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Enzyme Commission (EC): Ligases
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Class II aaRS ABD-related | 0 | DIRECT |
| Nucleic acid-binding proteins | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | 0 | DIRECT |
| An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| RuvA domain 2-like | 0 | DIRECT |
| Carbamoyl phosphate synthetase, large subunit connection domain | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Hypothetical protein PH1602 | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| FGAM synthase PurL, linker domain | 0 | DIRECT |
| Glutamine synthetase, N-terminal domain | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | DIRECT |
| tRNA-binding arm | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | DIRECT |
| Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| YbaK/ProRS associated domain | 0 | DIRECT |
| Argininosuccinate synthetase, C-terminal domain | 0 | DIRECT |
| Amidase signature (AS) enzymes | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase N-terminal domain-like | 0 | DIRECT |
| YegP-like | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| SufE/NifU | 0 | DIRECT |
| CofE-like | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| MurE/MurF N-terminal domain | 0 | DIRECT |
| GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Ribosomal protein L25-like | 0 | DIRECT |
| GAD domain-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| MurCD N-terminal domain | 0 | DIRECT |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| PurS-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| C-terminal domain of transcriptional repressors | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Anticodon-binding domain of PheRS | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| MesJ substrate recognition domain-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| MurD-like peptide ligases, catalytic domain | 0 | DIRECT |
| C-terminal domain of ProRS | 0 | DIRECT |
| PheT/TilS domain | 0 | DIRECT |
| Single hybrid motif | 0.00000000000001436 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0.0004855 | DIRECT |
| PH0987 N-terminal domain-like | 0.004195 | INHERITED FROM: Urea carboxylase || Other carbon--nitrogen ligases || Forming carbon-nitrogen bonds |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0194 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || Phosphopantothenate--cysteine ligase (CTP) || Forming carbon-nitrogen bonds |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02461 | INHERITED FROM: 5-formyltetrahydrofolate cyclo-ligase || Cyclo-ligases |
| FMN-dependent nitroreductase-like | 0.05498 | INHERITED FROM: Coenzyme F420-1:gamma-L-glutamate ligase || Acid--amino-acid ligases (peptide synthases) || Coenzyme F420-0:L-glutamate ligase || Forming carbon-nitrogen bonds |
| vWA-like | 0.08164 | INHERITED FROM: Forming nitrogen-metal bonds |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.1045 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || Forming carbon-nitrogen bonds || Phosphoribosylaminoimidazolesuccinocarboxamide synthase |
| P-loop containing nucleoside triphosphate hydrolases | 0.1419 | INHERITED FROM: Ni-sirohydrochlorin a,c-diamide synthase || Formate--tetrahydrofolate ligase || CTP synthase (glutamine hydrolyzing) || Forming nitrogen-metal bonds || Other carbon--nitrogen ligases || Dethiobiotin synthase || Cyclo-ligases || Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) || Forming carbon-nitrogen bonds || Adenylosuccinate synthase || Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing) |
| Glycerol-3-phosphate (1)-acyltransferase | 0.159 | INHERITED FROM: Forming carbon-sulfur bonds || Long-chain-fatty-acid--[acyl-carrier-protein] ligase |
| ACP-like | 0.5283 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
| Homing endonucleases | 0.6136 | INHERITED FROM: Forming phosphoric ester bonds || 3'-phosphate/5'-hydroxy nucleic acid ligase |
| SCOP hierarchy in SUPERFAMILY | 0.8351 | INHERITED FROM: Forming carbon-carbon bonds || CTP synthase (glutamine hydrolyzing) |
| Hedgehog/intein (Hint) domain | 0.9895 | INHERITED FROM: Forming phosphoric ester bonds || 3'-phosphate/5'-hydroxy nucleic acid ligase |
| EPT/RTPC-like | 1 | INHERITED FROM: RNA 3'-terminal-phosphate cyclase (ATP) || Forming phosphoric ester bonds |
| "Winged helix" DNA-binding domain | 1 | INHERITED FROM: Biotin--[biotin carboxyl-carrier protein] ligase || Phenylalanine--tRNA ligase |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | INHERITED FROM: Carbon--nitrogen ligases with glutamine as amido-N-donor || Asparagine synthase (glutamine-hydrolyzing) |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
| "Helical backbone" metal receptor | 1 | INHERITED FROM: Ni-sirohydrochlorin a,c-diamide reductive cyclase |
| Acyl-CoA N-acyltransferases (Nat) | 1 | INHERITED FROM: [Citrate (pro-3S)-lyase] ligase |
| ClpP/crotonase | 1 | INHERITED FROM: Forming carbon-carbon bonds || Biotin carboxylase |
| Carbon-nitrogen hydrolase | 1 | INHERITED FROM: NAD(+) synthase (glutamine-hydrolyzing) || Carbon--nitrogen ligases with glutamine as amido-N-donor |
| Cyclophilin-like | 1 | INHERITED FROM: Urea carboxylase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
| post-HMGL domain-like | 1 | INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Formate--tetrahydrofolate ligase |
| PLP-dependent transferases | 1 | INHERITED FROM: 6-carboxyhexanoate--CoA ligase |
| Aldolase | 1 | INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase |
| Actin-like ATPase domain | 1 | INHERITED FROM: Biotin--[biotin carboxyl-carrier protein] ligase |
| GST C-terminal domain-like | 1 | INHERITED FROM: Glutamate--tRNA ligase || Valine--tRNA ligase |
| Formyltransferase | 1 | INHERITED FROM: Phosphoribosylamine--glycine ligase || Phosphoribosylformylglycinamidine cyclo-ligase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: 5-formyltetrahydrofolate cyclo-ligase || Cyclo-ligases |
| Composite domain of metallo-dependent hydrolases | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Succinate--CoA ligase (GDP-forming) || Acetate--CoA ligase (ADP-forming) || Succinate--CoA ligase (ADP-forming) |
| Aspartate/ornithine carbamoyltransferase | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Class II aaRS ABD-related | 0 | Direct |
| Nucleic acid-binding proteins | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | 0 | Direct |
| An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 0 | Direct |
| RuvA domain 2-like | 0 | Direct |
| Carbamoyl phosphate synthetase, large subunit connection domain | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Hypothetical protein PH1602 | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| FGAM synthase PurL, linker domain | 0 | Direct |
| Glutamine synthetase, N-terminal domain | 0 | Direct |
| CoaB-like | 0 | Direct |
| RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | Direct |
| tRNA-binding arm | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | Direct |
| Adenine nucleotide alpha hydrolases-like | 0 | Direct |
| BRCT domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| YbaK/ProRS associated domain | 0 | Direct |
| Argininosuccinate synthetase, C-terminal domain | 0 | Direct |
| Amidase signature (AS) enzymes | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0 | Direct |
| Nicotinate/Quinolinate PRTase N-terminal domain-like | 0 | Direct |
| YegP-like | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| SufE/NifU | 0 | Direct |
| CofE-like | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| MurE/MurF N-terminal domain | 0 | Direct |
| GMP synthetase C-terminal dimerisation domain | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Ribosomal protein L25-like | 0 | Direct |
| GAD domain-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| MurCD N-terminal domain | 0 | Direct |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | 0 | Direct |
| Translation proteins | 0 | Direct |
| PurS-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| C-terminal domain of transcriptional repressors | 0 | Direct |
| TGS-like | 0 | Direct |
| Anticodon-binding domain of PheRS | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| MesJ substrate recognition domain-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| MurD-like peptide ligases, catalytic domain | 0 | Direct |
| C-terminal domain of ProRS | 0 | Direct |
| PheT/TilS domain | 0 | Direct |
| Single hybrid motif | 0.00000000000001436 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0.0004855 | Direct |
| PH0987 N-terminal domain-like | 0.004195 | Inherited |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.0194 | Inherited |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02461 | Inherited |
