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Enzyme Commission (EC): Carbon-carbon lyases
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| RraA-like | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| MK0786-like | 0 | DIRECT |
| UbiD C-terminal domain-like | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| UraD-Like | 0 | DIRECT |
| PLP-dependent transferases | 0.0000000000001165 | DIRECT |
| DHS-like NAD/FAD-binding domain | 0.000000000008713 | DIRECT |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.0000000495 | DIRECT |
| Tautomerase/MIF | 0.000000627 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.000003475 | DIRECT |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0001075 | DIRECT |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.003546 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| Rudiment single hybrid motif | 0.06045 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| CoA-dependent acyltransferases | 0.1925 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| PFL-like glycyl radical enzymes | 0.2216 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| 2-methylcitrate dehydratase PrpD | 0.623 | INHERITED FROM: Carboxy-lyases || Cis-aconitate decarboxylase |
| FAH | 0.7078 | INHERITED FROM: Carboxy-lyases || Oxaloacetate decarboxylase || 2-oxo-3-hexenedioate decarboxylase || 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9191 | INHERITED FROM: Phosphatidylserine decarboxylase |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| EF-hand | 1 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Ferritin-like | 1 | INHERITED FROM: Aldehyde oxygenase (deformylating) |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| Dihydropteroate synthetase-like | 1 | INHERITED FROM: Dihydroneopterin aldolase |
| CheY-like | 1 | INHERITED FROM: Ornithine decarboxylase |
| Flavoproteins | 1 | INHERITED FROM: tRNA 4-demethylwyosine synthase (AdoMet-dependent) || Oxo-acid-lyases |
| ClpP/crotonase | 1 | INHERITED FROM: Ethylmalonyl-CoA decarboxylase || 1,4-dihydroxy-2-naphthoyl-CoA synthase || Oxo-acid-lyases |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| AraD/HMP-PK domain-like | 1 | INHERITED FROM: Rhamnulose-1-phosphate aldolase || 3-dehydro-4-phosphotetronate decarboxylase || Aldehyde-lyases || L-fuculose-phosphate aldolase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| PRTase-like | 1 | INHERITED FROM: Orotidine-5'-phosphate decarboxylase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Malolactic enzyme |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Indole-3-glycerol-phosphate synthase || Anthranilate synthase || Oxo-acid-lyases |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Citrate (pro-3S)-lyase |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Bisphosphomevalonate decarboxylase || Diphosphomevalonate decarboxylase || 3-hexulose-6-phosphate synthase |
| RmlC-like cupins | 1 | INHERITED FROM: Oxalate decarboxylase || Peptidyl-glutamate 4-carboxylase |
| Molybdenum cofactor biosynthesis protein C, MoaC | 1 | INHERITED FROM: Other carbon-carbon lyases || GTP 3',8-cyclase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Aldehyde oxygenase (deformylating) || UDP-glucuronate decarboxylase || Malolactic enzyme |
| Periplasmic binding protein-like II | 1 | INHERITED FROM: Prephenate decarboxylase |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| RraA-like | 0 | Direct |
| CoaB-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| MK0786-like | 0 | Direct |
| UbiD C-terminal domain-like | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| ADC synthase | 0 | Direct |
| Aldolase | 0 | Direct |
| RibA-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| AF0104/ALDC/Ptd012-like | 0 | Direct |
| ADC-like | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| UraD-Like | 0 | Direct |
| PLP-dependent transferases | 0.0000000000001165 | Direct |
| DHS-like NAD/FAD-binding domain | 0.000000000008713 | Direct |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.0000000495 | Direct |
| Tautomerase/MIF | 0.000000627 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.000003475 | Direct |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0001075 | Direct |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.003546 | Inherited |
| Rudiment single hybrid motif | 0.06045 | Inherited |
| CoA-dependent acyltransferases | 0.1925 | Inherited |
| PFL-like glycyl radical enzymes | 0.2216 | Inherited |
| 2-methylcitrate dehydratase PrpD | 0.623 | Inherited |
| FAH | 0.7078 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9191 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Ferritin-like | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| Dihydropteroate synthetase-like | 1 | Inherited |
| CheY-like | 1 | Inherited |
| Flavoproteins | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| AraD/HMP-PK domain-like | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| PRTase-like | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Ribosomal protein S5 domain 2-like | 1 | Inherited |
