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Enzyme Commission (EC): Acting on peptide bonds (peptidases)
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cap-Gly domain | 0 | DIRECT |
| D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
| Cysteine proteinases | 0 | DIRECT |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | DIRECT |
| "Winged helix" DNA-binding domain | 0 | DIRECT |
| Zn-dependent exopeptidases | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| STI-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Positive stranded ssRNA viruses | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Replicase NSP9 | 0 | DIRECT |
| EndoU-like | 0 | DIRECT |
| Sortase | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| OMPT-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Peptidase/esterase 'gauge' domain | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| LexA/Signal peptidase | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| E set domains | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| Acid proteases | 0 | DIRECT |
| Macro domain-like | 0 | DIRECT |
| Coronavirus NSP10-like | 0 | DIRECT |
| Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Sec-C motif | 0 | DIRECT |
| Coronavirus NSP8-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| SEA domain | 0 | DIRECT |
| PDZ domain-like | 0 | DIRECT |
| HybD-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| SARS Nsp1-like | 0 | DIRECT |
| Aminopeptidase/glucanase lid domain | 0 | DIRECT |
| EGF/Laminin | 0 | DIRECT |
| Penicillin binding protein dimerisation domain | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| LD-carboxypeptidase A C-terminal domain-like | 0 | DIRECT |
| Collagen-binding domain | 0 | DIRECT |
| NSP3A-like | 0 | DIRECT |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Coronavirus NSP7-like | 0 | DIRECT |
| Penicillin-binding protein associated domain | 0 | DIRECT |
| TMV-like viral coat proteins | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Herpes virus serine proteinase, assemblin | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Ubiquitin-like | 2.574e-16 | DIRECT |
| SRCR-like | 0.0000000000009368 | DIRECT |
| HIT/MYND zinc finger-like | 0.000000000005555 | DIRECT |
| TRAF domain-like | 0.00000000001824 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0.00000000005609 | DIRECT |
| FnI-like domain | 0.00000000006555 | DIRECT |
| UBA-like | 0.0000000001899 | DIRECT |
| beta-Roll | 0.000000001853 | DIRECT |
| Duplicated hybrid motif | 0.000000003285 | DIRECT |
| Ran binding protein zinc finger-like | 0.0000002456 | DIRECT |
| EF-hand | 0.0000004827 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0.000002407 | DIRECT |
| beta-lactamase/transpeptidase-like | 0.000004333 | DIRECT |
| PKD domain | 0.000006162 | DIRECT |
| Growth factor receptor domain | 0.00001163 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0.00004417 | DIRECT |
| Autotransporter | 0.0001505 | DIRECT |
| JAB1/MPN domain | 0.001162 | INHERITED FROM: Omega peptidases |
| RING/U-box | 0.004376 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| HSP20-like chaperones | 0.006651 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Ribonuclease Rh-like | 0.007929 | INHERITED FROM: Pestivirus NS3 polyprotein peptidase || Serine endopeptidases |
| ARM repeat | 0.01301 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 || Aminopeptidase B |
| vWA-like | 0.02304 | INHERITED FROM: Alternative-complement-pathway C3/C5 convertase || Classical-complement-pathway C3/C5 convertase || Serine endopeptidases |
| Galactose-binding domain-like | 0.043 | INHERITED FROM: Proprotein convertase 2 || Proprotein convertase 1 || Xaa-Pro dipeptidyl-peptidase || Furin || Dipeptidyl-peptidases and tripeptidyl-peptidases |
| Rhodanese/Cell cycle control phosphatase | 0.6086 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Lysozyme-like | 0.9475 | INHERITED FROM: Serine-type carboxypeptidases || Serine-type D-Ala-D-Ala carboxypeptidase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Dipeptidases || Membrane dipeptidase |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Meprin B || Enteropeptidase || Metalloendopeptidases || Meprin A || Bontoxilysin |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Flavivirin || SARS coronavirus main proteinase || Endothelin-converting enzyme 1 |
| Ribonuclease H-like | 1 | INHERITED FROM: Aspartic endopeptidases || HIV-1 retropepsin || HIV-2 retropepsin |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Dipeptidase E || Cyanophycinase || Peptidyl-dipeptidases || Muramoyltetrapeptide carboxypeptidase || Folate gamma-glutamyl hydrolase || Glucosinolate gamma-glutamyl hydrolase || Dipeptidases |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Pestivirus NS3 polyprotein peptidase || Flavivirin || Nuclear-inclusion-a endopeptidase || Picornain 3C || Helper-component proteinase || Cysteine endopeptidases || Picornain 2A || Serine endopeptidases || Hepacivirin || Endopeptidase La || Calicivirin |
| Pectin lyase-like | 1 | INHERITED FROM: IgA-specific serine endopeptidase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cap-Gly domain | 0 | Direct |
| D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
| Cysteine proteinases | 0 | Direct |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | Direct |
| "Winged helix" DNA-binding domain | 0 | Direct |
| Zn-dependent exopeptidases | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| Kringle-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Hairpin loop containing domain-like | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| PA domain | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| STI-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Positive stranded ssRNA viruses | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Replicase NSP9 | 0 | Direct |
| EndoU-like | 0 | Direct |
| Sortase | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Caspase-like | 0 | Direct |
| OMPT-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| Peptidase/esterase 'gauge' domain | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| LexA/Signal peptidase | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| DUSP-like | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| E set domains | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| Acid proteases | 0 | Direct |
| Macro domain-like | 0 | Direct |
| Coronavirus NSP10-like | 0 | Direct |
| Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Sec-C motif | 0 | Direct |
| Coronavirus NSP8-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| SEA domain | 0 | Direct |
| PDZ domain-like | 0 | Direct |
| HybD-like | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| SARS Nsp1-like | 0 | Direct |
| Aminopeptidase/glucanase lid domain | 0 | Direct |
