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Enzyme Commission (EC): Acting on acid anhydrides
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleic acid-binding proteins | 0 | DIRECT |
| "Winged helix" DNA-binding domain | 0 | DIRECT |
| Apyrase | 0 | DIRECT |
| EF-G C-terminal domain-like | 0 | DIRECT |
| C-terminal domain of Ku80 | 0 | DIRECT |
| RuvA domain 2-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Positive stranded ssRNA viruses | 0 | DIRECT |
| Nudix | 0 | DIRECT |
| mRNA decapping enzyme DcpS N-terminal domain | 0 | DIRECT |
| EndoU-like | 0 | DIRECT |
| Dcp2 domain-like | 0 | DIRECT |
| N-terminal domain of DnaB helicase | 0 | DIRECT |
| Acylphosphatase/BLUF domain-like | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| all-alpha NTP pyrophosphatases | 0 | DIRECT |
| ITPase-like | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| DHH phosphoesterases | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| DNA primase core | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Rap30/74 interaction domains | 0 | DIRECT |
| DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
| Inorganic pyrophosphatase | 0 | DIRECT |
| Origin of replication-binding domain, RBD-like | 0 | DIRECT |
| Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| dUTPase-like | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Trypsin-like serine proteases | 0.00000000000002806 | DIRECT |
| vWA-like | 0.0000000000001715 | DIRECT |
| Tudor/PWWP/MBT | 0.00000000007254 | DIRECT |
| HMA, heavy metal-associated domain | 0.0000000003308 | DIRECT |
| SAP domain | 0.000000007375 | DIRECT |
| Replicase NSP9 | 0.00000001504 | DIRECT |
| Coronavirus NSP10-like | 0.00000001504 | DIRECT |
| Coronavirus NSP8-like | 0.00000001504 | DIRECT |
| Coronavirus NSP7-like | 0.00000001504 | DIRECT |
| Prokaryotic type I DNA topoisomerase | 0.00000002077 | DIRECT |
| MIT domain | 0.00000003368 | DIRECT |
| SCOP hierarchy in SUPERFAMILY | 0.00000003907 | DIRECT |
| E set domains | 0.0000000759 | DIRECT |
| Homing endonucleases | 0.0000002979 | DIRECT |
| HRDC-like | 0.000001084 | DIRECT |
| Hedgehog/intein (Hint) domain | 0.00000149 | DIRECT |
| NSP3A-like | 0.000007894 | DIRECT |
| F-box domain | 0.00001953 | DIRECT |
| RNA-binding domain, RBD | 0.00007272 | DIRECT |
| Somatomedin B domain | 0.000095 | DIRECT |
| FYVE/PHD zinc finger | 0.000257 | DIRECT |
| R3H domain | 0.0005598 | DIRECT |
| CYTH-like phosphatases | 0.002048 | INHERITED FROM: Thiamine-triphosphatase || Triphosphatase || In phosphorus-containing anhydrides |
| Bromodomain | 0.002075 | INHERITED FROM: Adenosinetriphosphatase |
| His-Me finger endonucleases | 0.002095 | INHERITED FROM: Nucleotide diphosphatase || In phosphorus-containing anhydrides |
| post-AAA+ oligomerization domain-like | 0.003208 | INHERITED FROM: Adenosinetriphosphatase || In phosphorus-containing anhydrides |
| Ankyrin repeat | 0.003949 | INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase |
| WW domain | 0.01106 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
| SARS Nsp1-like | 0.01418 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
| Ribonuclease Rh-like | 0.01747 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase || In phosphorus-containing anhydrides |
| CCCH zinc finger | 0.06486 | INHERITED FROM: RNA helicase |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.07683 | INHERITED FROM: Apyrase || UDP-sugar diphosphatase || In phosphorus-containing anhydrides |
| Retrovirus zinc finger-like domains | 0.1237 | INHERITED FROM: dUTP diphosphatase || RNA helicase |
| ADC-like | 0.1738 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Vesicle-fusing ATPase |
| HD-domain/PDEase-like | 0.2032 | INHERITED FROM: Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Exopolyphosphatase || In phosphorus-containing anhydrides |
| UBA-like | 0.2173 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement |
| Calcium ATPase, transduction domain A | 0.2348 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Calcium ATPase, transmembrane domain M | 0.2379 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0.284 | INHERITED FROM: Undecaprenyl-diphosphate phosphatase || Dolichyldiphosphatase || In phosphorus-containing anhydrides |
| NTF2-like | 0.2943 | INHERITED FROM: RNA helicase |
| Actin-like ATPase domain | 0.4656 | INHERITED FROM: Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Non-chaperonin molecular chaperone ATPase || Adenosinetriphosphatase || Exopolyphosphatase || In phosphorus-containing anhydrides |
| Retrovirus capsid dimerization domain-like | 0.6318 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Clavaminate synthase-like | 0.6437 | INHERITED FROM: RNA helicase |
| HisI-like | 0.7675 | INHERITED FROM: Phosphoribosyl-ATP diphosphatase || In phosphorus-containing anhydrides |
| Retrovirus capsid protein, N-terminal core domain | 0.9467 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| N-terminal Zn binding domain of HIV integrase | 0.9795 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| PH domain-like | 1 | INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement |
| Cysteine proteinases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase || RNA helicase |
| Retroviral matrix proteins | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Alkaline phosphatase-like | 1 | INHERITED FROM: Nucleotide diphosphatase || Bis(5'-adenosyl)-triphosphatase |
| HAD-like | 1 | INHERITED FROM: Inorganic diphosphatase || Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase |
| SurE-like | 1 | INHERITED FROM: Exopolyphosphatase || In phosphorus-containing anhydrides |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | INHERITED FROM: Adenosinetriphosphatase |
| Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Macro domain-like | 1 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase |
| DNA-binding domain of retroviral integrase | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleic acid-binding proteins | 0 | Direct |
| "Winged helix" DNA-binding domain | 0 | Direct |
| Apyrase | 0 | Direct |
| EF-G C-terminal domain-like | 0 | Direct |
| C-terminal domain of Ku80 | 0 | Direct |
| RuvA domain 2-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Positive stranded ssRNA viruses | 0 | Direct |
| Nudix | 0 | Direct |
| mRNA decapping enzyme DcpS N-terminal domain | 0 | Direct |
| EndoU-like | 0 | Direct |
| Dcp2 domain-like | 0 | Direct |
| N-terminal domain of DnaB helicase | 0 | Direct |
| Acylphosphatase/BLUF domain-like | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| all-alpha NTP pyrophosphatases | 0 | Direct |
| ITPase-like | 0 | Direct |
| HIT-like | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| DHH phosphoesterases | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| DNA primase core | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Rap30/74 interaction domains | 0 | Direct |
| DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
| Inorganic pyrophosphatase | 0 | Direct |
| Origin of replication-binding domain, RBD-like | 0 | Direct |
| Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Translation proteins | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Metallo-dependent phosphatases | 0 | Direct |
| dUTPase-like | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Trypsin-like serine proteases | 0.00000000000002806 | Direct |
