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Enzyme Commission (EC): Phosphotransferases with an alcohol group as acceptor
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Ribokinase-like | 0 | DIRECT |
SAICAR synthase-like | 0 | DIRECT |
ApbE-like | 0 | DIRECT |
Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
Riboflavin kinase-like | 0 | DIRECT |
DAK1/DegV-like | 0 | DIRECT |
PK C-terminal domain-like | 0 | DIRECT |
NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
Glycerate kinase I | 0 | DIRECT |
Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
GHMP Kinase, C-terminal domain | 0 | DIRECT |
GckA/TtuD-like | 0 | DIRECT |
YgbK-like | 0 | DIRECT |
PTS system fructose IIA component-like | 0 | DIRECT |
Phosphofructokinase | 0 | DIRECT |
PTS IIb component | 0 | DIRECT |
Actin-like ATPase domain | 0 | DIRECT |
P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
Glucose permease domain IIB | 0 | DIRECT |
Ribosomal protein S5 domain 2-like | 0 | DIRECT |
PK beta-barrel domain-like | 0 | DIRECT |
Trm112p-like | 0 | DIRECT |
PTS system IIB component-like | 0 | DIRECT |
DhaL-like | 0 | DIRECT |
Dehydroquinate synthase-like | 0.0000000000003125 | DIRECT |
GroEL apical domain-like | 0.000000000001841 | DIRECT |
Duplicated hybrid motif | 0.000000000001991 | DIRECT |
Phoshotransferase/anion transport protein | 0.000000000007466 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0.0000001936 | DIRECT |
Ubiquitin-like | 0.0000004051 | DIRECT |
HPr-like | 0.00000676 | DIRECT |
Homeodomain-like | 0.00001413 | DIRECT |
ARM repeat | 0.0000353 | DIRECT |
ADP-ribosylation | 0.00003617 | DIRECT |
C-terminal domain of transcriptional repressors | 0.0001396 | DIRECT |
GroEL-intermediate domain like | 0.0002409 | DIRECT |
EPT/RTPC-like | 0.0006447 | DIRECT |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.003161 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase || Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase |
PX domain | 0.003564 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
Phosphoglycerate mutase-like | 0.009531 | INHERITED FROM: 6-phosphofructo-2-kinase |
FYVE/PHD zinc finger | 0.04425 | INHERITED FROM: 1-phosphatidylinositol-3-phosphate 5-kinase |
Heme oxygenase-like | 0.05429 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
Aminoacid dehydrogenase-like, N-terminal domain | 0.0582 | INHERITED FROM: Shikimate kinase |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.1654 | INHERITED FROM: 6-phosphofructokinase |
lambda repressor-like DNA-binding domains | 0.644 | INHERITED FROM: Ribosylnicotinamide kinase |
Thiamin phosphate synthase | 0.6976 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
Phosphohistidine domain | 0.8459 | INHERITED FROM: Phosphoenolpyruvate--glycerone phosphotransferase || Pyruvate kinase || Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
Cysteine-rich domain | 0.8746 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.9088 | INHERITED FROM: Phosphoenolpyruvate--glycerone phosphotransferase || Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
PH domain-like | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
"Winged helix" DNA-binding domain | 1 | INHERITED FROM: 1-phosphatidylinositol-3-phosphate 5-kinase || CTP-dependent riboflavin kinase |
PUA domain-like | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
EF-hand | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
HAD-like | 1 | INHERITED FROM: Polynucleotide 5'-hydroxyl-kinase |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Ankyrin repeat | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
Nucleotidylyl transferase | 1 | INHERITED FROM: D-glycero-beta-D-manno-heptose-7-phosphate kinase || Riboflavin kinase |
PRTase-like | 1 | INHERITED FROM: Uridine kinase |
Aldolase | 1 | INHERITED FROM: Shikimate kinase |
UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: N-acylmannosamine kinase |
Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
SIS domain | 1 | INHERITED FROM: Glucokinase |
Translation proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Inositol-tetrakisphosphate 1-kinase || Inositol-1,3,4-trisphosphate 5/6-kinase |
NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Shikimate kinase |
Protein kinase-like (PK-like) | 1 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase || Kanamycin kinase || 3-deoxy-D-manno-octulosonic acid kinase || N-acetylmuramate 1-kinase || Hydroxylysine kinase || Phosphatidylinositol-4,5-bisphosphate 3-kinase || 1-phosphatidylinositol 4-kinase || Glycoprotein-mannosyl O(6)-kinase || Homoserine kinase || S-methyl-5-thioribose kinase || Protein-ribulosamine 3-kinase || Thiamine kinase || Phosphatidylinositol 3-kinase || Maltokinase || Choline kinase || Ethanolamine kinase |
