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Enzyme Commission (EC): Acting on the CH-CH group of donors
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| "Helical backbone" metal receptor | 0 | DIRECT |
| Heme oxygenase-like | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| alpha-helical ferredoxin | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0.00000000000001828 | DIRECT |
| FabD/lysophospholipase-like | 0.0000002666 | DIRECT |
| Tudor/PWWP/MBT | 0.00004062 | DIRECT |
| Chorismate mutase II | 0.00008261 | DIRECT |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0002281 | DIRECT |
| Nucleotide-binding domain | 0.0004176 | DIRECT |
| ACP-like | 0.004702 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Ubiquitin-like | 0.005616 | INHERITED FROM: Very-long-chain enoyl-CoA reductase || With NAD(+) or NADP(+) as acceptor |
| FAD/NAD(P)-binding domain | 0.02713 | INHERITED FROM: With a quinone or related compound as acceptor || 15-cis-phytoene desaturase || 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) || 9,9'-di-cis-zeta-carotene desaturase || Succinate dehydrogenase (quinone) || 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase || With other acceptors || Fumarate reductase (quinol) || Geranylgeranyl diphosphate reductase || Protoporphyrinogen oxidase || Fumarate reductase (NADH) |
| GroES-like | 0.0275 | INHERITED FROM: 2-methylene-furan-3-one reductase || With NAD(+) or NADP(+) as acceptor || 2-alkenal reductase (NAD(P)(+)) || Acrylyl-CoA reductase (NADPH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || 15-oxoprostaglandin 13-reductase || Enoyl-[acyl-carrier-protein] reductase |
| ACT-like | 0.2832 | INHERITED FROM: Prephenate dehydrogenase |
| Thioesterase/thiol ester dehydrase-isomerase | 0.4306 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
| Multiheme cytochromes | 0.7521 | INHERITED FROM: With a quinone or related compound as acceptor || Fumarate reductase (quinol) |
| 4Fe-4S ferredoxins | 1 | INHERITED FROM: Dihydrouracil dehydrogenase (NAD(+)) || With NAD(+) or NADP(+) as acceptor || Dihydropyrimidine dehydrogenase (NADP(+)) |
| Radical SAM enzymes | 1 | INHERITED FROM: With other, known, acceptors || Coproporphyrinogen dehydrogenase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || Biliverdin reductase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| NAD(P)-linked oxidoreductase | 1 | INHERITED FROM: Delta(4)-3-oxosteroid 5-beta-reductase || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| Inosine monophosphate dehydrogenase (IMPDH) | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
| Flavoproteins | 1 | INHERITED FROM: With other acceptors || Urocanate reductase |
| Thiolase-like | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: With oxygen as acceptor || Protoporphyrinogen oxidase |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 1 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Prephenate dehydrogenase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: With an iron-sulfur protein as acceptor || Ferredoxin:protochlorophyllide reductase (ATP-dependent) |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) || With NAD(+) or NADP(+) as acceptor || Prephenate dehydrogenase || Protochlorophyllide reductase || 2,4-dienoyl-CoA reductase (NADPH) || 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase || Precorrin-2 dehydrogenase || 15-oxoprostaglandin 13-reductase || Enoyl-[acyl-carrier-protein] reductase |
| Dehydroquinate synthase-like | 1 | INHERITED FROM: Maleylacetate reductase |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| TyrA dimerization domain-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| Biliverdin reductase | 0 | DIRECT |
| Nitrogenase iron-molybdenum protein | 0 | DIRECT |
| Siroheme synthase N-terminal domain-like | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| PqqC-like | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| Oxygen-independent coproporphyrinogen III oxidase HemN | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain | 0 | DIRECT |
| Dihydropyrimidine dehydrogenase, N-terminal domain | 0.000000000009313 | DIRECT |
| Acyl-carrier protein (ACP) | 0.00000000003432 | DIRECT |
| FabD-like | 0.0000000002618 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00000002109 | DIRECT |
| N-terminal domain of adrenodoxin reductase-like | 0.00000005312 | DIRECT |
| Tudor domain | 0.0000006461 | DIRECT |
| Tyrosine-dependent oxidoreductases | 0.000001134 | DIRECT |
| MaoC-like | 0.0001295 | DIRECT |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0006392 | DIRECT |
| L-aminoacid/polyamine oxidase | 0.0007251 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0.00553 | INHERITED FROM: 2-methylene-furan-3-one reductase || With NAD(+) or NADP(+) as acceptor || 2-alkenal reductase (NAD(P)(+)) || Acrylyl-CoA reductase (NADPH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || 15-oxoprostaglandin 13-reductase || Enoyl-[acyl-carrier-protein] reductase |
| Ferredoxin domains from multidomain proteins | 0.01145 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydropyrimidine dehydrogenase (NADP(+)) |
| Alcohol dehydrogenase-like, N-terminal domain | 0.02227 | INHERITED FROM: 2-methylene-furan-3-one reductase || With NAD(+) or NADP(+) as acceptor || 2-alkenal reductase (NAD(P)(+)) || Acrylyl-CoA reductase (NADPH) || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || 15-oxoprostaglandin 13-reductase || Enoyl-[acyl-carrier-protein] reductase |
| NADPH-dependent FMN reductase | 0.1188 | INHERITED FROM: With other acceptors || Urocanate reductase |
