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  Home > Phenotype Ontology > Hydro-lyases

Enzyme Commission (EC): Hydro-lyases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Lyases [4] <8>(182|225) (183|104|38)
+ 1:   Carbon-oxygen lyases [4.2] <4>(87|105) (88|52|22)
0:   Hydro-lyases [4.2.1] <176>(61|70) (61|39|18)
- 1:   (+)-caryolan-1-ol synthase [4.2.1.138](0|0) (0|0|0)
- 1:   (R)-2-hydroxyglutaryl-CoA dehydratase [4.2.1.167](0|0) (0|0|0)
- 1:   (R)-2-hydroxyisocaproyl-CoA dehydratase [4.2.1.157](0|0) (0|0|0)
- 1:   (R)-2-methylmalate dehydratase [4.2.1.35](0|0) (0|0|0)
- 1:   (R)-synephrine [4.2.1.88](0|0) (0|0|0)
- 1:   (S)-2-methylmalate dehydratase [4.2.1.34](0|0) (0|0|0)
- 1:   (S)-norcoclaurine synthase [4.2.1.78](1|0) (1|0|0)
- 1:   1,5-anhydro-D-fructose dehydratase [4.2.1.111](0|0) (0|0|0)
- 1:   16-alpha-hydroxyprogesterone dehydratase [4.2.1.98](0|0) (0|0|0)
- 1:   2-(omega-methylthio)alkylmalate dehydratase [4.2.1.170](0|0) (0|0|0)
- 1:   2-dehydro-3-deoxy-D-arabinonate dehydratase [4.2.1.141](0|0) (0|0|0)
- 1:   2-dehydro-3-deoxy-L-arabinonate dehydratase [4.2.1.43](0|0) (0|0|0)
- 1:   2-hydroxyhexa-2,4-dienoate hydratase [4.2.1.132](0|0) (0|0|0)
- 1:   2-hydroxyisoflavanone dehydratase [4.2.1.105](0|0) (0|0|0)
- 1:   2-methylcitrate dehydratase [4.2.1.79](1|1) (1|0|0)
- 1:   2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) [4.2.1.117](0|0) (0|0|0)
- 1:   2-methylfumaryl-CoA hydratase [4.2.1.148](1|0) (1|0|0)
- 1:   2-methylisocitrate dehydratase [4.2.1.99](3|3) (3|3|1)
- 1:   2-oxo-hept-4-ene-1,7-dioate hydratase [4.2.1.163](0|0) (0|0|0)
- 1:   2-oxopent-4-enoate hydratase [4.2.1.80](1|1) (1|0|0)
- 1:   3-amino-5-hydroxybenzoate synthase [4.2.1.144](0|0) (0|0|0)
- 1:   3-cyanoalanine hydratase [4.2.1.65](1|0) (1|0|0)
- 1:   3-dehydroquinate dehydratase [4.2.1.10](6|7) (6|5|4)
- 1:   3-dehydroshikimate dehydratase [4.2.1.118](0|0) (0|0|0)
- 1:   3-hydroxyacyl-[acyl-carrier-protein] dehydratase [4.2.1.59](4|7) (4|7|4)
- 1:   3-hydroxybutyryl-CoA dehydratase [4.2.1.55](1|1) (1|0|0)
- 1:   3-hydroxypropionyl-CoA dehydratase [4.2.1.116](0|0) (0|0|0)
- 1:   3-isopropylmalate dehydratase [4.2.1.33](2|2) (2|0|0)
- 1:   3-methylfumaryl-CoA hydratase [4.2.1.153](0|0) (0|0|0)
- 1:   3-vinylbacteriochlorophyllide d 3(1)-hydratase [4.2.1.169](0|0) (0|0|0)
- 1:   4-hydroxybutanoyl-CoA dehydratase [4.2.1.120](0|0) (0|0|0)
- 1:   4-oxalmesaconate hydratase [4.2.1.83](0|0) (0|0|0)
- 1:   4a-hydroxytetrahydrobiopterin dehydratase [4.2.1.96](1|1) (1|0|0)
- 1:   5'-oxoaverantin cyclase [4.2.1.142](0|0) (0|0|0)
- 1:   5,6,7,8-tetrahydromethanopterin hydro-lyase [4.2.1.147](2|2) (2|1|0)
- 1:   5-alpha-hydroxysteroid dehydratase [4.2.1.62](0|0) (0|0|0)
- 1:   5-dehydro-4-deoxyglucarate dehydratase [4.2.1.41](1|1) (1|0|0)
- 1:   6-deoxy-6-sulfo-D-gluconate dehydratase [4.2.1.162](0|0) (0|0|0)
- 1:   ADP-dependent NAD(P)H-hydrate dehydratase [4.2.1.136](2|2) (2|1|0)
- 1:   ATP-dependent NAD(P)H-hydrate dehydratase [4.2.1.93](1|1) (1|0|0)
- 1:   Acetylene hydratase [4.2.1.112](0|0) (0|0|0)
- 1:   Acetylenecarboxylate hydratase [4.2.1.27](0|0) (0|0|0)
- 1:   Aconitate hydratase [4.2.1.3](4|4) (4|3|1)
- 1:   Aldos-2-ulose dehydratase [4.2.1.110](0|0) (0|0|0)
- 1:   Altronate dehydratase [4.2.1.7](0|0) (0|0|0)
- 1:   Arabidiol synthase [4.2.1.124](0|0) (0|0|0)
- 1:   Arabinonate dehydratase [4.2.1.5](0|0) (0|0|0)
