Enzyme Commission (EC): Protein-histidine kinases

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: root [root] <7>

+ + 2: Transferases [2] <10> (445|680) (444|535|275)

+ 1: Transferring phosphorus-containing groups [2.7] <15> (255|337) (254|318|190)

0: Protein-histidine kinases [2.7.13] <3> (12|18) (12|27|23)

- 1: Histidine kinase [2.7.13.3] (0|0) (0|0|0)

- 1: Protein-histidine pros-kinase [2.7.13.1] (0|0) (0|0|0)

- 1: Protein-histidine tele-kinase [2.7.13.2] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
HAMP domain-like	0	Direct
CheW-like	0	Direct
CheY-like	0	Direct
Homodimeric domain of signal transducing histidine kinase	0	Direct
Sporulation response regulatory protein Spo0B	0	Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
Histidine-containing phosphotransfer domain, HPT domain	0	Direct
CheY-binding domain of CheA	0	Direct
Sensory domain-like	0	Direct
GAF domain-like	0	Direct
PYP-like sensor domain (PAS domain)	0	Direct
Thioredoxin-like	0.0004443	Direct

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
KaiB-like	0	Direct
Receiver domain of the ethylene receptor	0	Direct
Sensory domain of two-component sensor kinase	0	Direct
Chemotaxis protein CheA P1 domain	0	Direct
GAF domain	0	Direct
Sporulation response regulatory protein Spo0B	0	Direct
HAMP domain	0	Direct
Homodimeric domain of signal transducing histidine kinase	0	Direct
Heme-binding PAS domain	0	Direct
CheW-like	0	Direct
Histidine kinase	0	Direct
CheY-related	0	Direct
Flavin-binding PAS domain	0	Direct
RcsC linker domain-like	0	Direct
CheY-binding domain of CheA	0	Direct
LuxQ-periplasmic domain-like	0	Direct
BphP N-terminal domain-like	0.00000000001697	Direct
Phytochrome-specific domain	0.00000000001697	Direct

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Homodimeric domain of signal transducing histidine kinase	0	Direct
PYP-like sensor domain (PAS domain)	0	Direct
GAF domain-like	0	Direct
Sporulation response regulatory protein Spo0B	0	Direct
Sensory domain-like	0	Direct
CheY-like	0	Direct
CheY-binding domain of CheA	0	Direct
Histidine-containing phosphotransfer domain, HPT domain	0	Direct
HAMP domain-like	0	Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
CheW-like	0	Direct
Thioredoxin-like	0.0003627	Direct

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
103190,47384 103190 - Sensory domain-like 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
158472,55785 158472 - HAMP domain-like 55785 - PYP-like sensor domain (PAS domain)	0	Direct
52172,55785 52172 - CheY-like 55785 - PYP-like sensor domain (PAS domain)	0	Direct
55781,47384 55781 - GAF domain-like 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
158472,47384 158472 - HAMP domain-like 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
55890,55874 55890 - Sporulation response regulatory protein Spo0B 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
55874,52172 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 52172 - CheY-like	0	Direct
53850,55785 53850 - Periplasmic binding protein-like II 55785 - PYP-like sensor domain (PAS domain)	0	Direct
55781,55874 55781 - GAF domain-like 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
52172,47226 52172 - CheY-like 47226 - Histidine-containing phosphotransfer domain, HPT domain	0	Direct
47226,55052 47226 - Histidine-containing phosphotransfer domain, HPT domain 55052 - CheY-binding domain of CheA	0	Direct
52540,52402 52540 - P-loop containing nucleoside triphosphate hydrolases 52402 - Adenine nucleotide alpha hydrolases-like	0	Direct
52833,47384 52833 - Thioredoxin-like 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
55785,55890 55785 - PYP-like sensor domain (PAS domain) 55890 - Sporulation response regulatory protein Spo0B	0	Direct
103190,158472 103190 - Sensory domain-like 158472 - HAMP domain-like	0	Direct
55785,47384 55785 - PYP-like sensor domain (PAS domain) 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
55874,50341 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 50341 - CheW-like	0	Direct
55052,47384 55052 - CheY-binding domain of CheA 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
103190,55785 103190 - Sensory domain-like 55785 - PYP-like sensor domain (PAS domain)	0	Direct
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0	Direct
47384,55874 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
52172,52172 52172 - CheY-like 52172 - CheY-like	0	Direct
55785,55781 55785 - PYP-like sensor domain (PAS domain) 55781 - GAF domain-like	0.000000000000005248	Direct
55781,55781 55781 - GAF domain-like 55781 - GAF domain-like	0.0000000000004186	Direct
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0.0000000005418	Direct
55781,55785 55781 - GAF domain-like 55785 - PYP-like sensor domain (PAS domain)	0.00000007872	Direct
56112,52540 56112 - Protein kinase-like (PK-like) 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0000003825	Direct

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55052,47384,55874 55052 - CheY-binding domain of CheA 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
53850,53850,55785 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II 55785 - PYP-like sensor domain (PAS domain)	0	Direct
55785,55890,55874 55785 - PYP-like sensor domain (PAS domain) 55890 - Sporulation response regulatory protein Spo0B 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
103190,55785,55890 103190 - Sensory domain-like 55785 - PYP-like sensor domain (PAS domain) 55890 - Sporulation response regulatory protein Spo0B	0	Direct
55785,47384,55874 55785 - PYP-like sensor domain (PAS domain) 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
47384,55874,52172 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 52172 - CheY-like	0	Direct
158472,47384,55874 158472 - HAMP domain-like 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
53850,55785,47384 53850 - Periplasmic binding protein-like II 55785 - PYP-like sensor domain (PAS domain) 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
55874,52172,47226 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 52172 - CheY-like 47226 - Histidine-containing phosphotransfer domain, HPT domain	0	Direct
47384,55874,50341 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 50341 - CheW-like	0	Direct
52172,55785,47384 52172 - CheY-like 55785 - PYP-like sensor domain (PAS domain) 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
158472,55785,47384 158472 - HAMP domain-like 55785 - PYP-like sensor domain (PAS domain) 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
47226,55052,47384 47226 - Histidine-containing phosphotransfer domain, HPT domain 55052 - CheY-binding domain of CheA 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
103190,47384,55874 103190 - Sensory domain-like 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
55781,55781,47384 55781 - GAF domain-like 55781 - GAF domain-like 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
103190,158472,55785 103190 - Sensory domain-like 158472 - HAMP domain-like 55785 - PYP-like sensor domain (PAS domain)	0	Direct
55785,55785,47384 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) 47384 - Homodimeric domain of signal transducing histidine kinase	0	Direct
52833,47384,55874 52833 - Thioredoxin-like 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
55781,47384,55874 55781 - GAF domain-like 47384 - Homodimeric domain of signal transducing histidine kinase 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	Direct
55874,52172,52172 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 52172 - CheY-like 52172 - CheY-like	0	Direct
55874,52172,55785 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 52172 - CheY-like 55785 - PYP-like sensor domain (PAS domain)	0	Direct
55785,55781,55781 55785 - PYP-like sensor domain (PAS domain) 55781 - GAF domain-like 55781 - GAF domain-like	0.00000000002046	Direct
55785,55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.000000001273	Direct

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Enzyme Commission (EC): Protein-histidine kinases

Superfamily

Family

Supra-domain (including individual superfamily)