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Enzyme Commission (EC): Acting on ester bonds
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Bacterial GAP domain | 0 | DIRECT |
| Rof/RNase P subunit-like | 0 | DIRECT |
| PH domain-like | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
| EAL domain-like | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| Plant invertase/pectin methylesterase inhibitor | 0 | DIRECT |
| Voltage-gated potassium channels | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Peptidyl-tRNA hydrolase domain-like | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Methylesterase CheB, C-terminal domain | 0 | DIRECT |
| Phospholipase A2, PLA2 | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Peptidyl-tRNA hydrolase-like | 0 | DIRECT |
| Rnp2-like | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| CheY-like | 0 | DIRECT |
| Thermostable phytase (3-phytase) | 0 | DIRECT |
| HAD-like | 0 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0 | DIRECT |
| Ribonuclease H-like | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| XseB-like | 0 | DIRECT |
| Peptidyl-tRNA hydrolase II | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| AlbA-like | 0 | DIRECT |
| SGNH hydrolase | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Viral protein domain | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
| PHP domain-like | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Phospholipase D/nuclease | 0 | DIRECT |
| Microbial ribonucleases | 0 | DIRECT |
| DTD-like | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| L9 N-domain-like | 0 | DIRECT |
| AF0625-like | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| Toprim domain | 0 | DIRECT |
| Phospholipase C/P1 nuclease | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Outer membrane phospholipase A (OMPLA) | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| Holliday junction resolvase RusA | 0 | DIRECT |
| GAF domain-like | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Influenza hemagglutinin (stalk) | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Staphylococcal nuclease | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| Metallo-hydrolase/oxidoreductase | 0 | DIRECT |
| WD40 repeat-like | 0.000000000000001518 | DIRECT |
| Alkaline phosphatase-like | 0.000000000000004014 | DIRECT |
| LigT-like | 0.00000000000001218 | DIRECT |
| Fibronectin type III | 0.00000000000004193 | DIRECT |
| EF-hand | 0.0000000000001419 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000007043 | DIRECT |
| PIN domain-like | 0.0000000004279 | DIRECT |
| DEK C-terminal domain | 0.0000000024 | DIRECT |
| DNA clamp | 0.00000000471 | DIRECT |
| SMAD/FHA domain | 0.00000002733 | DIRECT |
| PX domain | 0.0000001115 | DIRECT |
| Second domain of FERM | 0.0000001742 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0.0000006046 | DIRECT |
| L domain-like | 0.000001211 | DIRECT |
| SH2 domain | 0.000002695 | DIRECT |
| Restriction endonuclease-like | 0.000003823 | DIRECT |
| Integrin alpha N-terminal domain | 0.000005085 | DIRECT |
| GTPase activation domain, GAP | 0.000005085 | DIRECT |
| Ras GEF | 0.000006804 | DIRECT |
| Saposin | 0.000008629 | DIRECT |
| Acid proteases | 0.00003981 | DIRECT |
| Immunoglobulin | 0.00005196 | DIRECT |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.0000548 | DIRECT |
| ssDNA viruses | 0.00009329 | DIRECT |
| Chaperone J-domain | 0.0002533 | DIRECT |
| CYTH-like phosphatases | 0.0009279 | DIRECT |
| NTF2-like | 0.001857 | INHERITED FROM: Phosphoric monoester hydrolases || Sucrose-phosphate phosphatase |
| CRAL/TRIO domain | 0.00276 | INHERITED FROM: Phosphoric monoester hydrolases || Protein-tyrosine-phosphatase |
| HRDC-like | 0.006206 | INHERITED FROM: Ribonuclease D || Exoribonucleases producing 5'-phosphomonoesters |
| Pectin lyase-like | 0.01063 | INHERITED FROM: Carboxylic ester hydrolases || Pectinesterase |
| RNA-binding domain, RBD | 0.0175 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Poly(A)-specific ribonuclease || Phosphoinositide 5-phosphatase |
| Kelch motif | 0.02146 | INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases |
| Non-globular alpha+beta subunits of globular proteins | 0.02594 | INHERITED FROM: Phosphoric monoester hydrolases || Protein-tyrosine-phosphatase |
| Ubiquitin-like | 0.06331 | INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric monoester hydrolases || Protein-tyrosine-phosphatase |
| L30e-like | 0.07769 | INHERITED FROM: Endoribonucleases producing 5'-phosphomonoesters || Ribonuclease P |
| R3H domain | 0.1146 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Poly(A)-specific ribonuclease |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.2215 | INHERITED FROM: Thiolester hydrolases || Oleoyl-[acyl-carrier-protein] hydrolase |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2284 | INHERITED FROM: Deoxyribonuclease V || Endodeoxyribonucleases producing 5'-phosphomonoesters |
| Bet v1-like | 0.2427 | INHERITED FROM: Acetyl-CoA hydrolase || Thiolester hydrolases |
| Quinoprotein alcohol dehydrogenase-like | 0.2527 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Poly(A)-specific ribonuclease |
| PYP-like sensor domain (PAS domain) | 0.3008 | INHERITED FROM: Cyclic-guanylate-specific phosphodiesterase || Phosphoric diester hydrolases || 3',5'-cyclic-AMP phosphodiesterase |
| Hedgehog/intein (Hint) domain | 0.32 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease I |
| Autotransporter | 0.3204 | INHERITED FROM: Carboxylic ester hydrolases |
| ACP-like | 0.3317 | INHERITED FROM: Thiolester hydrolases || Oleoyl-[acyl-carrier-protein] hydrolase |
| Carbonic anhydrase | 0.3769 | INHERITED FROM: Protein-tyrosine-phosphatase |
| FYVE/PHD zinc finger | 0.407 | INHERITED FROM: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase || Phosphoric monoester hydrolases || Phosphatidylinositol-3-phosphatase || Protein-tyrosine-phosphatase |
| Ankyrin repeat | 0.4107 | INHERITED FROM: Lysophospholipase || 1-alkyl-2-acetylglycerophosphocholine esterase || Phosphoric diester hydrolases |
| SH3-domain | 0.4781 | INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric diester hydrolases |
| SAM/Pointed domain | 0.4983 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
| TPR-like | 0.6502 | INHERITED FROM: Protein-serine/threonine phosphatase |
| Starch-binding domain-like | 0.7515 | INHERITED FROM: Glycerophosphocholine phosphodiesterase || Protein-serine/threonine phosphatase || Phosphoric diester hydrolases || Protein-tyrosine-phosphatase |
| HIT-like | 0.9595 | INHERITED FROM: DNA-3'-diphospho-5'-guanosine diphosphatase || Exodeoxyribonucleases producing 5'-phosphomonoesters || Adenosine-5'-diphospho-5'-(DNA) diphosphatase || Exodeoxyribonucleases producing 3'-phosphomonoesters |
| Tudor/PWWP/MBT | 0.9613 | INHERITED FROM: Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoest |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: Exoribonuclease II || Exoribonucleases producing 5'-phosphomonoesters || Ribonuclease E |
| Cysteine proteinases | 1 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Poly(A)-specific ribonuclease |
| Thioredoxin-like | 1 | INHERITED FROM: Phospholipase A(2) |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Protein-tyrosine-phosphatase |
| Terpenoid cyclases/Protein prenyltransferases | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Geranyl diphosphate diphosphatase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase || ADP-ribose 1''-phosphate phosphatase || Oleoyl-[acyl-carrier-protein] hydrolase |
| Glycoside hydrolase/deacetylase | 1 | INHERITED FROM: Acetylxylan esterase |
| Inosine monophosphate dehydrogenase (IMPDH) | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| ClpP/crotonase | 1 | INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase |
| Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: (3S)-malyl-CoA thioesterase |
| ACT-like | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase || Phosphoserine phosphatase |
| Thiolase-like | 1 | INHERITED FROM: Palmitoyl-CoA hydrolase || Acetyl-CoA hydrolase || Thiolester hydrolases || Oleoyl-[acyl-carrier-protein] hydrolase |
| DHH phosphoesterases | 1 | INHERITED FROM: Cyclic-di-AMP phosphodiesterase || 3'(2'),5'-bisphosphate nucleotidase || Phosphoric diester hydrolases |
| AraD/HMP-PK domain-like | 1 | INHERITED FROM: Acireductone synthase |
| Macro domain-like | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase || O-acetyl-ADP-ribose deacetylase || ADP-ribose 1''-phosphate phosphatase || Phosphoric monoester hydrolases |
| Glutaminase/Asparaginase | 1 | INHERITED FROM: Lysophospholipase || 1-alkyl-2-acetylglycerophosphocholine esterase |
| Nucleotidyltransferase | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: Trehalose-phosphatase |
| PDZ domain-like | 1 | INHERITED FROM: Phosphoric monoester hydrolases || Protein-tyrosine-phosphatase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Type III site-specific deoxyribonuclease || Polynucleotide 5'-phosphatase || ADP-ribose 1''-phosphate phosphatase || Exodeoxyribonuclease V || Type I site-specific deoxyribonuclease || Polynucleotide 3'-phosphatase || Fructose-2,6-bisphosphate 2-phosphatase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Acetyl-CoA hydrolase || Carboxylic ester hydrolases || 6-phosphogluconolactonase || Thiolester hydrolases |
| beta-lactamase/transpeptidase-like | 1 | INHERITED FROM: Teichoic acid D-alanine hydrolase |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| TGS-like | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Periplasmic binding protein-like II | 1 | INHERITED FROM: Alkaline phosphatase |