- 1:   Arogenate dehydratase [4.2.1.91](2|1) (2|1|0)
- 1:   Bile-acid 7-alpha-dehydratase [4.2.1.106](0|0) (0|0|0)
- 1:   Bisanhydrobacterioruberin hydratase [4.2.1.161](0|0) (0|0|0)
- 1:   CDP-glucose 4,6-dehydratase [4.2.1.45](0|0) (0|0|0)
- 1:   Capreomycidine synthase [4.2.1.145](0|0) (0|0|0)
- 1:   Carbonic anhydrase [4.2.1.1](2|2) (2|0|0)
- 1:   Carotenoid 1,2-hydratase [4.2.1.131](1|0) (1|0|0)
- 1:   Chlorophyllide a 3(1)-hydratase [4.2.1.165](0|0) (0|0|0)
- 1:   Chorismate dehydratase [4.2.1.151](1|1) (1|0|0)
- 1:   Cis-l-3-hydroxyproline dehydratase [4.2.1.171](0|0) (0|0|0)
- 1:   Colneleate synthase [4.2.1.121](1|1) (1|0|0)
- 1:   Copal-8-ol diphosphate hydratase [4.2.1.133](2|2) (2|2|1)
- 1:   Crotonobetainyl-CoA hydratase [4.2.1.149](1|1) (1|0|0)
- 1:   Cyanamide hydratase [4.2.1.69](0|0) (0|0|0)
- 1:   Cyanase [4.2.1.104](2|2) (2|1|0)
- 1:   Cyanide hydratase [4.2.1.66](1|0) (1|0|0)
- 1:   Cyclohexa-1,5-dienecarbonyl-CoA hydratase [4.2.1.100](0|0) (0|0|0)
- 1:   Cyclohexyl-isocyanide hydratase [4.2.1.103](0|0) (0|0|0)
- 1:   Cystathionine beta-synthase [4.2.1.22](2|2) (2|1|0)
- 1:   D(-)-tartrate dehydratase [4.2.1.81](0|0) (0|0|0)
- 1:   D-fuconate dehydratase [4.2.1.67](0|0) (0|0|0)
- 1:   D-glutamate cyclase [4.2.1.48](0|0) (0|0|0)
- 1:   D-lactate dehydratase [4.2.1.130](1|1) (1|0|0)
- 1:   Dammarenediol II synthase [4.2.1.125](0|0) (0|0|0)
- 1:   Deleted entry [4.2.1.23](0|0) (0|0|0)
- 1:   Dihydroxy-acid dehydratase [4.2.1.9](2|2) (2|1|0)
- 1:   Dimethylmaleate hydratase [4.2.1.85](0|0) (0|0|0)
- 1:   Ectoine synthase [4.2.1.108](1|0) (1|0|0)
- 1:   Enoyl-CoA hydratase [4.2.1.17](3|3) (3|4|3)
- 1:   Enoyl-CoA hydratase 2 [4.2.1.119](3|3) (3|4|3)
- 1:   Ent-8-alpha-hydroxylabd-13-en-15-yl diphosphate synthase [4.2.1.173](0|0) (0|0|0)
- 1:   Fumarate hydratase [4.2.1.2](2|2) (2|0|0)
- 1:   GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase [4.2.1.168](0|0) (0|0|0)
- 1:   GDP-mannose 4,6-dehydratase [4.2.1.47](1|1) (1|0|0)
- 1:   Galactarate dehydratase [4.2.1.42](0|0) (0|0|0)
- 1:   Galactarate dehydratase (D-threo-forming) [4.2.1.158](0|0) (0|0|0)
- 1:   Galactonate dehydratase [4.2.1.6](2|2) (2|1|0)
- 1:   Glucarate dehydratase [4.2.1.40](2|2) (2|1|0)
- 1:   Gluconate dehydratase [4.2.1.39](2|2) (2|1|0)
- 1:   Gluconate/galactonate dehydratase [4.2.1.140](0|0) (0|0|0)
- 1:   Glycerol dehydratase [4.2.1.30](0|0) (0|0|0)
- 1:   Homoaconitate hydratase [4.2.1.36](2|2) (2|1|0)
- 1:   Hydroperoxide dehydratase [4.2.1.92](1|1) (1|0|0)
- 1:   Hydroperoxy icosatetraenoate dehydratase [4.2.1.152](3|3) (3|1|0)
- 1:   Imidazoleglycerol-phosphate dehydratase [4.2.1.19](2|2) (2|2|1)
- 1:   Isohexenylglutaconyl-CoA hydratase [4.2.1.57](0|0) (0|0|0)
- 1:   Itaconyl-CoA hydratase [4.2.1.56](1|1) (1|0|0)
- 1:   Kievitone hydratase [4.2.1.95](0|0) (0|0|0)
- 1:   L(+)-tartrate dehydratase [4.2.1.32](1|1) (1|0|0)
- 1:   L-arabinonate dehydratase [4.2.1.25](0|0) (0|0|0)
- 1:   L-fuconate dehydratase [4.2.1.68](2|2) (2|1|0)
- 1:   L-galactonate dehydratase [4.2.1.146](0|0) (0|0|0)
- 1:   L-rhamnonate dehydratase [4.2.1.90](2|2) (2|1|0)
- 1:   L-talarate dehydratase [4.2.1.156](0|0) (0|0|0)
- 1:   Lactoyl-CoA dehydratase [4.2.1.54](0|0) (0|0|0)
- 1:   Linalool dehydratase [4.2.1.127](0|0) (0|0|0)
- 1:   Long-chain-enoyl-CoA hydratase [4.2.1.74](0|0) (0|0|0)
- 1:   Lupan-3-beta,20-diol synthase [4.2.1.128](0|0) (0|0|0)
