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Enzyme Commission (EC): Carbon-oxygen lyases
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PCD-like | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Lysozyme-like | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Chondroitin AC/alginate lyase | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Indigoidine synthase A-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| IlvD/EDD N-terminal domain-like | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| AttH-like | 0 | DIRECT |
| Prokaryotic type KH domain (KH-domain type II) | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| YjeF N-terminal domain-like | 0.0000000000001663 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000000004869 | DIRECT |
| Ribokinase-like | 0.000000000005454 | DIRECT |
| Starch-binding domain-like | 0.00000000008802 | DIRECT |
| Electron transport accessory proteins | 0.000000002626 | DIRECT |
| Chorismate mutase II | 0.000000006424 | DIRECT |
| TATA-box binding protein-like | 0.00000005336 | DIRECT |
| Galactose mutarotase-like | 0.0000003408 | DIRECT |
| HSP20-like chaperones | 0.00008667 | DIRECT |
| Barwin-like endoglucanases | 0.0001891 | DIRECT |
| DNase I-like | 0.0007123 | DIRECT |
| SCP-like | 0.001621 | INHERITED FROM: hydratase || Hydro-lyases || Enoyl-CoA hydratase 2 |
| 2-methylcitrate dehydratase PrpD | 0.007637 | INHERITED FROM: Hydro-lyases || 2-methylcitrate dehydratase || Aconitate hydratase |
| Cytochrome P450 | 0.03005 | INHERITED FROM: Hydroperoxide dehydratase || Colneleate synthase || Hydro-lyases || Hydroperoxy icosatetraenoate dehydratase |
| CBS-domain pair | 0.03689 | INHERITED FROM: Cystathionine beta-synthase |
| Ran binding protein zinc finger-like | 0.0616 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| FAH | 0.09093 | INHERITED FROM: Hydro-lyases || 2-oxopent-4-enoate hydratase |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1387 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| FabD/lysophospholipase-like | 0.1397 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Carbon-nitrogen hydrolase | 0.1883 | INHERITED FROM: 3-cyanoalanine hydratase || Cyanide hydratase |
| ACP-like | 0.2215 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| NTF2-like | 0.2215 | INHERITED FROM: Scytalone dehydratase |
| HAD-like | 0.2872 | INHERITED FROM: Imidazoleglycerol-phosphate dehydratase || Methylthioribulose 1-phosphate dehydratase |
| Bet v1-like | 0.302 | INHERITED FROM: (S)-norcoclaurine synthase |
| ACT-like | 0.3148 | INHERITED FROM: Prephenate dehydratase || Arogenate dehydratase |
| Lipoxigenase | 0.3599 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| Diaminopimelate epimerase-like | 0.3705 | INHERITED FROM: Trans-L-3-hydroxyproline dehydratase |
| EPT/RTPC-like | 0.376 | INHERITED FROM: Acting on phosphates || 3-dehydroquinate synthase || 3-dehydroquinate dehydratase |
| Galactose-binding domain-like | 0.4158 | INHERITED FROM: Acting on polysaccharides || Chondroitin-sulfate-ABC exolyase || Rhamnogalacturonan endolyase |
| UBA-like | 0.4281 | INHERITED FROM: N-acetylmuramic acid 6-phosphate etherase |
| SMAD/FHA domain | 0.4811 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.7352 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| RmlC-like cupins | 0.804 | INHERITED FROM: Ectoine synthase || Hydro-lyases |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.9294 | INHERITED FROM: Acting on phosphates || 3-dehydroquinate synthase || 3-dehydroquinate dehydratase |
| Triosephosphate isomerase (TIM) | 0.9932 | INHERITED FROM: Acting on phosphates || Methylglyoxal synthase |
| L-aspartase-like | 1 | INHERITED FROM: Fumarate hydratase || Hydro-lyases |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: Tuliposide A-converting enzyme || 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase || Other carbon-oxygen lyases |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Oleate hydratase |
| PLP-dependent transferases | 1 | INHERITED FROM: Ethanolamine-phosphate phospho-lyase |
| Aldolase | 1 | INHERITED FROM: 5-dehydro-4-deoxyglucarate dehydratase || 3-dehydroquinate synthase || Porphobilinogen synthase || 3-dehydroquinate dehydratase || Hydro-lyases || (5-formylfuran-3-yl)methyl phosphate synthase |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: 6-pyruvoyltetrahydropterin synthase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: D-lactate dehydratase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: 3-dehydroquinate synthase |
| Ribulose-phoshate binding barrel | 1 | INHERITED FROM: Tryptophan synthase || 5,6,7,8-tetrahydromethanopterin hydro-lyase || Hydro-lyases || (5-formylfuran-3-yl)methyl phosphate synthase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Enoyl-CoA hydratase || hydratase || dTDP-glucose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Enoyl-CoA hydratase 2 |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HCDH C-domain-like | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, middle domain | 0 | DIRECT |
