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  Home > Phenotype Ontology > Oxo-acid-lyases

Enzyme Commission (EC): Oxo-acid-lyases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Lyases [4] <8>(182|225) (183|104|38)
+ 1:   Carbon-carbon lyases [4.1] <4>(71|84) (71|30|8)
0:   Oxo-acid-lyases [4.1.3] <47>(13|14) (13|6|2)
- 1:   (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase [4.1.3.35](0|0) (0|0|0)
- 1:   (4S)-4-hydroxy-2-oxoglutarate aldolase [4.1.3.42](0|0) (0|0|0)
- 1:   (R)-citramalyl-CoA lyase [4.1.3.46](0|0) (0|0|0)
- 1:   (S)-citramalyl-CoA lyase [4.1.3.25](1|1) (1|0|0)
- 1:   1,4-dihydroxy-2-naphthoyl-CoA synthase [4.1.3.36](1|1) (1|0|0)
- 1:   2,3-dimethylmalate lyase [4.1.3.32](0|0) (0|0|0)
- 1:   3-hydroxy-3-isohexenylglutaryl-CoA lyase [4.1.3.26](0|0) (0|0|0)
- 1:   3-hydroxy-D-aspartate aldolase [4.1.3.41](0|0) (0|0|0)
- 1:   3-hydroxybenzoate synthase [4.1.3.45](0|0) (0|0|0)
- 1:   4-hydroxy-2-oxoglutarate aldolase [4.1.3.16](1|1) (1|0|0)
- 1:   4-hydroxy-2-oxohexanoate aldolase [4.1.3.43](0|0) (0|0|0)
- 1:   4-hydroxy-2-oxovalerate aldolase [4.1.3.39](2|2) (2|1|0)
- 1:   4-hydroxy-4-methyl-2-oxoglutarate aldolase [4.1.3.17](1|1) (1|0|0)
- 1:   Aminodeoxychorismate lyase [4.1.3.38](1|1) (1|0|0)
- 1:   Anthranilate synthase [4.1.3.27](3|3) (3|4|2)
- 1:   Chorismate lyase [4.1.3.40](1|1) (1|0|0)
- 1:   Citramalate lyase [4.1.3.22](0|0) (0|0|0)
- 1:   Citrate (pro-3S)-lyase [4.1.3.6](1|2) (1|1|0)
- 1:   Citryl-CoA lyase [4.1.3.34](1|1) (1|0|0)
- 1:   Hydroxymethylglutaryl-CoA lyase [4.1.3.4](1|1) (1|0|0)
- 1:   Isocitrate lyase [4.1.3.1](1|1) (1|0|0)
- 1:   L-erythro-3-hydroxyaspartate aldolase [4.1.3.14](0|0) (0|0|0)
- 1:   Malyl-CoA lyase [4.1.3.24](1|1) (1|0|0)
- 1:   Methylisocitrate lyase [4.1.3.30](1|1) (1|0|0)
- 1:   N-acetylneuraminate lyase [4.1.3.3](1|1) (1|0|0)
- 1:   Oxalomalate lyase [4.1.3.13](0|0) (0|0|0)
- 1:   Transferred entry: 2.2.1.5 [4.1.3.15](0|0) (0|0|0)
- 1:   Transferred entry: 2.2.1.6 [4.1.3.18](0|0) (0|0|0)
- 1:   Transferred entry: 2.2.1.7 [4.1.3.37](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.1 [4.1.3.7](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.10 [4.1.3.5](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.11 [4.1.3.9](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.12 [4.1.3.11](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.13 [4.1.3.12](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.14 [4.1.3.21](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.2 [4.1.3.23](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.3 [4.1.3.28](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.4 [4.1.3.29](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.5 [4.1.3.31](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.6 [4.1.3.33](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.7 [4.1.3.10](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.8 [4.1.3.8](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.3.9 [4.1.3.2](0|0) (0|0|0)
- 1:   Transferred entry: 2.5.1.56 [4.1.3.19](0|0) (0|0|0)
- 1:   Transferred entry: 2.5.1.57 [4.1.3.20](0|0) (0|0|0)
- 1:   Transferred entry: 4.1.3.43 [4.1.3.n1](0|0) (0|0|0)
- 1:   tRNA 4-demethylwyosine synthase (AdoMet-dependent) [4.1.3.44](2|1) (2|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
RraA-like0Direct
post-HMGL domain-like0Direct
ADC synthase0Direct
Aldolase0Direct
Class I glutamine amidotransferase-like0Direct
Chorismate lyase-like0Direct
D-aminoacid aminotransferase-like PLP-dependent enzymes0.0000000007191Direct
Phosphoenolpyruvate/pyruvate domain0.00000009911Direct
Flavoproteins0.00001977Direct
ClpP/crotonase0.0003827Direct
NagB/RpiA/CoA transferase-like0.3268Inherited
Radical SAM enzymes1Inherited
Ribulose-phoshate binding barrel1Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
RraA-like0Direct
Phosphoenolpyruvate mutase/Isocitrate lyase-like0Direct
HMGL-like0Direct
Class I glutamine amidotransferases (GAT)0Direct
ADC synthase0Direct
Chorismate lyase0Direct
DmpG/LeuA communication domain-like0Direct
Crotonase-like0.000000004185Direct
D-aminoacid aminotransferase-like PLP-dependent enzymes0.00000001812Direct
Cytochrome p450 reductase N-terminal domain-like0.0000004409Direct
CoA transferase alpha subunit-like0.0000008352Direct
HpcH/HpaI aldolase0.008202Inherited
Class I aldolase0.4965Inherited
Tryptophan biosynthesis enzymes1Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Chorismate lyase-like0Direct
RraA-like0Direct
Aldolase0Direct
post-HMGL domain-like0Direct
ADC synthase0Direct
Class I glutamine amidotransferase-like0Direct
D-aminoacid aminotransferase-like PLP-dependent enzymes0.0000000005341Direct
Phosphoenolpyruvate/pyruvate domain0.00000007571Direct
Flavoproteins0.00001575Direct
ClpP/crotonase0.0003118Direct
NagB/RpiA/CoA transferase-like0.2953Inherited
Radical SAM enzymes1Inherited
Ribulose-phoshate binding barrel1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56322,52317
  • 56322 - ADC synthase
  • 52317 - Class I glutamine amidotransferase-like
    		• 0Direct
    52317,47648
  • 52317 - Class I glutamine amidotransferase-like
  • 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
    		• 0Direct
    52317,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
    		• 0Direct
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
    		• 0Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
    		• 0.0000001142Direct
    51366,51366
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
    		• 0.00001283Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52317,51366,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
    		• 0Direct
    52317,47648,52418
  • 52317 - Class I glutamine amidotransferase-like
  • 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
  • 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
    		• 0Direct

    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)
    Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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    © Copyright 2013 The SUPERFAMILY authors and Julian Gough.