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Enzyme Commission (EC): Nucleotidyltransferases
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
Nucleic acid-binding proteins | 0 | DIRECT |
Retrovirus capsid dimerization domain-like | 0 | DIRECT |
Zinc finger domain of DNA polymerase-alpha | 0 | DIRECT |
YrdC/RibB | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
PIN domain-like | 0 | DIRECT |
PAP/OAS1 substrate-binding domain | 0 | DIRECT |
DNA polymerase III chi subunit | 0 | DIRECT |
5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
Positive stranded ssRNA viruses | 0 | DIRECT |
Replicase NSP9 | 0 | DIRECT |
EndoU-like | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Retroviral matrix proteins | 0 | DIRECT |
Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
post-AAA+ oligomerization domain-like | 0 | DIRECT |
ACT-like | 0 | DIRECT |
Ribonuclease H-like | 0 | DIRECT |
Flavivirus capsid protein C | 0 | DIRECT |
RNA polymerase subunits | 0 | DIRECT |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
Viral leader polypeptide zinc finger | 0 | DIRECT |
Trypsin-like serine proteases | 0 | DIRECT |
PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
Nucleotidylyl transferase | 0 | DIRECT |
Molybdenum cofactor biosynthesis proteins | 0 | DIRECT |
Nucleotide-diphospho-sugar transferases | 0 | DIRECT |
Acid proteases | 0 | DIRECT |
RNA polymerase subunit RPB10 | 0 | DIRECT |
RPB5-like RNA polymerase subunit | 0 | DIRECT |
IpsF-like | 0 | DIRECT |
PsbU/PolX domain-like | 0 | DIRECT |
Nucleotidyltransferase | 0 | DIRECT |
Fic-like | 0 | DIRECT |
Coronavirus NSP10-like | 0 | DIRECT |
PHP domain-like | 0 | DIRECT |
DNA-binding domain of retroviral integrase | 0 | DIRECT |
Coronavirus NSP8-like | 0 | DIRECT |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | DIRECT |
Nucleotidyltransferase substrate binding subunit/domain | 0 | DIRECT |
Insert subdomain of RNA polymerase alpha subunit | 0 | DIRECT |
HD-domain/PDEase-like | 0 | DIRECT |
Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
Ribosomal protein S5 domain 2-like | 0 | DIRECT |
Retrovirus zinc finger-like domains | 0 | DIRECT |
N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
Coronavirus NSP7-like | 0 | DIRECT |
AF1531-like | 0 | DIRECT |
Poly(A) polymerase catalytic subunit-like | 0 | DIRECT |
YojJ-like | 0 | DIRECT |
DNA/RNA polymerases | 0 | DIRECT |
C-terminal domain of RNA polymerase alpha subunit | 0 | DIRECT |
Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
Trimeric LpxA-like enzymes | 0 | DIRECT |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | 0 | DIRECT |
Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
RPB6/omega subunit-like | 0 | DIRECT |
Poly A polymerase C-terminal region-like | 0 | DIRECT |
Macro domain-like | 5.111e-16 | DIRECT |
NSP3A-like | 5.111e-16 | DIRECT |
Hedgehog/intein (Hint) domain | 0.00000000002264 | DIRECT |
HIT-like | 0.000000001925 | DIRECT |
Nucleotide cyclase | 0.00000004469 | DIRECT |
Homing endonucleases | 0.0000003179 | DIRECT |
MoeA N-terminal region -like | 0.00001726 | DIRECT |
MoeA C-terminal domain-like | 0.00001726 | DIRECT |
SARS Nsp1-like | 0.00004384 | DIRECT |
Translation proteins | 0.0001085 | DIRECT |
E set domains | 0.0001353 | DIRECT |
CYTH-like phosphatases | 0.002073 | INHERITED FROM: mRNA guanylyltransferase |
beta-beta-alpha zinc fingers | 0.003957 | INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase |
RNA-binding domain, RBD | 0.04617 | INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase |
Zinc beta-ribbon | 0.04805 | INHERITED FROM: DNA-directed RNA polymerase |
TPR-like | 0.06452 | INHERITED FROM: Protein adenylyltransferase |
Ribonuclease Rh-like | 0.07425 | INHERITED FROM: RNA-directed RNA polymerase |
Globin-like | 0.09337 | INHERITED FROM: Diguanylate cyclase |
Sec63 N-terminal domain-like | 0.2582 | INHERITED FROM: DNA-directed DNA polymerase |
DNase I-like | 0.6318 | INHERITED FROM: RNA-directed DNA polymerase |
SGNH hydrolase | 0.9247 | INHERITED FROM: N-acylneuraminate cytidylyltransferase |
Ribokinase-like | 1 | INHERITED FROM: D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase |
Cysteine proteinases | 1 | INHERITED FROM: RNA-directed RNA polymerase |
(Phosphotyrosine protein) phosphatases II | 1 | INHERITED FROM: mRNA guanylyltransferase |
PUA domain-like | 1 | INHERITED FROM: Sulfate adenylyltransferase |
RuvA domain 2-like | 1 | INHERITED FROM: Diadenylate cyclase |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: mRNA guanylyltransferase || RNA-directed RNA polymerase |
Nudix | 1 | INHERITED FROM: ADP-D-ribose pyrophosphorylase |
Riboflavin kinase-like | 1 | INHERITED FROM: FAD synthase |
HAD-like | 1 | INHERITED FROM: N-acylneuraminate cytidylyltransferase |
Clavaminate synthase-like | 1 | INHERITED FROM: RNA-directed RNA polymerase |
Adenine nucleotide alpha hydrolases-like | 1 | INHERITED FROM: FAD synthase || Sulfate adenylyltransferase |
lambda repressor-like DNA-binding domains | 1 | INHERITED FROM: Nicotinamide-nucleotide adenylyltransferase |
BRCT domain | 1 | INHERITED FROM: DNA nucleotidylexotransferase |
P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Sulfate adenylyltransferase || Polynucleotide adenylyltransferase || Adenosylcobinamide-phosphate guanylyltransferase || RNA-directed RNA polymerase |
RmlC-like cupins | 1 | INHERITED FROM: Mannose-1-phosphate guanylyltransferase |
DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: mRNA guanylyltransferase |
dUTPase-like | 1 | INHERITED FROM: RNA-directed DNA polymerase || DNA-directed DNA polymerase |
Protein kinase-like (PK-like) | 1 | INHERITED FROM: Protein adenylyltransferase |
PYP-like sensor domain (PAS domain) | 1 | INHERITED FROM: Diguanylate cyclase |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
Nucleic acid-binding proteins | 0 | Direct |
Retrovirus capsid dimerization domain-like | 0 | Direct |
Zinc finger domain of DNA polymerase-alpha | 0 | Direct |
YrdC/RibB | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
PIN domain-like | 0 | Direct |
PAP/OAS1 substrate-binding domain | 0 | Direct |
DNA polymerase III chi subunit | 0 | Direct |
5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
Positive stranded ssRNA viruses | 0 | Direct |
Replicase NSP9 | 0 | Direct |
EndoU-like | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Retroviral matrix proteins | 0 | Direct |
Soluble domain of poliovirus core protein 3a | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
DNA polymerase beta, N-terminal domain-like | 0 | Direct |
post-AAA+ oligomerization domain-like | 0 | Direct |
ACT-like | 0 | Direct |
Ribonuclease H-like | 0 | Direct |
Flavivirus capsid protein C | 0 | Direct |
RNA polymerase subunits | 0 | Direct |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
Viral leader polypeptide zinc finger | 0 | Direct |
Trypsin-like serine proteases | 0 | Direct |
PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
Nucleotidylyl transferase | 0 | Direct |
Molybdenum cofactor biosynthesis proteins | 0 | Direct |
Nucleotide-diphospho-sugar transferases | 0 | Direct |
Acid proteases | 0 | Direct |
RNA polymerase subunit RPB10 | 0 | Direct |
RPB5-like RNA polymerase subunit | 0 | Direct |
IpsF-like | 0 | Direct |
PsbU/PolX domain-like | 0 | Direct |
Nucleotidyltransferase | 0 | Direct |
Fic-like | 0 | Direct |
Coronavirus NSP10-like | 0 | Direct |