| D-glucarate dehydratase-like | 0 | DIRECT |
| Terpenoid cyclase N-terminal domain | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| UxuA-like | 0 | DIRECT |
| Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| IlvD/EDD C-terminal domain-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Scytalone dehydratase | 0 | DIRECT |
| Bacterial muramidase, catalytic domain | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| Terpenoid cyclase C-terminal domain | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | DIRECT |
| FabZ-like | 0 | DIRECT |
| C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | DIRECT |
| lvD/EDD N-terminal domain-like | 0 | DIRECT |
| Cyanase N-terminal domain | 0 | DIRECT |
| Hyaluronate lyase-like, central domain | 0 | DIRECT |
| Nitrile hydratase beta chain | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| Aristolochene/pentalenene synthase | 0 | DIRECT |
| Dimeric chorismate mutase | 0 | DIRECT |
| YjeF C-terminal domain-like | 0 | DIRECT |
| Hypothetical protein VC1974 | 0 | DIRECT |
| Dehydroquinate synthase, DHQS | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | DIRECT |
| MaoC-like | 0 | DIRECT |
| AttH-like | 0 | DIRECT |
| mono-SIS domain | 0 | DIRECT |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | DIRECT |
| Hyaluronate lyase-like catalytic, N-terminal domain | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Alginate lyase A1-III | 0 | DIRECT |
| MLTA-like | 0 | DIRECT |
| Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | DIRECT |
| Formaldehyde-activating enzyme, FAE | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| Trichodiene synthase | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Methylglyoxal synthase, MgsA | 0 | DIRECT |
| Prokaryotic type KH domain (KH-domain type II) | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| Pectate lyase-like | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Endonuclease III | 0 | DIRECT |
| Enolase | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| Indigoidine synthase A-like | 0 | DIRECT |
| AgoG-like | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Middle domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Pectate transeliminase | 0 | DIRECT |
| Pectin lyase | 0 | DIRECT |
| Chondroitin ABC lyase I, N-terminal domain | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0 | DIRECT |
| Phosphate binding protein-like | 5.532e-16 | DIRECT |
| Shikimate kinase (AroK) | 0.000000000000001463 | DIRECT |
| DNase I-like | 0.00000000000001797 | DIRECT |
| Proline racemase | 0.0000000000001325 | DIRECT |
| YjeF N-terminal domain-like | 0.0000000000005668 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0.000000000002454 | DIRECT |
| Nitrile hydratase alpha chain | 0.000000000006128 | DIRECT |
| Shikimate dehydrogenase-like | 0.00000000002744 | DIRECT |
| Tryptophan biosynthesis enzymes | 0.00000001882 | DIRECT |
| Co-chaperone p23-like | 0.00000006216 | DIRECT |
| DNA repair glycosylase, N-terminal domain | 0.00000006216 | DIRECT |
| DNA repair glycosylase, 2 C-terminal domains | 0.0000002264 | DIRECT |
| Acyl-carrier protein (ACP) | 0.0000002309 | DIRECT |
| DJ-1/PfpI | 0.000007246 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.0001042 | DIRECT |
| FabD-like | 0.000178 | DIRECT |
| Carboxylesterase | 0.0008217 | DIRECT |
| Sterol carrier protein, SCP | 0.001689 | INHERITED FROM: hydratase || Hydro-lyases || Enoyl-CoA hydratase 2 |
| 2-methylcitrate dehydratase PrpD | 0.006482 | INHERITED FROM: Hydro-lyases || 2-methylcitrate dehydratase || Aconitate hydratase |
| Animal lipoxigenases | 0.008202 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| Terpene synthases | 0.02332 | INHERITED FROM: Squalene--hopanol cyclase |
| CBS-domain pair | 0.03615 | INHERITED FROM: Cystathionine beta-synthase |
| Ran binding protein zinc finger-like | 0.06445 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| Cytochrome P450 | 0.07241 | INHERITED FROM: Hydroperoxide dehydratase || Colneleate synthase || Hydro-lyases || Hydroperoxy icosatetraenoate dehydratase |
| FAH | 0.1044 | INHERITED FROM: Hydro-lyases || 2-oxopent-4-enoate hydratase |
| Tyrosine-dependent oxidoreductases | 0.1505 | INHERITED FROM: hydratase || dTDP-glucose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || UDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || Hydro-lyases || Enoyl-CoA hydratase 2 |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1895 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Enolase-phosphatase E1 | 0.2741 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase |
| Enolpyruvate transferase, EPT | 0.2803 | INHERITED FROM: Acting on phosphates || 3-dehydroquinate synthase || 3-dehydroquinate dehydratase |
