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Enzyme Commission (EC): With NAD(+) or NADP(+) as acceptor
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Shortest distance to current term (+ for parents, - for children) |
EC term [EC ID] <#Children> |
(#SF|#FA) |
#Supra-domain (Single|Duplex|Triple) |
+ + + 3: | root [root] <7> |
+ + 2: | Oxidoreductases [1] <26> | (213|314) |
(212|187|94) |
+ 1: | Acting on the CH-CH group of donors [1.3] <9> | (40|44) |
(40|25|12) |
0: | With NAD(+) or NADP(+) as acceptor [1.3.1] <123> | (28|28) |
(28|20|10) |
- 1: | (+)-pulegone reductase [1.3.1.81] | (0|0) |
(0|0|0) |
- 1: | (-)-isopiperitenone reductase [1.3.1.82] | (0|0) |
(0|0|0) |
- 1: | (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase [1.3.1.53] | (0|0) |
(0|0|0) |
- 1: | (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase [1.3.1.113] | (0|0) |
(0|0|0) |
- 1: | 1,2-dihydrovomilenine reductase [1.3.1.73] | (0|0) |
(0|0|0) |
- 1: | 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase [1.3.1.68] | (0|0) |
(0|0|0) |
- 1: | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase [1.3.1.25] | (0|0) |
(0|0|0) |
- 1: | 12-oxophytodienoate reductase [1.3.1.42] | (1|1) |
(1|0|0) |
- 1: | 15-oxoprostaglandin 13-reductase [1.3.1.48] | (2|2) |
(2|2|1) |
- 1: | 2'-hydroxydaidzein reductase [1.3.1.51] | (0|0) |
(0|0|0) |
- 1: | 2'-hydroxyisoflavone reductase [1.3.1.45] | (0|1) |
(0|0|0) |
- 1: | 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) [1.3.1.101] | (1|0) |
(1|0|0) |
- 1: | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [1.3.1.28] | (0|1) |
(0|0|0) |
- 1: | 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase [1.3.1.58] | (0|0) |
(0|0|0) |
- 1: | 2,4-dienoyl-CoA reductase (NADPH) [1.3.1.34] | (1|1) |
(1|0|0) |
- 1: | 2-alkenal reductase (NAD(P)(+)) [1.3.1.74] | (1|2) |
(1|2|1) |
- 1: | 2-alkenal reductase (NADP(+)) [1.3.1.102] | (0|0) |
(0|0|0) |
- 1: | 2-coumarate reductase [1.3.1.11] | (0|0) |
(0|0|0) |
- 1: | 2-enoate reductase [1.3.1.31] | (0|0) |
(0|0|0) |
- 1: | 2-haloacrylate reductase [1.3.1.103] | (0|0) |
(0|0|0) |
- 1: | 2-hexadecenal reductase [1.3.1.27] | (0|0) |
(0|0|0) |
- 1: | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase [1.3.1.40] | (0|0) |
(0|0|0) |
- 1: | 2-methylene-furan-3-one reductase [1.3.1.105] | (1|2) |
(1|1|0) |
- 1: | 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) [1.3.1.75] | (0|0) |
(0|0|0) |
- 1: | 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase [1.3.1.87] | (1|1) |
(1|0|0) |
- 1: | 3-dehydro-bile acid Delta(4,6)-reductase [1.3.1.114] | (0|0) |
(0|0|0) |
- 1: | 3-methyleneoxindole reductase [1.3.1.17] | (0|0) |
(0|0|0) |
- 1: | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)) [1.3.1.22] | (0|0) |
(0|0|0) |
- 1: | 3-oxocholoyl-CoA 4-desaturase [1.3.1.115] | (0|0) |
(0|0|0) |
- 1: | 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase [1.3.1.65] | (0|0) |
(0|0|0) |
- 1: | 7-beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase [1.3.1.116] | (0|0) |
(0|0|0) |
- 1: | 7-dehydrocholesterol reductase [1.3.1.21] | (0|0) |
(0|0|0) |
- 1: | Acryloyl-CoA reductase (NADH) [1.3.1.95] | (0|0) |
(0|0|0) |
- 1: | Acrylyl-CoA reductase (NADPH) [1.3.1.84] | (1|2) |
(1|1|0) |
- 1: | Acyl-CoA dehydrogenase (NADP(+)) [1.3.1.8] | (0|0) |
(0|0|0) |
- 1: | Alpha-santonin 1,2-reductase [1.3.1.47] | (0|0) |
(0|0|0) |
- 1: | Anthocyanidin reductase ((2R,3R)-flavan-3-ol-forming) [1.3.1.77] | (0|0) |
(0|0|0) |
- 1: | Anthocyanidin reductase ((2S)-flavan-3-ol-forming) [1.3.1.112] | (0|0) |
(0|0|0) |
- 1: | Arogenate dehydrogenase [1.3.1.43] | (0|0) |
(0|0|0) |
- 1: | Arogenate dehydrogenase (NAD(P)(+)) [1.3.1.79] | (0|0) |
(0|0|0) |
- 1: | Arogenate dehydrogenase (NADP(+)) [1.3.1.78] | (0|0) |
(0|0|0) |
- 1: | Artemisinic aldehyde Delta(11(13)) reductase [1.3.1.92] | (0|0) |
(0|0|0) |
- 1: | Beta-nitroacrylate reductase [1.3.1.16] | (0|0) |
(0|0|0) |
- 1: | Biliverdin reductase [1.3.1.24] | (1|2) |
