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Enzyme Commission (EC): Isomerases
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Pseudouridine synthase | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Precorrin-8X methylmutase CbiC/CobH | 0 | DIRECT |
| PTPA-like | 0 | DIRECT |
| Allene oxide cyclase-like | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | DIRECT |
| FKBP-like | 0 | DIRECT |
| Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
| Triosephosphate isomerase (TIM) | 0 | DIRECT |
| RbsD-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Ribose/Galactose isomerase RpiB/AlsB | 0 | DIRECT |
| Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
| DeoB insert domain-like | 0 | DIRECT |
| Nudix | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
| Chorismate mutase II | 0 | DIRECT |
| YjeF N-terminal domain-like | 0 | DIRECT |
| Chalcone isomerase | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Cyclophilin-like | 0 | DIRECT |
| DNA topoisomerase IV, alpha subunit | 0 | DIRECT |
| ERP29 C domain-like | 0 | DIRECT |
| Trigger factor ribosome-binding domain | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| DNA topoisomerase I domain | 0 | DIRECT |
| DNA breaking-rejoining enzymes | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Tautomerase/MIF | 0 | DIRECT |
| Cobalamin (vitamin B12)-dependent enzymes | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| TPR-like | 0 | DIRECT |
| GyrA/ParC C-terminal domain-like | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Oxygen-evolving enhancer protein 3, | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| FucI/AraA C-terminal domain-like | 0 | DIRECT |
| Aspartate/glutamate racemase | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Dimeric alpha+beta barrel | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| FucI/AraA N-terminal and middle domains | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 2.574e-16 | DIRECT |
| Alpha-L RNA-binding motif | 0.000000000000001269 | DIRECT |
| ClpP/crotonase | 0.00000000000008341 | DIRECT |
| Lipocalins | 0.000000000008603 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001841 | DIRECT |
| Thioredoxin-like | 0.0000000002674 | DIRECT |
| ABC transporter transmembrane region | 0.000000002834 | DIRECT |
| RNA-binding domain, RBD | 0.0000001241 | DIRECT |
| GroEL-intermediate domain like | 0.0000002605 | DIRECT |
| GroEL apical domain-like | 0.00000707 | DIRECT |
| beta-Roll | 0.00009486 | DIRECT |
| MAPEG domain-like | 0.0002585 | DIRECT |
| AraD/HMP-PK domain-like | 0.0004476 | DIRECT |
| ADC synthase | 0.0009781 | DIRECT |
| MIT domain | 0.001162 | INHERITED FROM: Microtubule-severing ATPase || Enzymes altering polypeptide conformation or assembly || Isomerases altering macromolecular conformation |
| Hedgehog/intein (Hint) domain | 0.001608 | INHERITED FROM: Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
| Homing endonucleases | 0.003418 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
| WW domain | 0.005266 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
| Terpenoid synthases | 0.005941 | INHERITED FROM: Intramolecular lyases || Copalyl diphosphate synthase || Lycopene beta-cyclase |
| FumA C-terminal domain-like | 0.007877 | INHERITED FROM: Interconverting keto- and enol-groups || Oxaloacetate tautomerase || Intramolecular oxidoreductases |
| Galactose mutarotase-like | 0.02661 | INHERITED FROM: Aldose 1-epimerase || Acting on carbohydrates and derivatives || Racemases and epimerases || Glucose-6-phosphate 1-epimerase |
| HSP20-like chaperones | 0.05682 | INHERITED FROM: Other intramolecular oxidoreductases || Prostaglandin-E synthase |
| Growth factor receptor domain | 0.08017 | INHERITED FROM: Transposing S-S bonds || Intramolecular oxidoreductases |
| ACP-like | 0.1337 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Acting on amino acids and derivatives || Racemases and epimerases |
| CoA-transferase family III (CaiB/BaiF) | 0.1806 | INHERITED FROM: Alpha-methylacyl-CoA racemase || Racemases and epimerases || Acting on other compounds |
| Di-copper centre-containing domain | 0.2023 | INHERITED FROM: Transposing C=C bonds || L-dopachrome isomerase |
| NTF2-like | 0.249 | INHERITED FROM: Intramolecular lyases || Transposing C=C bonds || Aklanonic acid methyl ester cyclase || Steroid Delta-isomerase |
| Chondroitin AC/alginate lyase | 0.2806 | INHERITED FROM: Chondroitin-glucuronate 5-epimerase || Acting on carbohydrates and derivatives |
| WD40 repeat-like | 0.2962 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3729 | INHERITED FROM: Methylmalonyl-CoA epimerase || Racemases and epimerases || Acting on other compounds |
| Nucleotide-binding domain | 0.4587 | INHERITED FROM: Transferring other groups || UDP-galactopyranose mutase |
| GST C-terminal domain-like | 0.4758 | INHERITED FROM: Maleylacetoacetate isomerase || Other intramolecular oxidoreductases || Cis-trans-isomerases |
| CBS-domain pair | 0.5451 | INHERITED FROM: Arabinose-5-phosphate isomerase |
| Metallo-dependent hydrolases | 0.5691 | INHERITED FROM: Interconverting aldoses and ketoses || Glucuronate isomerase || Intramolecular oxidoreductases |
| FAH | 0.5815 | INHERITED FROM: Transposing C=C bonds || 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| Lipoxigenase | 0.7964 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
| Six-hairpin glycosidases | 0.9237 | INHERITED FROM: N-acylglucosamine 2-epimerase || Acting on carbohydrates and derivatives || Racemases and epimerases || Cellobiose epimerase |
| Ribokinase-like | 1 | INHERITED FROM: Racemases and epimerases || NAD(P)H-hydrate epimerase || Acting on other compounds |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 1 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
| Radical SAM enzymes | 1 | INHERITED FROM: Lysine 2,3-aminomutase |
| EF-hand | 1 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
| L-aspartase-like | 1 | INHERITED FROM: Phenylalanine aminomutase (L-beta-phenylalanine forming) || Tyrosine 2,3-aminomutase || 3-carboxy-cis,cis-muconate cycloisomerase |
| Glycosyl hydrolase domain | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
| Cytochrome P450 | 1 | INHERITED FROM: Other intramolecular oxidoreductases || Prostaglandin-I synthase || Thromboxane-A synthase || Transferring hydroxy groups |
| Enolase N-terminal domain-like | 1 | INHERITED FROM: Intramolecular lyases || L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Muconate cycloisomerase |
| Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: Phosphoenolpyruvate mutase |
| Heme-dependent peroxidases | 1 | INHERITED FROM: 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase || Transferring hydroxy groups |
| HAD-like | 1 | INHERITED FROM: Beta-phosphoglucomutase || Phosphotransferases (phosphomutases) || Phosphomannomutase |
| ACT-like | 1 | INHERITED FROM: Chorismate mutase |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Serine racemase |
| (Trans)glycosidases | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
| RuBisCo, C-terminal domain | 1 | INHERITED FROM: Interconverting keto- and enol-groups || 2,3-diketo-5-methylthiopentyl-1-phosphate enolase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Acting on amino acids and derivatives |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Other intramolecular oxidoreductases || Prolycopene isomerase || Intramolecular lyases || Steroid Delta-isomerase || Lycopene epsilon-cyclase || Lycopene beta-cyclase |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: Mannose-6-phosphate isomerase || UDP-arabinopyranose mutase |
| S13-like H2TH domain | 1 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: UDP-galactopyranose mutase |
| RuBisCO, large subunit, small (N-terminal) domain | 1 | INHERITED FROM: Interconverting keto- and enol-groups || 2,3-diketo-5-methylthiopentyl-1-phosphate enolase |