| dUTPase-like | 1 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Retroviral ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters || Exoribonuclease H |
| GroES-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Nucleotide cyclase | 1 | INHERITED FROM: Cyclic-guanylate-specific phosphodiesterase || Phosphoric diester hydrolases |
| Terpenoid synthases | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Geranyl diphosphate diphosphatase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Bacterial GAP domain | 0 | Direct |
| Rof/RNase P subunit-like | 0 | Direct |
| PH domain-like | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| PP2C-like | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| ComB-like | 0 | Direct |
| (Phosphotyrosine protein) phosphatases II | 0 | Direct |
| EAL domain-like | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| Plant invertase/pectin methylesterase inhibitor | 0 | Direct |
| Voltage-gated potassium channels | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| DNase I-like | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Peptidyl-tRNA hydrolase domain-like | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Methylesterase CheB, C-terminal domain | 0 | Direct |
| Phospholipase A2, PLA2 | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Peptidyl-tRNA hydrolase-like | 0 | Direct |
| Rnp2-like | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| CheY-like | 0 | Direct |
| Thermostable phytase (3-phytase) | 0 | Direct |
| HAD-like | 0 | Direct |
| Phosphotyrosine protein phosphatases I | 0 | Direct |
| Ribonuclease H-like | 0 | Direct |
| SurE-like | 0 | Direct |
| XseB-like | 0 | Direct |
| Peptidyl-tRNA hydrolase II | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| His-Me finger endonucleases | 0 | Direct |
| AlbA-like | 0 | Direct |
| SGNH hydrolase | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Viral protein domain | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
| PHP domain-like | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Phospholipase D/nuclease | 0 | Direct |
| Microbial ribonucleases | 0 | Direct |
| DTD-like | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| L9 N-domain-like | 0 | Direct |
| AF0625-like | 0 | Direct |
| PAZ domain | 0 | Direct |
| Nitrous oxide reductase, N-terminal domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| Toprim domain | 0 | Direct |
| Phospholipase C/P1 nuclease | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Outer membrane phospholipase A (OMPLA) | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| Metallo-dependent phosphatases | 0 | Direct |
| Holliday junction resolvase RusA | 0 | Direct |
| GAF domain-like | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| Influenza hemagglutinin (stalk) | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Staphylococcal nuclease | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| Metallo-hydrolase/oxidoreductase | 0 | Direct |
| WD40 repeat-like | 0.000000000000001518 | Direct |
| Alkaline phosphatase-like | 0.000000000000004014 | Direct |
| LigT-like | 0.00000000000001218 | Direct |
| Fibronectin type III | 0.00000000000004193 | Direct |
| EF-hand | 0.0000000000001419 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000007043 | Direct |
| PIN domain-like | 0.0000000004279 | Direct |
| DEK C-terminal domain | 0.0000000024 | Direct |
| DNA clamp | 0.00000000471 | Direct |
| SMAD/FHA domain | 0.00000002733 | Direct |
| PX domain | 0.0000001115 | Direct |
| Second domain of FERM | 0.0000001742 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0.0000006046 | Direct |
| L domain-like | 0.000001211 | Direct |
| SH2 domain | 0.000002695 | Direct |
| Restriction endonuclease-like | 0.000003823 | Direct |
| Integrin alpha N-terminal domain | 0.000005085 | Direct |
| GTPase activation domain, GAP | 0.000005085 | Direct |
| Ras GEF | 0.000006804 | Direct |
| Saposin | 0.000008629 | Direct |
| Acid proteases | 0.00003981 | Direct |
| Immunoglobulin | 0.00005196 | Direct |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.0000548 | Direct |
| ssDNA viruses | 0.00009329 | Direct |
| Chaperone J-domain | 0.0002533 | Direct |
| CYTH-like phosphatases | 0.0009279 | Direct |
| NTF2-like | 0.001857 | Inherited |
| CRAL/TRIO domain | 0.00276 | Inherited |
| HRDC-like | 0.006206 | Inherited |
| Pectin lyase-like | 0.01063 | Inherited |
| RNA-binding domain, RBD | 0.0175 | Inherited |
| Kelch motif | 0.02146 | Inherited |
| Non-globular alpha+beta subunits of globular proteins | 0.02594 | Inherited |
| Ubiquitin-like | 0.06331 | Inherited |
| L30e-like | 0.07769 | Inherited |
| R3H domain | 0.1146 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.2215 | Inherited |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2284 | Inherited |
| Bet v1-like | 0.2427 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.2527 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.3008 | Inherited |
| Hedgehog/intein (Hint) domain | 0.32 | Inherited |
| Autotransporter | 0.3204 | Inherited |
| ACP-like | 0.3317 | Inherited |
| Carbonic anhydrase | 0.3769 | Inherited |
| FYVE/PHD zinc finger | 0.407 | Inherited |
| Ankyrin repeat | 0.4107 | Inherited |
| SH3-domain | 0.4781 | Inherited |
| SAM/Pointed domain | 0.4983 | Inherited |
| TPR-like | 0.6502 | Inherited |
| Starch-binding domain-like | 0.7515 | Inherited |
| HIT-like | 0.9595 | Inherited |
| Tudor/PWWP/MBT | 0.9613 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| Cysteine proteinases | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
| Terpenoid cyclases/Protein prenyltransferases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Glycoside hydrolase/deacetylase | 1 | Inherited |
| Inosine monophosphate dehydrogenase (IMPDH) | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
| ACT-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| DHH phosphoesterases | 1 | Inherited |
| AraD/HMP-PK domain-like | 1 | Inherited |
| Macro domain-like | 1 | Inherited |
| Glutaminase/Asparaginase | 1 | Inherited |
| Nucleotidyltransferase | 1 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| beta-lactamase/transpeptidase-like | 1 | Inherited |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
| TGS-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Periplasmic binding protein-like II | 1 | Inherited |
| dUTPase-like | 1 | Inherited |
| GroES-like | 1 | Inherited |
| Nucleotide cyclase | 1 | Inherited |
| Terpenoid synthases | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Sphingomyelin phosphodiesterase-like | 0 | DIRECT |
| RecU-like | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| HTLV-II matrix protein | 0 | DIRECT |
| Methylesterase CheB, C-terminal domain | 0 | DIRECT |
| tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase | 0 | DIRECT |
| Acyl-CoA thioesterase | 0 | DIRECT |
| Plant invertase/pectin methylesterase inhibitor | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Phospholipase C | 0 | DIRECT |
| Carboxylesterase | 0 | DIRECT |
| YihX-like | 0 | DIRECT |
| Esterase | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Lysophospholipase | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| Hypothetical esterase YJL068C | 0 | DIRECT |
| Phosphotriesterase-like | 0 | DIRECT |
| Insect phospholipase A2 | 0 | DIRECT |
| RNase P subunit p30 | 0 | DIRECT |
| Ribonuclease H | 0 | DIRECT |
| DTD-like | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| Alpha-toxin, C-terminal domain | 0 | DIRECT |
| Gastric lipase | 0 | DIRECT |
| Vertebrate phospholipase A2 | 0 | DIRECT |
| MtnX-like | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Peptidyl-tRNA hydrolase domain | 0 | DIRECT |
| Class B acid phosphatase, AphA | 0 | DIRECT |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | DIRECT |
| Exodeoxyribonuclease V beta chain (RecC), C-terminal domain | 0 | DIRECT |
| GAF domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| Phosphoserine phosphatase | 0 | DIRECT |
| Cutinase-like | 0 | DIRECT |
| Biotin biosynthesis protein BioH | 0 | DIRECT |
| Fungal lipases | 0 | DIRECT |
| AF0625-like | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Predicted hydrolases Cof | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| Purple acid phosphatase-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| GRAM domain | 0 | DIRECT |
| Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | DIRECT |
| Hjc-like | 0 | DIRECT |
| 2'-5' RNA ligase LigT | 0 | DIRECT |
| RuvC resolvase | 0 | DIRECT |
| Retrovirus capsid protein C-terminal domain | 0 | DIRECT |
| Peptidyl-tRNA hydrolase II | 0 | DIRECT |
| XseB-like | 0 | DIRECT |
| EAL domain | 0 | DIRECT |
| Pectin methylesterase | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Outer membrane phospholipase A (OMPLA) | 0 | DIRECT |
| mRNA triphosphatase CET1 | 0 | DIRECT |
| Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | DIRECT |
| Histidine acid phosphatase | 0 | DIRECT |
| PDEase | 0 | DIRECT |
| SGL-like | 0 | DIRECT |
| Acyl-ACP thioesterase-like | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| RNB domain-like | 0 | DIRECT |
| DNA/RNA non-specific endonuclease | 0 | DIRECT |
| Thioesterases | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Enolase-phosphatase E1 | 0 | DIRECT |
| RNase P subunit p29-like | 0 | DIRECT |
| Influenza hemagglutinin (stalk) | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| Immunodeficiency virus matrix proteins | 0 | DIRECT |
| GlpX-like bacterial fructose-1,6-bisphosphatase | 0 | DIRECT |