| RmlC-like cupins | 1 | Inherited |
| Molybdenum cofactor biosynthesis protein C, MoaC | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Periplasmic binding protein-like II | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| RraA-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Mevalonate 5-diphosphate decarboxylase | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Class II FBP aldolase | 0 | DIRECT |
| Ornithine decarboxylase N-terminal "wing" domain | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| HMGL-like | 0 | DIRECT |
| Ornithine decarboxylase major domain | 0 | DIRECT |
| Tryptophan biosynthesis enzymes | 0 | DIRECT |
| Beta-eliminating lyases | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| Pyruvate oxidase and decarboxylase PP module | 0 | DIRECT |
| PMT1231-like | 0 | DIRECT |
| MK0786-like | 0 | DIRECT |
| UraD-like | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Chorismate lyase | 0 | DIRECT |
| DmpG/LeuA communication domain-like | 0 | DIRECT |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | DIRECT |
| Arginine decarboxylase | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
| Uroporphyrinogen decarboxylase, UROD | 0 | DIRECT |
| HpcH/HpaI aldolase | 0 | DIRECT |
| Alpha-acetolactate decarboxylase-like | 0 | DIRECT |
| Pyruvate oxidase and decarboxylase, middle domain | 0 | DIRECT |
| UbiD middle domain-like | 0 | DIRECT |
| UbiD C-terminal domain-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| MoCo biosynthesis proteins | 0 | DIRECT |
| Decarboxylase | 0 | DIRECT |
| Histidine decarboxylase | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| Bacterial S-adenosylmethionine decarboxylase | 0 | DIRECT |
| RuBisCo, large subunit, C-terminal domain | 0 | DIRECT |
| Phosphoenolpyruvate carboxylase | 0 | DIRECT |
| DHN aldolase/epimerase | 0 | DIRECT |
| Pyruvate oxidase and decarboxylase Pyr module | 0.00000000000003435 | DIRECT |
| PP1699/LP2961-like | 0.0000000000001296 | DIRECT |
| MIF-related | 0.00000001698 | DIRECT |
| Formaldehyde-activating enzyme, FAE | 0.0000001683 | DIRECT |
| 6-pyruvoyl tetrahydropterin synthase | 0.000006883 | DIRECT |
| Germin/Seed storage 7S protein | 0.00001275 | DIRECT |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0001277 | DIRECT |
| CAT-like | 0.009919 | INHERITED FROM: Carboxy-lyases || 2-oxoglutarate decarboxylase |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.01136 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| PFL-like | 0.01179 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.01221 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| CoA transferase alpha subunit-like | 0.01588 | INHERITED FROM: Oxo-acid-lyases || Citrate (pro-3S)-lyase |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0.02879 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| Dihydropteroate synthetase | 0.03139 | INHERITED FROM: Aldehyde-lyases || Dihydroneopterin aldolase |
| BC C-terminal domain-like | 0.06807 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| GMC oxidoreductases | 0.07843 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| Cytochrome p450 reductase N-terminal domain-like | 0.1034 | INHERITED FROM: tRNA 4-demethylwyosine synthase (AdoMet-dependent) || Oxo-acid-lyases |
| Malic enzyme N-domain | 0.4563 | INHERITED FROM: Malolactic enzyme |
| 2-methylcitrate dehydratase PrpD | 0.5826 | INHERITED FROM: Carboxy-lyases || Cis-aconitate decarboxylase |
| FAH | 0.6223 | INHERITED FROM: Carboxy-lyases || Oxaloacetate decarboxylase || 2-oxo-3-hexenedioate decarboxylase || 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
| BC ATP-binding domain-like | 0.9185 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| BC N-terminal domain-like | 0.9637 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| FAD-linked reductases, N-terminal domain | 0.9776 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| AAT-like | 0.9791 | INHERITED FROM: Aldehyde-lyases || Low-specificity L-threonine aldolase || Threonine-phosphate decarboxylase |
| AraD-like aldolase/epimerase | 0.9891 | INHERITED FROM: Rhamnulose-1-phosphate aldolase || 3-dehydro-4-phosphotetronate decarboxylase || Aldehyde-lyases || L-fuculose-phosphate aldolase |
| GHMP Kinase, N-terminal domain | 1 | INHERITED FROM: Bisphosphomevalonate decarboxylase || Diphosphomevalonate decarboxylase |
| Class I glutamine amidotransferases (GAT) | 1 | INHERITED FROM: Indole-3-glycerol-phosphate synthase || Anthranilate synthase || Oxo-acid-lyases |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: UDP-glucuronate decarboxylase |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Malolactic enzyme |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | INHERITED FROM: Tartrate decarboxylase |
| Phosphoribosyltransferases (PRTases) | 1 | INHERITED FROM: Orotidine-5'-phosphate decarboxylase |
| Crotonase-like | 1 | INHERITED FROM: Ethylmalonyl-CoA decarboxylase || 1,4-dihydroxy-2-naphthoyl-CoA synthase || Oxo-acid-lyases |