| FMN-dependent nitroreductase-like | 0.05498 | Inherited |
| vWA-like | 0.08164 | Inherited |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.1045 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.1419 | Inherited |
| Glycerol-3-phosphate (1)-acyltransferase | 0.159 | Inherited |
| ACP-like | 0.5283 | Inherited |
| Homing endonucleases | 0.6136 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.8351 | Inherited |
| Hedgehog/intein (Hint) domain | 0.9895 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| "Winged helix" DNA-binding domain | 1 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| "Helical backbone" metal receptor | 1 | Inherited |
| Acyl-CoA N-acyltransferases (Nat) | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| Carbon-nitrogen hydrolase | 1 | Inherited |
| Cyclophilin-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| post-HMGL domain-like | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Aldolase | 1 | Inherited |
| Actin-like ATPase domain | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Composite domain of metallo-dependent hydrolases | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Aspartate/ornithine carbamoyltransferase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lysine biosynthesis enzyme LysX ATP-binding domain | 0 | DIRECT |
| AlaX-like | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| PurS subunit of FGAM synthetase | 0 | DIRECT |
| ATP-binding domain of peptide synthetases | 0 | DIRECT |
| Glutathionylspermidine synthase substrate-binding domain-like | 0 | DIRECT |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | DIRECT |
| Amidase signature (AS) enzymes | 0 | DIRECT |
| GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
| PP-loop ATPase | 0 | DIRECT |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | 0 | DIRECT |
| RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | DIRECT |
| Glutamate-cysteine ligase | 0 | DIRECT |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | DIRECT |
| D-Alanine ligase N-terminal domain | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| MurCDEF C-terminal domain | 0 | DIRECT |
| Carbamoyl phosphate synthetase, large subunit connection domain | 0 | DIRECT |
| RNA ligase | 0 | DIRECT |
| Seryl-tRNA synthetase (SerRS) | 0 | DIRECT |
| Succinyl-CoA synthetase, beta-chain, N-terminal domain | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| MurCD N-terminal domain | 0 | DIRECT |
| N-type ATP pyrophosphatases | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| C-terminal domain of glutamyl-tRNA synthetase (GluRS) | 0 | DIRECT |
| SP1160 C-terminal domain-like | 0 | DIRECT |
| Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain | 0 | DIRECT |
| RNA 3'-terminal phosphate cyclase, RPTC | 0 | DIRECT |
| MurE/MurF N-terminal domain | 0 | DIRECT |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| YegP-like | 0 | DIRECT |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0 | DIRECT |
| Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like | 0 | DIRECT |
| C-terminal domain of ProRS | 0 | DIRECT |
| Adenylation domain of NAD+-dependent DNA ligase | 0 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | DIRECT |
| Phenylalanyl-tRNA synthetase (PheRS) | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| TGS domain | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Glutamine synthetase, N-terminal domain | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Hypothetical protein PH1602 | 0 | DIRECT |
| Tyrosyl-tRNA synthetase (TyrRS), C-terminal domain | 0 | DIRECT |
| Valyl-tRNA synthetase (ValRS) C-terminal domain | 0 | DIRECT |
| Eukaryotic glutathione synthetase, substrate-binding domain | 0 | DIRECT |
| Domains B1 and B5 of PheRS-beta, PheT | 0 | DIRECT |
| Methenyltetrahydrofolate synthetase | 0 | DIRECT |
| Glutamate-cysteine ligase family 2 (GCS2) | 0 | DIRECT |
| Eukaryotic glutathione synthetase ATP-binding domain | 0 | DIRECT |
| Folylpolyglutamate synthetase, C-terminal domain | 0 | DIRECT |
| AlaX-M N-terminal domain-like | 0 | DIRECT |
| MurCDEF | 0 | DIRECT |
| B3/B4 domain of PheRS, PheT | 0 | DIRECT |
| PurP ATP-binding domain-like | 0 | DIRECT |
| Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain | 0 | DIRECT |
| Glutathionylspermidine synthase ATP-binding domain-like | 0 | DIRECT |
| SAICAR synthase | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| Monomeric nicotinate phosphoribosyltransferase C-terminal domain | 0 | DIRECT |
| FGAM synthase PurL, PurS-like domain | 0 | DIRECT |
| Prokaryotic glutathione synthetase, N-terminal domain | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| CHAP domain | 0 | DIRECT |
| Anticodon-binding domain of PheRS | 0 | DIRECT |
| GAD domain | 0 | DIRECT |
| MesJ substrate recognition domain-like | 0 | DIRECT |
| C-terminal domain of class I lysyl-tRNA synthetase | 0 | DIRECT |
| Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) | 0 | DIRECT |
| CofE-like | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Argininosuccinate synthetase, C-terminal domain | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| NAD+-dependent DNA ligase, domain 3 | 0 | DIRECT |
| YbaK/ProRS associated domain | 0 | DIRECT |
| Biotin holoenzyme synthetase | 0 | DIRECT |
| Myf domain | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Glutamine synthetase catalytic domain | 0 | DIRECT |
| tRNA-Ile-lysidine synthetase, TilS, C-terminal domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| PurP N-terminal domain-like | 0 | DIRECT |
| Folylpolyglutamate synthetase | 0 | DIRECT |
| Biotin repressor (BirA) | 0 | DIRECT |
| FGAM synthase PurL, linker domain | 0 | DIRECT |
| Conserved carboxylase domain | 0.0000000000000372 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0.000000000001309 | DIRECT |
| NadC C-terminal domain-like | 0.000004132 | DIRECT |
| NadC N-terminal domain-like | 0.000009917 | DIRECT |
| PH0987 N-terminal domain-like | 0.001709 | INHERITED FROM: Urea carboxylase || Other carbon--nitrogen ligases || Forming carbon-nitrogen bonds |
| PH0987 C-terminal domain-like | 0.004521 | INHERITED FROM: Urea carboxylase || Other carbon--nitrogen ligases || Forming carbon-nitrogen bonds |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.01124 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Forming carbon-nitrogen bonds |
| Peptidyl carrier domain | 0.01592 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Forming carbon-nitrogen bonds |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.02118 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || Phosphopantothenate--cysteine ligase (CTP) || Forming carbon-nitrogen bonds |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02658 | INHERITED FROM: 5-formyltetrahydrofolate cyclo-ligase || Cyclo-ligases |
| NADH oxidase/flavin reductase | 0.112 | INHERITED FROM: Coenzyme F420-1:gamma-L-glutamate ligase || Acid--amino-acid ligases (peptide synthases) || Coenzyme F420-0:L-glutamate ligase || Forming carbon-nitrogen bonds |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.1756 | INHERITED FROM: Acid--amino-acid ligases (peptide synthases) || Phosphoribosylaminoimidazolesuccinocarboxamide synthase |
| Class II glutamine amidotransferases | 0.2004 | INHERITED FROM: Carbon--nitrogen ligases with glutamine as amido-N-donor || Forming carbon-nitrogen bonds || Asparagine synthase (glutamine-hydrolyzing) |
| LplA-like | 0.6984 | INHERITED FROM: Lipoate--protein ligase || Acid--ammonia (or amine) ligases (amide synthases) || Forming carbon-nitrogen bonds |
| CoaX-like | 1 | INHERITED FROM: Biotin--[biotin carboxyl-carrier protein] ligase |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 1 | INHERITED FROM: Formate--tetrahydrofolate ligase |
| HMGL-like | 1 | INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase |
| Deoxycytidylate deaminase-like | 1 | INHERITED FROM: tRNA(Ile)-lysidine synthetase |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 1 | INHERITED FROM: Carbon--nitrogen ligases with glutamine as amido-N-donor || Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Formate--tetrahydrofolate ligase |
| Formyltransferase | 1 | INHERITED FROM: Phosphoribosylamine--glycine ligase || Phosphoribosylformylglycinamidine cyclo-ligase |
| Nucleotide and nucleoside kinases | 1 | INHERITED FROM: Pantoate--beta-alanine ligase (AMP-forming) |
| GABA-aminotransferase-like | 1 | INHERITED FROM: 6-carboxyhexanoate--CoA ligase |
| Aspartate/ornithine carbamoyltransferase | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| Nitrogenase iron-molybdenum protein | 1 | INHERITED FROM: Ni-sirohydrochlorin a,c-diamide reductive cyclase |
| Biotin dependent carboxylase carboxyltransferase domain | 1 | INHERITED FROM: Forming carbon-carbon bonds || Biotin carboxylase |