SAM/Pointed domain | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
PTS system, Fructose specific IIB subunit-like | 0 | DIRECT |
GrpB-like | 0 | DIRECT |
YgbK-like | 0 | DIRECT |
CoaX-like | 0 | DIRECT |
DhaL-like | 0 | DIRECT |
Fumble-like | 0 | DIRECT |
PTS IIb component | 0 | DIRECT |
ADP-specific Phosphofructokinase/Glucokinase | 0 | DIRECT |
ROK | 0 | DIRECT |
RpiR-like | 0 | DIRECT |
Shikimate kinase (AroK) | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
Adenosine-5'phosphosulfate kinase (APS kinase) | 0 | DIRECT |
CTP-dependent riboflavin kinase-like | 0 | DIRECT |
Choline kinase | 0 | DIRECT |
4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase IspE | 0 | DIRECT |
Phosphofructokinase | 0 | DIRECT |
Type II thymidine kinase | 0 | DIRECT |
Glucokinase | 0 | DIRECT |
Gluconate kinase | 0 | DIRECT |
Glucose permease domain IIB | 0 | DIRECT |
GHMP Kinase, N-terminal domain | 0 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
MarR-like transcriptional regulators | 0 | DIRECT |
Dehydroquinate synthase, DHQS | 0 | DIRECT |
Glycerol kinase | 0 | DIRECT |
DAK1 | 0 | DIRECT |
Trm112p-like | 0 | DIRECT |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
Glycerate kinase I | 0 | DIRECT |
PTS system, Lactose/Cellobiose specific IIB subunit | 0 | DIRECT |
Pyruvate kinase beta-barrel domain | 0 | DIRECT |
Phosphoribulokinase/pantothenate kinase | 0 | DIRECT |
Homoserine kinase | 0 | DIRECT |
DhaM-like | 0 | DIRECT |
Hexokinase | 0 | DIRECT |
Glucose permease-like | 0 | DIRECT |
Thiamin biosynthesis kinases | 0 | DIRECT |
APH phosphotransferases | 0 | DIRECT |
Cytidylyltransferase | 0 | DIRECT |
Pyruvate kinase, C-terminal domain | 0 | DIRECT |
Galactokinase | 0 | DIRECT |
ApbE-like | 0 | DIRECT |
NAD kinase-like | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
Plasmid maintenance system epsilon/zeta, toxin zeta subunit | 0 | DIRECT |
ATP-dependent riboflavin kinase-like | 0 | DIRECT |
Pyruvate kinase | 0 | DIRECT |
Diacylglycerol kinase-like | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
Mevalonate kinase | 0 | DIRECT |
Type II thymidine kinase zinc finger | 0 | DIRECT |
Ribokinase-like | 0 | DIRECT |
Tpt1/KptA | 0 | DIRECT |
Shikimate dehydrogenase-like | 0 | DIRECT |
PfkB-like kinase | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
GckA/TtuD-like | 9.189e-16 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.000000000000003816 | DIRECT |
IIA domain of mannitol-specific and ntr phosphotransferase EII | 0.000000000002103 | DIRECT |
phosphatase domain of polynucleotide kinase | 0.00000000006084 | DIRECT |
BadF/BadG/BcrA/BcrD-like | 0.00000000008425 | DIRECT |
Inositol polyphosphate kinase (IPK) | 0.00000008536 | DIRECT |
FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0000001134 | DIRECT |
EF-hand modules in multidomain proteins | 0.0000006683 | DIRECT |
TENA/THI-4 | 0.00000287 | DIRECT |
HPr-like | 0.000003345 | DIRECT |
Enolpyruvate transferase, EPT | 0.00001334 | DIRECT |
Biotin repressor (BirA) | 0.0000921 | DIRECT |
Ubiquitin-related | 0.0001036 | DIRECT |
UDP-N-acetylglucosamine 2-epimerase | 0.0007681 | DIRECT |
Ras-binding domain, RBD | 0.0009164 | DIRECT |
Biotin holoenzyme synthetase | 0.001438 | INHERITED FROM: Pantothenate kinase |
PX domain | 0.002089 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
PLC-like (P variant) | 0.03328 | INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase |
Class I aldolase | 0.08786 | INHERITED FROM: Shikimate kinase |
Synaptotagmin-like (S variant) | 0.5197 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
Thiamin phosphate synthase | 0.5756 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.7896 | INHERITED FROM: Phosphoenolpyruvate--glycerone phosphotransferase || Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.8398 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Ankyrin repeat | 0.8931 | INHERITED FROM: Diacylglycerol kinase (ATP) |
mono-SIS domain | 0.93 | INHERITED FROM: Glucokinase |
Protein kinases, catalytic subunit | 1 | INHERITED FROM: Glycoprotein-mannosyl O(6)-kinase |
Elongation factors | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Adenylyltransferase | 1 | INHERITED FROM: Riboflavin kinase || Ribosylnicotinamide kinase |
ATP sulfurylase catalytic domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Shikimate kinase |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
RecA protein-like (ATPase-domain) | 1 | INHERITED FROM: Adenosylcobinamide kinase |