| Thiolase-related | 0.2322 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Glucose 6-phosphate dehydrogenase-like | 0.3167 | INHERITED FROM: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| Di-heme elbow motif | 0.6825 | INHERITED FROM: With a quinone or related compound as acceptor || Fumarate reductase (quinol) |
| Iron-containing alcohol dehydrogenase | 0.8241 | INHERITED FROM: Maleylacetate reductase || With NAD(+) or NADP(+) as acceptor |
| Aldo-keto reductases (NADP) | 0.9364 | INHERITED FROM: Delta(4)-3-oxosteroid 5-beta-reductase || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Prephenate dehydrogenase |
| FAD-linked reductases, N-terminal domain | 1 | INHERITED FROM: With oxygen as acceptor || Protoporphyrinogen oxidase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || Biliverdin reductase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| TyrA dimerization domain-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Coproporphyrinogen III oxidase | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| Biliverdin reductase | 0 | Direct |
| Nitrogenase iron-molybdenum protein | 0 | Direct |
| Siroheme synthase N-terminal domain-like | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| PqqC-like | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| Oxygen-independent coproporphyrinogen III oxidase HemN | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | Direct |
| Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain | 0 | Direct |
| Dihydropyrimidine dehydrogenase, N-terminal domain | 0.000000000009313 | Direct |
| Acyl-carrier protein (ACP) | 0.00000000003432 | Direct |
| FabD-like | 0.0000000002618 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00000002109 | Direct |
| N-terminal domain of adrenodoxin reductase-like | 0.00000005312 | Direct |
| Tudor domain | 0.0000006461 | Direct |
| Tyrosine-dependent oxidoreductases | 0.000001134 | Direct |
| MaoC-like | 0.0001295 | Direct |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0006392 | Direct |
| L-aminoacid/polyamine oxidase | 0.0007251 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0.00553 | Inherited |
| Ferredoxin domains from multidomain proteins | 0.01145 | Inherited |
| Alcohol dehydrogenase-like, N-terminal domain | 0.02227 | Inherited |
| NADPH-dependent FMN reductase | 0.1188 | Inherited |
| Thiolase-related | 0.2322 | Inherited |
| Glucose 6-phosphate dehydrogenase-like | 0.3167 | Inherited |
| Di-heme elbow motif | 0.6825 | Inherited |
| Iron-containing alcohol dehydrogenase | 0.8241 | Inherited |
| Aldo-keto reductases (NADP) | 0.9364 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 1 | Inherited |
| FAD-linked reductases, N-terminal domain | 1 | Inherited |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Heme oxygenase-like | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Coproporphyrinogen III oxidase | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| "Helical backbone" metal receptor | 0 | DIRECT |
| Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| alpha-helical ferredoxin | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0.00000000000001288 | DIRECT |
| FabD/lysophospholipase-like | 0.0000002052 | DIRECT |
| Tudor/PWWP/MBT | 0.00003248 | DIRECT |
| Chorismate mutase II | 0.00006645 | DIRECT |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0001852 | DIRECT |
| Nucleotide-binding domain | 0.0003406 | DIRECT |
| ACP-like | 0.003942 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| Ubiquitin-like | 0.004719 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Very-long-chain enoyl-CoA reductase |
| FAD/NAD(P)-binding domain | 0.02326 | INHERITED FROM: 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase || 15-cis-phytoene desaturase || 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) || Succinate dehydrogenase (quinone) || With a quinone or related compound as acceptor || Fumarate reductase (NADH) || Fumarate reductase (quinol) || Geranylgeranyl diphosphate reductase || 9,9'-di-cis-zeta-carotene desaturase || Protoporphyrinogen oxidase || With other acceptors |
| GroES-like | 0.02358 | INHERITED FROM: 2-methylene-furan-3-one reductase || With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase || 2-alkenal reductase (NAD(P)(+)) || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || 15-oxoprostaglandin 13-reductase || Acrylyl-CoA reductase (NADPH) |
| ACT-like | 0.2549 | INHERITED FROM: Prephenate dehydrogenase |
| Thioesterase/thiol ester dehydrase-isomerase | 0.3914 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
| Multiheme cytochromes | 0.6919 | INHERITED FROM: With a quinone or related compound as acceptor || Fumarate reductase (quinol) |
| NAD(P)-linked oxidoreductase | 0.9475 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || Delta(4)-3-oxosteroid 5-beta-reductase |
| 4Fe-4S ferredoxins | 0.9531 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrouracil dehydrogenase (NAD(+)) || Dihydropyrimidine dehydrogenase (NADP(+)) |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 1 | INHERITED FROM: Prephenate dehydrogenase || With NAD(+) or NADP(+) as acceptor |
| Dehydroquinate synthase-like | 1 | INHERITED FROM: Maleylacetate reductase |
| Radical SAM enzymes | 1 | INHERITED FROM: With other, known, acceptors || Coproporphyrinogen dehydrogenase |