| vWA-like | 0.0000000000001715 | Direct |
| Tudor/PWWP/MBT | 0.00000000007254 | Direct |
| HMA, heavy metal-associated domain | 0.0000000003308 | Direct |
| SAP domain | 0.000000007375 | Direct |
| Replicase NSP9 | 0.00000001504 | Direct |
| Coronavirus NSP10-like | 0.00000001504 | Direct |
| Coronavirus NSP8-like | 0.00000001504 | Direct |
| Coronavirus NSP7-like | 0.00000001504 | Direct |
| Prokaryotic type I DNA topoisomerase | 0.00000002077 | Direct |
| MIT domain | 0.00000003368 | Direct |
| SCOP hierarchy in SUPERFAMILY | 0.00000003907 | Direct |
| E set domains | 0.0000000759 | Direct |
| Homing endonucleases | 0.0000002979 | Direct |
| HRDC-like | 0.000001084 | Direct |
| Hedgehog/intein (Hint) domain | 0.00000149 | Direct |
| NSP3A-like | 0.000007894 | Direct |
| F-box domain | 0.00001953 | Direct |
| RNA-binding domain, RBD | 0.00007272 | Direct |
| Somatomedin B domain | 0.000095 | Direct |
| FYVE/PHD zinc finger | 0.000257 | Direct |
| R3H domain | 0.0005598 | Direct |
| CYTH-like phosphatases | 0.002048 | Inherited |
| Bromodomain | 0.002075 | Inherited |
| His-Me finger endonucleases | 0.002095 | Inherited |
| post-AAA+ oligomerization domain-like | 0.003208 | Inherited |
| Ankyrin repeat | 0.003949 | Inherited |
| WW domain | 0.01106 | Inherited |
| SARS Nsp1-like | 0.01418 | Inherited |
| Ribonuclease Rh-like | 0.01747 | Inherited |
| CCCH zinc finger | 0.06486 | Inherited |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.07683 | Inherited |
| Retrovirus zinc finger-like domains | 0.1237 | Inherited |
| ADC-like | 0.1738 | Inherited |
| HD-domain/PDEase-like | 0.2032 | Inherited |
| UBA-like | 0.2173 | Inherited |
| Calcium ATPase, transduction domain A | 0.2348 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.2379 | Inherited |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0.284 | Inherited |
| NTF2-like | 0.2943 | Inherited |
| Actin-like ATPase domain | 0.4656 | Inherited |
| Retrovirus capsid dimerization domain-like | 0.6318 | Inherited |
| Clavaminate synthase-like | 0.6437 | Inherited |
| HisI-like | 0.7675 | Inherited |
| Retrovirus capsid protein, N-terminal core domain | 0.9467 | Inherited |
| N-terminal Zn binding domain of HIV integrase | 0.9795 | Inherited |
| PH domain-like | 1 | Inherited |
| Cysteine proteinases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Retroviral matrix proteins | 1 | Inherited |
| Alkaline phosphatase-like | 1 | Inherited |
| HAD-like | 1 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| SurE-like | 1 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | Inherited |
| Acid proteases | 1 | Inherited |
| Macro domain-like | 1 | Inherited |
| DNA-binding domain of retroviral integrase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| ITPase (Ham1) | 0 | DIRECT |
| Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 0 | DIRECT |
| Tandem AAA-ATPase domain | 0 | DIRECT |
| ADPRibase-Mn-like | 0 | DIRECT |
| HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | DIRECT |
| CDH-like | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Ppx/GppA phosphatase | 0 | DIRECT |
| Viral proteases | 0 | DIRECT |
| GUCT domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Viral cysteine protease of trypsin fold | 0 | DIRECT |
| Elongation factors | 0 | DIRECT |
| RecQ helicase DNA-binding domain-like | 0 | DIRECT |
| mRNA decapping enzyme DcpS C-terminal domain | 0 | DIRECT |
| mRNA decapping enzyme DcpS N-terminal domain | 0 | DIRECT |
| Apyrase | 0 | DIRECT |
| MgsA/YrvN C-terminal domain-like | 0 | DIRECT |
| Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
| FMDV leader protease | 0 | DIRECT |
| RNA helicase | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| Dcp2 box A domain | 0 | DIRECT |
| Ku70 subunit middle domain | 0 | DIRECT |
| Sec63 N-terminal domain | 0 | DIRECT |
| Nsp15 N-terminal domain-like | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| DNA-binding domain from rap30 | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Ku70 subunit N-terminal domain | 0 | DIRECT |
| C-terminal domain of Ku80 | 0 | DIRECT |
| Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| Replication initiation protein E1 | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| Class II viral fusion proteins C-terminal domain | 0 | DIRECT |
| Cdc48 N-terminal domain-like | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| HRDC domain from helicases | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Caliciviridae-like VP | 0 | DIRECT |
| Nsp15 C-terminal domain-like | 0 | DIRECT |
| G proteins | 0 | DIRECT |
| NADH pyrophosphatase | 0 | DIRECT |
| DNA helicase RuvA subunit, middle domain | 0 | DIRECT |
| Achaeal helicase C-terminal domain | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Helicase-like "domain" of reverse gyrase | 0 | DIRECT |
| mRNA decapping enzyme-like | 0 | DIRECT |
| DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
| Ppx associated domain | 0 | DIRECT |
| Ku80 subunit middle domain | 0 | DIRECT |
| MazG-like | 0 | DIRECT |
| RecG "wedge" domain | 0 | DIRECT |
| Macro domain | 0 | DIRECT |
| DNA helicase RuvA subunit, N-terminal domain | 0 | DIRECT |
| Helicase DNA-binding domain | 0 | DIRECT |
| Rap30/74 interaction domains | 0 | DIRECT |
| Maf-like | 0 | DIRECT |
| N-terminal domain of DnaB helicase | 0 | DIRECT |
| mRNA cap methylase | 0 | DIRECT |
| Inorganic pyrophosphatase | 0 | DIRECT |
| RNA-dependent RNA-polymerase | 0 | DIRECT |
| Acylphosphatase-like | 0 | DIRECT |
| TIP49 domain | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| dUTPase-like | 0 | DIRECT |
| Extended AAA-ATPase domain | 0 | DIRECT |
| Ku80 subunit N-terminal domain | 0 | DIRECT |
| HisE-like (PRA-PH) | 0 | DIRECT |
| EF-G/eEF-2 domains III and V | 0 | DIRECT |
| Manganese-dependent inorganic pyrophosphatase (family II) | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| CYTH domain | 0.000000000000001463 | DIRECT |
| Mason-Pfizer monkey virus matrix protein | 0.0000000000226 | DIRECT |
| HMA, heavy metal-associated domain | 0.000000000138 | DIRECT |
| SAP domain | 0.000000003152 | DIRECT |
| Coronavirus NSP7-like | 0.000000003491 | DIRECT |
| Coronavirus NSP10-like | 0.000000003491 | DIRECT |
| Coronavirus NSP8-like | 0.000000003491 | DIRECT |
| Replicase NSP9 | 0.000000003491 | DIRECT |
| MIT domain | 0.000000007073 | DIRECT |
| Prokaryotic type I DNA topoisomerase | 0.000000008891 | DIRECT |
| Tudor domain | 0.00000181 | DIRECT |
| NSP3A-like | 0.000002782 | DIRECT |
| Intein (protein splicing domain) | 0.000003518 | DIRECT |
| F-box domain | 0.00001364 | DIRECT |
| Somatomedin B domain | 0.0000513 | DIRECT |
| AlkB-like | 0.0001434 | DIRECT |
| Protein serine/threonine phosphatase | 0.0002872 | DIRECT |
| R3H domain | 0.000314 | DIRECT |
| Bromodomain | 0.001422 | INHERITED FROM: Adenosinetriphosphatase |
| PHD domain | 0.001544 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase |
| Ankyrin repeat | 0.002141 | INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase |
| WW domain | 0.007869 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
| SARS Nsp1-like | 0.009821 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
| Ribonuclease Rh-like | 0.01281 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase || In phosphorus-containing anhydrides |