| Enolase C-terminal domain-like | 1 | INHERITED FROM: Intramolecular lyases || L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Muconate cycloisomerase |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: 7,8-dihydroneopterin epimerase || Acting on other compounds |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) || Acting on carbohydrates and derivatives |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Phosphoribosylanthranilate isomerase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Enzymes altering polypeptide conformation or assembly || Isobutyryl-CoA mutase || Isomerases altering macromolecular conformation |
| Pectin lyase-like | 1 | INHERITED FROM: Mannuronan 5-epimerase || Acting on carbohydrates and derivatives |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-hydroxybutyryl-CoA epimerase || Intramolecular lyases || Transposing C=C bonds || Inositol-3-phosphate synthase || Steroid Delta-isomerase || UDP-glucose 4-epimerase || Acting on carbohydrates and derivatives || UDP-arabinose 4-epimerase || ADP-glyceromanno-heptose 6-epimerase || Delta(3)-Delta(2)-enoyl-CoA isomerase || Racemases and epimerases || Acting on hydroxy acids and derivatives |
| Periplasmic binding protein-like II | 1 | INHERITED FROM: Chorismate mutase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Pseudouridine synthase | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| Precorrin-8X methylmutase CbiC/CobH | 0 | Direct |
| PTPA-like | 0 | Direct |
| Allene oxide cyclase-like | 0 | Direct |
| PUA domain-like | 0 | Direct |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | Direct |
| FKBP-like | 0 | Direct |
| Triger factor/SurA peptide-binding domain-like | 0 | Direct |
| Triosephosphate isomerase (TIM) | 0 | Direct |
| RbsD-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Ribose/Galactose isomerase RpiB/AlsB | 0 | Direct |
| Cobalamin (vitamin B12)-binding domain | 0 | Direct |
| DeoB insert domain-like | 0 | Direct |
| Nudix | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Prokaryotic type I DNA topoisomerase | 0 | Direct |
| Chorismate mutase II | 0 | Direct |
| YjeF N-terminal domain-like | 0 | Direct |
| Chalcone isomerase | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Cyclophilin-like | 0 | Direct |
| DNA topoisomerase IV, alpha subunit | 0 | Direct |
| ERP29 C domain-like | 0 | Direct |
| Trigger factor ribosome-binding domain | 0 | Direct |
| Kelch motif | 0 | Direct |
| DNA topoisomerase I domain | 0 | Direct |
| DNA breaking-rejoining enzymes | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Tautomerase/MIF | 0 | Direct |
| Cobalamin (vitamin B12)-dependent enzymes | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| TPR-like | 0 | Direct |
| GyrA/ParC C-terminal domain-like | 0 | Direct |
| Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Oxygen-evolving enhancer protein 3, | 0 | Direct |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| SIS domain | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| FucI/AraA C-terminal domain-like | 0 | Direct |
| Aspartate/glutamate racemase | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Dimeric alpha+beta barrel | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| FucI/AraA N-terminal and middle domains | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 2.574e-16 | Direct |
| Alpha-L RNA-binding motif | 0.000000000000001269 | Direct |
| ClpP/crotonase | 0.00000000000008341 | Direct |
| Lipocalins | 0.000000000008603 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001841 | Direct |
| Thioredoxin-like | 0.0000000002674 | Direct |
| ABC transporter transmembrane region | 0.000000002834 | Direct |
| RNA-binding domain, RBD | 0.0000001241 | Direct |
| GroEL-intermediate domain like | 0.0000002605 | Direct |
| GroEL apical domain-like | 0.00000707 | Direct |
| beta-Roll | 0.00009486 | Direct |
| MAPEG domain-like | 0.0002585 | Direct |
| AraD/HMP-PK domain-like | 0.0004476 | Direct |
| ADC synthase | 0.0009781 | Direct |
| MIT domain | 0.001162 | Inherited |
| Hedgehog/intein (Hint) domain | 0.001608 | Inherited |
| Homing endonucleases | 0.003418 | Inherited |
| WW domain | 0.005266 | Inherited |
| Terpenoid synthases | 0.005941 | Inherited |
| FumA C-terminal domain-like | 0.007877 | Inherited |
| Galactose mutarotase-like | 0.02661 | Inherited |
| HSP20-like chaperones | 0.05682 | Inherited |
| Growth factor receptor domain | 0.08017 | Inherited |
| ACP-like | 0.1337 | Inherited |
| CoA-transferase family III (CaiB/BaiF) | 0.1806 | Inherited |
| Di-copper centre-containing domain | 0.2023 | Inherited |
| NTF2-like | 0.249 | Inherited |
| Chondroitin AC/alginate lyase | 0.2806 | Inherited |
| WD40 repeat-like | 0.2962 | Inherited |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3729 | Inherited |
| Nucleotide-binding domain | 0.4587 | Inherited |
| GST C-terminal domain-like | 0.4758 | Inherited |
| CBS-domain pair | 0.5451 | Inherited |
| Metallo-dependent hydrolases | 0.5691 | Inherited |
| FAH | 0.5815 | Inherited |
| Lipoxigenase | 0.7964 | Inherited |
| Six-hairpin glycosidases | 0.9237 | Inherited |
| Ribokinase-like | 1 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 1 | Inherited |
| Radical SAM enzymes | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
| L-aspartase-like | 1 | Inherited |
| Glycosyl hydrolase domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Enolase N-terminal domain-like | 1 | Inherited |
| Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
| Heme-dependent peroxidases | 1 | Inherited |
| HAD-like | 1 | Inherited |
| ACT-like | 1 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
| (Trans)glycosidases | 1 | Inherited |
| RuBisCo, C-terminal domain | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| S13-like H2TH domain | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| RuBisCO, large subunit, small (N-terminal) domain | 1 | Inherited |
| Enolase C-terminal domain-like | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Pectin lyase-like | 1 | Inherited |
| Ribosomal protein S5 domain 2-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Periplasmic binding protein-like II | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HCDH C-domain-like | 0 | DIRECT |
| NanE-like | 0 | DIRECT |
| Pseudouridine synthase RsuA/RluD | 0 | DIRECT |
| UDP-galactopyranose mutase, N-terminal domain | 0 | DIRECT |
| Methylmalonyl-CoA epimerase | 0 | DIRECT |
| PA3566-like | 0 | DIRECT |
| Topoisomerase VI-B subunit middle domain | 0 | DIRECT |
| YjeF N-terminal domain-like | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
| Secreted chorismate mutase-like | 0 | DIRECT |
| D-ribulose-5-phosphate 3-epimerase | 0 | DIRECT |
| Tetratricopeptide repeat (TPR) | 0 | DIRECT |
| UDP-galactopyranose mutase | 0 | DIRECT |
| AraA N-terminal and middle domain-like | 0 | DIRECT |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | DIRECT |
| KduI-like | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Xylose isomerase | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | DIRECT |
| Allosteric chorismate mutase | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| Tryptophan biosynthesis enzymes | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| Prokaryotic DNA topoisomerase I, a C-terminal fragment | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| Glutamate mutase, large subunit | 0 | DIRECT |
| Uronate isomerase-like | 0 | DIRECT |
| Pseudouridine synthase RsuA N-terminal domain | 0 | DIRECT |
| Trigger factor ribosome-binding domain | 0 | DIRECT |
| FKBP immunophilin/proline isomerase | 0 | DIRECT |
| Cofactor-dependent phosphoglycerate mutase | 0 | DIRECT |
| Glucose-6-phosphate isomerase, GPI | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| Chalcone isomerase | 0 | DIRECT |
| SnoaL-like polyketide cyclase | 0 | DIRECT |
| Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
| mono-SIS domain | 0 | DIRECT |
| Pseudouridine synthase II TruB | 0 | DIRECT |
| Triosephosphate isomerase (TIM) | 0 | DIRECT |
| AraA C-terminal domain-like | 0 | DIRECT |
| GroEL chaperone, ATPase domain | 0 | DIRECT |
| Muconalactone isomerase, MLI | 0 | DIRECT |
| DNA topoisomerase IV, alpha subunit | 0 | DIRECT |
| D-lysine 5,6-aminomutase alpha subunit, KamD | 0 | DIRECT |
| Diaminopimelate epimerase | 0 | DIRECT |