| SAICAR synthase | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Molybdenum cofactor biosynthesis protein C, MoaC | 1 | INHERITED FROM: Other carbon-carbon lyases || GTP 3',8-cyclase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| RraA-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Mevalonate 5-diphosphate decarboxylase | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| Pyruvoyl dependent aspartate decarboxylase, ADC | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Class II FBP aldolase | 0 | Direct |
| Ornithine decarboxylase N-terminal "wing" domain | 0 | Direct |
| CoaB-like | 0 | Direct |
| HMGL-like | 0 | Direct |
| Ornithine decarboxylase major domain | 0 | Direct |
| Tryptophan biosynthesis enzymes | 0 | Direct |
| Beta-eliminating lyases | 0 | Direct |
| Class I aldolase | 0 | Direct |
| Pyruvate oxidase and decarboxylase PP module | 0 | Direct |
| PMT1231-like | 0 | Direct |
| MK0786-like | 0 | Direct |
| UraD-like | 0 | Direct |
| ADC synthase | 0 | Direct |
| RibA-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Chorismate lyase | 0 | Direct |
| DmpG/LeuA communication domain-like | 0 | Direct |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 0 | Direct |
| Arginine decarboxylase | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
| Uroporphyrinogen decarboxylase, UROD | 0 | Direct |
| HpcH/HpaI aldolase | 0 | Direct |
| Alpha-acetolactate decarboxylase-like | 0 | Direct |
| Pyruvate oxidase and decarboxylase, middle domain | 0 | Direct |
| UbiD middle domain-like | 0 | Direct |
| UbiD C-terminal domain-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| MoCo biosynthesis proteins | 0 | Direct |
| Decarboxylase | 0 | Direct |
| Histidine decarboxylase | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| Bacterial S-adenosylmethionine decarboxylase | 0 | Direct |
| RuBisCo, large subunit, C-terminal domain | 0 | Direct |
| Phosphoenolpyruvate carboxylase | 0 | Direct |
| DHN aldolase/epimerase | 0 | Direct |
| Pyruvate oxidase and decarboxylase Pyr module | 0.00000000000003435 | Direct |
| PP1699/LP2961-like | 0.0000000000001296 | Direct |
| MIF-related | 0.00000001698 | Direct |
| Formaldehyde-activating enzyme, FAE | 0.0000001683 | Direct |
| 6-pyruvoyl tetrahydropterin synthase | 0.000006883 | Direct |
| Germin/Seed storage 7S protein | 0.00001275 | Direct |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0001277 | Direct |
| CAT-like | 0.009919 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.01136 | Inherited |
| PFL-like | 0.01179 | Inherited |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.01221 | Inherited |
| CoA transferase alpha subunit-like | 0.01588 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0.02879 | Inherited |
| Dihydropteroate synthetase | 0.03139 | Inherited |
| BC C-terminal domain-like | 0.06807 | Inherited |
| GMC oxidoreductases | 0.07843 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.1034 | Inherited |
| Malic enzyme N-domain | 0.4563 | Inherited |
| 2-methylcitrate dehydratase PrpD | 0.5826 | Inherited |
| FAH | 0.6223 | Inherited |
| BC ATP-binding domain-like | 0.9185 | Inherited |
| BC N-terminal domain-like | 0.9637 | Inherited |
| FAD-linked reductases, N-terminal domain | 0.9776 | Inherited |
| AAT-like | 0.9791 | Inherited |
| AraD-like aldolase/epimerase | 0.9891 | Inherited |
| GHMP Kinase, N-terminal domain | 1 | Inherited |
| Class I glutamine amidotransferases (GAT) | 1 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 1 | Inherited |
| Phosphoribosyltransferases (PRTases) | 1 | Inherited |
| Crotonase-like | 1 | Inherited |
| SAICAR synthase | 1 | Inherited |
| Molybdenum cofactor biosynthesis protein C, MoaC | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Chorismate lyase-like | 0 | DIRECT |
| AF0104/ALDC/Ptd012-like | 0 | DIRECT |
| Acetoacetate decarboxylase-like | 0 | DIRECT |
| RraA-like | 0 | DIRECT |
| YrdC/RibB | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| UraD-Like | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | DIRECT |
| UbiD C-terminal domain-like | 0 | DIRECT |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| post-HMGL domain-like | 0 | DIRECT |
| UROD/MetE-like | 0 | DIRECT |
| S-adenosylmethionine decarboxylase | 0 | DIRECT |
| MK0786-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | DIRECT |
| RuBisCO, small subunit | 0 | DIRECT |
| RuBisCo, C-terminal domain | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| RibA-like | 0 | DIRECT |
| ADC synthase | 0 | DIRECT |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| PLP-dependent transferases | 0.00000000000008255 | DIRECT |
| DHS-like NAD/FAD-binding domain | 0.000000000006296 | DIRECT |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.00000003769 | DIRECT |
| Tautomerase/MIF | 0.0000004865 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.000002732 | DIRECT |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0000867 | DIRECT |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.002966 | INHERITED FROM: Oxo-acid-lyases || Aminodeoxychorismate lyase |
