SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.

  Home > Phenotype Ontology > Acid--thiol ligases

Enzyme Commission (EC): Acid--thiol ligases

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Ligases [6] <6>(98|123) (97|115|71)
+ 1:   Forming carbon-sulfur bonds [6.2] <1>(10|6) (10|7|1)
0:   Acid--thiol ligases [6.2.1] <60>(10|6) (10|6|1)
- 1:   (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase [6.2.1.38](0|0) (0|0|0)
- 1:   -CoA ligase [6.2.1.41](0|0) (0|0|0)
- 1:   2-furoate--CoA ligase [6.2.1.31](0|0) (0|0|0)
- 1:   2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase [6.2.1.43](0|0) (0|0|0)
- 1:   3-(methylthio)propionyl--CoA ligase [6.2.1.44](0|0) (0|0|0)
- 1:   3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase [6.2.1.28](0|0) (0|0|0)
- 1:   3-hydroxybenzoate--CoA ligase [6.2.1.37](0|0) (0|0|0)
- 1:   3-hydroxypropionyl-CoA synthase [6.2.1.36](0|0) (0|0|0)
- 1:   3-oxocholest-4-en-26-oate--CoA ligase [6.2.1.42](0|0) (0|0|0)
- 1:   4-chlorobenzoate--CoA ligase [6.2.1.33](0|0) (0|0|0)
- 1:   4-coumarate--CoA ligase [6.2.1.12](1|1) (1|0|0)
- 1:   4-hydroxybenzoate adenylyltransferase FadD22 [6.2.1.50](0|0) (0|0|0)
- 1:   4-hydroxybenzoate--CoA ligase [6.2.1.27](0|0) (0|0|0)
- 1:   4-hydroxybutyrate--CoA ligase (ADP-forming) [6.2.1.56](0|0) (0|0|0)
- 1:   4-hydroxybutyrate--CoA ligase (AMP-forming) [6.2.1.40](0|0) (0|0|0)
- 1:   4-hydroxyphenylalkanoate adenylyltransferase FadD29 [6.2.1.51](0|0) (0|0|0)
- 1:   6-carboxyhexanoate--CoA ligase [6.2.1.14](1|1) (1|0|0)
- 1:   Acetate--CoA ligase [6.2.1.1](1|1) (1|0|0)
- 1:   Acetate--CoA ligase (ADP-forming) [6.2.1.13](1|1) (1|2|1)
- 1:   Acetate--[acyl-carrier protein] ligase [6.2.1.35](0|0) (0|0|0)
- 1:   Acetoacetate--CoA ligase [6.2.1.16](0|0) (0|0|0)
- 1:   Acid--CoA ligase (GDP-forming) [6.2.1.10](0|0) (0|0|0)
- 1:   Amino acid--[acyl-carrier-protein] ligase [6.2.1.n2](1|0) (1|0|0)
- 1:   Anthranilate--CoA ligase [6.2.1.32](0|0) (0|0|0)
- 1:   Arachidonate--CoA ligase [6.2.1.15](1|1) (1|0|0)
- 1:   Benzoate--CoA ligase [6.2.1.25](0|0) (0|0|0)
- 1:   Biotin--CoA ligase [6.2.1.11](0|0) (0|0|0)
- 1:   Carnitine--CoA ligase [6.2.1.48](1|1) (1|0|0)
- 1:   Cholate--CoA ligase [6.2.1.7](0|0) (0|0|0)
- 1:   Citrate--CoA ligase [6.2.1.18](0|0) (0|0|0)
- 1:   D-alanine--[D-alanyl-carrier protein] ligase [6.2.1.54](1|1) (1|0|0)
- 1:   Dicarboxylate--CoA ligase [6.2.1.23](0|0) (0|0|0)
- 1:   E1 SAMP-activating enzyme [6.2.1.55](0|0) (0|0|0)
- 1:   E1 ubiquitin-activating enzyme [6.2.1.45](1|1) (1|1|0)
- 1:   Glutarate--CoA ligase [6.2.1.6](0|0) (0|0|0)
- 1:   L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase [6.2.1.46](0|0) (0|0|0)
- 1:   L-firefly luciferin--CoA ligase [6.2.1.52](0|0) (0|0|0)
- 1:   L-proline--[L-prolyl-carrier protein] ligase [6.2.1.53](0|0) (0|0|0)
- 1:   Long-chain fatty acid adenylase/transferase FadD23 [6.2.1.57](0|0) (0|0|0)
- 1:   Long-chain fatty acid adenylyltransferase FadD28 [6.2.1.49](0|0) (0|0|0)
- 1:   Long-chain-fatty-acid--CoA ligase [6.2.1.3](1|1) (1|0|0)
- 1:   Long-chain-fatty-acid--[acyl-carrier-protein] ligase [6.2.1.20](2|1) (2|1|0)
- 1:   Long-chain-fatty-acid--protein ligase [6.2.1.19](0|0) (0|0|0)
- 1:   Malate--CoA ligase [6.2.1.9](0|0) (0|0|0)
- 1:   Malonate--CoA ligase [6.2.1.n3](0|0) (0|0|0)
- 1:   Medium-chain acyl-CoA ligase [6.2.1.2](1|1) (1|0|0)
