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Enzyme Commission (EC): Acting on acid anhydrides
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Nucleic acid-binding proteins | 0 | DIRECT |
"Winged helix" DNA-binding domain | 0 | DIRECT |
Apyrase | 0 | DIRECT |
EF-G C-terminal domain-like | 0 | DIRECT |
C-terminal domain of Ku80 | 0 | DIRECT |
RuvA domain 2-like | 0 | DIRECT |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
Positive stranded ssRNA viruses | 0 | DIRECT |
Nudix | 0 | DIRECT |
mRNA decapping enzyme DcpS N-terminal domain | 0 | DIRECT |
EndoU-like | 0 | DIRECT |
Dcp2 domain-like | 0 | DIRECT |
N-terminal domain of DnaB helicase | 0 | DIRECT |
Acylphosphatase/BLUF domain-like | 0 | DIRECT |
Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
all-alpha NTP pyrophosphatases | 0 | DIRECT |
ITPase-like | 0 | DIRECT |
HIT-like | 0 | DIRECT |
Restriction endonuclease-like | 0 | DIRECT |
Flavivirus capsid protein C | 0 | DIRECT |
DHH phosphoesterases | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Viral leader polypeptide zinc finger | 0 | DIRECT |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
Chromo domain-like | 0 | DIRECT |
DNA primase core | 0 | DIRECT |
Cdc48 domain 2-like | 0 | DIRECT |
Sec63 N-terminal domain-like | 0 | DIRECT |
Rap30/74 interaction domains | 0 | DIRECT |
DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
Inorganic pyrophosphatase | 0 | DIRECT |
Origin of replication-binding domain, RBD-like | 0 | DIRECT |
Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
AN1-like Zinc finger | 0 | DIRECT |
Translation proteins | 0 | DIRECT |
Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
Metallo-dependent phosphatases | 0 | DIRECT |
dUTPase-like | 0 | DIRECT |
DNA/RNA polymerases | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Trypsin-like serine proteases | 0.00000000000002806 | DIRECT |
vWA-like | 0.0000000000001715 | DIRECT |
Tudor/PWWP/MBT | 0.00000000007254 | DIRECT |
HMA, heavy metal-associated domain | 0.0000000003308 | DIRECT |
SAP domain | 0.000000007375 | DIRECT |
Replicase NSP9 | 0.00000001504 | DIRECT |
Coronavirus NSP10-like | 0.00000001504 | DIRECT |
Coronavirus NSP8-like | 0.00000001504 | DIRECT |
Coronavirus NSP7-like | 0.00000001504 | DIRECT |
Prokaryotic type I DNA topoisomerase | 0.00000002077 | DIRECT |
MIT domain | 0.00000003368 | DIRECT |
SCOP hierarchy in SUPERFAMILY | 0.00000003907 | DIRECT |
E set domains | 0.0000000759 | DIRECT |
Homing endonucleases | 0.0000002979 | DIRECT |
HRDC-like | 0.000001084 | DIRECT |
Hedgehog/intein (Hint) domain | 0.00000149 | DIRECT |
NSP3A-like | 0.000007894 | DIRECT |
F-box domain | 0.00001953 | DIRECT |
RNA-binding domain, RBD | 0.00007272 | DIRECT |
Somatomedin B domain | 0.000095 | DIRECT |
FYVE/PHD zinc finger | 0.000257 | DIRECT |
R3H domain | 0.0005598 | DIRECT |
CYTH-like phosphatases | 0.002048 | INHERITED FROM: Thiamine-triphosphatase || Triphosphatase || In phosphorus-containing anhydrides |
Bromodomain | 0.002075 | INHERITED FROM: Adenosinetriphosphatase |
His-Me finger endonucleases | 0.002095 | INHERITED FROM: Nucleotide diphosphatase || In phosphorus-containing anhydrides |
post-AAA+ oligomerization domain-like | 0.003208 | INHERITED FROM: Adenosinetriphosphatase || In phosphorus-containing anhydrides |
Ankyrin repeat | 0.003949 | INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase |
WW domain | 0.01106 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
SARS Nsp1-like | 0.01418 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
Ribonuclease Rh-like | 0.01747 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase || In phosphorus-containing anhydrides |
CCCH zinc finger | 0.06486 | INHERITED FROM: RNA helicase |
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.07683 | INHERITED FROM: Apyrase || UDP-sugar diphosphatase || In phosphorus-containing anhydrides |
Retrovirus zinc finger-like domains | 0.1237 | INHERITED FROM: dUTP diphosphatase || RNA helicase |
ADC-like | 0.1738 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Vesicle-fusing ATPase |
HD-domain/PDEase-like | 0.2032 | INHERITED FROM: Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Exopolyphosphatase || In phosphorus-containing anhydrides |
UBA-like | 0.2173 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement |
Calcium ATPase, transduction domain A | 0.2348 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Calcium ATPase, transmembrane domain M | 0.2379 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0.284 | INHERITED FROM: Undecaprenyl-diphosphate phosphatase || Dolichyldiphosphatase || In phosphorus-containing anhydrides |
NTF2-like | 0.2943 | INHERITED FROM: RNA helicase |
Actin-like ATPase domain | 0.4656 | INHERITED FROM: Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Non-chaperonin molecular chaperone ATPase || Adenosinetriphosphatase || Exopolyphosphatase || In phosphorus-containing anhydrides |
Retrovirus capsid dimerization domain-like | 0.6318 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Clavaminate synthase-like | 0.6437 | INHERITED FROM: RNA helicase |
HisI-like | 0.7675 | INHERITED FROM: Phosphoribosyl-ATP diphosphatase || In phosphorus-containing anhydrides |
Retrovirus capsid protein, N-terminal core domain | 0.9467 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
N-terminal Zn binding domain of HIV integrase | 0.9795 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
PH domain-like | 1 | INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement |
Cysteine proteinases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase || RNA helicase |
Retroviral matrix proteins | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Alkaline phosphatase-like | 1 | INHERITED FROM: Nucleotide diphosphatase || Bis(5'-adenosyl)-triphosphatase |
HAD-like | 1 | INHERITED FROM: Inorganic diphosphatase || Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase |
SurE-like | 1 | INHERITED FROM: Exopolyphosphatase || In phosphorus-containing anhydrides |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | INHERITED FROM: Adenosinetriphosphatase |
Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Macro domain-like | 1 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase |
DNA-binding domain of retroviral integrase | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Nucleic acid-binding proteins | 0 | Direct |
"Winged helix" DNA-binding domain | 0 | Direct |
Apyrase | 0 | Direct |
EF-G C-terminal domain-like | 0 | Direct |
C-terminal domain of Ku80 | 0 | Direct |
RuvA domain 2-like | 0 | Direct |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
Positive stranded ssRNA viruses | 0 | Direct |
Nudix | 0 | Direct |
mRNA decapping enzyme DcpS N-terminal domain | 0 | Direct |
EndoU-like | 0 | Direct |
Dcp2 domain-like | 0 | Direct |
N-terminal domain of DnaB helicase | 0 | Direct |
Acylphosphatase/BLUF domain-like | 0 | Direct |
Soluble domain of poliovirus core protein 3a | 0 | Direct |
all-alpha NTP pyrophosphatases | 0 | Direct |
ITPase-like | 0 | Direct |
HIT-like | 0 | Direct |
Restriction endonuclease-like | 0 | Direct |
Flavivirus capsid protein C | 0 | Direct |