Pyruvate phosphate dikinase, C-terminal domain | 1 | INHERITED FROM: Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
G proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Phosphoribosyltransferases (PRTases) | 1 | INHERITED FROM: Uridine kinase |
ATP sulfurylase N-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Nucleotide and nucleoside kinases | 1 | INHERITED FROM: Deoxycytidine kinase || Polynucleotide 5'-hydroxyl-kinase || Dephospho-CoA kinase || Deoxyadenosine kinase || Ribosylnicotinamide kinase || Deoxyguanosine kinase || Thymidine kinase |
N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system | 1 | INHERITED FROM: Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
Pleckstrin-homology domain (PH domain) | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
SAM (sterile alpha motif) domain | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
SCOP term | FDR (all) | Annotation (direct or inherited) |
PTS system, Fructose specific IIB subunit-like | 0 | Direct |
GrpB-like | 0 | Direct |
YgbK-like | 0 | Direct |
CoaX-like | 0 | Direct |
DhaL-like | 0 | Direct |
Fumble-like | 0 | Direct |
PTS IIb component | 0 | Direct |
ADP-specific Phosphofructokinase/Glucokinase | 0 | Direct |
ROK | 0 | Direct |
RpiR-like | 0 | Direct |
Shikimate kinase (AroK) | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
Adenosine-5'phosphosulfate kinase (APS kinase) | 0 | Direct |
CTP-dependent riboflavin kinase-like | 0 | Direct |
Choline kinase | 0 | Direct |
4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase IspE | 0 | Direct |
Phosphofructokinase | 0 | Direct |
Type II thymidine kinase | 0 | Direct |
Glucokinase | 0 | Direct |
Gluconate kinase | 0 | Direct |
Glucose permease domain IIB | 0 | Direct |
GHMP Kinase, N-terminal domain | 0 | Direct |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
MarR-like transcriptional regulators | 0 | Direct |
Dehydroquinate synthase, DHQS | 0 | Direct |
Glycerol kinase | 0 | Direct |
DAK1 | 0 | Direct |
Trm112p-like | 0 | Direct |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
Glycerate kinase I | 0 | Direct |
PTS system, Lactose/Cellobiose specific IIB subunit | 0 | Direct |
Pyruvate kinase beta-barrel domain | 0 | Direct |
Phosphoribulokinase/pantothenate kinase | 0 | Direct |
Homoserine kinase | 0 | Direct |
DhaM-like | 0 | Direct |
Hexokinase | 0 | Direct |
Glucose permease-like | 0 | Direct |
Thiamin biosynthesis kinases | 0 | Direct |
APH phosphotransferases | 0 | Direct |
Cytidylyltransferase | 0 | Direct |
Pyruvate kinase, C-terminal domain | 0 | Direct |
Galactokinase | 0 | Direct |
ApbE-like | 0 | Direct |
NAD kinase-like | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
Plasmid maintenance system epsilon/zeta, toxin zeta subunit | 0 | Direct |
ATP-dependent riboflavin kinase-like | 0 | Direct |
Pyruvate kinase | 0 | Direct |
Diacylglycerol kinase-like | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
Mevalonate kinase | 0 | Direct |
Type II thymidine kinase zinc finger | 0 | Direct |
Ribokinase-like | 0 | Direct |
Tpt1/KptA | 0 | Direct |
Shikimate dehydrogenase-like | 0 | Direct |
PfkB-like kinase | 0 | Direct |
Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
GckA/TtuD-like | 9.189e-16 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.000000000000003816 | Direct |
IIA domain of mannitol-specific and ntr phosphotransferase EII | 0.000000000002103 | Direct |
phosphatase domain of polynucleotide kinase | 0.00000000006084 | Direct |
BadF/BadG/BcrA/BcrD-like | 0.00000000008425 | Direct |
Inositol polyphosphate kinase (IPK) | 0.00000008536 | Direct |
FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0000001134 | Direct |
EF-hand modules in multidomain proteins | 0.0000006683 | Direct |
TENA/THI-4 | 0.00000287 | Direct |
HPr-like | 0.000003345 | Direct |
Enolpyruvate transferase, EPT | 0.00001334 | Direct |
Biotin repressor (BirA) | 0.0000921 | Direct |
Ubiquitin-related | 0.0001036 | Direct |
UDP-N-acetylglucosamine 2-epimerase | 0.0007681 | Direct |
Ras-binding domain, RBD | 0.0009164 | Direct |
Biotin holoenzyme synthetase | 0.001438 | Inherited |
PX domain | 0.002089 | Inherited |
PLC-like (P variant) | 0.03328 | Inherited |
Class I aldolase | 0.08786 | Inherited |
Synaptotagmin-like (S variant) | 0.5197 | Inherited |
Thiamin phosphate synthase | 0.5756 | Inherited |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.7896 | Inherited |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.8398 | Inherited |
Ankyrin repeat | 0.8931 | Inherited |
mono-SIS domain | 0.93 | Inherited |
