Enzyme Commission (EC): In cyclic amidines

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + 3:	root [root] <7>
+ + 2:	Hydrolases [3] <13>	(396|669)	(395|421|209)
+ 1:	Acting on carbon-nitrogen bonds, other than peptide bonds [3.5] <6>	(72|104)	(72|40|18)
0:	In cyclic amidines [3.5.4] <49>	(17|22)	(17|10|3)
- 1:	1-pyrroline-4-hydroxy-2-carboxylate deaminase [3.5.4.22]	(0|0)	(0|0|0)
- 1:	5'-deoxyadenosine deaminase [3.5.4.41]	(2|2)	(2|1|0)
- 1:	8-oxoguanine deaminase [3.5.4.32]	(0|0)	(0|0|0)
- 1:	ADP deaminase [3.5.4.7]	(0|0)	(0|0|0)
- 1:	AMP deaminase [3.5.4.6]	(1|1)	(1|0|0)
- 1:	ATP deaminase [3.5.4.18]	(0|0)	(0|0|0)
- 1:	Adenine deaminase [3.5.4.2]	(2|1)	(2|1|0)
- 1:	Adenosine deaminase [3.5.4.4]	(1|3)	(1|1|0)
- 1:	Adenosine-phosphate deaminase [3.5.4.17]	(0|0)	(0|0|0)
- 1:	Aminodeoxyfutalosine deaminase [3.5.4.40]	(1|1)	(1|0|0)
- 1:	Aminoimidazolase [3.5.4.8]	(0|0)	(0|0|0)
- 1:	Blasticidin-S deaminase [3.5.4.23]	(0|1)	(0|0|0)
- 1:	Creatinine deaminase [3.5.4.21]	(0|0)	(0|0|0)
- 1:	Cytidine deaminase [3.5.4.5]	(1|1)	(1|1|0)
- 1:	Cytosine deaminase [3.5.4.1]	(0|1)	(0|0|0)
- 1:	Diaminohydroxyphosphoribosylaminopyrimidine deaminase [3.5.4.26]	(2|2)	(2|1|0)
- 1:	Double-stranded RNA adenine deaminase [3.5.4.37]	(2|2)	(2|1|1)
- 1:	Ectoine hydrolase [3.5.4.44]	(0|0)	(0|0|0)
- 1:	GTP cyclohydrolase I [3.5.4.16]	(1|1)	(1|0|0)
- 1:	GTP cyclohydrolase II [3.5.4.25]	(2|2)	(2|1|0)
- 1:	GTP cyclohydrolase IIa [3.5.4.29]	(0|0)	(0|0|0)
- 1:	GTP cyclohydrolase IV [3.5.4.39]	(0|0)	(0|0|0)
- 1:	Guanine deaminase [3.5.4.3]	(2|1)	(2|1|0)
- 1:	Guanosine deaminase [3.5.4.15]	(0|0)	(0|0|0)
- 1:	Hydroxydechloroatrazine ethylaminohydrolase [3.5.4.43]	(0|0)	(0|0|0)
- 1:	IMP cyclohydrolase [3.5.4.10]	(3|3)	(3|1|0)
- 1:	Melamine deaminase [3.5.4.45]	(0|0)	(0|0|0)
- 1:	Methenyltetrahydrofolate cyclohydrolase [3.5.4.9]	(2|2)	(2|1|0)
- 1:	Methenyltetrahydromethanopterin cyclohydrolase [3.5.4.27]	(1|1)	(1|0|0)
- 1:	N-isopropylammelide isopropylaminohydrolase [3.5.4.42]	(0|0)	(0|0|0)
- 1:	Phosphoribosyl-AMP cyclohydrolase [3.5.4.19]	(2|3)	(2|2|1)
- 1:	Pterin deaminase [3.5.4.11]	(0|0)	(0|0|0)
- 1:	Pyrithiamine deaminase [3.5.4.20]	(0|0)	(0|0|0)
- 1:	S-adenosylhomocysteine deaminase [3.5.4.28]	(2|2)	(2|1|1)
- 1:	S-methyl-5'-thioadenosine deaminase [3.5.4.31]	(2|2)	(2|1|1)
- 1:	Sepiapterin deaminase [3.5.4.24]	(0|0)	(0|0|0)
- 1:	Single-stranded DNA cytosine deaminase [3.5.4.38]	(1|0)	(1|1|0)
- 1:	Transferred entry: 3.5.4.31 [3.5.4.n1]	(0|0)	(0|0|0)
- 1:	Transferred entry: 3.5.4.39 [3.5.4.n2]	(0|0)	(0|0|0)
- 1:	Transferred entry: 3.5.4.45 [3.5.4.n3]	(0|0)	(0|0|0)
- 1:	Transferred entry: 3.5.4.5 [3.5.4.14]	(0|0)	(0|0|0)
- 1:	cAMP deaminase [3.5.4.46]	(0|0)	(0|0|0)
- 1:	dCMP deaminase [3.5.4.12]	(1|1)	(1|0|0)
- 1:	dCTP deaminase [3.5.4.13]	(1|1)	(1|0|0)
- 1:	dCTP deaminase (dUMP-forming) [3.5.4.30]	(1|1)	(1|0|0)
- 1:	mRNA(cytosine(6666)) deaminase [3.5.4.36]	(1|0)	(1|0|0)
- 1:	tRNA(Ala)(adenine(37)) deaminase [3.5.4.34]	(0|0)	(0|0|0)
- 1:	tRNA(adenine(34)) deaminase [3.5.4.33]	(1|1)	(1|0|0)
- 1:	tRNA(cytosine(8)) deaminase [3.5.4.35]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this EC term (SDEC level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Methylglyoxal synthase-like	0	DIRECT
YrdC/RibB	0	DIRECT
all-alpha NTP pyrophosphatases	0	DIRECT
HisI-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
RibA-like	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
NAD(P)-binding Rossmann-fold domains	0	DIRECT
Archaeal IMP cyclohydrolase PurO	0	DIRECT
dUTPase-like	0	DIRECT
Methenyltetrahydromethanopterin cyclohydrolase	0	DIRECT
Dihydrofolate reductase-like	0.00000000007655	DIRECT
dsRNA-binding domain-like	0.3778	INHERITED FROM: Double-stranded RNA adenine deaminase
Metallo-dependent hydrolases	0.4852	INHERITED FROM: S-methyl-5'-thioadenosine deaminase || Guanine deaminase || AMP deaminase || Aminodeoxyfutalosine deaminase || 5'-deoxyadenosine deaminase || Adenine deaminase || Adenosine deaminase || S-adenosylhomocysteine deaminase
"Winged helix" DNA-binding domain	1	INHERITED FROM: Double-stranded RNA adenine deaminase
Composite domain of metallo-dependent hydrolases	1	INHERITED FROM: S-methyl-5'-thioadenosine deaminase || Guanine deaminase || 5'-deoxyadenosine deaminase || Adenine deaminase || S-adenosylhomocysteine deaminase

