Enzyme Commission (EC): Forming carbon-nitrogen bonds

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: root [root] <7>

+ 1: Ligases [6] <6> (98|123) (97|115|71)

0: Forming carbon-nitrogen bonds [6.3] <5> (59|78) (58|59|38)

- 1: Acid--amino-acid ligases (peptide synthases) [6.3.2] <64> (18|25) (18|18|11)

- 1: Other carbon--nitrogen ligases [6.3.4] <24> (28|31) (27|28|19)

- 1: Acid--ammonia (or amine) ligases (amide synthases) [6.3.1] <20> (8|11) (8|4|1)

- 1: Carbon--nitrogen ligases with glutamine as amido-N-donor [6.3.5] <13> (20|17) (20|19|15)

- 1: Cyclo-ligases [6.3.3] <7> (9|10) (9|6|4)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
SAICAR synthase-like	0	Direct
Methylglyoxal synthase-like	0	Direct
Carbamoyl phosphate synthetase, large subunit connection domain	0	Direct
FGAM synthase PurL, linker domain	0	Direct
Glutamine synthetase, N-terminal domain	0	Direct
CoaB-like	0	Direct
Glutamine synthetase/guanido kinase	0	Direct
Adenine nucleotide alpha hydrolases-like	0	Direct
Argininosuccinate synthetase, C-terminal domain	0	Direct
Amidase signature (AS) enzymes	0	Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain	0	Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	Direct
PurM C-terminal domain-like	0	Direct
Rudiment single hybrid motif	0	Direct
SufE/NifU	0	Direct
CofE-like	0	Direct
PreATP-grasp domain	0	Direct
MurE/MurF N-terminal domain	0	Direct
GMP synthetase C-terminal dimerisation domain	0	Direct
Class I glutamine amidotransferase-like	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
PurM N-terminal domain-like	0	Direct
MurD-like peptide ligases, peptide-binding domain	0	Direct
MurCD N-terminal domain	0	Direct
PurS-like	0	Direct
Glutathione synthetase ATP-binding domain-like	0	Direct
C-terminal domain of transcriptional repressors	0	Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	Direct
MesJ substrate recognition domain-like	0	Direct
MurD-like peptide ligases, catalytic domain	0	Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	0.000003391	Direct
FMN-dependent nitroreductase-like	0.0001146	Direct
PH0987 N-terminal domain-like	0.0001597	Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	0.0004912	Direct
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	0.001128	Inherited
Carbon-nitrogen hydrolase	0.01886	Inherited
ACP-like	0.1197	Inherited
SCOP hierarchy in SUPERFAMILY	0.8607	Inherited
Nucleic acid-binding proteins	1	Inherited
"Winged helix" DNA-binding domain	1	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	Inherited
Metallo-dependent hydrolases	1	Inherited
alpha/beta-Hydrolases	1	Inherited
"Helical backbone" metal receptor	1	Inherited
ClpP/crotonase	1	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	Inherited
Cyclophilin-like	1	Inherited
CoA-dependent acyltransferases	1	Inherited
Nucleotidylyl transferase	1	Inherited
Aminoacid dehydrogenase-like, N-terminal domain	1	Inherited
Actin-like ATPase domain	1	Inherited
Class II aaRS and biotin synthetases	1	Inherited
Acetyl-CoA synthetase-like	1	Inherited
Formyltransferase	1	Inherited
NagB/RpiA/CoA transferase-like	1	Inherited
Composite domain of metallo-dependent hydrolases	1	Inherited
Single hybrid motif	1	Inherited
Aspartate/ornithine carbamoyltransferase	1	Inherited
PheT/TilS domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Lysine biosynthesis enzyme LysX ATP-binding domain	0	Direct
PurS subunit of FGAM synthetase	0	Direct
ATP-binding domain of peptide synthetases	0	Direct
Glutathionylspermidine synthase substrate-binding domain-like	0	Direct
Amidase signature (AS) enzymes	0	Direct
GMP synthetase C-terminal dimerisation domain	0	Direct
PP-loop ATPase	0	Direct
Glutamate-cysteine ligase	0	Direct
D-Alanine ligase N-terminal domain	0	Direct
MurCDEF C-terminal domain	0	Direct
Carbamoyl phosphate synthetase, large subunit connection domain	0	Direct
CoaB-like	0	Direct
MurCD N-terminal domain	0	Direct
N-type ATP pyrophosphatases	0	Direct
PurM N-terminal domain-like	0	Direct
SP1160 C-terminal domain-like	0	Direct
Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain	0	Direct
MurE/MurF N-terminal domain	0	Direct
Class I glutamine amidotransferases (GAT)	0	Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain	0	Direct
Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like	0	Direct
BC C-terminal domain-like	0	Direct
PurM C-terminal domain-like	0	Direct
Glutamine synthetase, N-terminal domain	0	Direct
Eukaryotic glutathione synthetase, substrate-binding domain	0	Direct
Methenyltetrahydrofolate synthetase	0	Direct
Glutamate-cysteine ligase family 2 (GCS2)	0	Direct
Eukaryotic glutathione synthetase ATP-binding domain	0	Direct
Folylpolyglutamate synthetase, C-terminal domain	0	Direct
MurCDEF	0	Direct
PurP ATP-binding domain-like	0	Direct
Glutathionylspermidine synthase ATP-binding domain-like	0	Direct
SAICAR synthase	0	Direct