| GyrA/ParC C-terminal domain-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Tyrosine-dependent oxidoreductases | 0 | DIRECT |
| Phosphoglucose isomerase, PGI | 0 | DIRECT |
| Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
| Type I phosphomannose isomerase | 0 | DIRECT |
| Hypothetical protein YgbM (EC1530) | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Histidine biosynthesis enzymes | 0 | DIRECT |
| Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment | 0 | DIRECT |
| Aspartate/glutamate racemase | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Aldose 1-epimerase (mutarotase) | 0 | DIRECT |
| Ketosteroid isomerase-like | 0 | DIRECT |
| DeoB catalytic domain-like | 0 | DIRECT |
| Proline racemase | 0 | DIRECT |
| PhzC/PhzF-like | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| Hypothetical protein HI1317 | 0 | DIRECT |
| PTPA-like | 0 | DIRECT |
| Precorrin-8X methylmutase CbiC/CobH | 0 | DIRECT |
| dTDP-sugar isomerase | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| Helicase-like "domain" of reverse gyrase | 0 | DIRECT |
| Cyclophilin (peptidylprolyl isomerase) | 0 | DIRECT |
| L-rhamnose isomerase | 0 | DIRECT |
| tRNA pseudouridine synthase TruD | 0 | DIRECT |
| N-acylglucosamine (NAG) epimerase | 0 | DIRECT |
| DeoB insert domain-like | 0 | DIRECT |
| L-fucose isomerase, C-terminal domain | 0 | DIRECT |
| Allene oxide cyclase-like | 0 | DIRECT |
| Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain | 0 | DIRECT |
| Alanine racemase | 0 | DIRECT |
| RbsD-like | 0 | DIRECT |
| IolI-like | 0 | DIRECT |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | DIRECT |
| TF C-terminus | 0 | DIRECT |
| YiiL-like | 0 | DIRECT |
| L-fucose isomerase, N-terminal and second domains | 0 | DIRECT |
| Ribose/Galactose isomerase RpiB/AlsB | 0 | DIRECT |
| Terpene synthases | 0 | DIRECT |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain | 0 | DIRECT |
| Porin chaperone SurA, peptide-binding domain | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, catalytic core | 0 | DIRECT |
| GroEL-like chaperone, intermediate domain | 0 | DIRECT |
| D-ribose-5-phosphate isomerase (RpiA), catalytic domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
| 4-oxalocrotonate tautomerase-like | 0 | DIRECT |
| ERP29 C domain-like | 0 | DIRECT |
| GroEL-like chaperone, apical domain | 0 | DIRECT |
| Pseudouridine synthase I TruA | 0 | DIRECT |
| IPP isomerase-like | 0 | DIRECT |
| Retinol binding protein-like | 0.000000000000001101 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000000000001463 | DIRECT |
| UDP-N-acetylglucosamine 2-epimerase | 0.00000000000001959 | DIRECT |
| YjeF C-terminal domain-like | 0.00000000000003133 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.000000000001131 | DIRECT |
| MIF-related | 0.000000000005814 | DIRECT |
| Dimeric chorismate mutase | 0.00000000005101 | DIRECT |
| Canonical RBD | 0.0000000001247 | DIRECT |
| ABC transporter transmembrane region | 0.00000006149 | DIRECT |
| Predicted hydrolases Cof | 0.000001298 | DIRECT |
| Peptidyl carrier domain | 0.000005087 | DIRECT |
| DHN aldolase/epimerase | 0.00004614 | DIRECT |
| Serralysin-like metalloprotease, C-terminal domain | 0.0001198 | DIRECT |
| mannose-1-phosphate guanylyl transferase | 0.0001467 | DIRECT |
| NRPS condensation domain (amide synthase) | 0.0001913 | DIRECT |
| Terpenoid cyclase N-terminal domain | 0.0006134 | DIRECT |
| AraD-like aldolase/epimerase | 0.0008334 | DIRECT |
| ADC synthase | 0.00157 | INHERITED FROM: Isochorismate synthase || Intramolecular transferases || Transferring hydroxy groups |
| MAPEG domain | 0.001588 | INHERITED FROM: Other intramolecular oxidoreductases || Intramolecular oxidoreductases || Prostaglandin-E synthase |
| Co-chaperone p23-like | 0.002563 | INHERITED FROM: Other intramolecular oxidoreductases || Intramolecular oxidoreductases || Prostaglandin-E synthase |
| Terpenoid cyclase C-terminal domain | 0.00275 | INHERITED FROM: Intramolecular lyases || Copalyl diphosphate synthase || Ent-copalyl diphosphate synthase |
| Intein (protein splicing domain) | 0.002846 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
| TyrA dimerization domain-like | 0.005622 | INHERITED FROM: Transferring other groups || Intramolecular transferases || Chorismate mutase |
| WW domain | 0.0069 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
| FumA C-terminal domain-like | 0.00838 | INHERITED FROM: Interconverting keto- and enol-groups || Oxaloacetate tautomerase || Intramolecular oxidoreductases |
| MIT domain | 0.02131 | INHERITED FROM: Microtubule-severing ATPase || Enzymes altering polypeptide conformation or assembly || Isomerases altering macromolecular conformation |
| WD40-repeat | 0.02409 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
| D-glucarate dehydratase-like | 0.03331 | INHERITED FROM: Intramolecular lyases || L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Muconate cycloisomerase |
| Animal lipoxigenases | 0.07963 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
| Growth factor receptor domain | 0.1241 | INHERITED FROM: Transposing S-S bonds || Intramolecular oxidoreductases |
| CoA-transferase family III (CaiB/BaiF) | 0.1977 | INHERITED FROM: Alpha-methylacyl-CoA racemase || Racemases and epimerases || Acting on other compounds |
| Glutathione S-transferase (GST), N-terminal domain | 0.3154 | INHERITED FROM: Maleylacetoacetate isomerase || Other intramolecular oxidoreductases || Cis-trans-isomerases |
| Phenylalanine metabolism regulatory domain | 0.3641 | INHERITED FROM: Transferring other groups || Chorismate mutase |
| Glutathione S-transferase (GST), C-terminal domain | 0.3785 | INHERITED FROM: Maleylacetoacetate isomerase || Other intramolecular oxidoreductases || Cis-trans-isomerases |
| Squalene synthase | 0.3813 | INHERITED FROM: Intramolecular lyases || Lycopene beta-cyclase |
| Myeloperoxidase-like | 0.4241 | INHERITED FROM: 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase || Transferring hydroxy groups |
| CBS-domain pair | 0.5352 | INHERITED FROM: Arabinose-5-phosphate isomerase |
| FAH | 0.5814 | INHERITED FROM: Transposing C=C bonds || 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| Lipoxigenase N-terminal domain | 0.6124 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
| double-SIS domain | 0.7986 | INHERITED FROM: Glucose-6-phosphate isomerase || Mannose-6-phosphate isomerase || D-glucosamine-6-phosphate 4-epimerase |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0.8769 | INHERITED FROM: Phosphoenolpyruvate mutase |
| beta-Phosphoglucomutase-like | 0.9643 | INHERITED FROM: Beta-phosphoglucomutase |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) |
| HAL/PAL-like | 1 | INHERITED FROM: Phenylalanine aminomutase (L-beta-phenylalanine forming) || Transferring amino groups || Tyrosine 2,3-aminomutase |
| Amylase, catalytic domain | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
| Class I glutamine amidotransferases (GAT) | 1 | INHERITED FROM: Phosphoribosylanthranilate isomerase |
| Phosphate binding protein-like | 1 | INHERITED FROM: Chorismate mutase |
| L-aspartase/fumarase | 1 | INHERITED FROM: Intramolecular lyases || 3-carboxy-cis,cis-muconate cycloisomerase |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Serine racemase |
| Enolase N-terminal domain-like | 1 | INHERITED FROM: Intramolecular lyases || L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Muconate cycloisomerase |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 1 | INHERITED FROM: Interconverting keto- and enol-groups || 2,3-diketo-5-methylthiopentyl-1-phosphate enolase |
| ABC transporter ATPase domain-like | 1 | INHERITED FROM: Channel-conductance-controlling ATPase || Enzymes altering polypeptide conformation or assembly || Isomerases altering macromolecular conformation |
| Dihydrodipicolinate reductase-like | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
| Nitrogenase iron protein-like | 1 | INHERITED FROM: Isobutyryl-CoA mutase |
| Extended AAA-ATPase domain | 1 | INHERITED FROM: Microtubule-severing ATPase || Enzymes altering polypeptide conformation or assembly || Isomerases altering macromolecular conformation |
