Enzyme Commission (EC): Ligases forming aminoacyl-tRNA and related compounds

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: root [root] <7>

+ + 2: Ligases [6] <6> (98|123) (97|115|71)

+ 1: Forming carbon-oxygen bonds [6.1] <3> (28|31) (28|37|22)

0: Ligases forming aminoacyl-tRNA and related compounds [6.1.1] <30> (27|30) (27|37|22)

- 1: Alanine--tRNA ligase [6.1.1.7] (4|4) (4|4|3)

- 1: Arginine--tRNA ligase [6.1.1.19] (3|3) (3|2|1)

- 1: Asparagine--tRNA ligase [6.1.1.22] (2|2) (2|1|0)

- 1: Aspartate--tRNA ligase [6.1.1.12] (3|3) (3|2|1)

- 1: Aspartate--tRNA(Asn) ligase [6.1.1.23] (3|3) (3|2|1)

- 1: Cysteine--tRNA ligase [6.1.1.16] (2|2) (2|1|0)

- 1: D-alanine--poly(phosphoribitol) ligase [6.1.1.13] (0|0) (0|0|0)

- 1: Deleted entry [6.1.1.25] (0|0) (0|0|0)

- 1: Deleted entry [6.1.1.8] (0|0) (0|0|0)

- 1: Deleted entry [6.1.1.28] (0|0) (0|0|0)

- 1: Glutamate--tRNA ligase [6.1.1.17] (4|3) (4|4|3)

- 1: Glutamate--tRNA(Gln) ligase [6.1.1.24] (0|0) (0|0|0)

- 1: Glutamine--tRNA ligase [6.1.1.18] (2|2) (2|1|0)

- 1: Glycine--tRNA ligase [6.1.1.14] (1|3) (1|2|0)

- 1: Histidine--tRNA ligase [6.1.1.21] (3|3) (3|2|1)

- 1: Isoleucine--tRNA ligase [6.1.1.5] (3|3) (3|2|0)

- 1: Leucine--tRNA ligase [6.1.1.4] (3|3) (3|2|1)

- 1: Lysine--tRNA ligase [6.1.1.6] (2|3) (2|1|0)

- 1: Methionine--tRNA ligase [6.1.1.10] (4|4) (4|4|3)

- 1: O-phosphoserine--tRNA ligase [6.1.1.27] (0|0) (0|0|0)

- 1: Phenylalanine--tRNA ligase [6.1.1.20] (7|6) (7|8|5)

- 1: Proline--tRNA ligase [6.1.1.15] (4|4) (4|5|4)

- 1: Pyrrolysine--tRNA(Pyl) ligase [6.1.1.26] (0|0) (0|0|0)

- 1: Serine--tRNA ligase [6.1.1.11] (2|2) (2|1|0)

- 1: Threonine--tRNA ligase [6.1.1.3] (4|4) (4|3|2)

- 1: Transferred entry: 6.1.1.27 [6.1.1.n2] (0|0) (0|0|0)

- 1: Transferred entry: 6.3.1.13 [6.1.1.n1] (0|0) (0|0|0)

- 1: Tryptophan--tRNA ligase [6.1.1.2] (3|3) (3|2|0)

- 1: Tyrosine--tRNA ligase [6.1.1.1] (2|2) (2|2|0)

