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Enzyme Commission (EC): Transferring one-carbon groups
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Methylglyoxal synthase-like | 0 | DIRECT |
| NusB-like | 0 | DIRECT |
| Ada DNA repair protein, N-terminal domain (N-Ada 10) | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
| Putative methyltransferase TM0872, insert domain | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Methionine synthase activation domain-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Methionine synthase domain | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Monomethylamine methyltransferase MtmB | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| RuBisCo LSMT C-terminal, substrate-binding domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| FMT C-terminal domain-like | 0 | DIRECT |
| Thymidylate synthase-complementing protein Thy1 | 0 | DIRECT |
| Folate-binding domain | 0 | DIRECT |
| Cytidine deaminase-like | 0 | DIRECT |
| Formyltransferase | 0 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
| Thymidylate synthase/dCMP hydroxymethylase | 0 | DIRECT |
| Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 0 | DIRECT |
| SSo0622-like | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Methylated DNA-protein cysteine methyltransferase domain | 0 | DIRECT |
| Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0 | DIRECT |
| Aspartate/ornithine carbamoyltransferase | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | DIRECT |
| CbiD-like | 0 | DIRECT |
| Cobalamin (vitamin B12)-binding domain | 0.000000002221 | DIRECT |
| RNA-binding domain, RBD | 0.000000003457 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.00000002225 | DIRECT |
| PLP-dependent transferases | 0.00000002587 | DIRECT |
| Dihydropteroate synthetase-like | 0.00000198 | DIRECT |
| HMG-box | 0.000003707 | DIRECT |
| Galactose oxidase, central domain | 0.00002736 | DIRECT |
| Chromo domain-like | 0.0001855 | DIRECT |
| Dihydrofolate reductase-like | 0.0004394 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0.0009382 | DIRECT |
| Kelch motif | 0.002045 | INHERITED FROM: Methyltransferases || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase |
| Nucleotide-binding domain | 0.004332 | INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase || Methyltransferases |
| CYTH-like phosphatases | 0.009136 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase |
| Radical SAM enzymes | 0.01073 | INHERITED FROM: Methyltransferases || 23S rRNA (adenine(2503)-C(8))-methyltransferase || 23S rRNA (adenine(2503)-C(2))-methyltransferase |
| Tudor/PWWP/MBT | 0.07412 | INHERITED FROM: DNA (cytosine-5-)-methyltransferase |
| "Winged helix" DNA-binding domain | 0.3415 | INHERITED FROM: Isoflavone 4'-O-methyltransferase || 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase || Methyltransferases || (S)-scoulerine 9-O-methyltransferase || Flavone 3'-O-methyltransferase || Acetylserotonin O-methyltransferase || 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase || (RS)-norcoclaurine 6-O-methyltransferase || (Iso)eugenol O-methyltransferase || Caffeate O-methyltransferase || Isoflavone 7-O-methyltransferase || 6-hydroxytryprostatin B O-methyltransferase |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3769 | INHERITED FROM: tRNA (guanine(37)-N(1))-methyltransferase |
| Homeodomain-like | 0.5774 | INHERITED FROM: Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase |
| Trypsin-like serine proteases | 0.6723 | INHERITED FROM: Methyltransferase cap1 || mRNA (guanine-N(7)-)-methyltransferase |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0.9751 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: 23S rRNA (uracil(1939)-C(5))-methyltransferase |
| PUA domain-like | 1 | INHERITED FROM: 23S rRNA (cytosine(1962)-C(5))-methyltransferase || Methyltransferases || 16S rRNA (uracil(1498)-N(3))-methyltransferase |
| Carbamoyl phosphate synthetase, large subunit connection domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Malonyl-[acyl-carrier protein] O-methyltransferase |
| SH3-domain | 1 | INHERITED FROM: Type I protein arginine methyltransferase |
| FYVE/PHD zinc finger | 1 | INHERITED FROM: [Histone H3]-lysine(4) N-trimethyltransferase || DNA (cytosine-5-)-methyltransferase |
| WW domain | 1 | INHERITED FROM: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase |
| Clavaminate synthase-like | 1 | INHERITED FROM: tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase || tRNA (carboxymethyluridine(34)-5-O)-methyltransferase |
| lambda repressor-like DNA-binding domains | 1 | INHERITED FROM: DNA (cytosine-5-)-methyltransferase |
| E set domains | 1 | INHERITED FROM: Methyltransferases || Methyltransferase cap1 || mRNA (guanine-N(7)-)-methyltransferase |
| PurM C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| TPR-like | 1 | INHERITED FROM: Type II protein arginine methyltransferase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| HD-domain/PDEase-like | 1 | INHERITED FROM: tRNA (cytidine(56)-2'-O)-methyltransferase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Methyltransferase cap1 || mRNA (guanine-N(7)-)-methyltransferase |
| PurM N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| Pentein | 1 | INHERITED FROM: Amidinotransferases |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Uroporphyrinogen-III C-methyltransferase || UDP-4-amino-4-deoxy-L-arabinose formyltransferase |
| DNA/RNA polymerases | 1 | INHERITED FROM: Methyltransferase cap1 || mRNA (guanine-N(7)-)-methyltransferase |
| THUMP domain-like | 1 | INHERITED FROM: tRNA (guanine(10)-N(2))-dimethyltransferase || tRNA (guanine(6)-N(2))-methyltransferase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Methylglyoxal synthase-like | 0 | Direct |
| NusB-like | 0 | Direct |