DHH phosphoesterases | 0 | Direct |
SPOC domain-like | 0 | Direct |
Viral leader polypeptide zinc finger | 0 | Direct |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
Chromo domain-like | 0 | Direct |
DNA primase core | 0 | Direct |
Cdc48 domain 2-like | 0 | Direct |
Sec63 N-terminal domain-like | 0 | Direct |
Rap30/74 interaction domains | 0 | Direct |
DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
Inorganic pyrophosphatase | 0 | Direct |
Origin of replication-binding domain, RBD-like | 0 | Direct |
Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
AN1-like Zinc finger | 0 | Direct |
Translation proteins | 0 | Direct |
Viral glycoprotein, central and dimerisation domains | 0 | Direct |
Metallo-dependent phosphatases | 0 | Direct |
dUTPase-like | 0 | Direct |
DNA/RNA polymerases | 0 | Direct |
BRK domain-like | 0 | Direct |
Trypsin-like serine proteases | 0.00000000000002806 | Direct |
vWA-like | 0.0000000000001715 | Direct |
Tudor/PWWP/MBT | 0.00000000007254 | Direct |
HMA, heavy metal-associated domain | 0.0000000003308 | Direct |
SAP domain | 0.000000007375 | Direct |
Replicase NSP9 | 0.00000001504 | Direct |
Coronavirus NSP10-like | 0.00000001504 | Direct |
Coronavirus NSP8-like | 0.00000001504 | Direct |
Coronavirus NSP7-like | 0.00000001504 | Direct |
Prokaryotic type I DNA topoisomerase | 0.00000002077 | Direct |
MIT domain | 0.00000003368 | Direct |
SCOP hierarchy in SUPERFAMILY | 0.00000003907 | Direct |
E set domains | 0.0000000759 | Direct |
Homing endonucleases | 0.0000002979 | Direct |
HRDC-like | 0.000001084 | Direct |
Hedgehog/intein (Hint) domain | 0.00000149 | Direct |
NSP3A-like | 0.000007894 | Direct |
F-box domain | 0.00001953 | Direct |
RNA-binding domain, RBD | 0.00007272 | Direct |
Somatomedin B domain | 0.000095 | Direct |
FYVE/PHD zinc finger | 0.000257 | Direct |
R3H domain | 0.0005598 | Direct |
CYTH-like phosphatases | 0.002048 | Inherited |
Bromodomain | 0.002075 | Inherited |
His-Me finger endonucleases | 0.002095 | Inherited |
post-AAA+ oligomerization domain-like | 0.003208 | Inherited |
Ankyrin repeat | 0.003949 | Inherited |
WW domain | 0.01106 | Inherited |
SARS Nsp1-like | 0.01418 | Inherited |
Ribonuclease Rh-like | 0.01747 | Inherited |
CCCH zinc finger | 0.06486 | Inherited |
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.07683 | Inherited |
Retrovirus zinc finger-like domains | 0.1237 | Inherited |
ADC-like | 0.1738 | Inherited |
HD-domain/PDEase-like | 0.2032 | Inherited |
UBA-like | 0.2173 | Inherited |
Calcium ATPase, transduction domain A | 0.2348 | Inherited |
Calcium ATPase, transmembrane domain M | 0.2379 | Inherited |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0.284 | Inherited |
NTF2-like | 0.2943 | Inherited |
Actin-like ATPase domain | 0.4656 | Inherited |
Retrovirus capsid dimerization domain-like | 0.6318 | Inherited |
Clavaminate synthase-like | 0.6437 | Inherited |
HisI-like | 0.7675 | Inherited |
Retrovirus capsid protein, N-terminal core domain | 0.9467 | Inherited |
N-terminal Zn binding domain of HIV integrase | 0.9795 | Inherited |
PH domain-like | 1 | Inherited |
Cysteine proteinases | 1 | Inherited |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
Retroviral matrix proteins | 1 | Inherited |
Alkaline phosphatase-like | 1 | Inherited |
HAD-like | 1 | Inherited |
Ribonuclease H-like | 1 | Inherited |
SurE-like | 1 | Inherited |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | Inherited |
Acid proteases | 1 | Inherited |
Macro domain-like | 1 | Inherited |
DNA-binding domain of retroviral integrase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
ITPase (Ham1) | 0 | DIRECT |
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 0 | DIRECT |
Tandem AAA-ATPase domain | 0 | DIRECT |
ADPRibase-Mn-like | 0 | DIRECT |
HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | DIRECT |
CDH-like | 0 | DIRECT |
XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
Ppx/GppA phosphatase | 0 | DIRECT |
Viral proteases | 0 | DIRECT |
GUCT domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Viral cysteine protease of trypsin fold | 0 | DIRECT |
Elongation factors | 0 | DIRECT |
RecQ helicase DNA-binding domain-like | 0 | DIRECT |
mRNA decapping enzyme DcpS C-terminal domain | 0 | DIRECT |
mRNA decapping enzyme DcpS N-terminal domain | 0 | DIRECT |
Apyrase | 0 | DIRECT |
MgsA/YrvN C-terminal domain-like | 0 | DIRECT |
Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
FMDV leader protease | 0 | DIRECT |
RNA helicase | 0 | DIRECT |
Sec63 C-terminal domain-like | 0 | DIRECT |
Dcp2 box A domain | 0 | DIRECT |
Ku70 subunit middle domain | 0 | DIRECT |
Sec63 N-terminal domain | 0 | DIRECT |
Nsp15 N-terminal domain-like | 0 | DIRECT |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
DNA-binding domain from rap30 | 0 | DIRECT |
AN1-like Zinc finger | 0 | DIRECT |
Ku70 subunit N-terminal domain | 0 | DIRECT |
C-terminal domain of Ku80 | 0 | DIRECT |
Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | DIRECT |
Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
Replication initiation protein E1 | 0 | DIRECT |
Actin/HSP70 | 0 | DIRECT |
Class II viral fusion proteins C-terminal domain | 0 | DIRECT |
Cdc48 N-terminal domain-like | 0 | DIRECT |
Flavivirus capsid protein C | 0 | DIRECT |
HRDC domain from helicases | 0 | DIRECT |
Chromo domain | 0 | DIRECT |
Caliciviridae-like VP | 0 | DIRECT |
Nsp15 C-terminal domain-like | 0 | DIRECT |
G proteins | 0 | DIRECT |
NADH pyrophosphatase | 0 | DIRECT |
DNA helicase RuvA subunit, middle domain | 0 | DIRECT |
Achaeal helicase C-terminal domain | 0 | DIRECT |
MutT-like | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
Helicase-like "domain" of reverse gyrase | 0 | DIRECT |
mRNA decapping enzyme-like | 0 | DIRECT |
DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
Ppx associated domain | 0 | DIRECT |
Ku80 subunit middle domain | 0 | DIRECT |
MazG-like | 0 | DIRECT |
RecG "wedge" domain | 0 | DIRECT |
Macro domain | 0 | DIRECT |
DNA helicase RuvA subunit, N-terminal domain | 0 | DIRECT |
Helicase DNA-binding domain | 0 | DIRECT |
Rap30/74 interaction domains | 0 | DIRECT |
Maf-like | 0 | DIRECT |
N-terminal domain of DnaB helicase | 0 | DIRECT |
mRNA cap methylase | 0 | DIRECT |
Inorganic pyrophosphatase | 0 | DIRECT |
RNA-dependent RNA-polymerase | 0 | DIRECT |
Acylphosphatase-like | 0 | DIRECT |
TIP49 domain | 0 | DIRECT |
Viral leader polypeptide zinc finger | 0 | DIRECT |
dUTPase-like | 0 | DIRECT |
Extended AAA-ATPase domain | 0 | DIRECT |
Ku80 subunit N-terminal domain | 0 | DIRECT |
HisE-like (PRA-PH) | 0 | DIRECT |
EF-G/eEF-2 domains III and V | 0 | DIRECT |
Manganese-dependent inorganic pyrophosphatase (family II) | 0 | DIRECT |
Cdc48 domain 2-like | 0 | DIRECT |
CYTH domain | 0.000000000000001463 | DIRECT |
Mason-Pfizer monkey virus matrix protein | 0.0000000000226 | DIRECT |
HMA, heavy metal-associated domain | 0.000000000138 | DIRECT |
SAP domain | 0.000000003152 | DIRECT |
Coronavirus NSP7-like | 0.000000003491 | DIRECT |
Coronavirus NSP10-like | 0.000000003491 | DIRECT |
Coronavirus NSP8-like | 0.000000003491 | DIRECT |
Replicase NSP9 | 0.000000003491 | DIRECT |