| HD domain | 1 | INHERITED FROM: Glycine--tRNA ligase |
| Extended AAA-ATPase domain | 1 | INHERITED FROM: Forming nitrogen-metal bonds |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lysine biosynthesis enzyme LysX ATP-binding domain | 0 | Direct |
| AlaX-like | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| PurS subunit of FGAM synthetase | 0 | Direct |
| ATP-binding domain of peptide synthetases | 0 | Direct |
| Glutathionylspermidine synthase substrate-binding domain-like | 0 | Direct |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | Direct |
| Amidase signature (AS) enzymes | 0 | Direct |
| GMP synthetase C-terminal dimerisation domain | 0 | Direct |
| PP-loop ATPase | 0 | Direct |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | 0 | Direct |
| RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | Direct |
| Glutamate-cysteine ligase | 0 | Direct |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | Direct |
| D-Alanine ligase N-terminal domain | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| MurCDEF C-terminal domain | 0 | Direct |
| Carbamoyl phosphate synthetase, large subunit connection domain | 0 | Direct |
| RNA ligase | 0 | Direct |
| Seryl-tRNA synthetase (SerRS) | 0 | Direct |
| Succinyl-CoA synthetase, beta-chain, N-terminal domain | 0 | Direct |
| CoaB-like | 0 | Direct |
| MurCD N-terminal domain | 0 | Direct |
| N-type ATP pyrophosphatases | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| C-terminal domain of glutamyl-tRNA synthetase (GluRS) | 0 | Direct |
| SP1160 C-terminal domain-like | 0 | Direct |
| Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain | 0 | Direct |
| RNA 3'-terminal phosphate cyclase, RPTC | 0 | Direct |
| MurE/MurF N-terminal domain | 0 | Direct |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| YegP-like | 0 | Direct |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0 | Direct |
| Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like | 0 | Direct |
| C-terminal domain of ProRS | 0 | Direct |
| Adenylation domain of NAD+-dependent DNA ligase | 0 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | Direct |
| Phenylalanyl-tRNA synthetase (PheRS) | 0 | Direct |
| DNA ligase | 0 | Direct |
| TGS domain | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Glutamine synthetase, N-terminal domain | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Hypothetical protein PH1602 | 0 | Direct |
| Tyrosyl-tRNA synthetase (TyrRS), C-terminal domain | 0 | Direct |
| Valyl-tRNA synthetase (ValRS) C-terminal domain | 0 | Direct |
| Eukaryotic glutathione synthetase, substrate-binding domain | 0 | Direct |
| Domains B1 and B5 of PheRS-beta, PheT | 0 | Direct |
| Methenyltetrahydrofolate synthetase | 0 | Direct |
| Glutamate-cysteine ligase family 2 (GCS2) | 0 | Direct |
| Eukaryotic glutathione synthetase ATP-binding domain | 0 | Direct |
| Folylpolyglutamate synthetase, C-terminal domain | 0 | Direct |
| AlaX-M N-terminal domain-like | 0 | Direct |
| MurCDEF | 0 | Direct |
| B3/B4 domain of PheRS, PheT | 0 | Direct |
| PurP ATP-binding domain-like | 0 | Direct |
| Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain | 0 | Direct |
| Glutathionylspermidine synthase ATP-binding domain-like | 0 | Direct |
| SAICAR synthase | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| Monomeric nicotinate phosphoribosyltransferase C-terminal domain | 0 | Direct |
| FGAM synthase PurL, PurS-like domain | 0 | Direct |
| Prokaryotic glutathione synthetase, N-terminal domain | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| CHAP domain | 0 | Direct |
| Anticodon-binding domain of PheRS | 0 | Direct |
| GAD domain | 0 | Direct |
| MesJ substrate recognition domain-like | 0 | Direct |
| C-terminal domain of class I lysyl-tRNA synthetase | 0 | Direct |
| Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) | 0 | Direct |
| CofE-like | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Argininosuccinate synthetase, C-terminal domain | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| NAD+-dependent DNA ligase, domain 3 | 0 | Direct |
| YbaK/ProRS associated domain | 0 | Direct |
| Biotin holoenzyme synthetase | 0 | Direct |
| Myf domain | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Glutamine synthetase catalytic domain | 0 | Direct |
| tRNA-Ile-lysidine synthetase, TilS, C-terminal domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| PurP N-terminal domain-like | 0 | Direct |
| Folylpolyglutamate synthetase | 0 | Direct |
| Biotin repressor (BirA) | 0 | Direct |
| FGAM synthase PurL, linker domain | 0 | Direct |
| Conserved carboxylase domain | 0.0000000000000372 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0.000000000001309 | Direct |
| NadC C-terminal domain-like | 0.000004132 | Direct |
| NadC N-terminal domain-like | 0.000009917 | Direct |
| PH0987 N-terminal domain-like | 0.001709 | Inherited |
| PH0987 C-terminal domain-like | 0.004521 | Inherited |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.01124 | Inherited |
| Peptidyl carrier domain | 0.01592 | Inherited |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.02118 | Inherited |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02658 | Inherited |
| NADH oxidase/flavin reductase | 0.112 | Inherited |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.1756 | Inherited |
| Class II glutamine amidotransferases | 0.2004 | Inherited |
| LplA-like | 0.6984 | Inherited |
| CoaX-like | 1 | Inherited |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 1 | Inherited |
| HMGL-like | 1 | Inherited |
| Deoxycytidylate deaminase-like | 1 | Inherited |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| Nucleotide and nucleoside kinases | 1 | Inherited |
| GABA-aminotransferase-like | 1 | Inherited |
| Aspartate/ornithine carbamoyltransferase | 1 | Inherited |
| Nitrogenase iron-molybdenum protein | 1 | Inherited |
| Biotin dependent carboxylase carboxyltransferase domain | 1 | Inherited |
| HD domain | 1 | Inherited |
| Extended AAA-ATPase domain | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| BRCT domain | 0 | DIRECT |
| Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
| Amidase signature (AS) enzymes | 0 | DIRECT |
| C-terminal domain of ProRS | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | DIRECT |
| Argininosuccinate synthetase, C-terminal domain | 0 | DIRECT |
| RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| PurS-like | 0 | DIRECT |
| MurCD N-terminal domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Hypothetical protein PH1602 | 0 | DIRECT |
| MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
| PheT/TilS domain | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| tRNA-binding arm | 0 | DIRECT |
| C-terminal domain of transcriptional repressors | 0 | DIRECT |
| YegP-like | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Anticodon-binding domain of PheRS | 0 | DIRECT |
| Carbamoyl phosphate synthetase, large subunit connection domain | 0 | DIRECT |
| Glutamine synthetase, N-terminal domain | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| FGAM synthase PurL, linker domain | 0 | DIRECT |
| YbaK/ProRS associated domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| SufE/NifU | 0 | DIRECT |
| MurE/MurF N-terminal domain | 0 | DIRECT |
| GAD domain-like | 0 | DIRECT |
| CofE-like | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| MesJ substrate recognition domain-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Nucleic acid-binding proteins | 0 | DIRECT |
| MurD-like peptide ligases, catalytic domain | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase N-terminal domain-like | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
| CoaB-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | 0 | DIRECT |
| Ribosomal protein L25-like | 0 | DIRECT |
| RuvA domain 2-like | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Single hybrid motif | 0.0000000000000101 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0.0003971 | DIRECT |
| PH0987 N-terminal domain-like | 0.003514 | INHERITED FROM: Urea carboxylase || Other carbon--nitrogen ligases || Forming carbon-nitrogen bonds |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.01657 | INHERITED FROM: Forming carbon-nitrogen bonds || Phosphopantothenate--cysteine ligase (CTP) || Acid--amino-acid ligases (peptide synthases) |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02108 | INHERITED FROM: Forming carbon-nitrogen bonds || Cyclo-ligases || 5-formyltetrahydrofolate cyclo-ligase |
| FMN-dependent nitroreductase-like | 0.04756 | INHERITED FROM: Forming carbon-nitrogen bonds || Coenzyme F420-0:L-glutamate ligase || Acid--amino-acid ligases (peptide synthases) || Coenzyme F420-1:gamma-L-glutamate ligase |
