Enzyme Commission (EC): Other carbon--nitrogen ligases

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: root [root] <7>

+ + 2: Ligases [6] <6> (98|123) (97|115|71)

+ 1: Forming carbon-nitrogen bonds [6.3] <5> (59|78) (58|59|38)

0: Other carbon--nitrogen ligases [6.3.4] <24> (28|31) (27|28|19)

- 1: 5-(carboxyamino)imidazole ribonucleotide synthase [6.3.4.18] (3|3) (3|2|1)

- 1: 7-cyano-7-deazaguanine synthase [6.3.4.20] (1|1) (1|1|0)

- 1: Adenylosuccinate synthase [6.3.4.4] (1|1) (1|0|0)

- 1: Argininosuccinate synthase [6.3.4.5] (2|2) (2|1|0)

- 1: Biotin carboxylase [6.3.4.14] (5|5) (5|2|1)

- 1: Biotin--[biotin carboxyl-carrier protein] ligase [6.3.4.15] (4|3) (4|4|3)

- 1: Biotin--[methylcrotonoyl-CoA-carboxylase] ligase [6.3.4.11] (1|1) (1|0|0)

- 1: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase [6.3.4.9] (1|1) (1|0|0)

- 1: Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase [6.3.4.10] (1|1) (1|0|0)

- 1: CTP synthase (glutamine hydrolyzing) [6.3.4.2] (3|2) (2|3|1)

- 1: Carbamoyl-phosphate synthase (ammonia) [6.3.4.16] (5|4) (5|6|6)

- 1: Formate--dihydrofolate ligase [6.3.4.17] (0|0) (0|0|0)

- 1: Formate--phosphoribosylaminoimidazolecarboxamide ligase [6.3.4.23] (2|2) (2|1|0)

- 1: Formate--tetrahydrofolate ligase [6.3.4.3] (2|3) (2|1|0)

- 1: Glutamate--methylamine ligase [6.3.4.12] (0|0) (0|0|0)

- 1: Imidazoleacetate--phosphoribosyldiphosphate ligase [6.3.4.8] (0|0) (0|0|0)

- 1: Nicotinate phosphoribosyltransferase [6.3.4.21] (2|4) (2|1|0)

- 1: Phosphoribosylamine--glycine ligase [6.3.4.13] (6|6) (6|6|6)

- 1: Ribose-5-phosphate--ammonia ligase [6.3.4.7] (0|0) (0|0|0)

- 1: Transferred entry: 6.3.5.2 [6.3.4.1] (0|0) (0|0|0)

- 1: Tyramine--L-glutamate ligase [6.3.4.24] (0|0) (0|0|0)

- 1: Urea carboxylase [6.3.4.6] (6|6) (6|4|2)

- 1: tRNA(Ile)(2)-agmatinylcytidine synthase [6.3.4.22] (1|0) (1|0|0)

- 1: tRNA(Ile)-lysidine synthetase [6.3.4.19] (3|4) (3|4|2)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Adenine nucleotide alpha hydrolases-like	0	Direct
Argininosuccinate synthetase, C-terminal domain	0	Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	Direct
Rudiment single hybrid motif	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
C-terminal domain of transcriptional repressors	0	Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	Direct
MesJ substrate recognition domain-like	0	Direct
PheT/TilS domain	0	Direct
Single hybrid motif	0.00000000001264	Direct
PH0987 N-terminal domain-like	0.000002184	Direct
Class I glutamine amidotransferase-like	0.002163	Inherited
SCOP hierarchy in SUPERFAMILY	0.02943	Inherited
Cyclophilin-like	0.8256	Inherited
Nucleic acid-binding proteins	1	Inherited
"Winged helix" DNA-binding domain	1	Inherited
Methylglyoxal synthase-like	1	Inherited
Carbamoyl phosphate synthetase, large subunit connection domain	1	Inherited
ClpP/crotonase	1	Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain	1	Inherited
Aminoacid dehydrogenase-like, N-terminal domain	1	Inherited
Actin-like ATPase domain	1	Inherited
Class II aaRS and biotin synthetases	1	Inherited
PurM C-terminal domain-like	1	Inherited
PreATP-grasp domain	1	Inherited
Formyltransferase	1	Inherited
PurM N-terminal domain-like	1	Inherited
Glutathione synthetase ATP-binding domain-like	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
PP-loop ATPase	0	Direct
N-type ATP pyrophosphatases	0	Direct
Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like	0	Direct
NadC N-terminal domain-like	0	Direct
BC C-terminal domain-like	0	Direct
PurP ATP-binding domain-like	0	Direct
Monomeric nicotinate phosphoribosyltransferase C-terminal domain	0	Direct
MesJ substrate recognition domain-like	0	Direct
Argininosuccinate synthetase, C-terminal domain	0	Direct
Nitrogenase iron protein-like	0	Direct
NadC C-terminal domain-like	0	Direct
Biotin holoenzyme synthetase	0	Direct
tRNA-Ile-lysidine synthetase, TilS, C-terminal domain	0	Direct
PurP N-terminal domain-like	0	Direct
Biotin repressor (BirA)	0	Direct
Biotinyl/lipoyl-carrier proteins and domains	0.00000000003132	Direct
PH0987 N-terminal domain-like	0.000000823	Direct
PH0987 C-terminal domain-like	0.000002401	Direct
Class I glutamine amidotransferases (GAT)	0.0001674	Direct
BC ATP-binding domain-like	0.0003695	Direct
BC N-terminal domain-like	0.0008431	Direct
Deoxycytidylate deaminase-like	0.01212	Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase	0.4595	Inherited
Biotin dependent carboxylase carboxyltransferase domain	0.7018	Inherited
CoaX-like	0.9019	Inherited
Carbamoyl phosphate synthetase, large subunit connection domain	1	Inherited
PurM N-terminal domain-like	1	Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain	1	Inherited
PurM C-terminal domain-like	1	Inherited
Aminoacid dehydrogenase-like, C-terminal domain	1	Inherited
Formyltransferase	1	Inherited

