (0|0) (0|0|0)

- 1: With a copper protein as acceptor [1.17.9] <1> (0|0) (0|0|0)

- 1: With a flavin as acceptor [1.17.8] <1> (1|0) (1|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Ferritin-like	0	Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	Direct
Dihydropteroate synthetase-like	0	Direct
R1 subunit of ribonucleotide reductase, N-terminal domain	0	Direct
Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
YebC-like	0	Direct
PFL-like glycyl radical enzymes	0	Direct
Molybdenum cofactor-binding domain	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	5.111e-16	Direct
CO dehydrogenase flavoprotein C-terminal domain-like	0.000000000000001017	Direct
Enolase C-terminal domain-like	0.000000000000001017	Direct
CO dehydrogenase ISP C-domain like	0.00000000000003293	Direct
2Fe-2S ferredoxin-like	0.0000000003217	Direct
NAD(P)-binding Rossmann-fold domains	0.0000000005037	Direct
alpha-helical ferredoxin	0.0000001701	Direct
Hedgehog/intein (Hint) domain	0.0000856	Direct
SCOP hierarchy in SUPERFAMILY	0.000131	Direct
Homing endonucleases	0.000262	Direct
4Fe-4S ferredoxins	0.0003167	Direct
ADC-like	0.001583	Inherited
Inosine monophosphate dehydrogenase (IMPDH)	0.001702	Inherited
Formate dehydrogenase/DMSO reductase, domains 1-3	0.004481	Inherited
ARM repeat	0.006195	Inherited
Formate/glycerate dehydrogenase catalytic domain-like	0.4411	Inherited
FAD-binding/transporter-associated domain-like	0.7762	Inherited
Acyl-CoA dehydrogenase NM domain-like	0.8403	Inherited
Acyl-CoA dehydrogenase C-terminal domain-like	0.8403	Inherited
Nucleic acid-binding proteins	1	Inherited
FMN-linked oxidoreductases	1	Inherited
FAD/NAD(P)-binding domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
R1 subunit of ribonucleotide reductase, C-terminal domain	0	Direct
Ribonucleotide reductase-like	0	Direct
B12-dependent (class II) ribonucleotide reductase	0	Direct
Dihydrodipicolinate reductase-like	0	Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	Direct
YebC-like	0	Direct
Molybdenum cofactor-binding domain	0	Direct
R1 subunit of ribonucleotide reductase, N-terminal domain	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	3.693e-16	Direct
CO dehydrogenase flavoprotein C-terminal domain-like	0.000000000000005616	Direct
CO dehydrogenase flavoprotein N-terminal domain-like	0.00000000000001369	Direct
CO dehydrogenase ISP C-domain like	0.0000000000000212	Direct
Dihydropteroate synthetase	0.00000000003482	Direct
2Fe-2S ferredoxin domains from multidomain proteins	0.000000007576	Direct
Formate dehydrogenase/DMSO reductase, C-terminal domain	0.001187	Inherited
Formate dehydrogenase/DMSO reductase, domains 1-3	0.004176	Inherited
D-glucarate dehydratase-like	0.03144	Inherited
acyl-CoA oxidase N-terminal domains	0.03329	Inherited
acyl-CoA oxidase C-terminal domains	0.03676	Inherited
Formate/glycerate dehydrogenases, substrate-binding domain	0.233	Inherited
Inosine monophosphate dehydrogenase (IMPDH)	0.2501	Inherited
Formate/glycerate dehydrogenases, NAD-domain	0.5411	Inherited
Cold shock DNA-binding domain-like	0.7345	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
YebC-like	0	Direct
R1 subunit of ribonucleotide reductase, N-terminal domain	0	Direct
Dihydropteroate synthetase-like	0	Direct
Molybdenum cofactor-binding domain	0	Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	Direct
Ferritin-like	0	Direct
PFL-like glycyl radical enzymes	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	3.548e-16	Direct
CO dehydrogenase flavoprotein C-terminal domain-like	7.073e-16	Direct
Enolase C-terminal domain-like	7.073e-16	Direct
CO dehydrogenase ISP C-domain like	0.00000000000002323	Direct
2Fe-2S ferredoxin-like	0.0000000002376	Direct
NAD(P)-binding Rossmann-fold domains	0.0000000003732	Direct
alpha-helical ferredoxin	0.0000001305	Direct
Hedgehog/intein (Hint) domain	0.00006889	Direct
Homing endonucleases	0.000213	Direct
4Fe-4S ferredoxins	0.0002579	Direct
ADC-like	0.001312	Inherited