Monomeric nicotinate phosphoribosyltransferase C-terminal domain	0	Direct
FGAM synthase PurL, PurS-like domain	0	Direct
Prokaryotic glutathione synthetase, N-terminal domain	0	Direct
BC N-terminal domain-like	0	Direct
CHAP domain	0	Direct
MesJ substrate recognition domain-like	0	Direct
Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)	0	Direct
CofE-like	0	Direct
Argininosuccinate synthetase, C-terminal domain	0	Direct
Nitrogenase iron protein-like	0	Direct
Biotin holoenzyme synthetase	0	Direct
Glutamine synthetase catalytic domain	0	Direct
tRNA-Ile-lysidine synthetase, TilS, C-terminal domain	0	Direct
BC ATP-binding domain-like	0	Direct
PurP N-terminal domain-like	0	Direct
Folylpolyglutamate synthetase	0	Direct
Biotin repressor (BirA)	0	Direct
FGAM synthase PurL, linker domain	0	Direct
NadC C-terminal domain-like	0.00000000002175	Direct
NadC N-terminal domain-like	0.00000000006121	Direct
LplA-like	0.00000000339	Direct
Class II glutamine amidotransferases	0.00000001104	Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	0.000003994	Direct
PH0987 N-terminal domain-like	0.00006091	Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases	0.0001282	Direct
PH0987 C-terminal domain-like	0.0001721	Direct
Peptidyl carrier domain	0.0001942	Direct
NADH oxidase/flavin reductase	0.0005653	Direct
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	0.001226	Inherited
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	0.001844	Inherited
Deoxycytidylate deaminase-like	0.3988	Inherited
Hydantoinase (dihydropyrimidinase), catalytic domain	0.4702	Inherited
Biotinyl/lipoyl-carrier proteins and domains	0.9206	Inherited
CoaX-like	1	Inherited
Acetyl-CoA synthetase-like	1	Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase	1	Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	1	Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	1	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	Inherited
Aminoacid dehydrogenase-like, C-terminal domain	1	Inherited
Formyltransferase	1	Inherited
Nucleotide and nucleoside kinases	1	Inherited
Aspartate/ornithine carbamoyltransferase	1	Inherited
Nitrogenase iron-molybdenum protein	1	Inherited
Biotin dependent carboxylase carboxyltransferase domain	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Adenine nucleotide alpha hydrolases-like	0	Direct
Amidase signature (AS) enzymes	0	Direct
Methylglyoxal synthase-like	0	Direct
PreATP-grasp domain	0	Direct
Argininosuccinate synthetase, C-terminal domain	0	Direct
PurS-like	0	Direct
MurCD N-terminal domain	0	Direct
Glutathione synthetase ATP-binding domain-like	0	Direct
MurD-like peptide ligases, peptide-binding domain	0	Direct
Rudiment single hybrid motif	0	Direct
C-terminal domain of transcriptional repressors	0	Direct
Carbamoyl phosphate synthetase, large subunit connection domain	0	Direct
Glutamine synthetase, N-terminal domain	0	Direct
Glutamine synthetase/guanido kinase	0	Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	Direct
FGAM synthase PurL, linker domain	0	Direct
SufE/NifU	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
MurE/MurF N-terminal domain	0	Direct
CofE-like	0	Direct
MesJ substrate recognition domain-like	0	Direct
PurM C-terminal domain-like	0	Direct
SAICAR synthase-like	0	Direct
PurM N-terminal domain-like	0	Direct
MurD-like peptide ligases, catalytic domain	0	Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	Direct
GMP synthetase C-terminal dimerisation domain	0	Direct
CoaB-like	0	Direct
Class I glutamine amidotransferase-like	0	Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain	0	Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	0.000002664	Direct
FMN-dependent nitroreductase-like	0.00009261	Direct
PH0987 N-terminal domain-like	0.0001293	Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	0.0004018	Direct
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	0.0009301	Direct
Carbon-nitrogen hydrolase	0.0161	Inherited
ACP-like	0.1047	Inherited
Single hybrid motif	0.9436	Inherited
CoA-dependent acyltransferases	0.9964	Inherited
"Winged helix" DNA-binding domain	1	Inherited
ClpP/crotonase	1	Inherited
Cyclophilin-like	1	Inherited
NagB/RpiA/CoA transferase-like	1	Inherited
Formyltransferase	1	Inherited
PheT/TilS domain	1	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	Inherited
Metallo-dependent hydrolases	1	Inherited
alpha/beta-Hydrolases	1	Inherited
Actin-like ATPase domain	1	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	Inherited
Composite domain of metallo-dependent hydrolases	1	Inherited
Nucleotidylyl transferase	1	Inherited
"Helical backbone" metal receptor	1	Inherited
Class II aaRS and biotin synthetases	1	Inherited
Nucleic acid-binding proteins	1	Inherited
Aspartate/ornithine carbamoyltransferase	1	Inherited
Acetyl-CoA synthetase-like	1	Inherited
Aminoacid dehydrogenase-like, N-terminal domain	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