- 1: Valine--tRNA ligase [6.1.1.9] (5|4) (5|2|1)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Class II aaRS ABD-related	0	Direct
Nucleic acid-binding proteins	0	Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain	0	Direct
An anticodon-binding domain of class I aminoacyl-tRNA synthetases	0	Direct
Alpha-L RNA-binding motif	0	Direct
S15/NS1 RNA-binding domain	0	Direct
tRNA-binding arm	0	Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	Direct
ThrRS/AlaRS common domain	0	Direct
YbaK/ProRS associated domain	0	Direct
Nucleotidylyl transferase	0	Direct
YegP-like	0	Direct
Class II aaRS and biotin synthetases	0	Direct
HD-domain/PDEase-like	0	Direct
Ribosomal protein L25-like	0	Direct
GAD domain-like	0	Direct
ValRS/IleRS/LeuRS editing domain	0	Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	0	Direct
Translation proteins	0	Direct
TGS-like	0	Direct
Anticodon-binding domain of PheRS	0	Direct
Putative DNA-binding domain	0	Direct
C-terminal domain of ProRS	0	Direct
PheT/TilS domain	0	Direct
GST C-terminal domain-like	0.8462	Inherited
"Winged helix" DNA-binding domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
AlaX-like	0	Direct
Threonyl-tRNA synthetase (ThrRS), second 'additional' domain	0	Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	0	Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	Direct
Seryl-tRNA synthetase (SerRS)	0	Direct
C-terminal domain of glutamyl-tRNA synthetase (GluRS)	0	Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain	0	Direct
YegP-like	0	Direct
C-terminal domain of ProRS	0	Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	Direct
Phenylalanyl-tRNA synthetase (PheRS)	0	Direct
TGS domain	0	Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
a tRNA synthase domain	0	Direct
Tyrosyl-tRNA synthetase (TyrRS), C-terminal domain	0	Direct
Valyl-tRNA synthetase (ValRS) C-terminal domain	0	Direct
Domains B1 and B5 of PheRS-beta, PheT	0	Direct
AlaX-M N-terminal domain-like	0	Direct
B3/B4 domain of PheRS, PheT	0	Direct
Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain	0	Direct
Anticodon-binding domain of PheRS	0	Direct
GAD domain	0	Direct
C-terminal domain of class I lysyl-tRNA synthetase	0	Direct
Anticodon-binding domain of Class II aaRS	0	Direct
YbaK/ProRS associated domain	0	Direct
Myf domain	0	Direct
Anticodon-binding domain	0	Direct
ValRS/IleRS/LeuRS editing domain	0	Direct
HD domain	0.7518	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
C-terminal domain of ProRS	0	Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	Direct
Putative DNA-binding domain	0	Direct
PheT/TilS domain	0	Direct
TGS-like	0	Direct
tRNA-binding arm	0	Direct
YegP-like	0	Direct
Alpha-L RNA-binding motif	0	Direct
Anticodon-binding domain of PheRS	0	Direct
An anticodon-binding domain of class I aminoacyl-tRNA synthetases	0	Direct
YbaK/ProRS associated domain	0	Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
GAD domain-like	0	Direct
Nucleotidylyl transferase	0	Direct
Class II aaRS and biotin synthetases	0	Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	0	Direct
HD-domain/PDEase-like	0	Direct
Nucleic acid-binding proteins	0	Direct
Translation proteins	0	Direct
ThrRS/AlaRS common domain	0	Direct
Class II aaRS ABD-related	0	Direct
S15/NS1 RNA-binding domain	0	Direct
ValRS/IleRS/LeuRS editing domain	0	Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain	0	Direct
Ribosomal protein L25-like	0	Direct
GST C-terminal domain-like	0.7801	Inherited
"Winged helix" DNA-binding domain	1	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
46955,55681 46955 - Putative DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	Direct
55681,55261 55681 - Class II aaRS and biotin synthetases 55261 - GAD domain-like	0	Direct
52374,48163 52374 - Nucleotidylyl transferase 48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases	0	Direct
47323,50249 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 50249 - Nucleic acid-binding proteins	0	Direct
56037,46955 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain	0	Direct
47060,55681 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	Direct
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0	Direct
47323,47323 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
101353,55186 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 55186 - ThrRS/AlaRS common domain	0	Direct
50249,46955 50249 - Nucleic acid-binding proteins 46955 - Putative DNA-binding domain	0	Direct
47323,47060 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 47060 - S15/NS1 RNA-binding domain	0	Direct
55190,52374 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain 52374 - Nucleotidylyl transferase	0	Direct
46955,56037 46955 - Putative DNA-binding domain 56037 - PheT/TilS domain	0	Direct
81271,55186 81271 - TGS-like 55186 - ThrRS/AlaRS common domain	0	Direct
101353,50447 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 50447 - Translation proteins	0	Direct
52374,160113 52374 - Nucleotidylyl transferase 160113 - YegP-like	0	Direct
52374,50715 52374 - Nucleotidylyl transferase 50715 - Ribosomal protein L25-like	0	Direct
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
55186,55681 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	Direct
52374,55174 52374 - Nucleotidylyl transferase 55174 - Alpha-L RNA-binding motif	0	Direct
47323,46589 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 46589 - tRNA-binding arm	0	Direct
109604,47323 109604 - HD-domain/PDEase-like 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
47060,47060 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain	0	Direct
47616,52374 47616 - GST C-terminal domain-like 52374 - Nucleotidylyl transferase	0	Direct
55681,101353 55681 - Class II aaRS and biotin synthetases 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	Direct
50249,56037 50249 - Nucleic acid-binding proteins 56037 - PheT/TilS domain	0	Direct
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	Direct
46589,55681 46589 - tRNA-binding arm 55681 - Class II aaRS and biotin synthetases	0	Direct
55681,55826 55681 - Class II aaRS and biotin synthetases 55826 - YbaK/ProRS associated domain	0	Direct
57770,52374 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain 52374 - Nucleotidylyl transferase	0	Direct
55681,54991 55681 - Class II aaRS and biotin synthetases 54991 - Anticodon-binding domain of PheRS	0	Direct
52374,50249 52374 - Nucleotidylyl transferase 50249 - Nucleic acid-binding proteins	0	Direct
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	Direct
47060,52374 47060 - S15/NS1 RNA-binding domain 52374 - Nucleotidylyl transferase	0	Direct
50447,55186 50447 - Translation proteins 55186 - ThrRS/AlaRS common domain	0	Direct
52954,64586 52954 - Class II aaRS ABD-related 64586 - C-terminal domain of ProRS	0	Direct
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0.0009153	Direct

