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  Home > Phenotype Ontology > With NAD(+) or NADP(+) as acceptor

Enzyme Commission (EC): With NAD(+) or NADP(+) as acceptor

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Oxidoreductases [1] <26>(213|314) (212|187|94)
+ 1:   Acting on the CH-NH group of donors [1.5] <8>(28|35) (28|14|4)
0:   With NAD(+) or NADP(+) as acceptor [1.5.1] <52>(17|21) (17|8|2)
- 1:   (NAD(P)H) [1.5.1.1](0|0) (0|0|0)
- 1:   1,2-dehydroreticulinium reductase (NADPH) [1.5.1.27](0|0) (0|0|0)
- 1:   1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) [1.5.1.21](1|0) (1|0|0)
- 1:   1-pyrroline-2-carboxylate reductase (NAD(P)H) [1.5.1.49](1|2) (1|0|0)
- 1:   2-methyl-1-pyrroline reductase [1.5.1.48](0|0) (0|0|0)
- 1:   6,7-dihydropteridine reductase [1.5.1.34](0|1) (0|0|0)
- 1:   8-hydroxy-5-deazaflavin:NADPH oxidoreductase [1.5.1.40](0|1) (0|0|0)
- 1:   Agroclavine dehydrogenase [1.5.1.46](0|0) (0|0|0)
- 1:   Alanopine dehydrogenase [1.5.1.17](0|0) (0|0|0)
- 1:   Berberine reductase [1.5.1.31](0|0) (0|0|0)
- 1:   Beta-alanopine dehydrogenase [1.5.1.26](0|0) (0|0|0)
- 1:   Carboxynorspermidine synthase [1.5.1.43](0|0) (0|0|0)
- 1:   D-lysopine dehydrogenase [1.5.1.16](0|0) (0|0|0)
- 1:   D-nopaline dehydrogenase [1.5.1.19](0|0) (0|0|0)
- 1:   D-octopine dehydrogenase [1.5.1.11](1|2) (1|1|0)
- 1:   Dihydrofolate reductase [1.5.1.3](3|4) (3|1|0)
- 1:   Dihydromethanopterin reductase (NAD(P)(+)) [1.5.1.47](0|0) (0|0|0)
- 1:   Dihydromonapterin reductase [1.5.1.50](0|1) (0|0|0)
- 1:   Ephedrine dehydrogenase [1.5.1.18](0|0) (0|0|0)
- 1:   FAD reductase (NAD(P)H) [1.5.1.45](0|0) (0|0|0)
- 1:   FAD reductase (NADH) [1.5.1.37](1|1) (1|0|0)
- 1:   FMN reductase (NAD(P)H) [1.5.1.39](0|0) (0|0|0)
- 1:   FMN reductase (NADH) [1.5.1.42](1|1) (1|0|0)
- 1:   FMN reductase (NADPH) [1.5.1.38](1|0) (1|0|0)
- 1:   Festuclavine dehydrogenase [1.5.1.44](0|0) (0|0|0)
- 1:   Flavin reductase (NADH) [1.5.1.36](1|1) (1|0|0)
- 1:   Flavin reductase (NADPH) [1.5.1.30](0|1) (0|0|0)
- 1:   Formyltetrahydrofolate dehydrogenase [1.5.1.6](4|3) (4|3|2)
- 1:   Methylenetetrahydrofolate dehydrogenase (NAD(+)) [1.5.1.15](0|0) (0|0|0)
- 1:   Methylenetetrahydrofolate dehydrogenase (NADP(+)) [1.5.1.5](2|2) (2|1|0)
- 1:   Methylenetetrahydrofolate reductase (NAD(P)H) [1.5.1.20](1|1) (1|0|0)
- 1:   N(5)-(carboxyethyl)ornithine synthase [1.5.1.24](1|1) (1|1|0)
- 1:   N-((2S)-2-amino-2-carboxyethyl)-L-glutamate dehydrogenase [1.5.1.51](0|0) (0|0|0)
- 1:   Opine dehydrogenase [1.5.1.28](0|0) (0|0|0)
- 1:   Pteridine reductase [1.5.1.33](0|0) (0|0|0)
- 1:   Pyrroline-5-carboxylate reductase [1.5.1.2](1|2) (1|1|0)
- 1:   Riboflavin reductase (NAD(P)H) [1.5.1.41](0|0) (0|0|0)
- 1:   Saccharopine dehydrogenase (NAD(+), L-glutamate-forming) [1.5.1.9](2|3) (2|1|0)
- 1:   Saccharopine dehydrogenase (NAD(+), L-lysine-forming) [1.5.1.7](1|1) (1|1|0)
- 1:   Saccharopine dehydrogenase (NADP(+), L-glutamate-forming) [1.5.1.10](1|2) (1|1|0)
- 1:   Saccharopine dehydrogenase (NADP(+), L-lysine-forming) [1.5.1.8](2|3) (2|1|0)
- 1:   Staphylopine dehydrogenase [1.5.1.52](0|0) (0|0|0)
- 1:   Strombine dehydrogenase [1.5.1.22](0|0) (0|0|0)
- 1:   Tauropine dehydrogenase [1.5.1.23](0|0) (0|0|0)
- 1:   Thiomorpholine-carboxylate dehydrogenase [1.5.1.25](0|1) (0|0|0)
- 1:   Transferred entry: 1.17.1.5 [1.5.1.13](0|0) (0|0|0)
- 1:   Transferred entry: 1.2.1.19 [1.5.1.35](0|0) (0|0|0)
- 1:   Transferred entry: 1.2.1.88 [1.5.1.12](0|0) (0|0|0)
- 1:   Transferred entry: 1.5.1.21 [1.5.1.14](0|0) (0|0|0)
- 1:   Transferred entry: 1.5.1.3 [1.5.1.4](0|0) (0|0|0)
- 1:   Transferred entry: 1.5.1.38, 1.5.1.39 and 1.5.1.41 [1.5.1.29](0|0) (0|0|0)
- 1:   Vomilenine reductase [1.5.1.32](0|0) (0|0|0)