Protein kinases, catalytic subunit | 1 | Inherited |
Elongation factors | 1 | Inherited |
Adenylyltransferase | 1 | Inherited |
ATP sulfurylase catalytic domain | 1 | Inherited |
Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | Inherited |
RecA protein-like (ATPase-domain) | 1 | Inherited |
Pyruvate phosphate dikinase, C-terminal domain | 1 | Inherited |
G proteins | 1 | Inherited |
Phosphoribosyltransferases (PRTases) | 1 | Inherited |
ATP sulfurylase N-terminal domain | 1 | Inherited |
Nucleotide and nucleoside kinases | 1 | Inherited |
N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system | 1 | Inherited |
Pleckstrin-homology domain (PH domain) | 1 | Inherited |
Phosphoglucomutase, first 3 domains | 1 | Inherited |
SAM (sterile alpha motif) domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Phosphofructokinase | 0 | DIRECT |
Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
PTS system fructose IIA component-like | 0 | DIRECT |
NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
GckA/TtuD-like | 0 | DIRECT |
Ribokinase-like | 0 | DIRECT |
GHMP Kinase, C-terminal domain | 0 | DIRECT |
ApbE-like | 0 | DIRECT |
DAK1/DegV-like | 0 | DIRECT |
YgbK-like | 0 | DIRECT |
DhaL-like | 0 | DIRECT |
Actin-like ATPase domain | 0 | DIRECT |
Glucose permease domain IIB | 0 | DIRECT |
Trm112p-like | 0 | DIRECT |
Riboflavin kinase-like | 0 | DIRECT |
P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
SAICAR synthase-like | 0 | DIRECT |
Glycerate kinase I | 0 | DIRECT |
PK beta-barrel domain-like | 0 | DIRECT |
Ribosomal protein S5 domain 2-like | 0 | DIRECT |
PK C-terminal domain-like | 0 | DIRECT |
PTS system IIB component-like | 0 | DIRECT |
PTS IIb component | 0 | DIRECT |
Dehydroquinate synthase-like | 0.0000000000002226 | DIRECT |
GroEL apical domain-like | 0.000000000001323 | DIRECT |
Duplicated hybrid motif | 0.000000000001433 | DIRECT |
Phoshotransferase/anion transport protein | 0.000000000005396 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0.0000001487 | DIRECT |
Ubiquitin-like | 0.000000313 | DIRECT |
HPr-like | 0.000005324 | DIRECT |
Homeodomain-like | 0.00001121 | DIRECT |
ARM repeat | 0.0000282 | DIRECT |
ADP-ribosylation | 0.0000289 | DIRECT |
C-terminal domain of transcriptional repressors | 0.0001128 | DIRECT |
GroEL-intermediate domain like | 0.0001958 | DIRECT |
EPT/RTPC-like | 0.0005289 | DIRECT |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.002639 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase || Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase |
PX domain | 0.002981 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
Phosphoglycerate mutase-like | 0.008066 | INHERITED FROM: 6-phosphofructo-2-kinase |
FYVE/PHD zinc finger | 0.03811 | INHERITED FROM: 1-phosphatidylinositol-3-phosphate 5-kinase |
Heme oxygenase-like | 0.04695 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
Aminoacid dehydrogenase-like, N-terminal domain | 0.05043 | INHERITED FROM: Shikimate kinase |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.1459 | INHERITED FROM: 6-phosphofructokinase |
lambda repressor-like DNA-binding domains | 0.5912 | INHERITED FROM: Ribosylnicotinamide kinase |
Thiamin phosphate synthase | 0.6412 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
Phosphohistidine domain | 0.7798 | INHERITED FROM: Phosphoenolpyruvate--glycerone phosphotransferase || Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase || Pyruvate kinase |
Cysteine-rich domain | 0.8066 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.839 | INHERITED FROM: Phosphoenolpyruvate--glycerone phosphotransferase || Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
Ankyrin repeat | 0.9517 | INHERITED FROM: Diacylglycerol kinase (ATP) |
UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: N-acylmannosamine kinase |
"Winged helix" DNA-binding domain | 1 | INHERITED FROM: CTP-dependent riboflavin kinase || 1-phosphatidylinositol-3-phosphate 5-kinase |
SAM/Pointed domain | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
EF-hand | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Aldolase | 1 | INHERITED FROM: Shikimate kinase |
Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Inositol-tetrakisphosphate 1-kinase || Inositol-1,3,4-trisphosphate 5/6-kinase |
Protein kinase-like (PK-like) | 1 | INHERITED FROM: 1-phosphatidylinositol 4-kinase || Phosphatidylinositol-4-phosphate 3-kinase || Glycoprotein-mannosyl O(6)-kinase || Maltokinase || Phosphatidylinositol-4,5-bisphosphate 3-kinase || Hydroxylysine kinase || Phosphatidylinositol 3-kinase || S-methyl-5-thioribose kinase || Choline kinase || 3-deoxy-D-manno-octulosonic acid kinase || N-acetylmuramate 1-kinase || Ethanolamine kinase || Protein-ribulosamine 3-kinase || Homoserine kinase || Kanamycin kinase || Thiamine kinase |
NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Shikimate kinase |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
SIS domain | 1 | INHERITED FROM: Glucokinase |
PUA domain-like | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
PH domain-like | 1 | INHERITED FROM: Diacylglycerol kinase (ATP) |
Nucleotidylyl transferase | 1 | INHERITED FROM: Riboflavin kinase || D-glycero-beta-D-manno-heptose-7-phosphate kinase |
PRTase-like | 1 | INHERITED FROM: Uridine kinase |
Translation proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
HAD-like | 1 | INHERITED FROM: Polynucleotide 5'-hydroxyl-kinase |
Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55604,51261 55604 - Glucose permease domain IIB 51261 - Duplicated hybrid motif | 0 | DIRECT |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | DIRECT |
52374,82114 52374 - Nucleotidylyl transferase 82114 - Riboflavin kinase-like | 0 | DIRECT |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
50800,51621 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
56784,52540 56784 - HAD-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53613,48613 53613 - Ribokinase-like 48613 - Heme oxygenase-like | 0 | DIRECT |
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | DIRECT |
55804,52794 55804 - Phoshotransferase/anion transport protein 52794 - PTS system IIB component-like | 0 | DIRECT |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | DIRECT |
53613,52374 53613 - Ribokinase-like 52374 - Nucleotidylyl transferase | 0 | DIRECT |
52540,53271 52540 - P-loop containing nucleoside triphosphate hydrolases 53271 - PRTase-like | 0 | DIRECT |
46689,53697 46689 - Homeodomain-like 53697 - SIS domain | 0 | DIRECT |
51621,52935 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | DIRECT |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 0 | DIRECT |
51621,55804 51621 - Phosphoenolpyruvate/pyruvate domain 55804 - Phoshotransferase/anion transport protein | 0 | DIRECT |
51391,53613 51391 - Thiamin phosphate synthase 53613 - Ribokinase-like | 0 | DIRECT |
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | DIRECT |
52794,52794 52794 - PTS system IIB component-like 52794 - PTS system IIB component-like | 0 | DIRECT |
56112,64268 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | DIRECT |
53756,53067 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53067 - Actin-like ATPase domain | 0 | DIRECT |
46785,82114 46785 - "Winged helix" DNA-binding domain 82114 - Riboflavin kinase-like | 0 | DIRECT |
53062,55594 53062 - PTS system fructose IIA component-like 55594 - HPr-like | 0 | DIRECT |
64268,49562 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
82549,101473 82549 - DAK1/DegV-like 101473 - DhaL-like | 0 | DIRECT |
52794,55804 52794 - PTS system IIB component-like 55804 - Phoshotransferase/anion transport protein | 0 | DIRECT |
50465,52540 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57889,111331 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
54236,56112 54236 - Ubiquitin-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
82185,82185 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
47473,47473 47473 - EF-hand 47473 - EF-hand | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
52540,57716 52540 - P-loop containing nucleoside triphosphate hydrolases 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
52540,88697 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like | 0 | DIRECT |
52540,81301 52540 - P-loop containing nucleoside triphosphate hydrolases 81301 - Nucleotidyltransferase | 0 | DIRECT |
54593,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53784,53784 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | DIRECT |
52935,52009 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | DIRECT |
53613,51391 53613 - Ribokinase-like 51391 - Thiamin phosphate synthase | 0 | DIRECT |
55594,47831 55594 - HPr-like 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.0000006286 | DIRECT |
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors | 0.0001128 | DIRECT |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.0001958 | DIRECT |
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain | 0.000739 | DIRECT |
54236,54236 54236 - Ubiquitin-like 54236 - Ubiquitin-like | 0.001087 | INHERITED FROM: 1-phosphatidylinositol 4-kinase |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0.003616 | INHERITED FROM: Diacylglycerol kinase (ATP) |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0.0109 | INHERITED FROM: Shikimate kinase |