| vWA-like | 0.071 | INHERITED FROM: Forming nitrogen-metal bonds |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.09118 | INHERITED FROM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase || Forming carbon-nitrogen bonds || Acid--amino-acid ligases (peptide synthases) |
| P-loop containing nucleoside triphosphate hydrolases | 0.1246 | INHERITED FROM: Adenylosuccinate synthase || Other carbon--nitrogen ligases || Forming carbon-nitrogen bonds || Cyclo-ligases || Dethiobiotin synthase || Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing) || Ni-sirohydrochlorin a,c-diamide synthase || CTP synthase (glutamine hydrolyzing) || Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) || Formate--tetrahydrofolate ligase || Forming nitrogen-metal bonds |
| Glycerol-3-phosphate (1)-acyltransferase | 0.14 | INHERITED FROM: Forming carbon-sulfur bonds || Long-chain-fatty-acid--[acyl-carrier-protein] ligase |
| ACP-like | 0.4833 | INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Acid--amino-acid ligases (peptide synthases) |
| Homing endonucleases | 0.5629 | INHERITED FROM: 3'-phosphate/5'-hydroxy nucleic acid ligase || Forming phosphoric ester bonds |
| Hedgehog/intein (Hint) domain | 0.9164 | INHERITED FROM: 3'-phosphate/5'-hydroxy nucleic acid ligase || Forming phosphoric ester bonds |
| "Winged helix" DNA-binding domain | 1 | INHERITED FROM: Phenylalanine--tRNA ligase || Biotin--[biotin carboxyl-carrier protein] ligase |
| ClpP/crotonase | 1 | INHERITED FROM: Biotin carboxylase || Forming carbon-carbon bonds |
| PLP-dependent transferases | 1 | INHERITED FROM: 6-carboxyhexanoate--CoA ligase |
| Cyclophilin-like | 1 | INHERITED FROM: Urea carboxylase |
| Carbon-nitrogen hydrolase | 1 | INHERITED FROM: Carbon--nitrogen ligases with glutamine as amido-N-donor || NAD(+) synthase (glutamine-hydrolyzing) |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Cyclo-ligases || 5-formyltetrahydrofolate cyclo-ligase |
| Aldolase | 1 | INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase |
| Formyltransferase | 1 | INHERITED FROM: Phosphoribosylformylglycinamidine cyclo-ligase || Phosphoribosylamine--glycine ligase |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | INHERITED FROM: Carbon--nitrogen ligases with glutamine as amido-N-donor || Asparagine synthase (glutamine-hydrolyzing) |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| GST C-terminal domain-like | 1 | INHERITED FROM: Valine--tRNA ligase || Glutamate--tRNA ligase |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
| Actin-like ATPase domain | 1 | INHERITED FROM: Biotin--[biotin carboxyl-carrier protein] ligase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Succinate--CoA ligase (GDP-forming) || Succinate--CoA ligase (ADP-forming) || Acetate--CoA ligase (ADP-forming) |
| Composite domain of metallo-dependent hydrolases | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| post-HMGL domain-like | 1 | INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase |
| EPT/RTPC-like | 1 | INHERITED FROM: Forming phosphoric ester bonds || RNA 3'-terminal-phosphate cyclase (ATP) |
| "Helical backbone" metal receptor | 1 | INHERITED FROM: Ni-sirohydrochlorin a,c-diamide reductive cyclase |
| Aspartate/ornithine carbamoyltransferase | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
| Acyl-CoA N-acyltransferases (Nat) | 1 | INHERITED FROM: [Citrate (pro-3S)-lyase] ligase |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Formate--tetrahydrofolate ligase |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| BRCT domain | 0 | Direct |
| Adenine nucleotide alpha hydrolases-like | 0 | Direct |
| Amidase signature (AS) enzymes | 0 | Direct |
| C-terminal domain of ProRS | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | Direct |
| Argininosuccinate synthetase, C-terminal domain | 0 | Direct |
| RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| PurS-like | 0 | Direct |
| MurCD N-terminal domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Hypothetical protein PH1602 | 0 | Direct |
| MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
| PheT/TilS domain | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| TGS-like | 0 | Direct |
| tRNA-binding arm | 0 | Direct |
| C-terminal domain of transcriptional repressors | 0 | Direct |
| YegP-like | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Anticodon-binding domain of PheRS | 0 | Direct |
| Carbamoyl phosphate synthetase, large subunit connection domain | 0 | Direct |
| Glutamine synthetase, N-terminal domain | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 0 | Direct |
| FGAM synthase PurL, linker domain | 0 | Direct |
| YbaK/ProRS associated domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| SufE/NifU | 0 | Direct |
| MurE/MurF N-terminal domain | 0 | Direct |
| GAD domain-like | 0 | Direct |
| CofE-like | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| MesJ substrate recognition domain-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Nucleic acid-binding proteins | 0 | Direct |
| MurD-like peptide ligases, catalytic domain | 0 | Direct |
| Translation proteins | 0 | Direct |
| Nicotinate/Quinolinate PRTase N-terminal domain-like | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| GMP synthetase C-terminal dimerisation domain | 0 | Direct |
| CoaB-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| Carbamoyl phosphate synthetase, small subunit N-terminal domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Methionyl-tRNA synthetase (MetRS), Zn-domain | 0 | Direct |
| Ribosomal protein L25-like | 0 | Direct |
| RuvA domain 2-like | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Single hybrid motif | 0.0000000000000101 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0.0003971 | Direct |
| PH0987 N-terminal domain-like | 0.003514 | Inherited |
| Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | 0.01657 | Inherited |
| Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02108 | Inherited |
| FMN-dependent nitroreductase-like | 0.04756 | Inherited |
| vWA-like | 0.071 | Inherited |
| N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0.09118 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.1246 | Inherited |
| Glycerol-3-phosphate (1)-acyltransferase | 0.14 | Inherited |
| ACP-like | 0.4833 | Inherited |
| Homing endonucleases | 0.5629 | Inherited |
| Hedgehog/intein (Hint) domain | 0.9164 | Inherited |
| "Winged helix" DNA-binding domain | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| PLP-dependent transferases | 1 | Inherited |
| Cyclophilin-like | 1 | Inherited |
| Carbon-nitrogen hydrolase | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Aldolase | 1 | Inherited |
| Formyltransferase | 1 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| GST C-terminal domain-like | 1 | Inherited |
| alpha/beta-Hydrolases | 1 | Inherited |
| Actin-like ATPase domain | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Composite domain of metallo-dependent hydrolases | 1 | Inherited |
| post-HMGL domain-like | 1 | Inherited |
| EPT/RTPC-like | 1 | Inherited |
| "Helical backbone" metal receptor | 1 | Inherited |
| Aspartate/ornithine carbamoyltransferase | 1 | Inherited |
| Acyl-CoA N-acyltransferases (Nat) | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46955,55681
46955 - Putative DNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
51735,53623
51735 - NAD(P)-binding Rossmann-fold domains
53623 - MurD-like peptide ligases, catalytic domain | 0 | DIRECT |
55681,55261
55681 - Class II aaRS and biotin synthetases
55261 - GAD domain-like | 0 | DIRECT |
54001,56059
54001 - Cysteine proteinases
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
52402,69864
52402 - Adenine nucleotide alpha hydrolases-like
69864 - Argininosuccinate synthetase, C-terminal domain | 0 | DIRECT |
52374,48163
52374 - Nucleotidylyl transferase
48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
52021,52317
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
47323,50249
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
56037,46955
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain | 0 | DIRECT |
82829,56037
82829 - MesJ substrate recognition domain-like
56037 - PheT/TilS domain | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
47323,47323
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
53623,53244
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
101353,55186
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
50249,46955
50249 - Nucleic acid-binding proteins
46955 - Putative DNA-binding domain | 0 | DIRECT |
47323,47060
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47060 - S15/NS1 RNA-binding domain | 0 | DIRECT |
50037,53067
50037 - C-terminal domain of transcriptional repressors
53067 - Actin-like ATPase domain | 0 | DIRECT |
144010,55469
144010 - CofE-like
55469 - FMN-dependent nitroreductase-like | 0 | DIRECT |
