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Enzyme Commission (EC): With NAD(+) or NADP(+) as acceptor

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Oxidoreductases [1] <26>(213|314) (212|187|94)
+ 1:   Acting on the aldehyde or oxo group of donors [1.2] <8>(34|38) (34|27|14)
0:   With NAD(+) or NADP(+) as acceptor [1.2.1] <105>(14|15) (14|10|3)
- 1:   (R)-dehydropantoate dehydrogenase [1.2.1.33](0|0) (0|0|0)
- 1:   2,5-dioxovalerate dehydrogenase [1.2.1.26](0|0) (0|0|0)
- 1:   2-formylbenzoate dehydrogenase [1.2.1.78](0|0) (0|0|0)
- 1:   2-hydroxy-2-methylpropanal dehydrogenase [1.2.1.98](0|0) (0|0|0)
- 1:   2-hydroxymuconate-6-semialdehyde dehydrogenase [1.2.1.85](0|0) (0|0|0)
- 1:   2-oxoaldehyde dehydrogenase (NAD(+)) [1.2.1.23](0|0) (0|0|0)
- 1:   2-oxoaldehyde dehydrogenase (NADP(+)) [1.2.1.49](0|0) (0|0|0)
- 1:   2-oxoisovalerate dehydrogenase (acylating) [1.2.1.25](0|0) (0|0|0)
- 1:   3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+)) [1.2.1.77](0|0) (0|0|0)
- 1:   3,6-anhydro-alpha-L-galactose dehydrogenase [1.2.1.92](0|0) (0|0|0)
- 1:   3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase [1.2.1.91](0|0) (0|0|0)
- 1:   3-succinoylsemialdehyde-pyridine dehydrogenase [1.2.1.83](0|0) (0|0|0)
- 1:   3-sulfolactaldehyde dehydrogenase [1.2.1.97](0|0) (0|0|0)
- 1:   4-(gamma-glutamylamino)butanal dehydrogenase [1.2.1.99](0|0) (0|0|0)
- 1:   4-formylbenzenesulfonate dehydrogenase [1.2.1.62](0|0) (0|0|0)
- 1:   4-hydroxybenzaldehyde dehydrogenase (NAD(+)) [1.2.1.64](0|0) (0|0|0)
- 1:   4-hydroxybenzaldehyde dehydrogenase (NADP(+)) [1.2.1.96](0|0) (0|0|0)
- 1:   4-hydroxymuconic-semialdehyde dehydrogenase [1.2.1.61](0|0) (0|0|0)
- 1:   4-hydroxyphenylacetaldehyde dehydrogenase [1.2.1.53](0|0) (0|0|0)
- 1:   4-trimethylammoniobutyraldehyde dehydrogenase [1.2.1.47](0|0) (0|0|0)
- 1:   5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [1.2.1.60](0|0) (0|0|0)
- 1:   5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase [1.2.1.100](0|0) (0|0|0)
- 1:   6-oxohexanoate dehydrogenase [1.2.1.63](0|0) (0|0|0)
- 1:   Abieta-7,13-dien-18-al dehydrogenase [1.2.1.74](0|0) (0|0|0)
- 1:   Acetaldehyde dehydrogenase (acetylating) [1.2.1.10](2|2) (2|1|0)
- 1:   Alcohol-forming fatty acyl-CoA reductase [1.2.1.84](0|0) (0|0|0)
- 1:   Aldehyde dehydrogenase (NAD(+)) [1.2.1.3](1|1) (1|0|0)
- 1:   Aldehyde dehydrogenase (NAD(P)(+)) [1.2.1.5](0|1) (1|0|0)
- 1:   Aldehyde dehydrogenase (NADP(+)) [1.2.1.4](0|0) (0|0|0)
- 1:   Aminobutyraldehyde dehydrogenase [1.2.1.19](1|1) (1|0|0)
- 1:   Aminomuconate-semialdehyde dehydrogenase [1.2.1.32](0|0) (0|0|0)
- 1:   Aryl-aldehyde dehydrogenase [1.2.1.29](0|0) (0|0|0)
- 1:   Aspartate-semialdehyde dehydrogenase [1.2.1.11](2|2) (2|1|0)
- 1:   Benzaldehyde dehydrogenase (NAD(+)) [1.2.1.28](0|0) (0|0|0)
- 1:   Benzaldehyde dehydrogenase (NADP(+)) [1.2.1.7](0|0) (0|0|0)
- 1:   Beta-apo-4'-carotenal oxygenase [1.2.1.82](0|0) (0|0|0)
- 1:   Betaine-aldehyde dehydrogenase [1.2.1.8](2|2) (2|1|0)
- 1:   Butanal dehydrogenase [1.2.1.57](0|0) (0|0|0)
- 1:   Carboxylate reductase (NADP(+)) [1.2.1.30](0|0) (0|0|0)
- 1:   Cinnamoyl-CoA reductase [1.2.1.44](0|1) (0|0|0)
- 1:   Coniferyl-aldehyde dehydrogenase [1.2.1.68](0|0) (0|0|0)
- 1:   D-glyceraldehyde dehydrogenase (NADP(+)) [1.2.1.89](0|0) (0|0|0)
- 1:   Deleted entry [1.2.1.6](0|0) (0|0|0)
- 1:   Deleted entry [1.2.1.40](0|0) (0|0|0)
- 1:   Erythrose-4-phosphate dehydrogenase [1.2.1.72](2|2) (2|1|0)
- 1:   Farnesal dehydrogenase [1.2.1.94](0|0) (0|0|0)