PHP domain-like | 0 | Direct |
DNA-binding domain of retroviral integrase | 0 | Direct |
Coronavirus NSP8-like | 0 | Direct |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | Direct |
Nucleotidyltransferase substrate binding subunit/domain | 0 | Direct |
Insert subdomain of RNA polymerase alpha subunit | 0 | Direct |
HD-domain/PDEase-like | 0 | Direct |
Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
Ribosomal protein S5 domain 2-like | 0 | Direct |
Retrovirus zinc finger-like domains | 0 | Direct |
N-terminal Zn binding domain of HIV integrase | 0 | Direct |
Viral glycoprotein, central and dimerisation domains | 0 | Direct |
Coronavirus NSP7-like | 0 | Direct |
AF1531-like | 0 | Direct |
Poly(A) polymerase catalytic subunit-like | 0 | Direct |
YojJ-like | 0 | Direct |
DNA/RNA polymerases | 0 | Direct |
C-terminal domain of RNA polymerase alpha subunit | 0 | Direct |
Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
Trimeric LpxA-like enzymes | 0 | Direct |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | 0 | Direct |
Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
RPB6/omega subunit-like | 0 | Direct |
Poly A polymerase C-terminal region-like | 0 | Direct |
Macro domain-like | 5.111e-16 | Direct |
NSP3A-like | 5.111e-16 | Direct |
Hedgehog/intein (Hint) domain | 0.00000000002264 | Direct |
HIT-like | 0.000000001925 | Direct |
Nucleotide cyclase | 0.00000004469 | Direct |
Homing endonucleases | 0.0000003179 | Direct |
MoeA N-terminal region -like | 0.00001726 | Direct |
MoeA C-terminal domain-like | 0.00001726 | Direct |
SARS Nsp1-like | 0.00004384 | Direct |
Translation proteins | 0.0001085 | Direct |
E set domains | 0.0001353 | Direct |
CYTH-like phosphatases | 0.002073 | Inherited |
beta-beta-alpha zinc fingers | 0.003957 | Inherited |
RNA-binding domain, RBD | 0.04617 | Inherited |
Zinc beta-ribbon | 0.04805 | Inherited |
TPR-like | 0.06452 | Inherited |
Ribonuclease Rh-like | 0.07425 | Inherited |
Globin-like | 0.09337 | Inherited |
Sec63 N-terminal domain-like | 0.2582 | Inherited |
DNase I-like | 0.6318 | Inherited |
SGNH hydrolase | 0.9247 | Inherited |
Ribokinase-like | 1 | Inherited |
Cysteine proteinases | 1 | Inherited |
(Phosphotyrosine protein) phosphatases II | 1 | Inherited |
PUA domain-like | 1 | Inherited |
RuvA domain 2-like | 1 | Inherited |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
Nudix | 1 | Inherited |
Riboflavin kinase-like | 1 | Inherited |
HAD-like | 1 | Inherited |
Clavaminate synthase-like | 1 | Inherited |
Adenine nucleotide alpha hydrolases-like | 1 | Inherited |
lambda repressor-like DNA-binding domains | 1 | Inherited |
BRCT domain | 1 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
RmlC-like cupins | 1 | Inherited |
DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
dUTPase-like | 1 | Inherited |
Protein kinase-like (PK-like) | 1 | Inherited |
PYP-like sensor domain (PAS domain) | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Archaeal tRNA CCA-adding enzyme | 0 | DIRECT |
HTLV-II matrix protein | 0 | DIRECT |
RNA polymerase omega subunit | 0 | DIRECT |
Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
DNA polymerase beta-like, second domain | 0 | DIRECT |
Retrovirus zinc finger-like domains | 0 | DIRECT |
T7 RNA polymerase | 0 | DIRECT |
Poly(A) polymerase, PAP, N-terminal domain | 0 | DIRECT |
Viral proteases | 0 | DIRECT |
AF1531-like | 0 | DIRECT |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | 0 | DIRECT |
Poly(A) polymerase, PAP, C-terminal domain | 0 | DIRECT |
DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
Viral cysteine protease of trypsin fold | 0 | DIRECT |
Elongation factors | 0 | DIRECT |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | DIRECT |
Ribonuclease PH domain 1-like | 0 | DIRECT |
Archaeal tRNA CCA-adding enzyme substrate-binding domain | 0 | DIRECT |
Archaeal tRNA CCA-adding enzyme catalytic domain | 0 | DIRECT |
DNA polymerase I | 0 | DIRECT |
PHP domain | 0 | DIRECT |
5' to 3' exonuclease catalytic domain | 0 | DIRECT |
Adenylyltransferase | 0 | DIRECT |
DNA polymerase III chi subunit | 0 | DIRECT |
RPB6 | 0 | DIRECT |
FMDV leader protease | 0 | DIRECT |
Insert subdomain of RNA polymerase alpha subunit | 0 | DIRECT |
RNA helicase | 0 | DIRECT |
RNA-polymerase beta-prime | 0 | DIRECT |
PAPS reductase-like | 0 | DIRECT |
DNA polymerase beta-like | 0 | DIRECT |
GlmU C-terminal domain-like | 0 | DIRECT |
ATP sulfurylase catalytic domain | 0 | DIRECT |
Nsp15 N-terminal domain-like | 0 | DIRECT |
Retrovirus capsid protein C-terminal domain | 0 | DIRECT |
Cold shock DNA-binding domain-like | 0 | DIRECT |
Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
Coronavirus NSP7-like | 0 | DIRECT |
RNA polymerase subunit RPB10 | 0 | DIRECT |
Molybdenum cofactor biosynthesis protein MobA | 0 | DIRECT |
GGDEF domain | 0 | DIRECT |
Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | DIRECT |
Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
Molybdenum cofactor biosynthesis protein MoeB | 0 | DIRECT |
RBP11/RpoL | 0 | DIRECT |
Class II viral fusion proteins C-terminal domain | 0 | DIRECT |
Flavivirus capsid protein C | 0 | DIRECT |
MogA-like | 0 | DIRECT |
mRNA capping enzyme | 0 | DIRECT |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
Immunodeficiency virus matrix proteins | 0 | DIRECT |
Caliciviridae-like VP | 0 | DIRECT |
Cytidylytransferase | 0 | DIRECT |
Nsp15 C-terminal domain-like | 0 | DIRECT |
Coronavirus NSP10-like | 0 | DIRECT |
YojJ-like | 0 | DIRECT |
ATP sulfurylase N-terminal domain | 0 | DIRECT |
2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
mannose-1-phosphate guanylyl transferase | 0 | DIRECT |
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
Zinc finger domain of DNA polymerase-alpha | 0 | DIRECT |
Fic-like | 0 | DIRECT |
GAG polyprotein M-domain | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
RPB5 | 0 | DIRECT |
Retroviral integrase, catalytic domain | 0 | DIRECT |
MMLV matrix protein-like | 0 | DIRECT |
Poly(A) polymerase, PAP, middle domain | 0 | DIRECT |
Coronavirus NSP8-like | 0 | DIRECT |
DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
Cytidylyltransferase | 0 | DIRECT |
glucose-1-phosphate thymidylyltransferase | 0 | DIRECT |
Poxvirus poly(A) polymerase catalytic subunit-like | 0 | DIRECT |
Macro domain | 0 | DIRECT |
IpsF-like | 0 | DIRECT |
Poly A polymerase C-terminal region-like | 0 | DIRECT |
Hexose-1-phosphate uridylyltransferase | 0 | DIRECT |
C-terminal domain of RNA polymerase alpha subunit | 0 | DIRECT |
Reverse transcriptase | 0 | DIRECT |
RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
GlnE-like domain | 0 | DIRECT |
YrdC-like | 0 | DIRECT |
Glutamine synthase adenylyltransferase GlnE, domain 2 | 0 | DIRECT |
DNA-binding domain of retroviral integrase | 0 | DIRECT |
Retroviral protease (retropepsin) | 0 | DIRECT |
RNA polymerase alpha subunit dimerisation domain | 0 | DIRECT |
MM2497-like | 0 | DIRECT |
mRNA cap methylase | 0 | DIRECT |
Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
RNA-polymerase beta | 0 | DIRECT |
RNA-dependent RNA-polymerase | 0 | DIRECT |
Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
Viral leader polypeptide zinc finger | 0 | DIRECT |
DnaQ-like 3'-5' exonuclease | 0 | DIRECT |
ATP sulfurylase C-terminal domain | 0 | DIRECT |
Replicase NSP9 | 0 | DIRECT |
Poly A polymerase head domain-like | 0 | DIRECT |
