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Enzyme Commission (EC): Lyases
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PCD-like | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| Ribonuclease Rh-like | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| RNase A-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
| Lysozyme-like | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| RraA-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Chondroitin AC/alginate lyase | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| Indigoidine synthase A-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| MK0786-like | 0 | DIRECT |
| UbiD C-terminal domain-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| NosL/MerB-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Chelatase | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| Chlorophyll a-b binding protein | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| FAH | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| IpsF-like | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Adenylylcyclase toxin (the edema factor) | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| IlvD/EDD N-terminal domain-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| Gamma-glutamyl cyclotransferase-like | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| Molybdenum cofactor biosynthesis protein C, MoaC | 0 | DIRECT |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| Periplasmic binding protein-like I | 0 | DIRECT |
| AttH-like | 0 | DIRECT |
| Prokaryotic type KH domain (KH-domain type II) | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0.00000000000001193 | DIRECT |
| Xylose isomerase-like | 0.000000000000217 | DIRECT |
| UraD-Like | 0.000000000005654 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0.00000000006387 | DIRECT |
| CoaB-like | 0.0000000001962 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000001051 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000003987 | DIRECT |
| ClpP/crotonase | 0.000000004047 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0000002445 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.000000314 | DIRECT |
| Methylglyoxal synthase-like | 0.0000009252 | DIRECT |
| SIS domain | 0.000001238 | DIRECT |
| Electron transport accessory proteins | 0.000001701 | DIRECT |
| YjeF N-terminal domain-like | 0.000008302 | DIRECT |
| TATA-box binding protein-like | 0.000008711 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.000008711 | DIRECT |
| Starch-binding domain-like | 0.00002781 | DIRECT |
| Chorismate mutase II | 0.00003265 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.00006968 | DIRECT |
| Serine metabolism enzymes domain | 0.0001414 | DIRECT |
| PHM/PNGase F | 0.0001721 | DIRECT |
| Periplasmic binding protein-like II | 0.0006624 | DIRECT |
| RmlC-like cupins | 0.002675 | INHERITED FROM: Oxalate decarboxylase || Carbon-nitrogen lyases || Ureidoglycolate lyase || Ectoine synthase || Peptidyl-glutamate 4-carboxylase || Lyases acting on amides, amidines, etc || Hydro-lyases || Dimethylpropiothetin dethiomethylase |
| MAPEG domain-like | 0.005452 | INHERITED FROM: Leukotriene-C(4) synthase || Carbon-sulfur lyases |
| Barwin-like endoglucanases | 0.005644 | INHERITED FROM: Peptidoglycan lytic exotransglycosylase || Acting on polysaccharides || Carbon-oxygen lyases |
| Tautomerase/MIF | 0.006449 | INHERITED FROM: Carbon-carbon lyases || D-dopachrome decarboxylase || Carboxy-lyases |
| HSP20-like chaperones | 0.007354 | INHERITED FROM: Carbon-oxygen lyases || Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase || Hydro-lyases |
| Calcium-dependent phosphotriesterase | 0.0207 | INHERITED FROM: Peptidylamidoglycolate lyase || Strictosidine synthase || Carbon-nitrogen lyases |
| DAK1/DegV-like | 0.02264 | INHERITED FROM: FAD-AMP lyase (cyclizing) || Phosphorus-oxygen lyases |
| DhaL-like | 0.02264 | INHERITED FROM: FAD-AMP lyase (cyclizing) || Phosphorus-oxygen lyases |
| SCP-like | 0.02327 | INHERITED FROM: hydratase || Enoyl-CoA hydratase 2 || Hydro-lyases |
| NHL repeat | 0.02481 | INHERITED FROM: Peptidylamidoglycolate lyase || Carbon-nitrogen lyases || Lyases acting on amides, amidines, etc |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.08007 | INHERITED FROM: Carbon-carbon lyases || Dihydroneopterin aldolase || Aldehyde-lyases |
| Mss4-like | 0.1058 | INHERITED FROM: Carbon-sulfur lyases || S-(hydroxymethyl)glutathione synthase |
| Galactose mutarotase-like | 0.1081 | INHERITED FROM: Hyaluronate lyase || Rhamnogalacturonan endolyase || Acting on polysaccharides || Carbon-oxygen lyases || Chondroitin-sulfate-ABC exolyase |
| Ran binding protein zinc finger-like | 0.4084 | INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| DNase I-like | 0.4293 | INHERITED FROM: Other carbon-oxygen lyases || Carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| Ribokinase-like | 0.4612 | INHERITED FROM: ADP-dependent NAD(P)H-hydrate dehydratase || ATP-dependent NAD(P)H-hydrate dehydratase || Carbon-oxygen lyases || Hydro-lyases |
| Radical SAM enzymes | 0.5098 | INHERITED FROM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase || tRNA 4-demethylwyosine synthase (AdoMet-dependent) || GTP 3',8-cyclase || Carbon-carbon lyases || Other carbon-nitrogen lyases || Carbon-nitrogen lyases || 7-carboxy-7-deazaguanine synthase || Ammonia-lyases || Other carbon-carbon lyases |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.6269 | INHERITED FROM: Enoyl-CoA hydratase || Carbon-oxygen lyases || Hydro-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.6623 | INHERITED FROM: Aminodeoxychorismate lyase || Oxo-acid-lyases |
| CBS-domain pair | 0.6718 | INHERITED FROM: Cystathionine beta-synthase |
| DHS-like NAD/FAD-binding domain | 0.6894 | INHERITED FROM: Carbon-carbon lyases || Branched-chain-2-oxoacid decarboxylase || Carboxy-lyases || Phenylpyruvate decarboxylase || Indolepyruvate decarboxylase || Pyruvate decarboxylase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.8292 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| ACT-like | 0.894 | INHERITED FROM: Prephenate dehydratase || Threonine ammonia-lyase || Carbon-nitrogen lyases || Arogenate dehydratase || Ammonia-lyases |
| RNI-like | 0.9011 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| ACP-like | 0.9595 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| NTF2-like | 0.9595 | INHERITED FROM: Scytalone dehydratase |
| Bet v1-like | 0.9906 | INHERITED FROM: (S)-norcoclaurine synthase |
| EPT/RTPC-like | 1 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Acting on phosphates |
| PP2C-like | 1 | INHERITED FROM: Adenylate cyclase |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| "Winged helix" DNA-binding domain | 1 | INHERITED FROM: Alkylmercury lyase |
| Thioredoxin-like | 1 | INHERITED FROM: Carbon-halide lyases |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 1 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| EF-hand | 1 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Ferritin-like | 1 | INHERITED FROM: Aldehyde oxygenase (deformylating) |
| Lipoxigenase | 1 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| L domain-like | 1 | INHERITED FROM: Adenylate cyclase || Phosphorus-oxygen lyases |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| Triosephosphate isomerase (TIM) | 1 | INHERITED FROM: Acting on phosphates || Methylglyoxal synthase |
| UBA-like | 1 | INHERITED FROM: N-acetylmuramic acid 6-phosphate etherase |
| Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydroneopterin aldolase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Other carbon-oxygen lyases || Tuliposide A-converting enzyme || 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase |
| Cytochrome P450 | 1 | INHERITED FROM: Hydroperoxide dehydratase || Hydroperoxy icosatetraenoate dehydratase || Hydro-lyases || Colneleate synthase |
| CheY-like | 1 | INHERITED FROM: Ornithine decarboxylase |
| Flavoproteins | 1 | INHERITED FROM: tRNA 4-demethylwyosine synthase (AdoMet-dependent) || Oxo-acid-lyases |
| Acylphosphatase/BLUF domain-like | 1 | INHERITED FROM: Adenylate cyclase |
| Carbon-nitrogen hydrolase | 1 | INHERITED FROM: 3-cyanoalanine hydratase || Cyanide hydratase |
| HAD-like | 1 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase || Imidazoleglycerol-phosphate dehydratase |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| SMAD/FHA domain | 1 | INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase || Oleate hydratase |
| PRTase-like | 1 | INHERITED FROM: Orotidine-5'-phosphate decarboxylase |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase || Phosphorus-oxygen lyases |
| PLC-like phosphodiesterases | 1 | INHERITED FROM: Phosphatidylinositol diacylglycerol-lyase || Phosphorus-oxygen lyases |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Malolactic enzyme || Acting on phosphates |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase || Aldehyde-lyases |