| Lipoxigenase N-terminal domain | 0.4143 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| FHA domain | 0.4542 | INHERITED FROM: DNA-(apurinic or apyrimidinic site) lyase || Other carbon-oxygen lyases |
| Triosephosphate isomerase (TIM) | 0.9886 | INHERITED FROM: Acting on phosphates || Methylglyoxal synthase |
| 6-pyruvoyl tetrahydropterin synthase | 0.9924 | INHERITED FROM: Acting on phosphates || 6-pyruvoyltetrahydropterin synthase |
| Thiolase-related | 1 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Class I aldolase | 1 | INHERITED FROM: 5-dehydro-4-deoxyglucarate dehydratase || 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Hydro-lyases |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase |
| L-aspartase/fumarase | 1 | INHERITED FROM: Fumarate hydratase || Hydro-lyases |
| GABA-aminotransferase-like | 1 | INHERITED FROM: Ethanolamine-phosphate phospho-lyase |
| Decarboxylase | 1 | INHERITED FROM: 5,6,7,8-tetrahydromethanopterin hydro-lyase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HCDH C-domain-like | 0 | Direct |
| Rhamnogalacturonase B, RhgB, middle domain | 0 | Direct |
| D-glucarate dehydratase-like | 0 | Direct |
| Terpenoid cyclase N-terminal domain | 0 | Direct |
| Cyanase C-terminal domain | 0 | Direct |
| UxuA-like | 0 | Direct |
| Ribosomal protein S3 C-terminal domain | 0 | Direct |
| Bacterial muramidases | 0 | Direct |
| IlvD/EDD C-terminal domain-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Scytalone dehydratase | 0 | Direct |
| Bacterial muramidase, catalytic domain | 0 | Direct |
| FumA C-terminal domain-like | 0 | Direct |
| Terpenoid cyclase C-terminal domain | 0 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | Direct |
| FabZ-like | 0 | Direct |
| C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | Direct |
| lvD/EDD N-terminal domain-like | 0 | Direct |
| Cyanase N-terminal domain | 0 | Direct |
| Hyaluronate lyase-like, central domain | 0 | Direct |
| Nitrile hydratase beta chain | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| Aristolochene/pentalenene synthase | 0 | Direct |
| Dimeric chorismate mutase | 0 | Direct |
| YjeF C-terminal domain-like | 0 | Direct |
| Hypothetical protein VC1974 | 0 | Direct |
| Dehydroquinate synthase, DHQS | 0 | Direct |
| LeuD-like | 0 | Direct |
| Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | Direct |
| MaoC-like | 0 | Direct |
| AttH-like | 0 | Direct |
| mono-SIS domain | 0 | Direct |
| 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | Direct |
| Hyaluronate lyase-like catalytic, N-terminal domain | 0 | Direct |
| HemD-like | 0 | Direct |
| Alginate lyase A1-III | 0 | Direct |
| MLTA-like | 0 | Direct |
| Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | Direct |
| Formaldehyde-activating enzyme, FAE | 0 | Direct |
| Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
| N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
| Chorismate synthase, AroC | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Type II 3-dehydroquinate dehydratase | 0 | Direct |
| Trichodiene synthase | 0 | Direct |
| Crotonase-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Methylglyoxal synthase, MgsA | 0 | Direct |
| Prokaryotic type KH domain (KH-domain type II) | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| Pectate lyase-like | 0 | Direct |
| PCD-like | 0 | Direct |
| Endonuclease III | 0 | Direct |
| Enolase | 0 | Direct |
| Urocanase | 0 | Direct |
| Indigoidine synthase A-like | 0 | Direct |
| AgoG-like | 0 | Direct |
| beta-carbonic anhydrase, cab | 0 | Direct |
| Middle domain of MutM-like DNA repair proteins | 0 | Direct |
| Pectate transeliminase | 0 | Direct |
| Pectin lyase | 0 | Direct |
| Chondroitin ABC lyase I, N-terminal domain | 0 | Direct |
| Aconitase B, N-terminal domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Imidazole glycerol phosphate dehydratase | 0 | Direct |
| Phosphate binding protein-like | 5.532e-16 | Direct |
| Shikimate kinase (AroK) | 0.000000000000001463 | Direct |
| DNase I-like | 0.00000000000001797 | Direct |
| Proline racemase | 0.0000000000001325 | Direct |
| YjeF N-terminal domain-like | 0.0000000000005668 | Direct |
| Phenylalanine metabolism regulatory domain | 0.000000000002454 | Direct |
| Nitrile hydratase alpha chain | 0.000000000006128 | Direct |
| Shikimate dehydrogenase-like | 0.00000000002744 | Direct |
| Tryptophan biosynthesis enzymes | 0.00000001882 | Direct |
| Co-chaperone p23-like | 0.00000006216 | Direct |
| DNA repair glycosylase, N-terminal domain | 0.00000006216 | Direct |
| DNA repair glycosylase, 2 C-terminal domains | 0.0000002264 | Direct |
| Acyl-carrier protein (ACP) | 0.0000002309 | Direct |
| DJ-1/PfpI | 0.000007246 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.0001042 | Direct |
| FabD-like | 0.000178 | Direct |
| Carboxylesterase | 0.0008217 | Direct |
| Sterol carrier protein, SCP | 0.001689 | Inherited |
| 2-methylcitrate dehydratase PrpD | 0.006482 | Inherited |