- 1:   Maleate hydratase [4.2.1.31](0|0) (0|0|0)
- 1:   Mannonate dehydratase [4.2.1.8](1|2) (1|0|0)
- 1:   Methanogen homoaconitase [4.2.1.114](0|2) (0|0|0)
- 1:   Methylglutaconyl-CoA hydratase [4.2.1.18](1|1) (1|0|0)
- 1:   Methylthioacryloyl-CoA hydratase [4.2.1.155](0|0) (0|0|0)
- 1:   Methylthioribulose 1-phosphate dehydratase [4.2.1.109](2|2) (2|1|0)
- 1:   Myo-inosose-2 dehydratase [4.2.1.44](1|0) (1|0|0)
- 1:   N-acetylmuramic acid 6-phosphate etherase [4.2.1.126](2|1) (2|1|0)
- 1:   Nitrile hydratase [4.2.1.84](2|2) (2|0|0)
- 1:   Octopamine dehydratase [4.2.1.87](0|0) (0|0|0)
- 1:   Oleate hydratase [4.2.1.53](1|0) (1|0|0)
- 1:   Peregrinol diphosphate synthase [4.2.1.174](0|0) (0|0|0)
- 1:   Phaseollidin hydratase [4.2.1.97](0|0) (0|0|0)
- 1:   Phosphinomethylmalate isomerase [4.2.1.166](0|0) (0|0|0)
- 1:   Phosphogluconate dehydratase [4.2.1.12](2|2) (2|1|0)
- 1:   Phosphopyruvate hydratase [4.2.1.11](2|2) (2|1|0)
- 1:   Porphobilinogen synthase [4.2.1.24](1|1) (1|0|0)
- 1:   Prephenate dehydratase [4.2.1.51](3|3) (3|2|1)
- 1:   Propanediol dehydratase [4.2.1.28](0|0) (0|0|0)
- 1:   Protoaphin-aglucone dehydratase (cyclizing) [4.2.1.73](0|0) (0|0|0)
- 1:   Pseudouridylate synthase [4.2.1.70](1|1) (1|0|0)
- 1:   Pterocarpan synthase [4.2.1.139](0|0) (0|0|0)
- 1:   Pyrazolylalanine synthase [4.2.1.50](0|0) (0|0|0)
- 1:   Scytalone dehydratase [4.2.1.94](1|1) (1|0|0)
- 1:   Short-chain-enoyl-CoA hydratase [4.2.1.150](1|1) (1|0|0)
- 1:   Sporulenol synthase [4.2.1.137](0|0) (0|0|0)
- 1:   Squalene--hopanol cyclase [4.2.1.129](1|1) (1|1|0)
- 1:   Tetracenomycin F2 cyclase [4.2.1.154](0|0) (0|0|0)
- 1:   Tetrahymanol synthase [4.2.1.123](0|0) (0|0|0)
- 1:   Trans-4-hydroxy-L-proline dehydratase [4.2.1.172](0|0) (0|0|0)
- 1:   Trans-L-3-hydroxyproline dehydratase [4.2.1.77](1|1) (1|0|0)
- 1:   Trans-feruloyl-CoA hydratase [4.2.1.101](0|0) (0|0|0)
- 1:   Transferred entry: 2.8.3.21 and 4.2.1.149 [4.2.1.89](0|0) (0|0|0)
- 1:   Transferred entry: 3.3.2.4 [4.2.1.37](0|0) (0|0|0)
- 1:   Transferred entry: 3.3.2.9 and 3.3.2.10 [4.2.1.64](0|0) (0|0|0)
- 1:   Transferred entry: 3.3.2.9 and 3.3.2.10 [4.2.1.63](0|0) (0|0|0)
- 1:   Transferred entry: 4.1.1.78 [4.2.1.72](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.100 [4.2.1.102](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.126 [4.2.1.n1](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.134 [4.2.1.n2](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.22 [4.2.1.21](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.27 [4.2.1.71](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.3 [4.2.1.4](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.59 [4.2.1.58](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.59 [4.2.1.61](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.59 [4.2.1.60](0|0) (0|0|0)
- 1:   Transferred entry: 4.2.1.98 [4.2.1.86](0|0) (0|0|0)
- 1:   Transferred entry: 4.3.1.17 [4.2.1.13](0|0) (0|0|0)
- 1:   Transferred entry: 4.3.1.18 [4.2.1.14](0|0) (0|0|0)
- 1:   Transferred entry: 4.3.1.19 [4.2.1.16](0|0) (0|0|0)
- 1:   Transferred entry: 4.3.1.20 [4.2.1.38](0|0) (0|0|0)
- 1:   Transferred entry: 4.3.1.9 [4.2.1.26](0|0) (0|0|0)
- 1:   Transferred entry: 4.3.3.7 [4.2.1.52](0|0) (0|0|0)
- 1:   Transferred entry: 4.4.1.1 [4.2.1.15](0|0) (0|0|0)
- 1:   Transferred entry: 4.99.1.6 [4.2.1.29](0|0) (0|0|0)
- 1:   Tryptophan synthase [4.2.1.20](2|2) (2|2|0)
