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Enzyme Commission (EC): Glycosyltransferases
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Glycogenin | 0 | DIRECT |
Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
Glycosyltransferase family 36 C-terminal domain | 0 | DIRECT |
N-acetylglucosaminyltransferase I | 0 | DIRECT |
Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) | 0 | DIRECT |
Glycosyl transferases group 1 | 0 | DIRECT |
Thi4-like | 0 | DIRECT |
ATP phosphoribosyltransferase (ATP-PRTase, HisG), regulatory C-terminal domain | 0 | DIRECT |
Glycosyltransferase family 36 N-terminal domain | 0 | DIRECT |
Glycosyl hydrolases family 16 | 0 | DIRECT |
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain | 0 | DIRECT |
MIR domain | 0 | DIRECT |
PBP transglycosylase domain-like | 0 | DIRECT |
E-set domains of sugar-utilizing enzymes | 0 | DIRECT |
UDPGT-like | 0 | DIRECT |
Trehalose-6-phosphate synthase, OtsA | 0 | DIRECT |
Amylase, catalytic domain | 0 | DIRECT |
FucT-like | 0 | DIRECT |
Purine and uridine phosphorylases | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Peptidoglycan biosynthesis glycosyltransferase MurG | 0 | DIRECT |
QueA-like | 0 | DIRECT |
Archaeosine tRNA-guanine transglycosylase, C2 domain | 0 | DIRECT |
NadC N-terminal domain-like | 0 | DIRECT |
Phosphate binding protein-like | 0 | DIRECT |
ADP-ribosylating toxins | 0 | DIRECT |
Exostosin | 0 | DIRECT |
Ricin B-like | 0 | DIRECT |
Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
AmyC C-terminal domain-like | 0 | DIRECT |
1,3-glucuronyltransferase | 0 | DIRECT |
N-deoxyribosyltransferase | 0 | DIRECT |
AmyC N-terminal domain-like | 0 | DIRECT |
alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
alpha-1,3-galactosyltransferase-like | 0 | DIRECT |
Levansucrase | 0 | DIRECT |
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
VPA0057-like | 0 | DIRECT |
tRNA-guanine transglycosylase | 0 | DIRECT |
Ecto-ART | 0 | DIRECT |
Gtf glycosyltransferase | 0 | DIRECT |
Galactosyltransferase LgtC | 0 | DIRECT |
NadC C-terminal domain-like | 0 | DIRECT |
Pyrimidine nucleoside phosphorylase C-terminal domain | 0 | DIRECT |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
Oligosaccharide phosphorylase | 0 | DIRECT |
TM1225-like predicted glycosylases | 0 | DIRECT |
beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
WGR domain | 0 | DIRECT |
Starch-binding domain | 0.000000000000001101 | DIRECT |
PARP-type zinc finger | 0.000000000000001826 | DIRECT |
Tetratricopeptide repeat (TPR) | 0.000000000000004356 | DIRECT |
Spore coat polysaccharide biosynthesis protein SpsA | 0.000000000005792 | DIRECT |
ADP ribosyl cyclase-like | 0.000000000348 | DIRECT |
Cell wall binding repeat | 0.0000002744 | DIRECT |
PUA domain | 0.00000486 | DIRECT |
Filamin repeat (rod domain) | 0.003883 | INHERITED FROM: Protein xylosyltransferase || Pentosyltransferases |
Trehalose-phosphatase | 0.006038 | INHERITED FROM: Hexosyltransferases || Alpha,alpha-trehalose-phosphate synthase (UDP-forming) |
Class II glutamine amidotransferases | 0.006438 | INHERITED FROM: Amidophosphoribosyltransferase || Pentosyltransferases |
SAP domain | 0.1086 | INHERITED FROM: NAD(+) ADP-ribosyltransferase |
Pleckstrin-homology domain (PH domain) | 0.239 | INHERITED FROM: Hexosyltransferases || Sterol 3-beta-glucosyltransferase |
Fibronectin type III | 0.8261 | INHERITED FROM: Protein O-mannose beta-1,4-N-acetylglucosaminyltransferase || Hexosyltransferases |
PP-loop ATPase | 1 | INHERITED FROM: Hypoxanthine phosphoribosyltransferase |
GHMP Kinase, N-terminal domain | 1 | INHERITED FROM: Beta-ribofuranosylphenol 5'-phosphate synthase |
DNA ligase | 1 | INHERITED FROM: NAD(+) ADP-ribosyltransferase |
Ankyrin repeat | 1 | INHERITED FROM: NAD(+) ADP-ribosyltransferase |