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47616,52374,50715 47616 - GST C-terminal domain-like 52374 - Nucleotidylyl transferase 50715 - Ribosomal protein L25-like	0	Direct
47060,47060,47060 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain	0	Direct
47060,55681,52954 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	Direct
81271,55186,55681 81271 - TGS-like 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	Direct
46955,55681,54991 46955 - Putative DNA-binding domain 55681 - Class II aaRS and biotin synthetases 54991 - Anticodon-binding domain of PheRS	0	Direct
50249,46955,56037 50249 - Nucleic acid-binding proteins 46955 - Putative DNA-binding domain 56037 - PheT/TilS domain	0	Direct
55681,101353,50447 55681 - Class II aaRS and biotin synthetases 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 50447 - Translation proteins	0	Direct
52374,47323,47060 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 47060 - S15/NS1 RNA-binding domain	0	Direct
52374,47323,46589 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 46589 - tRNA-binding arm	0	Direct
55186,55681,52954 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	Direct
50249,55681,55261 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases 55261 - GAD domain-like	0	Direct
56037,46955,55681 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	Direct
50677,52374,47323 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
55190,52374,47323 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
46955,56037,46955 46955 - Putative DNA-binding domain 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain	0	Direct
101353,50447,55186 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 50447 - Translation proteins 55186 - ThrRS/AlaRS common domain	0	Direct
55681,101353,55186 55681 - Class II aaRS and biotin synthetases 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 55186 - ThrRS/AlaRS common domain	0	Direct
57770,52374,47323 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	Direct
52374,47323,50249 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 50249 - Nucleic acid-binding proteins	0	Direct
47060,47060,55681 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	Direct
50249,56037,46955 50249 - Nucleic acid-binding proteins 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain	0	Direct
55681,52954,64586 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related 64586 - C-terminal domain of ProRS	0	Direct

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Enzyme Commission (EC): Ligases forming aminoacyl-tRNA and related compounds

Superfamily

Family

Supra-domain (including individual superfamily)