| Inosine monophosphate dehydrogenase (IMPDH) | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Prephenate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Precorrin-2 dehydrogenase || Protochlorophyllide reductase || Enoyl-[acyl-carrier-protein] reductase || Enoyl-[acyl-carrier-protein] reductase (NADH) || 15-oxoprostaglandin 13-reductase || 2,4-dienoyl-CoA reductase (NADPH) || 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Ferredoxin:protochlorophyllide reductase (ATP-dependent) || With an iron-sulfur protein as acceptor |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Biliverdin reductase || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
| Flavoproteins | 1 | INHERITED FROM: Urocanate reductase || With other acceptors |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: Protoporphyrinogen oxidase || With oxygen as acceptor |
| Thiolase-like | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
51971,51395
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54292,46548
54292 - 2Fe-2S ferredoxin-like
46548 - alpha-helical ferredoxin | 0 | DIRECT |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
48695,51905
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
48179,55021
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51395,54862
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
56176,56194
56176 - FAD-binding/transporter-associated domain-like
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000001058 | DIRECT |
46548,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain | 0.00000000195 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.000002657 | DIRECT |
51971,51971
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0.000006277 | DIRECT |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.000006775 | DIRECT |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0001852 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.02114 | INHERITED FROM: 2-methylene-furan-3-one reductase || With NAD(+) or NADP(+) as acceptor || Enoyl-[acyl-carrier-protein] reductase || 2-alkenal reductase (NAD(P)(+)) || Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) || 15-oxoprostaglandin 13-reductase || Acrylyl-CoA reductase (NADPH) |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.2842 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 2-alkenal reductase (NAD(P)(+)) || 15-oxoprostaglandin 13-reductase |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Biliverdin reductase || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 1 | INHERITED FROM: Prephenate dehydrogenase || With NAD(+) or NADP(+) as acceptor |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: Protoporphyrinogen oxidase || With oxygen as acceptor |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
51971,51395
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54292,46548
54292 - 2Fe-2S ferredoxin-like
46548 - alpha-helical ferredoxin | 0 | Direct |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | Direct |
48695,51905
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
48179,55021
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51395,54862
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | Direct |
56176,56194
56176 - FAD-binding/transporter-associated domain-like
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000001058 | Direct |
46548,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain | 0.00000000195 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.000002657 | Direct |
51971,51971
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0.000006277 | Direct |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.000006775 | Direct |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0001852 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.02114 | Inherited |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.2842 | Inherited |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 1 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51735,48179,55021
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | DIRECT |
48695,51905,56425
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51971,51971,51395
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | DIRECT |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
51971,51395,54862
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000000005515 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00000005559 | DIRECT |
46548,51971,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0.0000000652 | DIRECT |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.000004003 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.2739 | INHERITED FROM: With NAD(+) or NADP(+) as acceptor || 2-alkenal reductase (NAD(P)(+)) || 15-oxoprostaglandin 13-reductase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51735,48179,55021
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
55021 - ACT-like | 0 | Direct |
48695,51905,56425
48695 - Multiheme cytochromes
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51971,51971,51395
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases | 0 | Direct |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
51971,51395,54862
51971 - Nucleotide-binding domain
51395 - FMN-linked oxidoreductases
54862 - 4Fe-4S ferredoxins | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000000000005515 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00000005559 | Direct |
46548,51971,51971
46548 - alpha-helical ferredoxin
51971 - Nucleotide-binding domain
51971 - Nucleotide-binding domain | 0.0000000652 | Direct |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.000004003 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.2739 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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