| Animal lipoxigenases | 0.008202 | Inherited |
| Terpene synthases | 0.02332 | Inherited |
| CBS-domain pair | 0.03615 | Inherited |
| Ran binding protein zinc finger-like | 0.06445 | Inherited |
| Cytochrome P450 | 0.07241 | Inherited |
| FAH | 0.1044 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.1505 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1895 | Inherited |
| Enolase-phosphatase E1 | 0.2741 | Inherited |
| Enolpyruvate transferase, EPT | 0.2803 | Inherited |
| Lipoxigenase N-terminal domain | 0.4143 | Inherited |
| FHA domain | 0.4542 | Inherited |
| Triosephosphate isomerase (TIM) | 0.9886 | Inherited |
| 6-pyruvoyl tetrahydropterin synthase | 0.9924 | Inherited |
| Thiolase-related | 1 | Inherited |
| Class I aldolase | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
| L-aspartase/fumarase | 1 | Inherited |
| GABA-aminotransferase-like | 1 | Inherited |
| Decarboxylase | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Lysozyme-like | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Dehydroquinate synthase-like | 0 | DIRECT |
| Chondroitin AC/alginate lyase | 0 | DIRECT |
| AttH-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
| Aconitase B, N-terminal domain | 0 | DIRECT |
| beta-carbonic anhydrase, cab | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| IlvD/EDD N-terminal domain-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| PCD-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| Bacterial muramidases | 0 | DIRECT |
| FumA C-terminal domain-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Cyanase C-terminal domain | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
| HemD-like | 0 | DIRECT |
| Prokaryotic type KH domain (KH-domain type II) | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Chorismate synthase, AroC | 0 | DIRECT |
| Indigoidine synthase A-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
| Urocanase | 0 | DIRECT |
| YjeF N-terminal domain-like | 0.000000000000118 | DIRECT |
| Nitrile hydratase alpha chain | 0.00000000000351 | DIRECT |
| Ribokinase-like | 0.000000000003932 | DIRECT |
| Starch-binding domain-like | 0.00000000006462 | DIRECT |
| Electron transport accessory proteins | 0.000000001965 | DIRECT |
| Chorismate mutase II | 0.000000004837 | DIRECT |
| TATA-box binding protein-like | 0.00000004063 | DIRECT |
| Galactose mutarotase-like | 0.0000002628 | DIRECT |
| HSP20-like chaperones | 0.00006978 | DIRECT |
| Barwin-like endoglucanases | 0.0001534 | DIRECT |
| DNase I-like | 0.0005851 | DIRECT |
| Integrin alpha N-terminal domain | 0.0008454 | DIRECT |
| SCP-like | 0.001344 | INHERITED FROM: Enoyl-CoA hydratase 2 || hydratase || Hydro-lyases |
| 2-methylcitrate dehydratase PrpD | 0.006443 | INHERITED FROM: 2-methylcitrate dehydratase || Aconitate hydratase || Hydro-lyases |
| Cytochrome P450 | 0.0258 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase || Hydro-lyases || Colneleate synthase || Hydroperoxide dehydratase |
| CBS-domain pair | 0.03171 | INHERITED FROM: Cystathionine beta-synthase |
| Ran binding protein zinc finger-like | 0.0534 | INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| FAH | 0.0792 | INHERITED FROM: 2-oxopent-4-enoate hydratase || Hydro-lyases |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1217 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| FabD/lysophospholipase-like | 0.1226 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Carbon-nitrogen hydrolase | 0.1666 | INHERITED FROM: Cyanide hydratase || 3-cyanoalanine hydratase |
| ACP-like | 0.1968 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| NTF2-like | 0.1968 | INHERITED FROM: Scytalone dehydratase |
| HAD-like | 0.2589 | INHERITED FROM: Imidazoleglycerol-phosphate dehydratase || Methylthioribulose 1-phosphate dehydratase || Hydro-lyases |
| Bet v1-like | 0.2725 | INHERITED FROM: (S)-norcoclaurine synthase |
| ACT-like | 0.2843 | INHERITED FROM: Prephenate dehydratase || Arogenate dehydratase |
| Lipoxigenase | 0.3256 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| Diaminopimelate epimerase-like | 0.3353 | INHERITED FROM: Trans-L-3-hydroxyproline dehydratase |
| EPT/RTPC-like | 0.3404 | INHERITED FROM: Acting on phosphates || 3-dehydroquinate dehydratase || 3-dehydroquinate synthase |
| Galactose-binding domain-like | 0.3773 | INHERITED FROM: Rhamnogalacturonan endolyase || Chondroitin-sulfate-ABC exolyase || Acting on polysaccharides |
| UBA-like | 0.389 | INHERITED FROM: N-acetylmuramic acid 6-phosphate etherase |
| SMAD/FHA domain | 0.4388 | INHERITED FROM: Other carbon-oxygen lyases || DNA-(apurinic or apyrimidinic site) lyase |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.6761 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
| RmlC-like cupins | 0.7403 | INHERITED FROM: Ectoine synthase || Hydro-lyases |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.8589 | INHERITED FROM: Acting on phosphates || 3-dehydroquinate dehydratase || 3-dehydroquinate synthase |