| EGF/Laminin | 0 | Direct |
| Penicillin binding protein dimerisation domain | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| LD-carboxypeptidase A C-terminal domain-like | 0 | Direct |
| Collagen-binding domain | 0 | Direct |
| NSP3A-like | 0 | Direct |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Coronavirus NSP7-like | 0 | Direct |
| Penicillin-binding protein associated domain | 0 | Direct |
| TMV-like viral coat proteins | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Herpes virus serine proteinase, assemblin | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| PGBD-like | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Ubiquitin-like | 2.574e-16 | Direct |
| SRCR-like | 0.0000000000009368 | Direct |
| HIT/MYND zinc finger-like | 0.000000000005555 | Direct |
| TRAF domain-like | 0.00000000001824 | Direct |
| LuxS/MPP-like metallohydrolase | 0.00000000005609 | Direct |
| FnI-like domain | 0.00000000006555 | Direct |
| UBA-like | 0.0000000001899 | Direct |
| beta-Roll | 0.000000001853 | Direct |
| Duplicated hybrid motif | 0.000000003285 | Direct |
| Ran binding protein zinc finger-like | 0.0000002456 | Direct |
| EF-hand | 0.0000004827 | Direct |
| Bacterial exopeptidase dimerisation domain | 0.000002407 | Direct |
| beta-lactamase/transpeptidase-like | 0.000004333 | Direct |
| PKD domain | 0.000006162 | Direct |
| Growth factor receptor domain | 0.00001163 | Direct |
| Ribosomal protein S5 domain 2-like | 0.00004417 | Direct |
| Autotransporter | 0.0001505 | Direct |
| JAB1/MPN domain | 0.001162 | Inherited |
| RING/U-box | 0.004376 | Inherited |
| HSP20-like chaperones | 0.006651 | Inherited |
| Ribonuclease Rh-like | 0.007929 | Inherited |
| ARM repeat | 0.01301 | Inherited |
| vWA-like | 0.02304 | Inherited |
| Galactose-binding domain-like | 0.043 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.6086 | Inherited |
| Lysozyme-like | 0.9475 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Pectin lyase-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Fibronectin type I module | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | DIRECT |
| M48USP-like | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Germination protease | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Dac-like | 0 | DIRECT |
| Thermolysin-like | 0 | DIRECT |
| Viral proteases | 0 | DIRECT |
| PepX catalytic domain-like | 0 | DIRECT |
| TNF-alpha converting enzyme, TACE, catalytic domain | 0 | DIRECT |
| TMV-like viral coat proteins | 0 | DIRECT |
| Viral cysteine protease of trypsin fold | 0 | DIRECT |
| HtrA-like serine proteases | 0 | DIRECT |
| Leukotriene A4 hydrolase catalytic domain | 0 | DIRECT |
| Fibronectin type II module | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| Papain-like | 0 | DIRECT |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
| NSP3A-like | 0 | DIRECT |
| Staphopain B, prodomain | 0 | DIRECT |
| Tail specific protease, catalytic domain | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| Clostridium neurotoxins, C-terminal domain | 0 | DIRECT |
| PKD domain | 0 | DIRECT |
| SEA domain | 0 | DIRECT |
| Serralysin-like metalloprotease, catalytic (N-terminal) domain | 0 | DIRECT |
| Type 1 signal peptidase | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| PBP transglycosylase domain-like | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| FMDV leader protease | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| RNA helicase | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Carboxypeptidase T | 0 | DIRECT |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | DIRECT |
| LexA-related | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| Nsp15 N-terminal domain-like | 0 | DIRECT |
| Retrovirus capsid protein C-terminal domain | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Coronavirus NSP7-like | 0 | DIRECT |
| LD-carboxypeptidase A N-terminal domain-like | 0 | DIRECT |
| Penta-EF-hand proteins | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | DIRECT |
| Hepsin, N-terminal domain | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| Proline iminopeptidase-like | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Gingipain R (RgpB), N-terminal domain | 0 | DIRECT |
| Leucine aminopeptidase (Aminopeptidase A), N-terminal domain | 0 | DIRECT |
| Class II viral fusion proteins C-terminal domain | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| SARS Nsp1-like | 0 | DIRECT |
| Serine-carboxyl proteinase, SCP | 0 | DIRECT |
| Eukaryotic proteases | 0 | DIRECT |
| LexA repressor, N-terminal DNA-binding domain | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| Caspase recruitment domain, CARD | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Virulence factor P.69 pertactin | 0 | DIRECT |
| Immunodeficiency virus matrix proteins | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Caliciviridae-like VP | 0 | DIRECT |
| Leishmanolysin | 0 | DIRECT |
| Prolyl oligopeptidase, N-terminal domain | 0 | DIRECT |
| Outer membrane protease OMPT | 0 | DIRECT |
| PBP5 C-terminal domain-like | 0 | DIRECT |
| Nsp15 C-terminal domain-like | 0 | DIRECT |
| Coronavirus NSP10-like | 0 | DIRECT |
| Aminopeptidase/glucanase lid domain | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| LD-carboxypeptidase A C-terminal domain-like | 0 | DIRECT |
| beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
| Clostridium neurotoxins, catalytic domain | 0 | DIRECT |
| Gingipain R (RgpB), C-terminal domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Leucine aminopeptidase, C-terminal domain | 0 | DIRECT |
| NlpC/P60 | 0 | DIRECT |
| Zinc protease | 0 | DIRECT |
| MMP N-terminal domain | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Nodaviridae-like VP | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Coronavirus NSP8-like | 0 | DIRECT |
| Clp protease, ClpP subunit | 0 | DIRECT |
| EGF-type module | 0 | DIRECT |
| Fungal zinc peptidase | 0 | DIRECT |
| Integrin A (or I) domain | 0 | DIRECT |
| D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Herpes virus serine proteinase, assemblin | 0 | DIRECT |
| Sortase | 0 | DIRECT |
| Clostridium neurotoxins, the second last domain | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| Renal dipeptidase | 0 | DIRECT |
| Sec-C motif | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| PepX C-terminal domain-like | 0 | DIRECT |
| Astacin | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| Ubiquitin thiolesterase protein OTUB2 (Otubain-2) | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| VanX-like | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Retroviral protease (retropepsin) | 0 | DIRECT |
| MATH domain | 0 | DIRECT |
| mRNA cap methylase | 0 | DIRECT |
| Collagen-binding domain | 0 | DIRECT |