| PLP-dependent transferases | 1 | INHERITED FROM: Cysteine-S-conjugate beta-lyase || Threonine-phosphate decarboxylase || Histidine decarboxylase || Aromatic-L-amino-acid decarboxylase || Carbon-carbon lyases || Lysine decarboxylase || 1-aminocyclopropane-1-carboxylate synthase || Cystathionine gamma-lyase || Tyrosine phenol-lyase || Diaminobutyrate decarboxylase || Selenocysteine lyase || Sulfinoalanine decarboxylase || Tryptophanase || Carbon-sulfur lyases || Low-specificity L-threonine aldolase || Aspartate 1-decarboxylase || L-tryptophan decarboxylase || Sphinganine-1-phosphate aldolase || Ethanolamine-phosphate phospho-lyase || Tyrosine decarboxylase || Other carbon-carbon lyases || 3,4-dihydroxyphenylacetaldehyde synthase || Glutamate decarboxylase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Diaminopimelate epimerase-like | 1 | INHERITED FROM: Trans-L-3-hydroxyproline dehydratase |
| Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| TPR-like | 1 | INHERITED FROM: Adenylate cyclase |
| GST C-terminal domain-like | 1 | INHERITED FROM: Carbon-halide lyases |
| PFL-like glycyl radical enzymes | 1 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Carbon-carbon lyases || Dihydroneopterin aldolase || Aldehyde-lyases || 6-carboxytetrahydropterin synthase || 6-pyruvoyltetrahydropterin synthase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: 3-dehydroquinate synthase |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: Sulfopyruvate decarboxylase || Carbon-carbon lyases || Branched-chain-2-oxoacid decarboxylase || 2-oxoglutarate decarboxylase || Carboxy-lyases || Phenylpyruvate decarboxylase || Indolepyruvate decarboxylase || Pyruvate decarboxylase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Citrate (pro-3S)-lyase |
| FabD/lysophospholipase-like | 1 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-dehydroquinate synthase || Other lyases || dTDP-glucose 4,6-dehydratase || hydratase || Enoyl-CoA hydratase || Enoyl-CoA hydratase 2 || 3-dehydroquinate dehydratase || Ornithine cyclodeaminase || GDP-mannose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || Malolactic enzyme || Sirohydrochlorin ferrochelatase || Aldehyde oxygenase (deformylating) || UDP-glucuronate decarboxylase |
| Galactose-binding domain-like | 1 | INHERITED FROM: Rhamnogalacturonan endolyase || Acting on polysaccharides || Chondroitin-sulfate-ABC exolyase |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: Guanylate cyclase || Phosphorus-oxygen lyases |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PCD-like | 0 | Direct |
| Urocanase | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Bacterial muramidases | 0 | Direct |
| Ribonuclease Rh-like | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| RNase A-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
| Lysozyme-like | 0 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
| RraA-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Chondroitin AC/alginate lyase | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| Indigoidine synthase A-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| MK0786-like | 0 | Direct |
| UbiD C-terminal domain-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| NosL/MerB-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Chelatase | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| Chlorophyll a-b binding protein | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| Ribosomal protein S3 C-terminal domain | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| FAH | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| IpsF-like | 0 | Direct |
| S13-like H2TH domain | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| ADC synthase | 0 | Direct |
| Aldolase | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| HemD-like | 0 | Direct |
| RibA-like | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Adenylylcyclase toxin (the edema factor) | 0 | Direct |
| Pectin lyase-like | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| IlvD/EDD N-terminal domain-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| Gamma-glutamyl cyclotransferase-like | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| Molybdenum cofactor biosynthesis protein C, MoaC | 0 | Direct |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | Direct |
| ADC-like | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| Periplasmic binding protein-like I | 0 | Direct |
| AttH-like | 0 | Direct |
| Prokaryotic type KH domain (KH-domain type II) | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0.00000000000001193 | Direct |
| Xylose isomerase-like | 0.000000000000217 | Direct |
| UraD-Like | 0.000000000005654 | Direct |
| AF0104/ALDC/Ptd012-like | 0.00000000006387 | Direct |
| CoaB-like | 0.0000000001962 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000001051 | Direct |
| Nitrile hydratase alpha chain | 0.000000003987 | Direct |
| ClpP/crotonase | 0.000000004047 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0000002445 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.000000314 | Direct |
| Methylglyoxal synthase-like | 0.0000009252 | Direct |
| SIS domain | 0.000001238 | Direct |
| Electron transport accessory proteins | 0.000001701 | Direct |
| YjeF N-terminal domain-like | 0.000008302 | Direct |
| TATA-box binding protein-like | 0.000008711 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.000008711 | Direct |
| Starch-binding domain-like | 0.00002781 | Direct |
| Chorismate mutase II | 0.00003265 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.00006968 | Direct |
| Serine metabolism enzymes domain | 0.0001414 | Direct |
| PHM/PNGase F | 0.0001721 | Direct |
| Periplasmic binding protein-like II | 0.0006624 | Direct |
| RmlC-like cupins | 0.002675 | Inherited |
| MAPEG domain-like | 0.005452 | Inherited |
| Barwin-like endoglucanases | 0.005644 | Inherited |
| Tautomerase/MIF | 0.006449 | Inherited |
| HSP20-like chaperones | 0.007354 | Inherited |
| Calcium-dependent phosphotriesterase | 0.0207 | Inherited |
| DAK1/DegV-like | 0.02264 | Inherited |
| DhaL-like | 0.02264 | Inherited |
| SCP-like | 0.02327 | Inherited |
| NHL repeat | 0.02481 | Inherited |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.08007 | Inherited |
| Mss4-like | 0.1058 | Inherited |
| Galactose mutarotase-like | 0.1081 | Inherited |
| Ran binding protein zinc finger-like | 0.4084 | Inherited |
| DNase I-like | 0.4293 | Inherited |
| Ribokinase-like | 0.4612 | Inherited |
| Radical SAM enzymes | 0.5098 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.6269 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.6623 | Inherited |
| CBS-domain pair | 0.6718 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.6894 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.8292 | Inherited |
| ACT-like | 0.894 | Inherited |
| RNI-like | 0.9011 | Inherited |
| ACP-like | 0.9595 | Inherited |
| NTF2-like | 0.9595 | Inherited |
| Bet v1-like | 0.9906 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| PP2C-like | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| "Winged helix" DNA-binding domain | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Ferritin-like | 1 | Inherited |
| Lipoxigenase | 1 | Inherited |
| L domain-like | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| Triosephosphate isomerase (TIM) | 1 | Inherited |
| UBA-like | 1 | Inherited |
| Dihydropteroate synthetase-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| CheY-like | 1 | Inherited |
| Flavoproteins | 1 | Inherited |
| Acylphosphatase/BLUF domain-like | 1 | Inherited |
| Carbon-nitrogen hydrolase | 1 | Inherited |
| HAD-like | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| SMAD/FHA domain | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| PRTase-like | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| PLC-like phosphodiesterases | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | Inherited |
| Diaminopimelate epimerase-like | 1 | Inherited |
| Rudiment single hybrid motif | 1 | Inherited |
| TPR-like | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| PFL-like glycyl radical enzymes | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| FabD/lysophospholipase-like | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Galactose-binding domain-like | 1 | Inherited |
| Protein kinase-like (PK-like) | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| RraA-like | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Ferrochelatase | 0 | DIRECT |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, middle domain | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| D-glucarate dehydratase-like | 0 | DIRECT |
| tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
| Serine dehydratase beta chain-like | 0 | DIRECT |
| Mevalonate 5-diphosphate decarboxylase | 0 | DIRECT |
| Terpenoid cyclase N-terminal domain | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| UxuA-like | 0 | DIRECT |
| Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
| Glyoxalase I (lactoylglutathione lyase) | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| IlvD/EDD C-terminal domain-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | DIRECT |
