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Enzyme Commission (EC): Transferring alkyl or aryl groups, other than methyl groups
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Shortest distance to current term (+ for parents, - for children) |
EC term [EC ID] <#Children> |
(#SF|#FA) |
#Supra-domain (Single|Duplex|Triple) |
+ + + 3: | root [root] <7> |
+ + 2: | Transferases [2] <10> | (445|680) |
(444|535|275) |
+ 1: | Transferring alkyl or aryl groups, other than methyl groups [2.5] <1> | (43|47) |
(42|21|8) |
0: | Transferring alkyl or aryl groups, other than methyl groups [2.5.1] <161> | (42|46) |
(41|21|8) |
- 1: | (2E,6E)-farnesyl diphosphate synthase [2.5.1.10] | (1|1) |
(1|0|0) |
- 1: | (2Z,6E)-farnesyl diphosphate synthase [2.5.1.68] | (1|1) |
(1|0|0) |
- 1: | (2Z,6Z)-farnesyl diphosphate synthase [2.5.1.92] | (0|0) |
(0|0|0) |
- 1: | 1,4-dihydroxy-2-naphthoate polyprenyltransferase [2.5.1.74] | (0|0) |
(0|0|0) |
- 1: | 12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferase [2.5.1.110] | (0|0) |
(0|0|0) |
- 1: | 15-cis-phytoene synthase [2.5.1.32] | (1|1) |
(1|0|0) |
- 1: | 2-(3-amino-3-carboxypropyl)histidine synthase [2.5.1.108] | (0|0) |
(0|0|0) |
- 1: | 2-acyl-4-prenylphloroglucinol 6-prenyltransferase [2.5.1.137] | (0|0) |
(0|0|0) |
- 1: | 2-acylphloroglucinol 4-prenyltransferase [2.5.1.136] | (0|0) |
(0|0|0) |
- 1: | 2-carboxy-1,4-naphthoquinone phytyltransferase [2.5.1.130] | (0|0) |
(0|0|0) |
- 1: | 3-deoxy-7-phosphoheptulonate synthase [2.5.1.54] | (2|2) |
(1|1|0) |
- 1: | 3-deoxy-8-phosphooctulonate synthase [2.5.1.55] | (1|1) |
(1|0|0) |
- 1: | 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase [2.5.1.132] | (0|0) |
(0|0|0) |
- 1: | 3-geranyl-3-((Z)-2-isocyanoethenyl)indole synthase [2.5.1.146] | (0|0) |
(0|0|0) |
- 1: | 3-phosphoshikimate 1-carboxyvinyltransferase [2.5.1.19] | (5|6) |
(5|5|4) |
- 1: | 4,4'-diapophytoene synthase [2.5.1.96] | (1|0) |
(1|0|0) |
- 1: | 4-O-dimethylallyl-L-tyrosine synthase [2.5.1.122] | (0|0) |
(0|0|0) |
- 1: | 4-dimethylallyltryptophan synthase [2.5.1.34] | (0|0) |
(0|0|0) |
- 1: | 4-hydroxybenzoate geranyltransferase [2.5.1.93] | (0|0) |
(0|0|0) |
- 1: | 4-hydroxybenzoate polyprenyltransferase [2.5.1.39] | (0|0) |
(0|0|0) |
- 1: | 4-hydroxyphenylpyruvate 3-dimethylallyltransferase [2.5.1.111] | (0|0) |
(0|0|0) |
- 1: | 5'-phosphate synthase [2.5.1.105] | (0|0) |
(0|0|0) |
- 1: | 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase [2.5.1.121] | (0|0) |
(0|0|0) |
- 1: | 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase [2.5.1.147] | (1|1) |
(1|0|0) |
- 1: | 6,7-dimethyl-8-ribityllumazine synthase [2.5.1.78] | (1|1) |
(1|0|0) |
- 1: | 6-linalyl-2-O,3-dimethylflaviolin synthase [2.5.1.124] | (0|0) |
(0|0|0) |
- 1: | 7-dimethylallyltryptophan synthase [2.5.1.80] | (0|0) |
(0|0|0) |
- 1: | 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase [2.5.1.125] | (0|0) |
(0|0|0) |
- 1: | Adenosyl-chloride synthase [2.5.1.94] | (0|0) |
(0|0|0) |
- 1: | Adenosyl-fluoride synthase [2.5.1.63] | (0|0) |
(0|0|0) |
- 1: | Adenosylmethionine cyclotransferase [2.5.1.4] | (0|0) |
(0|0|0) |
- 1: | Adenylate dimethylallyltransferase (ADP/ATP-dependent) [2.5.1.112] | (1|0) |
(1|0|0) |
- 1: | Adenylate dimethylallyltransferase (AMP-dependent) [2.5.1.27] | (1|0) |
(1|0|0) |
- 1: | Alkylcobalamin dealkylase [2.5.1.151] | (0|0) |
(0|0|0) |
- 1: | Alkylglycerone-phosphate synthase [2.5.1.26] | (2|1) |
(2|1|0) |
- 1: | All-trans-decaprenyl-diphosphate synthase [2.5.1.91] | (1|1) |
(1|0|0) |
- 1: | All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) [2.5.1.84] | (1|1) |
(1|0|0) |
- 1: | All-trans-octaprenyl-diphosphate synthase [2.5.1.90] | (0|0) |
(0|0|0) |
- 1: | Aminodeoxyfutalosine synthase [2.5.1.120] | (0|0) |
(0|0|0) |
- 1: | Aspulvinone dimethylallyltransferase [2.5.1.35] | (0|0) |
(0|0|0) |
- 1: | Bacteriochlorophyll a synthase [2.5.1.133] | (0|0) |
(0|0|0) |
- 1: | Beta-(isoxazolin-5-on-2-yl)-L-alanine synthase [2.5.1.118] | (0|0) |
(0|0|0) |
- 1: | Beta-(isoxazolin-5-on-4-yl)-L-alanine synthase [2.5.1.119] | (0|0) |
(0|0|0) |
- 1: | Beta-pyrazolylalanine synthase [2.5.1.51] | (0|0) |
(0|0|0) |
- 1: | Brevianamide F prenyltransferase (deoxybrevianamide E-forming) [2.5.1.109] | (0|0) |
(0|0|0) |
- 1: | Caldopentamine synthase [2.5.1.127] | (0|0) |