| SPRY domain | 0.0148 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
| Pleckstrin-homology domain (PH domain) | 0.04578 | INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement |
| CCCH zinc finger | 0.05112 | INHERITED FROM: RNA helicase |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.05136 | INHERITED FROM: Apyrase || UDP-sugar diphosphatase || In phosphorus-containing anhydrides |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.05136 | INHERITED FROM: Apyrase || UDP-sugar diphosphatase || In phosphorus-containing anhydrides |
| Meta-cation ATPase, catalytic domain P | 0.05566 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Retrovirus zinc finger-like domains | 0.06424 | INHERITED FROM: dUTP diphosphatase || RNA helicase |
| NagD-like | 0.1225 | INHERITED FROM: Inorganic diphosphatase || In phosphorus-containing anhydrides |
| Calcium ATPase, transduction domain A | 0.23 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Canonical RBD | 0.2346 | INHERITED FROM: RNA helicase |
| Retrovirus capsid protein C-terminal domain | 0.487 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| HisI-like | 0.535 | INHERITED FROM: Phosphoribosyl-ATP diphosphatase || In phosphorus-containing anhydrides |
| beta-Phosphoglucomutase-like | 0.6067 | INHERITED FROM: Inorganic diphosphatase || In phosphorus-containing anhydrides |
| RecA protein-like (ATPase-domain) | 0.6588 | INHERITED FROM: Nucleoside-triphosphate phosphatase |
| Calcium ATPase, transmembrane domain M | 0.6916 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Retroviral protease (retropepsin) | 0.7122 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| L-histidinol dehydrogenase HisD | 0.779 | INHERITED FROM: Phosphoribosyl-ATP diphosphatase |
| Retrovirus capsid protein, N-terminal core domain | 0.7798 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| N-terminal Zn binding domain of HIV integrase | 0.8565 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| DNA-binding domain of retroviral integrase | 0.8843 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Ribonuclease H | 1 | INHERITED FROM: dUTP diphosphatase |
| Retroviral integrase, catalytic domain | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| SurE-like | 1 | INHERITED FROM: Exopolyphosphatase || In phosphorus-containing anhydrides |
| Reverse transcriptase | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| ITPase (Ham1) | 0 | Direct |
| Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 0 | Direct |
| Tandem AAA-ATPase domain | 0 | Direct |
| ADPRibase-Mn-like | 0 | Direct |
| HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | Direct |
| CDH-like | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Ppx/GppA phosphatase | 0 | Direct |
| Viral proteases | 0 | Direct |
| GUCT domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Viral cysteine protease of trypsin fold | 0 | Direct |
| Elongation factors | 0 | Direct |
| RecQ helicase DNA-binding domain-like | 0 | Direct |
| mRNA decapping enzyme DcpS C-terminal domain | 0 | Direct |
| mRNA decapping enzyme DcpS N-terminal domain | 0 | Direct |
| Apyrase | 0 | Direct |
| MgsA/YrvN C-terminal domain-like | 0 | Direct |
| Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
| FMDV leader protease | 0 | Direct |
| RNA helicase | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| Dcp2 box A domain | 0 | Direct |
| Ku70 subunit middle domain | 0 | Direct |
| Sec63 N-terminal domain | 0 | Direct |
| Nsp15 N-terminal domain-like | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| DNA-binding domain from rap30 | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Ku70 subunit N-terminal domain | 0 | Direct |
| C-terminal domain of Ku80 | 0 | Direct |
| Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| Replication initiation protein E1 | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| Class II viral fusion proteins C-terminal domain | 0 | Direct |
| Cdc48 N-terminal domain-like | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| HRDC domain from helicases | 0 | Direct |
| Chromo domain | 0 | Direct |
| Caliciviridae-like VP | 0 | Direct |
| Nsp15 C-terminal domain-like | 0 | Direct |
| G proteins | 0 | Direct |
| NADH pyrophosphatase | 0 | Direct |
| DNA helicase RuvA subunit, middle domain | 0 | Direct |
| Achaeal helicase C-terminal domain | 0 | Direct |
| MutT-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| Helicase-like "domain" of reverse gyrase | 0 | Direct |
| mRNA decapping enzyme-like | 0 | Direct |
| DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
| Ppx associated domain | 0 | Direct |
| Ku80 subunit middle domain | 0 | Direct |
| MazG-like | 0 | Direct |
| RecG "wedge" domain | 0 | Direct |
| Macro domain | 0 | Direct |
| DNA helicase RuvA subunit, N-terminal domain | 0 | Direct |
| Helicase DNA-binding domain | 0 | Direct |
| Rap30/74 interaction domains | 0 | Direct |
| Maf-like | 0 | Direct |
| N-terminal domain of DnaB helicase | 0 | Direct |
| mRNA cap methylase | 0 | Direct |
| Inorganic pyrophosphatase | 0 | Direct |
| RNA-dependent RNA-polymerase | 0 | Direct |
| Acylphosphatase-like | 0 | Direct |
| TIP49 domain | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| dUTPase-like | 0 | Direct |
| Extended AAA-ATPase domain | 0 | Direct |
| Ku80 subunit N-terminal domain | 0 | Direct |
| HisE-like (PRA-PH) | 0 | Direct |
| EF-G/eEF-2 domains III and V | 0 | Direct |
| Manganese-dependent inorganic pyrophosphatase (family II) | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| CYTH domain | 0.000000000000001463 | Direct |
| Mason-Pfizer monkey virus matrix protein | 0.0000000000226 | Direct |
| HMA, heavy metal-associated domain | 0.000000000138 | Direct |
| SAP domain | 0.000000003152 | Direct |
| Coronavirus NSP7-like | 0.000000003491 | Direct |
| Coronavirus NSP10-like | 0.000000003491 | Direct |
| Coronavirus NSP8-like | 0.000000003491 | Direct |
| Replicase NSP9 | 0.000000003491 | Direct |
| MIT domain | 0.000000007073 | Direct |
| Prokaryotic type I DNA topoisomerase | 0.000000008891 | Direct |
| Tudor domain | 0.00000181 | Direct |
| NSP3A-like | 0.000002782 | Direct |
| Intein (protein splicing domain) | 0.000003518 | Direct |
| F-box domain | 0.00001364 | Direct |
| Somatomedin B domain | 0.0000513 | Direct |
| AlkB-like | 0.0001434 | Direct |
| Protein serine/threonine phosphatase | 0.0002872 | Direct |
| R3H domain | 0.000314 | Direct |
| Bromodomain | 0.001422 | Inherited |
| PHD domain | 0.001544 | Inherited |
| Ankyrin repeat | 0.002141 | Inherited |
| WW domain | 0.007869 | Inherited |
| SARS Nsp1-like | 0.009821 | Inherited |
| Ribonuclease Rh-like | 0.01281 | Inherited |
| SPRY domain | 0.0148 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.04578 | Inherited |
| CCCH zinc finger | 0.05112 | Inherited |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.05136 | Inherited |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.05136 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.05566 | Inherited |
| Retrovirus zinc finger-like domains | 0.06424 | Inherited |
| NagD-like | 0.1225 | Inherited |
| Calcium ATPase, transduction domain A | 0.23 | Inherited |
| Canonical RBD | 0.2346 | Inherited |
| Retrovirus capsid protein C-terminal domain | 0.487 | Inherited |
| HisI-like | 0.535 | Inherited |