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Family

Family domains annotated to this EC term (SDEC level: Highly Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	0	DIRECT
RibD C-terminal domain-like	0	DIRECT
Cytidine deaminase	0	DIRECT
Tetrahydrofolate dehydrogenase/cyclohydrolase	0	DIRECT
Z-DNA binding domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Archaeal IMP cyclohydrolase PurO	0	DIRECT
GTP cyclohydrolase I	0	DIRECT
Cytosine deaminase catalytic domain	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
SAH/MTA deaminase-like	0	DIRECT
RibA-like	0	DIRECT
HisI-like	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC	0	DIRECT
SAH/MTA deaminase-like	0	DIRECT
Inosicase	0	DIRECT
Methenyltetrahydromethanopterin cyclohydrolase	0	DIRECT
dUTPase-like	0	DIRECT
HisE-like (PRA-PH)	0	DIRECT
L-histidinol dehydrogenase HisD	0.06232	INHERITED FROM: Phosphoribosyl-AMP cyclohydrolase
Double-stranded RNA-binding domain (dsRBD)	0.4701	INHERITED FROM: Double-stranded RNA adenine deaminase

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Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEC level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Methylglyoxal synthase-like	0	DIRECT
HisI-like	0	DIRECT
YrdC/RibB	0	DIRECT
Archaeal IMP cyclohydrolase PurO	0	DIRECT
all-alpha NTP pyrophosphatases	0	DIRECT
Methenyltetrahydromethanopterin cyclohydrolase	0	DIRECT
Cytidine deaminase-like	0	DIRECT
NAD(P)-binding Rossmann-fold domains	0	DIRECT
RibA-like	0	DIRECT
dUTPase-like	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Dihydrofolate reductase-like	0.00000000005611	DIRECT
dsRNA-binding domain-like	0.3421	INHERITED FROM: Double-stranded RNA adenine deaminase
Metallo-dependent hydrolases	0.4427	INHERITED FROM: AMP deaminase || S-adenosylhomocysteine deaminase || Adenine deaminase || S-methyl-5'-thioadenosine deaminase || Adenosine deaminase || Guanine deaminase || 5'-deoxyadenosine deaminase || Aminodeoxyfutalosine deaminase
"Winged helix" DNA-binding domain	1	INHERITED FROM: Double-stranded RNA adenine deaminase
Composite domain of metallo-dependent hydrolases	1	INHERITED FROM: S-adenosylhomocysteine deaminase || Adenine deaminase || S-methyl-5'-thioadenosine deaminase || Guanine deaminase || 5'-deoxyadenosine deaminase

Supra-domains annotated to this EC term (SPEC level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
101386,53720 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like	0	DIRECT
52335,53927 52335 - Methylglyoxal synthase-like 53927 - Cytidine deaminase-like	0	DIRECT
53927,53927 53927 - Cytidine deaminase-like 53927 - Cytidine deaminase-like	0	DIRECT
141734,101386 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases	0	DIRECT
53927,53597 53927 - Cytidine deaminase-like 53597 - Dihydrofolate reductase-like	0	DIRECT
55821,142695 55821 - YrdC/RibB 142695 - RibA-like	0	DIRECT
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0.000005006	DIRECT
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	1	INHERITED FROM: S-adenosylhomocysteine deaminase || S-methyl-5'-thioadenosine deaminase || Adenosine deaminase || 5'-deoxyadenosine deaminase
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	1	INHERITED FROM: Adenine deaminase || Guanine deaminase

Supra-domains annotated to this EC term (SPEC level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54768,54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0	DIRECT
141734,101386,53720 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like	0	DIRECT
51338,51556,51338 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	1	INHERITED FROM: S-adenosylhomocysteine deaminase || S-methyl-5'-thioadenosine deaminase