| Trehalose-phosphatase | 0 | DIRECT |
| Pancreatic lipase, N-terminal domain | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| Endonuclease I | 0 | DIRECT |
| CAF1-like ribonuclease | 0 | DIRECT |
| Putative acetylxylan esterase-like | 0 | DIRECT |
| RNase Z-like | 0 | DIRECT |
| GAG polyprotein M-domain | 0 | DIRECT |
| Nuclease | 0 | DIRECT |
| Retroviral integrase, catalytic domain | 0 | DIRECT |
| MMLV matrix protein-like | 0 | DIRECT |
| Acetylcholinesterase-like | 0 | DIRECT |
| RNase P protein | 0 | DIRECT |
| Holliday junction resolvase RusA | 0 | DIRECT |
| Bacterial lipase | 0 | DIRECT |
| P1 nuclease | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| Patatin | 0 | DIRECT |
| CheY-related | 0 | DIRECT |
| GpdQ-like | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Endonuclease IV | 0 | DIRECT |
| beta-Phosphoglucomutase-like | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| 4HBT-like | 0 | DIRECT |
| Staphylococcal nuclease | 0 | DIRECT |
| Peptidyl-tRNA hydrolase-like | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0 | DIRECT |
| Reverse transcriptase | 0 | DIRECT |
| 2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain | 0 | DIRECT |
| RNase D C-terminal domains | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| Rpp14/Pop5-like | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Protein serine/threonine phosphatase | 0 | DIRECT |
| Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
| Toprim domain | 0 | DIRECT |
| Colipase-binding domain | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Retroviral protease (retropepsin) | 0 | DIRECT |
| Type 2 phosphatidic acid phosphatase, PAP2 | 0 | DIRECT |
| Bacterial ribonucleases | 0 | DIRECT |
| Pyrimidine 5'-nucleotidase (UMPH-1) | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| DnaQ-like 3'-5' exonuclease | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Fungal ribonucleases | 0 | DIRECT |
| Parvoviridae-like VP | 0 | DIRECT |
| N-terminal domain of RNase HI | 0 | DIRECT |
| Bacterial GAP domain | 0 | DIRECT |
| TAP-like | 0 | DIRECT |
| Dienelactone hydrolase | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Magnesium-dependent phosphatase-1, Mdp1 | 0 | DIRECT |
| CRAL/TRIO domain | 0 | DIRECT |
| Thermostable phytase (3-phytase) | 0 | DIRECT |
| 5' nucleotidase-like | 0 | DIRECT |
| Virulence effector SptP domain | 0 | DIRECT |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| Fibronectin type III | 0.00000000000001155 | DIRECT |
| Acetylhydrolase | 0.00000000001252 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0.00000000001524 | DIRECT |
| Cold shock DNA-binding domain-like | 0.00000000002236 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000003263 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.00000000003263 | DIRECT |
| DNase I-like | 0.0000000001853 | DIRECT |
| Third domain of FERM | 0.0000000003791 | DIRECT |
| phosphatase domain of polynucleotide kinase | 0.000000003442 | DIRECT |
| First domain of FERM | 0.0000000277 | DIRECT |
| FHA domain | 0.00000005402 | DIRECT |
| Second domain of FERM | 0.00000008624 | DIRECT |
| DEK C-terminal domain | 0.0000003701 | DIRECT |
| Acyl-carrier protein (ACP) | 0.0000003701 | DIRECT |
| I set domains | 0.0000004823 | DIRECT |
| Probable phosphatase YrbI | 0.0000008377 | DIRECT |
| PaaI/YdiI-like | 0.0000009383 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0.000001104 | DIRECT |
| SH2 domain | 0.000001668 | DIRECT |
| PHP domain | 0.000003143 | DIRECT |
| BCR-homology GTPase activation domain (BH-domain) | 0.000003887 | DIRECT |
| PX domain | 0.000004169 | DIRECT |
| NagD-like | 0.000005187 | DIRECT |
| Ras GEF | 0.000005236 | DIRECT |
| RelA/SpoT domain | 0.000007785 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00001313 | DIRECT |
| Canonical RBD | 0.00001779 | DIRECT |
| CoA transferase alpha subunit-like | 0.00002834 | DIRECT |
| Leucine rich effector protein YopM | 0.00003546 | DIRECT |
| PDZ domain | 0.00003956 | DIRECT |
| Macro domain | 0.00004103 | DIRECT |
| Hydroxynitrile lyase-like | 0.00007188 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0001062 | DIRECT |
| Chaperone J-domain | 0.0002027 | DIRECT |
| MaoC-like | 0.0003157 | DIRECT |
| FabD-like | 0.0003997 | DIRECT |
| Haloperoxidase | 0.0008423 | DIRECT |
| mRNA capping enzyme | 0.001088 | INHERITED FROM: Polynucleotide 5'-phosphatase || Phosphoric monoester hydrolases |
| PP1699/LP2961-like | 0.001547 | INHERITED FROM: Carboxylic ester hydrolases |
| Mason-Pfizer monkey virus matrix protein | 0.01438 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
| MAM domain | 0.0157 | INHERITED FROM: Phosphoric monoester hydrolases || Protein-tyrosine-phosphatase |
| HpcH/HpaI aldolase | 0.02666 | INHERITED FROM: Thiolester hydrolases || (3S)-malyl-CoA thioesterase |
| mRNA cap (Guanine N-7) methyltransferase | 0.02934 | INHERITED FROM: Polynucleotide 5'-phosphatase || Phosphoric monoester hydrolases |
| WD40-repeat | 0.03651 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Poly(A)-specific ribonuclease |
| Ras-binding domain, RBD | 0.05416 | INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric diester hydrolases |
| GGDEF domain | 0.0665 | INHERITED FROM: Cyclic-guanylate-specific phosphodiesterase || Phosphoric diester hydrolases |
| 5' to 3' exonuclease catalytic domain | 0.07317 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease (lambda-induced) |
| Ubiquitin-related | 0.0869 | INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases |
| R3H domain | 0.09192 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Poly(A)-specific ribonuclease |
| Tetratricopeptide repeat (TPR) | 0.1895 | INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2016 | INHERITED FROM: Deoxyribonuclease V || Endodeoxyribonucleases producing 5'-phosphomonoesters |
| SAM (sterile alpha motif) domain | 0.2046 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase || Phosphoric monoester hydrolases |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.2356 | INHERITED FROM: Thiolester hydrolases || Oleoyl-[acyl-carrier-protein] hydrolase |
| Tudor domain | 0.2785 | INHERITED FROM: Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoest |
| Carbonic anhydrase | 0.3301 | INHERITED FROM: Protein-tyrosine-phosphatase |
| Ankyrin repeat | 0.3482 | INHERITED FROM: Lysophospholipase || 1-alkyl-2-acetylglycerophosphocholine esterase || Phosphoric diester hydrolases |
| Trehalose-6-phosphate synthase, OtsA | 0.3595 | INHERITED FROM: Trehalose-phosphatase |
| Starch-binding domain | 0.3823 | INHERITED FROM: Glycerophosphocholine phosphodiesterase || Phosphoric diester hydrolases || Protein-tyrosine-phosphatase |
| SH3-domain | 0.4333 | INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric diester hydrolases |
| DNA polymerase I | 0.4771 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
| Glucose 6-phosphate dehydrogenase-like | 0.8364 | INHERITED FROM: 6-phosphogluconolactonase |
| Crotonase-like | 0.8383 | INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase |
| Epoxide hydrolase | 0.916 | INHERITED FROM: Phosphoric monoester hydrolases || Lipid-phosphate phosphatase |
| AraD-like aldolase/epimerase | 0.9276 | INHERITED FROM: Acireductone synthase |
| Cofactor-dependent phosphoglycerate mutase | 0.986 | INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase |
| Carbon-carbon bond hydrolase | 0.9935 | INHERITED FROM: Acylglycerol lipase || Carboxylic ester hydrolases |
| Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 1 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease V |
| Tandem AAA-ATPase domain | 1 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease V |
| Terpenoid cyclase N-terminal domain | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Geranyl diphosphate diphosphatase |
| Terpenoid cyclase C-terminal domain | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Geranyl diphosphate diphosphatase |
| Thiolase-related | 1 | INHERITED FROM: Palmitoyl-CoA hydrolase || Acetyl-CoA hydrolase || Thiolester hydrolases || Oleoyl-[acyl-carrier-protein] hydrolase |
| Glutaminase/Asparaginase | 1 | INHERITED FROM: Lysophospholipase || 1-alkyl-2-acetylglycerophosphocholine esterase |
| Phosphate binding protein-like | 1 | INHERITED FROM: Alkaline phosphatase |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| beta-Lactamase/D-ala carboxypeptidase | 1 | INHERITED FROM: Teichoic acid D-alanine hydrolase |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Nucleotide and nucleoside kinases | 1 | INHERITED FROM: Polynucleotide 3'-phosphatase |
| NagB-like | 1 | INHERITED FROM: Carboxylic ester hydrolases || 6-phosphogluconolactonase |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| dUTPase-like | 1 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Retroviral ribonuclease H || Exoribonuclease H |
| Glutathione peroxidase-like | 1 | INHERITED FROM: Phospholipase A(2) |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Sphingomyelin phosphodiesterase-like | 0 | Direct |
| RecU-like | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| HTLV-II matrix protein | 0 | Direct |
| Methylesterase CheB, C-terminal domain | 0 | Direct |
| tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase | 0 | Direct |
| Acyl-CoA thioesterase | 0 | Direct |
| Plant invertase/pectin methylesterase inhibitor | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Phospholipase C | 0 | Direct |
| Carboxylesterase | 0 | Direct |
| YihX-like | 0 | Direct |
| Esterase | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Lysophospholipase | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| Hypothetical esterase YJL068C | 0 | Direct |