| Cytochrome P450 | 1 | INHERITED FROM: Other intramolecular oxidoreductases || Thromboxane-A synthase || Transferring hydroxy groups |
| RuBisCo, large subunit, C-terminal domain | 1 | INHERITED FROM: Interconverting keto- and enol-groups || 2,3-diketo-5-methylthiopentyl-1-phosphate enolase |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HCDH C-domain-like | 0 | Direct |
| NanE-like | 0 | Direct |
| Pseudouridine synthase RsuA/RluD | 0 | Direct |
| UDP-galactopyranose mutase, N-terminal domain | 0 | Direct |
| Methylmalonyl-CoA epimerase | 0 | Direct |
| PA3566-like | 0 | Direct |
| Topoisomerase VI-B subunit middle domain | 0 | Direct |
| YjeF N-terminal domain-like | 0 | Direct |
| Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
| Secreted chorismate mutase-like | 0 | Direct |
| D-ribulose-5-phosphate 3-epimerase | 0 | Direct |
| Tetratricopeptide repeat (TPR) | 0 | Direct |
| UDP-galactopyranose mutase | 0 | Direct |
| AraA N-terminal and middle domain-like | 0 | Direct |
| beta-Hydroxydecanol thiol ester dehydrase | 0 | Direct |
| KduI-like | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Xylose isomerase | 0 | Direct |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | Direct |
| Allosteric chorismate mutase | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| Tryptophan biosynthesis enzymes | 0 | Direct |
| Kelch motif | 0 | Direct |
| Prokaryotic DNA topoisomerase I, a C-terminal fragment | 0 | Direct |
| PDI-like | 0 | Direct |
| Glutamate mutase, large subunit | 0 | Direct |
| Uronate isomerase-like | 0 | Direct |
| Pseudouridine synthase RsuA N-terminal domain | 0 | Direct |
| Trigger factor ribosome-binding domain | 0 | Direct |
| FKBP immunophilin/proline isomerase | 0 | Direct |
| Cofactor-dependent phosphoglycerate mutase | 0 | Direct |
| Glucose-6-phosphate isomerase, GPI | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| PUA domain | 0 | Direct |
| Chalcone isomerase | 0 | Direct |
| SnoaL-like polyketide cyclase | 0 | Direct |
| Cobalamin (vitamin B12)-binding domain | 0 | Direct |
| mono-SIS domain | 0 | Direct |
| Pseudouridine synthase II TruB | 0 | Direct |
| Triosephosphate isomerase (TIM) | 0 | Direct |
| AraA C-terminal domain-like | 0 | Direct |
| GroEL chaperone, ATPase domain | 0 | Direct |
| Muconalactone isomerase, MLI | 0 | Direct |
| DNA topoisomerase IV, alpha subunit | 0 | Direct |
| D-lysine 5,6-aminomutase alpha subunit, KamD | 0 | Direct |
| Diaminopimelate epimerase | 0 | Direct |
| GyrA/ParC C-terminal domain-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Tyrosine-dependent oxidoreductases | 0 | Direct |
| Phosphoglucose isomerase, PGI | 0 | Direct |
| Prokaryotic type I DNA topoisomerase | 0 | Direct |
| Type I phosphomannose isomerase | 0 | Direct |
| Hypothetical protein YgbM (EC1530) | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Histidine biosynthesis enzymes | 0 | Direct |
| Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment | 0 | Direct |
| Aspartate/glutamate racemase | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Aldose 1-epimerase (mutarotase) | 0 | Direct |
| Ketosteroid isomerase-like | 0 | Direct |
| DeoB catalytic domain-like | 0 | Direct |
| Proline racemase | 0 | Direct |
| PhzC/PhzF-like | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Crotonase-like | 0 | Direct |
| Hypothetical protein HI1317 | 0 | Direct |
| PTPA-like | 0 | Direct |
| Precorrin-8X methylmutase CbiC/CobH | 0 | Direct |
| dTDP-sugar isomerase | 0 | Direct |
| IF2B-like | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| Helicase-like "domain" of reverse gyrase | 0 | Direct |
| Cyclophilin (peptidylprolyl isomerase) | 0 | Direct |
| L-rhamnose isomerase | 0 | Direct |
| tRNA pseudouridine synthase TruD | 0 | Direct |
| N-acylglucosamine (NAG) epimerase | 0 | Direct |
| DeoB insert domain-like | 0 | Direct |
| L-fucose isomerase, C-terminal domain | 0 | Direct |
| Allene oxide cyclase-like | 0 | Direct |
| Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain | 0 | Direct |
| Alanine racemase | 0 | Direct |
| RbsD-like | 0 | Direct |
| IolI-like | 0 | Direct |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | Direct |
| TF C-terminus | 0 | Direct |
| YiiL-like | 0 | Direct |
| L-fucose isomerase, N-terminal and second domains | 0 | Direct |
| Ribose/Galactose isomerase RpiB/AlsB | 0 | Direct |
| Terpene synthases | 0 | Direct |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain | 0 | Direct |
| Porin chaperone SurA, peptide-binding domain | 0 | Direct |
| Eukaryotic DNA topoisomerase I, catalytic core | 0 | Direct |
| GroEL-like chaperone, intermediate domain | 0 | Direct |
| D-ribose-5-phosphate isomerase (RpiA), catalytic domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
| 4-oxalocrotonate tautomerase-like | 0 | Direct |
| ERP29 C domain-like | 0 | Direct |
| GroEL-like chaperone, apical domain | 0 | Direct |
| Pseudouridine synthase I TruA | 0 | Direct |
| IPP isomerase-like | 0 | Direct |
| Retinol binding protein-like | 0.000000000000001101 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.000000000000001463 | Direct |
| UDP-N-acetylglucosamine 2-epimerase | 0.00000000000001959 | Direct |
| YjeF C-terminal domain-like | 0.00000000000003133 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.000000000001131 | Direct |
| MIF-related | 0.000000000005814 | Direct |
| Dimeric chorismate mutase | 0.00000000005101 | Direct |
| Canonical RBD | 0.0000000001247 | Direct |
| ABC transporter transmembrane region | 0.00000006149 | Direct |
| Predicted hydrolases Cof | 0.000001298 | Direct |
| Peptidyl carrier domain | 0.000005087 | Direct |
| DHN aldolase/epimerase | 0.00004614 | Direct |
| Serralysin-like metalloprotease, C-terminal domain | 0.0001198 | Direct |
| mannose-1-phosphate guanylyl transferase | 0.0001467 | Direct |
| NRPS condensation domain (amide synthase) | 0.0001913 | Direct |
| Terpenoid cyclase N-terminal domain | 0.0006134 | Direct |
| AraD-like aldolase/epimerase | 0.0008334 | Direct |
| ADC synthase | 0.00157 | Inherited |
| MAPEG domain | 0.001588 | Inherited |
| Co-chaperone p23-like | 0.002563 | Inherited |
| Terpenoid cyclase C-terminal domain | 0.00275 | Inherited |
| Intein (protein splicing domain) | 0.002846 | Inherited |
| TyrA dimerization domain-like | 0.005622 | Inherited |
| WW domain | 0.0069 | Inherited |
| FumA C-terminal domain-like | 0.00838 | Inherited |
| MIT domain | 0.02131 | Inherited |
| WD40-repeat | 0.02409 | Inherited |
| D-glucarate dehydratase-like | 0.03331 | Inherited |
| Animal lipoxigenases | 0.07963 | Inherited |
| Growth factor receptor domain | 0.1241 | Inherited |
| CoA-transferase family III (CaiB/BaiF) | 0.1977 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.3154 | Inherited |
| Phenylalanine metabolism regulatory domain | 0.3641 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.3785 | Inherited |
| Squalene synthase | 0.3813 | Inherited |
| Myeloperoxidase-like | 0.4241 | Inherited |
| CBS-domain pair | 0.5352 | Inherited |
| FAH | 0.5814 | Inherited |
| Lipoxigenase N-terminal domain | 0.6124 | Inherited |
| double-SIS domain | 0.7986 | Inherited |
| Phosphoenolpyruvate mutase/Isocitrate lyase-like | 0.8769 | Inherited |
| beta-Phosphoglucomutase-like | 0.9643 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| HAL/PAL-like | 1 | Inherited |
| Amylase, catalytic domain | 1 | Inherited |
| Class I glutamine amidotransferases (GAT) | 1 | Inherited |
| Phosphate binding protein-like | 1 | Inherited |
| L-aspartase/fumarase | 1 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
| Enolase N-terminal domain-like | 1 | Inherited |
| Ribulose 1,5-bisphosphate carboxylase-oxygenase | 1 | Inherited |
| ABC transporter ATPase domain-like | 1 | Inherited |
| Dihydrodipicolinate reductase-like | 1 | Inherited |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1 | Inherited |
| Nitrogenase iron protein-like | 1 | Inherited |
| Extended AAA-ATPase domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| RuBisCo, large subunit, C-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| RmlC-like cupins | 0 | DIRECT |