Phosphoribulokinase/pantothenate kinase | 1 | INHERITED FROM: Uracil phosphoribosyltransferase |
SH3-domain | 1 | INHERITED FROM: Hexosyltransferases || Glycoprotein 6-alpha-L-fucosyltransferase |
Decarboxylase | 1 | INHERITED FROM: Orotate phosphoribosyltransferase |
RING finger domain, C3HC4 | 1 | INHERITED FROM: Hexosyltransferases || Cellulose synthase (UDP-forming) |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Glycogenin | 0 | Direct |
Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
Glycosyltransferase family 36 C-terminal domain | 0 | Direct |
N-acetylglucosaminyltransferase I | 0 | Direct |
Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) | 0 | Direct |
Glycosyl transferases group 1 | 0 | Direct |
Thi4-like | 0 | Direct |
ATP phosphoribosyltransferase (ATP-PRTase, HisG), regulatory C-terminal domain | 0 | Direct |
Glycosyltransferase family 36 N-terminal domain | 0 | Direct |
Glycosyl hydrolases family 16 | 0 | Direct |
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain | 0 | Direct |
MIR domain | 0 | Direct |
PBP transglycosylase domain-like | 0 | Direct |
E-set domains of sugar-utilizing enzymes | 0 | Direct |
UDPGT-like | 0 | Direct |
Trehalose-6-phosphate synthase, OtsA | 0 | Direct |
Amylase, catalytic domain | 0 | Direct |
FucT-like | 0 | Direct |
Purine and uridine phosphorylases | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Peptidoglycan biosynthesis glycosyltransferase MurG | 0 | Direct |
QueA-like | 0 | Direct |
Archaeosine tRNA-guanine transglycosylase, C2 domain | 0 | Direct |
NadC N-terminal domain-like | 0 | Direct |
Phosphate binding protein-like | 0 | Direct |
ADP-ribosylating toxins | 0 | Direct |
Exostosin | 0 | Direct |
Ricin B-like | 0 | Direct |
Phosphoribosyltransferases (PRTases) | 0 | Direct |
beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
AmyC C-terminal domain-like | 0 | Direct |
1,3-glucuronyltransferase | 0 | Direct |
N-deoxyribosyltransferase | 0 | Direct |
AmyC N-terminal domain-like | 0 | Direct |
alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
alpha-1,3-galactosyltransferase-like | 0 | Direct |
Levansucrase | 0 | Direct |
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
VPA0057-like | 0 | Direct |
tRNA-guanine transglycosylase | 0 | Direct |
Ecto-ART | 0 | Direct |
Gtf glycosyltransferase | 0 | Direct |
Galactosyltransferase LgtC | 0 | Direct |
NadC C-terminal domain-like | 0 | Direct |
Pyrimidine nucleoside phosphorylase C-terminal domain | 0 | Direct |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
Oligosaccharide phosphorylase | 0 | Direct |
TM1225-like predicted glycosylases | 0 | Direct |
beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
WGR domain | 0 | Direct |
Starch-binding domain | 0.000000000000001101 | Direct |
PARP-type zinc finger | 0.000000000000001826 | Direct |
Tetratricopeptide repeat (TPR) | 0.000000000000004356 | Direct |
Spore coat polysaccharide biosynthesis protein SpsA | 0.000000000005792 | Direct |
ADP ribosyl cyclase-like | 0.000000000348 | Direct |
Cell wall binding repeat | 0.0000002744 | Direct |
PUA domain | 0.00000486 | Direct |
Filamin repeat (rod domain) | 0.003883 | Inherited |
Trehalose-phosphatase | 0.006038 | Inherited |
Class II glutamine amidotransferases | 0.006438 | Inherited |
SAP domain | 0.1086 | Inherited |
Pleckstrin-homology domain (PH domain) | 0.239 | Inherited |
Fibronectin type III | 0.8261 | Inherited |
PP-loop ATPase | 1 | Inherited |
GHMP Kinase, N-terminal domain | 1 | Inherited |
DNA ligase | 1 | Inherited |
Ankyrin repeat | 1 | Inherited |
Phosphoribulokinase/pantothenate kinase | 1 | Inherited |
SH3-domain | 1 | Inherited |
Decarboxylase | 1 | Inherited |
RING finger domain, C3HC4 | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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Supra-domain (including individual superfamily)
