Enzyme Commission (EC): Acting on the aldehyde or oxo group of donors

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: root [root] <7>

+ 1: Oxidoreductases [1] <26> (213|314) (212|187|94)

0: Acting on the aldehyde or oxo group of donors [1.2] <8> (34|38) (34|27|14)

- 1: With NAD(+) or NADP(+) as acceptor [1.2.1] <105> (14|15) (14|10|3)

- 1: With oxygen as acceptor [1.2.3] <15> (9|8) (9|6|4)

- 1: With an iron-sulfur protein as acceptor [1.2.7] <12> (11|8) (11|8|3)

- 1: With other acceptors [1.2.99] <10> (6|5) (6|3|0)

- 1: With a cytochrome as acceptor [1.2.2] <4> (0|0) (0|0|0)

- 1: With a disulfide as acceptor [1.2.4] <4> (3|7) (3|2|1)

- 1: With a quinone or similar compound as acceptor [1.2.5] <3> (1|1) (1|0|0)

- 1: With other, known, acceptors [1.2.98] <1> (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
ALDH-like	0	Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	Direct
Ribbon-helix-helix	0	Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain	0	Direct
Glutamyl tRNA-reductase dimerization domain	0	Direct
N-terminal domain of bifunctional PutA protein	0	Direct
CO dehydrogenase ISP C-domain like	0	Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain	0	Direct
TK C-terminal domain-like	0	Direct
Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
Molybdenum cofactor-binding domain	0	Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains	0	Direct
NAD(P)-binding Rossmann-fold domains	0	Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	2.574e-16	Direct
CO dehydrogenase flavoprotein C-terminal domain-like	0.000000000000001269	Direct
FAD-linked reductases, C-terminal domain	0.0000000001038	Direct
CoA-dependent acyltransferases	0.000001423	Direct
ACP-like	0.0007454	Direct
Galactose oxidase, central domain	0.000761	Direct
Alpha subunit of glutamate synthase, C-terminal domain	0.001723	Inherited
2Fe-2S ferredoxin-like	0.00184	Inherited
Prismane protein-like	0.05655	Inherited
alpha-helical ferredoxin	0.5114	Inherited
Acetyl-CoA synthetase-like	0.8084	Inherited
FAD-linked oxidoreductase	0.89	Inherited
4Fe-4S ferredoxins	1	Inherited
E set domains	1	Inherited
FAD/NAD(P)-binding domain	1	Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like	1	Inherited
RmlC-like cupins	1	Inherited
ADC-like	1	Inherited
FAD-binding/transporter-associated domain-like	1	Inherited
Carbamate kinase-like	1	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Branched-chain alpha-keto acid dehydrogenase PP module	0	Direct
ALDH-like	0	Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains	0	Direct
Carbon monoxide dehydrogenase	0	Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain	0	Direct
PutA pre-N-terminal region-like	0	Direct
Aminoacid dehydrogenase-like, C-terminal domain	0	Direct
Glutamyl tRNA-reductase dimerization domain	0	Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	Direct
PFOR Pyr module	0	Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain	0	Direct
GMC oxidoreductases	0	Direct
GAPDH-like	0	Direct
N-terminal domain of bifunctional PutA protein	0	Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	0	Direct
CO dehydrogenase flavoprotein N-terminal domain-like	3.693e-16	Direct
Molybdenum cofactor-binding domain	3.693e-16	Direct
CO dehydrogenase ISP C-domain like	9.189e-16	Direct
CO dehydrogenase molybdoprotein N-domain-like	9.189e-16	Direct
PFOR PP module	0.000000000000003816	Direct
CO dehydrogenase flavoprotein C-terminal domain-like	0.000000000000009037	Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain II	0.0000000000001987	Direct
FAD-linked reductases, N-terminal domain	0.000000001285	Direct
Transketolase C-terminal domain-like	0.000000008276	Direct
TK-like Pyr module	0.000001064	Direct
Peptidyl carrier domain	0.000008118	Direct
CAT-like	0.00001372	Direct
2Fe-2S ferredoxin domains from multidomain proteins	0.00003052	Direct
Galactose oxidase, central domain	0.0002646	Direct
Germin/Seed storage 7S protein	0.0002646	Direct
Alpha subunit of glutamate synthase, C-terminal domain	0.002231	Inherited
TK-like PP module	0.003106	Inherited
Proline dehydrohenase domain of bifunctional PutA protein	0.1755	Inherited
PyrH-like	0.816	Inherited
Acetyl-CoA synthetase-like	0.9126	Inherited
Tyrosine-dependent oxidoreductases	1	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Aldehyde ferredoxin oxidoreductase, C-terminal domains	0	Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain	0	Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	0	Direct
NAD(P)-binding Rossmann-fold domains	0	Direct
Glutamyl tRNA-reductase dimerization domain	0	Direct
Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
Ribbon-helix-helix	0	Direct
Molybdenum cofactor-binding domain	0	Direct
CO dehydrogenase ISP C-domain like	0	Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	Direct
N-terminal domain of bifunctional PutA protein	0	Direct
TK C-terminal domain-like	0	Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain	0	Direct
ALDH-like	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	1.78e-16	Direct
CO dehydrogenase flavoprotein C-terminal domain-like	8.835e-16	Direct
FAD-linked reductases, C-terminal domain	0.00000000007628	Direct
CoA-dependent acyltransferases	0.000001111	Direct
ACP-like	0.0006124	Direct
Galactose oxidase, central domain	0.0006255	Direct
Alpha subunit of glutamate synthase, C-terminal domain	0.001431	Inherited
2Fe-2S ferredoxin-like	0.001529	Inherited
Prismane protein-like	0.04895	Inherited
alpha-helical ferredoxin	0.4674	Inherited
Acetyl-CoA synthetase-like	0.7444	Inherited
FAD-linked oxidoreductase	0.8212	Inherited
Carbamate kinase-like	0.9677	Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like	1	Inherited
RmlC-like cupins	1	Inherited
4Fe-4S ferredoxins	1	Inherited
E set domains	1	Inherited
ADC-like	1	Inherited
FAD-binding/transporter-associated domain-like	1	Inherited
FAD/NAD(P)-binding domain	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54862,52518 54862 - 4Fe-4S ferredoxins 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
69742,51735 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0	Direct
53720,56796 53720 - ALDH-like 56796 - Dehydroquinate synthase-like	0	Direct
51730,53720 51730 - FAD-linked oxidoreductase 53720 - ALDH-like	0	Direct
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	Direct
47598,81935 47598 - Ribbon-helix-helix 81935 - N-terminal domain of bifunctional PutA protein	0	Direct
52518,54862 52518 - Thiamin diphosphate-binding fold (THDP-binding) 54862 - 4Fe-4S ferredoxins	0	Direct
53323,52518 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0	Direct
51735,69075 51735 - NAD(P)-binding Rossmann-fold domains 69075 - Glutamyl tRNA-reductase dimerization domain	0	Direct
53633,53720 53633 - Carbamate kinase-like 53720 - ALDH-like	0	Direct
53323,54862 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 54862 - 4Fe-4S ferredoxins	0	Direct
56228,48310 56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain 48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains	0	Direct
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0	Direct
56821,46548 56821 - Prismane protein-like 46548 - alpha-helical ferredoxin	0	Direct
81935,51730 81935 - N-terminal domain of bifunctional PutA protein 51730 - FAD-linked oxidoreductase	0	Direct
69336,50692 69336 - Alpha subunit of glutamate synthase, C-terminal domain 50692 - ADC-like	0	Direct
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	1.78e-16	Direct
55447,54665 55447 - CO dehydrogenase flavoprotein C-terminal domain-like 54665 - CO dehydrogenase molybdoprotein N-domain-like	5.316e-16	Direct
56176,55447 56176 - FAD-binding/transporter-associated domain-like 55447 - CO dehydrogenase flavoprotein C-terminal domain-like	8.835e-16	Direct
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0.00000000000000176	Direct
51905,54373 51905 - FAD/NAD(P)-binding domain 54373 - FAD-linked reductases, C-terminal domain	0.000000000001115	Direct
52777,56801 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like	0.0000001258	Direct
52922,52518 52922 - TK C-terminal domain-like 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0.000004399	Direct
52922,53323 52922 - TK C-terminal domain-like 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	0.0002023	Direct
50965,81296 50965 - Galactose oxidase, central domain 81296 - E set domains	0.0002023	Direct