(1|1|0) |
- 1: | Biochanin-A reductase [1.3.1.46] | (0|0) |
(0|0|0) |
- 1: | Botryococcene synthase [1.3.1.97] | (0|0) |
(0|0|0) |
- 1: | Botryococcus squalene synthase [1.3.1.96] | (0|0) |
(0|0|0) |
- 1: | Butanoyl-CoA dehydrogenase (NAD(+),ferredoxin) [1.3.1.109] | (0|0) |
(0|0|0) |
- 1: | Caffeoyl-CoA reductase [1.3.1.108] | (0|0) |
(0|0|0) |
- 1: | Chanoclavine-I aldehyde reductase [1.3.1.100] | (0|0) |
(0|0|0) |
- 1: | Chlorobenzene dihydrodiol dehydrogenase [1.3.1.119] | (0|0) |
(0|0|0) |
- 1: | Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase [1.3.1.29] | (0|1) |
(0|0|0) |
- 1: | Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [1.3.1.19] | (0|0) |
(0|0|0) |
- 1: | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [1.3.1.56] | (0|1) |
(0|0|0) |
- 1: | Cis-2-enoyl-CoA reductase (NADPH) [1.3.1.37] | (0|0) |
(0|0|0) |
- 1: | Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase [1.3.1.49] | (0|0) |
(0|0|0) |
- 1: | Cis-dihydroethylcatechol dehydrogenase [1.3.1.66] | (0|0) |
(0|0|0) |
- 1: | Cobalt-precorrin-6A reductase [1.3.1.106] | (0|0) |
(0|0|0) |
- 1: | Crotonyl-CoA carboxylase/reductase [1.3.1.85] | (0|0) |
(0|0|0) |
- 1: | Crotonyl-CoA reductase [1.3.1.86] | (0|0) |
(0|0|0) |
- 1: | Cucurbitacin Delta(23)-reductase [1.3.1.5] | (0|0) |
(0|0|0) |
- 1: | Curcumin reductase [1.3.1.n3] | (0|0) |
(0|0|0) |
- 1: | Cyclohexane-1-carbonyl-CoA reductase (NADP(+)) [1.3.1.120] | (0|0) |
(0|0|0) |
- 1: | Deleted entry [1.3.1.23] | (0|0) |
(0|0|0) |
- 1: | Deleted entry [1.3.1.61] | (0|0) |
(0|0|0) |
- 1: | Deleted entry [1.3.1.59] | (0|0) |
(0|0|0) |
- 1: | Deleted entry [1.3.1.55] | (0|0) |
(0|0|0) |
- 1: | Delta(14)-sterol reductase [1.3.1.70] | (1|1) |
(1|0|0) |
- 1: | Delta(24(24(1)))-sterol reductase [1.3.1.71] | (0|0) |
(0|0|0) |
- 1: | Delta(24)-sterol reductase [1.3.1.72] | (0|0) |
(0|0|0) |
- 1: | Delta(4)-3-oxosteroid 5-beta-reductase [1.3.1.3] | (1|1) |
(1|0|0) |
- 1: | Dibenzothiophene dihydrodiol dehydrogenase [1.3.1.60] | (0|0) |
(0|0|0) |
- 1: | Dihydroorotate dehydrogenase (NAD(+)) [1.3.1.14] | (1|1) |
(1|0|0) |
- 1: | Dihydroorotate dehydrogenase (NADP(+)) [1.3.1.15] | (0|0) |
(0|0|0) |
- 1: | Dihydropyrimidine dehydrogenase (NADP(+)) [1.3.1.2] | (4|4) |
(4|4|3) |
- 1: | Dihydrouracil dehydrogenase (NAD(+)) [1.3.1.1] | (3|2) |
(3|2|0) |
- 1: | Enoyl-[acyl-carrier-protein] reductase [1.3.1.104] | (2|2) |
(2|1|0) |
- 1: | Enoyl-[acyl-carrier-protein] reductase (NADH) [1.3.1.9] | (4|3) |
(4|2|0) |
- 1: | Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) [1.3.1.39] | (7|8) |
(7|5|3) |
- 1: | Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) [1.3.1.10] | (0|0) |
(0|0|0) |
- 1: | Fumarate reductase (NADH) [1.3.1.6] | (2|2) |
(2|1|0) |
- 1: | Geissoschizine dehydrogenase [1.3.1.36] | (0|0) |
(0|0|0) |
- 1: | Geranylgeranyl diphosphate reductase [1.3.1.83] | (1|0) |
(1|0|0) |
- 1: | Geranylgeranyl-bacteriochlorophyllide a reductase [1.3.1.111] | (0|0) |
(0|0|0) |
- 1: | Hydroxycinnamoyl-CoA reductase [1.3.1.117] | (0|0) |
(0|0|0) |
- 1: | Iridoid synthase [1.3.1.99] | (0|0) |
(0|0|0) |
- 1: | Kynurenate-7,8-dihydrodiol dehydrogenase [1.3.1.18] | (0|0) |
(0|0|0) |
- 1: | Lactate dehydrogenase (NAD(+),ferredoxin) [1.3.1.110] | (0|0) |
(0|0|0) |
- 1: | Maleylacetate reductase [1.3.1.32] | (1|1) |
(1|0|0) |
- 1: | Meromycolic acid enoyl-[acyl-carrier-protein] reductase [1.3.1.118] | (0|0) |
(0|0|0) |
- 1: | Meso-tartrate dehydrogenase [1.3.1.7] | (0|0) |
(0|0|0) |
- 1: | Phloroglucinol reductase [1.3.1.57] | (0|0) |
(0|0|0) |
- 1: | Phthalate 4,5-cis-dihydrodiol dehydrogenase [1.3.1.64] | (0|0) |
(0|0|0) |
- 1: | Pimeloyl-CoA dehydrogenase [1.3.1.62] | (0|0) |
(0|0|0) |
- 1: | Polyprenol reductase [1.3.1.94] | (0|0) |
(0|0|0) |
- 1: | Precorrin-2 dehydrogenase [1.3.1.76] | (3|3) |
(3|2|1) |
- 1: | Precorrin-6A reductase [1.3.1.54] | (0|0) |
(0|0|0) |
- 1: | Prephenate dehydrogenase [1.3.1.12] | (4|2) |
(4|3|2) |