| RNA-dependent RNA-polymerase | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| Subtilase propeptides/inhibitors | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| Neurolysin-like | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Prokaryotic proteases | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Prolyl oligopeptidase, C-terminal domain | 0 | DIRECT |
| Penicillin binding protein dimerisation domain | 0 | DIRECT |
| Replicase NSP9 | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Aspartyl dipeptidase PepE | 0 | DIRECT |
| Kringle modules | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0.000000000000003816 | DIRECT |
| Peptidoglycan hydrolase LytM | 0.000000000000137 | DIRECT |
| Reverse transcriptase | 0.000000000000243 | DIRECT |
| Bacterial dinuclear zinc exopeptidases | 0.0000000002061 | DIRECT |
| MYND zinc finger | 0.0000000007836 | DIRECT |
| Macro domain | 0.000000001016 | DIRECT |
| Serralysin-like metalloprotease, C-terminal domain | 0.000000002447 | DIRECT |
| Retroviral integrase, catalytic domain | 0.00000001523 | DIRECT |
| UBA domain | 0.00000007353 | DIRECT |
| (Glycosyl)asparaginase | 0.0000001301 | DIRECT |
| Ran binding protein zinc finger-like | 0.00000031 | DIRECT |
| Anthrax toxin lethal factor, N- and C-terminal domains | 0.000002095 | DIRECT |
| GS domain | 0.000002095 | DIRECT |
| Ubiquitin-related | 0.000002598 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0.00001987 | DIRECT |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.00004555 | DIRECT |
| MAM domain | 0.000208 | DIRECT |
| Growth factor receptor domain | 0.001322 | INHERITED FROM: Furin || Serine endopeptidases |
| Ribonuclease Rh-like | 0.008827 | INHERITED FROM: Pestivirus NS3 polyprotein peptidase || Serine endopeptidases |
| Extended AAA-ATPase domain | 0.1306 | INHERITED FROM: Serine endopeptidases || Endopeptidase La |
| Leukotriene A4 hydrolase C-terminal domain | 0.7349 | INHERITED FROM: Aminopeptidase B || Aminopeptidases |
| Ribonuclease H | 1 | INHERITED FROM: Aspartic endopeptidases || HIV-1 retropepsin || HIV-2 retropepsin |
| Class I glutamine amidotransferases (GAT) | 1 | INHERITED FROM: Folate gamma-glutamyl hydrolase || Glucosinolate gamma-glutamyl hydrolase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Fibronectin type I module | 0 | Direct |
| Zf-UBP | 0 | Direct |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | Direct |
| M48USP-like | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Germination protease | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Dac-like | 0 | Direct |
| Thermolysin-like | 0 | Direct |
| Viral proteases | 0 | Direct |
| PepX catalytic domain-like | 0 | Direct |
| TNF-alpha converting enzyme, TACE, catalytic domain | 0 | Direct |
| TMV-like viral coat proteins | 0 | Direct |
| Viral cysteine protease of trypsin fold | 0 | Direct |
| HtrA-like serine proteases | 0 | Direct |
| Leukotriene A4 hydrolase catalytic domain | 0 | Direct |
| Fibronectin type II module | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| Papain-like | 0 | Direct |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
| NSP3A-like | 0 | Direct |
| Staphopain B, prodomain | 0 | Direct |
| Tail specific protease, catalytic domain | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| Clostridium neurotoxins, C-terminal domain | 0 | Direct |
| PKD domain | 0 | Direct |
| SEA domain | 0 | Direct |
| Serralysin-like metalloprotease, catalytic (N-terminal) domain | 0 | Direct |
| Type 1 signal peptidase | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| PBP transglycosylase domain-like | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| FMDV leader protease | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| RNA helicase | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Carboxypeptidase T | 0 | Direct |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | Direct |
| LexA-related | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| Nsp15 N-terminal domain-like | 0 | Direct |
| Retrovirus capsid protein C-terminal domain | 0 | Direct |
| Pepsin-like | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Coronavirus NSP7-like | 0 | Direct |
| LD-carboxypeptidase A N-terminal domain-like | 0 | Direct |
| Penta-EF-hand proteins | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | Direct |
| Hepsin, N-terminal domain | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| LON domain-like | 0 | Direct |
| Proline iminopeptidase-like | 0 | Direct |
| Subtilases | 0 | Direct |
| Gingipain R (RgpB), N-terminal domain | 0 | Direct |
| Leucine aminopeptidase (Aminopeptidase A), N-terminal domain | 0 | Direct |
| Class II viral fusion proteins C-terminal domain | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| SARS Nsp1-like | 0 | Direct |
| Serine-carboxyl proteinase, SCP | 0 | Direct |
| Eukaryotic proteases | 0 | Direct |
| LexA repressor, N-terminal DNA-binding domain | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| Caspase recruitment domain, CARD | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Virulence factor P.69 pertactin | 0 | Direct |
| Immunodeficiency virus matrix proteins | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Caliciviridae-like VP | 0 | Direct |
| Leishmanolysin | 0 | Direct |
| Prolyl oligopeptidase, N-terminal domain | 0 | Direct |
| Outer membrane protease OMPT | 0 | Direct |
| PBP5 C-terminal domain-like | 0 | Direct |
| Nsp15 C-terminal domain-like | 0 | Direct |
| Coronavirus NSP10-like | 0 | Direct |
| Aminopeptidase/glucanase lid domain | 0 | Direct |
| Adenain-like | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| LD-carboxypeptidase A C-terminal domain-like | 0 | Direct |
| beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
| Clostridium neurotoxins, catalytic domain | 0 | Direct |
| Gingipain R (RgpB), C-terminal domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Leucine aminopeptidase, C-terminal domain | 0 | Direct |
| NlpC/P60 | 0 | Direct |
| Zinc protease | 0 | Direct |
| MMP N-terminal domain | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Nodaviridae-like VP | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Coronavirus NSP8-like | 0 | Direct |
| Clp protease, ClpP subunit | 0 | Direct |
| EGF-type module | 0 | Direct |
| Fungal zinc peptidase | 0 | Direct |
| Integrin A (or I) domain | 0 | Direct |
| D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Herpes virus serine proteinase, assemblin | 0 | Direct |
| Sortase | 0 | Direct |
| Clostridium neurotoxins, the second last domain | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| Renal dipeptidase | 0 | Direct |
| Sec-C motif | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| PepX C-terminal domain-like | 0 | Direct |