(0|0|0) |
- 1: | Chlorophyll synthase [2.5.1.62] | (0|0) |
(0|0|0) |
- 1: | Chrysanthemyl diphosphate synthase [2.5.1.67] | (0|0) |
(0|0|0) |
- 1: | Corrinoid adenosyltransferase [2.5.1.17] | (1|2) |
(1|0|0) |
- 1: | Coumarin 8-geranyltransferase [2.5.1.138] | (0|0) |
(0|0|0) |
- 1: | Cystathionine beta-synthase (O-acetyl-L-serine) [2.5.1.134] | (0|0) |
(0|0|0) |
- 1: | Cystathionine gamma-synthase [2.5.1.48] | (1|1) |
(1|0|0) |
- 1: | Cysteate synthase [2.5.1.76] | (1|1) |
(1|0|0) |
- 1: | Cysteine synthase [2.5.1.47] | (1|1) |
(1|0|0) |
- 1: | D-histidine 2-aminobutanoyltransferase [2.5.1.152] | (0|0) |
(0|0|0) |
- 1: | Deleted entry [2.5.1.99] | (0|0) |
(0|0|0) |
- 1: | Deoxyhypusine synthase [2.5.1.46] | (1|1) |
(1|0|0) |
- 1: | Dihydropteroate synthase [2.5.1.15] | (3|3) |
(3|3|2) |
- 1: | Dimethylallylcistransferase [2.5.1.28] | (0|0) |
(0|0|0) |
- 1: | Dimethylallyltranstransferase [2.5.1.1] | (1|1) |
(1|0|0) |
- 1: | Discadenine synthase [2.5.1.24] | (0|0) |
(0|0|0) |
- 1: | Flavin prenyltransferase [2.5.1.129] | (1|1) |
(1|0|0) |
- 1: | Flaviolin linalyltransferase [2.5.1.123] | (0|0) |
(0|0|0) |
- 1: | Fumigaclavine A dimethylallyltransferase [2.5.1.100] | (0|0) |
(0|0|0) |
- 1: | Galactose-6-sulfurylase [2.5.1.5] | (0|0) |
(0|0|0) |
- 1: | Geranylfarnesyl diphosphate synthase [2.5.1.81] | (1|1) |
(1|0|0) |
- 1: | Geranylgeranyl diphosphate synthase [2.5.1.29] | (1|1) |
(1|0|0) |
- 1: | Geranylgeranylglycerol-phosphate geranylgeranyltransferase [2.5.1.42] | (0|0) |
(0|0|0) |
- 1: | Geranylpyrophosphate--olivetolic acid geranyltransferase [2.5.1.102] | (0|0) |
(0|0|0) |
- 1: | Glutathione transferase [2.5.1.18] | (4|5) |
(4|1|0) |
- 1: | Heme o synthase [2.5.1.141] | (1|0) |
(1|0|0) |
- 1: | Heptaprenyl diphosphate synthase [2.5.1.30] | (0|0) |
(0|0|0) |
- 1: | Heptaprenylglyceryl phosphate synthase [2.5.1.n9] | (1|1) |
(1|0|0) |
- 1: | Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) [2.5.1.82] | (0|0) |
(0|0|0) |
- 1: | Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [2.5.1.83] | (0|0) |
(0|0|0) |
- 1: | Homogentisate geranylgeranyltransferase [2.5.1.116] | (0|0) |
(0|0|0) |
- 1: | Homogentisate phytyltransferase [2.5.1.115] | (0|0) |
(0|0|0) |
- 1: | Homogentisate solanesyltransferase [2.5.1.117] | (0|0) |
(0|0|0) |
- 1: | Homospermidine synthase [2.5.1.44] | (0|0) |
(0|0|0) |
- 1: | Homospermidine synthase (spermidine-specific) [2.5.1.45] | (1|1) |
(1|0|0) |
- 1: | Hydroxymethylbilane synthase [2.5.1.61] | (2|2) |
(2|1|0) |
- 1: | Isonocardicin synthase [2.5.1.38] | (0|0) |
(0|0|0) |
- 1: | L-mimosine synthase [2.5.1.52] | (0|0) |
(0|0|0) |
- 1: | Lavandulyl diphosphate synthase [2.5.1.69] | (0|0) |
(0|0|0) |
- 1: | Leachianone-G 2''-dimethylallyltransferase [2.5.1.71] | (0|0) |
(0|0|0) |
- 1: | Lycopaoctaene synthase [2.5.1.148] | (0|0) |
(0|0|0) |
- 1: | Lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming) [2.5.1.150] | (0|0) |
(0|0|0) |
- 1: | Lycopene elongase/hydratase (flavuxanthin-forming) [2.5.1.149] | (0|0) |
(0|0|0) |
- 1: | Methionine adenosyltransferase [2.5.1.6] | (1|1) |
(1|1|1) |
- 1: | N(1)-aminopropylagmatine synthase [2.5.1.104] | (0|0) |
(0|0|0) |
- 1: | N(2)-(2-carboxyethyl)arginine synthase [2.5.1.66] | (0|0) |
(0|0|0) |
- 1: | N(4)-bis(aminopropyl)spermidine synthase [2.5.1.128] | (1|0) |
(1|0|0) |
- 1: | N,N'-diacetyllegionaminate synthase [2.5.1.101] | (0|0) |
(0|0|0) |
- 1: | N-(2-amino-2-carboxyethyl)-L-glutamate synthase [2.5.1.140] | (1|1) |
(1|0|0) |
- 1: | N-acetylneuraminate synthase [2.5.1.56] | (0|0) |
(0|0|0) |
- 1: | N-acylneuraminate-9-phosphate synthase [2.5.1.57] | (2|2) |
(2|1|0) |
- 1: | Naringenin 8-dimethylallyltransferase [2.5.1.70] | (0|0) |
(0|0|0) |
- 1: | Nerylneryl diphosphate synthase [2.5.1.142] | (0|0) |
(0|0|0) |
- 1: | Nicotianamine synthase [2.5.1.43] | (1|0) |
(1|0|0) |
- 1: | Norspermine synthase [2.5.1.126] | (1|1) |
(1|0|0) |
- 1: | O-acetylhomoserine aminocarboxypropyltransferase [2.5.1.49] | (1|1) |
(1|0|0) |
- 1: | O-phospho-L-seryl-tRNA:Cys-tRNA synthase [2.5.1.73] | (1|1) |
(1|0|0) |
- 1: | O-phosphoserine sulfhydrylase [2.5.1.65] | (0|0) |
(0|0|0) |
- 1: | Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase [2.5.1.145] | (0|0) |
(0|0|0) |
- 1: | Phosphoglycerol geranylgeranyltransferase [2.5.1.41] | (1|1) |