- 1: | Prephenate dehydrogenase (NADP(+)) [1.3.1.13] | (0|0) |
(0|0|0) |
- 1: | Protochlorophyllide reductase [1.3.1.33] | (1|1) |
(1|0|0) |
- 1: | Sanguinarine reductase [1.3.1.107] | (0|0) |
(0|0|0) |
- 1: | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [1.3.1.20] | (2|3) |
(2|1|0) |
- 1: | Trans-2-enoyl-CoA reductase (NAD(+)) [1.3.1.44] | (0|0) |
(0|0|0) |
- 1: | Trans-2-enoyl-CoA reductase (NADPH) [1.3.1.38] | (0|1) |
(0|0|0) |
- 1: | Transferred entry: 1.1.1.252 [1.3.1.50] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.14.19.22 [1.3.1.35] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.14.19.52 [1.3.1.n2] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.17.1.8 [1.3.1.26] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.21.1.2 [1.3.1.63] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.3.1.22 [1.3.1.30] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.3.1.22 [1.3.1.4] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.3.1.87 [1.3.1.n1] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.3.7.12 [1.3.1.80] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 1.3.8.5 [1.3.1.52] | (0|0) |
(0|0|0) |
- 1: | UDP-N-acetylmuramate dehydrogenase [1.3.1.98] | (2|2) |
(2|1|0) |
- 1: | Very-long-chain enoyl-CoA reductase [1.3.1.93] | (1|0) |
(1|0|0) |
- 1: | Xanthommatin reductase [1.3.1.41] | (0|0) |
(0|0|0) |
- 1: | Zeatin reductase [1.3.1.69] | (0|0) |
(0|0|0) |
- 1: | dehydrogenase [1.3.1.67] | (0|0) |
(0|0|0) |
- 1: | tRNA-dihydrouridine(16/17) synthase (NAD(P)(+)) [1.3.1.88] | (0|0) |
(0|0|0) |
- 1: | tRNA-dihydrouridine(20) synthase (NAD(P)(+)) [1.3.1.91] | (1|1) |
(1|0|0) |
- 1: | tRNA-dihydrouridine(20a/20b) synthase (NAD(P)(+)) [1.3.1.90] | (0|0) |
(0|0|0) |
- 1: | tRNA-dihydrouridine(47) synthase (NAD(P)(+)) [1.3.1.89] | (1|1) |
(1|0|0) |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
Tetrapyrrole methylase | 0 | DIRECT |
Nucleotide-binding domain | 0 | DIRECT |
Siroheme synthase middle domains-like | 0 | DIRECT |
NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
GroES-like | 0 | DIRECT |
FAD-binding/transporter-associated domain-like | 0 | DIRECT |
FabD/lysophospholipase-like | 0.00000000001103 | DIRECT |
NAD(P)-linked oxidoreductase | 0.0000001388 | DIRECT |
Tudor/PWWP/MBT | 0.00000043 | DIRECT |
Chorismate mutase II | 0.000001793 | DIRECT |
Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.000002679 | DIRECT |
ACP-like | 0.000006235 | DIRECT |
4Fe-4S ferredoxins | 0.000008291 | DIRECT |
Ubiquitin-like | 0.00005231 | DIRECT |
6-phosphogluconate dehydrogenase C-terminal domain-like | 0.0004251 | DIRECT |
ACT-like | 0.003412 | INHERITED FROM: Prephenate dehydrogenase |
Thioesterase/thiol ester dehydrase-isomerase | 0.011 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
Dehydroquinate synthase-like | 0.03429 | INHERITED FROM: Maleylacetate reductase |
Inosine monophosphate dehydrogenase (IMPDH) | 0.05802 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.2133 | INHERITED FROM: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || Biliverdin reductase |
Thiolase-like | 0.4396 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
alpha/beta-Hydrolases | 0.9463 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
FMN-linked oxidoreductases | 1 | INHERITED FROM: tRNA-dihydrouridine(20) synthase (NAD(P)(+)) || tRNA-dihydrouridine(47) synthase (NAD(P)(+)) || 12-oxophytodienoate reductase || Dihydropyrimidine dehydrogenase (NADP(+)) || Dihydroorotate dehydrogenase (NAD(+)) |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
FAD/NAD(P)-binding domain | 1 | INHERITED FROM: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) || Fumarate reductase (NADH) || Geranylgeranyl diphosphate reductase |
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | INHERITED FROM: Fumarate reductase (NADH) |