| MerB N-terminal domain-like | 0 | DIRECT |
| BLUF domain | 0 | DIRECT |
| Scytalone dehydratase | 0 | DIRECT |
| Bacterial muramidase, catalytic domain | 0 | DIRECT |
| CbiX-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| H-NOX domain | 0 | DIRECT |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| Terpenoid cyclase C-terminal domain | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | DIRECT |
| HAL/PAL-like | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| FabZ-like | 0 | DIRECT |
| C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Class II FBP aldolase | 0 | DIRECT |
| lvD/EDD N-terminal domain-like | 0 | DIRECT |
| Ornithine decarboxylase N-terminal "wing" domain | 0 | DIRECT |
| Cyanase N-terminal domain | 0 | DIRECT |
| Hyaluronate lyase-like, central domain | 0 | DIRECT |
| HMGL-like | 0 | DIRECT |
| Ornithine decarboxylase major domain | 0 | DIRECT |
| Tryptophan biosynthesis enzymes | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| Beta-eliminating lyases | 0 | DIRECT |
| Ribonuclease Rh-like | 0 | DIRECT |
| Adenylylcyclase toxin (the edema factor) | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| Nitrile hydratase beta chain | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| Aristolochene/pentalenene synthase | 0 | DIRECT |
| Dimeric chorismate mutase | 0 | DIRECT |
| YjeF C-terminal domain-like | 0 | DIRECT |
| PMT1231-like | 0 | DIRECT |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Hypothetical protein VC1974 | 0 | DIRECT |
| Dehydroquinate synthase, DHQS | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | DIRECT |
| MaoC-like | 0 | DIRECT |
| AttH-like | 0 | DIRECT |
| mono-SIS domain | 0 | DIRECT |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | DIRECT |
| Cobalt chelatase CbiK | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| MK0786-like | 0 | DIRECT |
| Hyaluronate lyase-like catalytic, N-terminal domain | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Alginate lyase A1-III | 0 | DIRECT |
| Autoinducer-2 production protein LuxS | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| MLTA-like | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | DIRECT |
| Gamma-glutamyl cyclotransferase-like | 0 | DIRECT |
| Histidine biosynthesis enzymes | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| Formaldehyde-activating enzyme, FAE | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| Trichodiene synthase | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| 6-pyruvoyl tetrahydropterin synthase | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Ribonuclease A-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Chorismate lyase | 0 | DIRECT |
| DmpG/LeuA communication domain-like | 0 | DIRECT |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | DIRECT |
| Methylglyoxal synthase, MgsA | 0 | DIRECT |
| Arginine decarboxylase | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| Prokaryotic type KH domain (KH-domain type II) | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| Siroheme synthase N-terminal domain-like | 0 | DIRECT |
| Uroporphyrinogen decarboxylase, UROD | 0 | DIRECT |
| Pectate lyase-like | 0 | DIRECT |
| IpsF-like | 0 | DIRECT |
| HpcH/HpaI aldolase | 0 | DIRECT |
| Alpha-acetolactate decarboxylase-like | 0 | DIRECT |
| Bacterial PLC | 0 | DIRECT |
| PdxS-like | 0 | DIRECT |
| UbiD middle domain-like | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Endonuclease III | 0 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | DIRECT |
| MerB-like | 0 | DIRECT |
| Enolase | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| Ureidoglycolate hydrolase AllA | 0 | DIRECT |
| UbiD C-terminal domain-like | 0 | DIRECT |
| Chlorophyll a-b binding protein | 0 | DIRECT |
| Molybdenum cofactor biosynthesis protein C, MoaC | 0 | DIRECT |
| Indigoidine synthase A-like | 0 | DIRECT |
| FAH | 0 | DIRECT |
| L-arabinose binding protein-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| MoCo biosynthesis proteins | 0 | DIRECT |
| Decarboxylase | 0 | DIRECT |
| Allosteric threonine deaminase C-terminal domain | 0 | DIRECT |
| Histidine decarboxylase | 0 | DIRECT |
| AgoG-like | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Middle domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Pectate transeliminase | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| Bacterial S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Pectin lyase | 0 | DIRECT |
| Chondroitin ABC lyase I, N-terminal domain | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| Glutathione-dependent formaldehyde-activating enzyme, Gfa | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| RuBisCo, large subunit, C-terminal domain | 0 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0 | DIRECT |
| Phosphoenolpyruvate carboxylase | 0 | DIRECT |
| DHN aldolase/epimerase | 0 | DIRECT |
| Pyruvate oxidase and decarboxylase, middle domain | 0.0000000000002831 | DIRECT |
| UraD-like | 0.000000000008522 | DIRECT |
| CoaB-like | 0.0000000003438 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000005198 | DIRECT |
| DNase I-like | 0.000000008447 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.00000002466 | DIRECT |
| PP1699/LP2961-like | 0.0000000589 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0000002714 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000003726 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0.0000003985 | DIRECT |
| Proline racemase | 0.0000005064 | DIRECT |
| Cystathionine synthase-like | 0.000008414 | DIRECT |
| Co-chaperone p23-like | 0.00001035 | DIRECT |
| DNA repair glycosylase, N-terminal domain | 0.00001035 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.00001035 | DIRECT |
| DJ-1/PfpI | 0.0000179 | DIRECT |
| Acyl-carrier protein (ACP) | 0.00001928 | DIRECT |
| YjeF N-terminal domain-like | 0.00002162 | DIRECT |
| DNA repair glycosylase, 2 C-terminal domains | 0.00006305 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0.0001203 | DIRECT |
| Internalin LRR domain | 0.0002226 | DIRECT |
| MIF-related | 0.0003594 | DIRECT |
| Pyruvate oxidase and decarboxylase PP module | 0.0006436 | DIRECT |
| Shikimate kinase (AroK) | 0.001094 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Acting on phosphates || Carbon-oxygen lyases || Hydro-lyases |
| PFL-like | 0.002238 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| Germin/Seed storage 7S protein | 0.003762 | INHERITED FROM: Oxalate decarboxylase || Carbon-carbon lyases || Carboxy-lyases |
| MAPEG domain | 0.004664 | INHERITED FROM: Leukotriene-C(4) synthase || Carbon-sulfur lyases |
| Ornithine cyclodeaminase-like | 0.005015 | INHERITED FROM: Carbon-nitrogen lyases || Ornithine cyclodeaminase || Ammonia-lyases |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.005599 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase || Carbon-oxygen lyases || Hydro-lyases |
| DhaL-like | 0.01991 | INHERITED FROM: FAD-AMP lyase (cyclizing) || Phosphorus-oxygen lyases |
| NHL repeat | 0.02346 | INHERITED FROM: Peptidylamidoglycolate lyase || Carbon-nitrogen lyases || Lyases acting on amides, amidines, etc |
| Sterol carrier protein, SCP | 0.02464 | INHERITED FROM: hydratase || Enoyl-CoA hydratase 2 || Hydro-lyases |
| DAK1 | 0.02563 | INHERITED FROM: FAD-AMP lyase (cyclizing) || Phosphorus-oxygen lyases |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.09069 | INHERITED FROM: Carbon-carbon lyases || Dihydroneopterin aldolase || Aldehyde-lyases |
| FabD-like | 0.1069 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase || Carbon-oxygen lyases || Hydro-lyases |
| Carboxylesterase | 0.1105 | INHERITED FROM: Other carbon-oxygen lyases || Tuliposide A-converting enzyme || Carbon-oxygen lyases |
| Shikimate dehydrogenase-like | 0.1155 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Acting on phosphates || Carbon-oxygen lyases || Hydro-lyases |
| Animal lipoxigenases | 0.1347 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| Pyruvate oxidase and decarboxylase Pyr module | 0.1637 | INHERITED FROM: Carbon-carbon lyases || Branched-chain-2-oxoacid decarboxylase || Carboxy-lyases || Phenylpyruvate decarboxylase || Indolepyruvate decarboxylase || Pyruvate decarboxylase |
| Phosphate binding protein-like | 0.2811 | INHERITED FROM: Peptidoglycan lytic exotransglycosylase || Prephenate dehydratase || Chorismate dehydratase || Acting on polysaccharides || Arogenate dehydratase || Carbon-oxygen lyases |
| Ran binding protein zinc finger-like | 0.4226 | INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.4267 | INHERITED FROM: Enoyl-CoA hydratase || Carbon-oxygen lyases || Hydro-lyases |
| Terpene synthases | 0.5552 | INHERITED FROM: Squalene--hopanol cyclase |
| CoA transferase alpha subunit-like | 0.5967 | INHERITED FROM: Oxo-acid-lyases || Citrate (pro-3S)-lyase |
| CBS-domain pair | 0.6592 | INHERITED FROM: Cystathionine beta-synthase |
| Cytidylytransferase | 0.7074 | INHERITED FROM: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase || Phosphorus-oxygen lyases |