UDP-glucose pyrophosphorylase | 0 | DIRECT |
NSP3A-like | 1.855e-16 | DIRECT |
Ribonuclease H | 0.0000000000000379 | DIRECT |
G proteins | 0.000000000001547 | DIRECT |
Mason-Pfizer monkey virus matrix protein | 0.00000002172 | DIRECT |
Probable phosphatase YrbI | 0.00000002172 | DIRECT |
Intein (protein splicing domain) | 0.000000153 | DIRECT |
Ribokinase-like | 0.0000004709 | DIRECT |
MoeA C-terminal domain-like | 0.000006999 | DIRECT |
MoeA N-terminal region -like | 0.00001068 | DIRECT |
MoeA central domain-like | 0.00001068 | DIRECT |
SARS Nsp1-like | 0.00002985 | DIRECT |
AlkB-like | 0.0001905 | DIRECT |
DNase I-like | 0.01878 | INHERITED FROM: RNA-directed DNA polymerase |
mRNA cap (Guanine N-7) methyltransferase | 0.02116 | INHERITED FROM: mRNA guanylyltransferase |
Canonical RBD | 0.02409 | INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase |
Achaeal helicase C-terminal domain | 0.03692 | INHERITED FROM: DNA-directed DNA polymerase |
Ribonuclease Rh-like | 0.05663 | INHERITED FROM: RNA-directed RNA polymerase |
Globins | 0.1626 | INHERITED FROM: Diguanylate cyclase |
MutT-like | 0.3638 | INHERITED FROM: ADP-D-ribose pyrophosphorylase |
ATP-dependent riboflavin kinase-like | 0.9032 | INHERITED FROM: FAD synthase |
Dual specificity phosphatase-like | 1 | INHERITED FROM: mRNA guanylyltransferase |
Adenosine-5'phosphosulfate kinase (APS kinase) | 1 | INHERITED FROM: Sulfate adenylyltransferase |
DNA ligase/mRNA capping enzyme postcatalytic domain | 1 | INHERITED FROM: mRNA guanylyltransferase |
RecA protein-like (ATPase-domain) | 1 | INHERITED FROM: Adenosylcobinamide-phosphate guanylyltransferase |
dUTPase-like | 1 | INHERITED FROM: RNA-directed DNA polymerase || DNA-directed DNA polymerase |
Extended AAA-ATPase domain | 1 | INHERITED FROM: DNA-directed DNA polymerase |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Archaeal tRNA CCA-adding enzyme | 0 | Direct |
HTLV-II matrix protein | 0 | Direct |
RNA polymerase omega subunit | 0 | Direct |
Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
DNA polymerase beta-like, second domain | 0 | Direct |
Retrovirus zinc finger-like domains | 0 | Direct |
T7 RNA polymerase | 0 | Direct |
Poly(A) polymerase, PAP, N-terminal domain | 0 | Direct |
Viral proteases | 0 | Direct |
AF1531-like | 0 | Direct |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | 0 | Direct |
Poly(A) polymerase, PAP, C-terminal domain | 0 | Direct |
DNA polymerase beta, N-terminal domain-like | 0 | Direct |
Viral cysteine protease of trypsin fold | 0 | Direct |
Elongation factors | 0 | Direct |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | Direct |
Ribonuclease PH domain 1-like | 0 | Direct |
Archaeal tRNA CCA-adding enzyme substrate-binding domain | 0 | Direct |
Archaeal tRNA CCA-adding enzyme catalytic domain | 0 | Direct |
DNA polymerase I | 0 | Direct |
PHP domain | 0 | Direct |
5' to 3' exonuclease catalytic domain | 0 | Direct |
Adenylyltransferase | 0 | Direct |
DNA polymerase III chi subunit | 0 | Direct |
RPB6 | 0 | Direct |
FMDV leader protease | 0 | Direct |
Insert subdomain of RNA polymerase alpha subunit | 0 | Direct |
RNA helicase | 0 | Direct |
RNA-polymerase beta-prime | 0 | Direct |
PAPS reductase-like | 0 | Direct |
DNA polymerase beta-like | 0 | Direct |
GlmU C-terminal domain-like | 0 | Direct |
ATP sulfurylase catalytic domain | 0 | Direct |
Nsp15 N-terminal domain-like | 0 | Direct |
Retrovirus capsid protein C-terminal domain | 0 | Direct |
Cold shock DNA-binding domain-like | 0 | Direct |
Viral glycoprotein, central and dimerisation domains | 0 | Direct |
Coronavirus NSP7-like | 0 | Direct |
RNA polymerase subunit RPB10 | 0 | Direct |
Molybdenum cofactor biosynthesis protein MobA | 0 | Direct |
GGDEF domain | 0 | Direct |
Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | Direct |
Soluble domain of poliovirus core protein 3a | 0 | Direct |
5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
Molybdenum cofactor biosynthesis protein MoeB | 0 | Direct |
RBP11/RpoL | 0 | Direct |
Class II viral fusion proteins C-terminal domain | 0 | Direct |
Flavivirus capsid protein C | 0 | Direct |
MogA-like | 0 | Direct |
mRNA capping enzyme | 0 | Direct |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
Immunodeficiency virus matrix proteins | 0 | Direct |
Caliciviridae-like VP | 0 | Direct |
Cytidylytransferase | 0 | Direct |
Nsp15 C-terminal domain-like | 0 | Direct |
Coronavirus NSP10-like | 0 | Direct |
YojJ-like | 0 | Direct |
ATP sulfurylase N-terminal domain | 0 | Direct |
2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
mannose-1-phosphate guanylyl transferase | 0 | Direct |
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
Zinc finger domain of DNA polymerase-alpha | 0 | Direct |
Fic-like | 0 | Direct |
GAG polyprotein M-domain | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
RPB5 | 0 | Direct |
Retroviral integrase, catalytic domain | 0 | Direct |
MMLV matrix protein-like | 0 | Direct |
Poly(A) polymerase, PAP, middle domain | 0 | Direct |
Coronavirus NSP8-like | 0 | Direct |
DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
N-terminal Zn binding domain of HIV integrase | 0 | Direct |
Cytidylyltransferase | 0 | Direct |
glucose-1-phosphate thymidylyltransferase | 0 | Direct |
Poxvirus poly(A) polymerase catalytic subunit-like | 0 | Direct |
Macro domain | 0 | Direct |
IpsF-like | 0 | Direct |
Poly A polymerase C-terminal region-like | 0 | Direct |
Hexose-1-phosphate uridylyltransferase | 0 | Direct |
C-terminal domain of RNA polymerase alpha subunit | 0 | Direct |
Reverse transcriptase | 0 | Direct |
RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
GlnE-like domain | 0 | Direct |
YrdC-like | 0 | Direct |
Glutamine synthase adenylyltransferase GlnE, domain 2 | 0 | Direct |
DNA-binding domain of retroviral integrase | 0 | Direct |
Retroviral protease (retropepsin) | 0 | Direct |
RNA polymerase alpha subunit dimerisation domain | 0 | Direct |
MM2497-like | 0 | Direct |
mRNA cap methylase | 0 | Direct |
Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
RNA-polymerase beta | 0 | Direct |
RNA-dependent RNA-polymerase | 0 | Direct |
Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
Viral leader polypeptide zinc finger | 0 | Direct |
DnaQ-like 3'-5' exonuclease | 0 | Direct |
ATP sulfurylase C-terminal domain | 0 | Direct |
Replicase NSP9 | 0 | Direct |
Poly A polymerase head domain-like | 0 | Direct |
UDP-glucose pyrophosphorylase | 0 | Direct |
NSP3A-like | 1.855e-16 | Direct |
Ribonuclease H | 0.0000000000000379 | Direct |
G proteins | 0.000000000001547 | Direct |
Mason-Pfizer monkey virus matrix protein | 0.00000002172 | Direct |
Probable phosphatase YrbI | 0.00000002172 | Direct |
Intein (protein splicing domain) | 0.000000153 | Direct |
Ribokinase-like | 0.0000004709 | Direct |
MoeA C-terminal domain-like | 0.000006999 | Direct |
MoeA N-terminal region -like | 0.00001068 | Direct |
MoeA central domain-like | 0.00001068 | Direct |
SARS Nsp1-like | 0.00002985 | Direct |
AlkB-like | 0.0001905 | Direct |
DNase I-like | 0.01878 | Inherited |
mRNA cap (Guanine N-7) methyltransferase | 0.02116 | Inherited |
Canonical RBD | 0.02409 | Inherited |
Achaeal helicase C-terminal domain | 0.03692 | Inherited |
Ribonuclease Rh-like | 0.05663 | Inherited |
Globins | 0.1626 | Inherited |
MutT-like | 0.3638 | Inherited |