| FKBP-like | 0 | DIRECT |
| Ribose/Galactose isomerase RpiB/AlsB | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| Tautomerase/MIF | 0 | DIRECT |
| Cyclophilin-like | 0 | DIRECT |
| Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| Allene oxide cyclase-like | 0 | DIRECT |
| RbsD-like | 0 | DIRECT |
| FucI/AraA N-terminal and middle domains | 0 | DIRECT |
| Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
| Aspartate/glutamate racemase | 0 | DIRECT |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| Chorismate mutase II | 0 | DIRECT |
| Dimeric alpha+beta barrel | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| PTPA-like | 0 | DIRECT |
| Precorrin-8X methylmutase CbiC/CobH | 0 | DIRECT |
| TPR-like | 0 | DIRECT |
| Chalcone isomerase | 0 | DIRECT |
| Triosephosphate isomerase (TIM) | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Nudix | 0 | DIRECT |
| FucI/AraA C-terminal domain-like | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
| Trigger factor ribosome-binding domain | 0 | DIRECT |
| Cobalamin (vitamin B12)-dependent enzymes | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| DNA topoisomerase IV, alpha subunit | 0 | DIRECT |
| YjeF N-terminal domain-like | 0 | DIRECT |
| Oxygen-evolving enhancer protein 3, | 0 | DIRECT |
| DNA topoisomerase I domain | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | DIRECT |
| GyrA/ParC C-terminal domain-like | 0 | DIRECT |
| Pseudouridine synthase | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| ERP29 C domain-like | 0 | DIRECT |
| DeoB insert domain-like | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| DNA breaking-rejoining enzymes | 0 | DIRECT |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 1.78e-16 | DIRECT |
| Alpha-L RNA-binding motif | 8.835e-16 | DIRECT |
| ClpP/crotonase | 0.00000000000005909 | DIRECT |
| Lipocalins | 0.000000000006216 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001336 | DIRECT |
| Thioredoxin-like | 0.0000000001976 | DIRECT |
| ABC transporter transmembrane region | 0.000000002123 | DIRECT |
| RNA-binding domain, RBD | 0.00000009504 | DIRECT |
| GroEL-intermediate domain like | 0.0000002006 | DIRECT |
| GroEL apical domain-like | 0.000005569 | DIRECT |
| beta-Roll | 0.00007643 | DIRECT |
| MAPEG domain-like | 0.0002101 | DIRECT |
| AraD/HMP-PK domain-like | 0.0003657 | DIRECT |
| ADC synthase | 0.0008062 | DIRECT |
| MIT domain | 0.0009596 | DIRECT |
| Hedgehog/intein (Hint) domain | 0.001333 | INHERITED FROM: Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
| Homing endonucleases | 0.002857 | INHERITED FROM: Enzymes altering nucleic acid conformation || DNA topoisomerase (ATP-hydrolyzing) || Isomerases altering macromolecular conformation |
| WW domain | 0.00442 | INHERITED FROM: Peptidylprolyl isomerase || Cis-trans-isomerases |
| Terpenoid synthases | 0.004997 | INHERITED FROM: Lycopene beta-cyclase || Copalyl diphosphate synthase || Intramolecular lyases |
| FumA C-terminal domain-like | 0.006648 | INHERITED FROM: Oxaloacetate tautomerase || Interconverting keto- and enol-groups || Intramolecular oxidoreductases |
| Galactose mutarotase-like | 0.0228 | INHERITED FROM: Glucose-6-phosphate 1-epimerase || Racemases and epimerases || Aldose 1-epimerase || Acting on carbohydrates and derivatives |
| HSP20-like chaperones | 0.0492 | INHERITED FROM: Prostaglandin-E synthase || Other intramolecular oxidoreductases |
| Growth factor receptor domain | 0.06971 | INHERITED FROM: Transposing S-S bonds || Intramolecular oxidoreductases |
| ACP-like | 0.1172 | INHERITED FROM: Acting on amino acids and derivatives || Phenylalanine racemase (ATP-hydrolyzing) || Racemases and epimerases |
| CoA-transferase family III (CaiB/BaiF) | 0.1596 | INHERITED FROM: Acting on other compounds || Alpha-methylacyl-CoA racemase || Racemases and epimerases |
| Di-copper centre-containing domain | 0.1793 | INHERITED FROM: Transposing C=C bonds || L-dopachrome isomerase |
| NTF2-like | 0.2222 | INHERITED FROM: Transposing C=C bonds || Steroid Delta-isomerase || Aklanonic acid methyl ester cyclase || Intramolecular lyases |
| Chondroitin AC/alginate lyase | 0.2524 | INHERITED FROM: Chondroitin-glucuronate 5-epimerase || Racemases and epimerases || Acting on carbohydrates and derivatives |
| WD40 repeat-like | 0.2671 | INHERITED FROM: Peptidylprolyl isomerase || Cis-trans-isomerases |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3376 | INHERITED FROM: Methylmalonyl-CoA epimerase || Acting on other compounds || Racemases and epimerases |
| Nucleotide-binding domain | 0.4178 | INHERITED FROM: UDP-galactopyranose mutase || Transferring other groups |
| GST C-terminal domain-like | 0.4338 | INHERITED FROM: Maleylacetoacetate isomerase || Cis-trans-isomerases || Other intramolecular oxidoreductases |
| CBS-domain pair | 0.4991 | INHERITED FROM: Arabinose-5-phosphate isomerase |
| Metallo-dependent hydrolases | 0.5217 | INHERITED FROM: Interconverting aldoses and ketoses || Intramolecular oxidoreductases || Glucuronate isomerase |
| FAH | 0.5335 | INHERITED FROM: Transposing C=C bonds || 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| Lipoxigenase | 0.733 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
| Six-hairpin glycosidases | 0.8534 | INHERITED FROM: N-acylglucosamine 2-epimerase || Cellobiose epimerase || Racemases and epimerases || Acting on carbohydrates and derivatives |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.9729 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) || Acting on carbohydrates and derivatives |
| Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: Phosphoenolpyruvate mutase |
| Cytochrome P450 | 1 | INHERITED FROM: Transferring hydroxy groups || Thromboxane-A synthase || Other intramolecular oxidoreductases || Prostaglandin-I synthase |
| Ribokinase-like | 1 | INHERITED FROM: Acting on other compounds || NAD(P)H-hydrate epimerase || Racemases and epimerases |
| Glycosyl hydrolase domain | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
| EF-hand | 1 | INHERITED FROM: Peptidylprolyl isomerase || Cis-trans-isomerases |
| Radical SAM enzymes | 1 | INHERITED FROM: Lysine 2,3-aminomutase |
| L-aspartase-like | 1 | INHERITED FROM: Phenylalanine aminomutase (L-beta-phenylalanine forming) || Tyrosine 2,3-aminomutase || 3-carboxy-cis,cis-muconate cycloisomerase |
| Pectin lyase-like | 1 | INHERITED FROM: Mannuronan 5-epimerase || Acting on carbohydrates and derivatives |
| Enolase N-terminal domain-like | 1 | INHERITED FROM: L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Intramolecular lyases || Muconate cycloisomerase |
| Periplasmic binding protein-like II | 1 | INHERITED FROM: Chorismate mutase |
| Enolase C-terminal domain-like | 1 | INHERITED FROM: L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Intramolecular lyases || Muconate cycloisomerase |
| RuBisCO, large subunit, small (N-terminal) domain | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol-groups |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: UDP-arabinose 4-epimerase || Transposing C=C bonds || Steroid Delta-isomerase || 3-hydroxybutyryl-CoA epimerase || ADP-glyceromanno-heptose 6-epimerase || Intramolecular lyases || Delta(3)-Delta(2)-enoyl-CoA isomerase || Racemases and epimerases || Acting on hydroxy acids and derivatives || UDP-glucose 4-epimerase || Acting on carbohydrates and derivatives || Inositol-3-phosphate synthase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Enzymes altering polypeptide conformation or assembly || Isobutyryl-CoA mutase || Isomerases altering macromolecular conformation |
| Heme-dependent peroxidases | 1 | INHERITED FROM: Transferring hydroxy groups || 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase |
| RuBisCo, C-terminal domain | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol-groups |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: UDP-arabinopyranose mutase || Mannose-6-phosphate isomerase |
| S13-like H2TH domain | 1 | INHERITED FROM: Enzymes altering nucleic acid conformation || DNA topoisomerase (ATP-hydrolyzing) || Isomerases altering macromolecular conformation |