| Ada DNA repair protein, N-terminal domain (N-Ada 10) | 0 | Direct |
| L30e-like | 0 | Direct |
| S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
| Putative methyltransferase TM0872, insert domain | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| Methionine synthase activation domain-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Methionine synthase domain | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Monomethylamine methyltransferase MtmB | 0 | Direct |
| SET domain | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| RuBisCo LSMT C-terminal, substrate-binding domain | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| FMT C-terminal domain-like | 0 | Direct |
| Thymidylate synthase-complementing protein Thy1 | 0 | Direct |
| Folate-binding domain | 0 | Direct |
| Cytidine deaminase-like | 0 | Direct |
| Formyltransferase | 0 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
| Thymidylate synthase/dCMP hydroxymethylase | 0 | Direct |
| Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 0 | Direct |
| SSo0622-like | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Methylated DNA-protein cysteine methyltransferase domain | 0 | Direct |
| Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0 | Direct |
| Aspartate/ornithine carbamoyltransferase | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | Direct |
| CbiD-like | 0 | Direct |
| Cobalamin (vitamin B12)-binding domain | 0.000000002221 | Direct |
| RNA-binding domain, RBD | 0.000000003457 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.00000002225 | Direct |
| PLP-dependent transferases | 0.00000002587 | Direct |
| Dihydropteroate synthetase-like | 0.00000198 | Direct |
| HMG-box | 0.000003707 | Direct |
| Galactose oxidase, central domain | 0.00002736 | Direct |
| Chromo domain-like | 0.0001855 | Direct |
| Dihydrofolate reductase-like | 0.0004394 | Direct |
| FAD-linked reductases, C-terminal domain | 0.0009382 | Direct |
| Kelch motif | 0.002045 | Inherited |
| Nucleotide-binding domain | 0.004332 | Inherited |
| CYTH-like phosphatases | 0.009136 | Inherited |
| Radical SAM enzymes | 0.01073 | Inherited |
| Tudor/PWWP/MBT | 0.07412 | Inherited |
| "Winged helix" DNA-binding domain | 0.3415 | Inherited |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3769 | Inherited |
| Homeodomain-like | 0.5774 | Inherited |
| Trypsin-like serine proteases | 0.6723 | Inherited |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0.9751 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| PUA domain-like | 1 | Inherited |
| Carbamoyl phosphate synthetase, large subunit connection domain | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| SH3-domain | 1 | Inherited |
| FYVE/PHD zinc finger | 1 | Inherited |
| WW domain | 1 | Inherited |
| Clavaminate synthase-like | 1 | Inherited |
| lambda repressor-like DNA-binding domains | 1 | Inherited |
| E set domains | 1 | Inherited |
| PurM C-terminal domain-like | 1 | Inherited |
| Rudiment single hybrid motif | 1 | Inherited |
| TPR-like | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| PurM N-terminal domain-like | 1 | Inherited |
| Pentein | 1 | Inherited |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| DNA/RNA polymerases | 1 | Inherited |
| THUMP domain-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Guanidinoacetate methyltransferase | 0 | DIRECT |
| hypothetical RNA methyltransferase | 0 | DIRECT |
| Chemotaxis receptor methyltransferase CheR, C-terminal domain | 0 | DIRECT |
| YhiQ-like | 0 | DIRECT |
| mRNA cap (Guanine N-7) methyltransferase | 0 | DIRECT |
| AD-003 protein-like | 0 | DIRECT |
| Glucose-inhibited division protein B (GidB) | 0 | DIRECT |
| N-6 DNA Methylase-like | 0 | DIRECT |
| Plant O-methyltransferase, N-terminal domain | 0 | DIRECT |
| YhhF-like | 0 | DIRECT |
| Amidinotransferase | 0 | DIRECT |
| Plant O-methyltransferase, C-terminal domain | 0 | DIRECT |
| TrmB-like | 0 | DIRECT |
| TRM1-like | 0 | DIRECT |
| Putative methyltransferase TM0872, insert domain | 0 | DIRECT |
| RmsB N-terminal domain-like | 0 | DIRECT |
| tRNA(1-methyladenosine) methyltransferase-like | 0 | DIRECT |
| AF0751-like | 0 | DIRECT |
| Glycine N-methyltransferase | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| Salicylic acid carboxyl methyltransferase (SAMT) | 0 | DIRECT |
| Histone lysine methyltransferases | 0 | DIRECT |
| YbeA-like | 0 | DIRECT |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | DIRECT |
| RNA helicase | 0 | DIRECT |
| rRNA adenine dimethylase-like | 0 | DIRECT |
| RNA methyltransferase FtsJ | 0 | DIRECT |
| Ketopantoate hydroxymethyltransferase PanB | 0 | DIRECT |
| Type II DNA methylase | 0 | DIRECT |
| Thiopurine S-methyltransferase | 0 | DIRECT |
| Thymidylate synthase-complementing protein Thy1 | 0 | DIRECT |
| PWWP domain | 0 | DIRECT |
| CbiD-like | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Post formyltransferase domain | 0 | DIRECT |
| Hypothetical protein MJ0882 | 0 | DIRECT |
| Leucine carboxy methyltransferase Ppm1 | 0 | DIRECT |
| Protein-L-isoaspartyl O-methyltransferase | 0 | DIRECT |
| Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 0 | DIRECT |
| AF1056-like | 0 | DIRECT |
| Monomethylamine methyltransferase MtmB | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Methionine synthase SAM-binding domain | 0 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
| Cobalamin-independent methionine synthase | 0 | DIRECT |
| Class II viral fusion proteins C-terminal domain | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| Met-10+ protein-like | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| N6 adenine-specific DNA methylase, DAM | 0 | DIRECT |
| (Uracil-5-)-methyltransferase | 0 | DIRECT |
| Histamine methyltransferase | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Mycolic acid cyclopropane synthase | 0 | DIRECT |