(1|0|0) |
- 1: | Presqualene diphosphate synthase [2.5.1.103] | (1|0) |
(1|0|0) |
- 1: | Protein farnesyltransferase [2.5.1.58] | (2|2) |
(2|0|0) |
- 1: | Protein geranylgeranyltransferase type I [2.5.1.59] | (2|2) |
(2|0|0) |
- 1: | Protein geranylgeranyltransferase type II [2.5.1.60] | (5|4) |
(5|2|1) |
- 1: | Pseudaminic acid synthase [2.5.1.97] | (2|2) |
(2|1|0) |
- 1: | Pyridinium-3,5-biscarboxylic acid mononucleotide synthase [2.5.1.143] | (0|0) |
(0|0|0) |
- 1: | Quinolinate synthase [2.5.1.72] | (1|1) |
(1|0|0) |
- 1: | Riboflavin synthase [2.5.1.9] | (1|1) |
(1|1|0) |
- 1: | Rubber cis-polyprenylcistransferase [2.5.1.20] | (0|0) |
(0|0|0) |
- 1: | S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) [2.5.1.144] | (0|0) |
(0|0|0) |
- 1: | Spermidine synthase [2.5.1.16] | (2|1) |
(2|1|0) |
- 1: | Spermine synthase [2.5.1.22] | (1|1) |
(1|0|0) |
- 1: | Squalene synthase [2.5.1.21] | (1|1) |
(1|0|0) |
- 1: | Sym-norspermidine synthase [2.5.1.23] | (1|1) |
(1|0|0) |
- 1: | Thermospermine synthase [2.5.1.79] | (1|1) |
(1|0|0) |
- 1: | Thiamine phosphate synthase [2.5.1.3] | (2|3) |
(2|2|0) |
- 1: | Thiamine pyridinylase [2.5.1.2] | (0|0) |
(0|0|0) |
- 1: | Trans,polycis-decaprenyl diphosphate synthase [2.5.1.86] | (1|1) |
(1|0|0) |
- 1: | Transferred entry: 2.2.1.9 [2.5.1.n1] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.2.1.9 and 4.2.99.20 [2.5.1.64] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.105 [2.5.1.n6] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.108 [2.5.1.n7] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.112 [2.5.1.n4] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.113 [2.5.1.n5] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.115 [2.5.1.n8] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.147 [2.5.1.77] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.18 [2.5.1.14] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.18 [2.5.1.13] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.18 [2.5.1.12] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.73 [2.5.1.n3] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.75 [2.5.1.8] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.81 [2.5.1.n2] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.82 and 2.5.1.83 [2.5.1.33] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 2.5.1.84 and 2.5.1.85 [2.5.1.11] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 4.2.3.9 [2.5.1.40] | (0|0) |
(0|0|0) |
- 1: | Transferred entry: 4.4.1.20 [2.5.1.37] | (0|0) |
(0|0|0) |
- 1: | Trihydroxypterocarpan dimethylallyltransferase [2.5.1.36] | (0|0) |
(0|0|0) |
- 1: | Tryprostatin B synthase [2.5.1.106] | (0|0) |
(0|0|0) |
- 1: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase [2.5.1.7] | (1|1) |
(1|0|0) |
- 1: | Umbelliferone 6-dimethylallyltransferase [2.5.1.139] | (0|0) |
(0|0|0) |
- 1: | Uracilylalanine synthase [2.5.1.53] | (0|0) |
(0|0|0) |
- 1: | Validamine 7-phosphate valienyltransferase [2.5.1.135] | (0|0) |
(0|0|0) |
- 1: | Verruculogen prenyltransferase [2.5.1.107] | (0|0) |
(0|0|0) |
- 1: | Xanthan pyruvate transferase [2.5.1.95] | (0|0) |
(0|0|0) |
- 1: | Zeatin 9-aminocarboxyethyltransferase [2.5.1.50] | (0|0) |
(0|0|0) |
- 1: | diphosphate specific) [2.5.1.89] | (1|1) |
(1|0|0) |
- 1: | diphosphate specific) [2.5.1.31] | (1|1) |
(1|0|0) |
- 1: | diphosphate specific) [2.5.1.87] | (1|1) |
(1|0|0) |
- 1: | diphosphate specific) [2.5.1.88] | (0|0) |
(0|0|0) |
- 1: | specific) [2.5.1.85] | (1|1) |
(1|0|0) |
- 1: | synthase [2.5.1.113] | (0|0) |
(0|0|0) |
- 1: | tRNA dimethylallyltransferase [2.5.1.75] | (1|0) |
(1|1|0) |
- 1: | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase [2.5.1.114] | (1|1) |
(1|0|0) |
- 1: | tRNA-uridine aminocarboxypropyltransferase [2.5.1.25] | (0|0) |
(0|0|0) |
- 1: | transferase [2.5.1.98] | (0|0) |
(0|0|0) |
- 1: | yl)methanamine synthase [2.5.1.131] | (0|0) |
(0|0|0) |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Ribokinase-like | 1 | INHERITED FROM: Thiamine phosphate synthase |
LanC-like | 1 | INHERITED FROM: Glutathione transferase |
EPT/RTPC-like | 1 | INHERITED FROM: UDP-N-acetylglucosamine 1-carboxyvinyltransferase || 3-phosphoshikimate 1-carboxyvinyltransferase |
Thioredoxin-like | 1 | INHERITED FROM: Glutathione transferase |