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Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56235,53271 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases) 53271 - PRTase-like | 0 | DIRECT |
81296,51445 81296 - E set domains 51445 - (Trans)glycosidases | 0 | DIRECT |
52540,47648 52540 - P-loop containing nucleoside triphosphate hydrolases 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
81296,81296 81296 - E set domains 81296 - E set domains | 0 | DIRECT |
47648,52418 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
53850,54913 53850 - Periplasmic binding protein-like II 54913 - GlnB-like | 0 | DIRECT |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0 | DIRECT |
52418,54680 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 54680 - Pyrimidine nucleoside phosphorylase C-terminal domain | 0 | DIRECT |
52113,142921 52113 - BRCT domain 142921 - WGR domain-like | 0 | DIRECT |
53448,50370 53448 - Nucleotide-diphospho-sugar transferases 50370 - Ricin B-like lectins | 0 | DIRECT |
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 0 | DIRECT |
53756,56784 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 56784 - HAD-like | 0 | DIRECT |
53756,53756 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53756 - UDP-Glycosyltransferase/glycogen phosphorylase | 0 | DIRECT |
74650,48208 74650 - Galactose mutarotase-like 48208 - Six-hairpin glycosidases | 0 | DIRECT |
52317,47648 52317 - Class I glutamine amidotransferase-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
53955,56601 53955 - Lysozyme-like 56601 - beta-lactamase/transpeptidase-like | 0 | DIRECT |
88802,88697 88802 - Pre-PUA domain 88697 - PUA domain-like | 0 | DIRECT |
47769,56399 47769 - SAM/Pointed domain 56399 - ADP-ribosylation | 0 | DIRECT |
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
51011,81296 51011 - Glycosyl hydrolase domain 81296 - E set domains | 0 | DIRECT |
69360,51445 69360 - Cell wall binding repeat 51445 - (Trans)glycosidases | 0 | DIRECT |
50692,47648 50692 - ADC-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
56037,53271 56037 - PheT/TilS domain 53271 - PRTase-like | 0 | DIRECT |
53271,51366 53271 - PRTase-like 51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
51713,88802 51713 - tRNA-guanine transglycosylase 88802 - Pre-PUA domain | 0 | DIRECT |
81296,49452 81296 - E set domains 49452 - Starch-binding domain-like | 0 | DIRECT |
51445,69360 51445 - (Trans)glycosidases 69360 - Cell wall binding repeat | 0.000000001724 | DIRECT |
69360,69360 69360 - Cell wall binding repeat 69360 - Cell wall binding repeat | 0.000000001724 | DIRECT |
54675,51690 54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like | 0.00000001209 | DIRECT |
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat | 0.0000002058 | DIRECT |
51690,-9 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like -9 - PDB | 0.000003281 | DIRECT |
53448,53448 53448 - Nucleotide-diphospho-sugar transferases 53448 - Nucleotide-diphospho-sugar transferases | 0.0001585 | DIRECT |
52540,53271 52540 - P-loop containing nucleoside triphosphate hydrolases 53271 - PRTase-like | 0.000255 | DIRECT |
48403,47769 48403 - Ankyrin repeat 47769 - SAM/Pointed domain | 0.0002913 | DIRECT |
-9,-9 -9 - PDB -9 - PDB | 0.004074 | INHERITED FROM: Nicotinamide phosphoribosyltransferase || Pentosyltransferases |
88713,88688 88713 - Glycoside hydrolase/deacetylase 88688 - Families 57/38 glycoside transferase middle domain | 0.02161 | INHERITED FROM: Hexosyltransferases |
82829,56037 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain | 0.6698 | INHERITED FROM: Hypoxanthine phosphoribosyltransferase |