- 1:   Tryptophan synthase (indole-salvaging) [4.2.1.122](0|0) (0|0|0)
- 1:   UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) [4.2.1.135](0|0) (0|0|0)
- 1:   UDP-N-acetylglucosamine 4,6-dehydratase (inverting) [4.2.1.115](1|1) (1|0|0)
- 1:   UDP-glucose 4,6-dehydratase [4.2.1.76](1|1) (1|0|0)
- 1:   Urocanate hydratase [4.2.1.49](1|1) (1|0|0)
- 1:   Uroporphyrinogen-III synthase [4.2.1.75](1|1) (1|0|0)
- 1:   Versicolorin B synthase [4.2.1.143](0|0) (0|0|0)
- 1:   Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [4.2.1.134](1|1) (1|0|0)
- 1:   Xylonate dehydratase [4.2.1.82](1|2) (1|1|0)
- 1:   dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase [4.2.1.164](0|0) (0|0|0)
- 1:   dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase [4.2.1.159](0|0) (0|0|0)
- 1:   dTDP-glucose 4,6-dehydratase [4.2.1.46](1|1) (1|0|0)
- 1:   hydratase [4.2.1.107](3|3) (3|3|2)
- 1:   isomerase/dehydratase [4.2.1.160](0|0) (0|0|0)
- 1:   o-succinylbenzoate synthase [4.2.1.113](2|2) (2|1|0)

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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PCD-like0Direct
Ribokinase-like0Direct
Urocanase0Direct
L-aspartase-like0Direct
Enolase N-terminal domain-like0Direct
Aconitase B, N-terminal domain0Direct
ClpP/crotonase0Direct
Carbonic anhydrase0Direct
Indigoidine synthase A-like0Direct
YjeF N-terminal domain-like0Direct
Aconitase iron-sulfur domain0Direct
beta-carbonic anhydrase, cab0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
LeuD/IlvD-like0Direct
FumA C-terminal domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Type II 3-dehydroquinate dehydratase0Direct
AraD/HMP-PK domain-like0Direct
FAH0Direct
Aldolase0Direct
Enolase C-terminal domain-like0Direct
HemD-like0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
Ribulose-phoshate binding barrel0Direct
IlvD/EDD N-terminal domain-like0Direct
SIS domain0Direct
Ribosomal protein S5 domain 2-like0Direct
AttH-like0Direct
Cyanase C-terminal domain0Direct
2-methylcitrate dehydratase PrpD2.574e-16Direct
Xylose isomerase-like0.0000000000000222Direct
Nitrile hydratase alpha chain0.0000000000002983Direct
Electron transport accessory proteins0.0000000001713Direct
HSP20-like chaperones0.00001195Direct
Cytochrome P4500.0001612Direct
RmlC-like cupins0.0005006Direct
SCP-like0.0005081Direct
HAD-like0.001153Inherited
EPT/RTPC-like0.003408Inherited
CBS-domain pair0.005808Inherited
ACT-like0.0119Inherited
FabD/lysophospholipase-like0.01692Inherited
Carbon-nitrogen hydrolase0.01952Inherited
Chorismate mutase II0.03129Inherited
Diaminopimelate epimerase-like0.03487Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.04277Inherited
Aminoacid dehydrogenase-like, N-terminal domain0.06008Inherited
ACP-like0.07629Inherited
NTF2-like0.07629Inherited
Bet v1-like0.1291Inherited
Lipoxigenase0.1607Inherited
UBA-like0.2232Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.4268Inherited
NAD(P)-binding Rossmann-fold domains0.9362Inherited
Terpenoid cyclases/Protein prenyltransferases1Inherited
FAD/NAD(P)-binding domain1Inherited
Class I glutamine amidotransferase-like1Inherited
Periplasmic binding protein-like II1Inherited
Dehydroquinate synthase-like1Inherited
Terpenoid synthases1Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
HCDH C-domain-like0Direct
D-glucarate dehydratase-like0Direct
Cyanase C-terminal domain0Direct