- 1:   Medium-chain-fatty-acid--(acyl-carrier-protein) ligase [6.2.1.47](0|0) (0|0|0)
- 1:   Oxalate--CoA ligase [6.2.1.8](0|0) (0|0|0)
- 1:   Phenylacetate--CoA ligase [6.2.1.30](0|0) (0|0|0)
- 1:   Phytanate--CoA ligase [6.2.1.24](0|0) (0|0|0)
- 1:   Propionate--CoA ligase [6.2.1.17](0|0) (0|0|0)
- 1:   Succinate--CoA ligase (ADP-forming) [6.2.1.5](3|3) (3|2|0)
- 1:   Succinate--CoA ligase (GDP-forming) [6.2.1.4](1|1) (1|1|0)
- 1:   Trans-feruloyl-CoA synthase [6.2.1.34](0|0) (0|0|0)
- 1:   Transferred entry: 6.2.1.30 [6.2.1.21](0|0) (0|0|0)
- 1:   Transferred entry: 6.2.1.37 [6.2.1.n1](0|0) (0|0|0)
- 1:   Transferred entry: 6.2.1.7 [6.2.1.29](0|0) (0|0|0)
- 1:   [Butirosin acyl-carrier protein]--L-glutamate ligase [6.2.1.39](0|0) (0|0|0)
- 1:   [Citrate (pro-3S)-lyase] ligase [6.2.1.22](2|0) (2|1|0)
- 1:   o-succinylbenzoate--CoA ligase [6.2.1.26](1|1) (1|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Acyl-CoA N-acyltransferases (Nat)1Inherited
Nucleotidylyl transferase1Inherited
PLP-dependent transferases1Inherited
Class II aaRS and biotin synthetases1Inherited
Glycerol-3-phosphate (1)-acyltransferase1Inherited
Acetyl-CoA synthetase-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Succinyl-CoA synthetase domains1Inherited
Activating enzymes of the ubiquitin-like proteins1Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
CoA-binding domain1Inherited
Acetyl-CoA synthetase-like1Inherited
Succinyl-CoA synthetase, beta-chain, N-terminal domain1Inherited
GABA-aminotransferase-like1Inherited
Ubiquitin activating enzymes (UBA)1Inherited
Succinyl-CoA synthetase domains1Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Glycerol-3-phosphate (1)-acyltransferase1Inherited
PLP-dependent transferases1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
Activating enzymes of the ubiquitin-like proteins1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Nucleotidylyl transferase1Inherited
Class II aaRS and biotin synthetases1Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
Acetyl-CoA synthetase-like1Inherited
Succinyl-CoA synthetase domains1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
69593,56801
  • 69593 - Glycerol-3-phosphate (1)-acyltransferase
  • 56801 - Acetyl-CoA synthetase-like
    		• 1Inherited
    69572,69572
  • 69572 - Activating enzymes of the ubiquitin-like proteins
  • 69572 - Activating enzymes of the ubiquitin-like proteins
    		• 1Inherited
    52210,52210
  • 52210 - Succinyl-CoA synthetase domains
  • 52210 - Succinyl-CoA synthetase domains
    		• 1Inherited
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
    		• 1Inherited
    51735,52210
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 52210 - Succinyl-CoA synthetase domains
    		• 1Inherited
    55729,52374
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 52374 - Nucleotidylyl transferase
    		• 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51735,52210,52210
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 52210 - Succinyl-CoA synthetase domains
  • 52210 - Succinyl-CoA synthetase domains
    		• 1Inherited

    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)
    Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

    Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

    © Copyright 2013 The SUPERFAMILY authors and Julian Gough.