Enzyme Commission (EC): Acting on ATP; involved in cellular and subcellular movement

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: root [root] <7>

+ + 2: Hydrolases [3] <13> (396|669) (395|421|209)

+ 1: Acting on acid anhydrides [3.6] <5> (99|125) (98|99|65)

0: Acting on ATP; involved in cellular and subcellular movement [3.6.4] <13> (57|70) (56|60|32)

- 1: DNA helicase [3.6.4.12] (30|39) (30|30|16)

- 1: Deleted entry [3.6.4.11] (0|0) (0|0|0)

- 1: Non-chaperonin molecular chaperone ATPase [3.6.4.10] (3|3) (3|3|2)

- 1: Peroxisome-assembly ATPase [3.6.4.7] (0|0) (0|0|0)

- 1: RNA helicase [3.6.4.13] (27|33) (27|26|9)

- 1: Transferred entry: 5.6.1.1 [3.6.4.3] (0|0) (0|0|0)

- 1: Transferred entry: 5.6.1.2 [3.6.4.2] (0|0) (0|0|0)

- 1: Transferred entry: 5.6.1.3 [3.6.4.4] (0|0) (0|0|0)

- 1: Transferred entry: 5.6.1.4 [3.6.4.5] (0|0) (0|0|0)

- 1: Transferred entry: 5.6.1.5 [3.6.4.8] (0|0) (0|0|0)

- 1: Transferred entry: 5.6.1.7 [3.6.4.9] (0|0) (0|0|0)

- 1: Transferred entry: 5.6.1.8 [3.6.4.1] (0|0) (0|0|0)