| Triosephosphate isomerase (TIM) | 0.92 | INHERITED FROM: Methylglyoxal synthase || Acting on phosphates |
| PLP-dependent transferases | 1 | INHERITED FROM: Ethanolamine-phosphate phospho-lyase |
| Aldolase | 1 | INHERITED FROM: Porphobilinogen synthase || (5-formylfuran-3-yl)methyl phosphate synthase || 5-dehydro-4-deoxyglucarate dehydratase || 3-dehydroquinate dehydratase || Hydro-lyases || 3-dehydroquinate synthase |
| L-aspartase-like | 1 | INHERITED FROM: Fumarate hydratase || Hydro-lyases |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase || Other carbon-oxygen lyases || Tuliposide A-converting enzyme |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: UDP-glucose 4,6-dehydratase || UDP-N-acetylglucosamine 4,6-dehydratase (inverting) || Enoyl-CoA hydratase || GDP-mannose 4,6-dehydratase || dTDP-glucose 4,6-dehydratase || Enoyl-CoA hydratase 2 || hydratase || 3-dehydroquinate dehydratase || 3-dehydroquinate synthase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: 3-dehydroquinate synthase |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: 6-pyruvoyltetrahydropterin synthase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: D-lactate dehydratase |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Oleate hydratase |
| Ribulose-phoshate binding barrel | 1 | INHERITED FROM: (5-formylfuran-3-yl)methyl phosphate synthase || 5,6,7,8-tetrahydromethanopterin hydro-lyase || Tryptophan synthase || Hydro-lyases |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
74650,49863
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | DIRECT |
49452,49785
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
53850,53955
53850 - Periplasmic binding protein-like II
53955 - Lysozyme-like | 0 | DIRECT |
48435,53955
48435 - Bacterial muramidases
53955 - Lysozyme-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | DIRECT |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
49785,48230
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase | 0 | DIRECT |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | DIRECT |
81624,46946
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain | 0 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
51569,51366
51569 - Aldolase
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
48576,48576
48576 - Terpenoid synthases
48576 - Terpenoid synthases | 0 | DIRECT |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | DIRECT |
54211,54637
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48230,74650
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | DIRECT |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
64153,53613
64153 - YjeF N-terminal domain-like
53613 - Ribokinase-like | 0 | DIRECT |
54814,54821
54814 - Prokaryotic type KH domain (KH-domain type II)
54821 - Ribosomal protein S3 C-terminal domain | 0 | DIRECT |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
46946,57716
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
74650,49452
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.00000000007867 | DIRECT |
55945,48150
55945 - TATA-box binding protein-like
48150 - DNA-glycosylase | 0.00000004063 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000004052 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000008787 | DIRECT |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00134 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase || Enoyl-CoA hydratase 2 || Hydro-lyases |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.01076 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
53686,-9
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
-9 - PDB | 0.05572 | INHERITED FROM: Tryptophan synthase || Hydro-lyases |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1217 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.2227 | INHERITED FROM: Hydroperoxy icosatetraenoate dehydratase |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0.5843 | INHERITED FROM: Acting on phosphates || 3-dehydroquinate dehydratase || 3-dehydroquinate synthase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
52540,51569
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
51366,53686
51366 - Ribulose-phoshate binding barrel
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | Direct |
52151,51412
52151 - FabD/lysophospholipase-like
51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
74650,49863
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
74778,52016
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like | 0 | Direct |
55205,52540
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
143975,52016
143975 - IlvD/EDD N-terminal domain-like
52016 - LeuD/IlvD-like | 0 | Direct |
49452,49785
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
52016,53732
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
53850,53955
53850 - Periplasmic binding protein-like II
53955 - Lysozyme-like | 0 | Direct |