| beta-Phosphoglucomutase-like | 0.6067 | Inherited |
| RecA protein-like (ATPase-domain) | 0.6588 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.6916 | Inherited |
| Retroviral protease (retropepsin) | 0.7122 | Inherited |
| L-histidinol dehydrogenase HisD | 0.779 | Inherited |
| Retrovirus capsid protein, N-terminal core domain | 0.7798 | Inherited |
| N-terminal Zn binding domain of HIV integrase | 0.8565 | Inherited |
| DNA-binding domain of retroviral integrase | 0.8843 | Inherited |
| Ribonuclease H | 1 | Inherited |
| Retroviral integrase, catalytic domain | 1 | Inherited |
| SurE-like | 1 | Inherited |
| Reverse transcriptase | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| AN1-like Zinc finger | 0 | DIRECT |
| "Winged helix" DNA-binding domain | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| EF-G C-terminal domain-like | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Apyrase | 0 | DIRECT |
| Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| all-alpha NTP pyrophosphatases | 0 | DIRECT |
| DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Rap30/74 interaction domains | 0 | DIRECT |
| Dcp2 domain-like | 0 | DIRECT |
| DNA primase core | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| EndoU-like | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| mRNA decapping enzyme DcpS N-terminal domain | 0 | DIRECT |
| Nudix | 0 | DIRECT |
| Inorganic pyrophosphatase | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| N-terminal domain of DnaB helicase | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| DHH phosphoesterases | 0 | DIRECT |
| C-terminal domain of Ku80 | 0 | DIRECT |
| Acylphosphatase/BLUF domain-like | 0 | DIRECT |
| Nucleic acid-binding proteins | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| dUTPase-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Origin of replication-binding domain, RBD-like | 0 | DIRECT |
| Positive stranded ssRNA viruses | 0 | DIRECT |
| ITPase-like | 0 | DIRECT |
| RuvA domain 2-like | 0 | DIRECT |
| Trypsin-like serine proteases | 0.00000000000001978 | DIRECT |
| vWA-like | 0.0000000000001217 | DIRECT |
| Tudor/PWWP/MBT | 0.00000000005312 | DIRECT |
| HMA, heavy metal-associated domain | 0.0000000002445 | DIRECT |
| SAP domain | 0.000000005555 | DIRECT |
| Replicase NSP9 | 0.00000001137 | DIRECT |
| Coronavirus NSP8-like | 0.00000001137 | DIRECT |
| Coronavirus NSP10-like | 0.00000001137 | DIRECT |
| Coronavirus NSP7-like | 0.00000001137 | DIRECT |
| Prokaryotic type I DNA topoisomerase | 0.00000001573 | DIRECT |
| MIT domain | 0.00000002557 | DIRECT |
| E set domains | 0.00000005792 | DIRECT |
| Homing endonucleases | 0.0000002295 | DIRECT |
| HRDC-like | 0.000000844 | DIRECT |
| Hedgehog/intein (Hint) domain | 0.000001163 | DIRECT |
| NSP3A-like | 0.000006227 | DIRECT |
| F-box domain | 0.00001555 | DIRECT |
| RNA-binding domain, RBD | 0.00005837 | DIRECT |
| Somatomedin B domain | 0.0000765 | DIRECT |
| FYVE/PHD zinc finger | 0.0002089 | DIRECT |
| R3H domain | 0.0004584 | DIRECT |
| CYTH-like phosphatases | 0.001704 | INHERITED FROM: Thiamine-triphosphatase || Triphosphatase || In phosphorus-containing anhydrides |
| Bromodomain | 0.001727 | INHERITED FROM: Adenosinetriphosphatase |
| His-Me finger endonucleases | 0.001743 | INHERITED FROM: In phosphorus-containing anhydrides || Nucleotide diphosphatase |
| post-AAA+ oligomerization domain-like | 0.002681 | INHERITED FROM: In phosphorus-containing anhydrides || Adenosinetriphosphatase |
| Ankyrin repeat | 0.003305 | INHERITED FROM: NAD(+) diphosphatase || Adenosinetriphosphatase |
| WW domain | 0.00938 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
| SARS Nsp1-like | 0.01206 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
| Ribonuclease Rh-like | 0.0149 | INHERITED FROM: Nucleoside-triphosphate phosphatase || Acting on ATP; involved in cellular and subcellular movement || In phosphorus-containing anhydrides || RNA helicase |
| CCCH zinc finger | 0.05626 | INHERITED FROM: RNA helicase |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | INHERITED FROM: UDP-sugar diphosphatase || In phosphorus-containing anhydrides || Apyrase |
| Retrovirus zinc finger-like domains | 0.1082 | INHERITED FROM: dUTP diphosphatase || RNA helicase |
| ADC-like | 0.1534 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Vesicle-fusing ATPase |
| HD-domain/PDEase-like | 0.1802 | INHERITED FROM: In phosphorus-containing anhydrides || Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Exopolyphosphatase |
| UBA-like | 0.193 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement |
| Calcium ATPase, transduction domain A | 0.209 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Calcium ATPase, transmembrane domain M | 0.212 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0.2558 | INHERITED FROM: In phosphorus-containing anhydrides || Dolichyldiphosphatase || Undecaprenyl-diphosphate phosphatase |
| NTF2-like | 0.2653 | INHERITED FROM: RNA helicase |
| Actin-like ATPase domain | 0.4244 | INHERITED FROM: In phosphorus-containing anhydrides || Guanosine-5'-triphosphate,3'-diphosphate diphosphatase || Exopolyphosphatase || Non-chaperonin molecular chaperone ATPase || Adenosinetriphosphatase |
| Retrovirus capsid dimerization domain-like | 0.58 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Clavaminate synthase-like | 0.5909 | INHERITED FROM: RNA helicase |
| HisI-like | 0.7063 | INHERITED FROM: In phosphorus-containing anhydrides || Phosphoribosyl-ATP diphosphatase |
| Retrovirus capsid protein, N-terminal core domain | 0.8755 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| N-terminal Zn binding domain of HIV integrase | 0.9067 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| DNA-binding domain of retroviral integrase | 0.9283 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase |
| Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| PH domain-like | 1 | INHERITED FROM: Dynamin GTPase || Acting on GTP; involved in cellular and subcellular movement |
| Retroviral matrix proteins | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| SurE-like | 1 | INHERITED FROM: In phosphorus-containing anhydrides || Exopolyphosphatase |
| Cysteine proteinases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase |
| Macro domain-like | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase || Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
| HAD-like | 1 | INHERITED FROM: Inorganic diphosphatase || Acting on acid anhydrides; catalyzing transmembrane movement of substances |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | INHERITED FROM: Adenosinetriphosphatase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Nucleoside-triphosphate phosphatase || RNA helicase |
| Alkaline phosphatase-like | 1 | INHERITED FROM: Nucleotide diphosphatase || Bis(5'-adenosyl)-triphosphatase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| AN1-like Zinc finger | 0 | Direct |
| "Winged helix" DNA-binding domain | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| EF-G C-terminal domain-like | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Apyrase | 0 | Direct |
| Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| all-alpha NTP pyrophosphatases | 0 | Direct |
| DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Rap30/74 interaction domains | 0 | Direct |