| Astacin | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| Ubiquitin thiolesterase protein OTUB2 (Otubain-2) | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| VanX-like | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Retroviral protease (retropepsin) | 0 | Direct |
| MATH domain | 0 | Direct |
| mRNA cap methylase | 0 | Direct |
| Collagen-binding domain | 0 | Direct |
| RNA-dependent RNA-polymerase | 0 | Direct |
| MPP-like | 0 | Direct |
| Subtilase propeptides/inhibitors | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| Neurolysin-like | 0 | Direct |
| PA domain | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Prokaryotic proteases | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Prolyl oligopeptidase, C-terminal domain | 0 | Direct |
| Penicillin binding protein dimerisation domain | 0 | Direct |
| Replicase NSP9 | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Aspartyl dipeptidase PepE | 0 | Direct |
| Kringle modules | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0.000000000000003816 | Direct |
| Peptidoglycan hydrolase LytM | 0.000000000000137 | Direct |
| Reverse transcriptase | 0.000000000000243 | Direct |
| Bacterial dinuclear zinc exopeptidases | 0.0000000002061 | Direct |
| MYND zinc finger | 0.0000000007836 | Direct |
| Macro domain | 0.000000001016 | Direct |
| Serralysin-like metalloprotease, C-terminal domain | 0.000000002447 | Direct |
| Retroviral integrase, catalytic domain | 0.00000001523 | Direct |
| UBA domain | 0.00000007353 | Direct |
| (Glycosyl)asparaginase | 0.0000001301 | Direct |
| Ran binding protein zinc finger-like | 0.00000031 | Direct |
| Anthrax toxin lethal factor, N- and C-terminal domains | 0.000002095 | Direct |
| GS domain | 0.000002095 | Direct |
| Ubiquitin-related | 0.000002598 | Direct |
| Bacterial exopeptidase dimerisation domain | 0.00001987 | Direct |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.00004555 | Direct |
| MAM domain | 0.000208 | Direct |
| Growth factor receptor domain | 0.001322 | Inherited |
| Ribonuclease Rh-like | 0.008827 | Inherited |
| Extended AAA-ATPase domain | 0.1306 | Inherited |
| Leukotriene A4 hydrolase C-terminal domain | 0.7349 | Inherited |
| Ribonuclease H | 1 | Inherited |
| Class I glutamine amidotransferases (GAT) | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Aminopeptidase/glucanase lid domain | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| "Winged helix" DNA-binding domain | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| LD-carboxypeptidase A C-terminal domain-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| Sec-C motif | 0 | DIRECT |
| Penicillin-binding protein associated domain | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| EGF/Laminin | 0 | DIRECT |
| Penicillin binding protein dimerisation domain | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | DIRECT |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | DIRECT |
| Herpes virus serine proteinase, assemblin | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| SEA domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
| E set domains | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Sortase | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Replicase NSP9 | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Zn-dependent exopeptidases | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Acid proteases | 0 | DIRECT |
| SARS Nsp1-like | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Coronavirus NSP8-like | 0 | DIRECT |
| Coronavirus NSP10-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| TMV-like viral coat proteins | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| EndoU-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Coronavirus NSP7-like | 0 | DIRECT |
| STI-like | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Cysteine proteinases | 0 | DIRECT |
| HybD-like | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| Macro domain-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| LexA/Signal peptidase | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Peptidase/esterase 'gauge' domain | 0 | DIRECT |
| OMPT-like | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| NSP3A-like | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| Positive stranded ssRNA viruses | 0 | DIRECT |
| PDZ domain-like | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Collagen-binding domain | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Ubiquitin-like | 1.78e-16 | DIRECT |
| SRCR-like | 0.0000000000006717 | DIRECT |
| HIT/MYND zinc finger-like | 0.000000000004005 | DIRECT |
| TRAF domain-like | 0.00000000001324 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0.00000000004098 | DIRECT |
| FnI-like domain | 0.00000000004796 | DIRECT |
| UBA-like | 0.0000000001401 | DIRECT |
| beta-Roll | 0.000000001381 | DIRECT |
| Duplicated hybrid motif | 0.000000002463 | DIRECT |
| Ran binding protein zinc finger-like | 0.000000189 | DIRECT |
| EF-hand | 0.0000003735 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0.000001888 | DIRECT |
| beta-lactamase/transpeptidase-like | 0.000003404 | DIRECT |
| PKD domain | 0.000004849 | DIRECT |
| Growth factor receptor domain | 0.000009212 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0.00003534 | DIRECT |
| Autotransporter | 0.0001218 | DIRECT |
| JAB1/MPN domain | 0.0009596 | DIRECT |
| RING/U-box | 0.003666 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| HSP20-like chaperones | 0.005601 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Ribonuclease Rh-like | 0.006693 | INHERITED FROM: Serine endopeptidases || Pestivirus NS3 polyprotein peptidase |
| ARM repeat | 0.01105 | INHERITED FROM: Aminopeptidase B || Omega peptidases || Ubiquitinyl hydrolase 1 |
| vWA-like | 0.01971 | INHERITED FROM: Serine endopeptidases || Classical-complement-pathway C3/C5 convertase || Alternative-complement-pathway C3/C5 convertase |
| Galactose-binding domain-like | 0.03701 | INHERITED FROM: Proprotein convertase 1 || Dipeptidyl-peptidases and tripeptidyl-peptidases || Furin || Xaa-Pro dipeptidyl-peptidase || Proprotein convertase 2 |
| Rhodanese/Cell cycle control phosphatase | 0.5584 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Lysozyme-like | 0.8763 | INHERITED FROM: Serine-type D-Ala-D-Ala carboxypeptidase || Serine-type carboxypeptidases |
| Ribonuclease H-like | 1 | INHERITED FROM: HIV-1 retropepsin || HIV-2 retropepsin || Aspartic endopeptidases |