| Formyltransferase | 0 | DIRECT |
| N5-glutamine methyltransferase, HemK | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Ada DNA repair protein, N-terminal domain (N-Ada 10) | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| SpoU-like RNA 2'-O ribose methyltransferase | 0 | DIRECT |
| Methylated DNA-protein cysteine methyltransferase domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Aspartate/ornithine carbamoyltransferase | 0 | DIRECT |
| RPA4359-like | 0 | DIRECT |
| Precorrin-6Y methyltransferase (CbiT) | 0 | DIRECT |
| SSo0622-like | 0 | DIRECT |
| Methionine synthase domain | 0 | DIRECT |
| AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC | 0 | DIRECT |
| Siroheme synthase N-terminal domain-like | 0 | DIRECT |
| Methyltransferase 10 domain | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| Thymidylate synthase/dCMP hydroxymethylase | 0 | DIRECT |
| RuBisCo LSMT C-terminal, substrate-binding domain | 0 | DIRECT |
| Inosicase | 0 | DIRECT |
| Aminomethyltransferase folate-binding domain | 0 | DIRECT |
| Hypothetical RNA methyltransferase domain (HRMD) | 0 | DIRECT |
| Methyltetrahydrofolate-utiluzing methyltransferases | 0 | DIRECT |
| MraW-like putative methyltransferases | 0 | DIRECT |
| mRNA cap methylase | 0 | DIRECT |
| Arylamine N-methyltransferase | 0 | DIRECT |
| YggJ N-terminal domain-like | 0 | DIRECT |
| RNA 2'-O ribose methyltransferase substrate binding domain | 0 | DIRECT |
| TRAM domain | 0 | DIRECT |
| DNA methylase TaqI, N-terminal domain | 0 | DIRECT |
| tRNA(m1G37)-methyltransferase TrmD | 0 | DIRECT |
| Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0 | DIRECT |
| UbiE/COQ5-like | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| YggJ C-terminal domain-like | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| RuBisCo LSMT catalytic domain | 0 | DIRECT |
| Chromo domain | 0.000000000001845 | DIRECT |
| Viral proteases | 0.00000000002957 | DIRECT |
| Cobalamin (vitamin B12)-binding domain | 0.0000000001835 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.000000009579 | DIRECT |
| HMG-box | 0.000001951 | DIRECT |
| Dihydrofolate reductases | 0.000008944 | DIRECT |
| Canonical RBD | 0.00008862 | DIRECT |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0.0001382 | DIRECT |
| AlkB-like | 0.01953 | INHERITED FROM: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0.7434 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| RNA-dependent RNA-polymerase | 0.77 | INHERITED FROM: Methyltransferases || Methyltransferase cap1 || mRNA (guanine-N(7)-)-methyltransferase |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0.8265 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| Biotin biosynthesis protein BioH | 0.8977 | INHERITED FROM: Malonyl-[acyl-carrier protein] O-methyltransferase |
| PHD domain | 0.9853 | INHERITED FROM: [Histone H3]-lysine(4) N-trimethyltransferase |
| Carbamoyl phosphate synthetase, large subunit connection domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| PurM N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| BC C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| PurM C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: UDP-4-amino-4-deoxy-L-arabinose formyltransferase || Hydroxymethyl-, formyl- and related transferases |
| WW domain | 1 | INHERITED FROM: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase |
| BC N-terminal domain-like | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Phosphoribosylglycinamide formyltransferase |
| Uroporphyrinogen decarboxylase, UROD | 1 | INHERITED FROM: methyltransferase |
| SH3-domain | 1 | INHERITED FROM: Type I protein arginine methyltransferase |
| Spermidine synthase | 1 | INHERITED FROM: Putrescine N-methyltransferase |
| MoCo biosynthesis proteins | 1 | INHERITED FROM: 23S rRNA (adenine(2503)-C(2))-methyltransferase |
| BC ATP-binding domain-like | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Phosphoribosylglycinamide formyltransferase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Guanidinoacetate methyltransferase | 0 | Direct |
| hypothetical RNA methyltransferase | 0 | Direct |
| Chemotaxis receptor methyltransferase CheR, C-terminal domain | 0 | Direct |
| YhiQ-like | 0 | Direct |
| mRNA cap (Guanine N-7) methyltransferase | 0 | Direct |
| AD-003 protein-like | 0 | Direct |
| Glucose-inhibited division protein B (GidB) | 0 | Direct |
| N-6 DNA Methylase-like | 0 | Direct |
| Plant O-methyltransferase, N-terminal domain | 0 | Direct |
| YhhF-like | 0 | Direct |
| Amidinotransferase | 0 | Direct |
| Plant O-methyltransferase, C-terminal domain | 0 | Direct |
| TrmB-like | 0 | Direct |
| TRM1-like | 0 | Direct |
| Putative methyltransferase TM0872, insert domain | 0 | Direct |
| RmsB N-terminal domain-like | 0 | Direct |
| tRNA(1-methyladenosine) methyltransferase-like | 0 | Direct |
| AF0751-like | 0 | Direct |
| Glycine N-methyltransferase | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| Salicylic acid carboxyl methyltransferase (SAMT) | 0 | Direct |
| Histone lysine methyltransferases | 0 | Direct |
| YbeA-like | 0 | Direct |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | Direct |
| RNA helicase | 0 | Direct |
| rRNA adenine dimethylase-like | 0 | Direct |
| RNA methyltransferase FtsJ | 0 | Direct |
| Ketopantoate hydroxymethyltransferase PanB | 0 | Direct |
| Type II DNA methylase | 0 | Direct |
| Thiopurine S-methyltransferase | 0 | Direct |
| Thymidylate synthase-complementing protein Thy1 | 0 | Direct |
| PWWP domain | 0 | Direct |
| CbiD-like | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Post formyltransferase domain | 0 | Direct |
| Hypothetical protein MJ0882 | 0 | Direct |
| Leucine carboxy methyltransferase Ppm1 | 0 | Direct |