51735,53623 51735 - NAD(P)-binding Rossmann-fold domains 53623 - MurD-like peptide ligases, catalytic domain	0	Direct
54001,56059 54001 - Cysteine proteinases 56059 - Glutathione synthetase ATP-binding domain-like	0	Direct
52402,69864 52402 - Adenine nucleotide alpha hydrolases-like 69864 - Argininosuccinate synthetase, C-terminal domain	0	Direct
52021,52317 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain 52317 - Class I glutamine amidotransferase-like	0	Direct
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
82829,56037 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain	0	Direct
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	Direct
56104,52255 56104 - SAICAR synthase-like 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	0	Direct
53623,53244 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	Direct
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain	0	Direct
144010,55469 144010 - CofE-like 55469 - FMN-dependent nitroreductase-like	0	Direct
52335,51556 52335 - Methylglyoxal synthase-like 51556 - Metallo-dependent hydrolases	0	Direct
56042,52317 56042 - PurM C-terminal domain-like 52317 - Class I glutamine amidotransferase-like	0	Direct
56059,52335 56059 - Glutathione synthetase ATP-binding domain-like 52335 - Methylglyoxal synthase-like	0	Direct
52540,52317 52540 - P-loop containing nucleoside triphosphate hydrolases 52317 - Class I glutamine amidotransferase-like	0	Direct
56042,55326 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like	0	Direct
48108,52440 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain	0	Direct
55931,56059 55931 - Glutamine synthetase/guanido kinase 56059 - Glutathione synthetase ATP-binding domain-like	0	Direct
52777,53474 52777 - CoA-dependent acyltransferases 53474 - alpha/beta-Hydrolases	0	Direct
52402,56037 52402 - Adenine nucleotide alpha hydrolases-like 56037 - PheT/TilS domain	0	Direct
56042,53328 56042 - PurM C-terminal domain-like 53328 - Formyltransferase	0	Direct
56235,52402 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases) 52402 - Adenine nucleotide alpha hydrolases-like	0	Direct
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	Direct
63418,53623 63418 - MurE/MurF N-terminal domain 53623 - MurD-like peptide ligases, catalytic domain	0	Direct
51984,53623 51984 - MurCD N-terminal domain 53623 - MurD-like peptide ligases, catalytic domain	0	Direct
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0	Direct
52402,82829 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like	0	Direct
52402,54810 52402 - Adenine nucleotide alpha hydrolases-like 54810 - GMP synthetase C-terminal dimerisation domain	0	Direct
109736,55326 109736 - FGAM synthase PurL, linker domain 55326 - PurM N-terminal domain-like	0	Direct
82697,109736 82697 - PurS-like 109736 - FGAM synthase PurL, linker domain	0	Direct
52317,52402 52317 - Class I glutamine amidotransferase-like 52402 - Adenine nucleotide alpha hydrolases-like	0	Direct
54675,51690 54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like	0	Direct
56317,52402 56317 - Carbon-nitrogen hydrolase 52402 - Adenine nucleotide alpha hydrolases-like	0	Direct
56059,53623 56059 - Glutathione synthetase ATP-binding domain-like 53623 - MurD-like peptide ligases, catalytic domain	0	Direct
54368,55931 54368 - Glutamine synthetase, N-terminal domain 55931 - Glutamine synthetase/guanido kinase	0	Direct
50891,160467 50891 - Cyclophilin-like 160467 - PH0987 N-terminal domain-like	0	Direct
52507,102645 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD 102645 - CoaB-like	0	Direct
51246,55326 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like	0	Direct
-7,52317 -7 - CATH 52317 - Class I glutamine amidotransferase-like	0	Direct
53244,52440 53244 - MurD-like peptide ligases, peptide-binding domain 52440 - PreATP-grasp domain	0	Direct
54810,54810 54810 - GMP synthetase C-terminal dimerisation domain 54810 - GMP synthetase C-terminal dimerisation domain	0	Direct
56037,53271 56037 - PheT/TilS domain 53271 - PRTase-like	0	Direct
56059,52440 56059 - Glutathione synthetase ATP-binding domain-like 52440 - PreATP-grasp domain	0	Direct
56059,48108 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain	0	Direct
52317,52440 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain	0	Direct
55681,82649 55681 - Class II aaRS and biotin synthetases 82649 - SufE/NifU	0	Direct
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors	0	Direct
52540,-7 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH	0.0000000284	Direct
52777,56801 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like	0.000006202	Direct
160467,50891 160467 - PH0987 N-terminal domain-like 50891 - Cyclophilin-like	0.0001293	Direct
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases	0.0001913	Direct
55116,55116 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase. 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.	0.0009301	Direct