| Pectin lyase-like | 1 | INHERITED FROM: IgA-specific serine endopeptidase |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Meprin A || Enteropeptidase || Bontoxilysin || Meprin B || Metalloendopeptidases |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Membrane dipeptidase || Dipeptidases |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Picornain 2A || Serine endopeptidases || Hepacivirin || Helper-component proteinase || Endopeptidase La || Cysteine endopeptidases || Pestivirus NS3 polyprotein peptidase || Flavivirin || Calicivirin || Nuclear-inclusion-a endopeptidase || Picornain 3C |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: SARS coronavirus main proteinase || Flavivirin || Endothelin-converting enzyme 1 |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Dipeptidases || Glucosinolate gamma-glutamyl hydrolase || Muramoyltetrapeptide carboxypeptidase || Folate gamma-glutamyl hydrolase || Cyanophycinase || Peptidyl-dipeptidases || Dipeptidase E |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Aminopeptidase/glucanase lid domain | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| "Winged helix" DNA-binding domain | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| PA domain | 0 | Direct |
| DUSP-like | 0 | Direct |
| LD-carboxypeptidase A C-terminal domain-like | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| Sec-C motif | 0 | Direct |
| Penicillin-binding protein associated domain | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| EGF/Laminin | 0 | Direct |
| Penicillin binding protein dimerisation domain | 0 | Direct |
| DEATH domain | 0 | Direct |
| Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | Direct |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | Direct |
| Herpes virus serine proteinase, assemblin | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| SEA domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
| E set domains | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Sortase | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Replicase NSP9 | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Zn-dependent exopeptidases | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Acid proteases | 0 | Direct |
| SARS Nsp1-like | 0 | Direct |
| Kringle-like | 0 | Direct |
| Coronavirus NSP8-like | 0 | Direct |
| Coronavirus NSP10-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| TMV-like viral coat proteins | 0 | Direct |
| Hairpin loop containing domain-like | 0 | Direct |
| EndoU-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Coronavirus NSP7-like | 0 | Direct |
| STI-like | 0 | Direct |
| GLA-domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Cysteine proteinases | 0 | Direct |
| HybD-like | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| Macro domain-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| LexA/Signal peptidase | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Peptidase/esterase 'gauge' domain | 0 | Direct |
| OMPT-like | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| NSP3A-like | 0 | Direct |
| Caspase-like | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| Positive stranded ssRNA viruses | 0 | Direct |
| PDZ domain-like | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Collagen-binding domain | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| PGBD-like | 0 | Direct |
| Ubiquitin-like | 1.78e-16 | Direct |
| SRCR-like | 0.0000000000006717 | Direct |
| HIT/MYND zinc finger-like | 0.000000000004005 | Direct |
| TRAF domain-like | 0.00000000001324 | Direct |
| LuxS/MPP-like metallohydrolase | 0.00000000004098 | Direct |
| FnI-like domain | 0.00000000004796 | Direct |
| UBA-like | 0.0000000001401 | Direct |
| beta-Roll | 0.000000001381 | Direct |
| Duplicated hybrid motif | 0.000000002463 | Direct |
| Ran binding protein zinc finger-like | 0.000000189 | Direct |
| EF-hand | 0.0000003735 | Direct |
| Bacterial exopeptidase dimerisation domain | 0.000001888 | Direct |
| beta-lactamase/transpeptidase-like | 0.000003404 | Direct |
| PKD domain | 0.000004849 | Direct |
| Growth factor receptor domain | 0.000009212 | Direct |
| Ribosomal protein S5 domain 2-like | 0.00003534 | Direct |
| Autotransporter | 0.0001218 | Direct |
| JAB1/MPN domain | 0.0009596 | Direct |
| RING/U-box | 0.003666 | Inherited |
| HSP20-like chaperones | 0.005601 | Inherited |
| Ribonuclease Rh-like | 0.006693 | Inherited |
| ARM repeat | 0.01105 | Inherited |
| vWA-like | 0.01971 | Inherited |
| Galactose-binding domain-like | 0.03701 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.5584 | Inherited |
| Lysozyme-like | 0.8763 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| Pectin lyase-like | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,54001
57850 - RING/U-box
54001 - Cysteine proteinases | 0 | DIRECT |
82671,57424
82671 - SEA domain
57424 - LDL receptor-like module | 0 | DIRECT |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55486,51120
55486 - Metalloproteases ("zincins"), catalytic domain
51120 - beta-Roll | 0 | DIRECT |
49599,54001
49599 - TRAF domain-like
54001 - Cysteine proteinases | 0 | DIRECT |
52743,52025
52743 - Subtilisin-like
52025 - PA domain | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
56601,69189
56601 - beta-lactamase/transpeptidase-like
69189 - Penicillin-binding protein associated domain | 0 | DIRECT |
89043,50494
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | DIRECT |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
100895,56487
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like | 0 | DIRECT |
49854,49854
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
81761,53474
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
54001,46934
54001 - Cysteine proteinases
46934 - UBA-like | 0 | DIRECT |
56519,56601
56519 - Penicillin binding protein dimerisation domain
56601 - beta-lactamase/transpeptidase-like | 0 | DIRECT |
101821,53187
101821 - Aminopeptidase/glucanase lid domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
53092,55920
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | DIRECT |
53092,53092
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
54403,54001
54403 - Cystatin/monellin
54001 - Cysteine proteinases | 0 | DIRECT |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | DIRECT |
57603,57440
57603 - FnI-like domain
57440 - Kringle-like | 0 | DIRECT |
50156,52096
50156 - PDZ domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
50494,56672
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
53300,50494
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
49899,50386
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | DIRECT |
89260,89260
89260 - Collagen-binding domain
89260 - Collagen-binding domain | 0 | DIRECT |
75001,54001
75001 - Dipeptidyl peptidase I (cathepsin C), exclusion domain
54001 - Cysteine proteinases | 0 | DIRECT |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
52949,53187
52949 - Macro domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
58091,49899
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
140367,143076
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like | 0 | DIRECT |
57424,49854