47781,52113
47781 - RuvA domain 2-like
52113 - BRCT domain | 0 | DIRECT |
55190,52374
55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
52335,51556
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
56042,52317
56042 - PurM C-terminal domain-like
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
56059,52335
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0 | DIRECT |
46955,56037
46955 - Putative DNA-binding domain
56037 - PheT/TilS domain | 0 | DIRECT |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
50249,52113
50249 - Nucleic acid-binding proteins
52113 - BRCT domain | 0 | DIRECT |
69593,56801
69593 - Glycerol-3-phosphate (1)-acyltransferase
56801 - Acetyl-CoA synthetase-like | 0 | DIRECT |
101353,50447
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
50447 - Translation proteins | 0 | DIRECT |
52374,160113
52374 - Nucleotidylyl transferase
160113 - YegP-like | 0 | DIRECT |
52540,52317
52540 - P-loop containing nucleoside triphosphate hydrolases
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
56042,55326
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 0 | DIRECT |
48108,52440
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 0 | DIRECT |
52374,50715
52374 - Nucleotidylyl transferase
50715 - Ribosomal protein L25-like | 0 | DIRECT |
55931,56059
55931 - Glutamine synthetase/guanido kinase
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
52777,53474
52777 - CoA-dependent acyltransferases
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
52402,56037
52402 - Adenine nucleotide alpha hydrolases-like
56037 - PheT/TilS domain | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
55186,55681
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
52374,55174
52374 - Nucleotidylyl transferase
55174 - Alpha-L RNA-binding motif | 0 | DIRECT |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
55205,55205
55205 - EPT/RTPC-like
55205 - EPT/RTPC-like | 0 | DIRECT |
56042,53328
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | DIRECT |
52210,52210
52210 - Succinyl-CoA synthetase domains
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
56235,52402
56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
52402 - Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
47323,46589
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
46589 - tRNA-binding arm | 0 | DIRECT |
63418,53623
63418 - MurE/MurF N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain | 0 | DIRECT |
109604,47323
109604 - HD-domain/PDEase-like
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
47060,47060
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain | 0 | DIRECT |
47616,52374
47616 - GST C-terminal domain-like
52374 - Nucleotidylyl transferase | 0 | DIRECT |
55608,103365
55608 - Homing endonucleases
103365 - Hypothetical protein PH1602 | 0 | DIRECT |
51984,53623
51984 - MurCD N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain | 0 | DIRECT |
46785,55681
46785 - "Winged helix" DNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
55681,101353
55681 - Class II aaRS and biotin synthetases
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | DIRECT |
50249,56037
50249 - Nucleic acid-binding proteins
56037 - PheT/TilS domain | 0 | DIRECT |
51735,52210
51735 - NAD(P)-binding Rossmann-fold domains
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
46589,55681
46589 - tRNA-binding arm
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
55681,55826
55681 - Class II aaRS and biotin synthetases
55826 - YbaK/ProRS associated domain | 0 | DIRECT |
52402,82829
52402 - Adenine nucleotide alpha hydrolases-like
82829 - MesJ substrate recognition domain-like | 0 | DIRECT |
52402,54810
52402 - Adenine nucleotide alpha hydrolases-like
54810 - GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
57770,52374
57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
55681,54991
55681 - Class II aaRS and biotin synthetases
54991 - Anticodon-binding domain of PheRS | 0 | DIRECT |
109736,55326
109736 - FGAM synthase PurL, linker domain
55326 - PurM N-terminal domain-like | 0 | DIRECT |
82697,109736
82697 - PurS-like
109736 - FGAM synthase PurL, linker domain | 0 | DIRECT |
103365,55608
103365 - Hypothetical protein PH1602
55608 - Homing endonucleases | 0 | DIRECT |
52317,52402
52317 - Class I glutamine amidotransferase-like
52402 - Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
51294,103365
51294 - Hedgehog/intein (Hint) domain
103365 - Hypothetical protein PH1602 | 0 | DIRECT |
55729,52374
55729 - Acyl-CoA N-acyltransferases (Nat)
52374 - Nucleotidylyl transferase | 0 | DIRECT |
47781,47781
47781 - RuvA domain 2-like
47781 - RuvA domain 2-like | 0 | DIRECT |
54675,51690
54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like
51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
52374,50249
52374 - Nucleotidylyl transferase
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
56317,52402
56317 - Carbon-nitrogen hydrolase
52402 - Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
56059,53623
56059 - Glutathione synthetase ATP-binding domain-like
53623 - MurD-like peptide ligases, catalytic domain | 0 | DIRECT |
54368,55931
54368 - Glutamine synthetase, N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
50891,160467
50891 - Cyclophilin-like
160467 - PH0987 N-terminal domain-like | 0 | DIRECT |
47060,52374
47060 - S15/NS1 RNA-binding domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
50447,55186
50447 - Translation proteins
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
51246,55326
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0 | DIRECT |
-7,52317
-7 - CATH
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
53244,52440
53244 - MurD-like peptide ligases, peptide-binding domain
52440 - PreATP-grasp domain | 0 | DIRECT |
54810,54810
54810 - GMP synthetase C-terminal dimerisation domain
54810 - GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
56037,53271
56037 - PheT/TilS domain
53271 - PRTase-like | 0 | DIRECT |
56059,52440
56059 - Glutathione synthetase ATP-binding domain-like
52440 - PreATP-grasp domain | 0 | DIRECT |
56059,48108
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 0 | DIRECT |
50249,47781
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like | 0 | DIRECT |
52317,52440
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0 | DIRECT |
52954,64586
52954 - Class II aaRS ABD-related
64586 - C-terminal domain of ProRS | 0 | DIRECT |
55681,82649
55681 - Class II aaRS and biotin synthetases
82649 - SufE/NifU | 0 | DIRECT |
55205,52913
55205 - EPT/RTPC-like
52913 - RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | DIRECT |
55681,50037
55681 - Class II aaRS and biotin synthetases
50037 - C-terminal domain of transcriptional repressors | 0 | DIRECT |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0.00000000000003936 | DIRECT |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0.0000000000003339 | DIRECT |
52374,52540
52374 - Nucleotidylyl transferase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0000000002778 | DIRECT |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0.000004909 | DIRECT |
56801,47336
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.00004601 | DIRECT |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.0001739 | DIRECT |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.001457 | INHERITED FROM: Forming carbon-nitrogen bonds || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Acid--amino-acid ligases (peptide synthases) |
160467,50891
160467 - PH0987 N-terminal domain-like
50891 - Cyclophilin-like | 0.003514 | INHERITED FROM: Urea carboxylase || Other carbon--nitrogen ligases || Forming carbon-nitrogen bonds |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0.01306 | INHERITED FROM: Ligases forming aminoacyl-tRNA and related compounds || Forming carbon-oxygen bonds || Phenylalanine--tRNA ligase |
47336,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.01595 | INHERITED FROM: Forming carbon-nitrogen bonds || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Acid--amino-acid ligases (peptide synthases) |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02108 | INHERITED FROM: Forming carbon-nitrogen bonds || Cyclo-ligases || 5-formyltetrahydrofolate cyclo-ligase |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.9257 | INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 1 | INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing) |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 1 | INHERITED FROM: Biotin--[biotin carboxyl-carrier protein] ligase |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Formate--tetrahydrofolate ligase |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 1 | INHERITED FROM: Forming carbon-carbon bonds || Pyruvate carboxylase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46955,55681