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
81935,51730,53720 81935 - N-terminal domain of bifunctional PutA protein 51730 - FAD-linked oxidoreductase 53720 - ALDH-like	0	Direct
47598,81935,51730 47598 - Ribbon-helix-helix 81935 - N-terminal domain of bifunctional PutA protein 51730 - FAD-linked oxidoreductase	0	Direct
52518,52922,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
52518,52922,53323 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	0	Direct
52922,52518,54862 52922 - TK C-terminal domain-like 52518 - Thiamin diphosphate-binding fold (THDP-binding) 54862 - 4Fe-4S ferredoxins	0	Direct
69742,51735,69075 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains 69075 - Glutamyl tRNA-reductase dimerization domain	0	Direct
53323,54862,52518 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 54862 - 4Fe-4S ferredoxins 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
53323,52518,52922 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0	Direct
52922,53323,54862 52922 - TK C-terminal domain-like 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 54862 - 4Fe-4S ferredoxins	0	Direct
56176,55447,54665 56176 - FAD-binding/transporter-associated domain-like 55447 - CO dehydrogenase flavoprotein C-terminal domain-like 54665 - CO dehydrogenase molybdoprotein N-domain-like	5.316e-16	Direct
55447,54665,56003 55447 - CO dehydrogenase flavoprotein C-terminal domain-like 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	5.316e-16	Direct
54292,47741,56176 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0.00000000000000176	Direct
47741,56176,55447 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like 55447 - CO dehydrogenase flavoprotein C-terminal domain-like	0.000000000000008896	Direct
52518,52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0.2628	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

SEARCH

BROWSE

TOOLS

ABOUT

HELP

Enzyme Commission (EC): Acting on the aldehyde or oxo group of donors

Superfamily

Family

Supra-domain (including individual superfamily)