| Protein-L-isoaspartyl O-methyltransferase | 0 | Direct |
| Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 0 | Direct |
| AF1056-like | 0 | Direct |
| Monomethylamine methyltransferase MtmB | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Methionine synthase SAM-binding domain | 0 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
| Cobalamin-independent methionine synthase | 0 | Direct |
| Class II viral fusion proteins C-terminal domain | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| Met-10+ protein-like | 0 | Direct |
| COMT-like | 0 | Direct |
| N6 adenine-specific DNA methylase, DAM | 0 | Direct |
| (Uracil-5-)-methyltransferase | 0 | Direct |
| Histamine methyltransferase | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| Mycolic acid cyclopropane synthase | 0 | Direct |
| Formyltransferase | 0 | Direct |
| N5-glutamine methyltransferase, HemK | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Ada DNA repair protein, N-terminal domain (N-Ada 10) | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| SpoU-like RNA 2'-O ribose methyltransferase | 0 | Direct |
| Methylated DNA-protein cysteine methyltransferase domain | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Aspartate/ornithine carbamoyltransferase | 0 | Direct |
| RPA4359-like | 0 | Direct |
| Precorrin-6Y methyltransferase (CbiT) | 0 | Direct |
| SSo0622-like | 0 | Direct |
| Methionine synthase domain | 0 | Direct |
| AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC | 0 | Direct |
| Siroheme synthase N-terminal domain-like | 0 | Direct |
| Methyltransferase 10 domain | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| Thymidylate synthase/dCMP hydroxymethylase | 0 | Direct |
| RuBisCo LSMT C-terminal, substrate-binding domain | 0 | Direct |
| Inosicase | 0 | Direct |
| Aminomethyltransferase folate-binding domain | 0 | Direct |
| Hypothetical RNA methyltransferase domain (HRMD) | 0 | Direct |
| Methyltetrahydrofolate-utiluzing methyltransferases | 0 | Direct |
| MraW-like putative methyltransferases | 0 | Direct |
| mRNA cap methylase | 0 | Direct |
| Arylamine N-methyltransferase | 0 | Direct |
| YggJ N-terminal domain-like | 0 | Direct |
| RNA 2'-O ribose methyltransferase substrate binding domain | 0 | Direct |
| TRAM domain | 0 | Direct |
| DNA methylase TaqI, N-terminal domain | 0 | Direct |
| tRNA(m1G37)-methyltransferase TrmD | 0 | Direct |
| Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0 | Direct |
| UbiE/COQ5-like | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| YggJ C-terminal domain-like | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| RuBisCo LSMT catalytic domain | 0 | Direct |
| Chromo domain | 0.000000000001845 | Direct |
| Viral proteases | 0.00000000002957 | Direct |
| Cobalamin (vitamin B12)-binding domain | 0.0000000001835 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.000000009579 | Direct |
| HMG-box | 0.000001951 | Direct |
| Dihydrofolate reductases | 0.000008944 | Direct |
| Canonical RBD | 0.00008862 | Direct |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0.0001382 | Direct |
| AlkB-like | 0.01953 | Inherited |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0.7434 | Inherited |
| RNA-dependent RNA-polymerase | 0.77 | Inherited |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0.8265 | Inherited |
| Biotin biosynthesis protein BioH | 0.8977 | Inherited |
| PHD domain | 0.9853 | Inherited |
| Carbamoyl phosphate synthetase, large subunit connection domain | 1 | Inherited |
| PurM N-terminal domain-like | 1 | Inherited |
| BC C-terminal domain-like | 1 | Inherited |
| PurM C-terminal domain-like | 1 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| WW domain | 1 | Inherited |
| BC N-terminal domain-like | 1 | Inherited |
| Uroporphyrinogen decarboxylase, UROD | 1 | Inherited |
| SH3-domain | 1 | Inherited |
| Spermidine synthase | 1 | Inherited |
| MoCo biosynthesis proteins | 1 | Inherited |
| BC ATP-binding domain-like | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| L30e-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Methionine synthase activation domain-like | 0 | DIRECT |
| Ada DNA repair protein, N-terminal domain (N-Ada 10) | 0 | DIRECT |
| Folate-binding domain | 0 | DIRECT |
| Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Formyltransferase | 0 | DIRECT |
| NusB-like | 0 | DIRECT |
| Methylated DNA-protein cysteine methyltransferase domain | 0 | DIRECT |
| Cytidine deaminase-like | 0 | DIRECT |
| Putative methyltransferase TM0872, insert domain | 0 | DIRECT |
| Monomethylamine methyltransferase MtmB | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
| Thymidylate synthase/dCMP hydroxymethylase | 0 | DIRECT |
| Methionine synthase domain | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Thymidylate synthase-complementing protein Thy1 | 0 | DIRECT |
| RuBisCo LSMT C-terminal, substrate-binding domain | 0 | DIRECT |
| Aspartate/ornithine carbamoyltransferase | 0 | DIRECT |
| SSo0622-like | 0 | DIRECT |
| S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
| CbiD-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| FMT C-terminal domain-like | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Cobalamin (vitamin B12)-binding domain | 0.00000000166 | DIRECT |
| RNA-binding domain, RBD | 0.00000000259 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.00000001686 | DIRECT |
| PLP-dependent transferases | 0.00000001963 | DIRECT |
| Dihydropteroate synthetase-like | 0.000001552 | DIRECT |
| HMG-box | 0.000002915 | DIRECT |
| Galactose oxidase, central domain | 0.00002182 | DIRECT |
| Chromo domain-like | 0.0001503 | DIRECT |
| Dihydrofolate reductase-like | 0.0003587 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0.0007729 | DIRECT |