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49854,50494
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
52129,81296
52129 - Caspase-like
81296 - E set domains | 0 | DIRECT |
50886,50886
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
103642,55920
103642 - Sec-C motif
55920 - Creatinase/aminopeptidase | 0 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
56601,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
49854,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
82671,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
46785,51306
46785 - "Winged helix" DNA-binding domain
51306 - LexA/Signal peptidase | 0 | DIRECT |
57184,50494
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55486,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | DIRECT |
159936,52949
159936 - NSP3A-like
52949 - Macro domain-like | 0 | DIRECT |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
49299,89260
49299 - PKD domain
89260 - Collagen-binding domain | 0 | DIRECT |
57535,53300
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | DIRECT |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | DIRECT |
49899,49854
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | DIRECT |
54001,55205
54001 - Cysteine proteinases
55205 - EPT/RTPC-like | 0 | DIRECT |
56487,57424
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | DIRECT |
57440,57196
57440 - Kringle-like
57196 - EGF/Laminin | 0 | DIRECT |
52317,141986
52317 - Class I glutamine amidotransferase-like
141986 - LD-carboxypeptidase A C-terminal domain-like | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
143076,101816
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | DIRECT |
49899,49599
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | DIRECT |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | DIRECT |
143791,54236
143791 - DUSP-like
54236 - Ubiquitin-like | 0 | DIRECT |
57630,57440
57630 - GLA-domain
57440 - Kringle-like | 0 | DIRECT |
53474,49785
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
55486,58091
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
53955,56601
53955 - Lysozyme-like
56601 - beta-lactamase/transpeptidase-like | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
88633,50494
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
101816,144246
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | DIRECT |
74924,54001
74924 - Cap-Gly domain
54001 - Cysteine proteinases | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
49854,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | DIRECT |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
56487,50494
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
55486,49899
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53335,142877
53335 - S-adenosyl-L-methionine-dependent methyltransferases
142877 - EndoU-like | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,54211
52540 - P-loop containing nucleoside triphosphate hydrolases
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57630,57184
57630 - GLA-domain
57184 - Growth factor receptor domain | 0 | DIRECT |
54001,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
55486,82895
55486 - Metalloproteases ("zincins"), catalytic domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57424,56487
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
48371,54001
48371 - ARM repeat
54001 - Cysteine proteinases | 0 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54236,54001
54236 - Ubiquitin-like
54001 - Cysteine proteinases | 0 | DIRECT |
49854,49899
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,89043
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
54001,144232
54001 - Cysteine proteinases
144232 - HIT/MYND zinc finger-like | 0 | DIRECT |
88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
50993,53474
50993 - Peptidase/esterase 'gauge' domain
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
49464,53187
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | DIRECT |
159936,53335
159936 - NSP3A-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
143791,143791
143791 - DUSP-like
143791 - DUSP-like | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 1.78e-16 | DIRECT |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 3.548e-16 | DIRECT |
56672,88633
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0.000000008596 | DIRECT |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.000001646 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0.000001888 | DIRECT |
52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.0001218 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0.0006079 | DIRECT |
56672,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01045 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3593 | INHERITED FROM: Serine endopeptidases || Hepacivirin || Helper-component proteinase || Cysteine endopeptidases || Flavivirin || Nuclear-inclusion-a endopeptidase |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.6727 | INHERITED FROM: Aminopeptidase B || Aminopeptidases |
52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 1 | INHERITED FROM: Cysteine endopeptidases || Calicivirin |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,54001
57850 - RING/U-box
54001 - Cysteine proteinases | 0 | Direct |
82671,57424
82671 - SEA domain
57424 - LDL receptor-like module | 0 | Direct |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55486,51120
55486 - Metalloproteases ("zincins"), catalytic domain
51120 - beta-Roll | 0 | Direct |
49599,54001
49599 - TRAF domain-like
54001 - Cysteine proteinases | 0 | Direct |
52743,52025
52743 - Subtilisin-like
52025 - PA domain | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
56601,69189
56601 - beta-lactamase/transpeptidase-like
69189 - Penicillin-binding protein associated domain | 0 | Direct |
89043,50494
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | Direct |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
100895,56487
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like | 0 | Direct |
49854,49854
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
81761,53474
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
54001,46934
54001 - Cysteine proteinases
46934 - UBA-like | 0 | Direct |
56519,56601
56519 - Penicillin binding protein dimerisation domain
56601 - beta-lactamase/transpeptidase-like | 0 | Direct |
101821,53187
101821 - Aminopeptidase/glucanase lid domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
53092,55920
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | Direct |
53092,53092
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0 | Direct |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
54403,54001
54403 - Cystatin/monellin
54001 - Cysteine proteinases | 0 | Direct |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | Direct |