DHS-like NAD/FAD-binding domain | 1 | INHERITED FROM: Deoxyhypusine synthase || Homospermidine synthase (spermidine-specific) |
Radical SAM enzymes | 1 | INHERITED FROM: 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase |
L domain-like | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | INHERITED FROM: Dihydropteroate synthase |
Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydropteroate synthase |
Terpenoid cyclases/Protein prenyltransferases | 1 | INHERITED FROM: Protein farnesyltransferase || Protein geranylgeranyltransferase type I || Protein geranylgeranyltransferase type II |
FMN-linked oxidoreductases | 1 | INHERITED FROM: Phosphoglycerol geranylgeranyltransferase || Heptaprenylglyceryl phosphate synthase |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Nicotianamine synthase || Norspermine synthase || Spermidine synthase || Sym-norspermidine synthase || tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase || N(4)-bis(aminopropyl)spermidine synthase || Thermospermine synthase || Spermine synthase |
S-adenosylmethionine synthetase | 1 | INHERITED FROM: Methionine adenosyltransferase |
NadA-like | 1 | INHERITED FROM: Quinolinate synthase |
Outer arm dynein light chain 1 | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 1 | INHERITED FROM: Flavin prenyltransferase |
Protein prenylyltransferase | 1 | INHERITED FROM: Protein farnesyltransferase || Protein geranylgeranyltransferase type I || Protein geranylgeranyltransferase type II |
FAD-linked oxidases, C-terminal domain | 1 | INHERITED FROM: Alkylglycerone-phosphate synthase |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: N-(2-amino-2-carboxyethyl)-L-glutamate synthase || Cysteine synthase || Cysteate synthase |
Undecaprenyl diphosphate synthase | 1 | INHERITED FROM: diphosphate specific) || diphosphate specific) || diphosphate specific) || Trans,polycis-decaprenyl diphosphate synthase || (2Z,6E)-farnesyl diphosphate synthase |
Riboflavin synthase domain-like | 1 | INHERITED FROM: Riboflavin synthase |
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
PLP-dependent transferases | 1 | INHERITED FROM: Cystathionine gamma-synthase || O-acetylhomoserine aminocarboxypropyltransferase || O-phospho-L-seryl-tRNA:Cys-tRNA synthase |
Aldolase | 1 | INHERITED FROM: 3-deoxy-8-phosphooctulonate synthase || N-acylneuraminate-9-phosphate synthase || Pseudaminic acid synthase || 3-deoxy-7-phosphoheptulonate synthase || 3-phosphoshikimate 1-carboxyvinyltransferase |
GST C-terminal domain-like | 1 | INHERITED FROM: Glutathione transferase |
Rab geranylgeranyltransferase alpha-subunit, insert domain | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Dihydropteroate synthase |
Cobalamin adenosyltransferase-like | 1 | INHERITED FROM: Corrinoid adenosyltransferase |
Lumazine synthase | 1 | INHERITED FROM: 6,7-dimethyl-8-ribityllumazine synthase |
P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Adenylate dimethylallyltransferase (ADP/ATP-dependent) || Adenylate dimethylallyltransferase (AMP-dependent) || tRNA dimethylallyltransferase |
Multidrug efflux transporter AcrB transmembrane domain | 1 | INHERITED FROM: Heme o synthase |
SCOP hierarchy in SUPERFAMILY | 1 | INHERITED FROM: 3-deoxy-7-phosphoheptulonate synthase |
MFS general substrate transporter | 1 | INHERITED FROM: Spermidine synthase |
NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
Periplasmic binding protein-like II | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
MAPEG domain-like | 1 | INHERITED FROM: Glutathione transferase |
Dehydroquinate synthase-like | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
Thiamin phosphate synthase | 1 | INHERITED FROM: Thiamine phosphate synthase |
FAD-binding/transporter-associated domain-like | 1 | INHERITED FROM: Alkylglycerone-phosphate synthase |
Terpenoid synthases | 1 | INHERITED FROM: Squalene synthase || (2E,6E)-farnesyl diphosphate synthase || 4,4'-diapophytoene synthase || All-trans-decaprenyl-diphosphate synthase || Dimethylallyltranstransferase || specific) || All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) || 15-cis-phytoene synthase || Presqualene diphosphate synthase || Geranylfarnesyl diphosphate synthase || Geranylgeranyl diphosphate synthase |