| Kelch motif | 0.001701 | INHERITED FROM: Methyltransferases || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase |
| Nucleotide-binding domain | 0.003629 | INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase || Methyltransferases |
| CYTH-like phosphatases | 0.007729 | INHERITED FROM: Methyltransferases || mRNA (guanine-N(7)-)-methyltransferase |
| Radical SAM enzymes | 0.009096 | INHERITED FROM: 23S rRNA (adenine(2503)-C(8))-methyltransferase || Methyltransferases || 23S rRNA (adenine(2503)-C(2))-methyltransferase |
| Tudor/PWWP/MBT | 0.06436 | INHERITED FROM: DNA (cytosine-5-)-methyltransferase |
| "Winged helix" DNA-binding domain | 0.3086 | INHERITED FROM: Isoflavone 4'-O-methyltransferase || 6-hydroxytryprostatin B O-methyltransferase || Flavone 3'-O-methyltransferase || Methyltransferases || (S)-scoulerine 9-O-methyltransferase || Isoflavone 7-O-methyltransferase || (Iso)eugenol O-methyltransferase || (RS)-norcoclaurine 6-O-methyltransferase || Acetylserotonin O-methyltransferase || Caffeate O-methyltransferase || 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase || 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3413 | INHERITED FROM: tRNA (guanine(37)-N(1))-methyltransferase |
| Homeodomain-like | 0.5295 | INHERITED FROM: Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase |
| Trypsin-like serine proteases | 0.6177 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase || Methyltransferase cap1 |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0.9024 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| FYVE/PHD zinc finger | 0.9414 | INHERITED FROM: [Histone H3]-lysine(4) N-trimethyltransferase || DNA (cytosine-5-)-methyltransferase |
| lambda repressor-like DNA-binding domains | 0.9837 | INHERITED FROM: DNA (cytosine-5-)-methyltransferase |
| PreATP-grasp domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Phosphoribosylglycinamide formyltransferase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| E set domains | 1 | INHERITED FROM: Methyltransferases || mRNA (guanine-N(7)-)-methyltransferase || Methyltransferase cap1 |
| Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| TPR-like | 1 | INHERITED FROM: Type II protein arginine methyltransferase |
| Carbamoyl phosphate synthetase, large subunit connection domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Malonyl-[acyl-carrier protein] O-methyltransferase |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: UDP-4-amino-4-deoxy-L-arabinose formyltransferase || Uroporphyrinogen-III C-methyltransferase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase || Methyltransferase cap1 |
| PUA domain-like | 1 | INHERITED FROM: 16S rRNA (uracil(1498)-N(3))-methyltransferase || Methyltransferases || 23S rRNA (cytosine(1962)-C(5))-methyltransferase |
| SH3-domain | 1 | INHERITED FROM: Type I protein arginine methyltransferase |
| Pentein | 1 | INHERITED FROM: Amidinotransferases |
| Clavaminate synthase-like | 1 | INHERITED FROM: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase |
| PurM C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| THUMP domain-like | 1 | INHERITED FROM: tRNA (guanine(10)-N(2))-dimethyltransferase || tRNA (guanine(6)-N(2))-methyltransferase |
| PurM N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
| HD-domain/PDEase-like | 1 | INHERITED FROM: tRNA (cytidine(56)-2'-O)-methyltransferase |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: 23S rRNA (uracil(1939)-C(5))-methyltransferase |
| DNA/RNA polymerases | 1 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase || Methyltransferase cap1 |
| WW domain | 1 | INHERITED FROM: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| L30e-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Methionine synthase activation domain-like | 0 | Direct |
| Ada DNA repair protein, N-terminal domain (N-Ada 10) | 0 | Direct |
| Folate-binding domain | 0 | Direct |
| Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Formyltransferase | 0 | Direct |
| NusB-like | 0 | Direct |
| Methylated DNA-protein cysteine methyltransferase domain | 0 | Direct |
| Cytidine deaminase-like | 0 | Direct |
| Putative methyltransferase TM0872, insert domain | 0 | Direct |
| Monomethylamine methyltransferase MtmB | 0 | Direct |
| SET domain | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
| Thymidylate synthase/dCMP hydroxymethylase | 0 | Direct |
| Methionine synthase domain | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Thymidylate synthase-complementing protein Thy1 | 0 | Direct |
| RuBisCo LSMT C-terminal, substrate-binding domain | 0 | Direct |
| Aspartate/ornithine carbamoyltransferase | 0 | Direct |
| SSo0622-like | 0 | Direct |
| S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
| CbiD-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| FMT C-terminal domain-like | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| Cobalamin (vitamin B12)-binding domain | 0.00000000166 | Direct |
| RNA-binding domain, RBD | 0.00000000259 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.00000001686 | Direct |
| PLP-dependent transferases | 0.00000001963 | Direct |
| Dihydropteroate synthetase-like | 0.000001552 | Direct |
| HMG-box | 0.000002915 | Direct |
| Galactose oxidase, central domain | 0.00002182 | Direct |
| Chromo domain-like | 0.0001503 | Direct |
| Dihydrofolate reductase-like | 0.0003587 | Direct |
| FAD-linked reductases, C-terminal domain | 0.0007729 | Direct |
| Kelch motif | 0.001701 | Inherited |
| Nucleotide-binding domain | 0.003629 | Inherited |
| CYTH-like phosphatases | 0.007729 | Inherited |
| Radical SAM enzymes | 0.009096 | Inherited |
| Tudor/PWWP/MBT | 0.06436 | Inherited |
| "Winged helix" DNA-binding domain | 0.3086 | Inherited |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3413 | Inherited |
| Homeodomain-like | 0.5295 | Inherited |