| Phosphotriesterase-like | 0 | Direct |
| Insect phospholipase A2 | 0 | Direct |
| RNase P subunit p30 | 0 | Direct |
| Ribonuclease H | 0 | Direct |
| DTD-like | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| Alpha-toxin, C-terminal domain | 0 | Direct |
| Gastric lipase | 0 | Direct |
| Vertebrate phospholipase A2 | 0 | Direct |
| MtnX-like | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Peptidyl-tRNA hydrolase domain | 0 | Direct |
| Class B acid phosphatase, AphA | 0 | Direct |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | Direct |
| Exodeoxyribonuclease V beta chain (RecC), C-terminal domain | 0 | Direct |
| GAF domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| Phosphoserine phosphatase | 0 | Direct |
| Cutinase-like | 0 | Direct |
| Biotin biosynthesis protein BioH | 0 | Direct |
| Fungal lipases | 0 | Direct |
| AF0625-like | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Predicted hydrolases Cof | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| Purple acid phosphatase-like | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| GRAM domain | 0 | Direct |
| Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | Direct |
| Hjc-like | 0 | Direct |
| 2'-5' RNA ligase LigT | 0 | Direct |
| RuvC resolvase | 0 | Direct |
| Retrovirus capsid protein C-terminal domain | 0 | Direct |
| Peptidyl-tRNA hydrolase II | 0 | Direct |
| XseB-like | 0 | Direct |
| EAL domain | 0 | Direct |
| Pectin methylesterase | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Outer membrane phospholipase A (OMPLA) | 0 | Direct |
| mRNA triphosphatase CET1 | 0 | Direct |
| Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | Direct |
| Histidine acid phosphatase | 0 | Direct |
| PDEase | 0 | Direct |
| SGL-like | 0 | Direct |
| Acyl-ACP thioesterase-like | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| RNB domain-like | 0 | Direct |
| DNA/RNA non-specific endonuclease | 0 | Direct |
| Thioesterases | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Enolase-phosphatase E1 | 0 | Direct |
| RNase P subunit p29-like | 0 | Direct |
| Influenza hemagglutinin (stalk) | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| Immunodeficiency virus matrix proteins | 0 | Direct |
| GlpX-like bacterial fructose-1,6-bisphosphatase | 0 | Direct |
| Trehalose-phosphatase | 0 | Direct |
| Pancreatic lipase, N-terminal domain | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| Endonuclease I | 0 | Direct |
| CAF1-like ribonuclease | 0 | Direct |
| Putative acetylxylan esterase-like | 0 | Direct |
| RNase Z-like | 0 | Direct |
| GAG polyprotein M-domain | 0 | Direct |
| Nuclease | 0 | Direct |
| Retroviral integrase, catalytic domain | 0 | Direct |
| MMLV matrix protein-like | 0 | Direct |
| Acetylcholinesterase-like | 0 | Direct |
| RNase P protein | 0 | Direct |
| Holliday junction resolvase RusA | 0 | Direct |
| Bacterial lipase | 0 | Direct |
| P1 nuclease | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| Patatin | 0 | Direct |
| CheY-related | 0 | Direct |
| GpdQ-like | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Endonuclease IV | 0 | Direct |
| beta-Phosphoglucomutase-like | 0 | Direct |
| SurE-like | 0 | Direct |
| 4HBT-like | 0 | Direct |
| Staphylococcal nuclease | 0 | Direct |
| Peptidyl-tRNA hydrolase-like | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0 | Direct |
| Reverse transcriptase | 0 | Direct |
| 2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain | 0 | Direct |
| RNase D C-terminal domains | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| PAZ domain | 0 | Direct |
| Rpp14/Pop5-like | 0 | Direct |
| HD domain | 0 | Direct |
| Protein serine/threonine phosphatase | 0 | Direct |
| Nitrous oxide reductase, N-terminal domain | 0 | Direct |
| Toprim domain | 0 | Direct |
| Colipase-binding domain | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Retroviral protease (retropepsin) | 0 | Direct |
| Type 2 phosphatidic acid phosphatase, PAP2 | 0 | Direct |
| Bacterial ribonucleases | 0 | Direct |
| Pyrimidine 5'-nucleotidase (UMPH-1) | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| DnaQ-like 3'-5' exonuclease | 0 | Direct |
| ComB-like | 0 | Direct |
| Fungal ribonucleases | 0 | Direct |
| Parvoviridae-like VP | 0 | Direct |
| N-terminal domain of RNase HI | 0 | Direct |
| Bacterial GAP domain | 0 | Direct |
| TAP-like | 0 | Direct |
| Dienelactone hydrolase | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| Magnesium-dependent phosphatase-1, Mdp1 | 0 | Direct |
| CRAL/TRIO domain | 0 | Direct |
| Thermostable phytase (3-phytase) | 0 | Direct |
| 5' nucleotidase-like | 0 | Direct |
| Virulence effector SptP domain | 0 | Direct |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| Fibronectin type III | 0.00000000000001155 | Direct |
| Acetylhydrolase | 0.00000000001252 | Direct |
| Pleckstrin-homology domain (PH domain) | 0.00000000001524 | Direct |
| Cold shock DNA-binding domain-like | 0.00000000002236 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000003263 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.00000000003263 | Direct |
| DNase I-like | 0.0000000001853 | Direct |
| Third domain of FERM | 0.0000000003791 | Direct |
| phosphatase domain of polynucleotide kinase | 0.000000003442 | Direct |
| First domain of FERM | 0.0000000277 | Direct |
| FHA domain | 0.00000005402 | Direct |
| Second domain of FERM | 0.00000008624 | Direct |
| DEK C-terminal domain | 0.0000003701 | Direct |
| Acyl-carrier protein (ACP) | 0.0000003701 | Direct |
| I set domains | 0.0000004823 | Direct |
| Probable phosphatase YrbI | 0.0000008377 | Direct |
| PaaI/YdiI-like | 0.0000009383 | Direct |
| Imidazole glycerol phosphate dehydratase | 0.000001104 | Direct |
| SH2 domain | 0.000001668 | Direct |
| PHP domain | 0.000003143 | Direct |
| BCR-homology GTPase activation domain (BH-domain) | 0.000003887 | Direct |
| PX domain | 0.000004169 | Direct |
| NagD-like | 0.000005187 | Direct |
| Ras GEF | 0.000005236 | Direct |
| RelA/SpoT domain | 0.000007785 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.00001313 | Direct |
| Canonical RBD | 0.00001779 | Direct |
| CoA transferase alpha subunit-like | 0.00002834 | Direct |
| Leucine rich effector protein YopM | 0.00003546 | Direct |
| PDZ domain | 0.00003956 | Direct |
| Macro domain | 0.00004103 | Direct |
| Hydroxynitrile lyase-like | 0.00007188 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0001062 | Direct |
| Chaperone J-domain | 0.0002027 | Direct |
| MaoC-like | 0.0003157 | Direct |
| FabD-like | 0.0003997 | Direct |
| Haloperoxidase | 0.0008423 | Direct |
| mRNA capping enzyme | 0.001088 | Inherited |
| PP1699/LP2961-like | 0.001547 | Inherited |
| Mason-Pfizer monkey virus matrix protein | 0.01438 | Inherited |
| MAM domain | 0.0157 | Inherited |
| HpcH/HpaI aldolase | 0.02666 | Inherited |
| mRNA cap (Guanine N-7) methyltransferase | 0.02934 | Inherited |
| WD40-repeat | 0.03651 | Inherited |
| Ras-binding domain, RBD | 0.05416 | Inherited |
| GGDEF domain | 0.0665 | Inherited |
| 5' to 3' exonuclease catalytic domain | 0.07317 | Inherited |
| Ubiquitin-related | 0.0869 | Inherited |
| R3H domain | 0.09192 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.1895 | Inherited |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2016 | Inherited |
| SAM (sterile alpha motif) domain | 0.2046 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.2356 | Inherited |
| Tudor domain | 0.2785 | Inherited |
| Carbonic anhydrase | 0.3301 | Inherited |
| Ankyrin repeat | 0.3482 | Inherited |
| Trehalose-6-phosphate synthase, OtsA | 0.3595 | Inherited |
| Starch-binding domain | 0.3823 | Inherited |
| SH3-domain | 0.4333 | Inherited |
| DNA polymerase I | 0.4771 | Inherited |
| Glucose 6-phosphate dehydrogenase-like | 0.8364 | Inherited |
| Crotonase-like | 0.8383 | Inherited |
| Epoxide hydrolase | 0.916 | Inherited |
| AraD-like aldolase/epimerase | 0.9276 | Inherited |
| Cofactor-dependent phosphoglycerate mutase | 0.986 | Inherited |
| Carbon-carbon bond hydrolase | 0.9935 | Inherited |
| Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 1 | Inherited |
| Tandem AAA-ATPase domain | 1 | Inherited |
| Terpenoid cyclase N-terminal domain | 1 | Inherited |
| Terpenoid cyclase C-terminal domain | 1 | Inherited |
| Thiolase-related | 1 | Inherited |
| Glutaminase/Asparaginase | 1 | Inherited |
| Phosphate binding protein-like | 1 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| beta-Lactamase/D-ala carboxypeptidase | 1 | Inherited |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Nucleotide and nucleoside kinases | 1 | Inherited |
| NagB-like | 1 | Inherited |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | Inherited |
| dUTPase-like | 1 | Inherited |
| Glutathione peroxidase-like | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| Voltage-gated potassium channels | 0 | DIRECT |
| Ribonuclease H-like | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Peptidyl-tRNA hydrolase-like | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Toprim domain | 0 | DIRECT |
| (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| GAF domain-like | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| SGNH hydrolase | 0 | DIRECT |
| Peptidyl-tRNA hydrolase II | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| EAL domain-like | 0 | DIRECT |
| L9 N-domain-like | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
| Rof/RNase P subunit-like | 0 | DIRECT |