AFP III-like domain | 1 | INHERITED FROM: N-acylneuraminate-9-phosphate synthase || Pseudaminic acid synthase |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Glutathione S-transferase (GST), C-terminal domain | 1 | INHERITED FROM: Glutathione transferase |
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 1 | INHERITED FROM: Flavin prenyltransferase |
Phosphomethylpyrimidine kinase C-terminal domain-like | 1 | INHERITED FROM: Thiamine phosphate synthase |
Shikimate kinase (AroK) | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
Riboflavin synthase | 1 | INHERITED FROM: Riboflavin synthase |
Rab geranylgeranyltransferase alpha-subunit, insert domain | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Isoprenyl diphosphate synthases | 1 | INHERITED FROM: (2E,6E)-farnesyl diphosphate synthase || All-trans-decaprenyl-diphosphate synthase || Dimethylallyltranstransferase || specific) || All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) || Geranylfarnesyl diphosphate synthase || Geranylgeranyl diphosphate synthase |
Class I aldolase | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
SepSecS-like | 1 | INHERITED FROM: O-phospho-L-seryl-tRNA:Cys-tRNA synthase |
Cobalamin adenosyltransferase | 1 | INHERITED FROM: Corrinoid adenosyltransferase |
MAPEG domain | 1 | INHERITED FROM: Glutathione transferase |
Dehydroquinate synthase, DHQS | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
AFP III-like domain | 1 | INHERITED FROM: N-acylneuraminate-9-phosphate synthase || Pseudaminic acid synthase |
Phosphate binding protein-like | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
FMN-linked oxidoreductases | 1 | INHERITED FROM: Phosphoglycerol geranylgeranyltransferase || Heptaprenylglyceryl phosphate synthase |
Protein prenylyltransferase | 1 | INHERITED FROM: Protein farnesyltransferase || Protein geranylgeranyltransferase type I || Protein geranylgeranyltransferase type II |
Met-10+ protein-like | 1 | INHERITED FROM: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase |
Undecaprenyl diphosphate synthase | 1 | INHERITED FROM: diphosphate specific) || diphosphate specific) || diphosphate specific) || Trans,polycis-decaprenyl diphosphate synthase || (2Z,6E)-farnesyl diphosphate synthase |
NadA-like | 1 | INHERITED FROM: Quinolinate synthase |
Squalene synthase | 1 | INHERITED FROM: Squalene synthase || 15-cis-phytoene synthase |
Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
Protein prenyltransferases | 1 | INHERITED FROM: Protein farnesyltransferase || Protein geranylgeranyltransferase type I || Protein geranylgeranyltransferase type II |
RecA protein-like (ATPase-domain) | 1 | INHERITED FROM: Corrinoid adenosyltransferase |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: N-(2-amino-2-carboxyethyl)-L-glutamate synthase || Cysteine synthase || Cysteate synthase |
Enolpyruvate transferase, EPT | 1 | INHERITED FROM: UDP-N-acetylglucosamine 1-carboxyvinyltransferase || 3-phosphoshikimate 1-carboxyvinyltransferase |
Deoxyhypusine synthase, DHS | 1 | INHERITED FROM: Deoxyhypusine synthase || Homospermidine synthase (spermidine-specific) |
FAD-linked oxidases, N-terminal domain | 1 | INHERITED FROM: Alkylglycerone-phosphate synthase |
Lumazine synthase | 1 | INHERITED FROM: 6,7-dimethyl-8-ribityllumazine synthase |
Thiamin biosynthesis kinases | 1 | INHERITED FROM: Thiamine phosphate synthase |
Dihydropteroate synthetase | 1 | INHERITED FROM: Dihydropteroate synthase |
Cystathionine synthase-like | 1 | INHERITED FROM: Cystathionine gamma-synthase || O-acetylhomoserine aminocarboxypropyltransferase |
Outer arm dynein light chain 1 | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Biotin synthase | 1 | INHERITED FROM: 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase |
Spermidine synthase | 1 | INHERITED FROM: Norspermine synthase || Spermidine synthase || Sym-norspermidine synthase || Thermospermine synthase || Spermine synthase |
Thiamin phosphate synthase | 1 | INHERITED FROM: Thiamine phosphate synthase |
NeuB-like | 1 | INHERITED FROM: N-acylneuraminate-9-phosphate synthase || Pseudaminic acid synthase |
DsbA-like | 1 | INHERITED FROM: Glutathione transferase |
LanC-like | 1 | INHERITED FROM: Glutathione transferase |