46955 - Putative DNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
51735,53623
51735 - NAD(P)-binding Rossmann-fold domains
53623 - MurD-like peptide ligases, catalytic domain | 0 | Direct |
55681,55261
55681 - Class II aaRS and biotin synthetases
55261 - GAD domain-like | 0 | Direct |
54001,56059
54001 - Cysteine proteinases
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
52402,69864
52402 - Adenine nucleotide alpha hydrolases-like
69864 - Argininosuccinate synthetase, C-terminal domain | 0 | Direct |
52374,48163
52374 - Nucleotidylyl transferase
48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 0 | Direct |
52021,52317
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
47323,50249
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
50249 - Nucleic acid-binding proteins | 0 | Direct |
56037,46955
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain | 0 | Direct |
82829,56037
82829 - MesJ substrate recognition domain-like
56037 - PheT/TilS domain | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
56104,52255
56104 - SAICAR synthase-like
52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
47323,47323
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
53623,53244
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
101353,55186
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
55186 - ThrRS/AlaRS common domain | 0 | Direct |
50249,46955
50249 - Nucleic acid-binding proteins
46955 - Putative DNA-binding domain | 0 | Direct |
47323,47060
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47060 - S15/NS1 RNA-binding domain | 0 | Direct |
50037,53067
50037 - C-terminal domain of transcriptional repressors
53067 - Actin-like ATPase domain | 0 | Direct |
144010,55469
144010 - CofE-like
55469 - FMN-dependent nitroreductase-like | 0 | Direct |
47781,52113
47781 - RuvA domain 2-like
52113 - BRCT domain | 0 | Direct |
55190,52374
55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
52374 - Nucleotidylyl transferase | 0 | Direct |
52335,51556
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | Direct |
56042,52317
56042 - PurM C-terminal domain-like
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
56059,52335
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0 | Direct |
46955,56037
46955 - Putative DNA-binding domain
56037 - PheT/TilS domain | 0 | Direct |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | Direct |
50249,52113
50249 - Nucleic acid-binding proteins
52113 - BRCT domain | 0 | Direct |
69593,56801
69593 - Glycerol-3-phosphate (1)-acyltransferase
56801 - Acetyl-CoA synthetase-like | 0 | Direct |
101353,50447
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
50447 - Translation proteins | 0 | Direct |
52374,160113
52374 - Nucleotidylyl transferase
160113 - YegP-like | 0 | Direct |
52540,52317
52540 - P-loop containing nucleoside triphosphate hydrolases
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
56042,55326
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 0 | Direct |
48108,52440
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 0 | Direct |
52374,50715
52374 - Nucleotidylyl transferase
50715 - Ribosomal protein L25-like | 0 | Direct |
55931,56059
55931 - Glutamine synthetase/guanido kinase
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
52777,53474
52777 - CoA-dependent acyltransferases
53474 - alpha/beta-Hydrolases | 0 | Direct |
52402,56037
52402 - Adenine nucleotide alpha hydrolases-like
56037 - PheT/TilS domain | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
55186,55681
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
52374,55174
52374 - Nucleotidylyl transferase
55174 - Alpha-L RNA-binding motif | 0 | Direct |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
55205,55205
55205 - EPT/RTPC-like
55205 - EPT/RTPC-like | 0 | Direct |
56042,53328
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | Direct |
52210,52210
52210 - Succinyl-CoA synthetase domains
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
56235,52402
56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
52402 - Adenine nucleotide alpha hydrolases-like | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
47323,46589
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
46589 - tRNA-binding arm | 0 | Direct |
63418,53623
63418 - MurE/MurF N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain | 0 | Direct |
109604,47323
109604 - HD-domain/PDEase-like
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
47060,47060
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain | 0 | Direct |
47616,52374
47616 - GST C-terminal domain-like
52374 - Nucleotidylyl transferase | 0 | Direct |
55608,103365
55608 - Homing endonucleases
103365 - Hypothetical protein PH1602 | 0 | Direct |
51984,53623
51984 - MurCD N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain | 0 | Direct |
46785,55681
46785 - "Winged helix" DNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
55681,101353
55681 - Class II aaRS and biotin synthetases
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 0 | Direct |
50249,56037
50249 - Nucleic acid-binding proteins
56037 - PheT/TilS domain | 0 | Direct |
51735,52210
51735 - NAD(P)-binding Rossmann-fold domains
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
46589,55681
46589 - tRNA-binding arm
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
55681,55826
55681 - Class II aaRS and biotin synthetases
55826 - YbaK/ProRS associated domain | 0 | Direct |
52402,82829
52402 - Adenine nucleotide alpha hydrolases-like
82829 - MesJ substrate recognition domain-like | 0 | Direct |
52402,54810
52402 - Adenine nucleotide alpha hydrolases-like
54810 - GMP synthetase C-terminal dimerisation domain | 0 | Direct |
57770,52374
57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
52374 - Nucleotidylyl transferase | 0 | Direct |
55681,54991
55681 - Class II aaRS and biotin synthetases
54991 - Anticodon-binding domain of PheRS | 0 | Direct |
109736,55326
109736 - FGAM synthase PurL, linker domain
55326 - PurM N-terminal domain-like | 0 | Direct |
82697,109736
82697 - PurS-like
109736 - FGAM synthase PurL, linker domain | 0 | Direct |
103365,55608
103365 - Hypothetical protein PH1602
55608 - Homing endonucleases | 0 | Direct |
52317,52402
52317 - Class I glutamine amidotransferase-like
52402 - Adenine nucleotide alpha hydrolases-like | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
51294,103365
51294 - Hedgehog/intein (Hint) domain
103365 - Hypothetical protein PH1602 | 0 | Direct |
55729,52374
55729 - Acyl-CoA N-acyltransferases (Nat)
52374 - Nucleotidylyl transferase | 0 | Direct |
47781,47781
47781 - RuvA domain 2-like
47781 - RuvA domain 2-like | 0 | Direct |
54675,51690
54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like
51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
52374,50249
52374 - Nucleotidylyl transferase
50249 - Nucleic acid-binding proteins | 0 | Direct |
56317,52402
56317 - Carbon-nitrogen hydrolase
52402 - Adenine nucleotide alpha hydrolases-like | 0 | Direct |
56059,53623
56059 - Glutathione synthetase ATP-binding domain-like
53623 - MurD-like peptide ligases, catalytic domain | 0 | Direct |
54368,55931
54368 - Glutamine synthetase, N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
50891,160467
50891 - Cyclophilin-like
160467 - PH0987 N-terminal domain-like | 0 | Direct |
47060,52374
47060 - S15/NS1 RNA-binding domain
52374 - Nucleotidylyl transferase | 0 | Direct |
50447,55186
50447 - Translation proteins
55186 - ThrRS/AlaRS common domain | 0 | Direct |
51246,55326
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0 | Direct |
-7,52317
-7 - CATH
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
53244,52440
53244 - MurD-like peptide ligases, peptide-binding domain
52440 - PreATP-grasp domain | 0 | Direct |
54810,54810
54810 - GMP synthetase C-terminal dimerisation domain
54810 - GMP synthetase C-terminal dimerisation domain | 0 | Direct |
56037,53271
56037 - PheT/TilS domain
53271 - PRTase-like | 0 | Direct |
56059,52440
56059 - Glutathione synthetase ATP-binding domain-like
52440 - PreATP-grasp domain | 0 | Direct |
56059,48108
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 0 | Direct |
50249,47781
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like | 0 | Direct |
52317,52440
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0 | Direct |
52954,64586
52954 - Class II aaRS ABD-related
64586 - C-terminal domain of ProRS | 0 | Direct |
55681,82649
55681 - Class II aaRS and biotin synthetases
82649 - SufE/NifU | 0 | Direct |
55205,52913
55205 - EPT/RTPC-like
52913 - RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | Direct |
55681,50037
55681 - Class II aaRS and biotin synthetases
50037 - C-terminal domain of transcriptional repressors | 0 | Direct |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0.00000000000003936 | Direct |