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Adenine nucleotide alpha hydrolases-like	0	Direct
Argininosuccinate synthetase, C-terminal domain	0	Direct
PheT/TilS domain	0	Direct
Rudiment single hybrid motif	0	Direct
C-terminal domain of transcriptional repressors	0	Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
MesJ substrate recognition domain-like	0	Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	Direct
Single hybrid motif	0.000000000009154	Direct
PH0987 N-terminal domain-like	0.000001713	Direct
Class I glutamine amidotransferase-like	0.0018	Inherited
Cyclophilin-like	0.7604	Inherited
Formyltransferase	0.9552	Inherited
"Winged helix" DNA-binding domain	1	Inherited
Methylglyoxal synthase-like	1	Inherited
PreATP-grasp domain	1	Inherited
ClpP/crotonase	1	Inherited
Glutathione synthetase ATP-binding domain-like	1	Inherited
Carbamoyl phosphate synthetase, large subunit connection domain	1	Inherited
Actin-like ATPase domain	1	Inherited
PurM C-terminal domain-like	1	Inherited
Class II aaRS and biotin synthetases	1	Inherited
PurM N-terminal domain-like	1	Inherited
Nucleic acid-binding proteins	1	Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain	1	Inherited
Aminoacid dehydrogenase-like, N-terminal domain	1	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52402,69864 52402 - Adenine nucleotide alpha hydrolases-like 69864 - Argininosuccinate synthetase, C-terminal domain	0	Direct
82829,56037 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain	0	Direct
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain	0	Direct
52540,52317 52540 - P-loop containing nucleoside triphosphate hydrolases 52317 - Class I glutamine amidotransferase-like	0	Direct
52402,56037 52402 - Adenine nucleotide alpha hydrolases-like 56037 - PheT/TilS domain	0	Direct
56042,53328 56042 - PurM C-terminal domain-like 53328 - Formyltransferase	0	Direct
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	Direct
52402,82829 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like	0	Direct
54675,51690 54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like	0	Direct
50891,160467 50891 - Cyclophilin-like 160467 - PH0987 N-terminal domain-like	0	Direct
51246,55326 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like	0	Direct
-7,52317 -7 - CATH 52317 - Class I glutamine amidotransferase-like	0	Direct
56037,53271 56037 - PheT/TilS domain 53271 - PRTase-like	0	Direct
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors	0	Direct
52540,-7 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH	0.00000000003894	Direct
46785,55681 46785 - "Winged helix" DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0.000000002172	Direct
160467,50891 160467 - PH0987 N-terminal domain-like 50891 - Cyclophilin-like	0.000001713	Direct
52317,52440 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain	0.5567	Inherited
52021,52317 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain 52317 - Class I glutamine amidotransferase-like	1	Inherited
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	1	Inherited
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	1	Inherited
56059,52335 56059 - Glutathione synthetase ATP-binding domain-like 52335 - Methylglyoxal synthase-like	1	Inherited
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	1	Inherited
56042,55326 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like	1	Inherited
48108,52440 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain	1	Inherited
56235,52402 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases) 52402 - Adenine nucleotide alpha hydrolases-like	1	Inherited
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	1	Inherited
56059,48108 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain	1	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55681,50037,53067 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain	0	Direct
55326,56042,53328 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like 53328 - Formyltransferase	0	Direct
56059,51246,55326 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like	0	Direct
50891,160467,50891 50891 - Cyclophilin-like 160467 - PH0987 N-terminal domain-like 50891 - Cyclophilin-like	0	Direct
50037,53067,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0	Direct
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	Direct
46785,55681,50037 46785 - "Winged helix" DNA-binding domain 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors	0	Direct
51246,55326,56042 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	Direct
82829,56037,53271 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain 53271 - PRTase-like	0	Direct
52402,82829,56037 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain	0	Direct
52540,-7,52317 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH 52317 - Class I glutamine amidotransferase-like	0	Direct
52317,52440,56059 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0.5567	Inherited
52021,52317,52440 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain	0.5567	Inherited
48108,52440,56059 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	1	Inherited
55326,56042,55326 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like	1	Inherited
52440,56059,48108 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain	1	Inherited
52440,56059,52335 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 52335 - Methylglyoxal synthase-like	1	Inherited
56042,55326,56042 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	1	Inherited
56059,48108,52440 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain	1	Inherited

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Enzyme Commission (EC): Other carbon--nitrogen ligases

Superfamily

Family

Supra-domain (including individual superfamily)