| Rudiment single hybrid motif | 0.0524 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| CoA-dependent acyltransferases | 0.1704 | INHERITED FROM: 2-oxoglutarate decarboxylase |
| PFL-like glycyl radical enzymes | 0.1969 | INHERITED FROM: 4-hydroxyphenylacetate decarboxylase |
| 2-methylcitrate dehydratase PrpD | 0.5717 | INHERITED FROM: Carboxy-lyases || Cis-aconitate decarboxylase |
| FAH | 0.6508 | INHERITED FROM: Carboxy-lyases || 2-oxo-3-hexenedioate decarboxylase || Oxaloacetate decarboxylase || 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.849 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Dihydropteroate synthetase-like | 0.9747 | INHERITED FROM: Dihydroneopterin aldolase |
| AraD/HMP-PK domain-like | 0.978 | INHERITED FROM: Aldehyde-lyases || 3-dehydro-4-phosphotetronate decarboxylase || Rhamnulose-1-phosphate aldolase || L-fuculose-phosphate aldolase |
| FAD-linked reductases, C-terminal domain | 0.9998 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
| PreATP-grasp domain | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| RmlC-like cupins | 1 | INHERITED FROM: Oxalate decarboxylase || Peptidyl-glutamate 4-carboxylase |
| ClpP/crotonase | 1 | INHERITED FROM: Oxo-acid-lyases || 1,4-dihydroxy-2-naphthoyl-CoA synthase || Ethylmalonyl-CoA decarboxylase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Citrate (pro-3S)-lyase |
| GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
| EF-hand | 1 | INHERITED FROM: Phosphatidylserine decarboxylase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Periplasmic binding protein-like II | 1 | INHERITED FROM: Prephenate decarboxylase |
| CheY-like | 1 | INHERITED FROM: Ornithine decarboxylase |
| Molybdenum cofactor biosynthesis protein C, MoaC | 1 | INHERITED FROM: Other carbon-carbon lyases || GTP 3',8-cyclase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Aminocarboxymuconate-semialdehyde decarboxylase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Aldehyde oxygenase (deformylating) || Malolactic enzyme || UDP-glucuronate decarboxylase |
| PRTase-like | 1 | INHERITED FROM: Orotidine-5'-phosphate decarboxylase |
| SAICAR synthase-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Ferritin-like | 1 | INHERITED FROM: Aldehyde oxygenase (deformylating) |
| Flavoproteins | 1 | INHERITED FROM: Oxo-acid-lyases || tRNA 4-demethylwyosine synthase (AdoMet-dependent) |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Bisphosphomevalonate decarboxylase || 3-hexulose-6-phosphate synthase || Diphosphomevalonate decarboxylase |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | INHERITED FROM: Tartrate decarboxylase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Oxo-acid-lyases || Indole-3-glycerol-phosphate synthase || Anthranilate synthase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: (R)-mandelonitrile lyase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Malolactic enzyme |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Chorismate lyase-like | 0 | Direct |
| AF0104/ALDC/Ptd012-like | 0 | Direct |
| Acetoacetate decarboxylase-like | 0 | Direct |
| RraA-like | 0 | Direct |
| YrdC/RibB | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Aldolase | 0 | Direct |
| UraD-Like | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| RuBisCO, large subunit, small (N-terminal) domain | 0 | Direct |
| UbiD C-terminal domain-like | 0 | Direct |
| Sulfolobus fructose-1,6-bisphosphatase-like | 0 | Direct |
| Ornithine decarboxylase C-terminal domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| ADC-like | 0 | Direct |
| post-HMGL domain-like | 0 | Direct |
| UROD/MetE-like | 0 | Direct |
| S-adenosylmethionine decarboxylase | 0 | Direct |
| MK0786-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0 | Direct |
| RuBisCO, small subunit | 0 | Direct |
| RuBisCo, C-terminal domain | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| RibA-like | 0 | Direct |
| ADC synthase | 0 | Direct |
| Pyruvoyl-dependent histidine and arginine decarboxylases | 0 | Direct |
| CoaB-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| PLP-dependent transferases | 0.00000000000008255 | Direct |
| DHS-like NAD/FAD-binding domain | 0.000000000006296 | Direct |
| Tetrahydrobiopterin biosynthesis enzymes-like | 0.00000003769 | Direct |
| Tautomerase/MIF | 0.0000004865 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.000002732 | Direct |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0.0000867 | Direct |
| D-aminoacid aminotransferase-like PLP-dependent enzymes | 0.002966 | Inherited |
| Rudiment single hybrid motif | 0.0524 | Inherited |
| CoA-dependent acyltransferases | 0.1704 | Inherited |
| PFL-like glycyl radical enzymes | 0.1969 | Inherited |
| 2-methylcitrate dehydratase PrpD | 0.5717 | Inherited |
| FAH | 0.6508 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.849 | Inherited |
| Dihydropteroate synthetase-like | 0.9747 | Inherited |