| Dihydropteroate synthetase | 0.7654 | INHERITED FROM: Dihydroneopterin aldolase || Aldehyde-lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.7933 | INHERITED FROM: Aminodeoxychorismate lyase || Oxo-acid-lyases |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.8321 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.9429 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| CAT-like | 0.9786 | INHERITED FROM: 2-oxoglutarate decarboxylase || Carboxy-lyases |
| Lipoxigenase N-terminal domain | 0.9829 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| Malic enzyme N-domain | 1 | INHERITED FROM: Malolactic enzyme |
| Branched-chain alpha-keto acid dehydrogenase PP module | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Glutathione S-transferase (GST), C-terminal domain | 1 | INHERITED FROM: Carbon-halide lyases |
| Protein kinases, catalytic subunit | 1 | INHERITED FROM: Guanylate cyclase || Phosphorus-oxygen lyases |
| Thiolase-related | 1 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| FHA domain | 1 | INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| GHMP Kinase, N-terminal domain | 1 | INHERITED FROM: Bisphosphomevalonate decarboxylase || Diphosphomevalonate decarboxylase |
| AAT-like | 1 | INHERITED FROM: Cysteine-S-conjugate beta-lyase || Threonine-phosphate decarboxylase || Aldehyde-lyases || Carbon-sulfur lyases || Low-specificity L-threonine aldolase || Alliin lyase |
| Triosephosphate isomerase (TIM) | 1 | INHERITED FROM: Acting on phosphates || Methylglyoxal synthase |
| BC C-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: dTDP-glucose 4,6-dehydratase || hydratase || Enoyl-CoA hydratase 2 || GDP-mannose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || Hydro-lyases || UDP-glucuronate decarboxylase |
| Enolase-phosphatase E1 | 1 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Malolactic enzyme |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | INHERITED FROM: Tartrate decarboxylase |
| FAD-linked reductases, N-terminal domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase || Aldehyde-lyases |
| Enolpyruvate transferase, EPT | 1 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Acting on phosphates |
| Phosphoribosyltransferases (PRTases) | 1 | INHERITED FROM: Orotidine-5'-phosphate decarboxylase |
| GABA-aminotransferase-like | 1 | INHERITED FROM: 1-aminocyclopropane-1-carboxylate synthase || Carbon-sulfur lyases || Ethanolamine-phosphate phospho-lyase |
| SAICAR synthase | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| BC N-terminal domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| PP2C-like | 1 | INHERITED FROM: Adenylate cyclase |
| Cytochrome p450 reductase N-terminal domain-like | 1 | INHERITED FROM: tRNA 4-demethylwyosine synthase (AdoMet-dependent) || Oxo-acid-lyases |
| GMC oxidoreductases | 1 | INHERITED FROM: (R)-mandelonitrile lyase || Aldehyde-lyases |
| Biotin synthase | 1 | INHERITED FROM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase |
| BC ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Cytochrome P450 | 1 | INHERITED FROM: Hydroperoxide dehydratase || Hydroperoxy icosatetraenoate dehydratase || Hydro-lyases || Colneleate synthase |
| Glutathione S-transferase (GST), N-terminal domain | 1 | INHERITED FROM: Carbon-halide lyases |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| RraA-like | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Ferrochelatase | 0 | Direct |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | Direct |
| Rhamnogalacturonase B, RhgB, middle domain | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| D-glucarate dehydratase-like | 0 | Direct |
| tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
| Serine dehydratase beta chain-like | 0 | Direct |
| Mevalonate 5-diphosphate decarboxylase | 0 | Direct |
| Terpenoid cyclase N-terminal domain | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| UxuA-like | 0 | Direct |
| Ribosomal protein S3 C-terminal domain | 0 | Direct |
| Glyoxalase I (lactoylglutathione lyase) | 0 | Direct |
| Bacterial muramidases | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| IlvD/EDD C-terminal domain-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | Direct |
| MerB N-terminal domain-like | 0 | Direct |
| BLUF domain | 0 | Direct |
| Scytalone dehydratase | 0 | Direct |
| Bacterial muramidase, catalytic domain | 0 | Direct |
| CbiX-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| H-NOX domain | 0 | Direct |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| Terpenoid cyclase C-terminal domain | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | Direct |
| HAL/PAL-like | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| FabZ-like | 0 | Direct |
| C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | Direct |
| Class II FBP aldolase | 0 | Direct |
| lvD/EDD N-terminal domain-like | 0 | Direct |
| Ornithine decarboxylase N-terminal "wing" domain | 0 | Direct |
| Cyanase N-terminal domain | 0 | Direct |
| Hyaluronate lyase-like, central domain | 0 | Direct |
| HMGL-like | 0 | Direct |
| Ornithine decarboxylase major domain | 0 | Direct |
| Tryptophan biosynthesis enzymes | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| Beta-eliminating lyases | 0 | Direct |
| Ribonuclease Rh-like | 0 | Direct |
| Adenylylcyclase toxin (the edema factor) | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| Nitrile hydratase beta chain | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| Class I aldolase | 0 | Direct |
| Aristolochene/pentalenene synthase | 0 | Direct |
| Dimeric chorismate mutase | 0 | Direct |
| YjeF C-terminal domain-like | 0 | Direct |
| PMT1231-like | 0 | Direct |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Hypothetical protein VC1974 | 0 | Direct |
| Dehydroquinate synthase, DHQS | 0 | Direct |
| LeuD-like | 0 | Direct |
| Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | Direct |
| MaoC-like | 0 | Direct |
| AttH-like | 0 | Direct |
| mono-SIS domain | 0 | Direct |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | Direct |
| Cobalt chelatase CbiK | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| MK0786-like | 0 | Direct |
| Hyaluronate lyase-like catalytic, N-terminal domain | 0 | Direct |
| HemD-like | 0 | Direct |
| Alginate lyase A1-III | 0 | Direct |
| Autoinducer-2 production protein LuxS | 0 | Direct |
| ADC synthase | 0 | Direct |
| MLTA-like | 0 | Direct |
| Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | Direct |
| Gamma-glutamyl cyclotransferase-like | 0 | Direct |
| Histidine biosynthesis enzymes | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| Formaldehyde-activating enzyme, FAE | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| RibA-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| Trichodiene synthase | 0 | Direct |
| Crotonase-like | 0 | Direct |
| 6-pyruvoyl tetrahydropterin synthase | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Ribonuclease A-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Chorismate lyase | 0 | Direct |
| DmpG/LeuA communication domain-like | 0 | Direct |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | Direct |
| Methylglyoxal synthase, MgsA | 0 | Direct |
| Arginine decarboxylase | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| Prokaryotic type KH domain (KH-domain type II) | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| Siroheme synthase N-terminal domain-like | 0 | Direct |
| Uroporphyrinogen decarboxylase, UROD | 0 | Direct |
| Pectate lyase-like | 0 | Direct |
| IpsF-like | 0 | Direct |
| HpcH/HpaI aldolase | 0 | Direct |
| Alpha-acetolactate decarboxylase-like | 0 | Direct |
| Bacterial PLC | 0 | Direct |
| PdxS-like | 0 | Direct |
| UbiD middle domain-like | 0 | Direct |
| PCD-like | 0 | Direct |
| Endonuclease III | 0 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | Direct |
| MerB-like | 0 | Direct |
| Enolase | 0 | Direct |
| Urocanase | 0 | Direct |
| Ureidoglycolate hydrolase AllA | 0 | Direct |
| UbiD C-terminal domain-like | 0 | Direct |
| Chlorophyll a-b binding protein | 0 | Direct |
| Molybdenum cofactor biosynthesis protein C, MoaC | 0 | Direct |
| Indigoidine synthase A-like | 0 | Direct |
| FAH | 0 | Direct |
| L-arabinose binding protein-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| MoCo biosynthesis proteins | 0 | Direct |
| Decarboxylase | 0 | Direct |
| Allosteric threonine deaminase C-terminal domain | 0 | Direct |
| Histidine decarboxylase | 0 | Direct |
| AgoG-like | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| Middle domain of MutM-like DNA repair proteins | 0 | Direct |
| Pectate transeliminase | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| Bacterial S-adenosylmethionine decarboxylase | 0 | Direct |
| Pectin lyase | 0 | Direct |
| Chondroitin ABC lyase I, N-terminal domain | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| Glutathione-dependent formaldehyde-activating enzyme, Gfa | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| RuBisCo, large subunit, C-terminal domain | 0 | Direct |
