Enzyme Commission (EC): Acting on a sulfur group of donors

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: root [root] <7>

+ 1: Oxidoreductases [1] <26> (213|314) (212|187|94)

0: Acting on a sulfur group of donors [1.8] <9> (29|28) (30|21|9)

- 1: With NAD(+) or NADP(+) as acceptor [1.8.1] <21> (11|12) (12|9|6)

- 1: With a disulfide as acceptor [1.8.4] <14> (4|5) (4|3|1)

- 1: With a quinone or similar compound as acceptor [1.8.5] <8> (5|4) (5|3|0)

- 1: With oxygen as acceptor [1.8.3] <7> (8|5) (8|2|1)

- 1: With a cytochrome as acceptor [1.8.2] <6> (1|0) (1|1|0)

- 1: With other, known, acceptors [1.8.98] <6> (4|1) (4|1|0)

- 1: With other acceptors [1.8.99] <5> (3|3) (3|2|1)

- 1: With an iron-sulfur protein as acceptor [1.8.7] <3> (6|3) (6|3|2)

- 1: With an nitrogenous group as acceptor [1.8.6] <1> (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Thioredoxin-like	0	Direct
Mss4-like	0	Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	0	Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
Adenine nucleotide alpha hydrolases-like	0	Direct
Nitrite/Sulfite reductase N-terminal domain-like	0	Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	Direct
Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
FAD/NAD(P)-binding domain	0	Direct
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)	0	Direct
Peptide methionine sulfoxide reductase	0	Direct
FAD-dependent thiol oxidase	0	Direct
GST C-terminal domain-like	0.000000000000001017	Direct
ParB/Sulfiredoxin	0.000000000000007489	Direct
Riboflavin synthase domain-like	0.000000000000244	Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.000000000000421	Direct
C-type lectin-like	0.0000006406	Direct
Flavoproteins	0.000001466	Direct
Respiratory nitrate reductase 1 gamma chain	0.000008081	Direct
Oxidoreductase molybdopterin-binding domain	0.0008008	Direct
Cysteine-rich domain	0.001072	Inherited
alpha-helical ferredoxin	0.007167	Inherited
Cytochrome c	0.01812	Inherited
E set domains	0.06477	Inherited
Nucleotide-binding domain	0.07499	Inherited
Cytochrome b5-like heme/steroid binding domain	0.1864	Inherited
ADC-like	0.307	Inherited
4Fe-4S ferredoxins	0.3341	Inherited
Formate dehydrogenase/DMSO reductase, domains 1-3	0.4288	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
Peptide methionine sulfoxide reductase	0	Direct
NADPH-cytochrome p450 reductase-like	0	Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	Direct
Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
Sulfiredoxin-like	0	Direct
FAD-dependent thiol oxidase	0	Direct
PAPS reductase-like	0	Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	0	Direct
Thioltransferase	0	Direct
SelR domain	0	Direct
Duplicated SiR/NiR-like domains 1 and 3	0	Direct
DsrA/DsrB N-terminal-domain-like	0	Direct
Cytochrome p450 reductase N-terminal domain-like	0	Direct
C1-like domain	0	Direct
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)	0	Direct
FAD/NAD-linked reductases, N-terminal and central domains	0	Direct
Glutathione S-transferase (GST), N-terminal domain	0.000000000001552	Direct
Glutathione S-transferase (GST), C-terminal domain	0.00000000002744	Direct
Sulfatase-modifying factor-like	0.0000006219	Direct
Oxidoreductase molybdopterin-binding domain	0.000812	Direct
Molybdenum-containing oxidoreductases-like dimerisation domain	0.0009628	Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain II	0.003717	Inherited
Ferredoxin domains from multidomain proteins	0.098	Inherited
Cytochrome b5	0.1583	Inherited
Formate dehydrogenase/DMSO reductase, C-terminal domain	0.4225	Inherited
Formate dehydrogenase/DMSO reductase, domains 1-3	0.4278	Inherited
Glutathione peroxidase-like	0.7348	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Adenine nucleotide alpha hydrolases-like	0	Direct
Nitrite/Sulfite reductase N-terminal domain-like	0	Direct
Peptide methionine sulfoxide reductase	0	Direct
FAD-dependent thiol oxidase	0	Direct
Thioredoxin-like	0	Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain	0	Direct
Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
Mss4-like	0	Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	Direct
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)	0	Direct
FAD/NAD(P)-binding domain	0	Direct