MIT domain | 0.000000007073 | DIRECT |
Prokaryotic type I DNA topoisomerase | 0.000000008891 | DIRECT |
Tudor domain | 0.00000181 | DIRECT |
NSP3A-like | 0.000002782 | DIRECT |
Intein (protein splicing domain) | 0.000003518 | DIRECT |
F-box domain | 0.00001364 | DIRECT |
Somatomedin B domain | 0.0000513 | DIRECT |
AlkB-like | 0.0001434 | DIRECT |
Protein serine/threonine phosphatase | 0.0002872 | DIRECT |
R3H domain | 0.000314 | DIRECT |
Bromodomain | 0.001422 | INHERITED FROM: Adenosinetriphosphatase |
PHD domain | 0.001544 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase |
Ankyrin repeat | 0.002141 | INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase |
WW domain | 0.007869 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
SARS Nsp1-like | 0.009821 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
Ribonuclease Rh-like | 0.01281 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase || In phosphorus-containing anhydrides |
SPRY domain | 0.0148 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
Pleckstrin-homology domain (PH domain) | 0.04578 | INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement |
CCCH zinc finger | 0.05112 | INHERITED FROM: RNA helicase |
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.05136 | INHERITED FROM: Apyrase || UDP-sugar diphosphatase || In phosphorus-containing anhydrides |
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.05136 | INHERITED FROM: Apyrase || UDP-sugar diphosphatase || In phosphorus-containing anhydrides |
Meta-cation ATPase, catalytic domain P | 0.05566 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Retrovirus zinc finger-like domains | 0.06424 | INHERITED FROM: dUTP diphosphatase || RNA helicase |
NagD-like | 0.1225 | INHERITED FROM: Inorganic diphosphatase || In phosphorus-containing anhydrides |
Calcium ATPase, transduction domain A | 0.23 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Canonical RBD | 0.2346 | INHERITED FROM: RNA helicase |
Retrovirus capsid protein C-terminal domain | 0.487 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
HisI-like | 0.535 | INHERITED FROM: Phosphoribosyl-ATP diphosphatase || In phosphorus-containing anhydrides |
beta-Phosphoglucomutase-like | 0.6067 | INHERITED FROM: Inorganic diphosphatase || In phosphorus-containing anhydrides |
RecA protein-like (ATPase-domain) | 0.6588 | INHERITED FROM: Nucleoside-triphosphate phosphatase |
Calcium ATPase, transmembrane domain M | 0.6916 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Retroviral protease (retropepsin) | 0.7122 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
L-histidinol dehydrogenase HisD | 0.779 | INHERITED FROM: Phosphoribosyl-ATP diphosphatase |
Retrovirus capsid protein, N-terminal core domain | 0.7798 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
N-terminal Zn binding domain of HIV integrase | 0.8565 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
DNA-binding domain of retroviral integrase | 0.8843 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Ribonuclease H | 1 | INHERITED FROM: dUTP diphosphatase |
Retroviral integrase, catalytic domain | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
SurE-like | 1 | INHERITED FROM: Exopolyphosphatase || In phosphorus-containing anhydrides |
Reverse transcriptase | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
ITPase (Ham1) | 0 | Direct |
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 0 | Direct |
Tandem AAA-ATPase domain | 0 | Direct |
ADPRibase-Mn-like | 0 | Direct |
HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | Direct |
CDH-like | 0 | Direct |
XPF/Rad1/Mus81 nuclease | 0 | Direct |
Ppx/GppA phosphatase | 0 | Direct |
Viral proteases | 0 | Direct |
GUCT domain | 0 | Direct |
BRK domain-like | 0 | Direct |
Viral cysteine protease of trypsin fold | 0 | Direct |
Elongation factors | 0 | Direct |
RecQ helicase DNA-binding domain-like | 0 | Direct |
mRNA decapping enzyme DcpS C-terminal domain | 0 | Direct |
mRNA decapping enzyme DcpS N-terminal domain | 0 | Direct |
Apyrase | 0 | Direct |
MgsA/YrvN C-terminal domain-like | 0 | Direct |
Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
FMDV leader protease | 0 | Direct |
RNA helicase | 0 | Direct |
Sec63 C-terminal domain-like | 0 | Direct |
Dcp2 box A domain | 0 | Direct |
Ku70 subunit middle domain | 0 | Direct |
Sec63 N-terminal domain | 0 | Direct |
Nsp15 N-terminal domain-like | 0 | Direct |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
Viral glycoprotein, central and dimerisation domains | 0 | Direct |
DNA-binding domain from rap30 | 0 | Direct |
AN1-like Zinc finger | 0 | Direct |
Ku70 subunit N-terminal domain | 0 | Direct |
C-terminal domain of Ku80 | 0 | Direct |
Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | Direct |
Soluble domain of poliovirus core protein 3a | 0 | Direct |
Replication initiation protein E1 | 0 | Direct |
Actin/HSP70 | 0 | Direct |
Class II viral fusion proteins C-terminal domain | 0 | Direct |
Cdc48 N-terminal domain-like | 0 | Direct |
Flavivirus capsid protein C | 0 | Direct |
HRDC domain from helicases | 0 | Direct |
Chromo domain | 0 | Direct |
Caliciviridae-like VP | 0 | Direct |
Nsp15 C-terminal domain-like | 0 | Direct |
G proteins | 0 | Direct |
NADH pyrophosphatase | 0 | Direct |
DNA helicase RuvA subunit, middle domain | 0 | Direct |
Achaeal helicase C-terminal domain | 0 | Direct |
MutT-like | 0 | Direct |
NTF2-like | 0 | Direct |
Helicase-like "domain" of reverse gyrase | 0 | Direct |
mRNA decapping enzyme-like | 0 | Direct |
DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
Ppx associated domain | 0 | Direct |
Ku80 subunit middle domain | 0 | Direct |
MazG-like | 0 | Direct |
RecG "wedge" domain | 0 | Direct |
Macro domain | 0 | Direct |
DNA helicase RuvA subunit, N-terminal domain | 0 | Direct |
Helicase DNA-binding domain | 0 | Direct |
Rap30/74 interaction domains | 0 | Direct |
Maf-like | 0 | Direct |
N-terminal domain of DnaB helicase | 0 | Direct |
mRNA cap methylase | 0 | Direct |
Inorganic pyrophosphatase | 0 | Direct |
RNA-dependent RNA-polymerase | 0 | Direct |
Acylphosphatase-like | 0 | Direct |
TIP49 domain | 0 | Direct |
Viral leader polypeptide zinc finger | 0 | Direct |
dUTPase-like | 0 | Direct |
Extended AAA-ATPase domain | 0 | Direct |
Ku80 subunit N-terminal domain | 0 | Direct |
HisE-like (PRA-PH) | 0 | Direct |
EF-G/eEF-2 domains III and V | 0 | Direct |
Manganese-dependent inorganic pyrophosphatase (family II) | 0 | Direct |
Cdc48 domain 2-like | 0 | Direct |
CYTH domain | 0.000000000000001463 | Direct |
Mason-Pfizer monkey virus matrix protein | 0.0000000000226 | Direct |
HMA, heavy metal-associated domain | 0.000000000138 | Direct |
SAP domain | 0.000000003152 | Direct |
Coronavirus NSP7-like | 0.000000003491 | Direct |
Coronavirus NSP10-like | 0.000000003491 | Direct |
Coronavirus NSP8-like | 0.000000003491 | Direct |
Replicase NSP9 | 0.000000003491 | Direct |
MIT domain | 0.000000007073 | Direct |
Prokaryotic type I DNA topoisomerase | 0.000000008891 | Direct |
Tudor domain | 0.00000181 | Direct |
NSP3A-like | 0.000002782 | Direct |
Intein (protein splicing domain) | 0.000003518 | Direct |