| CheY-like | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Thermostable phytase (3-phytase) | 0 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Outer membrane phospholipase A (OMPLA) | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Staphylococcal nuclease | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| Phospholipase A2, PLA2 | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| Phospholipase D/nuclease | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| Metallo-hydrolase/oxidoreductase | 0 | DIRECT |
| Methylesterase CheB, C-terminal domain | 0 | DIRECT |
| Viral protein domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| PH domain-like | 0 | DIRECT |
| AlbA-like | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Peptidyl-tRNA hydrolase domain-like | 0 | DIRECT |
| Influenza hemagglutinin (stalk) | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| DTD-like | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Holliday junction resolvase RusA | 0 | DIRECT |
| Microbial ribonucleases | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| AF0625-like | 0 | DIRECT |
| PHP domain-like | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| HAD-like | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Bacterial GAP domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| XseB-like | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Phospholipase C/P1 nuclease | 0 | DIRECT |
| Rnp2-like | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| Plant invertase/pectin methylesterase inhibitor | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| WD40 repeat-like | 0.000000000000001059 | DIRECT |
| Alkaline phosphatase-like | 0.000000000000002809 | DIRECT |
| LigT-like | 0.000000000000008551 | DIRECT |
| Fibronectin type III | 0.00000000000002957 | DIRECT |
| EF-hand | 0.0000000000001006 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000005154 | DIRECT |
| PIN domain-like | 0.0000000003167 | DIRECT |
| DEK C-terminal domain | 0.000000001795 | DIRECT |
| DNA clamp | 0.000000003538 | DIRECT |
| SMAD/FHA domain | 0.00000002074 | DIRECT |
| PX domain | 0.00000008526 | DIRECT |
| Second domain of FERM | 0.0000001336 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0.0000004689 | DIRECT |
| L domain-like | 0.0000009439 | DIRECT |
| SH2 domain | 0.000002113 | DIRECT |
| Restriction endonuclease-like | 0.000003005 | DIRECT |
| GTPase activation domain, GAP | 0.000003999 | DIRECT |
| Integrin alpha N-terminal domain | 0.000003999 | DIRECT |
| Ras GEF | 0.000005358 | DIRECT |
| Saposin | 0.000006809 | DIRECT |
| Acid proteases | 0.00003183 | DIRECT |
| Immunoglobulin | 0.00004162 | DIRECT |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.00004392 | DIRECT |
| ssDNA viruses | 0.00007515 | DIRECT |
| Chaperone J-domain | 0.0002059 | DIRECT |
| CYTH-like phosphatases | 0.0007645 | DIRECT |
| NTF2-like | 0.001543 | INHERITED FROM: Sucrose-phosphate phosphatase || Phosphoric monoester hydrolases |
| CRAL/TRIO domain | 0.002304 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| HRDC-like | 0.005222 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Ribonuclease D |
| Pectin lyase-like | 0.009007 | INHERITED FROM: Pectinesterase || Carboxylic ester hydrolases |
| RNA-binding domain, RBD | 0.01492 | INHERITED FROM: Poly(A)-specific ribonuclease || Phosphoinositide 5-phosphatase || Exoribonucleases producing 5'-phosphomonoesters |
| Kelch motif | 0.01835 | INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases |
| Non-globular alpha+beta subunits of globular proteins | 0.02223 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| Ubiquitin-like | 0.05491 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases || Phosphoinositide phospholipase C |
| L30e-like | 0.0675 | INHERITED FROM: Ribonuclease P || Endoribonucleases producing 5'-phosphomonoesters |
| R3H domain | 0.1002 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1969 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2031 | INHERITED FROM: Endodeoxyribonucleases producing 5'-phosphomonoesters || Deoxyribonuclease V |
| Bet v1-like | 0.2164 | INHERITED FROM: Thiolester hydrolases || Acetyl-CoA hydrolase |
| Quinoprotein alcohol dehydrogenase-like | 0.2255 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| PYP-like sensor domain (PAS domain) | 0.2714 | INHERITED FROM: 3',5'-cyclic-AMP phosphodiesterase || Cyclic-guanylate-specific phosphodiesterase || Phosphoric diester hydrolases |
| Hedgehog/intein (Hint) domain | 0.2891 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease I |
| Autotransporter | 0.2895 | INHERITED FROM: Carboxylic ester hydrolases |
| ACP-like | 0.2997 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| Carbonic anhydrase | 0.3413 | INHERITED FROM: Protein-tyrosine-phosphatase |
| FYVE/PHD zinc finger | 0.369 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphatidylinositol-3-phosphatase || Phosphoric monoester hydrolases || Phosphatidylinositol-3,5-bisphosphate 3-phosphatase |
| Ankyrin repeat | 0.3725 | INHERITED FROM: 1-alkyl-2-acetylglycerophosphocholine esterase || Lysophospholipase || Phosphoric diester hydrolases |
| SH3-domain | 0.436 | INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C |
| SAM/Pointed domain | 0.455 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
| TPR-like | 0.5971 | INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases |
| Starch-binding domain-like | 0.6913 | INHERITED FROM: Protein-tyrosine-phosphatase || Glycerophosphocholine phosphodiesterase || Phosphoric diester hydrolases || Protein-serine/threonine phosphatase |
| HIT-like | 0.8877 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Exodeoxyribonucleases producing 3'-phosphomonoesters || Adenosine-5'-diphospho-5'-(DNA) diphosphatase || DNA-3'-diphospho-5'-guanosine diphosphatase |
| Tudor/PWWP/MBT | 0.8894 | INHERITED FROM: Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoest |
| AraD/HMP-PK domain-like | 0.9316 | INHERITED FROM: Acireductone synthase |
| Glutaminase/Asparaginase | 1 | INHERITED FROM: 1-alkyl-2-acetylglycerophosphocholine esterase || Lysophospholipase |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: Trehalose-phosphatase |
| Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: (3S)-malyl-CoA thioesterase |
| ClpP/crotonase | 1 | INHERITED FROM: 3-hydroxyisobutyryl-CoA hydrolase || Thiolester hydrolases |
| Terpenoid synthases | 1 | INHERITED FROM: Geranyl diphosphate diphosphatase || Diphosphoric monoester hydrolases |
| Glycoside hydrolase/deacetylase | 1 | INHERITED FROM: Acetylxylan esterase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: 6-phosphogluconolactonase || Thiolester hydrolases || Carboxylic ester hydrolases || Acetyl-CoA hydrolase |
| Thioredoxin-like | 1 | INHERITED FROM: Phospholipase A(2) |
| Nucleotide cyclase | 1 | INHERITED FROM: Cyclic-guanylate-specific phosphodiesterase || Phosphoric diester hydrolases |
| Nucleotidyltransferase | 1 | INHERITED FROM: Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase || Diphosphoric monoester hydrolases |
| TGS-like | 1 | INHERITED FROM: Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase || Diphosphoric monoester hydrolases |
| Inosine monophosphate dehydrogenase (IMPDH) | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Protein-tyrosine-phosphatase |
| Periplasmic binding protein-like II | 1 | INHERITED FROM: Alkaline phosphatase |
| Terpenoid cyclases/Protein prenyltransferases | 1 | INHERITED FROM: Geranyl diphosphate diphosphatase || Diphosphoric monoester hydrolases |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Polynucleotide 3'-phosphatase || ADP-ribose 1''-phosphate phosphatase || Type III site-specific deoxyribonuclease || Polynucleotide 5'-phosphatase || Fructose-2,6-bisphosphate 2-phosphatase || Exodeoxyribonuclease V || Type I site-specific deoxyribonuclease |
| beta-lactamase/transpeptidase-like | 1 | INHERITED FROM: Teichoic acid D-alanine hydrolase |
| DHH phosphoesterases | 1 | INHERITED FROM: Phosphoric diester hydrolases || 3'(2'),5'-bisphosphate nucleotidase || Cyclic-di-AMP phosphodiesterase |
| Cysteine proteinases | 1 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| GroES-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Exoribonuclease II || Ribonuclease E |
| Macro domain-like | 1 | INHERITED FROM: ADP-ribose 1''-phosphate phosphatase || Phosphoric monoester hydrolases || O-acetyl-ADP-ribose deacetylase || Polynucleotide 5'-phosphatase |
| dUTPase-like | 1 | INHERITED FROM: Retroviral ribonuclease H || Exoribonuclease H || Exoribonucleases producing 5'-phosphomonoesters || Endoribonucleases producing 5'-phosphomonoesters |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || ADP-ribose 1''-phosphate phosphatase || Polynucleotide 5'-phosphatase |
| PDZ domain-like | 1 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| Thiolase-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Palmitoyl-CoA hydrolase || Thiolester hydrolases || Acetyl-CoA hydrolase |
| ACT-like | 1 | INHERITED FROM: Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase || Phosphoserine phosphatase || Diphosphoric monoester hydrolases |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| Voltage-gated potassium channels | 0 | Direct |
| Ribonuclease H-like | 0 | Direct |
| PAZ domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Peptidyl-tRNA hydrolase-like | 0 | Direct |
| ComB-like | 0 | Direct |
| Nitrous oxide reductase, N-terminal domain | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| Toprim domain | 0 | Direct |
| (Phosphotyrosine protein) phosphatases II | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| GAF domain-like | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| SGNH hydrolase | 0 | Direct |