52402,82829 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like | 0.9279 | INHERITED FROM: Hypoxanthine phosphoribosyltransferase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56235,53271 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases) 53271 - PRTase-like | 0 | Direct |
81296,51445 81296 - E set domains 51445 - (Trans)glycosidases | 0 | Direct |
52540,47648 52540 - P-loop containing nucleoside triphosphate hydrolases 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
81296,81296 81296 - E set domains 81296 - E set domains | 0 | Direct |
47648,52418 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
53850,54913 53850 - Periplasmic binding protein-like II 54913 - GlnB-like | 0 | Direct |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0 | Direct |
52418,54680 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 54680 - Pyrimidine nucleoside phosphorylase C-terminal domain | 0 | Direct |
52113,142921 52113 - BRCT domain 142921 - WGR domain-like | 0 | Direct |
53448,50370 53448 - Nucleotide-diphospho-sugar transferases 50370 - Ricin B-like lectins | 0 | Direct |
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 0 | Direct |
53756,56784 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 56784 - HAD-like | 0 | Direct |
53756,53756 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53756 - UDP-Glycosyltransferase/glycogen phosphorylase | 0 | Direct |
74650,48208 74650 - Galactose mutarotase-like 48208 - Six-hairpin glycosidases | 0 | Direct |
52317,47648 52317 - Class I glutamine amidotransferase-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
53955,56601 53955 - Lysozyme-like 56601 - beta-lactamase/transpeptidase-like | 0 | Direct |
88802,88697 88802 - Pre-PUA domain 88697 - PUA domain-like | 0 | Direct |
47769,56399 47769 - SAM/Pointed domain 56399 - ADP-ribosylation | 0 | Direct |
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
51011,81296 51011 - Glycosyl hydrolase domain 81296 - E set domains | 0 | Direct |
69360,51445 69360 - Cell wall binding repeat 51445 - (Trans)glycosidases | 0 | Direct |
50692,47648 50692 - ADC-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
56037,53271 56037 - PheT/TilS domain 53271 - PRTase-like | 0 | Direct |
53271,51366 53271 - PRTase-like 51366 - Ribulose-phoshate binding barrel | 0 | Direct |
51713,88802 51713 - tRNA-guanine transglycosylase 88802 - Pre-PUA domain | 0 | Direct |
81296,49452 81296 - E set domains 49452 - Starch-binding domain-like | 0 | Direct |
51445,69360 51445 - (Trans)glycosidases 69360 - Cell wall binding repeat | 0.000000001724 | Direct |
69360,69360 69360 - Cell wall binding repeat 69360 - Cell wall binding repeat | 0.000000001724 | Direct |
54675,51690 54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like | 0.00000001209 | Direct |
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat | 0.0000002058 | Direct |
51690,-9 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like -9 - PDB | 0.000003281 | Direct |
53448,53448 53448 - Nucleotide-diphospho-sugar transferases 53448 - Nucleotide-diphospho-sugar transferases | 0.0001585 | Direct |
52540,53271 52540 - P-loop containing nucleoside triphosphate hydrolases 53271 - PRTase-like | 0.000255 | Direct |
48403,47769 48403 - Ankyrin repeat 47769 - SAM/Pointed domain | 0.0002913 | Direct |
-9,-9 -9 - PDB -9 - PDB | 0.004074 | Inherited |
88713,88688 88713 - Glycoside hydrolase/deacetylase 88688 - Families 57/38 glycoside transferase middle domain | 0.02161 | Inherited |
82829,56037 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain | 0.6698 | Inherited |
52402,82829 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like | 0.9279 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51011,81296,49452 51011 - Glycosyl hydrolase domain 81296 - E set domains 49452 - Starch-binding domain-like | 0 | DIRECT |
52113,142921,47587 52113 - BRCT domain 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