Class-II DAHP synthetase | 1 | INHERITED FROM: 3-deoxy-7-phosphoheptulonate synthase |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | INHERITED FROM: Dihydropteroate synthase |
Shikimate dehydrogenase-like | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
S-adenosylmethionine synthetase | 1 | INHERITED FROM: Methionine adenosyltransferase |
Glutathione S-transferase (GST), N-terminal domain | 1 | INHERITED FROM: Glutathione transferase |
DHN aldolase/epimerase | 1 | INHERITED FROM: Dihydropteroate synthase |
Class I DAHP synthetase | 1 | INHERITED FROM: 3-deoxy-8-phosphooctulonate synthase || 3-deoxy-7-phosphoheptulonate synthase |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Glutathione S-transferase (GST), C-terminal domain | 1 | Inherited |
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | Inherited |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 1 | Inherited |
Phosphomethylpyrimidine kinase C-terminal domain-like | 1 | Inherited |
Shikimate kinase (AroK) | 1 | Inherited |
Riboflavin synthase | 1 | Inherited |
Rab geranylgeranyltransferase alpha-subunit, insert domain | 1 | Inherited |
Isoprenyl diphosphate synthases | 1 | Inherited |
Class I aldolase | 1 | Inherited |
SepSecS-like | 1 | Inherited |
Cobalamin adenosyltransferase | 1 | Inherited |
MAPEG domain | 1 | Inherited |
Dehydroquinate synthase, DHQS | 1 | Inherited |
AFP III-like domain | 1 | Inherited |
Phosphate binding protein-like | 1 | Inherited |
FMN-linked oxidoreductases | 1 | Inherited |
Protein prenylyltransferase | 1 | Inherited |
Met-10+ protein-like | 1 | Inherited |
Undecaprenyl diphosphate synthase | 1 | Inherited |
NadA-like | 1 | Inherited |
Squalene synthase | 1 | Inherited |
Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
Protein prenyltransferases | 1 | Inherited |
RecA protein-like (ATPase-domain) | 1 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
Enolpyruvate transferase, EPT | 1 | Inherited |
Deoxyhypusine synthase, DHS | 1 | Inherited |
FAD-linked oxidases, N-terminal domain | 1 | Inherited |
Lumazine synthase | 1 | Inherited |
Thiamin biosynthesis kinases | 1 | Inherited |
Dihydropteroate synthetase | 1 | Inherited |
Cystathionine synthase-like | 1 | Inherited |
Outer arm dynein light chain 1 | 1 | Inherited |
Biotin synthase | 1 | Inherited |
Spermidine synthase | 1 | Inherited |
Thiamin phosphate synthase | 1 | Inherited |
NeuB-like | 1 | Inherited |
DsbA-like | 1 | Inherited |
LanC-like | 1 | Inherited |
Class-II DAHP synthetase | 1 | Inherited |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | Inherited |
Shikimate dehydrogenase-like | 1 | Inherited |
S-adenosylmethionine synthetase | 1 | Inherited |
Glutathione S-transferase (GST), N-terminal domain | 1 | Inherited |
DHN aldolase/epimerase | 1 | Inherited |
Class I DAHP synthetase | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
PLP-dependent transferases | 1 | INHERITED FROM: O-phospho-L-seryl-tRNA:Cys-tRNA synthase || Cystathionine gamma-synthase || O-acetylhomoserine aminocarboxypropyltransferase |
Dehydroquinate synthase-like | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
Terpenoid synthases | 1 | INHERITED FROM: 4,4'-diapophytoene synthase || All-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) || specific) || All-trans-decaprenyl-diphosphate synthase || (2E,6E)-farnesyl diphosphate synthase || Presqualene diphosphate synthase || Geranylgeranyl diphosphate synthase || Geranylfarnesyl diphosphate synthase || Dimethylallyltranstransferase || 15-cis-phytoene synthase || Squalene synthase |
Thioredoxin-like | 1 | INHERITED FROM: Glutathione transferase |
Ribokinase-like | 1 | INHERITED FROM: Thiamine phosphate synthase |
Radical SAM enzymes | 1 | INHERITED FROM: 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase |
Aldolase | 1 | INHERITED FROM: N-acylneuraminate-9-phosphate synthase || 3-deoxy-8-phosphooctulonate synthase || 3-phosphoshikimate 1-carboxyvinyltransferase || 3-deoxy-7-phosphoheptulonate synthase || Pseudaminic acid synthase |
Multidrug efflux transporter AcrB transmembrane domain | 1 | INHERITED FROM: Heme o synthase |
MFS general substrate transporter | 1 | INHERITED FROM: Spermidine synthase |
FMN-linked oxidoreductases | 1 | INHERITED FROM: Phosphoglycerol geranylgeranyltransferase || Heptaprenylglyceryl phosphate synthase |