F-box domain | 0.00001364 | Direct |
Somatomedin B domain | 0.0000513 | Direct |
AlkB-like | 0.0001434 | Direct |
Protein serine/threonine phosphatase | 0.0002872 | Direct |
R3H domain | 0.000314 | Direct |
Bromodomain | 0.001422 | Inherited |
PHD domain | 0.001544 | Inherited |
Ankyrin repeat | 0.002141 | Inherited |
WW domain | 0.007869 | Inherited |
SARS Nsp1-like | 0.009821 | Inherited |
Ribonuclease Rh-like | 0.01281 | Inherited |
SPRY domain | 0.0148 | Inherited |
Pleckstrin-homology domain (PH domain) | 0.04578 | Inherited |
CCCH zinc finger | 0.05112 | Inherited |
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.05136 | Inherited |
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.05136 | Inherited |
Meta-cation ATPase, catalytic domain P | 0.05566 | Inherited |
Retrovirus zinc finger-like domains | 0.06424 | Inherited |
NagD-like | 0.1225 | Inherited |
Calcium ATPase, transduction domain A | 0.23 | Inherited |
Canonical RBD | 0.2346 | Inherited |
Retrovirus capsid protein C-terminal domain | 0.487 | Inherited |
HisI-like | 0.535 | Inherited |
beta-Phosphoglucomutase-like | 0.6067 | Inherited |
RecA protein-like (ATPase-domain) | 0.6588 | Inherited |
Calcium ATPase, transmembrane domain M | 0.6916 | Inherited |
Retroviral protease (retropepsin) | 0.7122 | Inherited |
L-histidinol dehydrogenase HisD | 0.779 | Inherited |
Retrovirus capsid protein, N-terminal core domain | 0.7798 | Inherited |
N-terminal Zn binding domain of HIV integrase | 0.8565 | Inherited |
DNA-binding domain of retroviral integrase | 0.8843 | Inherited |
Ribonuclease H | 1 | Inherited |
Retroviral integrase, catalytic domain | 1 | Inherited |
SurE-like | 1 | Inherited |
Reverse transcriptase | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
AN1-like Zinc finger | 0 | DIRECT |
"Winged helix" DNA-binding domain | 0 | DIRECT |
Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
Flavivirus capsid protein C | 0 | DIRECT |
EF-G C-terminal domain-like | 0 | DIRECT |
Sec63 N-terminal domain-like | 0 | DIRECT |
Apyrase | 0 | DIRECT |
Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
Viral leader polypeptide zinc finger | 0 | DIRECT |
Restriction endonuclease-like | 0 | DIRECT |
Cdc48 domain 2-like | 0 | DIRECT |
all-alpha NTP pyrophosphatases | 0 | DIRECT |
DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Rap30/74 interaction domains | 0 | DIRECT |
Dcp2 domain-like | 0 | DIRECT |
DNA primase core | 0 | DIRECT |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
EndoU-like | 0 | DIRECT |
Chromo domain-like | 0 | DIRECT |
mRNA decapping enzyme DcpS N-terminal domain | 0 | DIRECT |
Nudix | 0 | DIRECT |
Inorganic pyrophosphatase | 0 | DIRECT |
P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
Metallo-dependent phosphatases | 0 | DIRECT |
HIT-like | 0 | DIRECT |
N-terminal domain of DnaB helicase | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
DHH phosphoesterases | 0 | DIRECT |
C-terminal domain of Ku80 | 0 | DIRECT |
Acylphosphatase/BLUF domain-like | 0 | DIRECT |
Nucleic acid-binding proteins | 0 | DIRECT |
Translation proteins | 0 | DIRECT |
DNA/RNA polymerases | 0 | DIRECT |
Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
dUTPase-like | 0 | DIRECT |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
Origin of replication-binding domain, RBD-like | 0 | DIRECT |
Positive stranded ssRNA viruses | 0 | DIRECT |
ITPase-like | 0 | DIRECT |
RuvA domain 2-like | 0 | DIRECT |
Trypsin-like serine proteases | 0.00000000000001978 | DIRECT |
vWA-like | 0.0000000000001217 | DIRECT |
Tudor/PWWP/MBT | 0.00000000005312 | DIRECT |
HMA, heavy metal-associated domain | 0.0000000002445 | DIRECT |
SAP domain | 0.000000005555 | DIRECT |
Replicase NSP9 | 0.00000001137 | DIRECT |
Coronavirus NSP8-like | 0.00000001137 | DIRECT |
Coronavirus NSP10-like | 0.00000001137 | DIRECT |
Coronavirus NSP7-like | 0.00000001137 | DIRECT |
Prokaryotic type I DNA topoisomerase | 0.00000001573 | DIRECT |
MIT domain | 0.00000002557 | DIRECT |
E set domains | 0.00000005792 | DIRECT |
Homing endonucleases | 0.0000002295 | DIRECT |
HRDC-like | 0.000000844 | DIRECT |
Hedgehog/intein (Hint) domain | 0.000001163 | DIRECT |
NSP3A-like | 0.000006227 | DIRECT |
F-box domain | 0.00001555 | DIRECT |
RNA-binding domain, RBD | 0.00005837 | DIRECT |
Somatomedin B domain | 0.0000765 | DIRECT |
FYVE/PHD zinc finger | 0.0002089 | DIRECT |
R3H domain | 0.0004584 | DIRECT |
CYTH-like phosphatases | 0.001704 | INHERITED FROM: Thiamine-triphosphatase || Triphosphatase || In phosphorus-containing anhydrides |
Bromodomain | 0.001727 | INHERITED FROM: Adenosinetriphosphatase |
His-Me finger endonucleases | 0.001743 | INHERITED FROM: In phosphorus-containing anhydrides || Nucleotide diphosphatase |
post-AAA+ oligomerization domain-like | 0.002681 | INHERITED FROM: In phosphorus-containing anhydrides || Adenosinetriphosphatase |
Ankyrin repeat | 0.003305 | INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase |
WW domain | 0.00938 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
SARS Nsp1-like | 0.01206 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
Ribonuclease Rh-like | 0.0149 | INHERITED FROM: Nucleoside-triphosphate phosphatase || Acting on ATP; involved in cellular and subcellular movement || In phosphorus-containing anhydrides || RNA helicase |
CCCH zinc finger | 0.05626 | INHERITED FROM: RNA helicase |
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | INHERITED FROM: UDP-sugar diphosphatase || In phosphorus-containing anhydrides || Apyrase |
Retrovirus zinc finger-like domains | 0.1082 | INHERITED FROM: dUTP diphosphatase || RNA helicase |
ADC-like | 0.1534 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Vesicle-fusing ATPase |
HD-domain/PDEase-like | 0.1802 | INHERITED FROM: In phosphorus-containing anhydrides || Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Exopolyphosphatase |
UBA-like | 0.193 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement |
Calcium ATPase, transduction domain A | 0.209 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Calcium ATPase, transmembrane domain M | 0.212 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0.2558 | INHERITED FROM: In phosphorus-containing anhydrides || Dolichyldiphosphatase || Undecaprenyl-diphosphate phosphatase |
NTF2-like | 0.2653 | INHERITED FROM: RNA helicase |
Actin-like ATPase domain | 0.4244 | INHERITED FROM: In phosphorus-containing anhydrides || Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Exopolyphosphatase || Non-chaperonin molecular chaperone ATPase || Adenosinetriphosphatase |
Retrovirus capsid dimerization domain-like | 0.58 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Clavaminate synthase-like | 0.5909 | INHERITED FROM: RNA helicase |
HisI-like | 0.7063 | INHERITED FROM: In phosphorus-containing anhydrides || Phosphoribosyl-ATP diphosphatase |
Retrovirus capsid protein, N-terminal core domain | 0.8755 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
N-terminal Zn binding domain of HIV integrase | 0.9067 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
DNA-binding domain of retroviral integrase | 0.9283 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase |
Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
PH domain-like | 1 | INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement |
Retroviral matrix proteins | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
SurE-like | 1 | INHERITED FROM: In phosphorus-containing anhydrides || Exopolyphosphatase |
Cysteine proteinases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase |
Macro domain-like | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase || Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
HAD-like | 1 | INHERITED FROM: Inorganic diphosphatase || Acting on acid anhydrides; catalyzing transmembrane movement of substances |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | INHERITED FROM: Adenosinetriphosphatase |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase || RNA helicase |
Alkaline phosphatase-like | 1 | INHERITED FROM: Nucleotide diphosphatase || Bis(5'-adenosyl)-triphosphatase |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
AN1-like Zinc finger | 0 | Direct |
"Winged helix" DNA-binding domain | 0 | Direct |
Soluble domain of poliovirus core protein 3a | 0 | Direct |
Flavivirus capsid protein C | 0 | Direct |
EF-G C-terminal domain-like | 0 | Direct |
Sec63 N-terminal domain-like | 0 | Direct |
Apyrase | 0 | Direct |
Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
Viral leader polypeptide zinc finger | 0 | Direct |
Restriction endonuclease-like | 0 | Direct |
Cdc48 domain 2-like | 0 | Direct |
all-alpha NTP pyrophosphatases | 0 | Direct |
DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
SPOC domain-like | 0 | Direct |
Rap30/74 interaction domains | 0 | Direct |
Dcp2 domain-like | 0 | Direct |
DNA primase core | 0 | Direct |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
EndoU-like | 0 | Direct |
Chromo domain-like | 0 | Direct |
mRNA decapping enzyme DcpS N-terminal domain | 0 | Direct |
Nudix | 0 | Direct |
Inorganic pyrophosphatase | 0 | Direct |
P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
Metallo-dependent phosphatases | 0 | Direct |
HIT-like | 0 | Direct |
N-terminal domain of DnaB helicase | 0 | Direct |
BRK domain-like | 0 | Direct |
DHH phosphoesterases | 0 | Direct |
C-terminal domain of Ku80 | 0 | Direct |
Acylphosphatase/BLUF domain-like | 0 | Direct |
Nucleic acid-binding proteins | 0 | Direct |
Translation proteins | 0 | Direct |
DNA/RNA polymerases | 0 | Direct |
Viral glycoprotein, central and dimerisation domains | 0 | Direct |
dUTPase-like | 0 | Direct |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
Origin of replication-binding domain, RBD-like | 0 | Direct |
Positive stranded ssRNA viruses | 0 | Direct |
ITPase-like | 0 | Direct |
RuvA domain 2-like | 0 | Direct |
Trypsin-like serine proteases | 0.00000000000001978 | Direct |
vWA-like | 0.0000000000001217 | Direct |
Tudor/PWWP/MBT | 0.00000000005312 | Direct |
HMA, heavy metal-associated domain | 0.0000000002445 | Direct |
SAP domain | 0.000000005555 | Direct |
Replicase NSP9 | 0.00000001137 | Direct |
Coronavirus NSP8-like | 0.00000001137 | Direct |
Coronavirus NSP10-like | 0.00000001137 | Direct |
Coronavirus NSP7-like | 0.00000001137 | Direct |
Prokaryotic type I DNA topoisomerase | 0.00000001573 | Direct |
MIT domain | 0.00000002557 | Direct |
E set domains | 0.00000005792 | Direct |
Homing endonucleases | 0.0000002295 | Direct |
HRDC-like | 0.000000844 | Direct |
Hedgehog/intein (Hint) domain | 0.000001163 | Direct |
NSP3A-like | 0.000006227 | Direct |
F-box domain | 0.00001555 | Direct |
RNA-binding domain, RBD | 0.00005837 | Direct |
Somatomedin B domain | 0.0000765 | Direct |
FYVE/PHD zinc finger | 0.0002089 | Direct |
R3H domain | 0.0004584 | Direct |
CYTH-like phosphatases | 0.001704 | Inherited |
Bromodomain | 0.001727 | Inherited |
His-Me finger endonucleases | 0.001743 | Inherited |
post-AAA+ oligomerization domain-like | 0.002681 | Inherited |
Ankyrin repeat | 0.003305 | Inherited |
WW domain | 0.00938 | Inherited |
SARS Nsp1-like | 0.01206 | Inherited |
Ribonuclease Rh-like | 0.0149 | Inherited |
CCCH zinc finger | 0.05626 | Inherited |
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | Inherited |
Retrovirus zinc finger-like domains | 0.1082 | Inherited |
ADC-like | 0.1534 | Inherited |
HD-domain/PDEase-like | 0.1802 | Inherited |
UBA-like | 0.193 | Inherited |
Calcium ATPase, transduction domain A | 0.209 | Inherited |
Calcium ATPase, transmembrane domain M | 0.212 | Inherited |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0.2558 | Inherited |
NTF2-like | 0.2653 | Inherited |
Actin-like ATPase domain | 0.4244 | Inherited |
Retrovirus capsid dimerization domain-like | 0.58 | Inherited |
Clavaminate synthase-like | 0.5909 | Inherited |
HisI-like | 0.7063 | Inherited |
Retrovirus capsid protein, N-terminal core domain | 0.8755 | Inherited |
N-terminal Zn binding domain of HIV integrase | 0.9067 | Inherited |
DNA-binding domain of retroviral integrase | 0.9283 | Inherited |
Ribonuclease H-like | 1 | Inherited |
Acid proteases | 1 | Inherited |
PH domain-like | 1 | Inherited |
Retroviral matrix proteins | 1 | Inherited |
SurE-like | 1 | Inherited |
Cysteine proteinases | 1 | Inherited |
Macro domain-like | 1 | Inherited |
HAD-like | 1 | Inherited |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | Inherited |
S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
Alkaline phosphatase-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
102860,54197 102860 - mRNA decapping enzyme DcpS N-terminal domain 54197 - HIT-like | 0 | DIRECT |
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52156 52540 - P-loop containing nucleoside triphosphate hydrolases 52156 - Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | DIRECT |
55608,56712 55608 - Homing endonucleases 56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
52540,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
55811,55811 55811 - Nudix 55811 - Nudix | 0 | DIRECT |
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like | 0 | DIRECT |
52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | DIRECT |
100939,68906 100939 - SPOC domain-like 68906 - SAP domain | 0 | DIRECT |
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains | 0 | DIRECT |
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
140586,55811 140586 - Dcp2 domain-like 55811 - Nudix | 0 | DIRECT |
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
101386,101386 101386 - all-alpha NTP pyrophosphatases 101386 - all-alpha NTP pyrophosphatases | 0 | DIRECT |
54980,54980 54980 - EF-G C-terminal domain-like 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
101386,53720 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | DIRECT |
100939,101420 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80 | 0 | DIRECT |
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
-9,52540 -9 - PDB 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0 | DIRECT |
52540,-9 52540 - P-loop containing nucleoside triphosphate hydrolases -9 - PDB | 0 | DIRECT |
52156,50447 52156 - Initiation factor IF2/eIF5b, domain 3 50447 - Translation proteins | 0 | DIRECT |