81296,51445,51011 81296 - E set domains 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 0 | DIRECT |
51713,88802,88697 51713 - tRNA-guanine transglycosylase 88802 - Pre-PUA domain 88697 - PUA domain-like | 0 | DIRECT |
51445,51011,81296 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain 81296 - E set domains | 0 | DIRECT |
81296,81296,51445 81296 - E set domains 81296 - E set domains 51445 - (Trans)glycosidases | 0 | DIRECT |
51690,-9,-9 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like -9 - PDB -9 - PDB | 0 | DIRECT |
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
51445,69360,69360 51445 - (Trans)glycosidases 69360 - Cell wall binding repeat 69360 - Cell wall binding repeat | 0 | DIRECT |
52317,47648,52418 52317 - Class I glutamine amidotransferase-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
48403,47769,56399 48403 - Ankyrin repeat 47769 - SAM/Pointed domain 56399 - ADP-ribosylation | 0 | DIRECT |
50692,47648,52418 50692 - ADC-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
48403,48403,47769 48403 - Ankyrin repeat 48403 - Ankyrin repeat 47769 - SAM/Pointed domain | 0 | DIRECT |
48452,48452,48452 48452 - TPR-like 48452 - TPR-like 48452 - TPR-like | 0 | DIRECT |
52540,47648,52418 52540 - P-loop containing nucleoside triphosphate hydrolases 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
82829,56037,53271 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain 53271 - PRTase-like | 0 | DIRECT |
47648,52418,54680 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 54680 - Pyrimidine nucleoside phosphorylase C-terminal domain | 0 | DIRECT |
52402,82829,56037 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain | 0.6698 | INHERITED FROM: Hypoxanthine phosphoribosyltransferase |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
51011,81296,49452 51011 - Glycosyl hydrolase domain 81296 - E set domains 49452 - Starch-binding domain-like | 0 | Direct |
52113,142921,47587 52113 - BRCT domain 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
81296,51445,51011 81296 - E set domains 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 0 | Direct |
51713,88802,88697 51713 - tRNA-guanine transglycosylase 88802 - Pre-PUA domain 88697 - PUA domain-like | 0 | Direct |
51445,51011,81296 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain 81296 - E set domains | 0 | Direct |
81296,81296,51445 81296 - E set domains 81296 - E set domains 51445 - (Trans)glycosidases | 0 | Direct |
51690,-9,-9 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like -9 - PDB -9 - PDB | 0 | Direct |
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
51445,69360,69360 51445 - (Trans)glycosidases 69360 - Cell wall binding repeat 69360 - Cell wall binding repeat | 0 | Direct |
52317,47648,52418 52317 - Class I glutamine amidotransferase-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
48403,47769,56399 48403 - Ankyrin repeat 47769 - SAM/Pointed domain 56399 - ADP-ribosylation | 0 | Direct |
50692,47648,52418 50692 - ADC-like 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
48403,48403,47769 48403 - Ankyrin repeat 48403 - Ankyrin repeat 47769 - SAM/Pointed domain | 0 | Direct |
48452,48452,48452 48452 - TPR-like 48452 - TPR-like 48452 - TPR-like | 0 | Direct |
52540,47648,52418 52540 - P-loop containing nucleoside triphosphate hydrolases 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
82829,56037,53271 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain 53271 - PRTase-like | 0 | Direct |
47648,52418,54680 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 54680 - Pyrimidine nucleoside phosphorylase C-terminal domain | 0 | Direct |
52402,82829,56037 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain | 0.6698 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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