- 1:   Fatty acyl-CoA reductase [1.2.1.n2](0|0) (0|0|0)
- 1:   Fluoroacetaldehyde dehydrogenase [1.2.1.69](0|0) (0|0|0)
- 1:   Formaldehyde dehydrogenase [1.2.1.46](0|0) (0|0|0)
- 1:   Gamma-guanidinobutyraldehyde dehydrogenase [1.2.1.54](0|0) (0|0|0)
- 1:   Geranial dehydrogenase [1.2.1.86](0|0) (0|0|0)
- 1:   Glutamate-5-semialdehyde dehydrogenase [1.2.1.41](2|2) (2|1|0)
- 1:   Glutamyl-tRNA reductase [1.2.1.70](3|3) (3|2|1)
- 1:   Glutarate-semialdehyde dehydrogenase [1.2.1.20](0|0) (0|0|0)
- 1:   Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) [1.2.1.90](0|0) (0|0|0)
- 1:   Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating) [1.2.1.59](2|2) (2|1|0)
- 1:   Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) [1.2.1.9](0|0) (0|0|0)
- 1:   Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating) [1.2.1.13](1|2) (1|1|0)
- 1:   Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [1.2.1.12](2|2) (2|1|0)
- 1:   Glycolaldehyde dehydrogenase [1.2.1.21](0|0) (0|0|0)
- 1:   Glyoxylate dehydrogenase (acylating) [1.2.1.17](0|0) (0|0|0)
- 1:   Hexadecanal dehydrogenase (acylating) [1.2.1.42](0|0) (0|0|0)
- 1:   Isopyridoxal dehydrogenase (5-pyridoxate-forming) [1.2.1.102](0|0) (0|0|0)
- 1:   L-2-aminoadipate reductase [1.2.1.95](3|2) (3|1|0)
- 1:   L-aminoadipate-semialdehyde dehydrogenase [1.2.1.31](3|2) (3|1|0)
- 1:   L-glutamate gamma-semialdehyde dehydrogenase [1.2.1.88](4|4) (4|3|2)
- 1:   L-tyrosine reductase [1.2.1.101](0|0) (0|0|0)
- 1:   Lactaldehyde dehydrogenase [1.2.1.22](0|0) (0|0|0)
- 1:   Long-chain acyl-[acyl-carrier-protein] reductase [1.2.1.80](0|0) (0|0|0)
- 1:   Long-chain-aldehyde dehydrogenase [1.2.1.48](0|0) (0|0|0)
- 1:   Long-chain-fatty-acyl-CoA reductase [1.2.1.50](0|0) (0|0|0)
- 1:   Malonate-semialdehyde dehydrogenase [1.2.1.15](0|0) (0|0|0)
- 1:   Malonate-semialdehyde dehydrogenase (acetylating) [1.2.1.18](0|0) (0|0|0)
- 1:   Malonyl CoA reductase (malonate semialdehyde-forming) [1.2.1.75](0|0) (0|0|0)
- 1:   Methylmalonate-semialdehyde dehydrogenase (CoA acylating) [1.2.1.27](1|1) (1|0|0)
- 1:   N-acetyl-gamma-glutamyl-phosphate reductase [1.2.1.38](2|2) (2|1|0)
- 1:   Oxoglutarate dehydrogenase (NADP(+)) [1.2.1.52](0|0) (0|0|0)
- 1:   Phenylacetaldehyde dehydrogenase [1.2.1.39](0|0) (0|0|0)
- 1:   Phenylglyoxylate dehydrogenase (acylating) [1.2.1.58](0|0) (0|0|0)
- 1:   Propanal dehydrogenase (CoA-propanoylating) [1.2.1.87](0|0) (0|0|0)
- 1:   Pyruvate dehydrogenase (NADP(+)) [1.2.1.51](0|0) (0|0|0)
- 1:   Retinal dehydrogenase [1.2.1.36](1|1) (1|0|0)
- 1:   Salicylaldehyde dehydrogenase [1.2.1.65](0|0) (0|0|0)
- 1:   Succinate-semialdehyde dehydrogenase (NAD(+)) [1.2.1.24](0|0) (0|0|0)
- 1:   Succinate-semialdehyde dehydrogenase (NAD(P)(+)) [1.2.1.16](0|0) (0|0|0)
- 1:   Succinate-semialdehyde dehydrogenase (NADP(+)) [1.2.1.79](0|0) (0|0|0)
- 1:   Succinate-semialdehyde dehydrogenase (acetylating) [1.2.1.76](0|0) (0|0|0)
- 1:   Succinylglutamate-semialdehyde dehydrogenase [1.2.1.71](1|1) (1|0|0)
- 1:   Sulfoacetaldehyde dehydrogenase [1.2.1.73](0|0) (0|0|0)
- 1:   Sulfoacetaldehyde dehydrogenase (acylating) [1.2.1.81](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.131 [1.2.1.34](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.203 [1.2.1.35](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.205 [1.2.1.14](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.279 [1.2.1.55](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.280 [1.2.1.56](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.284 and 4.4.1.22 [1.2.1.1](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.306 [1.2.1.66](0|0) (0|0|0)