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases | 0 | DIRECT |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
52540,-8 52540 - P-loop containing nucleoside triphosphate hydrolases -8 - ECOD | 0 | DIRECT |
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases | 0 | DIRECT |
46785,47819 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like | 0 | DIRECT |
52540,57756 52540 - P-loop containing nucleoside triphosphate hydrolases 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
141734,101386 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases | 0 | DIRECT |
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like | 0 | DIRECT |
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like | 0 | DIRECT |
53067,109604 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | DIRECT |
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
116846,52540 116846 - MIT domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50916,46785 50916 - Rap30/74 interaction domains 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47781,46929 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
160481,160481 160481 - BRK domain-like 160481 - BRK domain-like | 0 | DIRECT |
50249,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,49899 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
158702,81296 158702 - Sec63 N-terminal domain-like 81296 - E set domains | 0 | DIRECT |
56731,52540 56731 - DNA primase core 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | DIRECT |
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like | 0 | DIRECT |
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
158702,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
46785,158702 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like | 0 | DIRECT |
50447,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51283,51283 51283 - dUTPase-like 51283 - dUTPase-like | 0 | DIRECT |
50249,47781 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like | 0 | DIRECT |
55464,52540 55464 - Origin of replication-binding domain, RBD-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53300,100939 53300 - vWA-like 100939 - SPOC domain-like | 0 | DIRECT |
52540,48403 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat | 0 | DIRECT |
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like | 0 | DIRECT |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | DIRECT |
48024,52540 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,54928 52540 - P-loop containing nucleoside triphosphate hydrolases 54928 - RNA-binding domain, RBD | 0 | DIRECT |
52540,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain | 0.0000000000003508 | DIRECT |
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000001872 | DIRECT |
57756,51283 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.00000000004607 | DIRECT |
51283,50630 51283 - dUTPase-like 50630 - Acid proteases | 0.00000000004607 | DIRECT |
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000007906 | DIRECT |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.000000005555 | DIRECT |
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like | 0.00000001137 | DIRECT |
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0.00000001137 | DIRECT |
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0.00000001137 | DIRECT |
51294,55608 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases | 0.00000003829 | DIRECT |
56712,51294 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0.000003274 | DIRECT |
53649,54060 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 0.000005345 | DIRECT |
90188,90188 90188 - Somatomedin B domain 90188 - Somatomedin B domain | 0.0000765 | DIRECT |
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.0000765 | DIRECT |
53098,51283 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.0000765 | DIRECT |
51283,46919 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | DIRECT |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.00009518 | DIRECT |
55608,52540 55608 - Homing endonucleases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0001909 | DIRECT |
-8,52540 -8 - ECOD 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001909 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
56672,46919 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0.001909 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0.002681 | INHERITED FROM: In phosphorus-containing anhydrides || Adenosinetriphosphatase |
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like | 0.01206 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.01958 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
56300,55816 56300 - Metallo-dependent phosphatases 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | INHERITED FROM: UDP-sugar diphosphatase || In phosphorus-containing anhydrides || Apyrase |
56784,81665 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.2644 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
47943,47353 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like | 0.58 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.9067 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.9283 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
47353,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0.9828 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
53098,46919 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 1 | INHERITED FROM: dUTP diphosphatase |
57756,50630 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase |
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
102860,54197 102860 - mRNA decapping enzyme DcpS N-terminal domain 54197 - HIT-like | 0 | Direct |
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52156 52540 - P-loop containing nucleoside triphosphate hydrolases 52156 - Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | Direct |
55608,56712 55608 - Homing endonucleases 56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
52540,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 54980 - EF-G C-terminal domain-like | 0 | Direct |
55811,55811 55811 - Nudix 55811 - Nudix | 0 | Direct |
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like | 0 | Direct |
52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | Direct |
100939,68906 100939 - SPOC domain-like 68906 - SAP domain | 0 | Direct |
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains | 0 | Direct |
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | Direct |
140586,55811 140586 - Dcp2 domain-like 55811 - Nudix | 0 | Direct |
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
101386,101386 101386 - all-alpha NTP pyrophosphatases 101386 - all-alpha NTP pyrophosphatases | 0 | Direct |
54980,54980 54980 - EF-G C-terminal domain-like 54980 - EF-G C-terminal domain-like | 0 | Direct |
101386,53720 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | Direct |
100939,101420 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80 | 0 | Direct |
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
-9,52540 -9 - PDB 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0 | Direct |
52540,-9 52540 - P-loop containing nucleoside triphosphate hydrolases -9 - PDB | 0 | Direct |