- 1: Vesicle-fusing ATPase [3.6.4.6] (3|4) (3|4|2)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nucleic acid-binding proteins	0	Direct
"Winged helix" DNA-binding domain	0	Direct
C-terminal domain of Ku80	0	Direct
RuvA domain 2-like	0	Direct
vWA-like	0	Direct
Replicase NSP9	0	Direct
EndoU-like	0	Direct
N-terminal domain of DnaB helicase	0	Direct
Restriction endonuclease-like	0	Direct
Flavivirus capsid protein C	0	Direct
SPOC domain-like	0	Direct
Viral leader polypeptide zinc finger	0	Direct
E set domains	0	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0	Direct
Chromo domain-like	0	Direct
DNA primase core	0	Direct
Cdc48 domain 2-like	0	Direct
Macro domain-like	0	Direct
Coronavirus NSP10-like	0	Direct
Coronavirus NSP8-like	0	Direct
Sec63 N-terminal domain-like	0	Direct
Rap30/74 interaction domains	0	Direct
DNA helicase RuvA subunit, C-terminal domain	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
HRDC-like	0	Direct
Origin of replication-binding domain, RBD-like	0	Direct
AN1-like Zinc finger	0	Direct
NSP3A-like	0	Direct
Viral glycoprotein, central and dimerisation domains	0	Direct
Coronavirus NSP7-like	0	Direct
Tudor/PWWP/MBT	0	Direct
BRK domain-like	0	Direct
Prokaryotic type I DNA topoisomerase	0.0000000000004327	Direct
SAP domain	0.0000000000006622	Direct
Hedgehog/intein (Hint) domain	0.000000000001444	Direct
R3H domain	0.000000000003337	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.00000000001425	Direct
DNA/RNA polymerases	0.00000000001436	Direct
MIT domain	0.0000000000907	Direct
Homing endonucleases	0.0000000003267	Direct
RNA-binding domain, RBD	0.000000002137	Direct
FYVE/PHD zinc finger	0.0000001762	Direct
SARS Nsp1-like	0.0000003998	Direct
F-box domain	0.000001695	Direct
UBA-like	0.000006989	Direct
SCOP hierarchy in SUPERFAMILY	0.00001056	Direct
ADC-like	0.00013	Direct
WW domain	0.000344	Direct
Ribonuclease Rh-like	0.0008696	Direct
Trypsin-like serine proteases	0.00227	Inherited
CCCH zinc finger	0.008801	Inherited
NTF2-like	0.02812	Inherited
Clavaminate synthase-like	0.04056	Inherited
Retrovirus zinc finger-like domains	0.9989	Inherited
S-adenosyl-L-methionine-dependent methyltransferases	1	Inherited
Positive stranded ssRNA viruses	1	Inherited
Actin-like ATPase domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Heat shock protein 70kD (HSP70), peptide-binding domain	0	Direct
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain	0	Direct
Tandem AAA-ATPase domain	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Viral proteases	0	Direct
GUCT domain	0	Direct
BRK domain-like	0	Direct
RecQ helicase DNA-binding domain-like	0	Direct
NSP3A-like	0	Direct
RNA helicase	0	Direct
Sec63 C-terminal domain-like	0	Direct
Ku70 subunit middle domain	0	Direct
Sec63 N-terminal domain	0	Direct
Nsp15 N-terminal domain-like	0	Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	Direct
Viral glycoprotein, central and dimerisation domains	0	Direct
Coronavirus NSP7-like	0	Direct
DNA-binding domain from rap30	0	Direct
AN1-like Zinc finger	0	Direct
Ku70 subunit N-terminal domain	0	Direct
C-terminal domain of Ku80	0	Direct
Replication initiation protein E1	0	Direct
Class II viral fusion proteins C-terminal domain	0	Direct
Cdc48 N-terminal domain-like	0	Direct
Flavivirus capsid protein C	0	Direct
HRDC domain from helicases	0	Direct
Chromo domain	0	Direct
Nsp15 C-terminal domain-like	0	Direct
Coronavirus NSP10-like	0	Direct
DNA helicase RuvA subunit, middle domain	0	Direct
Achaeal helicase C-terminal domain	0	Direct
NTF2-like	0	Direct
Helicase-like "domain" of reverse gyrase	0	Direct
Coronavirus NSP8-like	0	Direct
DNA helicase RuvA subunit, C-terminal domain	0	Direct
Ku80 subunit middle domain	0	Direct
RecG "wedge" domain	0	Direct
Macro domain	0	Direct
DNA helicase RuvA subunit, N-terminal domain	0	Direct
Helicase DNA-binding domain	0	Direct
Rap30/74 interaction domains	0	Direct
N-terminal domain of DnaB helicase	0	Direct
mRNA cap methylase	0	Direct
TIP49 domain	0	Direct
Viral leader polypeptide zinc finger	0	Direct
Extended AAA-ATPase domain	0	Direct
Ku80 subunit N-terminal domain	0	Direct
Replicase NSP9	0	Direct
Cdc48 domain 2-like	0	Direct
Tudor domain	7.357e-16	Direct
Prokaryotic type I DNA topoisomerase	0.0000000000001532	Direct
SAP domain	0.0000000000003051	Direct
R3H domain	0.000000000001725	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.000000000008739	Direct
MIT domain	0.00000000001694	Direct
Intein (protein splicing domain)	0.000000004254	Direct
Actin/HSP70	0.00000002089	Direct
SARS Nsp1-like	0.0000002577	Direct
F-box domain	0.000001147	Direct
AlkB-like	0.000002634	Direct
PHD domain	0.00001485	Direct
SPRY domain	0.0001547	Direct
WW domain	0.0002221	Direct
Ribonuclease Rh-like	0.0005851	Direct
CCCH zinc finger	0.006535	Inherited
Canonical RBD	0.01106	Inherited
RNA-dependent RNA-polymerase	0.267	Inherited
Retrovirus zinc finger-like domains	0.9338	Inherited
Viral cysteine protease of trypsin fold	1	Inherited
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)	1	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
AN1-like Zinc finger	0	Direct
"Winged helix" DNA-binding domain	0	Direct
Flavivirus capsid protein C	0	Direct
Sec63 N-terminal domain-like	0	Direct
Viral leader polypeptide zinc finger	0	Direct
E set domains	0	Direct
Restriction endonuclease-like	0	Direct
Cdc48 domain 2-like	0	Direct
Replicase NSP9	0	Direct
Tudor/PWWP/MBT	0	Direct
DNA helicase RuvA subunit, C-terminal domain	0	Direct
Coronavirus NSP8-like	0	Direct
Coronavirus NSP10-like	0	Direct
SPOC domain-like	0	Direct
Rap30/74 interaction domains	0	Direct
DNA primase core	0	Direct
EndoU-like	0	Direct
Chromo domain-like	0	Direct
Coronavirus NSP7-like	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
N-terminal domain of DnaB helicase	0	Direct
HRDC-like	0	Direct
BRK domain-like	0	Direct
C-terminal domain of Ku80	0	Direct
Nucleic acid-binding proteins	0	Direct
Macro domain-like	0	Direct
Viral glycoprotein, central and dimerisation domains	0	Direct
NSP3A-like	0	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0	Direct
Origin of replication-binding domain, RBD-like	0	Direct
vWA-like	0	Direct
RuvA domain 2-like	0	Direct
Prokaryotic type I DNA topoisomerase	0.0000000000003091	Direct
SAP domain	0.0000000000004736	Direct
Hedgehog/intein (Hint) domain	0.000000000001037	Direct
R3H domain	0.000000000002402	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.00000000001032	Direct
DNA/RNA polymerases	0.00000000001041	Direct
MIT domain	0.00000000006659	Direct
Homing endonucleases	0.0000000002414	Direct
RNA-binding domain, RBD	0.000000001597	Direct
FYVE/PHD zinc finger	0.0000001352	Direct