57603,57440
57603 - FnI-like domain
57440 - Kringle-like | 0 | Direct |
50156,52096
50156 - PDZ domain-like
52096 - ClpP/crotonase | 0 | Direct |
50494,56672
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | Direct |
53300,50494
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | Direct |
49899,50386
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | Direct |
89260,89260
89260 - Collagen-binding domain
89260 - Collagen-binding domain | 0 | Direct |
75001,54001
75001 - Dipeptidyl peptidase I (cathepsin C), exclusion domain
54001 - Cysteine proteinases | 0 | Direct |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
52949,53187
52949 - Macro domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
58091,49899
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
140367,143076
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like | 0 | Direct |
57424,49854
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | Direct |
49854,50494
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | Direct |
52129,81296
52129 - Caspase-like
81296 - E set domains | 0 | Direct |
50886,50886
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
103642,55920
103642 - Sec-C motif
55920 - Creatinase/aminopeptidase | 0 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
56601,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
49854,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
82671,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
46785,51306
46785 - "Winged helix" DNA-binding domain
51306 - LexA/Signal peptidase | 0 | Direct |
57184,50494
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | Direct |
55486,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | Direct |
159936,52949
159936 - NSP3A-like
52949 - Macro domain-like | 0 | Direct |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
49299,89260
49299 - PKD domain
89260 - Collagen-binding domain | 0 | Direct |
57535,53300
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | Direct |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | Direct |
49899,49854
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | Direct |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | Direct |
54001,55205
54001 - Cysteine proteinases
55205 - EPT/RTPC-like | 0 | Direct |
56487,57424
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | Direct |
57440,57196
57440 - Kringle-like
57196 - EGF/Laminin | 0 | Direct |
52317,141986
52317 - Class I glutamine amidotransferase-like
141986 - LD-carboxypeptidase A C-terminal domain-like | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
143076,101816
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | Direct |
49899,49599
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | Direct |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | Direct |
143791,54236
143791 - DUSP-like
54236 - Ubiquitin-like | 0 | Direct |
57630,57440
57630 - GLA-domain
57440 - Kringle-like | 0 | Direct |
53474,49785
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
55486,58091
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
53955,56601
53955 - Lysozyme-like
56601 - beta-lactamase/transpeptidase-like | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
88633,50494
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
101816,144246
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | Direct |
74924,54001
74924 - Cap-Gly domain
54001 - Cysteine proteinases | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
49854,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | Direct |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
56487,50494
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
55486,49899
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53335,142877
53335 - S-adenosyl-L-methionine-dependent methyltransferases
142877 - EndoU-like | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
52540,54211
52540 - P-loop containing nucleoside triphosphate hydrolases
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
57630,57184
57630 - GLA-domain
57184 - Growth factor receptor domain | 0 | Direct |
54001,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
55486,82895
55486 - Metalloproteases ("zincins"), catalytic domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
57424,56487
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
48371,54001
48371 - ARM repeat
54001 - Cysteine proteinases | 0 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
54236,54001
54236 - Ubiquitin-like
54001 - Cysteine proteinases | 0 | Direct |
49854,49899
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,89043
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
54001,144232
54001 - Cysteine proteinases
144232 - HIT/MYND zinc finger-like | 0 | Direct |
88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
50993,53474
50993 - Peptidase/esterase 'gauge' domain
53474 - alpha/beta-Hydrolases | 0 | Direct |
49464,53187
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | Direct |
159936,53335
159936 - NSP3A-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
143791,143791
143791 - DUSP-like
143791 - DUSP-like | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 1.78e-16 | Direct |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 3.548e-16 | Direct |
56672,88633
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0.000000008596 | Direct |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.000001646 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0.000001888 | Direct |
52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.0001218 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0.0006079 | Direct |
56672,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01045 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3593 | Inherited |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.6727 | Inherited |
52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57603,57440,57440
57603 - FnI-like domain
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
89043,50494,56672
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
53092,53092,55920
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | DIRECT |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
49854,49899,49854
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47090,55486,57440
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | DIRECT |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
53187,49464,53187
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
50494,52540,89043
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
49854,57424,56487
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | DIRECT |
57630,57196,57196
57630 - GLA-domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
143076,101816,144246
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | DIRECT |
49899,49854,57424