| Imidazole glycerol phosphate dehydratase | 0 | Direct |
| Phosphoenolpyruvate carboxylase | 0 | Direct |
| DHN aldolase/epimerase | 0 | Direct |
| Pyruvate oxidase and decarboxylase, middle domain | 0.0000000000002831 | Direct |
| UraD-like | 0.000000000008522 | Direct |
| CoaB-like | 0.0000000003438 | Direct |
| Nitrile hydratase alpha chain | 0.000000005198 | Direct |
| DNase I-like | 0.000000008447 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.00000002466 | Direct |
| PP1699/LP2961-like | 0.0000000589 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0000002714 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.0000003726 | Direct |
| Phenylalanine metabolism regulatory domain | 0.0000003985 | Direct |
| Proline racemase | 0.0000005064 | Direct |
| Cystathionine synthase-like | 0.000008414 | Direct |
| Co-chaperone p23-like | 0.00001035 | Direct |
| DNA repair glycosylase, N-terminal domain | 0.00001035 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.00001035 | Direct |
| DJ-1/PfpI | 0.0000179 | Direct |
| Acyl-carrier protein (ACP) | 0.00001928 | Direct |
| YjeF N-terminal domain-like | 0.00002162 | Direct |
| DNA repair glycosylase, 2 C-terminal domains | 0.00006305 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0.0001203 | Direct |
| Internalin LRR domain | 0.0002226 | Direct |
| MIF-related | 0.0003594 | Direct |
| Pyruvate oxidase and decarboxylase PP module | 0.0006436 | Direct |
| Shikimate kinase (AroK) | 0.001094 | Inherited |
| PFL-like | 0.002238 | Inherited |
| Germin/Seed storage 7S protein | 0.003762 | Inherited |
| MAPEG domain | 0.004664 | Inherited |
| Ornithine cyclodeaminase-like | 0.005015 | Inherited |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.005599 | Inherited |
| DhaL-like | 0.01991 | Inherited |
| NHL repeat | 0.02346 | Inherited |
| Sterol carrier protein, SCP | 0.02464 | Inherited |
| DAK1 | 0.02563 | Inherited |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.09069 | Inherited |
| FabD-like | 0.1069 | Inherited |
| Carboxylesterase | 0.1105 | Inherited |
| Shikimate dehydrogenase-like | 0.1155 | Inherited |
| Animal lipoxigenases | 0.1347 | Inherited |
| Pyruvate oxidase and decarboxylase Pyr module | 0.1637 | Inherited |
| Phosphate binding protein-like | 0.2811 | Inherited |
| Ran binding protein zinc finger-like | 0.4226 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.4267 | Inherited |
| Terpene synthases | 0.5552 | Inherited |
| CoA transferase alpha subunit-like | 0.5967 | Inherited |
| CBS-domain pair | 0.6592 | Inherited |
| Cytidylytransferase | 0.7074 | Inherited |
| Dihydropteroate synthetase | 0.7654 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.7933 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.8321 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.9429 | Inherited |
| CAT-like | 0.9786 | Inherited |
| Lipoxigenase N-terminal domain | 0.9829 | Inherited |
| Malic enzyme N-domain | 1 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase PP module | 1 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 1 | Inherited |
| Protein kinases, catalytic subunit | 1 | Inherited |
| Thiolase-related | 1 | Inherited |
| FHA domain | 1 | Inherited |
| GHMP Kinase, N-terminal domain | 1 | Inherited |
| AAT-like | 1 | Inherited |
| Triosephosphate isomerase (TIM) | 1 | Inherited |
| BC C-terminal domain-like | 1 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| Enolase-phosphatase E1 | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | Inherited |
| FAD-linked reductases, N-terminal domain | 1 | Inherited |
| Enolpyruvate transferase, EPT | 1 | Inherited |
| Phosphoribosyltransferases (PRTases) | 1 | Inherited |
| GABA-aminotransferase-like | 1 | Inherited |
| SAICAR synthase | 1 | Inherited |
| BC N-terminal domain-like | 1 | Inherited |
| PP2C-like | 1 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 1 | Inherited |
| GMC oxidoreductases | 1 | Inherited |
| Biotin synthase | 1 | Inherited |
| BC ATP-binding domain-like | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Lysozyme-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| Chondroitin AC/alginate lyase | 0 | DIRECT |
| RraA-like | 0 | DIRECT |
| Tetrapyrrole methylase | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| AttH-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| Siroheme synthase middle domains-like | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Chelatase | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| 2-methylcitrate dehydratase PrpD | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| IlvD/EDD N-terminal domain-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| Molybdenum cofactor biosynthesis protein C, MoaC | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| UbiD C-terminal domain-like | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| NosL/MerB-like | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| IpsF-like | 0 | DIRECT |
| FAH | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Ribonuclease Rh-like | 0 | DIRECT |
| Chlorophyll a-b binding protein | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| MK0786-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| Gamma-glutamyl cyclotransferase-like | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Prokaryotic type KH domain (KH-domain type II) | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| RNase A-like | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Indigoidine synthase A-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Periplasmic binding protein-like I | 0 | DIRECT |
| Adenylylcyclase toxin (the edema factor) | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0.000000000000008377 | DIRECT |
| Xylose isomerase-like | 0.0000000000001543 | DIRECT |
| UraD-Like | 0.000000000004079 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0.00000000004672 | DIRECT |
| CoaB-like | 0.0000000001448 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.0000000007827 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000002991 | DIRECT |
| ClpP/crotonase | 0.000000003036 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0000001881 | DIRECT |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.000000242 | DIRECT |
| Methylglyoxal synthase-like | 0.0000007199 | DIRECT |
| SIS domain | 0.0000009655 | DIRECT |
| Electron transport accessory proteins | 0.000001331 | DIRECT |
| YjeF N-terminal domain-like | 0.000006552 | DIRECT |
| TATA-box binding protein-like | 0.000006876 | DIRECT |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.000006876 | DIRECT |
| Starch-binding domain-like | 0.00002217 | DIRECT |
| Chorismate mutase II | 0.00002606 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.00005591 | DIRECT |
| Serine metabolism enzymes domain | 0.0001143 | DIRECT |
| PHM/PNGase F | 0.0001395 | DIRECT |
| Periplasmic binding protein-like II | 0.0005436 | DIRECT |
| RmlC-like cupins | 0.002232 | INHERITED FROM: Carbon-nitrogen lyases || Lyases acting on amides, amidines, etc || Hydro-lyases || Ectoine synthase || Dimethylpropiothetin dethiomethylase || Oxalate decarboxylase || Peptidyl-glutamate 4-carboxylase || Ureidoglycolate lyase |
| MAPEG domain-like | 0.004579 | INHERITED FROM: Leukotriene-C(4) synthase || Carbon-sulfur lyases |
| Barwin-like endoglucanases | 0.004742 | INHERITED FROM: Acting on polysaccharides || Peptidoglycan lytic exotransglycosylase || Carbon-oxygen lyases |
| Tautomerase/MIF | 0.005428 | INHERITED FROM: D-dopachrome decarboxylase || Carboxy-lyases || Carbon-carbon lyases |
| HSP20-like chaperones | 0.006199 | INHERITED FROM: Hydro-lyases || Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase || Carbon-oxygen lyases |
| Integrin alpha N-terminal domain | 0.01313 | INHERITED FROM: Carbon-oxygen lyases |
| Calcium-dependent phosphotriesterase | 0.01769 | INHERITED FROM: Carbon-nitrogen lyases || Peptidylamidoglycolate lyase || Strictosidine synthase |
| DAK1/DegV-like | 0.01937 | INHERITED FROM: Phosphorus-oxygen lyases || FAD-AMP lyase (cyclizing) |
| DhaL-like | 0.01937 | INHERITED FROM: Phosphorus-oxygen lyases || FAD-AMP lyase (cyclizing) |
| SCP-like | 0.01992 | INHERITED FROM: Hydro-lyases || hydratase || Enoyl-CoA hydratase 2 |
| NHL repeat | 0.02125 | INHERITED FROM: Carbon-nitrogen lyases || Lyases acting on amides, amidines, etc || Peptidylamidoglycolate lyase |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.06962 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || Carbon-carbon lyases |
| Mss4-like | 0.09231 | INHERITED FROM: Carbon-sulfur lyases || S-(hydroxymethyl)glutathione synthase |
| Galactose mutarotase-like | 0.09439 | INHERITED FROM: Acting on polysaccharides || Rhamnogalacturonan endolyase || Carbon-oxygen lyases || Chondroitin-sulfate-ABC exolyase || Hyaluronate lyase |
| Ran binding protein zinc finger-like | 0.3703 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| DNase I-like | 0.3902 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Carbon-oxygen lyases || Other carbon-oxygen lyases |