SARS Nsp1-like	0.0000003089	Direct
F-box domain	0.000001327	Direct
UBA-like	0.000005505	Direct
ADC-like	0.000105	Direct
WW domain	0.00028	Direct
Ribonuclease Rh-like	0.0007158	Direct
Trypsin-like serine proteases	0.00189	Inherited
CCCH zinc finger	0.00744	Inherited
NTF2-like	0.02412	Inherited
Clavaminate synthase-like	0.03489	Inherited
Retrovirus zinc finger-like domains	0.9251	Inherited
Actin-like ATPase domain	1	Inherited
S-adenosyl-L-methionine-dependent methyltransferases	1	Inherited
Positive stranded ssRNA viruses	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55608,56712 55608 - Homing endonucleases 56712 - Prokaryotic type I DNA topoisomerase	0	Direct
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	Direct
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	Direct
100939,68906 100939 - SPOC domain-like 68906 - SAP domain	0	Direct
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains	0	Direct
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like	0	Direct
100939,101420 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80	0	Direct
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	Direct
-9,52540 -9 - PDB 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,-9 52540 - P-loop containing nucleoside triphosphate hydrolases -9 - PDB	0	Direct
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases	0	Direct
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	Direct
52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase	0	Direct
52540,-8 52540 - P-loop containing nucleoside triphosphate hydrolases -8 - ECOD	0	Direct
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	Direct
46785,47819 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like	0	Direct
52540,57756 52540 - P-loop containing nucleoside triphosphate hydrolases 57756 - Retrovirus zinc finger-like domains	0	Direct
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like	0	Direct
52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like	0	Direct
116846,52540 116846 - MIT domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50916,46785 50916 - Rap30/74 interaction domains 46785 - "Winged helix" DNA-binding domain	0	Direct
47781,46929 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain	0	Direct
160481,160481 160481 - BRK domain-like 160481 - BRK domain-like	0	Direct
50249,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,49899 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
158702,81296 158702 - Sec63 N-terminal domain-like 81296 - E set domains	0	Direct
56731,52540 56731 - DNA primase core 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	Direct
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like	0	Direct
158702,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
46785,158702 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50249,47781 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like	0	Direct
55464,52540 55464 - Origin of replication-binding domain, RBD-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53300,100939 53300 - vWA-like 100939 - SPOC domain-like	0	Direct
52540,48403 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat	0	Direct
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
48024,52540 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,54928 52540 - P-loop containing nucleoside triphosphate hydrolases 54928 - RNA-binding domain, RBD	0	Direct
52540,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain	1.78e-16	Direct
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0.0000000000003263	Direct
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0.000000000000555	Direct
51294,55608 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases	0.0000000001732	Direct
-8,52540 -8 - ECOD 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0000002745	Direct
56712,51294 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain	0.0000002745	Direct
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like	0.0000003089	Direct
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0.000003864	Direct
55608,52540 55608 - Homing endonucleases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00001707	Direct
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00002862	Direct
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0.48	Inherited
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0.9854	Inherited
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases	1	Inherited
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	1	Inherited
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses	1	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	Direct
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	Direct
51197,52540,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
46785,158702,81296 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like 81296 - E set domains	0	Direct
52540,48403,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	Direct
53300,100939,101420 53300 - vWA-like 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80	0	Direct
52540,46785,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like	0	Direct
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like	0	Direct
52540,49899,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53300,100939,68906 53300 - vWA-like 100939 - SPOC domain-like 68906 - SAP domain	0	Direct
52540,56712,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain	0	Direct
52540,52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	Direct
50249,52540,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48024,52540,51294 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain	0	Direct
50249,47781,46929 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain	0	Direct
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	Direct
46785,158702,52540 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
158702,52540,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,46785,158702 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like	0	Direct
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	Direct
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	Direct
52540,52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase	0	Direct
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
52540,51294,55608 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases	0.0000000008533	Direct
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0000002745	Direct

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Enzyme Commission (EC): Acting on ATP; involved in cellular and subcellular movement

Superfamily

Family

Supra-domain (including individual superfamily)