| Trypsin-like serine proteases | 0.6177 | Inherited |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0.9024 | Inherited |
| FYVE/PHD zinc finger | 0.9414 | Inherited |
| lambda repressor-like DNA-binding domains | 0.9837 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| E set domains | 1 | Inherited |
| Rudiment single hybrid motif | 1 | Inherited |
| TPR-like | 1 | Inherited |
| Carbamoyl phosphate synthetase, large subunit connection domain | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| PUA domain-like | 1 | Inherited |
| SH3-domain | 1 | Inherited |
| Pentein | 1 | Inherited |
| Clavaminate synthase-like | 1 | Inherited |
| PurM C-terminal domain-like | 1 | Inherited |
| THUMP domain-like | 1 | Inherited |
| PurM N-terminal domain-like | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| DNA/RNA polymerases | 1 | Inherited |
| WW domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55315,75217
55315 - L30e-like
75217 - alpha/beta knot | 0 | DIRECT |
82282,51717
82282 - Homocysteine S-methyltransferase
51717 - Dihydropteroate synthetase-like | 0 | DIRECT |
53155,46767
53155 - Methylated DNA-protein cysteine methyltransferase domain
46767 - Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | DIRECT |
82199,81822
82199 - SET domain
81822 - RuBisCo LSMT C-terminal, substrate-binding domain | 0 | DIRECT |
57884,46689
57884 - Ada DNA repair protein, N-terminal domain (N-Ada 10)
46689 - Homeodomain-like | 0 | DIRECT |
51726,51726
51726 - UROD/MetE-like
51726 - UROD/MetE-like | 0 | DIRECT |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | DIRECT |
53790,53335
53790 - Tetrapyrrole methylase
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
88697,75217
88697 - PUA domain-like
75217 - alpha/beta knot | 0 | DIRECT |
53335,53335
53335 - S-adenosyl-L-methionine-dependent methyltransferases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
52335,51556
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | DIRECT |
54160,82199
54160 - Chromo domain-like
82199 - SET domain | 0 | DIRECT |
51197,53335
51197 - Clavaminate synthase-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 0 | DIRECT |
54160,53335
54160 - Chromo domain-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
88697,53335
88697 - PUA domain-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
50044,53335
50044 - SH3-domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
48013,53335
48013 - NusB-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | DIRECT |
75217,54593
75217 - alpha/beta knot
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
53335,53383
53335 - S-adenosyl-L-methionine-dependent methyltransferases
53383 - PLP-dependent transferases | 0 | DIRECT |
75217,109604
75217 - alpha/beta knot
109604 - HD-domain/PDEase-like | 0 | DIRECT |
143437,53335
143437 - THUMP domain-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
53335,50249
53335 - S-adenosyl-L-methionine-dependent methyltransferases
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
56042,53328
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | DIRECT |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | DIRECT |
47413,53335
47413 - lambda repressor-like DNA-binding domains
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
51717,47644
51717 - Dihydropteroate synthetase-like
47644 - Methionine synthase domain | 0 | DIRECT |
52335,53927
52335 - Methylglyoxal synthase-like
53927 - Cytidine deaminase-like | 0 | DIRECT |
48452,53335
48452 - TPR-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
50249,53335
50249 - Nucleic acid-binding proteins
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
75217,75217
75217 - alpha/beta knot
75217 - alpha/beta knot | 0 | DIRECT |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
47757,53335
47757 - Chemotaxis receptor methyltransferase CheR, N-terminal domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
47644,52242
47644 - Methionine synthase domain
52242 - Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
46785,53335
46785 - "Winged helix" DNA-binding domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
52242,56507
52242 - Cobalamin (vitamin B12)-binding domain
56507 - Methionine synthase activation domain-like | 0 | DIRECT |
53335,50965
53335 - S-adenosyl-L-methionine-dependent methyltransferases
50965 - Galactose oxidase, central domain | 0 | DIRECT |
50965,51197
50965 - Galactose oxidase, central domain
51197 - Clavaminate synthase-like | 0 | DIRECT |
53597,55831
53597 - Dihydrofolate reductase-like
55831 - Thymidylate synthase/dCMP hydroxymethylase | 0 | DIRECT |
54928,51197
54928 - RNA-binding domain, RBD
51197 - Clavaminate synthase-like | 0 | DIRECT |
117281,51197
117281 - Kelch motif
51197 - Clavaminate synthase-like | 0 | DIRECT |
53335,51905
53335 - S-adenosyl-L-methionine-dependent methyltransferases
51905 - FAD/NAD(P)-binding domain | 0 | DIRECT |
53335,81799
53335 - S-adenosyl-L-methionine-dependent methyltransferases
81799 - Putative methyltransferase TM0872, insert domain | 0 | DIRECT |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000002207 | DIRECT |
52317,52440
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0.0000000001557 | DIRECT |
51246,55326
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0.0000001637 | DIRECT |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0.000002409 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.00002182 | DIRECT |
53474,53335
53474 - alpha/beta-Hydrolases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.00007504 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.001195 | INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase || Methyltransferases |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.1168 | INHERITED FROM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase |
52021,52317
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like | 0.9024 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
56059,52335
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0.9922 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 1 | INHERITED FROM: Aspartate carbamoyltransferase |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase || Methyltransferase cap1 |
56042,55326
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
48108,52440
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Phosphoribosylglycinamide formyltransferase |
53383,53383
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 1 | INHERITED FROM: Methionine S-methyltransferase |
56059,48108
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55315,75217
55315 - L30e-like
75217 - alpha/beta knot | 0 | Direct |
82282,51717
82282 - Homocysteine S-methyltransferase
51717 - Dihydropteroate synthetase-like | 0 | Direct |
53155,46767
53155 - Methylated DNA-protein cysteine methyltransferase domain
46767 - Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0 | Direct |
82199,81822
82199 - SET domain
81822 - RuBisCo LSMT C-terminal, substrate-binding domain | 0 | Direct |
57884,46689
57884 - Ada DNA repair protein, N-terminal domain (N-Ada 10)
46689 - Homeodomain-like | 0 | Direct |
51726,51726
51726 - UROD/MetE-like
51726 - UROD/MetE-like | 0 | Direct |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | Direct |
53790,53335
53790 - Tetrapyrrole methylase
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
88697,75217
88697 - PUA domain-like
75217 - alpha/beta knot | 0 | Direct |
53335,53335
53335 - S-adenosyl-L-methionine-dependent methyltransferases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
52335,51556
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | Direct |
55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | Direct |
54160,82199
54160 - Chromo domain-like
82199 - SET domain | 0 | Direct |
51197,53335
51197 - Clavaminate synthase-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 0 | Direct |
54160,53335
54160 - Chromo domain-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
88697,53335
88697 - PUA domain-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | Direct |
50044,53335
50044 - SH3-domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
48013,53335
48013 - NusB-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0 | Direct |
75217,54593
75217 - alpha/beta knot
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
53335,53383
53335 - S-adenosyl-L-methionine-dependent methyltransferases
53383 - PLP-dependent transferases | 0 | Direct |
75217,109604
75217 - alpha/beta knot
109604 - HD-domain/PDEase-like | 0 | Direct |
143437,53335
143437 - THUMP domain-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
53335,50249
53335 - S-adenosyl-L-methionine-dependent methyltransferases
50249 - Nucleic acid-binding proteins | 0 | Direct |
56042,53328
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | Direct |
50486,51735
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | Direct |
47413,53335
47413 - lambda repressor-like DNA-binding domains
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
51717,47644
51717 - Dihydropteroate synthetase-like
47644 - Methionine synthase domain | 0 | Direct |
52335,53927
52335 - Methylglyoxal synthase-like
53927 - Cytidine deaminase-like | 0 | Direct |
48452,53335
48452 - TPR-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
50249,53335
50249 - Nucleic acid-binding proteins
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | Direct |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
75217,75217
75217 - alpha/beta knot
75217 - alpha/beta knot | 0 | Direct |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
47757,53335
47757 - Chemotaxis receptor methyltransferase CheR, N-terminal domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
47644,52242
47644 - Methionine synthase domain
52242 - Cobalamin (vitamin B12)-binding domain | 0 | Direct |
46785,53335
46785 - "Winged helix" DNA-binding domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
52242,56507
52242 - Cobalamin (vitamin B12)-binding domain
56507 - Methionine synthase activation domain-like | 0 | Direct |
53335,50965
53335 - S-adenosyl-L-methionine-dependent methyltransferases
50965 - Galactose oxidase, central domain | 0 | Direct |
50965,51197
50965 - Galactose oxidase, central domain
51197 - Clavaminate synthase-like | 0 | Direct |
53597,55831
53597 - Dihydrofolate reductase-like
55831 - Thymidylate synthase/dCMP hydroxymethylase | 0 | Direct |
54928,51197
54928 - RNA-binding domain, RBD
51197 - Clavaminate synthase-like | 0 | Direct |
117281,51197
117281 - Kelch motif
51197 - Clavaminate synthase-like | 0 | Direct |
53335,51905
53335 - S-adenosyl-L-methionine-dependent methyltransferases
51905 - FAD/NAD(P)-binding domain | 0 | Direct |
53335,81799
53335 - S-adenosyl-L-methionine-dependent methyltransferases
81799 - Putative methyltransferase TM0872, insert domain | 0 | Direct |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000002207 | Direct |
52317,52440
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0.0000000001557 | Direct |
51246,55326
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0.0000001637 | Direct |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0.000002409 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.00002182 | Direct |
53474,53335
53474 - alpha/beta-Hydrolases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.00007504 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.001195 | Inherited |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.1168 | Inherited |
52021,52317
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like | 0.9024 | Inherited |
56059,52335
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0.9922 | Inherited |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 1 | Inherited |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 1 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
56042,55326
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 1 | Inherited |
48108,52440
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 1 | Inherited |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | Inherited |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
53383,53383
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 1 | Inherited |
56059,48108
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55326,56042,53328
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | DIRECT |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53335,50965,51197
53335 - S-adenosyl-L-methionine-dependent methyltransferases
50965 - Galactose oxidase, central domain
51197 - Clavaminate synthase-like | 0 | DIRECT |
54928,51197,53335
54928 - RNA-binding domain, RBD
51197 - Clavaminate synthase-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
82282,51717,47644
82282 - Homocysteine S-methyltransferase
51717 - Dihydropteroate synthetase-like
47644 - Methionine synthase domain | 0 | DIRECT |
52335,51556,51338
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
56059,52335,51556
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
51717,47644,52242
51717 - Dihydropteroate synthetase-like
47644 - Methionine synthase domain
52242 - Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
57903,57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47644,52242,56507
47644 - Methionine synthase domain
52242 - Cobalamin (vitamin B12)-binding domain
56507 - Methionine synthase activation domain-like | 0 | DIRECT |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53335,51905,54373
53335 - S-adenosyl-L-methionine-dependent methyltransferases
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
53335,53383,53383
53335 - S-adenosyl-L-methionine-dependent methyltransferases
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 0 | DIRECT |
55116,55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | DIRECT |
52317,52440,56059
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0.0000000001557 | DIRECT |
52021,52317,52440
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0.0000000001557 | DIRECT |
56059,51246,55326
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0.0000001637 | DIRECT |
51246,55326,56042
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0.0000001637 | DIRECT |
52440,56059,52335
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0.9897 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
48108,52440,56059
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
55326,56042,55326
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
52440,56059,48108
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
56042,55326,56042
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylglycinamide formyltransferase |
56059,48108,52440
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 1 | INHERITED FROM: Aspartate carbamoyltransferase || Carboxy- and carbamoyltransferases |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55326,56042,53328
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | Direct |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53335,50965,51197
53335 - S-adenosyl-L-methionine-dependent methyltransferases
50965 - Galactose oxidase, central domain
51197 - Clavaminate synthase-like | 0 | Direct |
54928,51197,53335
54928 - RNA-binding domain, RBD
51197 - Clavaminate synthase-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
82282,51717,47644
82282 - Homocysteine S-methyltransferase
51717 - Dihydropteroate synthetase-like
47644 - Methionine synthase domain | 0 | Direct |
52335,51556,51338
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
56059,52335,51556
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | Direct |
51717,47644,52242
51717 - Dihydropteroate synthetase-like
47644 - Methionine synthase domain
52242 - Cobalamin (vitamin B12)-binding domain | 0 | Direct |
57903,57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
47644,52242,56507
47644 - Methionine synthase domain
52242 - Cobalamin (vitamin B12)-binding domain
56507 - Methionine synthase activation domain-like | 0 | Direct |
53328,50486,51735
53328 - Formyltransferase
50486 - FMT C-terminal domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53335,51905,54373
53335 - S-adenosyl-L-methionine-dependent methyltransferases
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
53335,53383,53383
53335 - S-adenosyl-L-methionine-dependent methyltransferases
53383 - PLP-dependent transferases
53383 - PLP-dependent transferases | 0 | Direct |
55116,55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | Direct |
52317,52440,56059
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0.0000000001557 | Direct |
52021,52317,52440
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0.0000000001557 | Direct |
56059,51246,55326
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0.0000001637 | Direct |
51246,55326,56042
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0.0000001637 | Direct |
52440,56059,52335
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0.9897 | Inherited |
48108,52440,56059
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
55326,56042,55326
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 1 | Inherited |
52440,56059,48108
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 1 | Inherited |
56042,55326,56042
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 1 | Inherited |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | Inherited |
56059,48108,52440
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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