46785,55681 46785 - "Winged helix" DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0.01528	Inherited
56801,47336 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like	0.07239	Inherited
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0.163	Inherited
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	1	Inherited
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	1	Inherited
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	1	Inherited
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
109736,55326,56042 109736 - FGAM synthase PurL, linker domain 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	Direct
55681,50037,53067 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain	0	Direct
53623,53244,52440 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain 52440 - PreATP-grasp domain	0	Direct
82697,109736,55326 82697 - PurS-like 109736 - FGAM synthase PurL, linker domain 55326 - PurM N-terminal domain-like	0	Direct
55326,56042,53328 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like 53328 - Formyltransferase	0	Direct
48108,52440,56059 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0	Direct
56059,51246,55326 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like	0	Direct
51984,53623,53244 51984 - MurCD N-terminal domain 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	Direct
50891,160467,50891 50891 - Cyclophilin-like 160467 - PH0987 N-terminal domain-like 50891 - Cyclophilin-like	0	Direct
52317,52440,56059 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0	Direct
55326,56042,52317 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like 52317 - Class I glutamine amidotransferase-like	0	Direct
55326,56042,55326 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like	0	Direct
52317,52402,54810 52317 - Class I glutamine amidotransferase-like 52402 - Adenine nucleotide alpha hydrolases-like 54810 - GMP synthetase C-terminal dimerisation domain	0	Direct
50037,53067,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0	Direct
52440,56059,48108 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain	0	Direct
63418,53623,53244 63418 - MurE/MurF N-terminal domain 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	Direct
52335,51556,51338 52335 - Methylglyoxal synthase-like 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	Direct
52021,52317,52440 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain	0	Direct
56059,52335,51556 56059 - Glutathione synthetase ATP-binding domain-like 52335 - Methylglyoxal synthase-like 51556 - Metallo-dependent hydrolases	0	Direct
52440,56059,52335 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 52335 - Methylglyoxal synthase-like	0	Direct
56059,53623,53244 56059 - Glutathione synthetase ATP-binding domain-like 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	Direct
52777,52777,53474 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases 53474 - alpha/beta-Hydrolases	0	Direct
56042,55326,56042 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	Direct
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	Direct
46785,55681,50037 46785 - "Winged helix" DNA-binding domain 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors	0	Direct
51246,55326,56042 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	Direct
53244,52440,56059 53244 - MurD-like peptide ligases, peptide-binding domain 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0	Direct
54001,56059,52440 54001 - Cysteine proteinases 56059 - Glutathione synthetase ATP-binding domain-like 52440 - PreATP-grasp domain	0	Direct
56059,48108,52440 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain	0	Direct
82829,56037,53271 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain 53271 - PRTase-like	0	Direct
52402,54810,54810 52402 - Adenine nucleotide alpha hydrolases-like 54810 - GMP synthetase C-terminal dimerisation domain 54810 - GMP synthetase C-terminal dimerisation domain	0	Direct
52402,82829,56037 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain	0	Direct
51735,53623,53244 51735 - NAD(P)-binding Rossmann-fold domains 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	Direct
52540,-7,52317 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH 52317 - Class I glutamine amidotransferase-like	0	Direct
52777,52777,56801 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like	0.000001986	Direct
52777,56801,47336 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like	0.000004699	Direct
56801,47336,52777 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like 52777 - CoA-dependent acyltransferases	0.00001849	Direct
47336,52777,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0.0001913	Direct

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Enzyme Commission (EC): Forming carbon-nitrogen bonds

Superfamily

Family

Supra-domain (including individual superfamily)