| Peptidyl-tRNA hydrolase II | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| EAL domain-like | 0 | Direct |
| L9 N-domain-like | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
| Rof/RNase P subunit-like | 0 | Direct |
| CheY-like | 0 | Direct |
| DNase I-like | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Thermostable phytase (3-phytase) | 0 | Direct |
| Phosphotyrosine protein phosphatases I | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Outer membrane phospholipase A (OMPLA) | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Staphylococcal nuclease | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| His-Me finger endonucleases | 0 | Direct |
| Phospholipase A2, PLA2 | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| Phospholipase D/nuclease | 0 | Direct |
| Metallo-dependent phosphatases | 0 | Direct |
| Metallo-hydrolase/oxidoreductase | 0 | Direct |
| Methylesterase CheB, C-terminal domain | 0 | Direct |
| Viral protein domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| PH domain-like | 0 | Direct |
| AlbA-like | 0 | Direct |
| PP2C-like | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Peptidyl-tRNA hydrolase domain-like | 0 | Direct |
| Influenza hemagglutinin (stalk) | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| DTD-like | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| SurE-like | 0 | Direct |
| Holliday junction resolvase RusA | 0 | Direct |
| Microbial ribonucleases | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| AF0625-like | 0 | Direct |
| PHP domain-like | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| HAD-like | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| Bacterial GAP domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| XseB-like | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Phospholipase C/P1 nuclease | 0 | Direct |
| Rnp2-like | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| Plant invertase/pectin methylesterase inhibitor | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| WD40 repeat-like | 0.000000000000001059 | Direct |
| Alkaline phosphatase-like | 0.000000000000002809 | Direct |
| LigT-like | 0.000000000000008551 | Direct |
| Fibronectin type III | 0.00000000000002957 | Direct |
| EF-hand | 0.0000000000001006 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000005154 | Direct |
| PIN domain-like | 0.0000000003167 | Direct |
| DEK C-terminal domain | 0.000000001795 | Direct |
| DNA clamp | 0.000000003538 | Direct |
| SMAD/FHA domain | 0.00000002074 | Direct |
| PX domain | 0.00000008526 | Direct |
| Second domain of FERM | 0.0000001336 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0.0000004689 | Direct |
| L domain-like | 0.0000009439 | Direct |
| SH2 domain | 0.000002113 | Direct |
| Restriction endonuclease-like | 0.000003005 | Direct |
| GTPase activation domain, GAP | 0.000003999 | Direct |
| Integrin alpha N-terminal domain | 0.000003999 | Direct |
| Ras GEF | 0.000005358 | Direct |
| Saposin | 0.000006809 | Direct |
| Acid proteases | 0.00003183 | Direct |
| Immunoglobulin | 0.00004162 | Direct |
| C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | 0.00004392 | Direct |
| ssDNA viruses | 0.00007515 | Direct |
| Chaperone J-domain | 0.0002059 | Direct |
| CYTH-like phosphatases | 0.0007645 | Direct |
| NTF2-like | 0.001543 | Inherited |
| CRAL/TRIO domain | 0.002304 | Inherited |
| HRDC-like | 0.005222 | Inherited |
| Pectin lyase-like | 0.009007 | Inherited |
| RNA-binding domain, RBD | 0.01492 | Inherited |
| Kelch motif | 0.01835 | Inherited |
| Non-globular alpha+beta subunits of globular proteins | 0.02223 | Inherited |
| Ubiquitin-like | 0.05491 | Inherited |
| L30e-like | 0.0675 | Inherited |
| R3H domain | 0.1002 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1969 | Inherited |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2031 | Inherited |
| Bet v1-like | 0.2164 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.2255 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.2714 | Inherited |
| Hedgehog/intein (Hint) domain | 0.2891 | Inherited |
| Autotransporter | 0.2895 | Inherited |
| ACP-like | 0.2997 | Inherited |
| Carbonic anhydrase | 0.3413 | Inherited |
| FYVE/PHD zinc finger | 0.369 | Inherited |
| Ankyrin repeat | 0.3725 | Inherited |
| SH3-domain | 0.436 | Inherited |
| SAM/Pointed domain | 0.455 | Inherited |
| TPR-like | 0.5971 | Inherited |
| Starch-binding domain-like | 0.6913 | Inherited |
| HIT-like | 0.8877 | Inherited |
| Tudor/PWWP/MBT | 0.8894 | Inherited |
| AraD/HMP-PK domain-like | 0.9316 | Inherited |
| Glutaminase/Asparaginase | 1 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
| Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| Terpenoid synthases | 1 | Inherited |
| Glycoside hydrolase/deacetylase | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| Nucleotide cyclase | 1 | Inherited |
| Nucleotidyltransferase | 1 | Inherited |
| TGS-like | 1 | Inherited |
| Inosine monophosphate dehydrogenase (IMPDH) | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
| Periplasmic binding protein-like II | 1 | Inherited |
| Terpenoid cyclases/Protein prenyltransferases | 1 | Inherited |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| beta-lactamase/transpeptidase-like | 1 | Inherited |
| DHH phosphoesterases | 1 | Inherited |
| Cysteine proteinases | 1 | Inherited |
| GroES-like | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| Macro domain-like | 1 | Inherited |
| dUTPase-like | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| ACT-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56784,54427
56784 - HAD-like
54427 - NTF2-like | 0 | DIRECT |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | DIRECT |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
53098,54928
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
56219,56219
56219 - DNase I-like
56219 - DNase I-like | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
101908,56219
101908 - Putative isomerase YbhE
56219 - DNase I-like | 0 | DIRECT |
56784,52540
56784 - HAD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0 | DIRECT |
49562,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like | 0 | DIRECT |
47819,47819
47819 - HRDC-like
47819 - HRDC-like | 0 | DIRECT |
52087,52799
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
53098,53098
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
50974,50974
50974 - Nitrous oxide reductase, N-terminal domain
50974 - Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
52799,56091
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
56568,47233
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain | 0 | DIRECT |
48452,56300
48452 - TPR-like
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
51695,51695
51695 - PLC-like phosphodiesterases
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
50249,56300
50249 - Nucleic acid-binding proteins
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
56672,46919
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
81324,52799
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
55658,53098
55658 - L9 N-domain-like
53098 - Ribonuclease H-like | 0 | DIRECT |
51069,49265
51069 - Carbonic anhydrase
49265 - Fibronectin type III | 0 | DIRECT |
69065,69065
69065 - RNase III domain-like
69065 - RNase III domain-like | 0 | DIRECT |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
53098,47819
53098 - Ribonuclease H-like
47819 - HRDC-like | 0 | DIRECT |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
53098,51283
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | DIRECT |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
49363,56300
49363 - Purple acid phosphatase, N-terminal domain
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
50044,51695
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50199,63748
50199 - Staphylococcal nuclease
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
49562,52151
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52266,49818
52266 - SGNH hydrolase
49818 - Viral protein domain | 0 | DIRECT |
82708,53098
82708 - R3H domain
53098 - Ribonuclease H-like | 0 | DIRECT |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
56300,47473
56300 - Metallo-dependent phosphatases
47473 - EF-hand | 0 | DIRECT |
51283,46919
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
52151,52151
52151 - FabD/lysophospholipase-like
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
52266,103515
52266 - SGNH hydrolase
103515 - Autotransporter | 0 | DIRECT |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | DIRECT |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
52058,56219
52058 - L domain-like
56219 - DNase I-like | 0 | DIRECT |
49562,56024
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
56024 - Phospholipase D/nuclease | 0 | DIRECT |
47233,52799
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
50156,52799
50156 - PDZ domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
53649,54060
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | DIRECT |
56784,53474
56784 - HAD-like
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
56784,56784
56784 - HAD-like
56784 - HAD-like | 0 | DIRECT |
52172,52738
52172 - CheY-like
52738 - Methylesterase CheB, C-terminal domain | 0 | DIRECT |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
55550,52799
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
56300,56300
56300 - Metallo-dependent phosphatases
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
50729,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | DIRECT |