| Dcp2 domain-like | 0 | Direct |
| DNA primase core | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| EndoU-like | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| mRNA decapping enzyme DcpS N-terminal domain | 0 | Direct |
| Nudix | 0 | Direct |
| Inorganic pyrophosphatase | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
| Metallo-dependent phosphatases | 0 | Direct |
| HIT-like | 0 | Direct |
| N-terminal domain of DnaB helicase | 0 | Direct |
| BRK domain-like | 0 | Direct |
| DHH phosphoesterases | 0 | Direct |
| C-terminal domain of Ku80 | 0 | Direct |
| Acylphosphatase/BLUF domain-like | 0 | Direct |
| Nucleic acid-binding proteins | 0 | Direct |
| Translation proteins | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| dUTPase-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Origin of replication-binding domain, RBD-like | 0 | Direct |
| Positive stranded ssRNA viruses | 0 | Direct |
| ITPase-like | 0 | Direct |
| RuvA domain 2-like | 0 | Direct |
| Trypsin-like serine proteases | 0.00000000000001978 | Direct |
| vWA-like | 0.0000000000001217 | Direct |
| Tudor/PWWP/MBT | 0.00000000005312 | Direct |
| HMA, heavy metal-associated domain | 0.0000000002445 | Direct |
| SAP domain | 0.000000005555 | Direct |
| Replicase NSP9 | 0.00000001137 | Direct |
| Coronavirus NSP8-like | 0.00000001137 | Direct |
| Coronavirus NSP10-like | 0.00000001137 | Direct |
| Coronavirus NSP7-like | 0.00000001137 | Direct |
| Prokaryotic type I DNA topoisomerase | 0.00000001573 | Direct |
| MIT domain | 0.00000002557 | Direct |
| E set domains | 0.00000005792 | Direct |
| Homing endonucleases | 0.0000002295 | Direct |
| HRDC-like | 0.000000844 | Direct |
| Hedgehog/intein (Hint) domain | 0.000001163 | Direct |
| NSP3A-like | 0.000006227 | Direct |
| F-box domain | 0.00001555 | Direct |
| RNA-binding domain, RBD | 0.00005837 | Direct |
| Somatomedin B domain | 0.0000765 | Direct |
| FYVE/PHD zinc finger | 0.0002089 | Direct |
| R3H domain | 0.0004584 | Direct |
| CYTH-like phosphatases | 0.001704 | Inherited |
| Bromodomain | 0.001727 | Inherited |
| His-Me finger endonucleases | 0.001743 | Inherited |
| post-AAA+ oligomerization domain-like | 0.002681 | Inherited |
| Ankyrin repeat | 0.003305 | Inherited |
| WW domain | 0.00938 | Inherited |
| SARS Nsp1-like | 0.01206 | Inherited |
| Ribonuclease Rh-like | 0.0149 | Inherited |
| CCCH zinc finger | 0.05626 | Inherited |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | Inherited |
| Retrovirus zinc finger-like domains | 0.1082 | Inherited |
| ADC-like | 0.1534 | Inherited |
| HD-domain/PDEase-like | 0.1802 | Inherited |
| UBA-like | 0.193 | Inherited |
| Calcium ATPase, transduction domain A | 0.209 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.212 | Inherited |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0.2558 | Inherited |
| NTF2-like | 0.2653 | Inherited |
| Actin-like ATPase domain | 0.4244 | Inherited |
| Retrovirus capsid dimerization domain-like | 0.58 | Inherited |
| Clavaminate synthase-like | 0.5909 | Inherited |
| HisI-like | 0.7063 | Inherited |
| Retrovirus capsid protein, N-terminal core domain | 0.8755 | Inherited |
| N-terminal Zn binding domain of HIV integrase | 0.9067 | Inherited |
| DNA-binding domain of retroviral integrase | 0.9283 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| Acid proteases | 1 | Inherited |
| PH domain-like | 1 | Inherited |
| Retroviral matrix proteins | 1 | Inherited |
| SurE-like | 1 | Inherited |
| Cysteine proteinases | 1 | Inherited |
| Macro domain-like | 1 | Inherited |
| HAD-like | 1 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Alkaline phosphatase-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
102860,54197
102860 - mRNA decapping enzyme DcpS N-terminal domain
54197 - HIT-like | 0 | DIRECT |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52156
52540 - P-loop containing nucleoside triphosphate hydrolases
52156 - Initiation factor IF2/eIF5b, domain 3 | 0 | DIRECT |
89043,50494
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55608,56712
55608 - Homing endonucleases
56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
52540,54980
52540 - P-loop containing nucleoside triphosphate hydrolases
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
55811,55811
55811 - Nudix
55811 - Nudix | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
52540,47370
52540 - P-loop containing nucleoside triphosphate hydrolases
47370 - Bromodomain | 0 | DIRECT |
100939,68906
100939 - SPOC domain-like
68906 - SAP domain | 0 | DIRECT |
49899,52540
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | DIRECT |
50494,56672
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
140586,55811
140586 - Dcp2 domain-like
55811 - Nudix | 0 | DIRECT |
56672,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
101386,101386
101386 - all-alpha NTP pyrophosphatases
101386 - all-alpha NTP pyrophosphatases | 0 | DIRECT |
54980,54980
54980 - EF-G C-terminal domain-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
100939,101420
100939 - SPOC domain-like
101420 - C-terminal domain of Ku80 | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
-9,52540
-9 - PDB
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | DIRECT |
52540,-9
52540 - P-loop containing nucleoside triphosphate hydrolases
-9 - PDB | 0 | DIRECT |
52156,50447
52156 - Initiation factor IF2/eIF5b, domain 3
50447 - Translation proteins | 0 | DIRECT |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
52540,-8
52540 - P-loop containing nucleoside triphosphate hydrolases
-8 - ECOD | 0 | DIRECT |
88633,50494
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases | 0 | DIRECT |
46785,47819
46785 - "Winged helix" DNA-binding domain
47819 - HRDC-like | 0 | DIRECT |
52540,57756
52540 - P-loop containing nucleoside triphosphate hydrolases
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0 | DIRECT |
53335,142877
53335 - S-adenosyl-L-methionine-dependent methyltransferases
142877 - EndoU-like | 0 | DIRECT |
56672,88633
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52540,47819
52540 - P-loop containing nucleoside triphosphate hydrolases
47819 - HRDC-like | 0 | DIRECT |
53067,109604
53067 - Actin-like ATPase domain
109604 - HD-domain/PDEase-like | 0 | DIRECT |
54001,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
116846,52540
116846 - MIT domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50916,46785
50916 - Rap30/74 interaction domains
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47781,46929
47781 - RuvA domain 2-like
46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
160481,160481
160481 - BRK domain-like
160481 - BRK domain-like | 0 | DIRECT |
50249,52540
50249 - Nucleic acid-binding proteins
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,49899
52540 - P-loop containing nucleoside triphosphate hydrolases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
158702,81296
158702 - Sec63 N-terminal domain-like
81296 - E set domains | 0 | DIRECT |
56731,52540
56731 - DNA primase core
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0 | DIRECT |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0 | DIRECT |
52540,89043
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
158702,52540
158702 - Sec63 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