52507,102645
52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
102645 - CoaB-like | 0.0000000000003339 | Direct |
52374,52540
52374 - Nucleotidylyl transferase
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0000000002778 | Direct |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0.000004909 | Direct |
56801,47336
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.00004601 | Direct |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.0001739 | Direct |
52777,56801
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.001457 | Inherited |
160467,50891
160467 - PH0987 N-terminal domain-like
50891 - Cyclophilin-like | 0.003514 | Inherited |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0.01306 | Inherited |
47336,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.01595 | Inherited |
55116,55116
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. | 0.02108 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.9257 | Inherited |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 1 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 1 | Inherited |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
51569,89000
51569 - Aldolase
89000 - post-HMGL domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
109736,55326,56042
109736 - FGAM synthase PurL, linker domain
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
55681,50037,53067
55681 - Class II aaRS and biotin synthetases
50037 - C-terminal domain of transcriptional repressors
53067 - Actin-like ATPase domain | 0 | DIRECT |
47616,52374,50715
47616 - GST C-terminal domain-like
52374 - Nucleotidylyl transferase
50715 - Ribosomal protein L25-like | 0 | DIRECT |
53623,53244,52440
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain
52440 - PreATP-grasp domain | 0 | DIRECT |
47060,47060,47060
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain | 0 | DIRECT |
47060,55681,52954
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
56091,50249,47781
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like | 0 | DIRECT |
82697,109736,55326
82697 - PurS-like
109736 - FGAM synthase PurL, linker domain
55326 - PurM N-terminal domain-like | 0 | DIRECT |
55326,56042,53328
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | DIRECT |
47781,47781,52113
47781 - RuvA domain 2-like
47781 - RuvA domain 2-like
52113 - BRCT domain | 0 | DIRECT |
48108,52440,56059
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
56059,51246,55326
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0 | DIRECT |
51984,53623,53244
51984 - MurCD N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
50891,160467,50891
50891 - Cyclophilin-like
160467 - PH0987 N-terminal domain-like
50891 - Cyclophilin-like | 0 | DIRECT |
55205,55205,52913
55205 - EPT/RTPC-like
55205 - EPT/RTPC-like
52913 - RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | DIRECT |
52317,52440,56059
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
81271,55186,55681
81271 - TGS-like
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
55326,56042,52317
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
46955,55681,54991
46955 - Putative DNA-binding domain
55681 - Class II aaRS and biotin synthetases
54991 - Anticodon-binding domain of PheRS | 0 | DIRECT |
50249,46955,56037
50249 - Nucleic acid-binding proteins
46955 - Putative DNA-binding domain
56037 - PheT/TilS domain | 0 | DIRECT |
51735,52210,52210
51735 - NAD(P)-binding Rossmann-fold domains
52210 - Succinyl-CoA synthetase domains
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
55326,56042,55326
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 0 | DIRECT |
50249,52113,52113
50249 - Nucleic acid-binding proteins
52113 - BRCT domain
52113 - BRCT domain | 0 | DIRECT |
55681,101353,50447
55681 - Class II aaRS and biotin synthetases
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
50447 - Translation proteins | 0 | DIRECT |
52317,52402,54810
52317 - Class I glutamine amidotransferase-like
52402 - Adenine nucleotide alpha hydrolases-like
54810 - GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
50037,53067,53067
50037 - C-terminal domain of transcriptional repressors
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
52374,47323,47060
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47060 - S15/NS1 RNA-binding domain | 0 | DIRECT |
52440,56059,48108
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 0 | DIRECT |
52374,47323,46589
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
46589 - tRNA-binding arm | 0 | DIRECT |
63418,53623,53244
63418 - MurE/MurF N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
55186,55681,52954
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
52335,51556,51338
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
50249,55681,55261
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases
55261 - GAD domain-like | 0 | DIRECT |
52021,52317,52440
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0 | DIRECT |
56037,46955,55681
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
50677,52374,47323
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
56059,52335,51556
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
52440,56059,52335
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0 | DIRECT |
55190,52374,47323
55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
56091,50249,52113
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins
52113 - BRCT domain | 0 | DIRECT |
56059,53623,53244
56059 - Glutathione synthetase ATP-binding domain-like
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
46955,56037,46955
46955 - Putative DNA-binding domain
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain | 0 | DIRECT |
101353,50447,55186
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
50447 - Translation proteins
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
52777,52777,53474
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
51294,103365,55608
51294 - Hedgehog/intein (Hint) domain
103365 - Hypothetical protein PH1602
55608 - Homing endonucleases | 0 | DIRECT |
56042,55326,56042
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
55681,101353,55186
55681 - Class II aaRS and biotin synthetases
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
57770,52374,47323
57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
52374,47323,50249
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
46785,55681,50037
46785 - "Winged helix" DNA-binding domain
55681 - Class II aaRS and biotin synthetases
50037 - C-terminal domain of transcriptional repressors | 0 | DIRECT |
47060,47060,55681
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
51246,55326,56042
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
50249,47781,47781
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like
47781 - RuvA domain 2-like | 0 | DIRECT |
53244,52440,56059
53244 - MurD-like peptide ligases, peptide-binding domain
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
103365,55608,103365
103365 - Hypothetical protein PH1602
55608 - Homing endonucleases
103365 - Hypothetical protein PH1602 | 0 | DIRECT |
54001,56059,52440
54001 - Cysteine proteinases
56059 - Glutathione synthetase ATP-binding domain-like
52440 - PreATP-grasp domain | 0 | DIRECT |
50249,56037,46955
50249 - Nucleic acid-binding proteins
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain | 0 | DIRECT |
50249,47781,52113
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like
52113 - BRCT domain | 0 | DIRECT |
56059,48108,52440
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 0 | DIRECT |
82829,56037,53271
82829 - MesJ substrate recognition domain-like
56037 - PheT/TilS domain
53271 - PRTase-like | 0 | DIRECT |
52402,54810,54810
52402 - Adenine nucleotide alpha hydrolases-like
54810 - GMP synthetase C-terminal dimerisation domain
54810 - GMP synthetase C-terminal dimerisation domain | 0 | DIRECT |
52402,82829,56037
52402 - Adenine nucleotide alpha hydrolases-like
82829 - MesJ substrate recognition domain-like
56037 - PheT/TilS domain | 0 | DIRECT |
51735,53623,53244
51735 - NAD(P)-binding Rossmann-fold domains
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | DIRECT |
55681,52954,64586
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related
64586 - C-terminal domain of ProRS | 0 | DIRECT |
52540,-7,52317
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH
52317 - Class I glutamine amidotransferase-like | 0 | DIRECT |
52777,52777,56801
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.0002781 | DIRECT |
52777,56801,47336
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.0006155 | DIRECT |
56801,47336,52777
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.002131 | INHERITED FROM: Forming carbon-nitrogen bonds || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Acid--amino-acid ligases (peptide synthases) |