101148,51126
101148 - Plant invertase/pectin methylesterase inhibitor
51126 - Pectin lyase-like | 0 | DIRECT |
49879,54197
49879 - SMAD/FHA domain
54197 - HIT-like | 0 | DIRECT |
56219,54928
56219 - DNase I-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
49452,52799
49452 - Starch-binding domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
50199,50199
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease | 0 | DIRECT |
54001,53098
54001 - Cysteine proteinases
53098 - Ribonuclease H-like | 0 | DIRECT |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
48537,49723
48537 - Phospholipase C/P1 nuclease
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
109715,52799
109715 - DEK C-terminal domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
50729,52799
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
54236,56784
54236 - Ubiquitin-like
56784 - HAD-like | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52540,55144
52540 - P-loop containing nucleoside triphosphate hydrolases
55144 - LigT-like | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.000000000000001235 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000000000000005248 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00000000000001565 | DIRECT |
64268,50729
64268 - PX domain
50729 - PH domain-like | 0.000000000013 | DIRECT |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0.00000000004026 | DIRECT |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000005154 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.0000000004055 | DIRECT |
55073,141868
55073 - Nucleotide cyclase
141868 - EAL domain-like | 0.000000003538 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.00000001111 | DIRECT |
63748,50199
63748 - Tudor/PWWP/MBT
50199 - Staphylococcal nuclease | 0.00000002631 | DIRECT |
56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0.00000004721 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.0000007748 | DIRECT |
81301,81271
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.00000476 | DIRECT |
109604,81301
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase | 0.000004885 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000009394 | DIRECT |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0.00007515 | DIRECT |
53474,53335
53474 - alpha/beta-Hydrolases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.0002059 | DIRECT |
53756,56784
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56784 - HAD-like | 0.001679 | INHERITED FROM: Phosphoric monoester hydrolases || Trehalose-phosphatase |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.002304 | INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C |
53774,48403
53774 - Glutaminase/Asparaginase
48403 - Ankyrin repeat | 0.0091 | INHERITED FROM: 1-alkyl-2-acetylglycerophosphocholine esterase || Lysophospholipase || Carboxylic ester hydrolases |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.01122 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
57756,51283
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.0164 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
51283,50630
51283 - dUTPase-like
50630 - Acid proteases | 0.0164 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.02085 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0456 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.05496 | INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.127 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1969 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0.223 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Endodeoxyribonucleases producing 5'-phosphomonoesters || Type III site-specific deoxyribonuclease || Exodeoxyribonuclease V || Type I site-specific deoxyribonuclease |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Phosphoric monoester hydrolases || Histidinol-phosphatase |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 1 | INHERITED FROM: Palmitoyl-CoA hydrolase || Acetyl-CoA hydrolase |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 1 | INHERITED FROM: Geranyl diphosphate diphosphatase || Diphosphoric monoester hydrolases |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56784,54427
56784 - HAD-like
54427 - NTF2-like | 0 | Direct |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | Direct |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
53098,54928
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | Direct |
54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
56219,56219
56219 - DNase I-like
56219 - DNase I-like | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
101908,56219
101908 - Putative isomerase YbhE
56219 - DNase I-like | 0 | Direct |
56784,52540
56784 - HAD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0 | Direct |
49562,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like | 0 | Direct |
47819,47819
47819 - HRDC-like
47819 - HRDC-like | 0 | Direct |
52087,52799
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
53098,53098
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
50974,50974
50974 - Nitrous oxide reductase, N-terminal domain
50974 - Nitrous oxide reductase, N-terminal domain | 0 | Direct |
52799,56091
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
56568,47233
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain | 0 | Direct |
48452,56300
48452 - TPR-like
56300 - Metallo-dependent phosphatases | 0 | Direct |
51695,51695
51695 - PLC-like phosphodiesterases
51695 - PLC-like phosphodiesterases | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
50249,56300
50249 - Nucleic acid-binding proteins
56300 - Metallo-dependent phosphatases | 0 | Direct |
56672,46919
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
81324,52799
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
55658,53098
55658 - L9 N-domain-like
53098 - Ribonuclease H-like | 0 | Direct |
51069,49265
51069 - Carbonic anhydrase
49265 - Fibronectin type III | 0 | Direct |
69065,69065
69065 - RNase III domain-like
69065 - RNase III domain-like | 0 | Direct |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
53098,47819
53098 - Ribonuclease H-like
47819 - HRDC-like | 0 | Direct |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
53098,51283
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | Direct |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
49363,56300
49363 - Purple acid phosphatase, N-terminal domain
56300 - Metallo-dependent phosphatases | 0 | Direct |
50044,51695
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | Direct |
50199,63748
50199 - Staphylococcal nuclease
63748 - Tudor/PWWP/MBT | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
49562,52151
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
52151 - FabD/lysophospholipase-like | 0 | Direct |
52266,49818
52266 - SGNH hydrolase
49818 - Viral protein domain | 0 | Direct |
82708,53098
82708 - R3H domain
53098 - Ribonuclease H-like | 0 | Direct |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
56300,47473
56300 - Metallo-dependent phosphatases
47473 - EF-hand | 0 | Direct |
51283,46919
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
52151,52151
52151 - FabD/lysophospholipase-like
52151 - FabD/lysophospholipase-like | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
52266,103515
52266 - SGNH hydrolase
103515 - Autotransporter | 0 | Direct |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | Direct |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
52058,56219
52058 - L domain-like
56219 - DNase I-like | 0 | Direct |
49562,56024
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
56024 - Phospholipase D/nuclease | 0 | Direct |
47233,52799
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
50156,52799
50156 - PDZ domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
53649,54060
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | Direct |
56784,53474
56784 - HAD-like
53474 - alpha/beta-Hydrolases | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
56784,56784
56784 - HAD-like
56784 - HAD-like | 0 | Direct |
52172,52738
52172 - CheY-like
52738 - Methylesterase CheB, C-terminal domain | 0 | Direct |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
55550,52799
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
56300,56300
56300 - Metallo-dependent phosphatases
56300 - Metallo-dependent phosphatases | 0 | Direct |
50729,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | Direct |
101148,51126
101148 - Plant invertase/pectin methylesterase inhibitor
51126 - Pectin lyase-like | 0 | Direct |
49879,54197
49879 - SMAD/FHA domain
54197 - HIT-like | 0 | Direct |
56219,54928
56219 - DNase I-like
54928 - RNA-binding domain, RBD | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
49452,52799
49452 - Starch-binding domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
50199,50199
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease | 0 | Direct |
54001,53098
54001 - Cysteine proteinases
53098 - Ribonuclease H-like | 0 | Direct |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
48537,49723
48537 - Phospholipase C/P1 nuclease
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
109715,52799
109715 - DEK C-terminal domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
50729,52799
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
54236,56784
54236 - Ubiquitin-like
56784 - HAD-like | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
52540,55144
52540 - P-loop containing nucleoside triphosphate hydrolases