46785,158702
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | DIRECT |
50447,54980
50447 - Translation proteins
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51283,51283
51283 - dUTPase-like
51283 - dUTPase-like | 0 | DIRECT |
50249,47781
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like | 0 | DIRECT |
55464,52540
55464 - Origin of replication-binding domain, RBD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53300,100939
53300 - vWA-like
100939 - SPOC domain-like | 0 | DIRECT |
52540,48403
52540 - P-loop containing nucleoside triphosphate hydrolases
48403 - Ankyrin repeat | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
48024,52540
48024 - N-terminal domain of DnaB helicase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,54928
52540 - P-loop containing nucleoside triphosphate hydrolases
54928 - RNA-binding domain, RBD | 0 | DIRECT |
52540,51294
52540 - P-loop containing nucleoside triphosphate hydrolases
51294 - Hedgehog/intein (Hint) domain | 0.0000000000003508 | DIRECT |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000001872 | DIRECT |
57756,51283
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.00000000004607 | DIRECT |
51283,50630
51283 - dUTPase-like
50630 - Acid proteases | 0.00000000004607 | DIRECT |
51197,52540
51197 - Clavaminate synthase-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000007906 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.000000005555 | DIRECT |
140367,143076
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like | 0.00000001137 | DIRECT |
143076,101816
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0.00000001137 | DIRECT |
101816,144246
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0.00000001137 | DIRECT |
51294,55608
51294 - Hedgehog/intein (Hint) domain
55608 - Homing endonucleases | 0.00000003829 | DIRECT |
56712,51294
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0.000003274 | DIRECT |
53649,54060
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0.000005345 | DIRECT |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0.0000765 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0.0000765 | DIRECT |
53098,51283
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0.0000765 | DIRECT |
51283,46919
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.00009518 | DIRECT |
55608,52540
55608 - Homing endonucleases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0001909 | DIRECT |
-8,52540
-8 - ECOD
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001909 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || RNA helicase |
56672,46919
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0.001909 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0.002681 | INHERITED FROM: In phosphorus-containing anhydrides || Adenosinetriphosphatase |
159936,52949
159936 - NSP3A-like
52949 - Macro domain-like | 0.01206 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
159936,53335
159936 - NSP3A-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.01958 | INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || DNA helicase || RNA helicase |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | INHERITED FROM: UDP-sugar diphosphatase || In phosphorus-containing anhydrides || Apyrase |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2644 | INHERITED FROM: Acting on acid anhydrides; catalyzing transmembrane movement of substances |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0.58 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0.9067 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0.9283 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0.9828 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 1 | INHERITED FROM: dUTP diphosphatase |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
102860,54197
102860 - mRNA decapping enzyme DcpS N-terminal domain
54197 - HIT-like | 0 | Direct |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52156
52540 - P-loop containing nucleoside triphosphate hydrolases
52156 - Initiation factor IF2/eIF5b, domain 3 | 0 | Direct |
89043,50494
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | Direct |
55608,56712
55608 - Homing endonucleases
56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
52540,54980
52540 - P-loop containing nucleoside triphosphate hydrolases
54980 - EF-G C-terminal domain-like | 0 | Direct |
55811,55811
55811 - Nudix
55811 - Nudix | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
52540,47370
52540 - P-loop containing nucleoside triphosphate hydrolases
47370 - Bromodomain | 0 | Direct |
100939,68906
100939 - SPOC domain-like
68906 - SAP domain | 0 | Direct |
49899,52540
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | Direct |
50494,56672
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | Direct |
140586,55811
140586 - Dcp2 domain-like
55811 - Nudix | 0 | Direct |
56672,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
101386,101386
101386 - all-alpha NTP pyrophosphatases
101386 - all-alpha NTP pyrophosphatases | 0 | Direct |
54980,54980
54980 - EF-G C-terminal domain-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
101386,53720
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
100939,101420
100939 - SPOC domain-like
101420 - C-terminal domain of Ku80 | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
-9,52540
-9 - PDB
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | Direct |
52540,-9
52540 - P-loop containing nucleoside triphosphate hydrolases
-9 - PDB | 0 | Direct |
52156,50447
52156 - Initiation factor IF2/eIF5b, domain 3
50447 - Translation proteins | 0 | Direct |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | Direct |
52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
52540,-8
52540 - P-loop containing nucleoside triphosphate hydrolases
-8 - ECOD | 0 | Direct |
88633,50494
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases | 0 | Direct |
46785,47819
46785 - "Winged helix" DNA-binding domain
47819 - HRDC-like | 0 | Direct |
52540,57756
52540 - P-loop containing nucleoside triphosphate hydrolases
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
141734,101386
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases | 0 | Direct |
53335,142877
53335 - S-adenosyl-L-methionine-dependent methyltransferases
142877 - EndoU-like | 0 | Direct |
56672,88633
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
52540,47819
52540 - P-loop containing nucleoside triphosphate hydrolases
47819 - HRDC-like | 0 | Direct |
53067,109604
53067 - Actin-like ATPase domain
109604 - HD-domain/PDEase-like | 0 | Direct |
54001,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
116846,52540
116846 - MIT domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50916,46785
50916 - Rap30/74 interaction domains
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47781,46929
47781 - RuvA domain 2-like
46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
160481,160481
160481 - BRK domain-like
160481 - BRK domain-like | 0 | Direct |
50249,52540
50249 - Nucleic acid-binding proteins
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,49899
52540 - P-loop containing nucleoside triphosphate hydrolases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
158702,81296
158702 - Sec63 N-terminal domain-like
81296 - E set domains | 0 | Direct |
56731,52540
56731 - DNA primase core