| (Trans)glycosidases | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Serine racemase |
| HAD-like | 1 | INHERITED FROM: Phosphotransferases (phosphomutases) || Beta-phosphoglucomutase || Phosphomannomutase |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Enzymes altering nucleic acid conformation || DNA topoisomerase (ATP-hydrolyzing) || Isomerases altering macromolecular conformation |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | INHERITED FROM: Acting on other compounds || 7,8-dihydroneopterin epimerase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: Acting on amino acids and derivatives || Phenylalanine racemase (ATP-hydrolyzing) |
| FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: UDP-galactopyranose mutase |
| Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Phosphoribosylanthranilate isomerase |
| Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Steroid Delta-isomerase || Prolycopene isomerase || Lycopene beta-cyclase || Lycopene epsilon-cyclase || Intramolecular lyases || Other intramolecular oxidoreductases |
| ACT-like | 1 | INHERITED FROM: Chorismate mutase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| RmlC-like cupins | 0 | Direct |
| FKBP-like | 0 | Direct |
| Ribose/Galactose isomerase RpiB/AlsB | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| Tautomerase/MIF | 0 | Direct |
| Cyclophilin-like | 0 | Direct |
| Prokaryotic type I DNA topoisomerase | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| Allene oxide cyclase-like | 0 | Direct |
| RbsD-like | 0 | Direct |
| FucI/AraA N-terminal and middle domains | 0 | Direct |
| Triger factor/SurA peptide-binding domain-like | 0 | Direct |
| Aspartate/glutamate racemase | 0 | Direct |
| D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Kelch motif | 0 | Direct |
| Chorismate mutase II | 0 | Direct |
| Dimeric alpha+beta barrel | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| PTPA-like | 0 | Direct |
| Precorrin-8X methylmutase CbiC/CobH | 0 | Direct |
| TPR-like | 0 | Direct |
| Chalcone isomerase | 0 | Direct |
| Triosephosphate isomerase (TIM) | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| SIS domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Nudix | 0 | Direct |
| FucI/AraA C-terminal domain-like | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
| Trigger factor ribosome-binding domain | 0 | Direct |
| Cobalamin (vitamin B12)-dependent enzymes | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| DNA topoisomerase IV, alpha subunit | 0 | Direct |
| YjeF N-terminal domain-like | 0 | Direct |
| Oxygen-evolving enhancer protein 3, | 0 | Direct |
| DNA topoisomerase I domain | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | Direct |
| GyrA/ParC C-terminal domain-like | 0 | Direct |
| Pseudouridine synthase | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| ERP29 C domain-like | 0 | Direct |
| DeoB insert domain-like | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| Cobalamin (vitamin B12)-binding domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| DNA breaking-rejoining enzymes | 0 | Direct |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 1.78e-16 | Direct |
| Alpha-L RNA-binding motif | 8.835e-16 | Direct |
| ClpP/crotonase | 0.00000000000005909 | Direct |
| Lipocalins | 0.000000000006216 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001336 | Direct |
| Thioredoxin-like | 0.0000000001976 | Direct |
| ABC transporter transmembrane region | 0.000000002123 | Direct |
| RNA-binding domain, RBD | 0.00000009504 | Direct |
| GroEL-intermediate domain like | 0.0000002006 | Direct |
| GroEL apical domain-like | 0.000005569 | Direct |
| beta-Roll | 0.00007643 | Direct |
| MAPEG domain-like | 0.0002101 | Direct |
| AraD/HMP-PK domain-like | 0.0003657 | Direct |
| ADC synthase | 0.0008062 | Direct |
| MIT domain | 0.0009596 | Direct |
| Hedgehog/intein (Hint) domain | 0.001333 | Inherited |
| Homing endonucleases | 0.002857 | Inherited |
| WW domain | 0.00442 | Inherited |
| Terpenoid synthases | 0.004997 | Inherited |
| FumA C-terminal domain-like | 0.006648 | Inherited |
| Galactose mutarotase-like | 0.0228 | Inherited |
| HSP20-like chaperones | 0.0492 | Inherited |
| Growth factor receptor domain | 0.06971 | Inherited |
| ACP-like | 0.1172 | Inherited |
| CoA-transferase family III (CaiB/BaiF) | 0.1596 | Inherited |
| Di-copper centre-containing domain | 0.1793 | Inherited |
| NTF2-like | 0.2222 | Inherited |
| Chondroitin AC/alginate lyase | 0.2524 | Inherited |
| WD40 repeat-like | 0.2671 | Inherited |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.3376 | Inherited |
| Nucleotide-binding domain | 0.4178 | Inherited |
| GST C-terminal domain-like | 0.4338 | Inherited |
| CBS-domain pair | 0.4991 | Inherited |
| Metallo-dependent hydrolases | 0.5217 | Inherited |
| FAH | 0.5335 | Inherited |
| Lipoxigenase | 0.733 | Inherited |
| Six-hairpin glycosidases | 0.8534 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.9729 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
| Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| Ribokinase-like | 1 | Inherited |
| Glycosyl hydrolase domain | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Radical SAM enzymes | 1 | Inherited |
| L-aspartase-like | 1 | Inherited |
| Pectin lyase-like | 1 | Inherited |
| Enolase N-terminal domain-like | 1 | Inherited |
| Periplasmic binding protein-like II | 1 | Inherited |
| Enolase C-terminal domain-like | 1 | Inherited |
| RuBisCO, large subunit, small (N-terminal) domain | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Heme-dependent peroxidases | 1 | Inherited |
| RuBisCo, C-terminal domain | 1 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| S13-like H2TH domain | 1 | Inherited |
| (Trans)glycosidases | 1 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
| HAD-like | 1 | Inherited |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Ribosomal protein S5 domain 2-like | 1 | Inherited |
| Tetrahydrobiopterin biosynthesis enzymes-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| FAD-linked reductases, C-terminal domain | 1 | Inherited |
| Class I glutamine amidotransferase-like | 1 | Inherited |
| Acetyl-CoA synthetase-like | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
| ACT-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
64158,53649
64158 - 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
56719,56719
56719 - Type II DNA topoisomerase
56719 - Type II DNA topoisomerase | 0 | DIRECT |
55608,56712
55608 - Homing endonucleases
56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
51294,56719
51294 - Hedgehog/intein (Hint) domain
56719 - Type II DNA topoisomerase | 0 | DIRECT |
56712,57783
56712 - Prokaryotic type I DNA topoisomerase
57783 - Zinc beta-ribbon | 0 | DIRECT |
109998,54534
109998 - Triger factor/SurA peptide-binding domain-like
54534 - FKBP-like | 0 | DIRECT |
56719,55608
56719 - Type II DNA topoisomerase
55608 - Homing endonucleases | 0 | DIRECT |
143856,53649
143856 - DeoB insert domain-like
53649 - Alkaline phosphatase-like | 0 | DIRECT |
55869,56349
55869 - DNA topoisomerase I domain
56349 - DNA breaking-rejoining enzymes | 0 | DIRECT |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
52242,52540
52242 - Cobalamin (vitamin B12)-binding domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
100950,75445
100950 - NagB/RpiA/CoA transferase-like
75445 - D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
54534,109998
54534 - FKBP-like
109998 - Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
102735,54534
102735 - Trigger factor ribosome-binding domain
54534 - FKBP-like | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
55874,56719
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
56719 - Type II DNA topoisomerase | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51045,54534
51045 - WW domain
54534 - FKBP-like | 0 | DIRECT |
56719,101904
56719 - Type II DNA topoisomerase
101904 - GyrA/ParC C-terminal domain-like | 0 | DIRECT |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