ATP-dependent riboflavin kinase-like | 0.9032 | Inherited |
Dual specificity phosphatase-like | 1 | Inherited |
Adenosine-5'phosphosulfate kinase (APS kinase) | 1 | Inherited |
DNA ligase/mRNA capping enzyme postcatalytic domain | 1 | Inherited |
RecA protein-like (ATPase-domain) | 1 | Inherited |
dUTPase-like | 1 | Inherited |
Extended AAA-ATPase domain | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
Retrovirus capsid dimerization domain-like | 0 | DIRECT |
Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
Ribonuclease H-like | 0 | DIRECT |
DNA polymerase III chi subunit | 0 | DIRECT |
Flavivirus capsid protein C | 0 | DIRECT |
AF1531-like | 0 | DIRECT |
YrdC/RibB | 0 | DIRECT |
Fic-like | 0 | DIRECT |
PAP/OAS1 substrate-binding domain | 0 | DIRECT |
Poly A polymerase C-terminal region-like | 0 | DIRECT |
RPB5-like RNA polymerase subunit | 0 | DIRECT |
YojJ-like | 0 | DIRECT |
Nucleotidyltransferase | 0 | DIRECT |
Viral leader polypeptide zinc finger | 0 | DIRECT |
RNA polymerase subunits | 0 | DIRECT |
post-AAA+ oligomerization domain-like | 0 | DIRECT |
Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
Nucleotidyltransferase substrate binding subunit/domain | 0 | DIRECT |
Replicase NSP9 | 0 | DIRECT |
Acid proteases | 0 | DIRECT |
Zinc finger domain of DNA polymerase-alpha | 0 | DIRECT |
Coronavirus NSP8-like | 0 | DIRECT |
Coronavirus NSP10-like | 0 | DIRECT |
Poly(A) polymerase catalytic subunit-like | 0 | DIRECT |
Retrovirus zinc finger-like domains | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
PIN domain-like | 0 | DIRECT |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | 0 | DIRECT |
Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
EndoU-like | 0 | DIRECT |
RNA polymerase subunit RPB10 | 0 | DIRECT |
IpsF-like | 0 | DIRECT |
Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
Coronavirus NSP7-like | 0 | DIRECT |
C-terminal domain of RNA polymerase alpha subunit | 0 | DIRECT |
DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
Retroviral matrix proteins | 0 | DIRECT |
Nucleotidylyl transferase | 0 | DIRECT |
Insert subdomain of RNA polymerase alpha subunit | 0 | DIRECT |
DNA-binding domain of retroviral integrase | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | DIRECT |
Nucleotide-diphospho-sugar transferases | 0 | DIRECT |
RPB6/omega subunit-like | 0 | DIRECT |
PsbU/PolX domain-like | 0 | DIRECT |
HD-domain/PDEase-like | 0 | DIRECT |
Nucleic acid-binding proteins | 0 | DIRECT |
PHP domain-like | 0 | DIRECT |
DNA/RNA polymerases | 0 | DIRECT |
Trypsin-like serine proteases | 0 | DIRECT |
Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
Ribosomal protein S5 domain 2-like | 0 | DIRECT |
Trimeric LpxA-like enzymes | 0 | DIRECT |
Positive stranded ssRNA viruses | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
Molybdenum cofactor biosynthesis proteins | 0 | DIRECT |
PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
ACT-like | 0 | DIRECT |
Macro domain-like | 3.548e-16 | DIRECT |
NSP3A-like | 3.548e-16 | DIRECT |
Hedgehog/intein (Hint) domain | 0.00000000001647 | DIRECT |
HIT-like | 0.000000001436 | DIRECT |
Nucleotide cyclase | 0.00000003398 | DIRECT |
Homing endonucleases | 0.0000002451 | DIRECT |
MoeA N-terminal region -like | 0.00001373 | DIRECT |
MoeA C-terminal domain-like | 0.00001373 | DIRECT |
SARS Nsp1-like | 0.00003506 | DIRECT |
Translation proteins | 0.00008761 | DIRECT |
E set domains | 0.0001094 | DIRECT |
CYTH-like phosphatases | 0.001724 | INHERITED FROM: mRNA guanylyltransferase |
beta-beta-alpha zinc fingers | 0.003313 | INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase |
RNA-binding domain, RBD | 0.03978 | INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase |
Zinc beta-ribbon | 0.04145 | INHERITED FROM: DNA-directed RNA polymerase |
TPR-like | 0.05595 | INHERITED FROM: Protein adenylyltransferase |
Ribonuclease Rh-like | 0.06449 | INHERITED FROM: RNA-directed RNA polymerase |
Globin-like | 0.08133 | INHERITED FROM: Diguanylate cyclase |
Sec63 N-terminal domain-like | 0.2307 | INHERITED FROM: DNA-directed DNA polymerase |
DNase I-like | 0.58 | INHERITED FROM: RNA-directed DNA polymerase |
SGNH hydrolase | 0.8544 | INHERITED FROM: N-acylneuraminate cytidylyltransferase |
Clavaminate synthase-like | 0.9357 | INHERITED FROM: RNA-directed RNA polymerase |
lambda repressor-like DNA-binding domains | 0.9418 | INHERITED FROM: Nicotinamide-nucleotide adenylyltransferase |
Adenine nucleotide alpha hydrolases-like | 0.9517 | INHERITED FROM: Sulfate adenylyltransferase || FAD synthase |
BRCT domain | 1 | INHERITED FROM: DNA nucleotidylexotransferase |
RmlC-like cupins | 1 | INHERITED FROM: Mannose-1-phosphate guanylyltransferase |
(Phosphotyrosine protein) phosphatases II | 1 | INHERITED FROM: mRNA guanylyltransferase |
PYP-like sensor domain (PAS domain) | 1 | INHERITED FROM: Diguanylate cyclase |
Ribokinase-like | 1 | INHERITED FROM: D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase |
Protein kinase-like (PK-like) | 1 | INHERITED FROM: Protein adenylyltransferase |
DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: mRNA guanylyltransferase |
Riboflavin kinase-like | 1 | INHERITED FROM: FAD synthase |
Nudix | 1 | INHERITED FROM: ADP-D-ribose pyrophosphorylase |
P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Sulfate adenylyltransferase || RNA-directed RNA polymerase || Adenosylcobinamide-phosphate guanylyltransferase || Polynucleotide adenylyltransferase |
PUA domain-like | 1 | INHERITED FROM: Sulfate adenylyltransferase |
Cysteine proteinases | 1 | INHERITED FROM: RNA-directed RNA polymerase |
HAD-like | 1 | INHERITED FROM: N-acylneuraminate cytidylyltransferase |
dUTPase-like | 1 | INHERITED FROM: RNA-directed DNA polymerase || DNA-directed DNA polymerase |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: mRNA guanylyltransferase || RNA-directed RNA polymerase |
RuvA domain 2-like | 1 | INHERITED FROM: Diadenylate cyclase |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
N-terminal Zn binding domain of HIV integrase | 0 | Direct |
5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
Retrovirus capsid dimerization domain-like | 0 | Direct |
Soluble domain of poliovirus core protein 3a | 0 | Direct |
Ribonuclease H-like | 0 | Direct |
DNA polymerase III chi subunit | 0 | Direct |
Flavivirus capsid protein C | 0 | Direct |
AF1531-like | 0 | Direct |
YrdC/RibB | 0 | Direct |
Fic-like | 0 | Direct |
PAP/OAS1 substrate-binding domain | 0 | Direct |
Poly A polymerase C-terminal region-like | 0 | Direct |
RPB5-like RNA polymerase subunit | 0 | Direct |
YojJ-like | 0 | Direct |
Nucleotidyltransferase | 0 | Direct |
Viral leader polypeptide zinc finger | 0 | Direct |
RNA polymerase subunits | 0 | Direct |
post-AAA+ oligomerization domain-like | 0 | Direct |
Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
Nucleotidyltransferase substrate binding subunit/domain | 0 | Direct |
Replicase NSP9 | 0 | Direct |
Acid proteases | 0 | Direct |
Zinc finger domain of DNA polymerase-alpha | 0 | Direct |
Coronavirus NSP8-like | 0 | Direct |
Coronavirus NSP10-like | 0 | Direct |
Poly(A) polymerase catalytic subunit-like | 0 | Direct |
Retrovirus zinc finger-like domains | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
PIN domain-like | 0 | Direct |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | 0 | Direct |
Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