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | DIRECT |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
49854,49854,50494
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
56601,50886,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
49464,53187,49464
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
57535,57535,53300
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | DIRECT |
58091,49899,50386
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | DIRECT |
57196,57196,50494
57196 - EGF/Laminin
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
57630,57440,57440
57630 - GLA-domain
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
54001,143791,143791
54001 - Cysteine proteinases
143791 - DUSP-like
143791 - DUSP-like | 0 | DIRECT |
50494,56672,88633
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
88633,50494,52540
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56487,57424,57424
56487 - SRCR-like
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
50494,52540,56672
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | DIRECT |
55486,57440,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
49854,49854,57424
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55486,58091,49899
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57424,56487,50494
57424 - LDL receptor-like module
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57535,53300,50494
57535 - Complement control module/SCR domain
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
81761,53474,49785
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | DIRECT |
100895,56487,57424
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | DIRECT |
88633,88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
82671,49854,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49854,57424,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
50494,50156,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57630,57184,50494
57630 - GLA-domain
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
82671,57424,49854
82671 - SEA domain
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
55486,49899,49599
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | DIRECT |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
52540,89043,50494
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54001,88633,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
140367,143076,101816
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | DIRECT |
57424,49854,49899
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52540,52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.0009596 | DIRECT |
56672,52540,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.004074 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.6727 | INHERITED FROM: Aminopeptidase B || Aminopeptidases |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57603,57440,57440
57603 - FnI-like domain
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
89043,50494,56672
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | Direct |
53092,53092,55920
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | Direct |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
49854,49899,49854
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | Direct |
47090,55486,57440
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | Direct |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
53187,49464,53187
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
50494,52540,89043
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
49854,57424,56487
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | Direct |
57630,57196,57196
57630 - GLA-domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
143076,101816,144246
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | Direct |
49899,49854,57424
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | Direct |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
49854,49854,50494
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | Direct |
56601,50886,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
49464,53187,49464
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
57535,57535,53300
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | Direct |
58091,49899,50386
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | Direct |
57196,57196,50494
57196 - EGF/Laminin
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
57630,57440,57440
57630 - GLA-domain
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
54001,143791,143791
54001 - Cysteine proteinases
143791 - DUSP-like
143791 - DUSP-like | 0 | Direct |
50494,56672,88633
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
88633,50494,52540
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56487,57424,57424
56487 - SRCR-like
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
50494,52540,56672
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | Direct |
55486,57440,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
49854,49854,57424
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
55486,58091,49899
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57424,56487,50494
57424 - LDL receptor-like module
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | Direct |
57535,53300,50494
57535 - Complement control module/SCR domain
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | Direct |
81761,53474,49785
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | Direct |
100895,56487,57424
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | Direct |
88633,88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
82671,49854,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
49854,57424,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
50494,50156,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57630,57184,50494
57630 - GLA-domain
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | Direct |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
82671,57424,49854
82671 - SEA domain
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
55486,49899,49599
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | Direct |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
52540,89043,50494
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | Direct |
54001,88633,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
140367,143076,101816
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | Direct |
57424,49854,49899
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
52540,52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.0009596 | Direct |
56672,52540,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.004074 | Inherited |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.6727 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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