UxuA-like0Direct
IlvD/EDD C-terminal domain-like0Direct
Carbonic anhydrase0Direct
Scytalone dehydratase0Direct
FumA C-terminal domain-like0Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0Direct
beta-Hydroxydecanol thiol ester dehydrase0Direct
FabZ-like0Direct
lvD/EDD N-terminal domain-like0Direct
Cyanase N-terminal domain0Direct
Tryptophan biosynthesis enzymes0Direct
Nitrile hydratase beta chain0Direct
AraD-like aldolase/epimerase0Direct
Class I aldolase0Direct
YjeF C-terminal domain-like0Direct
LeuD-like0Direct
MaoC-like0Direct
AttH-like0Direct
mono-SIS domain0Direct
5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)0Direct
HemD-like0Direct
L-aspartase/fumarase0Direct
Formaldehyde-activating enzyme, FAE0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Type II 3-dehydroquinate dehydratase0Direct
Crotonase-like0Direct
Enolase N-terminal domain-like0Direct
Histidinol phosphatase-like0Direct
PCD-like0Direct
Enolase0Direct
Urocanase0Direct
Indigoidine synthase A-like0Direct
FAH0Direct
beta-carbonic anhydrase, cab0Direct
Shikimate dehydrogenase-like0Direct
Aconitase B, N-terminal domain0Direct
Aconitase iron-sulfur domain0Direct
Imidazole glycerol phosphate dehydratase0Direct
YjeF N-terminal domain-like1.855e-16Direct
Proline racemase1.855e-16Direct
2-methylcitrate dehydratase PrpD5.532e-16Direct
Phenylalanine metabolism regulatory domain0.00000000000001404Direct
Nitrile hydratase alpha chain0.0000000000003908Direct
DJ-1/PfpI0.00000000003913Direct
Co-chaperone p23-like0.000000007525Direct
Acyl-carrier protein (ACP)0.00000003757Direct
Shikimate kinase (AroK)0.0000002151Direct
FabD-like0.000006424Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.00001877Direct
Tyrosine-dependent oxidoreductases0.0003585Direct
Sterol carrier protein, SCP0.0005358Direct
Cytochrome P4500.000778Direct
Enolpyruvate transferase, EPT0.001939Inherited
Animal lipoxigenases0.002226Inherited
Terpene synthases0.00351Inherited
CBS-domain pair0.005858Inherited
Enolase-phosphatase E10.06208Inherited
Dimeric chorismate mutase0.0721Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.07273Inherited
Lipoxigenase N-terminal domain0.2158Inherited
Terpenoid cyclase N-terminal domain1Inherited
Terpenoid cyclase C-terminal domain1Inherited
Thiolase-related1Inherited
Dehydroquinate synthase, DHQS1Inherited
Phosphate binding protein-like1Inherited
Aminoacid dehydrogenase-like, C-terminal domain1Inherited
Decarboxylase1Inherited

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
ClpP/crotonase0Direct
AttH-like0Direct
Ribokinase-like0Direct
Aldolase0Direct
L-aspartase-like0Direct
Aconitase B, N-terminal domain0Direct
beta-carbonic anhydrase, cab0Direct
Aconitase iron-sulfur domain0Direct
IlvD/EDD N-terminal domain-like0Direct
Enolase N-terminal domain-like0Direct
PCD-like0Direct
Enolase C-terminal domain-like0Direct
FumA C-terminal domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
AraD/HMP-PK domain-like0Direct
FAH0Direct
SIS domain0Direct
Cyanase C-terminal domain0Direct
Type II 3-dehydroquinate dehydratase0Direct
HemD-like0Direct
YjeF N-terminal domain-like0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Ribosomal protein S5 domain 2-like0Direct
LeuD/IlvD-like0Direct
Indigoidine synthase A-like0Direct
Carbonic anhydrase0Direct
Ribulose-phoshate binding barrel0Direct
Urocanase0Direct
2-methylcitrate dehydratase PrpD1.78e-16Direct