| Ribokinase-like | 0.4201 | INHERITED FROM: ATP-dependent NAD(P)H-hydrate dehydratase || Hydro-lyases || ADP-dependent NAD(P)H-hydrate dehydratase || Carbon-oxygen lyases |
| Radical SAM enzymes | 0.4659 | INHERITED FROM: Carbon-nitrogen lyases || Ammonia-lyases || Other carbon-nitrogen lyases || Other carbon-carbon lyases || tRNA 4-demethylwyosine synthase (AdoMet-dependent) || 7-carboxy-7-deazaguanine synthase || 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase || Carbon-carbon lyases || GTP 3',8-cyclase |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.5754 | INHERITED FROM: Hydro-lyases || Enoyl-CoA hydratase || Carbon-oxygen lyases |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.6083 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| CBS-domain pair | 0.6172 | INHERITED FROM: Cystathionine beta-synthase |
| DHS-like NAD/FAD-binding domain | 0.6335 | INHERITED FROM: Pyruvate decarboxylase || Indolepyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases || Phenylpyruvate decarboxylase || Branched-chain-2-oxoacid decarboxylase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7638 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| ACT-like | 0.8251 | INHERITED FROM: Carbon-nitrogen lyases || Ammonia-lyases || Prephenate dehydratase || Arogenate dehydratase || Threonine ammonia-lyase |
| RNI-like | 0.8317 | INHERITED FROM: Phosphorus-oxygen lyases || Adenylate cyclase |
| ACP-like | 0.8877 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| NTF2-like | 0.8877 | INHERITED FROM: Scytalone dehydratase |
| Bet v1-like | 0.9175 | INHERITED FROM: (S)-norcoclaurine synthase |
| UBA-like | 0.9559 | INHERITED FROM: N-acetylmuramic acid 6-phosphate etherase |
| Lipoxigenase | 0.9568 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| SMAD/FHA domain | 0.9823 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| Galactose-binding domain-like | 1 | INHERITED FROM: Acting on polysaccharides || Rhamnogalacturonan endolyase || Chondroitin-sulfate-ABC exolyase |
| "Winged helix" DNA-binding domain | 1 | INHERITED FROM: Alkylmercury lyase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| PLP-dependent transferases | 1 | INHERITED FROM: Methionine gamma-lyase || Other carbon-carbon lyases || Diaminobutyrate decarboxylase || Tryptophanase || Selenocysteine lyase || Low-specificity L-threonine aldolase || 1-aminocyclopropane-1-carboxylate synthase || Carbon-sulfur lyases || Cystathionine gamma-lyase || Lysine decarboxylase || Ethanolamine-phosphate phospho-lyase || Histidine decarboxylase || Aromatic-L-amino-acid decarboxylase || Tyrosine decarboxylase || Carbon-carbon lyases || Aspartate 1-decarboxylase || Tyrosine phenol-lyase || 3,4-dihydroxyphenylacetaldehyde synthase || Sulfinoalanine decarboxylase || Cysteine-S-conjugate beta-lyase || Glutamate decarboxylase || Sphinganine-1-phosphate aldolase || L-tryptophan decarboxylase || Threonine-phosphate decarboxylase |
| Carbon-nitrogen hydrolase | 1 | INHERITED FROM: 3-cyanoalanine hydratase || Cyanide hydratase |
| Cytochrome P450 | 1 | INHERITED FROM: Colneleate synthase || Hydro-lyases || Hydroperoxy icosatetraenoate dehydratase || Hydroperoxide dehydratase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Citrate (pro-3S)-lyase |
| Thioredoxin-like | 1 | INHERITED FROM: Carbon-halide lyases |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| EF-hand | 1 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 1 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: Phosphorus-oxygen lyases || Guanylate cyclase |
| CheY-like | 1 | INHERITED FROM: Ornithine decarboxylase |
| FabD/lysophospholipase-like | 1 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| TPR-like | 1 | INHERITED FROM: Adenylate cyclase |
| GST C-terminal domain-like | 1 | INHERITED FROM: Carbon-halide lyases |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase || Tuliposide A-converting enzyme || Other carbon-oxygen lyases |
| Triosephosphate isomerase (TIM) | 1 | INHERITED FROM: Acting on phosphates || Methylglyoxal synthase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Other lyases || Ornithine cyclodeaminase || 3-dehydroquinate synthase || Sirohydrochlorin ferrochelatase || UDP-glucuronate decarboxylase || hydratase || dTDP-glucose 4,6-dehydratase || Enoyl-CoA hydratase || GDP-mannose 4,6-dehydratase || Aldehyde oxygenase (deformylating) || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || Malolactic enzyme || 3-dehydroquinate dehydratase || Enoyl-CoA hydratase 2 |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: 3-dehydroquinate synthase |
| PP2C-like | 1 | INHERITED FROM: Adenylate cyclase |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: Sulfopyruvate decarboxylase || Pyruvate decarboxylase || 2-oxoglutarate decarboxylase || Indolepyruvate decarboxylase || Carboxy-lyases || Carbon-carbon lyases || Phenylpyruvate decarboxylase || Branched-chain-2-oxoacid decarboxylase |
| EPT/RTPC-like | 1 | INHERITED FROM: 3-dehydroquinate synthase || Acting on phosphates || 3-dehydroquinate dehydratase |
| Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydroneopterin aldolase |
| PRTase-like | 1 | INHERITED FROM: Orotidine-5'-phosphate decarboxylase |
| Acylphosphatase/BLUF domain-like | 1 | INHERITED FROM: Adenylate cyclase |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: Phosphorus-oxygen lyases || 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| HAD-like | 1 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase || Hydro-lyases || Imidazoleglycerol-phosphate dehydratase |
| Ferritin-like | 1 | INHERITED FROM: Aldehyde oxygenase (deformylating) |
| L domain-like | 1 | INHERITED FROM: Phosphorus-oxygen lyases || Adenylate cyclase |
| Flavoproteins | 1 | INHERITED FROM: Oxo-acid-lyases || tRNA 4-demethylwyosine synthase (AdoMet-dependent) |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| PLC-like phosphodiesterases | 1 | INHERITED FROM: Phosphorus-oxygen lyases || Phosphatidylinositol diacylglycerol-lyase |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || 6-carboxytetrahydropterin synthase || Carbon-carbon lyases || 6-pyruvoyltetrahydropterin synthase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| Diaminopimelate epimerase-like | 1 | INHERITED FROM: Trans-L-3-hydroxyproline dehydratase |
| PFL-like glycyl radical enzymes | 1 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase || Oleate hydratase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate synthase || Acting on phosphates || Malolactic enzyme || 3-dehydroquinate dehydratase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Lysozyme-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| Dehydroquinate synthase-like | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| Chondroitin AC/alginate lyase | 0 | Direct |
| RraA-like | 0 | Direct |
| Tetrapyrrole methylase | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| AttH-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| Siroheme synthase middle domains-like | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| Aldolase | 0 | Direct |
| Ribosomal protein S3 C-terminal domain | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Chelatase | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| Pectin lyase-like | 0 | Direct |
| 2-methylcitrate dehydratase PrpD | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| IlvD/EDD N-terminal domain-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| PCD-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| Bacterial muramidases | 0 | Direct |
| Molybdenum cofactor biosynthesis protein C, MoaC | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| UbiD C-terminal domain-like | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| NosL/MerB-like | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| IpsF-like | 0 | Direct |
| FAH | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Ribonuclease Rh-like | 0 | Direct |
| Chlorophyll a-b binding protein | 0 | Direct |
| ADC-like | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| MK0786-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| Gamma-glutamyl cyclotransferase-like | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| HemD-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Prokaryotic type KH domain (KH-domain type II) | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| S13-like H2TH domain | 0 | Direct |
| tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| RibA-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| ADC synthase | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| RNase A-like | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| (2r)-phospho-3-sulfolactate synthase ComA | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Indigoidine synthase A-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| Periplasmic binding protein-like I | 0 | Direct |
| Adenylylcyclase toxin (the edema factor) | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Urocanase | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0.000000000000008377 | Direct |