Inosine monophosphate dehydrogenase (IMPDH)	0.001412	Inherited
Formate dehydrogenase/DMSO reductase, domains 1-3	0.003754	Inherited
ARM repeat	0.005213	Inherited
Formate/glycerate dehydrogenase catalytic domain-like	0.4011	Inherited
FAD-binding/transporter-associated domain-like	0.7143	Inherited
Acyl-CoA dehydrogenase C-terminal domain-like	0.7745	Inherited
Acyl-CoA dehydrogenase NM domain-like	0.7745	Inherited
FMN-linked oxidoreductases	1	Inherited
Nucleic acid-binding proteins	1	Inherited
FAD/NAD(P)-binding domain	1	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48168,51998 48168 - R1 subunit of ribonucleotide reductase, N-terminal domain 51998 - PFL-like glycyl radical enzymes	0	Direct
75625,51998 75625 - YebC-like 51998 - PFL-like glycyl radical enzymes	0	Direct
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	Direct
51395,56014 51395 - FMN-linked oxidoreductases 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
51604,56014 51604 - Enolase C-terminal domain-like 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
51717,56014 51717 - Dihydropteroate synthetase-like 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
47240,-9 47240 - Ferritin-like -9 - PDB	0	Direct
54862,48371 54862 - 4Fe-4S ferredoxins 48371 - ARM repeat	0	Direct
51412,56014 51412 - Inosine monophosphate dehydrogenase (IMPDH) 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
51366,56014 51366 - Ribulose-phoshate binding barrel 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
55608,51998 55608 - Homing endonucleases 51998 - PFL-like glycyl radical enzymes	0	Direct
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	3.548e-16	Direct
56176,55447 56176 - FAD-binding/transporter-associated domain-like 55447 - CO dehydrogenase flavoprotein C-terminal domain-like	7.073e-16	Direct
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0.00000000000002323	Direct
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0.000000000002591	Direct
55447,54665 55447 - CO dehydrogenase flavoprotein C-terminal domain-like 54665 - CO dehydrogenase molybdoprotein N-domain-like	0.000000001026	Direct
54862,53706 54862 - 4Fe-4S ferredoxins 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3	0.00000106	Direct
54292,54862 54292 - 2Fe-2S ferredoxin-like 54862 - 4Fe-4S ferredoxins	0.000002218	Direct
53706,50692 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 50692 - ADC-like	0.0008641	Direct
50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0.002318	Inherited
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.03435	Inherited
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0.3748	Inherited
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.7682	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54862,53706,50692 54862 - 4Fe-4S ferredoxins 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 50692 - ADC-like	0	Direct
47741,56176,55447 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like 55447 - CO dehydrogenase flavoprotein C-terminal domain-like	0.000000000001641	Direct
54292,47741,56176 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0.000000000002591	Direct
56176,55447,54665 56176 - FAD-binding/transporter-associated domain-like 55447 - CO dehydrogenase flavoprotein C-terminal domain-like 54665 - CO dehydrogenase molybdoprotein N-domain-like	0.000000001026	Direct
55447,54665,56003 55447 - CO dehydrogenase flavoprotein C-terminal domain-like 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	0.000000001026	Direct
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0.000000001828	Direct
54292,54862,53706 54292 - 2Fe-2S ferredoxin-like 54862 - 4Fe-4S ferredoxins 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3	0.00000106	Direct
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.03435	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Enzyme Commission (EC): Acting on CH or CH(2) groups

Superfamily

Family

Supra-domain (including individual superfamily)