Xylose isomerase-like0.00000000000001565Direct
Nitrile hydratase alpha chain0.0000000000002125Direct
Electron transport accessory proteins0.0000000001261Direct
HSP20-like chaperones0.000009471Direct
Cytochrome P4500.0001305Direct
RmlC-like cupins0.0004095Direct
SCP-like0.0004158Direct
HAD-like0.0009516Direct
EPT/RTPC-like0.002849Inherited
CBS-domain pair0.004881Inherited
ACT-like0.0101Inherited
FabD/lysophospholipase-like0.01443Inherited
Carbon-nitrogen hydrolase0.01667Inherited
Chorismate mutase II0.02687Inherited
Diaminopimelate epimerase-like0.02996Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.03681Inherited
Aminoacid dehydrogenase-like, N-terminal domain0.05207Inherited
ACP-like0.06628Inherited
NTF2-like0.06628Inherited
Bet v1-like0.113Inherited
Lipoxigenase0.1415Inherited
UBA-like0.1984Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.3878Inherited
NAD(P)-binding Rossmann-fold domains0.8654Inherited
Dehydroquinate synthase-like1Inherited
Terpenoid synthases1Inherited
Periplasmic binding protein-like II1Inherited
Terpenoid cyclases/Protein prenyltransferases1Inherited
Class I glutamine amidotransferase-like1Inherited
FAD/NAD(P)-binding domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53639,56784
  • 53639 - AraD/HMP-PK domain-like
  • 56784 - HAD-like
    		• 0Direct
    52540,51569
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
    		• 0Direct
    54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
    		• 0Direct
    51366,53686
  • 51366 - Ribulose-phoshate binding barrel
  • 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
    		• 0Direct
    48600,53850
  • 48600 - Chorismate mutase II
  • 53850 - Periplasmic binding protein-like II
    		• 0Direct
    52151,51412
  • 52151 - FabD/lysophospholipase-like
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
    		• 0Direct
    74778,52016
  • 74778 - Aconitase B, N-terminal domain
  • 52016 - LeuD/IlvD-like
    		• 0Direct
    55205,52540
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
    		• 0Direct
    51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
    		• 0Direct
    143975,52016
  • 143975 - IlvD/EDD N-terminal domain-like
  • 52016 - LeuD/IlvD-like
    		• 0Direct
    52016,53732
  • 52016 - LeuD/IlvD-like
  • 53732 - Aconitase iron-sulfur domain
    		• 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
    		• 0Direct
    53686,54631
  • 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
  • 54631 - CBS-domain pair
    		• 0Direct
    54211,51366
  • 54211 - Ribosomal protein S5 domain 2-like
  • 51366 - Ribulose-phoshate binding barrel
    		• 0Direct
    56796,55205
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
    		• 0Direct
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
    		• 0Direct
    54637,52151
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 52151 - FabD/lysophospholipase-like
    		• 0Direct
    53697,46934
  • 53697 - SIS domain
  • 46934 - UBA-like
    		• 0Direct
    54826,51604
  • 54826 - Enolase N-terminal domain-like
  • 51604 - Enolase C-terminal domain-like
    		• 0Direct
    47413,55234
  • 47413 - lambda repressor-like DNA-binding domains
  • 55234 - Cyanase C-terminal domain
    		• 0Direct
    54211,54637
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
    		• 0Direct
    54211,54211
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
    		• 0Direct