50891,48452
50891 - Cyclophilin-like
48452 - TPR-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | DIRECT |
56529,56529
56529 - FAH
56529 - FAH | 0 | DIRECT |
51735,74650
51735 - NAD(P)-binding Rossmann-fold domains
74650 - Galactose mutarotase-like | 0 | DIRECT |
52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
53743,50443
53743 - FucI/AraA N-terminal and middle domains
50443 - FucI/AraA C-terminal domain-like | 0 | DIRECT |
54506,54506
54506 - Diaminopimelate epimerase-like
54506 - Diaminopimelate epimerase-like | 0 | DIRECT |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
55120,88697
55120 - Pseudouridine synthase
88697 - PUA domain-like | 0 | DIRECT |
54534,47473
54534 - FKBP-like
47473 - EF-hand | 0 | DIRECT |
53697,54631
53697 - SIS domain
54631 - CBS-domain pair | 0 | DIRECT |
56741,56349
56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
56349 - DNA breaking-rejoining enzymes | 0 | DIRECT |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0 | DIRECT |
54928,50891
54928 - RNA-binding domain, RBD
50891 - Cyclophilin-like | 0 | DIRECT |
55174,55120
55174 - Alpha-L RNA-binding motif
55120 - Pseudouridine synthase | 0 | DIRECT |
64153,53613
64153 - YjeF N-terminal domain-like
53613 - Ribokinase-like | 0 | DIRECT |
55874,46946
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
46946 - S13-like H2TH domain | 0 | DIRECT |
52833,47933
52833 - Thioredoxin-like
47933 - ERP29 C domain-like | 0 | DIRECT |
51126,51120
51126 - Pectin lyase-like
51120 - beta-Roll | 0 | DIRECT |
56712,51294
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
54211,56719
54211 - Ribosomal protein S5 domain 2-like
56719 - Type II DNA topoisomerase | 0 | DIRECT |
57783,57783
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
51703,52242
51703 - Cobalamin (vitamin B12)-dependent enzymes
52242 - Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
47027,52096
47027 - Acyl-CoA binding protein
52096 - ClpP/crotonase | 0 | DIRECT |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53681,53681
53681 - Aspartate/glutamate racemase
53681 - Aspartate/glutamate racemase | 0 | DIRECT |
46946,54211
46946 - S13-like H2TH domain
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
56349,46596
56349 - DNA breaking-rejoining enzymes
46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
55608,56719
55608 - Homing endonucleases
56719 - Type II DNA topoisomerase | 0 | DIRECT |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0.000000000003135 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001048 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000001853 | DIRECT |
51120,51120
51120 - beta-Roll
51120 - beta-Roll | 0.00000004799 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.0000002006 | DIRECT |
56801,47336
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.000003144 | DIRECT |
47336,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.000005569 | DIRECT |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.00002211 | DIRECT |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0.00004875 | DIRECT |
53448,51182
53448 - Nucleotide-diphospho-sugar transferases
51182 - RmlC-like cupins | 0.00009779 | DIRECT |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0.0002698 | DIRECT |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.002324 | INHERITED FROM: Acting on amino acids and derivatives || Racemases and epimerases |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.006279 | INHERITED FROM: UDP-galactopyranose mutase || Transferring other groups || Intramolecular transferases |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.08053 | INHERITED FROM: Acting on amino acids and derivatives || Phenylalanine racemase (ATP-hydrolyzing) || Racemases and epimerases |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.3265 | INHERITED FROM: Maleylacetoacetate isomerase || Cis-trans-isomerases || Other intramolecular oxidoreductases |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.6061 | INHERITED FROM: Hydroperoxy icosatetraenoate isomerase || Transferring hydroxy groups |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Enzymes altering nucleic acid conformation || Isomerases altering macromolecular conformation |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 1 | INHERITED FROM: L-Ala-D/L-Glu epimerase || Chloromuconate cycloisomerase || Intramolecular lyases || Muconate cycloisomerase |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol-groups |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
64158,53649
64158 - 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
53649 - Alkaline phosphatase-like | 0 | Direct |
56719,56719
56719 - Type II DNA topoisomerase
56719 - Type II DNA topoisomerase | 0 | Direct |
55608,56712
55608 - Homing endonucleases
56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
51294,56719
51294 - Hedgehog/intein (Hint) domain
56719 - Type II DNA topoisomerase | 0 | Direct |
56712,57783
56712 - Prokaryotic type I DNA topoisomerase
57783 - Zinc beta-ribbon | 0 | Direct |
109998,54534
109998 - Triger factor/SurA peptide-binding domain-like
54534 - FKBP-like | 0 | Direct |
56719,55608
56719 - Type II DNA topoisomerase
55608 - Homing endonucleases | 0 | Direct |
143856,53649
143856 - DeoB insert domain-like
53649 - Alkaline phosphatase-like | 0 | Direct |
55869,56349
55869 - DNA topoisomerase I domain
56349 - DNA breaking-rejoining enzymes | 0 | Direct |
48600,53850
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
51366,51366
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
52242,52540
52242 - Cobalamin (vitamin B12)-binding domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
100950,75445
100950 - NagB/RpiA/CoA transferase-like
75445 - D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
54534,109998
54534 - FKBP-like
109998 - Triger factor/SurA peptide-binding domain-like | 0 | Direct |
102735,54534
102735 - Trigger factor ribosome-binding domain
54534 - FKBP-like | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
55874,56719
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
56719 - Type II DNA topoisomerase | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51045,54534
51045 - WW domain
54534 - FKBP-like | 0 | Direct |
56719,101904
56719 - Type II DNA topoisomerase
101904 - GyrA/ParC C-terminal domain-like | 0 | Direct |
48239,48239
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
50891,48452
50891 - Cyclophilin-like
48452 - TPR-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | Direct |
56529,56529
56529 - FAH
56529 - FAH | 0 | Direct |
51735,74650
51735 - NAD(P)-binding Rossmann-fold domains
74650 - Galactose mutarotase-like | 0 | Direct |
52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
53743,50443
53743 - FucI/AraA N-terminal and middle domains
50443 - FucI/AraA C-terminal domain-like | 0 | Direct |
54506,54506
54506 - Diaminopimelate epimerase-like
54506 - Diaminopimelate epimerase-like | 0 | Direct |
48600,51735
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
55120,88697
55120 - Pseudouridine synthase
88697 - PUA domain-like | 0 | Direct |
54534,47473
54534 - FKBP-like
47473 - EF-hand | 0 | Direct |
53697,54631
53697 - SIS domain
54631 - CBS-domain pair | 0 | Direct |
56741,56349
56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
56349 - DNA breaking-rejoining enzymes | 0 | Direct |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0 | Direct |
54928,50891
54928 - RNA-binding domain, RBD
50891 - Cyclophilin-like | 0 | Direct |
55174,55120
55174 - Alpha-L RNA-binding motif
55120 - Pseudouridine synthase | 0 | Direct |
64153,53613
64153 - YjeF N-terminal domain-like
53613 - Ribokinase-like | 0 | Direct |
55874,46946
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
46946 - S13-like H2TH domain | 0 | Direct |
52833,47933
52833 - Thioredoxin-like
47933 - ERP29 C domain-like | 0 | Direct |
51126,51120
51126 - Pectin lyase-like
51120 - beta-Roll | 0 | Direct |
56712,51294
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
54211,56719
54211 - Ribosomal protein S5 domain 2-like
56719 - Type II DNA topoisomerase | 0 | Direct |
57783,57783