alpha-helical ferredoxin | 1 | INHERITED FROM: Dihydrouracil dehydrogenase (NAD(+)) || Dihydropyrimidine dehydrogenase (NADP(+)) |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Highly Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | DIRECT |
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
Dihydropyrimidine dehydrogenase, N-terminal domain | 0 | DIRECT |
Siroheme synthase middle domains-like | 0 | DIRECT |
TyrA dimerization domain-like | 0 | DIRECT |
Tyrosine-dependent oxidoreductases | 0 | DIRECT |
N-terminal domain of adrenodoxin reductase-like | 0 | DIRECT |
FabD-like | 0 | DIRECT |
Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
Tetrapyrrole methylase | 0 | DIRECT |
Biliverdin reductase | 0 | DIRECT |
Siroheme synthase N-terminal domain-like | 0 | DIRECT |
Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Ferredoxin domains from multidomain proteins | 0.000000000000003997 | DIRECT |
Acyl-carrier protein (ACP) | 0.0000000000003765 | DIRECT |
Glucose 6-phosphate dehydrogenase-like | 0.00000000000305 | DIRECT |
MaoC-like | 0.00000000006642 | DIRECT |
Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.0000000002434 | DIRECT |
Tudor domain | 0.0000000079 | DIRECT |
Aldo-keto reductases (NADP) | 0.0000001267 | DIRECT |
Iron-containing alcohol dehydrogenase | 0.0000002611 | DIRECT |
Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.00001953 | DIRECT |
6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.0052 | INHERITED FROM: Prephenate dehydrogenase |
Thiolase-related | 0.0135 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0.2363 | INHERITED FROM: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase || Biliverdin reductase |
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | INHERITED FROM: Fumarate reductase (NADH) |
FMN-linked oxidoreductases | 1 | INHERITED FROM: tRNA-dihydrouridine(20) synthase (NAD(P)(+)) || tRNA-dihydrouridine(47) synthase (NAD(P)(+)) || 12-oxophytodienoate reductase || Dihydropyrimidine dehydrogenase (NADP(+)) || Dihydroorotate dehydrogenase (NAD(+)) |
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 1 | INHERITED FROM: Fumarate reductase (NADH) |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain | 0 | Direct |
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
Dihydropyrimidine dehydrogenase, N-terminal domain | 0 | Direct |
Siroheme synthase middle domains-like | 0 | Direct |
TyrA dimerization domain-like | 0 | Direct |
Tyrosine-dependent oxidoreductases | 0 | Direct |
N-terminal domain of adrenodoxin reductase-like | 0 | Direct |
FabD-like | 0 | Direct |
Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
Tetrapyrrole methylase | 0 | Direct |
Biliverdin reductase | 0 | Direct |
Siroheme synthase N-terminal domain-like | 0 | Direct |
Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
Ferredoxin domains from multidomain proteins | 0.000000000000003997 | Direct |
Acyl-carrier protein (ACP) | 0.0000000000003765 | Direct |
Glucose 6-phosphate dehydrogenase-like | 0.00000000000305 | Direct |
MaoC-like | 0.00000000006642 | Direct |
Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.0000000002434 | Direct |
Tudor domain | 0.0000000079 | Direct |
Aldo-keto reductases (NADP) | 0.0000001267 | Direct |
Iron-containing alcohol dehydrogenase | 0.0000002611 | Direct |
Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.00001953 | Direct |
6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.0052 | Inherited |
Thiolase-related | 0.0135 | Inherited |
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0.2363 | Inherited |
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | Inherited |
FMN-linked oxidoreductases | 1 | Inherited |
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Tetrapyrrole methylase | 0 | DIRECT |
Siroheme synthase middle domains-like | 0 | DIRECT |
Nucleotide-binding domain | 0 | DIRECT |
NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
GroES-like | 0 | DIRECT |
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
FAD-binding/transporter-associated domain-like | 0 | DIRECT |