LanC-like | 1 | INHERITED FROM: Glutathione transferase |
Periplasmic binding protein-like II | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
Terpenoid cyclases/Protein prenyltransferases | 1 | INHERITED FROM: Protein geranylgeranyltransferase type I || Protein geranylgeranyltransferase type II || Protein farnesyltransferase |
Cobalamin adenosyltransferase-like | 1 | INHERITED FROM: Corrinoid adenosyltransferase |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | INHERITED FROM: Dihydropteroate synthase |
GST C-terminal domain-like | 1 | INHERITED FROM: Glutathione transferase |
NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
MAPEG domain-like | 1 | INHERITED FROM: Glutathione transferase |
P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: tRNA dimethylallyltransferase || Adenylate dimethylallyltransferase (ADP/ATP-dependent) || Adenylate dimethylallyltransferase (AMP-dependent) |
Thiamin phosphate synthase | 1 | INHERITED FROM: Thiamine phosphate synthase |
Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
Rab geranylgeranyltransferase alpha-subunit, insert domain | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 1 | INHERITED FROM: Flavin prenyltransferase |
EPT/RTPC-like | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase || UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
DHS-like NAD/FAD-binding domain | 1 | INHERITED FROM: Homospermidine synthase (spermidine-specific) || Deoxyhypusine synthase |
Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydropteroate synthase |
FAD-binding/transporter-associated domain-like | 1 | INHERITED FROM: Alkylglycerone-phosphate synthase |
Riboflavin synthase domain-like | 1 | INHERITED FROM: Riboflavin synthase |
FAD-linked oxidases, C-terminal domain | 1 | INHERITED FROM: Alkylglycerone-phosphate synthase |
Protein prenylyltransferase | 1 | INHERITED FROM: Protein geranylgeranyltransferase type I || Protein geranylgeranyltransferase type II || Protein farnesyltransferase |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Cysteate synthase || N-(2-amino-2-carboxyethyl)-L-glutamate synthase || Cysteine synthase |
L domain-like | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
NadA-like | 1 | INHERITED FROM: Quinolinate synthase |
Undecaprenyl diphosphate synthase | 1 | INHERITED FROM: diphosphate specific) || diphosphate specific) || diphosphate specific) || (2Z,6E)-farnesyl diphosphate synthase || Trans,polycis-decaprenyl diphosphate synthase |
Lumazine synthase | 1 | INHERITED FROM: 6,7-dimethyl-8-ribityllumazine synthase |
Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Dihydropteroate synthase |
S-adenosylmethionine synthetase | 1 | INHERITED FROM: Methionine adenosyltransferase |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Norspermine synthase || tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase || Sym-norspermidine synthase || Spermidine synthase || Spermine synthase || Nicotianamine synthase || N(4)-bis(aminopropyl)spermidine synthase || Thermospermine synthase |
AFP III-like domain | 1 | INHERITED FROM: N-acylneuraminate-9-phosphate synthase || Pseudaminic acid synthase |
Outer arm dynein light chain 1 | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
55620,55620 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Dihydropteroate synthase |
55083,51717 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK 51717 - Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydropteroate synthase |
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain | 1 | INHERITED FROM: Alkylglycerone-phosphate synthase |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: tRNA dimethylallyltransferase |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 1 | INHERITED FROM: Methionine adenosyltransferase |
51569,51269 51569 - Aldolase 51269 - AFP III-like domain | 1 | INHERITED FROM: N-acylneuraminate-9-phosphate synthase || Pseudaminic acid synthase |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
51391,53613 51391 - Thiamin phosphate synthase 53613 - Ribokinase-like | 1 | INHERITED FROM: Thiamine phosphate synthase |
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like | 1 | INHERITED FROM: Glutathione transferase |