| AraD/HMP-PK domain-like | 0.978 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.9998 | Inherited |
| PreATP-grasp domain | 1 | Inherited |
| RmlC-like cupins | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| GHMP Kinase, C-terminal domain | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
| Periplasmic binding protein-like II | 1 | Inherited |
| CheY-like | 1 | Inherited |
| Molybdenum cofactor biosynthesis protein C, MoaC | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| PRTase-like | 1 | Inherited |
| SAICAR synthase-like | 1 | Inherited |
| Ferritin-like | 1 | Inherited |
| Flavoproteins | 1 | Inherited |
| Ribosomal protein S5 domain 2-like | 1 | Inherited |
| Isocitrate/Isopropylmalate dehydrogenase-like | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
50475,143968
50475 - FMN-binding split barrel
143968 - UbiD C-terminal domain-like | 0 | DIRECT |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
56529,56529
56529 - FAH
56529 - FAH | 0 | DIRECT |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | DIRECT |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | DIRECT |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | DIRECT |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | DIRECT |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | DIRECT |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0.000004196 | DIRECT |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.000231 | DIRECT |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.0006783 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.002891 | INHERITED FROM: Oxo-acid-lyases || Citrate (pro-3S)-lyase |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.0524 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.9559 | INHERITED FROM: Aldehyde-lyases || (R)-mandelonitrile lyase |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.9586 | INHERITED FROM: 2-oxoglutarate decarboxylase |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | INHERITED FROM: Diphosphomevalonate decarboxylase |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52172,53383
52172 - CheY-like
53383 - PLP-dependent transferases | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
56322,52317
56322 - ADC synthase
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
50475,143968
50475 - FMN-binding split barrel
143968 - UbiD C-terminal domain-like | 0 | Direct |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
51246,52255
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
53383,55904
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
56529,56529
56529 - FAH
56529 - FAH | 0 | Direct |
52317,47648
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | 0 | Direct |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 0 | Direct |
52518,52467
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0 | Direct |
53271,51366
53271 - PRTase-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 0 | Direct |
52467,52518
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
55821,142695
55821 - YrdC/RibB
142695 - RibA-like | 0 | Direct |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0.000004196 | Direct |
55083,51717
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0.000231 | Direct |
55620,55620
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like | 0.0006783 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.002891 | Inherited |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.0524 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.9559 | Inherited |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0.9586 | Inherited |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 1 | Inherited |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | DIRECT |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | DIRECT |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | DIRECT |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.05092 | INHERITED FROM: Phosphoribosylaminoimidazole carboxylase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56059,51246,52255
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
55620,55083,51717
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
51717 - Dihydropteroate synthetase-like | 0 | Direct |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
52518,52467,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52467 - DHS-like NAD/FAD-binding domain
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
52317,47648,52418
52317 - Class I glutamine amidotransferase-like
47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 0 | Direct |
52172,53383,55904
52172 - CheY-like
53383 - PLP-dependent transferases
55904 - Ornithine decarboxylase C-terminal domain | 0 | Direct |
55620,55620,55083
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55620 - Tetrahydrobiopterin biosynthesis enzymes-like
55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.05092 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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