55144 - LigT-like | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.000000000000001235 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000000000000005248 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00000000000001565 | Direct |
64268,50729
64268 - PX domain
50729 - PH domain-like | 0.000000000013 | Direct |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0.00000000004026 | Direct |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000005154 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.0000000004055 | Direct |
55073,141868
55073 - Nucleotide cyclase
141868 - EAL domain-like | 0.000000003538 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.00000001111 | Direct |
63748,50199
63748 - Tudor/PWWP/MBT
50199 - Staphylococcal nuclease | 0.00000002631 | Direct |
56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0.00000004721 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.0000007748 | Direct |
81301,81271
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.00000476 | Direct |
109604,81301
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase | 0.000004885 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000009394 | Direct |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0.00007515 | Direct |
53474,53335
53474 - alpha/beta-Hydrolases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.0002059 | Direct |
53756,56784
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56784 - HAD-like | 0.001679 | Inherited |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.002304 | Inherited |
53774,48403
53774 - Glutaminase/Asparaginase
48403 - Ankyrin repeat | 0.0091 | Inherited |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.01122 | Inherited |
57756,51283
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.0164 | Inherited |
51283,50630
51283 - dUTPase-like
50630 - Acid proteases | 0.0164 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.02085 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0456 | Inherited |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.05496 | Inherited |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.127 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1969 | Inherited |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0.223 | Inherited |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 1 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 1 | Inherited |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 1 | Inherited |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
90188,53649,54060
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | DIRECT |
54637,54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
50729,56024,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | DIRECT |
82708,53098,54928
82708 - R3H domain
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
51283,46919,53098
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
50630,56672,46919
50630 - Acid proteases
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
49562,54236,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
56672,53098,51283
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | DIRECT |
55550,55550,50044
55550 - SH2 domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
50199,63748,50199
50199 - Staphylococcal nuclease
63748 - Tudor/PWWP/MBT
50199 - Staphylococcal nuclease | 0 | DIRECT |
56568,47233,52799
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
64268,50729,56024
64268 - PX domain
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | DIRECT |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
55550,55550,52799
55550 - SH2 domain
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
50044,51695,49562
50044 - SH3-domain
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
56672,53098,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
69065,69065,54768
69065 - RNase III domain-like
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
51283,50630,56672
51283 - dUTPase-like
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
56672,53098,50122
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
56672,46919,53098
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
50199,50199,50199
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease | 0 | DIRECT |
53098,51283,46919
53098 - Ribonuclease H-like
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
50199,50199,63748
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
56024,56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | DIRECT |
52799,56091,50249
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | DIRECT |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
55550,50044,51695
55550 - SH2 domain
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
81324,52799,49562
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
46938,52087,52799
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
55781,55781,55781
55781 - GAF domain-like
55781 - GAF domain-like
55781 - GAF domain-like | 0 | DIRECT |
53098,47819,47819
53098 - Ribonuclease H-like
47819 - HRDC-like
47819 - HRDC-like | 0 | DIRECT |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.00000000000001599 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.0000000004055 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.000000009609 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000005825 | DIRECT |
109604,81301,81271
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.00000476 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0003669 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.004255 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.01385 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
57756,51283,50630
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like
50630 - Acid proteases | 0.0164 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
57756,57756,51283
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.02762 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
47353,57756,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.02762 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
90188,53649,54060
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | Direct |
54637,54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
50729,56024,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | Direct |
82708,53098,54928
82708 - R3H domain
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | Direct |
51283,46919,53098
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
50630,56672,46919
50630 - Acid proteases
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
49562,54236,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
56672,53098,51283
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | Direct |
55550,55550,50044
55550 - SH2 domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
50199,63748,50199
50199 - Staphylococcal nuclease
63748 - Tudor/PWWP/MBT
50199 - Staphylococcal nuclease | 0 | Direct |
56568,47233,52799
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
64268,50729,56024
64268 - PX domain
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | Direct |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
55550,55550,52799
55550 - SH2 domain
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
50044,51695,49562
50044 - SH3-domain
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
56672,53098,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
69065,69065,54768
69065 - RNase III domain-like
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
51283,50630,56672
51283 - dUTPase-like
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
56672,53098,50122
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
56672,46919,53098
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
50199,50199,50199
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease | 0 | Direct |
53098,51283,46919
53098 - Ribonuclease H-like
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
50199,50199,63748
50199 - Staphylococcal nuclease
50199 - Staphylococcal nuclease
63748 - Tudor/PWWP/MBT | 0 | Direct |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
56024,56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | Direct |
52799,56091,50249
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | Direct |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
55550,50044,51695
55550 - SH2 domain
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | Direct |
81324,52799,49562
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
46938,52087,52799
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
55781,55781,55781
55781 - GAF domain-like
55781 - GAF domain-like
55781 - GAF domain-like | 0 | Direct |
53098,47819,47819
53098 - Ribonuclease H-like
47819 - HRDC-like
47819 - HRDC-like | 0 | Direct |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.00000000000001599 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.0000000004055 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.000000009609 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000005825 | Direct |
109604,81301,81271
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.00000476 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0003669 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.004255 | Inherited |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.01385 | Inherited |
57756,51283,50630
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like
50630 - Acid proteases | 0.0164 | Inherited |
57756,57756,51283
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.02762 | Inherited |
47353,57756,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.02762 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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