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0 | Direct |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0 | Direct |
52540,89043
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
158702,52540
158702 - Sec63 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
46785,158702
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | Direct |
50447,54980
50447 - Translation proteins
54980 - EF-G C-terminal domain-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51283,51283
51283 - dUTPase-like
51283 - dUTPase-like | 0 | Direct |
50249,47781
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like | 0 | Direct |
55464,52540
55464 - Origin of replication-binding domain, RBD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53300,100939
53300 - vWA-like
100939 - SPOC domain-like | 0 | Direct |
52540,48403
52540 - P-loop containing nucleoside triphosphate hydrolases
48403 - Ankyrin repeat | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
48024,52540
48024 - N-terminal domain of DnaB helicase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,54928
52540 - P-loop containing nucleoside triphosphate hydrolases
54928 - RNA-binding domain, RBD | 0 | Direct |
52540,51294
52540 - P-loop containing nucleoside triphosphate hydrolases
51294 - Hedgehog/intein (Hint) domain | 0.0000000000003508 | Direct |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000001872 | Direct |
57756,51283
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.00000000004607 | Direct |
51283,50630
51283 - dUTPase-like
50630 - Acid proteases | 0.00000000004607 | Direct |
51197,52540
51197 - Clavaminate synthase-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00000000007906 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.000000005555 | Direct |
140367,143076
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like | 0.00000001137 | Direct |
143076,101816
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0.00000001137 | Direct |
101816,144246
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0.00000001137 | Direct |
51294,55608
51294 - Hedgehog/intein (Hint) domain
55608 - Homing endonucleases | 0.00000003829 | Direct |
56712,51294
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0.000003274 | Direct |
53649,54060
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0.000005345 | Direct |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0.0000765 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0.0000765 | Direct |
53098,51283
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0.0000765 | Direct |
51283,46919
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.00009518 | Direct |
55608,52540
55608 - Homing endonucleases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0001909 | Direct |
-8,52540
-8 - ECOD
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001909 | Inherited |
56672,46919
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0.001909 | Inherited |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0.002681 | Inherited |
159936,52949
159936 - NSP3A-like
52949 - Macro domain-like | 0.01206 | Inherited |
159936,53335
159936 - NSP3A-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.01958 | Inherited |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.06675 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2644 | Inherited |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0.58 | Inherited |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0.9067 | Inherited |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0.9283 | Inherited |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0.9828 | Inherited |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 1 | Inherited |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 1 | Inherited |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 1 | Inherited |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
50630,56672,46919
50630 - Acid proteases
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
52540,52540,47370
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
47370 - Bromodomain | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,52540,89043
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51197,52540,56672
51197 - Clavaminate synthase-like
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | DIRECT |
51197,52540,52540
51197 - Clavaminate synthase-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
46785,158702,81296
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like
81296 - E set domains | 0 | DIRECT |
50447,54980,54980
50447 - Translation proteins
54980 - EF-G C-terminal domain-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
52540,48403,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56672,52540,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,56672,88633
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
53300,100939,101420
53300 - vWA-like
100939 - SPOC domain-like
101420 - C-terminal domain of Ku80 | 0 | DIRECT |
52540,52156,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
52156 - Initiation factor IF2/eIF5b, domain 3
50447 - Translation proteins | 0 | DIRECT |
53067,53067,109604
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
109604 - HD-domain/PDEase-like | 0 | DIRECT |
52540,46785,47819
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain
47819 - HRDC-like | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
88633,50494,52540
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540,47819
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
47819 - HRDC-like | 0 | DIRECT |
52540,49899,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50494,52540,56672
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,54980,54980
52540 - P-loop containing nucleoside triphosphate hydrolases
54980 - EF-G C-terminal domain-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
53300,100939,68906
53300 - vWA-like
100939 - SPOC domain-like
68906 - SAP domain | 0 | DIRECT |
52540,56712,51294
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
50249,52540,52540
50249 - Nucleic acid-binding proteins
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
88633,88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
48024,52540,51294
48024 - N-terminal domain of DnaB helicase
52540 - P-loop containing nucleoside triphosphate hydrolases
51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
50249,47781,46929
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like
46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | DIRECT |
46785,158702,52540
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
158702,52540,52540
158702 - Sec63 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,89043,50494
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | DIRECT |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | DIRECT |
52540,50447,54980
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
52540,46785,158702
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | DIRECT |
54001,88633,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52540,52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0 | DIRECT |
52540,52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57756,51283,50630
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like
50630 - Acid proteases | 0.00000000004607 | DIRECT |
143076,101816,144246