| Xylose isomerase-like | 0.0000000000001543 | Direct |
| UraD-Like | 0.000000000004079 | Direct |
| AF0104/ALDC/Ptd012-like | 0.00000000004672 | Direct |
| CoaB-like | 0.0000000001448 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.0000000007827 | Direct |
| Nitrile hydratase alpha chain | 0.000000002991 | Direct |
| ClpP/crotonase | 0.000000003036 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0000001881 | Direct |
| Methenyltetrahydrofolate cyclohydrolase-like | 0.000000242 | Direct |
| Methylglyoxal synthase-like | 0.0000007199 | Direct |
| SIS domain | 0.0000009655 | Direct |
| Electron transport accessory proteins | 0.000001331 | Direct |
| YjeF N-terminal domain-like | 0.000006552 | Direct |
| TATA-box binding protein-like | 0.000006876 | Direct |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.000006876 | Direct |
| Starch-binding domain-like | 0.00002217 | Direct |
| Chorismate mutase II | 0.00002606 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.00005591 | Direct |
| Serine metabolism enzymes domain | 0.0001143 | Direct |
| PHM/PNGase F | 0.0001395 | Direct |
| Periplasmic binding protein-like II | 0.0005436 | Direct |
| RmlC-like cupins | 0.002232 | Inherited |
| MAPEG domain-like | 0.004579 | Inherited |
| Barwin-like endoglucanases | 0.004742 | Inherited |
| Tautomerase/MIF | 0.005428 | Inherited |
| HSP20-like chaperones | 0.006199 | Inherited |
| Integrin alpha N-terminal domain | 0.01313 | Inherited |
| Calcium-dependent phosphotriesterase | 0.01769 | Inherited |
| DAK1/DegV-like | 0.01937 | Inherited |
| DhaL-like | 0.01937 | Inherited |
| SCP-like | 0.01992 | Inherited |
| NHL repeat | 0.02125 | Inherited |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.06962 | Inherited |
| Mss4-like | 0.09231 | Inherited |
| Galactose mutarotase-like | 0.09439 | Inherited |
| Ran binding protein zinc finger-like | 0.3703 | Inherited |
| DNase I-like | 0.3902 | Inherited |
| Ribokinase-like | 0.4201 | Inherited |
| Radical SAM enzymes | 0.4659 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.5754 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.6083 | Inherited |
| CBS-domain pair | 0.6172 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.6335 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7638 | Inherited |
| ACT-like | 0.8251 | Inherited |
| RNI-like | 0.8317 | Inherited |
| ACP-like | 0.8877 | Inherited |
| NTF2-like | 0.8877 | Inherited |
| Bet v1-like | 0.9175 | Inherited |
| UBA-like | 0.9559 | Inherited |
| Lipoxigenase | 0.9568 | Inherited |
| SMAD/FHA domain | 0.9823 | Inherited |
| Galactose-binding domain-like | 1 | Inherited |
| "Winged helix" DNA-binding domain | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Carbon-nitrogen hydrolase | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| Rudiment single hybrid motif | 1 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | Inherited |
| Protein kinase-like (PK-like) | 1 | Inherited |
| CheY-like | 1 | Inherited |
| FabD/lysophospholipase-like | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| TPR-like | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| Triosephosphate isomerase (TIM) | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| PP2C-like | 1 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| Dihydropteroate synthetase-like | 1 | Inherited |
| PRTase-like | 1 | Inherited |
| Acylphosphatase/BLUF domain-like | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| HAD-like | 1 | Inherited |
| Ferritin-like | 1 | Inherited |
| L domain-like | 1 | Inherited |
| Flavoproteins | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
| PLC-like phosphodiesterases | 1 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| Diaminopimelate epimerase-like | 1 | Inherited |
| PFL-like glycyl radical enzymes | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53032,55267
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
53800,103511
53800 - Chelatase
103511 - Chlorophyll a-b binding protein | 0 | DIRECT |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | DIRECT |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
50475,143968
50475 - FMN-binding split barrel
143968 - UbiD C-terminal domain-like | 0 | DIRECT |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
55073,52540
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
53686,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like | 0 | DIRECT |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
74650,49863
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
54975,55073
54975 - Acylphosphatase/BLUF domain-like
55073 - Nucleotide cyclase | 0 | DIRECT |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | DIRECT |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | DIRECT |
49452,49785
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | DIRECT |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
53850,53955
53850 - Periplasmic binding protein-like II
53955 - Lysozyme-like | 0 | DIRECT |
48435,53955
48435 - Bacterial muramidases
53955 - Lysozyme-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | DIRECT |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | DIRECT |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
49785,48230
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase | 0 | DIRECT |
53448,69765
53448 - Nucleotide-diphospho-sugar transferases
69765 - IpsF-like | 0 | DIRECT |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
81624,46946
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain | 0 | DIRECT |
48557,55729
48557 - L-aspartase-like
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
56529,56529
56529 - FAH
56529 - FAH | 0 | DIRECT |
55073,55073
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase | 0 | DIRECT |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
51569,51366
51569 - Aldolase
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
48576,48576
48576 - Terpenoid synthases
48576 - Terpenoid synthases | 0 | DIRECT |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | DIRECT |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | DIRECT |
54211,54637
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
53822,56112
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48230,74650
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | DIRECT |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
53686,-9
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
-9 - PDB | 0 | DIRECT |
81606,55073
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | DIRECT |
64153,53613
64153 - YjeF N-terminal domain-like
53613 - Ribokinase-like | 0 | DIRECT |
55267,53032
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
54814,54821
54814 - Prokaryotic type KH domain (KH-domain type II)
54821 - Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
46946,57716
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
46785,160387
46785 - "Winged helix" DNA-binding domain
160387 - NosL/MerB-like | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | DIRECT |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
74650,49452
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like | 0 | DIRECT |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | DIRECT |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.0000003736 | DIRECT |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0.0000009418 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000001128 | DIRECT |
55945,48150
55945 - TATA-box binding protein-like
48150 - DNA-glycosylase | 0.000006876 | DIRECT |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.000006876 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0.00001532 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.0001395 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001739 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0002899 | DIRECT |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.0003778 | DIRECT |
52058,81606
52058 - L domain-like
81606 - PP2C-like | 0.0007782 | DIRECT |
82549,101473
82549 - DAK1/DegV-like
101473 - DhaL-like | 0.005952 | INHERITED FROM: Phosphorus-oxygen lyases || FAD-AMP lyase (cyclizing) |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.01269 | INHERITED FROM: Hydro-lyases || 3-hydroxyacyl-[acyl-carrier-protein] dehydratase || Enoyl-CoA hydratase 2 |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.01992 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase || Carbon-carbon lyases |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.1604 | INHERITED FROM: Dihydroneopterin aldolase || Carbon-carbon lyases |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.2137 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.2467 | INHERITED FROM: Oxo-acid-lyases || Citrate (pro-3S)-lyase |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.5573 | INHERITED FROM: Hydro-lyases || Enoyl-CoA hydratase || Carbon-oxygen lyases |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7638 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.865 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: 2-oxoglutarate decarboxylase |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-dehydroquinate synthase || Acting on phosphates || 3-dehydroquinate dehydratase |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | INHERITED FROM: Carbon-halide lyases |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | INHERITED FROM: Ammonia-lyases || Threonine ammonia-lyase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53032,55267