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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Aminoacid dehydrogenase-like, N-terminal domain0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
Dihydrofolate reductase-like0Direct
NAD(P)-binding Rossmann-fold domains0Direct
FMN-binding split barrel0Direct
Thymidylate synthase/dCMP hydroxymethylase0.000000000001108Direct
L-sulfolactate dehydrogenase-like0.000000000009117Direct
Formate/glycerate dehydrogenase catalytic domain-like0.00000001318Direct
Electron transport accessory proteins0.000001207Direct
ACP-like0.00000727Direct
FMN-dependent nitroreductase-like0.000008673Direct
Flavoproteins0.00001328Direct
FMT C-terminal domain-like0.01833Inherited
Formyltransferase0.02193Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0.8464Inherited
ALDH-like1Inherited
FAD-linked oxidoreductase1Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ornithine cyclodeaminase-like0Direct
L-alanine dehydrogenase-like0Direct
Dihydrofolate reductases0Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0Direct
Tetrahydrofolate dehydrogenase/cyclohydrolase0Direct
N-(1-D-carboxylethyl)-L-norvaline dehydrogenase0Direct
NADH:FMN oxidoreductase-like0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Methylenetetrahydrofolate reductase0Direct
R67 dihydrofolate reductase0Direct
ProC C-terminal domain-like0Direct
Homoserine dehydrogenase-like0.00000000000003116Direct
Thymidylate synthase/dCMP hydroxymethylase0.00000000000246Direct
NADPH-dependent FMN reductase0.00000000003219Direct
L-sulfolactate dehydrogenase-like0.0000000003147Direct
Tyrosine-dependent oxidoreductases0.00000009384Direct
NADH oxidase/flavin reductase0.0001567Direct
Post formyltransferase domain0.02133Inherited
Formyltransferase0.027Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0.7862Inherited
ALDH-like1Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
Dihydrofolate reductase-like0Direct
FMN-binding split barrel0Direct
NAD(P)-binding Rossmann-fold domains0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Thymidylate synthase/dCMP hydroxymethylase0.0000000000007947Direct
L-sulfolactate dehydrogenase-like0.000000000006589Direct
Formate/glycerate dehydrogenase catalytic domain-like0.00000000997Direct
Electron transport accessory proteins0.0000009404Direct
ACP-like0.000005728Direct
FMN-dependent nitroreductase-like0.000006845Direct
Flavoproteins0.00001053Direct
FMT C-terminal domain-like0.01564Inherited
Formyltransferase0.01876Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0.7803Inherited
FAD-linked oxidoreductase1Inherited
ALDH-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47336,53720
  • 47336 - ACP-like
  • 53720 - ALDH-like
    		• 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0Direct
    50486,47336
  • 50486 - FMT C-terminal domain-like
  • 47336 - ACP-like
    		• 0Direct
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
    		• 0Direct
    53597,55831
  • 53597 - Dihydrofolate reductase-like
  • 55831 - Thymidylate synthase/dCMP hydroxymethylase
    		• 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0.00004086Direct
    53328,50486
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
    		• 0.01391Inherited
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
    		• 0.7786Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50486,47336,53720
  • 50486 - FMT C-terminal domain-like
  • 47336 - ACP-like
  • 53720 - ALDH-like
    		• 0Direct
    53328,50486,47336
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 47336 - ACP-like
    		• 0Direct

    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)
    Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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