53850,54782 53850 - Periplasmic binding protein-like II 54782 - Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | INHERITED FROM: Hydroxymethylbilane synthase |
-9,51569 -9 - PDB 51569 - Aldolase | 1 | INHERITED FROM: 3-deoxy-7-phosphoheptulonate synthase |
55620,55083 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | INHERITED FROM: Dihydropteroate synthase |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
48439,49594 48439 - Protein prenylyltransferase 49594 - Rab geranylgeranyltransferase alpha-subunit, insert domain | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
63380,63380 63380 - Riboflavin synthase domain-like 63380 - Riboflavin synthase domain-like | 1 | INHERITED FROM: Riboflavin synthase |
103473,53335 103473 - MFS general substrate transporter 53335 - S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Spermidine synthase |
49594,52075 49594 - Rab geranylgeranyltransferase alpha-subunit, insert domain 52075 - Outer arm dynein light chain 1 | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
53613,51391 53613 - Ribokinase-like 51391 - Thiamin phosphate synthase | 1 | INHERITED FROM: Thiamine phosphate synthase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 1 | Inherited |
55620,55620 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
55083,51717 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK 51717 - Dihydropteroate synthetase-like | 1 | Inherited |
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain | 1 | Inherited |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 1 | Inherited |
51569,51269 51569 - Aldolase 51269 - AFP III-like domain | 1 | Inherited |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 1 | Inherited |
51391,53613 51391 - Thiamin phosphate synthase 53613 - Ribokinase-like | 1 | Inherited |
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like | 1 | Inherited |
53850,54782 53850 - Periplasmic binding protein-like II 54782 - Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | Inherited |
-9,51569 -9 - PDB 51569 - Aldolase | 1 | Inherited |
55620,55083 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | Inherited |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
48439,49594 48439 - Protein prenylyltransferase 49594 - Rab geranylgeranyltransferase alpha-subunit, insert domain | 1 | Inherited |
63380,63380 63380 - Riboflavin synthase domain-like 63380 - Riboflavin synthase domain-like | 1 | Inherited |
103473,53335 103473 - MFS general substrate transporter 53335 - S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
49594,52075 49594 - Rab geranylgeranyltransferase alpha-subunit, insert domain 52075 - Outer arm dynein light chain 1 | 1 | Inherited |
53613,51391 53613 - Ribokinase-like 51391 - Thiamin phosphate synthase | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
55620,55083,51717 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK 51717 - Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydropteroate synthase |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase |
55620,55620,55083 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | INHERITED FROM: Dihydropteroate synthase |
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 1 | INHERITED FROM: Methionine adenosyltransferase |
48439,49594,52075 48439 - Protein prenylyltransferase 49594 - Rab geranylgeranyltransferase alpha-subunit, insert domain 52075 - Outer arm dynein light chain 1 | 1 | INHERITED FROM: Protein geranylgeranyltransferase type II |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
55620,55083,51717 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK 51717 - Dihydropteroate synthetase-like | 1 | Inherited |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 1 | Inherited |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
55620,55620,55083 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55620 - Tetrahydrobiopterin biosynthesis enzymes-like 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 1 | Inherited |
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 1 | Inherited |
48439,49594,52075 48439 - Protein prenylyltransferase 49594 - Rab geranylgeranyltransferase alpha-subunit, insert domain 52075 - Outer arm dynein light chain 1 | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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