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0.00000001137 | DIRECT |
140367,143076,101816
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0.00000001137 | DIRECT |
52540,51294,55608
52540 - P-loop containing nucleoside triphosphate hydrolases
51294 - Hedgehog/intein (Hint) domain
55608 - Homing endonucleases | 0.00000006142 | DIRECT |
57756,57756,51283
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.0000006664 | DIRECT |
47353,57756,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.0000006664 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000003274 | DIRECT |
51283,50630,56672
51283 - dUTPase-like
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0.000003281 | DIRECT |
90188,53649,54060
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0.000005345 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0.0000765 | DIRECT |
51283,46919,53098
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0.0000765 | DIRECT |
56672,53098,51283
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0.0000765 | DIRECT |
53098,51283,46919
53098 - Ribonuclease H-like
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | DIRECT |
56672,46919,53098
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0.001909 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0.8824 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0.9828 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase || In phosphorus-containing anhydrides |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 1 | INHERITED FROM: dUTP diphosphatase |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 1 | INHERITED FROM: dUTP diphosphatase |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 1 | INHERITED FROM: dUTP diphosphatase |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 1 | INHERITED FROM: dUTP diphosphatase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | Direct |
50630,56672,46919
50630 - Acid proteases
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
52540,52540,47370
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
47370 - Bromodomain | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,52540,89043
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51197,52540,56672
51197 - Clavaminate synthase-like
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | Direct |
51197,52540,52540
51197 - Clavaminate synthase-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
46785,158702,81296
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like
81296 - E set domains | 0 | Direct |
50447,54980,54980
50447 - Translation proteins
54980 - EF-G C-terminal domain-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
52540,48403,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56672,52540,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,56672,88633
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
53300,100939,101420
53300 - vWA-like
100939 - SPOC domain-like
101420 - C-terminal domain of Ku80 | 0 | Direct |
52540,52156,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
52156 - Initiation factor IF2/eIF5b, domain 3
50447 - Translation proteins | 0 | Direct |
53067,53067,109604
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
109604 - HD-domain/PDEase-like | 0 | Direct |
52540,46785,47819
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain
47819 - HRDC-like | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
88633,50494,52540
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540,47819
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
47819 - HRDC-like | 0 | Direct |
52540,49899,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50494,52540,56672
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | Direct |
52540,54980,54980
52540 - P-loop containing nucleoside triphosphate hydrolases
54980 - EF-G C-terminal domain-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
53300,100939,68906
53300 - vWA-like
100939 - SPOC domain-like
68906 - SAP domain | 0 | Direct |
52540,56712,51294
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
50249,52540,52540
50249 - Nucleic acid-binding proteins
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
88633,88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
48024,52540,51294
48024 - N-terminal domain of DnaB helicase
52540 - P-loop containing nucleoside triphosphate hydrolases
51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
50249,47781,46929
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like
46929 - DNA helicase RuvA subunit, C-terminal domain | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | Direct |
46785,158702,52540
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
158702,52540,52540
158702 - Sec63 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,89043,50494
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | Direct |
141734,101386,53720
141734 - HisI-like
101386 - all-alpha NTP pyrophosphatases
53720 - ALDH-like | 0 | Direct |
52540,50447,54980
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
54980 - EF-G C-terminal domain-like | 0 | Direct |
52540,46785,158702
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | Direct |
54001,88633,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
52540,52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0 | Direct |
52540,52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57756,51283,50630
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like
50630 - Acid proteases | 0.00000000004607 | Direct |
143076,101816,144246
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0.00000001137 | Direct |
140367,143076,101816
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0.00000001137 | Direct |
52540,51294,55608
52540 - P-loop containing nucleoside triphosphate hydrolases
51294 - Hedgehog/intein (Hint) domain
55608 - Homing endonucleases | 0.00000006142 | Direct |
57756,57756,51283
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains
51283 - dUTPase-like | 0.0000006664 | Direct |
47353,57756,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0.0000006664 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000003274 | Direct |
51283,50630,56672
51283 - dUTPase-like
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0.000003281 | Direct |
90188,53649,54060
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0.000005345 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0.0000765 | Direct |
51283,46919,53098
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0.0000765 | Direct |
56672,53098,51283
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0.0000765 | Direct |
53098,51283,46919
53098 - Ribonuclease H-like
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0.0000765 | Direct |
56672,46919,53098
56672 - DNA/RNA polymerases
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0.001909 | Inherited |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0.8824 | Inherited |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0.9828 | Inherited |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 1 | Inherited |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 1 | Inherited |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 1 | Inherited |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 1 | Inherited |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 1 | Inherited |
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