47831,52009 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 52009 - Phosphohistidine domain | 0.839 | INHERITED FROM: Phosphoenolpyruvate--glycerone phosphotransferase || Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Dephospho-CoA kinase || Ribosylnicotinamide kinase |
88697,52374 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Polynucleotide 5'-hydroxyl-kinase |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
52009,51621 52009 - Phosphohistidine domain 51621 - Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55604,51261 55604 - Glucose permease domain IIB 51261 - Duplicated hybrid motif | 0 | Direct |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | Direct |
52374,82114 52374 - Nucleotidylyl transferase 82114 - Riboflavin kinase-like | 0 | Direct |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | Direct |
50800,51621 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
56784,52540 56784 - HAD-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53613,48613 53613 - Ribokinase-like 48613 - Heme oxygenase-like | 0 | Direct |
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | Direct |
55804,52794 55804 - Phoshotransferase/anion transport protein 52794 - PTS system IIB component-like | 0 | Direct |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | Direct |
53613,52374 53613 - Ribokinase-like 52374 - Nucleotidylyl transferase | 0 | Direct |
52540,53271 52540 - P-loop containing nucleoside triphosphate hydrolases 53271 - PRTase-like | 0 | Direct |
46689,53697 46689 - Homeodomain-like 53697 - SIS domain | 0 | Direct |
51621,52935 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | Direct |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 0 | Direct |
51621,55804 51621 - Phosphoenolpyruvate/pyruvate domain 55804 - Phoshotransferase/anion transport protein | 0 | Direct |
51391,53613 51391 - Thiamin phosphate synthase 53613 - Ribokinase-like | 0 | Direct |
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | Direct |
52794,52794 52794 - PTS system IIB component-like 52794 - PTS system IIB component-like | 0 | Direct |
56112,64268 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | Direct |
53756,53067 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53067 - Actin-like ATPase domain | 0 | Direct |
46785,82114 46785 - "Winged helix" DNA-binding domain 82114 - Riboflavin kinase-like | 0 | Direct |
53062,55594 53062 - PTS system fructose IIA component-like 55594 - HPr-like | 0 | Direct |
64268,49562 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
82549,101473 82549 - DAK1/DegV-like 101473 - DhaL-like | 0 | Direct |
52794,55804 52794 - PTS system IIB component-like 55804 - Phoshotransferase/anion transport protein | 0 | Direct |
50465,52540 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57889,111331 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | Direct |
54236,56112 54236 - Ubiquitin-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
82185,82185 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
47473,47473 47473 - EF-hand 47473 - EF-hand | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
52540,57716 52540 - P-loop containing nucleoside triphosphate hydrolases 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
52540,88697 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like | 0 | Direct |
52540,81301 52540 - P-loop containing nucleoside triphosphate hydrolases 81301 - Nucleotidyltransferase | 0 | Direct |
54593,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
53784,53784 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | Direct |
52935,52009 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | Direct |
53613,51391 53613 - Ribokinase-like 51391 - Thiamin phosphate synthase | 0 | Direct |
55594,47831 55594 - HPr-like 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.0000006286 | Direct |
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors | 0.0001128 | Direct |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.0001958 | Direct |
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain | 0.000739 | Direct |
54236,54236 54236 - Ubiquitin-like 54236 - Ubiquitin-like | 0.001087 | Inherited |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0.003616 | Inherited |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0.0109 | Inherited |
47831,52009 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 52009 - Phosphohistidine domain | 0.839 | Inherited |
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