GST C-terminal domain-like	7.073e-16	Direct
ParB/Sulfiredoxin	0.000000000000005248	Direct
Riboflavin synthase domain-like	0.0000000000001737	Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.0000000000003007	Direct
C-type lectin-like	0.0000004973	Direct
Flavoproteins	0.000001145	Direct
Respiratory nitrate reductase 1 gamma chain	0.000006375	Direct
Oxidoreductase molybdopterin-binding domain	0.0006584	Direct
Cysteine-rich domain	0.000884	Direct
alpha-helical ferredoxin	0.006039	Inherited
Cytochrome c	0.01545	Inherited
E set domains	0.05618	Inherited
Nucleotide-binding domain	0.06513	Inherited
Cytochrome b5-like heme/steroid binding domain	0.1648	Inherited
ADC-like	0.277	Inherited
4Fe-4S ferredoxins	0.3019	Inherited
Formate dehydrogenase/DMSO reductase, domains 1-3	0.3897	Inherited
TK C-terminal domain-like	0.6609	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55124,54862 55124 - Nitrite/Sulfite reductase N-terminal domain-like 54862 - 4Fe-4S ferredoxins	0	Direct
55124,56014 55124 - Nitrite/Sulfite reductase N-terminal domain-like 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
55068,51316 55068 - Peptide methionine sulfoxide reductase 51316 - Mss4-like	0	Direct
52402,52833 52402 - Adenine nucleotide alpha hydrolases-like 52833 - Thioredoxin-like	0	Direct
55856,56524 55856 - Cytochrome b5-like heme/steroid binding domain 56524 - Oxidoreductase molybdopterin-binding domain	0	Direct
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
52833,57889 52833 - Thioredoxin-like 57889 - Cysteine-rich domain	0	Direct
51905,52833 51905 - FAD/NAD(P)-binding domain 52833 - Thioredoxin-like	0	Direct
51905,54862 51905 - FAD/NAD(P)-binding domain 54862 - 4Fe-4S ferredoxins	0	Direct
56014,55124 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like 55124 - Nitrite/Sulfite reductase N-terminal domain-like	0	Direct
52833,55068 52833 - Thioredoxin-like 55068 - Peptide methionine sulfoxide reductase	0	Direct
52218,63380 52218 - Flavoproteins 63380 - Riboflavin synthase domain-like	0	Direct
54862,56014 54862 - 4Fe-4S ferredoxins 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	5.316e-16	Direct
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0.0000000000000263	Direct
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.000000000001766	Direct
51971,51905 51971 - Nucleotide-binding domain 51905 - FAD/NAD(P)-binding domain	0.00001126	Direct
46626,46626 46626 - Cytochrome c 46626 - Cytochrome c	0.0001874	Direct
56524,81296 56524 - Oxidoreductase molybdopterin-binding domain 81296 - E set domains	0.0006584	Direct
53706,50692 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3 50692 - ADC-like	0.2405	Inherited
51905,51905 51905 - FAD/NAD(P)-binding domain 51905 - FAD/NAD(P)-binding domain	0.5861	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
51971,51905,55424 51971 - Nucleotide-binding domain 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	Direct
55124,56014,55124 55124 - Nitrite/Sulfite reductase N-terminal domain-like 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like 55124 - Nitrite/Sulfite reductase N-terminal domain-like	0	Direct
55124,54862,56014 55124 - Nitrite/Sulfite reductase N-terminal domain-like 54862 - 4Fe-4S ferredoxins 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
56014,55124,56014 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like 55124 - Nitrite/Sulfite reductase N-terminal domain-like 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like	0	Direct
52833,52833,57889 52833 - Thioredoxin-like 52833 - Thioredoxin-like 57889 - Cysteine-rich domain	0	Direct
52833,55068,51316 52833 - Thioredoxin-like 55068 - Peptide methionine sulfoxide reductase 51316 - Mss4-like	0	Direct
52218,63380,52343 52218 - Flavoproteins 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0	Direct
55856,56524,81296 55856 - Cytochrome b5-like heme/steroid binding domain 56524 - Oxidoreductase molybdopterin-binding domain 81296 - E set domains	0	Direct
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.000000003024	Direct

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Enzyme Commission (EC): Acting on a sulfur group of donors

Superfamily

Family

Supra-domain (including individual superfamily)