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
53800,103511
53800 - Chelatase
103511 - Chlorophyll a-b binding protein | 0 | Direct |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | Direct |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
50475,143968
50475 - FMN-binding split barrel
143968 - UbiD C-terminal domain-like | 0 | Direct |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
55073,52540
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
53686,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like | 0 | Direct |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | Direct |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
74650,49863
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | Direct |
54975,55073
54975 - Acylphosphatase/BLUF domain-like
55073 - Nucleotide cyclase | 0 | Direct |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | Direct |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | Direct |
49452,49785
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
51735,75615
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like | 0 | Direct |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
53850,53955
53850 - Periplasmic binding protein-like II
53955 - Lysozyme-like | 0 | Direct |
48435,53955
48435 - Bacterial muramidases
53955 - Lysozyme-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | Direct |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | Direct |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
49785,48230
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase | 0 | Direct |
53448,69765
53448 - Nucleotide-diphospho-sugar transferases
69765 - IpsF-like | 0 | Direct |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
81624,46946
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain | 0 | Direct |
48557,55729
48557 - L-aspartase-like
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
56529,56529
56529 - FAH
56529 - FAH | 0 | Direct |
55073,55073
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase | 0 | Direct |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
51569,51366
51569 - Aldolase
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
48576,48576
48576 - Terpenoid synthases
48576 - Terpenoid synthases | 0 | Direct |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | Direct |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | Direct |
54211,54637
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
53822,56112
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48230,74650
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | Direct |
75615,53790
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
53686,-9
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
-9 - PDB | 0 | Direct |
81606,55073
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | Direct |
64153,53613
64153 - YjeF N-terminal domain-like
53613 - Ribokinase-like | 0 | Direct |
55267,53032
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
54814,54821
54814 - Prokaryotic type KH domain (KH-domain type II)
54821 - Ribosomal protein S3 C-terminal domain | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
46946,57716
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
46785,160387
46785 - "Winged helix" DNA-binding domain
160387 - NosL/MerB-like | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | Direct |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
74650,49452
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like | 0 | Direct |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | Direct |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.0000003736 | Direct |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0.0000009418 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000001128 | Direct |
55945,48150
55945 - TATA-box binding protein-like
48150 - DNA-glycosylase | 0.000006876 | Direct |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.000006876 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0.00001532 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0.0001395 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001739 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0002899 | Direct |
54593,54593
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.0003778 | Direct |
52058,81606
52058 - L domain-like
81606 - PP2C-like | 0.0007782 | Direct |
82549,101473
82549 - DAK1/DegV-like
101473 - DhaL-like | 0.005952 | Inherited |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.01269 | Inherited |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.01992 | Inherited |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.1604 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.2137 | Inherited |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.2467 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.5573 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.7638 | Inherited |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.865 | Inherited |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | Inherited |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | Inherited |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 1 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 1 | Inherited |
55021,55021
55021 - ACT-like
55021 - ACT-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
53032,55267,53032
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
52058,81606,55073
52058 - L domain-like
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | DIRECT |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
53686,55021,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like
55021 - ACT-like | 0 | DIRECT |
49785,48230,74650
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | DIRECT |
81624,46946,57716
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
54211,54211,54637
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
55267,53032,55267
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48230,74650,49863
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
53822,56112,55073
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | DIRECT |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | DIRECT |
55073,55073,52540
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
55116,55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | DIRECT |
74650,49452,49785
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.0000008117 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000002175 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001739 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.008321 | INHERITED FROM: Hydro-lyases || 3-hydroxyacyl-[acyl-carrier-protein] dehydratase || Carbon-oxygen lyases |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.1604 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
53032,55267,53032
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
52058,81606,55073
52058 - L domain-like
81606 - PP2C-like
55073 - Nucleotide cyclase | 0 | Direct |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
53686,55021,55021
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
55021 - ACT-like
55021 - ACT-like | 0 | Direct |
49785,48230,74650
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | Direct |
81624,46946,57716
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
54211,54211,54637
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
55267,53032,55267
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48230,74650,49863
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
53822,56112,55073
53822 - Periplasmic binding protein-like I
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0 | Direct |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,75615,53790
51735 - NAD(P)-binding Rossmann-fold domains
75615 - Siroheme synthase middle domains-like
53790 - Tetrapyrrole methylase | 0 | Direct |
55073,55073,52540
55073 - Nucleotide cyclase
55073 - Nucleotide cyclase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
55116,55116,101262
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
101262 - Methenyltetrahydrofolate cyclohydrolase-like | 0 | Direct |
74650,49452,49785
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.0000008117 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000002175 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.0001739 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.008321 | Inherited |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.1604 | Inherited |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 1 | Inherited |
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