88697,52374 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 1 | Inherited |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | Inherited |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 1 | Inherited |
52009,51621 52009 - Phosphohistidine domain 51621 - Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50447,50465,52540 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55681,50037,53067 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | DIRECT |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
57889,57889,111331 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
50800,51621,52935 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | DIRECT |
52540,88697,52374 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | DIRECT |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | DIRECT |
53062,55594,47831 53062 - PTS system fructose IIA component-like 55594 - HPr-like 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0 | DIRECT |
50037,53067,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | DIRECT |
48371,56112,64268 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | DIRECT |
52009,51621,55804 52009 - Phosphohistidine domain 51621 - Phosphoenolpyruvate/pyruvate domain 55804 - Phoshotransferase/anion transport protein | 0 | DIRECT |
51621,52935,52009 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | DIRECT |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
50729,57889,57889 50729 - PH domain-like 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
54593,53784,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | DIRECT |
47473,47473,57889 47473 - EF-hand 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,64268,49562 56112 - Protein kinase-like (PK-like) 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
47473,57889,57889 47473 - EF-hand 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
54236,54236,56112 54236 - Ubiquitin-like 54236 - Ubiquitin-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.00000000002582 | DIRECT |
55594,47831,52009 55594 - HPr-like 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 52009 - Phosphohistidine domain | 0.0000006286 | DIRECT |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
47831,52009,51621 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 52009 - Phosphohistidine domain 51621 - Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50447,50465,52540 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55681,50037,53067 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | Direct |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
57889,57889,111331 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | Direct |
50800,51621,52935 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | Direct |
52540,88697,52374 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | Direct |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | Direct |
53062,55594,47831 53062 - PTS system fructose IIA component-like 55594 - HPr-like 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0 | Direct |
50037,53067,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | Direct |
48371,56112,64268 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | Direct |
52009,51621,55804 52009 - Phosphohistidine domain 51621 - Phosphoenolpyruvate/pyruvate domain 55804 - Phoshotransferase/anion transport protein | 0 | Direct |
51621,52935,52009 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | Direct |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
50729,57889,57889 50729 - PH domain-like 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
54593,53784,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | Direct |
47473,47473,57889 47473 - EF-hand 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,64268,49562 56112 - Protein kinase-like (PK-like) 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
47473,57889,57889 47473 - EF-hand 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
54236,54236,56112 54236 - Ubiquitin-like 54236 - Ubiquitin-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.00000000002582 | Direct |
55594,47831,52009 55594 - HPr-like 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 52009 - Phosphohistidine domain | 0.0000006286 | Direct |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | Inherited |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | Inherited |
47831,52009,51621 47831 - Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 52009 - Phosphohistidine domain 51621 - Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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