EndoU-like | 0 | Direct |
RNA polymerase subunit RPB10 | 0 | Direct |
IpsF-like | 0 | Direct |
Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
Coronavirus NSP7-like | 0 | Direct |
C-terminal domain of RNA polymerase alpha subunit | 0 | Direct |
DNA polymerase beta, N-terminal domain-like | 0 | Direct |
Retroviral matrix proteins | 0 | Direct |
Nucleotidylyl transferase | 0 | Direct |
Insert subdomain of RNA polymerase alpha subunit | 0 | Direct |
DNA-binding domain of retroviral integrase | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | Direct |
Nucleotide-diphospho-sugar transferases | 0 | Direct |
RPB6/omega subunit-like | 0 | Direct |
PsbU/PolX domain-like | 0 | Direct |
HD-domain/PDEase-like | 0 | Direct |
Nucleic acid-binding proteins | 0 | Direct |
PHP domain-like | 0 | Direct |
DNA/RNA polymerases | 0 | Direct |
Trypsin-like serine proteases | 0 | Direct |
Viral glycoprotein, central and dimerisation domains | 0 | Direct |
Ribosomal protein S5 domain 2-like | 0 | Direct |
Trimeric LpxA-like enzymes | 0 | Direct |
Positive stranded ssRNA viruses | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
Molybdenum cofactor biosynthesis proteins | 0 | Direct |
PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
ACT-like | 0 | Direct |
Macro domain-like | 3.548e-16 | Direct |
NSP3A-like | 3.548e-16 | Direct |
Hedgehog/intein (Hint) domain | 0.00000000001647 | Direct |
HIT-like | 0.000000001436 | Direct |
Nucleotide cyclase | 0.00000003398 | Direct |
Homing endonucleases | 0.0000002451 | Direct |
MoeA N-terminal region -like | 0.00001373 | Direct |
MoeA C-terminal domain-like | 0.00001373 | Direct |
SARS Nsp1-like | 0.00003506 | Direct |
Translation proteins | 0.00008761 | Direct |
E set domains | 0.0001094 | Direct |
CYTH-like phosphatases | 0.001724 | Inherited |
beta-beta-alpha zinc fingers | 0.003313 | Inherited |
RNA-binding domain, RBD | 0.03978 | Inherited |
Zinc beta-ribbon | 0.04145 | Inherited |
TPR-like | 0.05595 | Inherited |
Ribonuclease Rh-like | 0.06449 | Inherited |
Globin-like | 0.08133 | Inherited |
Sec63 N-terminal domain-like | 0.2307 | Inherited |
DNase I-like | 0.58 | Inherited |
SGNH hydrolase | 0.8544 | Inherited |
Clavaminate synthase-like | 0.9357 | Inherited |
lambda repressor-like DNA-binding domains | 0.9418 | Inherited |
Adenine nucleotide alpha hydrolases-like | 0.9517 | Inherited |
BRCT domain | 1 | Inherited |
RmlC-like cupins | 1 | Inherited |
(Phosphotyrosine protein) phosphatases II | 1 | Inherited |
PYP-like sensor domain (PAS domain) | 1 | Inherited |
Ribokinase-like | 1 | Inherited |
Protein kinase-like (PK-like) | 1 | Inherited |
DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
Riboflavin kinase-like | 1 | Inherited |
Nudix | 1 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
PUA domain-like | 1 | Inherited |
Cysteine proteinases | 1 | Inherited |
HAD-like | 1 | Inherited |
dUTPase-like | 1 | Inherited |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
RuvA domain 2-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,51161 53448 - Nucleotide-diphospho-sugar transferases 51161 - Trimeric LpxA-like enzymes | 0 | DIRECT |
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81301,81891 81301 - Nucleotidyltransferase 81891 - Poly A polymerase C-terminal region-like | 0 | DIRECT |
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
52374,82114 52374 - Nucleotidylyl transferase 82114 - Riboflavin kinase-like | 0 | DIRECT |
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | DIRECT |
55608,56672 55608 - Homing endonucleases 56672 - DNA/RNA polymerases | 0 | DIRECT |
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
81593,81891 81593 - Nucleotidyltransferase substrate binding subunit/domain 81891 - Poly A polymerase C-terminal region-like | 0 | DIRECT |
88697,52374 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | DIRECT |
55666,46915 55666 - Ribonuclease PH domain 2-like 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | DIRECT |
56219,56672 56219 - DNase I-like 56672 - DNA/RNA polymerases | 0 | DIRECT |
47807,53098 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like | 0 | DIRECT |
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases | 0 | DIRECT |
52949,52540 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
64484,-9 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase -9 - PDB | 0 | DIRECT |
48452,140931 48452 - TPR-like 140931 - Fic-like | 0 | DIRECT |
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains | 0 | DIRECT |
56672,100879 56672 - DNA/RNA polymerases 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
53098,53098 53098 - Ribonuclease H-like 53098 - Ribonuclease H-like | 0 | DIRECT |
52799,56091 52799 - (Phosphotyrosine protein) phosphatases II 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
47836,47943 47836 - Retroviral matrix proteins 47943 - Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
64484,64484 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
53613,52374 53613 - Ribokinase-like 52374 - Nucleotidylyl transferase | 0 | DIRECT |
109604,55021 109604 - HD-domain/PDEase-like 55021 - ACT-like | 0 | DIRECT |
88798,50249 88798 - N-terminal, heterodimerisation domain of RBP7 (RpoE) 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47353,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
50249,89550 50249 - Nucleic acid-binding proteins 89550 - PHP domain-like | 0 | DIRECT |
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like | 0 | DIRECT |
54197,54197 54197 - HIT-like 54197 - HIT-like | 0 | DIRECT |
50249,56300 50249 - Nucleic acid-binding proteins 56300 - Metallo-dependent phosphatases | 0 | DIRECT |
56672,90234 56672 - DNA/RNA polymerases 90234 - Zinc finger domain of DNA polymerase-alpha | 0 | DIRECT |
56672,46919 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | DIRECT |
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
53448,69765 53448 - Nucleotide-diphospho-sugar transferases 69765 - IpsF-like | 0 | DIRECT |
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0 | DIRECT |
53098,51283 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0 | DIRECT |
53098,46919 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
54791,50249 54791 - Eukaryotic type KH-domain (KH-domain type I) 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases | 0 | DIRECT |
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like | 0 | DIRECT |
81301,81593 81301 - Nucleotidyltransferase 81593 - Nucleotidyltransferase substrate binding subunit/domain | 0 | DIRECT |
81631,81301 81631 - PAP/OAS1 substrate-binding domain 81301 - Nucleotidyltransferase | 0 | DIRECT |
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0 | DIRECT |
57756,50630 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 0 | DIRECT |
51283,46919 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
55154,56091 55154 - CYTH-like phosphatases 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases | 0 | DIRECT |
56672,55608 56672 - DNA/RNA polymerases 55608 - Homing endonucleases | 0 | DIRECT |
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0 | DIRECT |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
56672,51294 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
53448,51182 53448 - Nucleotide-diphospho-sugar transferases 51182 - RmlC-like cupins | 0 | DIRECT |