- 1:   Transferred entry: 1.1.1.312 [1.2.1.45](0|0) (0|0|0)
- 1:   Transferred entry: 1.17.1.10 [1.2.1.43](0|0) (0|0|0)
- 1:   Transferred entry: 1.17.1.11 [1.2.1.93](0|0) (0|0|0)
- 1:   Transferred entry: 1.17.1.4 [1.2.1.37](0|0) (0|0|0)
- 1:   Transferred entry: 1.17.1.9 [1.2.1.2](0|0) (0|0|0)
- 1:   Transferred entry: 1.2.1.77 [1.2.1.n1](0|0) (0|0|0)
- 1:   Transferred entry: 1.2.1.86 [1.2.1.n3](0|0) (0|0|0)
- 1:   Vanillin dehydrogenase [1.2.1.67](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ALDH-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Ribbon-helix-helix0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
N-terminal domain of bifunctional PutA protein0Direct
FAD-linked reductases, C-terminal domain0Direct
NAD(P)-binding Rossmann-fold domains0Direct
FAD/NAD(P)-binding domain0.000005743Direct
ACP-like0.0000191Direct
FAD-linked oxidoreductase0.001121Inherited
Acetyl-CoA synthetase-like0.6269Inherited
Carbamate kinase-like0.8702Inherited
CoA-dependent acyltransferases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
ALDH-like0Direct
PutA pre-N-terminal region-like0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
FAD-linked reductases, N-terminal domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
GMC oxidoreductases0Direct
GAPDH-like0Direct
N-terminal domain of bifunctional PutA protein0Direct
Peptidyl carrier domain0.000004463Direct
Proline dehydrohenase domain of bifunctional PutA protein0.00002428Direct
PyrH-like0.6346Inherited
Acetyl-CoA synthetase-like0.8028Inherited
Tyrosine-dependent oxidoreductases1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
NAD(P)-binding Rossmann-fold domains0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
Ribbon-helix-helix0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
N-terminal domain of bifunctional PutA protein0Direct
FAD-linked reductases, C-terminal domain0Direct
ALDH-like0Direct
FAD/NAD(P)-binding domain0.000004519Direct
ACP-like0.00001521Direct
FAD-linked oxidoreductase0.0009247Direct
Acetyl-CoA synthetase-like0.5754Inherited
Carbamate kinase-like0.8028Inherited
CoA-dependent acyltransferases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
69742,51735
  • 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    53720,56796
  • 53720 - ALDH-like
  • 56796 - Dehydroquinate synthase-like
  • 0Direct
    51730,53720
  • 51730 - FAD-linked oxidoreductase
  • 53720 - ALDH-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    47598,81935
  • 47598 - Ribbon-helix-helix
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 0Direct
    51735,69075
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 69075 - Glutamyl tRNA-reductase dimerization domain
  • 0Direct
    53633,53720
  • 53633 - Carbamate kinase-like
  • 53720 - ALDH-like
  • 0Direct
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    81935,51730
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 0Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.00000005426Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81935,51730,53720
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 53720 - ALDH-like
  • 0Direct
    47598,81935,51730
  • 47598 - Ribbon-helix-helix
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 0Direct
    69742,51735,69075
  • 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 69075 - Glutamyl tRNA-reductase dimerization domain
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)