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Fly Anatomy (FA): tagma
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this FA term (Not in SDFA)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (SDFA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| Dachshund-homology domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| N-acetyl transferase, NAT | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Homeodomain | 0.000000000001891 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.00000006722 | DIRECT |
| Classic zinc finger, C2H2 | 0.001127 | INHERITED FROM: adult tagma || adult mesothoracic segment || embryonic/larval head sensillum || adult thorax || thorax |
| Protein kinases, catalytic subunit | 0.003294 | INHERITED FROM: photoreceptor cell R8 of pale ommatidium |
| Fibronectin type III | 0.005253 | INHERITED FROM: LN period neuron || lobe system of adult mushroom body || larval tagma || LNv neuron || procephalic segment || larval abdomen || s-LNv neuron |
| SH2 domain | 0.03102 | INHERITED FROM: photoreceptor cell R7 || head sensillum || ommatidium |
| I set domains | 0.03102 | INHERITED FROM: head segment || lobe system of adult mushroom body || adult cerebral ganglion || LNv neuron || procephalic segment || adult brain || larval abdomen || s-LNv neuron || adult head segment |
| Laminin G-like module | 0.03154 | INHERITED FROM: photoreceptor cell R4 || procephalic segment |
| Nuclear receptor ligand-binding domain | 0.03474 | INHERITED FROM: mushroom body gamma-lobe || protocerebrum || procephalic segment |
| Nuclear receptor | 0.05321 | INHERITED FROM: mushroom body gamma-lobe || abdominal neuromere || larval abdominal neuromere |
| Histone lysine methyltransferases | 0.08272 | INHERITED FROM: dorsal thoracic disc || adult metathoracic segment || haltere || metathoracic leg |
| HMG-box | 0.08582 | INHERITED FROM: adult mesothoracic segment || adult external thorax || adult thorax || adult thoracic segment || wing |
| Calponin-homology domain, CH-domain | 0.09367 | INHERITED FROM: indirect flight muscle || abdominal segmental nerve || flight muscle |
| