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Enzyme Commission (EC): Aminoacyltransferases
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Informative)
Highlighted in gray are those with FDR_all>0.001
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,52540 57850 - RING/U-box 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52025,57850 52025 - PA domain 57850 - RING/U-box | 0 | DIRECT |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | DIRECT |
57850,57667 57850 - RING/U-box 57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
49599,50156 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | DIRECT |
56112,57850 56112 - Protein kinase-like (PK-like) 57850 - RING/U-box | 0 | DIRECT |
161245,57850 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | DIRECT |
81296,54001 81296 - E set domains 54001 - Cysteine proteinases | 0 | DIRECT |
68906,57850 68906 - SAP domain 57850 - RING/U-box | 0 | DIRECT |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0 | DIRECT |
53300,57850 53300 - vWA-like 57850 - RING/U-box | 0 | DIRECT |
117839,117839 117839 - WWE domain 117839 - WWE domain | 0 | DIRECT |
54001,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
57850,101898 57850 - RING/U-box 101898 - NHL repeat | 0 | DIRECT |
57850,50978 57850 - RING/U-box 50978 - WD40 repeat-like | 0 | DIRECT |
57953,49599 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | DIRECT |
90209,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | DIRECT |
55550,57850 55550 - SH2 domain 57850 - RING/U-box | 0 | DIRECT |
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | DIRECT |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0 | DIRECT |
57850,117839 57850 - RING/U-box 117839 - WWE domain | 0 | DIRECT |
54495,46934 54495 - UBC-like 46934 - UBA-like | 0 | DIRECT |
49879,57850 49879 - SMAD/FHA domain 57850 - RING/U-box | 0 | DIRECT |
57903,57850 57903 - FYVE/PHD zinc finger 57850 - RING/U-box | 0 | DIRECT |
63570,56204 63570 - PABC (PABP) domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
48452,57850 48452 - TPR-like 57850 - RING/U-box | 0 | DIRECT |
49599,57953 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF | 0 | DIRECT |
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like | 0 | DIRECT |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54236,90209 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
81296,101898 81296 - E set domains 101898 - NHL repeat | 0 | DIRECT |
48403,57850 48403 - Ankyrin repeat 57850 - RING/U-box | 0 | DIRECT |
49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
57850,48371 57850 - RING/U-box 48371 - ARM repeat | 0 | DIRECT |
48371,117839 48371 - ARM repeat 117839 - WWE domain | 0 | DIRECT |
49785,50985 49785 - Galactose-binding domain-like 50985 - RCC1/BLIP-II | 0 | DIRECT |
49785,159034 49785 - Galactose-binding domain-like 159034 - Mib/herc2 domain-like | 0 | DIRECT |
57850,159034 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | DIRECT |
49309,49309 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
54495,57850 54495 - UBC-like 57850 - RING/U-box | 0 | DIRECT |
161219,161245 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack | 0 | DIRECT |
159034,57850 159034 - Mib/herc2 domain-like 57850 - RING/U-box | 0 | DIRECT |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0 | DIRECT |
46589,55729 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
48403,52113 48403 - Ankyrin repeat 52113 - BRCT domain | 0 | DIRECT |
55729,46589 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm | 0 | DIRECT |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
90229,57850 90229 - CCCH zinc finger 57850 - RING/U-box | 0 | DIRECT |
47473,55550 47473 - EF-hand 55550 - SH2 domain | 0 | DIRECT |
47592,90209 47592 - SWIB/MDM2 domain 90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
49599,160088 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | DIRECT |
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand | 0 | DIRECT |
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
49562,51045 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 51045 - WW domain | 0 | DIRECT |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0.0000000000004428 | DIRECT |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.000000000004573 | DIRECT |
48371,48403 48371 - ARM repeat 48403 - Ankyrin repeat | 0.0000000003655 | DIRECT |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.00000004781 | DIRECT |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0.0000005931 | DIRECT |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.000002282 | DIRECT |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.0000173 | DIRECT |
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases | 0.0968 | INHERITED FROM: Lysyltransferase |
55729,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 55729 - Acyl-CoA N-acyltransferases (Nat) | 0.4251 | INHERITED FROM: Lipid II:glycine glycyltransferase || glycyltransferase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,52540 57850 - RING/U-box 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52025,57850 52025 - PA domain 57850 - RING/U-box | 0 | Direct |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | Direct |
57850,57667 57850 - RING/U-box 57667 - beta-beta-alpha zinc fingers | 0 | Direct |
49599,50156 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | Direct |
56112,57850 56112 - Protein kinase-like (PK-like) 57850 - RING/U-box | 0 | Direct |
161245,57850 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | Direct |
81296,54001 81296 - E set domains 54001 - Cysteine proteinases | 0 | Direct |
68906,57850 68906 - SAP domain 57850 - RING/U-box | 0 | Direct |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0 | Direct |
53300,57850 53300 - vWA-like 57850 - RING/U-box | 0 | Direct |
117839,117839 117839 - WWE domain 117839 - WWE domain | 0 | Direct |
54001,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
57850,101898 57850 - RING/U-box 101898 - NHL repeat | 0 | Direct |
57850,50978 57850 - RING/U-box 50978 - WD40 repeat-like | 0 | Direct |
57953,49599 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | Direct |
90209,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | Direct |
55550,57850 55550 - SH2 domain 57850 - RING/U-box | 0 | Direct |
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | Direct |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0 | Direct |
57850,117839 57850 - RING/U-box 117839 - WWE domain | 0 | Direct |
54495,46934 54495 - UBC-like 46934 - UBA-like | 0 | Direct |
49879,57850 49879 - SMAD/FHA domain 57850 - RING/U-box | 0 | Direct |
57903,57850 57903 - FYVE/PHD zinc finger 57850 - RING/U-box | 0 | Direct |
63570,56204 63570 - PABC (PABP) domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
48452,57850 48452 - TPR-like 57850 - RING/U-box | 0 | Direct |
49599,57953 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF | 0 | Direct |
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like | 0 | Direct |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54236,90209 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like | 0 | Direct |
81296,101898 81296 - E set domains 101898 - NHL repeat | 0 | Direct |
48403,57850 48403 - Ankyrin repeat 57850 - RING/U-box | 0 | Direct |
49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
57850,48371 57850 - RING/U-box 48371 - ARM repeat | 0 | Direct |
48371,117839 48371 - ARM repeat 117839 - WWE domain | 0 | Direct |
49785,50985 49785 - Galactose-binding domain-like 50985 - RCC1/BLIP-II | 0 | Direct |
49785,159034 49785 - Galactose-binding domain-like 159034 - Mib/herc2 domain-like | 0 | Direct |
57850,159034 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | Direct |
49309,49309 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
54495,57850 54495 - UBC-like 57850 - RING/U-box | 0 | Direct |
161219,161245 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack | 0 | Direct |
159034,57850 159034 - Mib/herc2 domain-like 57850 - RING/U-box | 0 | Direct |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0 | Direct |
46589,55729 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
48403,52113 48403 - Ankyrin repeat 52113 - BRCT domain | 0 | Direct |
55729,46589 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm | 0 | Direct |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
90229,57850 90229 - CCCH zinc finger 57850 - RING/U-box | 0 | Direct |
47473,55550 47473 - EF-hand 55550 - SH2 domain | 0 | Direct |
47592,90209 47592 - SWIB/MDM2 domain 90209 - Ran binding protein zinc finger-like | 0 | Direct |
49599,160088 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | Direct |
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand | 0 | Direct |
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
49562,51045 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 51045 - WW domain | 0 | Direct |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0.0000000000004428 | Direct |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.000000000004573 | Direct |
48371,48403 48371 - ARM repeat 48403 - Ankyrin repeat | 0.0000000003655 | Direct |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.00000004781 | Direct |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0.0000005931 | Direct |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.000002282 | Direct |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.0000173 | Direct |
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases | 0.0968 | Inherited |
55729,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 55729 - Acyl-CoA N-acyltransferases (Nat) | 0.4251 | Inherited |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81296,54001,49309 81296 - E set domains 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
55729,46589,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
161219,161245,57850 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | DIRECT |
49599,49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
54001,49309,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
57850,49599,160088 57850 - RING/U-box 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | DIRECT |
49599,57953,49599 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | DIRECT |
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
51045,51045,51045 51045 - WW domain 51045 - WW domain 51045 - WW domain | 0 | DIRECT |
48403,52113,52113 48403 - Ankyrin repeat 52113 - BRCT domain 52113 - BRCT domain | 0 | DIRECT |
90209,57850,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
57850,49599,50156 57850 - RING/U-box 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | DIRECT |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain | 0 | DIRECT |
54236,90209,57850 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | DIRECT |
57850,48371,48371 57850 - RING/U-box 48371 - ARM repeat 48371 - ARM repeat | 0 | DIRECT |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
159034,57850,159034 159034 - Mib/herc2 domain-like 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | DIRECT |
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box | 0 | DIRECT |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0.0000005931 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81296,54001,49309 81296 - E set domains 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
55729,46589,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
161219,161245,57850 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | Direct |
49599,49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
54001,49309,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
57850,49599,160088 57850 - RING/U-box 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | Direct |
49599,57953,49599 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | Direct |
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
51045,51045,51045 51045 - WW domain 51045 - WW domain 51045 - WW domain | 0 | Direct |
48403,52113,52113 48403 - Ankyrin repeat 52113 - BRCT domain 52113 - BRCT domain | 0 | Direct |
90209,57850,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
57850,49599,50156 57850 - RING/U-box 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | Direct |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain | 0 | Direct |
54236,90209,57850 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | Direct |
57850,48371,48371 57850 - RING/U-box 48371 - ARM repeat 48371 - ARM repeat | 0 | Direct |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0 | Direct |
159034,57850,159034 159034 - Mib/herc2 domain-like 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | Direct |
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box | 0 | Direct |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0.0000005931 | Direct |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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