48435,53955
48435 - Bacterial muramidases
53955 - Lysozyme-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
53686,54631
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
54631 - CBS-domain pair | 0 | Direct |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
49785,48230
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase | 0 | Direct |
54211,51366
54211 - Ribosomal protein S5 domain 2-like
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
56796,55205
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like | 0 | Direct |
81624,46946
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain | 0 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
53697,46934
53697 - SIS domain
46934 - UBA-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
51569,51366
51569 - Aldolase
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
48576,48576
48576 - Terpenoid synthases
48576 - Terpenoid synthases | 0 | Direct |
47413,55234
47413 - lambda repressor-like DNA-binding domains
55234 - Cyanase C-terminal domain | 0 | Direct |
54211,54637
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48230,74650
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | Direct |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
64153,53613
64153 - YjeF N-terminal domain-like
53613 - Ribokinase-like | 0 | Direct |
54814,54821
54814 - Prokaryotic type KH domain (KH-domain type II)
54821 - Ribosomal protein S3 C-terminal domain | 0 | Direct |
51569,53223
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
46946,57716
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
74650,49452
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.00000000007867 | Direct |
55945,48150
55945 - TATA-box binding protein-like
48150 - DNA-glycosylase | 0.00000004063 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.000004052 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000008787 | Direct |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00134 | Inherited |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.01076 | Inherited |
53686,-9
53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
-9 - PDB | 0.05572 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.1217 | Inherited |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.2227 | Inherited |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0.5843 | Inherited |
(show details)
Supra-domains annotated to this EC term (Not in SPEC)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | DIRECT |
49785,48230,74650
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | DIRECT |
81624,46946,57716
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54211,54211,54637
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48230,74650,49863
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
74650,49452,49785
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000002438 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000008787 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0001664 | DIRECT |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.007012 | INHERITED FROM: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,51569,53223
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
51735,51735,54637
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
55205,52540,51569
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51569 - Aldolase | 0 | Direct |
49785,48230,74650
49785 - Galactose-binding domain-like
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like | 0 | Direct |
81624,46946,57716
81624 - N-terminal domain of MutM-like DNA repair proteins
46946 - S13-like H2TH domain
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
51569,53223,51735
51569 - Aldolase
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54211,54211,54637
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
54637,54637,55718
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55718 - SCP-like | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48230,74650,49863
48230 - Chondroitin AC/alginate lyase
74650 - Galactose mutarotase-like
49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
56796,55205,52540
56796 - Dehydroquinate synthase-like
55205 - EPT/RTPC-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,54637,54637
51735 - NAD(P)-binding Rossmann-fold domains
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
74778,52016,53732
74778 - Aconitase B, N-terminal domain
52016 - LeuD/IlvD-like
53732 - Aconitase iron-sulfur domain | 0 | Direct |
74650,49452,49785
74650 - Galactose mutarotase-like
49452 - Starch-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000002438 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.000008787 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.0001664 | Direct |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.007012 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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