47336,52777,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.01595 | INHERITED FROM: Forming carbon-nitrogen bonds || N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase || Acid--amino-acid ligases (peptide synthases) |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
109736,55326,56042
109736 - FGAM synthase PurL, linker domain
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
55681,50037,53067
55681 - Class II aaRS and biotin synthetases
50037 - C-terminal domain of transcriptional repressors
53067 - Actin-like ATPase domain | 0 | Direct |
47616,52374,50715
47616 - GST C-terminal domain-like
52374 - Nucleotidylyl transferase
50715 - Ribosomal protein L25-like | 0 | Direct |
53623,53244,52440
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain
52440 - PreATP-grasp domain | 0 | Direct |
47060,47060,47060
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain | 0 | Direct |
47060,55681,52954
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
56091,50249,47781
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like | 0 | Direct |
82697,109736,55326
82697 - PurS-like
109736 - FGAM synthase PurL, linker domain
55326 - PurM N-terminal domain-like | 0 | Direct |
55326,56042,53328
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
53328 - Formyltransferase | 0 | Direct |
47781,47781,52113
47781 - RuvA domain 2-like
47781 - RuvA domain 2-like
52113 - BRCT domain | 0 | Direct |
48108,52440,56059
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
56059,51246,55326
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like | 0 | Direct |
51984,53623,53244
51984 - MurCD N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
50891,160467,50891
50891 - Cyclophilin-like
160467 - PH0987 N-terminal domain-like
50891 - Cyclophilin-like | 0 | Direct |
55205,55205,52913
55205 - EPT/RTPC-like
55205 - EPT/RTPC-like
52913 - RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 0 | Direct |
52317,52440,56059
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
81271,55186,55681
81271 - TGS-like
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
55326,56042,52317
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
46955,55681,54991
46955 - Putative DNA-binding domain
55681 - Class II aaRS and biotin synthetases
54991 - Anticodon-binding domain of PheRS | 0 | Direct |
50249,46955,56037
50249 - Nucleic acid-binding proteins
46955 - Putative DNA-binding domain
56037 - PheT/TilS domain | 0 | Direct |
51735,52210,52210
51735 - NAD(P)-binding Rossmann-fold domains
52210 - Succinyl-CoA synthetase domains
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
55326,56042,55326
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like | 0 | Direct |
50249,52113,52113
50249 - Nucleic acid-binding proteins
52113 - BRCT domain
52113 - BRCT domain | 0 | Direct |
55681,101353,50447
55681 - Class II aaRS and biotin synthetases
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
50447 - Translation proteins | 0 | Direct |
52317,52402,54810
52317 - Class I glutamine amidotransferase-like
52402 - Adenine nucleotide alpha hydrolases-like
54810 - GMP synthetase C-terminal dimerisation domain | 0 | Direct |
50037,53067,53067
50037 - C-terminal domain of transcriptional repressors
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
52374,47323,47060
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47060 - S15/NS1 RNA-binding domain | 0 | Direct |
52440,56059,48108
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain | 0 | Direct |
52374,47323,46589
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
46589 - tRNA-binding arm | 0 | Direct |
63418,53623,53244
63418 - MurE/MurF N-terminal domain
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
55186,55681,52954
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
52335,51556,51338
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
50249,55681,55261
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases
55261 - GAD domain-like | 0 | Direct |
52021,52317,52440
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
52317 - Class I glutamine amidotransferase-like
52440 - PreATP-grasp domain | 0 | Direct |
56037,46955,55681
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
50677,52374,47323
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
56059,52335,51556
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like
51556 - Metallo-dependent hydrolases | 0 | Direct |
52440,56059,52335
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
52335 - Methylglyoxal synthase-like | 0 | Direct |
55190,52374,47323
55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
56091,50249,52113
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins
52113 - BRCT domain | 0 | Direct |
56059,53623,53244
56059 - Glutathione synthetase ATP-binding domain-like
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
46955,56037,46955
46955 - Putative DNA-binding domain
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain | 0 | Direct |
101353,50447,55186
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
50447 - Translation proteins
55186 - ThrRS/AlaRS common domain | 0 | Direct |
52777,52777,53474
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases
53474 - alpha/beta-Hydrolases | 0 | Direct |
51294,103365,55608
51294 - Hedgehog/intein (Hint) domain
103365 - Hypothetical protein PH1602
55608 - Homing endonucleases | 0 | Direct |
56042,55326,56042
56042 - PurM C-terminal domain-like
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
55681,101353,55186
55681 - Class II aaRS and biotin synthetases
101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
55186 - ThrRS/AlaRS common domain | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
57770,52374,47323
57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
52374,47323,50249
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
50249 - Nucleic acid-binding proteins | 0 | Direct |
46785,55681,50037
46785 - "Winged helix" DNA-binding domain
55681 - Class II aaRS and biotin synthetases
50037 - C-terminal domain of transcriptional repressors | 0 | Direct |
47060,47060,55681
47060 - S15/NS1 RNA-binding domain
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
51246,55326,56042
51246 - Rudiment single hybrid motif
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
50249,47781,47781
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like
47781 - RuvA domain 2-like | 0 | Direct |
53244,52440,56059
53244 - MurD-like peptide ligases, peptide-binding domain
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
103365,55608,103365
103365 - Hypothetical protein PH1602
55608 - Homing endonucleases
103365 - Hypothetical protein PH1602 | 0 | Direct |
54001,56059,52440
54001 - Cysteine proteinases
56059 - Glutathione synthetase ATP-binding domain-like
52440 - PreATP-grasp domain | 0 | Direct |
50249,56037,46955
50249 - Nucleic acid-binding proteins
56037 - PheT/TilS domain
46955 - Putative DNA-binding domain | 0 | Direct |
50249,47781,52113
50249 - Nucleic acid-binding proteins
47781 - RuvA domain 2-like
52113 - BRCT domain | 0 | Direct |
56059,48108,52440
56059 - Glutathione synthetase ATP-binding domain-like
48108 - Carbamoyl phosphate synthetase, large subunit connection domain
52440 - PreATP-grasp domain | 0 | Direct |
82829,56037,53271
82829 - MesJ substrate recognition domain-like
56037 - PheT/TilS domain
53271 - PRTase-like | 0 | Direct |
52402,54810,54810
52402 - Adenine nucleotide alpha hydrolases-like
54810 - GMP synthetase C-terminal dimerisation domain
54810 - GMP synthetase C-terminal dimerisation domain | 0 | Direct |
52402,82829,56037
52402 - Adenine nucleotide alpha hydrolases-like
82829 - MesJ substrate recognition domain-like
56037 - PheT/TilS domain | 0 | Direct |
51735,53623,53244
51735 - NAD(P)-binding Rossmann-fold domains
53623 - MurD-like peptide ligases, catalytic domain
53244 - MurD-like peptide ligases, peptide-binding domain | 0 | Direct |
55681,52954,64586
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related
64586 - C-terminal domain of ProRS | 0 | Direct |
52540,-7,52317
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH
52317 - Class I glutamine amidotransferase-like | 0 | Direct |
52777,52777,56801
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like | 0.0002781 | Direct |
52777,56801,47336
52777 - CoA-dependent acyltransferases
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like | 0.0006155 | Direct |
56801,47336,52777
56801 - Acetyl-CoA synthetase-like
47336 - ACP-like
52777 - CoA-dependent acyltransferases | 0.002131 | Inherited |
47336,52777,52777
47336 - ACP-like
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.01595 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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