FabD/lysophospholipase-like | 0.00000000000798 | DIRECT |
NAD(P)-linked oxidoreductase | 0.0000001063 | DIRECT |
Tudor/PWWP/MBT | 0.0000003326 | DIRECT |
Chorismate mutase II | 0.000001404 | DIRECT |
Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0000021 | DIRECT |
ACP-like | 0.000004907 | DIRECT |
4Fe-4S ferredoxins | 0.000006543 | DIRECT |
Ubiquitin-like | 0.00004192 | DIRECT |
6-phosphogluconate dehydrogenase C-terminal domain-like | 0.0003468 | DIRECT |
ACT-like | 0.002852 | INHERITED FROM: Prephenate dehydrogenase |
Thioesterase/thiol ester dehydrase-isomerase | 0.009323 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
Dehydroquinate synthase-like | 0.02946 | INHERITED FROM: Maleylacetate reductase |
Inosine monophosphate dehydrogenase (IMPDH) | 0.05026 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADH) |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.1893 | INHERITED FROM: Biliverdin reductase || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
Thiolase-like | 0.3997 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
alpha/beta-Hydrolases | 0.8751 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | INHERITED FROM: Fumarate reductase (NADH) |
FMN-linked oxidoreductases | 1 | INHERITED FROM: 12-oxophytodienoate reductase || tRNA-dihydrouridine(47) synthase (NAD(P)(+)) || tRNA-dihydrouridine(20) synthase (NAD(P)(+)) || Dihydropyrimidine dehydrogenase (NADP(+)) || Dihydroorotate dehydrogenase (NAD(+)) |
alpha-helical ferredoxin | 1 | INHERITED FROM: Dihydropyrimidine dehydrogenase (NADP(+)) || Dihydrouracil dehydrogenase (NAD(+)) |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
FAD/NAD(P)-binding domain | 1 | INHERITED FROM: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H) || Fumarate reductase (NADH) || Geranylgeranyl diphosphate reductase |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52151,51412 52151 - FabD/lysophospholipase-like 51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
51971,51395 51971 - Nucleotide-binding domain 51395 - FMN-linked oxidoreductases | 0 | DIRECT |
51735,75615 51735 - NAD(P)-binding Rossmann-fold domains 75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
48179,55021 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 55021 - ACT-like | 0 | DIRECT |
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like | 0 | DIRECT |
46548,51971 46548 - alpha-helical ferredoxin 51971 - Nucleotide-binding domain | 0 | DIRECT |
48600,51735 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51395,54862 51395 - FMN-linked oxidoreductases 54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
56176,56194 56176 - FAD-binding/transporter-associated domain-like 56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | DIRECT |
75615,53790 75615 - Siroheme synthase middle domains-like 53790 - Tetrapyrrole methylase | 0 | DIRECT |
51971,51971 51971 - Nucleotide-binding domain 51971 - Nucleotide-binding domain | 0.00000000000000176 | DIRECT |
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like | 0.00000000000004897 | DIRECT |
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.00000000000858 | DIRECT |
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.0000000001006 | DIRECT |
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.00000006466 | DIRECT |
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0000021 | DIRECT |
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.0003336 | DIRECT |
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.1879 | INHERITED FROM: Biliverdin reductase || Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
51905,56425 51905 - FAD/NAD(P)-binding domain 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | INHERITED FROM: Fumarate reductase (NADH) |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52151,51412 52151 - FabD/lysophospholipase-like 51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