51294,56672 51294 - Hedgehog/intein (Hint) domain 56672 - DNA/RNA polymerases | 0 | DIRECT |
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | DIRECT |
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like | 0 | DIRECT |
50465,52540 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
55257,47789 55257 - RBP11-like subunits of RNA polymerase 47789 - C-terminal domain of RNA polymerase alpha subunit | 0 | DIRECT |
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
55666,54791 55666 - Ribonuclease PH domain 2-like 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
53448,52266 53448 - Nucleotide-diphospho-sugar transferases 52266 - SGNH hydrolase | 0 | DIRECT |
56553,55257 56553 - Insert subdomain of RNA polymerase alpha subunit 55257 - RBP11-like subunits of RNA polymerase | 0 | DIRECT |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
47807,56672 47807 - 5' to 3' exonuclease, C-terminal subdomain 56672 - DNA/RNA polymerases | 0 | DIRECT |
53448,56784 53448 - Nucleotide-diphospho-sugar transferases 56784 - HAD-like | 0 | DIRECT |
89550,53098 89550 - PHP domain-like 53098 - Ribonuclease H-like | 0 | DIRECT |
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | DIRECT |
52540,88697 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like | 0 | DIRECT |
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like | 0 | DIRECT |
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52113,47802 52113 - BRCT domain 47802 - DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
81631,57756 81631 - PAP/OAS1 substrate-binding domain 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
46915,54211 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0 | DIRECT |
47943,47353 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
57667,54928 57667 - beta-beta-alpha zinc fingers 54928 - RNA-binding domain, RBD | 0 | DIRECT |
55021,55021 55021 - ACT-like 55021 - ACT-like | 0 | DIRECT |
81891,109604 81891 - Poly A polymerase C-terminal region-like 109604 - HD-domain/PDEase-like | 0 | DIRECT |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000000000009063 | DIRECT |
52374,52374 52374 - Nucleotidylyl transferase 52374 - Nucleotidylyl transferase | 0.0000000001152 | DIRECT |
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000001241 | DIRECT |
57756,51283 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.00000002899 | DIRECT |
51283,50630 51283 - dUTPase-like 50630 - Acid proteases | 0.00000002899 | DIRECT |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.0000003026 | DIRECT |
63882,53218 63882 - MoeA N-terminal region -like 53218 - Molybdenum cofactor biosynthesis proteins | 0.00001373 | DIRECT |
53218,63867 53218 - Molybdenum cofactor biosynthesis proteins 63867 - MoeA C-terminal domain-like | 0.00001373 | DIRECT |
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like | 0.00003506 | DIRECT |
-9,-9 -9 - PDB -9 - PDB | 0.00003506 | DIRECT |
55785,55073 55785 - PYP-like sensor domain (PAS domain) 55073 - Nucleotide cyclase | 0.00006095 | DIRECT |
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.0001719 | DIRECT |
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.003059 | INHERITED FROM: Sulfate adenylyltransferase || Nicotinamide-nucleotide adenylyltransferase |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 1 | INHERITED FROM: mRNA guanylyltransferase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,51161 53448 - Nucleotide-diphospho-sugar transferases 51161 - Trimeric LpxA-like enzymes | 0 | Direct |
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81301,81891 81301 - Nucleotidyltransferase 81891 - Poly A polymerase C-terminal region-like | 0 | Direct |
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
52374,82114 52374 - Nucleotidylyl transferase 82114 - Riboflavin kinase-like | 0 | Direct |
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | Direct |
55608,56672 55608 - Homing endonucleases 56672 - DNA/RNA polymerases | 0 | Direct |
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
81593,81891 81593 - Nucleotidyltransferase substrate binding subunit/domain 81891 - Poly A polymerase C-terminal region-like | 0 | Direct |
88697,52374 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | Direct |
55666,46915 55666 - Ribonuclease PH domain 2-like 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | Direct |
56219,56672 56219 - DNase I-like 56672 - DNA/RNA polymerases | 0 | Direct |
47807,53098 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like | 0 | Direct |
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases | 0 | Direct |
52949,52540 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
64484,-9 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase -9 - PDB | 0 | Direct |
48452,140931 48452 - TPR-like 140931 - Fic-like | 0 | Direct |
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains | 0 | Direct |
56672,100879 56672 - DNA/RNA polymerases 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | Direct |
53098,53098 53098 - Ribonuclease H-like 53098 - Ribonuclease H-like | 0 | Direct |
52799,56091 52799 - (Phosphotyrosine protein) phosphatases II 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
47836,47943 47836 - Retroviral matrix proteins 47943 - Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
64484,64484 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
53613,52374 53613 - Ribokinase-like 52374 - Nucleotidylyl transferase | 0 | Direct |
109604,55021 109604 - HD-domain/PDEase-like 55021 - ACT-like | 0 | Direct |
88798,50249 88798 - N-terminal, heterodimerisation domain of RBP7 (RpoE) 50249 - Nucleic acid-binding proteins | 0 | Direct |
47353,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
50249,89550 50249 - Nucleic acid-binding proteins 89550 - PHP domain-like | 0 | Direct |
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like | 0 | Direct |
54197,54197 54197 - HIT-like 54197 - HIT-like | 0 | Direct |
50249,56300 50249 - Nucleic acid-binding proteins 56300 - Metallo-dependent phosphatases | 0 | Direct |
56672,90234 56672 - DNA/RNA polymerases 90234 - Zinc finger domain of DNA polymerase-alpha | 0 | Direct |
56672,46919 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | Direct |
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
53448,69765 53448 - Nucleotide-diphospho-sugar transferases 69765 - IpsF-like | 0 | Direct |
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0 | Direct |
53098,51283 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0 | Direct |
53098,46919 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
54791,50249 54791 - Eukaryotic type KH-domain (KH-domain type I) 50249 - Nucleic acid-binding proteins | 0 | Direct |
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases | 0 | Direct |
47802,81585 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like | 0 | Direct |
81301,81593 81301 - Nucleotidyltransferase 81593 - Nucleotidyltransferase substrate binding subunit/domain | 0 | Direct |
81631,81301 81631 - PAP/OAS1 substrate-binding domain 81301 - Nucleotidyltransferase | 0 | Direct |
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0 | Direct |
57756,50630 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 0 | Direct |
51283,46919 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
55154,56091 55154 - CYTH-like phosphatases 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases | 0 | Direct |