    53850,55021
  • 53850 - Periplasmic binding protein-like II
  • 55021 - ACT-like
    		• 0Direct
    64153,53613
  • 64153 - YjeF N-terminal domain-like
  • 53613 - Ribokinase-like
    		• 0Direct
    51569,53223
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
    		• 0Direct
    56784,54211
  • 56784 - HAD-like
  • 54211 - Ribosomal protein S5 domain 2-like
    		• 0Direct
    53732,52016
  • 53732 - Aconitase iron-sulfur domain
  • 52016 - LeuD/IlvD-like
    		• 0Direct
    52096,51735
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
    		• 0.000000000001243Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
    		• 0.0000006605Direct
    48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
    		• 0.00000254Direct
    53686,-9
  • 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
  • -9 - PDB
    		• 0.00000254Direct
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0.00002098Direct
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
    		• 0.002393Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0.01065Inherited
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
    		• 0.03681Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
    		• 0.08757Inherited
    48239,48239
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
    		• 1Inherited
    48239,48576
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48576 - Terpenoid synthases
    		• 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,51569,53223
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
    		• 0Direct
    51735,51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
    		• 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
    		• 0Direct
    56784,54211,54211
  • 56784 - HAD-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
    		• 0Direct
    48600,53850,55021
  • 48600 - Chorismate mutase II
  • 53850 - Periplasmic binding protein-like II
  • 55021 - ACT-like
    		• 0Direct
    55205,52540,51569
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
    		• 0Direct
    51569,53223,51735
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0Direct
    54211,54211,54637
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
    		• 0Direct
    54637,54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
    		• 0Direct
    52096,51735,48179
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
    		• 0Direct
    56796,55205,52540
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
    		• 0Direct
    51735,54637,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
    		• 0Direct
    74778,52016,53732
  • 74778 - Aconitase B, N-terminal domain
  • 52016 - LeuD/IlvD-like
  • 53732 - Aconitase iron-sulfur domain
    		• 0Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
    		• 0.000000003777Direct
    48179,48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
    		• 0.00000254Direct
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
    		• 0.00002958Direct
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
    		• 0.001506Inherited
    48239,48239,48576
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48576 - Terpenoid synthases
    		• 1Inherited

    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)
    Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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    © Copyright 2013 The SUPERFAMILY authors and Julian Gough.