51971,51395 51971 - Nucleotide-binding domain 51395 - FMN-linked oxidoreductases | 0 | Direct |
51735,75615 51735 - NAD(P)-binding Rossmann-fold domains 75615 - Siroheme synthase middle domains-like | 0 | Direct |
48179,55021 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 55021 - ACT-like | 0 | Direct |
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like | 0 | Direct |
46548,51971 46548 - alpha-helical ferredoxin 51971 - Nucleotide-binding domain | 0 | Direct |
48600,51735 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51395,54862 51395 - FMN-linked oxidoreductases 54862 - 4Fe-4S ferredoxins | 0 | Direct |
56176,56194 56176 - FAD-binding/transporter-associated domain-like 56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain | 0 | Direct |
75615,53790 75615 - Siroheme synthase middle domains-like 53790 - Tetrapyrrole methylase | 0 | Direct |
51971,51971 51971 - Nucleotide-binding domain 51971 - Nucleotide-binding domain | 0.00000000000000176 | Direct |
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like | 0.00000000000004897 | Direct |
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.00000000000858 | Direct |
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.0000000001006 | Direct |
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.00000006466 | Direct |
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.0000021 | Direct |
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.0003336 | Direct |
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.1879 | Inherited |
51905,56425 51905 - FAD/NAD(P)-binding domain 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51735,48179,55021 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 55021 - ACT-like | 0 | DIRECT |
46548,51971,51971 46548 - alpha-helical ferredoxin 51971 - Nucleotide-binding domain 51971 - Nucleotide-binding domain | 0 | DIRECT |
48600,51735,48179 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51971,51971,51395 51971 - Nucleotide-binding domain 51971 - Nucleotide-binding domain 51395 - FMN-linked oxidoreductases | 0 | DIRECT |
51735,75615,53790 51735 - NAD(P)-binding Rossmann-fold domains 75615 - Siroheme synthase middle domains-like 53790 - Tetrapyrrole methylase | 0 | DIRECT |
51971,51395,54862 51971 - Nucleotide-binding domain 51395 - FMN-linked oxidoreductases 54862 - 4Fe-4S ferredoxins | 0 | DIRECT |
50129,51735,50129 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like | 0.00000000000001807 | DIRECT |
51735,47336,53474 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.00000000000004331 | DIRECT |
50129,51735,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.0000000004727 | DIRECT |
51735,51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.0000000375 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51735,48179,55021 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 55021 - ACT-like | 0 | Direct |
46548,51971,51971 46548 - alpha-helical ferredoxin 51971 - Nucleotide-binding domain 51971 - Nucleotide-binding domain | 0 | Direct |
48600,51735,48179 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51971,51971,51395 51971 - Nucleotide-binding domain 51971 - Nucleotide-binding domain 51395 - FMN-linked oxidoreductases | 0 | Direct |
51735,75615,53790 51735 - NAD(P)-binding Rossmann-fold domains 75615 - Siroheme synthase middle domains-like 53790 - Tetrapyrrole methylase | 0 | Direct |
51971,51395,54862 51971 - Nucleotide-binding domain 51395 - FMN-linked oxidoreductases 54862 - 4Fe-4S ferredoxins | 0 | Direct |
50129,51735,50129 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like | 0.00000000000001807 | Direct |
51735,47336,53474 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.00000000000004331 | Direct |
50129,51735,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.0000000004727 | Direct |
51735,51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.0000000375 | Direct |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|