56672,55608 56672 - DNA/RNA polymerases 55608 - Homing endonucleases | 0 | Direct |
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0 | Direct |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | Direct |
56672,51294 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
53448,51182 53448 - Nucleotide-diphospho-sugar transferases 51182 - RmlC-like cupins | 0 | Direct |
51294,56672 51294 - Hedgehog/intein (Hint) domain 56672 - DNA/RNA polymerases | 0 | Direct |
81585,81301 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | Direct |
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like | 0 | Direct |
50465,52540 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
55257,47789 55257 - RBP11-like subunits of RNA polymerase 47789 - C-terminal domain of RNA polymerase alpha subunit | 0 | Direct |
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0 | Direct |
55666,54791 55666 - Ribonuclease PH domain 2-like 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
53448,52266 53448 - Nucleotide-diphospho-sugar transferases 52266 - SGNH hydrolase | 0 | Direct |
56553,55257 56553 - Insert subdomain of RNA polymerase alpha subunit 55257 - RBP11-like subunits of RNA polymerase | 0 | Direct |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
47807,56672 47807 - 5' to 3' exonuclease, C-terminal subdomain 56672 - DNA/RNA polymerases | 0 | Direct |
53448,56784 53448 - Nucleotide-diphospho-sugar transferases 56784 - HAD-like | 0 | Direct |
89550,53098 89550 - PHP domain-like 53098 - Ribonuclease H-like | 0 | Direct |
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | Direct |
52540,88697 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like | 0 | Direct |
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like | 0 | Direct |
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
52113,47802 52113 - BRCT domain 47802 - DNA polymerase beta, N-terminal domain-like | 0 | Direct |
81631,57756 81631 - PAP/OAS1 substrate-binding domain 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
46915,54211 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0 | Direct |
47943,47353 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
57667,54928 57667 - beta-beta-alpha zinc fingers 54928 - RNA-binding domain, RBD | 0 | Direct |
55021,55021 55021 - ACT-like 55021 - ACT-like | 0 | Direct |
81891,109604 81891 - Poly A polymerase C-terminal region-like 109604 - HD-domain/PDEase-like | 0 | Direct |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000000000009063 | Direct |
52374,52374 52374 - Nucleotidylyl transferase 52374 - Nucleotidylyl transferase | 0.0000000001152 | Direct |
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000001241 | Direct |
57756,51283 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.00000002899 | Direct |
51283,50630 51283 - dUTPase-like 50630 - Acid proteases | 0.00000002899 | Direct |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.0000003026 | Direct |
63882,53218 63882 - MoeA N-terminal region -like 53218 - Molybdenum cofactor biosynthesis proteins | 0.00001373 | Direct |
53218,63867 53218 - Molybdenum cofactor biosynthesis proteins 63867 - MoeA C-terminal domain-like | 0.00001373 | Direct |
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like | 0.00003506 | Direct |
-9,-9 -9 - PDB -9 - PDB | 0.00003506 | Direct |
55785,55073 55785 - PYP-like sensor domain (PAS domain) 55073 - Nucleotide cyclase | 0.00006095 | Direct |
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.0001719 | Direct |
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.003059 | Inherited |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
50447,50465,52540 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55608,56672,51294 55608 - Homing endonucleases 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
51283,46919,53098 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | DIRECT |
53098,56672,90234 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases 90234 - Zinc finger domain of DNA polymerase-alpha | 0 | DIRECT |
46915,54211,55666 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0 | DIRECT |
88723,47807,56672 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain 56672 - DNA/RNA polymerases | 0 | DIRECT |
52949,52540,52540 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,88697,52374 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | DIRECT |
50630,56672,46919 50630 - Acid proteases 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
55666,46915,54211 55666 - Ribonuclease PH domain 2-like 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
53098,56672,51294 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
51294,56672,55608 51294 - Hedgehog/intein (Hint) domain 56672 - DNA/RNA polymerases 55608 - Homing endonucleases | 0 | DIRECT |
52949,52540,56672 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
56672,53098,51283 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0 | DIRECT |
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | DIRECT |
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0 | DIRECT |
52113,47802,81585 52113 - BRCT domain 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like | 0 | DIRECT |
47836,47943,47353 47836 - Retroviral matrix proteins 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
81301,81631,81301 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 81301 - Nucleotidyltransferase | 0 | DIRECT |
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
56553,55257,47789 56553 - Insert subdomain of RNA polymerase alpha subunit 55257 - RBP11-like subunits of RNA polymerase 47789 - C-terminal domain of RNA polymerase alpha subunit | 0 | DIRECT |
-9,-9,-9 -9 - PDB -9 - PDB -9 - PDB | 0 | DIRECT |
56672,53098,46919 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
47353,57756,50630 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 0 | DIRECT |
55666,54791,50249 55666 - Ribonuclease PH domain 2-like 54791 - Eukaryotic type KH-domain (KH-domain type I) 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
56672,53098,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 53098 - Ribonuclease H-like | 0 | DIRECT |
109604,55021,55021 109604 - HD-domain/PDEase-like 55021 - ACT-like 55021 - ACT-like | 0 | DIRECT |
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
64484,-9,-9 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase -9 - PDB -9 - PDB | 0 | DIRECT |
88723,47807,53098 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like | 0 | DIRECT |
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56672,55608,56672 56672 - DNA/RNA polymerases 55608 - Homing endonucleases 56672 - DNA/RNA polymerases | 0 | DIRECT |
54211,55666,54791 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
51283,50630,56672 51283 - dUTPase-like 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
56672,53098,50122 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
88697,52374,52540 88697 - PUA domain-like 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50249,89550,53098 50249 - Nucleic acid-binding proteins 89550 - PHP domain-like 53098 - Ribonuclease H-like | 0 | DIRECT |
81631,81301,81631 81631 - PAP/OAS1 substrate-binding domain 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
56672,46919,53098 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | DIRECT |
81891,109604,55021 81891 - Poly A polymerase C-terminal region-like 109604 - HD-domain/PDEase-like 55021 - ACT-like | 0 | DIRECT |