52156,50447 52156 - Initiation factor IF2/eIF5b, domain 3 50447 - Translation proteins | 0 | Direct |
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases | 0 | Direct |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
52540,-8 52540 - P-loop containing nucleoside triphosphate hydrolases -8 - ECOD | 0 | Direct |
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases | 0 | Direct |
46785,47819 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like | 0 | Direct |
52540,57756 52540 - P-loop containing nucleoside triphosphate hydrolases 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
141734,101386 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases | 0 | Direct |
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like | 0 | Direct |
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like | 0 | Direct |
53067,109604 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | Direct |
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
116846,52540 116846 - MIT domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50916,46785 50916 - Rap30/74 interaction domains 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47781,46929 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
160481,160481 160481 - BRK domain-like 160481 - BRK domain-like | 0 | Direct |
50249,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,49899 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
158702,81296 158702 - Sec63 N-terminal domain-like 81296 - E set domains | 0 | Direct |
56731,52540 56731 - DNA primase core 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | Direct |
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like | 0 | Direct |
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
158702,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
46785,158702 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like | 0 | Direct |
50447,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like | 0 | Direct |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51283,51283 51283 - dUTPase-like 51283 - dUTPase-like | 0 | Direct |
50249,47781 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like | 0 | Direct |
55464,52540 55464 - Origin of replication-binding domain, RBD-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53300,100939 53300 - vWA-like 100939 - SPOC domain-like | 0 | Direct |
52540,48403 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat | 0 | Direct |
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like | 0 | Direct |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | Direct |
48024,52540 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,54928 52540 - P-loop containing nucleoside triphosphate hydrolases 54928 - RNA-binding domain, RBD | 0 | Direct |
52540,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain | 0.0000000000003508 | Direct |
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000001872 | Direct |
57756,51283 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.00000000004607 | Direct |
51283,50630 51283 - dUTPase-like 50630 - Acid proteases | 0.00000000004607 | Direct |
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000007906 | Direct |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.000000005555 | Direct |
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like | 0.00000001137 | Direct |
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0.00000001137 | Direct |
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0.00000001137 | Direct |
51294,55608 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases | 0.00000003829 | Direct |
56712,51294 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0.000003274 | Direct |
53649,54060 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 0.000005345 | Direct |
90188,90188 90188 - Somatomedin B domain 90188 - Somatomedin B domain | 0.0000765 | Direct |
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.0000765 | Direct |
53098,51283 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.0000765 | Direct |
51283,46919 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | Direct |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.00009518 | Direct |
55608,52540 55608 - Homing endonucleases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0001909 | Direct |
-8,52540 -8 - ECOD 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001909 | Inherited |
56672,46919 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0.001909 | Inherited |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0.002681 | Inherited |
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like | 0.01206 | Inherited |
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.01958 | Inherited |
56300,55816 56300 - Metallo-dependent phosphatases 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | Inherited |
56784,81665 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.2644 | Inherited |
47943,47353 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like | 0.58 | Inherited |
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.9067 | Inherited |
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.9283 | Inherited |
47353,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0.9828 | Inherited |
53098,46919 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 1 | Inherited |
57756,50630 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 1 | Inherited |
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases | 1 | Inherited |
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
50630,56672,46919 50630 - Acid proteases 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
52540,52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | DIRECT |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
51197,52540,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
46785,158702,81296 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like 81296 - E set domains | 0 | DIRECT |
50447,54980,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
52540,48403,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
53300,100939,101420 53300 - vWA-like 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80 | 0 | DIRECT |
52540,52156,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 52156 - Initiation factor IF2/eIF5b, domain 3 50447 - Translation proteins | 0 | DIRECT |
53067,53067,109604 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | DIRECT |
52540,46785,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like | 0 | DIRECT |
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like | 0 | DIRECT |
52540,49899,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,54980,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 54980 - EF-G C-terminal domain-like 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
53300,100939,68906 53300 - vWA-like 100939 - SPOC domain-like 68906 - SAP domain | 0 | DIRECT |
52540,56712,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
52540,52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
50249,52540,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
48024,52540,51294 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