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
51703,52242
51703 - Cobalamin (vitamin B12)-dependent enzymes
52242 - Cobalamin (vitamin B12)-binding domain | 0 | Direct |
47027,52096
47027 - Acyl-CoA binding protein
52096 - ClpP/crotonase | 0 | Direct |
52096,51735
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53681,53681
53681 - Aspartate/glutamate racemase
53681 - Aspartate/glutamate racemase | 0 | Direct |
46946,54211
46946 - S13-like H2TH domain
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
56349,46596
56349 - DNA breaking-rejoining enzymes
46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
55608,56719
55608 - Homing endonucleases
56719 - Type II DNA topoisomerase | 0 | Direct |
52317,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel | 0.000000000003135 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001048 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000001853 | Direct |
51120,51120
51120 - beta-Roll
51120 - beta-Roll | 0.00000004799 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.0000002006 | Direct |
56801,47336
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.000003144 | Direct |
47336,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.000005569 | Direct |
48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.00002211 | Direct |
53850,55021
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0.00004875 | Direct |
53448,51182
53448 - Nucleotide-diphospho-sugar transferases
51182 - RmlC-like cupins | 0.00009779 | Direct |
48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0.0002698 | Direct |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.002324 | Inherited |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.006279 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.08053 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.3265 | Inherited |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0.6061 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 1 | Inherited |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 1 | Inherited |
54966,51649
54966 - RuBisCO, large subunit, small (N-terminal) domain
51649 - RuBisCo, C-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57783,57783,57783
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | DIRECT |
54534,54534,48452
54534 - FKBP-like
54534 - FKBP-like
48452 - TPR-like | 0 | DIRECT |
102735,54534,109998
102735 - Trigger factor ribosome-binding domain
54534 - FKBP-like
109998 - Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
55874,46946,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
46946 - S13-like H2TH domain
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
55874,54211,56719
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like
56719 - Type II DNA topoisomerase | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
51294,56719,55608
51294 - Hedgehog/intein (Hint) domain
56719 - Type II DNA topoisomerase
55608 - Homing endonucleases | 0 | DIRECT |
54534,54534,54534
54534 - FKBP-like
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
56712,57783,57783
56712 - Prokaryotic type I DNA topoisomerase
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon | 0 | DIRECT |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52540,56712,51294
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
56741,56349,46596
56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
56349 - DNA breaking-rejoining enzymes
46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
52833,52833,47933
52833 - Thioredoxin-like
52833 - Thioredoxin-like
47933 - ERP29 C domain-like | 0 | DIRECT |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0 | DIRECT |
54534,54534,47473
54534 - FKBP-like
54534 - FKBP-like
47473 - EF-hand | 0 | DIRECT |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52540,52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
56719,55608,56719
56719 - Type II DNA topoisomerase
55608 - Homing endonucleases
56719 - Type II DNA topoisomerase | 0 | DIRECT |
109998,54534,54534
109998 - Triger factor/SurA peptide-binding domain-like
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
51126,51120,51120
51126 - Pectin lyase-like
51120 - beta-Roll
51120 - beta-Roll | 0 | DIRECT |
51120,51120,51120
51120 - beta-Roll
51120 - beta-Roll
51120 - beta-Roll | 0.00000004799 | DIRECT |
56801,47336,52777
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.0000001582 | DIRECT |
47336,52777,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.000005569 | DIRECT |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.00002211 | DIRECT |
52777,52777,56801
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.0001405 | DIRECT |
52777,56801,47336
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.0002639 | DIRECT |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57783,57783,57783
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
48239,48239,48576
48239 - Terpenoid cyclases/Protein prenyltransferases
48239 - Terpenoid cyclases/Protein prenyltransferases
48576 - Terpenoid synthases | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48600,53850,55021
48600 - Chorismate mutase II
53850 - Periplasmic binding protein-like II
55021 - ACT-like | 0 | Direct |
54534,54534,48452
54534 - FKBP-like
54534 - FKBP-like
48452 - TPR-like | 0 | Direct |
102735,54534,109998
102735 - Trigger factor ribosome-binding domain
54534 - FKBP-like
109998 - Triger factor/SurA peptide-binding domain-like | 0 | Direct |
55874,46946,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
46946 - S13-like H2TH domain
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
52317,51366,51366
52317 - Class I glutamine amidotransferase-like
51366 - Ribulose-phoshate binding barrel
51366 - Ribulose-phoshate binding barrel | 0 | Direct |
55874,54211,56719
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like
56719 - Type II DNA topoisomerase | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
51294,56719,55608
51294 - Hedgehog/intein (Hint) domain
56719 - Type II DNA topoisomerase
55608 - Homing endonucleases | 0 | Direct |
54534,54534,54534
54534 - FKBP-like
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
56712,57783,57783
56712 - Prokaryotic type I DNA topoisomerase
57783 - Zinc beta-ribbon
57783 - Zinc beta-ribbon | 0 | Direct |
52096,51735,48179
52096 - ClpP/crotonase
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52540,56712,51294
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase
51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
56741,56349,46596
56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
56349 - DNA breaking-rejoining enzymes
46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
52833,52833,47933
52833 - Thioredoxin-like
52833 - Thioredoxin-like
47933 - ERP29 C domain-like | 0 | Direct |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0 | Direct |
54534,54534,47473
54534 - FKBP-like
54534 - FKBP-like
47473 - EF-hand | 0 | Direct |
48600,51735,48179
48600 - Chorismate mutase II
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52540,52540,56712
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
56719,55608,56719
56719 - Type II DNA topoisomerase
55608 - Homing endonucleases
56719 - Type II DNA topoisomerase | 0 | Direct |
109998,54534,54534
109998 - Triger factor/SurA peptide-binding domain-like
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
51126,51120,51120
51126 - Pectin lyase-like
51120 - beta-Roll
51120 - beta-Roll | 0 | Direct |
51120,51120,51120
51120 - beta-Roll
51120 - beta-Roll
51120 - beta-Roll | 0.00000004799 | Direct |
56801,47336,52777
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.0000001582 | Direct |
47336,52777,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.000005569 | Direct |
48179,48179,52096
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
52096 - ClpP/crotonase | 0.00002211 | Direct |
52777,52777,56801
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.0001405 | Direct |
52777,56801,47336
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.0002639 | Direct |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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