47807,53098,56672 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases | 0 | DIRECT |
53098,51283,46919 53098 - Ribonuclease H-like 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
53098,46919,53098 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | DIRECT |
52799,56091,50249 52799 - (Phosphotyrosine protein) phosphatases II 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
81301,81631,55003 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
47943,47353,57756 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
57756,50630,56672 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
54211,55666,46915 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | DIRECT |
81301,81631,57756 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | DIRECT |
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | DIRECT |
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0 | DIRECT |
81301,81593,81891 81301 - Nucleotidyltransferase 81593 - Nucleotidyltransferase substrate binding subunit/domain 81891 - Poly A polymerase C-terminal region-like | 0 | DIRECT |
57756,51283,50630 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like 50630 - Acid proteases | 0.00000002899 | DIRECT |
57756,57756,51283 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.000003047 | DIRECT |
47353,57756,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.000003047 | DIRECT |
63882,53218,63867 63882 - MoeA N-terminal region -like 53218 - Molybdenum cofactor biosynthesis proteins 63867 - MoeA C-terminal domain-like | 0.00001373 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | Direct |
50447,50465,52540 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55608,56672,51294 55608 - Homing endonucleases 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
51283,46919,53098 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | Direct |
53098,56672,90234 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases 90234 - Zinc finger domain of DNA polymerase-alpha | 0 | Direct |
46915,54211,55666 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | Direct |
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0 | Direct |
88723,47807,56672 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain 56672 - DNA/RNA polymerases | 0 | Direct |
52949,52540,52540 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,88697,52374 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | Direct |
50630,56672,46919 50630 - Acid proteases 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
55666,46915,54211 55666 - Ribonuclease PH domain 2-like 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
53098,56672,51294 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
51294,56672,55608 51294 - Hedgehog/intein (Hint) domain 56672 - DNA/RNA polymerases 55608 - Homing endonucleases | 0 | Direct |
52949,52540,56672 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
56672,53098,51283 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0 | Direct |
47802,81585,81301 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like 81301 - Nucleotidyltransferase | 0 | Direct |
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0 | Direct |
52113,47802,81585 52113 - BRCT domain 47802 - DNA polymerase beta, N-terminal domain-like 81585 - PsbU/PolX domain-like | 0 | Direct |
47836,47943,47353 47836 - Retroviral matrix proteins 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
81301,81631,81301 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 81301 - Nucleotidyltransferase | 0 | Direct |
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
56553,55257,47789 56553 - Insert subdomain of RNA polymerase alpha subunit 55257 - RBP11-like subunits of RNA polymerase 47789 - C-terminal domain of RNA polymerase alpha subunit | 0 | Direct |
-9,-9,-9 -9 - PDB -9 - PDB -9 - PDB | 0 | Direct |
56672,53098,46919 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
47353,57756,50630 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 0 | Direct |
55666,54791,50249 55666 - Ribonuclease PH domain 2-like 54791 - Eukaryotic type KH-domain (KH-domain type I) 50249 - Nucleic acid-binding proteins | 0 | Direct |
56672,53098,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 53098 - Ribonuclease H-like | 0 | Direct |
109604,55021,55021 109604 - HD-domain/PDEase-like 55021 - ACT-like 55021 - ACT-like | 0 | Direct |
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
64484,-9,-9 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase -9 - PDB -9 - PDB | 0 | Direct |
88723,47807,53098 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like | 0 | Direct |
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56672,55608,56672 56672 - DNA/RNA polymerases 55608 - Homing endonucleases 56672 - DNA/RNA polymerases | 0 | Direct |
54211,55666,54791 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
51283,50630,56672 51283 - dUTPase-like 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0 | Direct |
56672,53098,50122 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
88697,52374,52540 88697 - PUA domain-like 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50249,89550,53098 50249 - Nucleic acid-binding proteins 89550 - PHP domain-like 53098 - Ribonuclease H-like | 0 | Direct |
81631,81301,81631 81631 - PAP/OAS1 substrate-binding domain 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
56672,46919,53098 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | Direct |
81891,109604,55021 81891 - Poly A polymerase C-terminal region-like 109604 - HD-domain/PDEase-like 55021 - ACT-like | 0 | Direct |
47807,53098,56672 47807 - 5' to 3' exonuclease, C-terminal subdomain 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases | 0 | Direct |
53098,51283,46919 53098 - Ribonuclease H-like 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
53098,46919,53098 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0 | Direct |
52799,56091,50249 52799 - (Phosphotyrosine protein) phosphatases II 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
81301,81631,55003 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
47943,47353,57756 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
57756,50630,56672 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0 | Direct |
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
54211,55666,46915 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0 | Direct |
81301,81631,57756 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | Direct |
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | Direct |
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0 | Direct |
81301,81593,81891 81301 - Nucleotidyltransferase 81593 - Nucleotidyltransferase substrate binding subunit/domain 81891 - Poly A polymerase C-terminal region-like | 0 | Direct |
57756,51283,50630 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like 50630 - Acid proteases | 0.00000002899 | Direct |
57756,57756,51283 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.000003047 | Direct |
47353,57756,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.000003047 | Direct |
63882,53218,63867 63882 - MoeA N-terminal region -like 53218 - Molybdenum cofactor biosynthesis proteins 63867 - MoeA C-terminal domain-like | 0.00001373 | Direct |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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