50249,47781,46929 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
46785,158702,52540 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
158702,52540,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | DIRECT |
141734,101386,53720 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | DIRECT |
52540,50447,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
52540,46785,158702 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like | 0 | DIRECT |
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | DIRECT |
52540,52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57756,51283,50630 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like 50630 - Acid proteases | 0.00000000004607 | DIRECT |
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0.00000001137 | DIRECT |
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0.00000001137 | DIRECT |
52540,51294,55608 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases | 0.00000006142 | DIRECT |
57756,57756,51283 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.0000006664 | DIRECT |
47353,57756,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.0000006664 | DIRECT |
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000003274 | DIRECT |
51283,50630,56672 51283 - dUTPase-like 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0.000003281 | DIRECT |
90188,53649,54060 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 0.000005345 | DIRECT |
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.0000765 | DIRECT |
51283,46919,53098 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.0000765 | DIRECT |
56672,53098,51283 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.0000765 | DIRECT |
53098,51283,46919 53098 - Ribonuclease H-like 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | DIRECT |
56672,46919,53098 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.001909 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.8824 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
47943,47353,57756 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0.9828 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
56672,53098,46919 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 1 | INHERITED FROM: dUTP diphosphatase |
47353,57756,50630 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase |
53098,46919,53098 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase |
57756,50630,56672 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases 56672 - DNA/RNA polymerases | 1 | INHERITED FROM: dUTP diphosphatase |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | Direct |
50630,56672,46919 50630 - Acid proteases 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
52540,52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | Direct |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
51197,52540,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
46785,158702,81296 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like 81296 - E set domains | 0 | Direct |
50447,54980,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like 54980 - EF-G C-terminal domain-like | 0 | Direct |
52540,48403,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
53300,100939,101420 53300 - vWA-like 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80 | 0 | Direct |
52540,52156,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 52156 - Initiation factor IF2/eIF5b, domain 3 50447 - Translation proteins | 0 | Direct |
53067,53067,109604 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | Direct |
52540,46785,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like | 0 | Direct |
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like | 0 | Direct |
52540,49899,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
52540,54980,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 54980 - EF-G C-terminal domain-like 54980 - EF-G C-terminal domain-like | 0 | Direct |
53300,100939,68906 53300 - vWA-like 100939 - SPOC domain-like 68906 - SAP domain | 0 | Direct |
52540,56712,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
52540,52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
50249,52540,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
48024,52540,51294 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
50249,47781,46929 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
46785,158702,52540 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
158702,52540,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | Direct |
141734,101386,53720 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | Direct |
52540,50447,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 54980 - EF-G C-terminal domain-like | 0 | Direct |
52540,46785,158702 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like | 0 | Direct |
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like | 0 | Direct |
52540,52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57756,51283,50630 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like 50630 - Acid proteases | 0.00000000004607 | Direct |
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like | 0.00000001137 | Direct |
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 | 0.00000001137 | Direct |
52540,51294,55608 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases | 0.00000006142 | Direct |
57756,57756,51283 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains 51283 - dUTPase-like | 0.0000006664 | Direct |
47353,57756,57756 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0.0000006664 | Direct |
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000003274 | Direct |
51283,50630,56672 51283 - dUTPase-like 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0.000003281 | Direct |
90188,53649,54060 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 0.000005345 | Direct |
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.0000765 | Direct |
51283,46919,53098 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.0000765 | Direct |
56672,53098,51283 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.0000765 | Direct |
53098,51283,46919 53098 - Ribonuclease H-like 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | Direct |
56672,46919,53098 56672 - DNA/RNA polymerases 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.001909 | Inherited |
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.8824 | Inherited |
47943,47353,57756 47943 - Retrovirus capsid protein, N-terminal core domain 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains | 0.9828 | Inherited |
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 1 | Inherited |
56672,53098,46919 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase | 1 | Inherited |
47353,57756,50630 47353 - Retrovirus capsid dimerization domain-like 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases | 1 | Inherited |
53098,46919,53098 53098 - Ribonuclease H-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 1 | Inherited |
57756,50630,56672 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases 56672 - DNA/RNA polymerases | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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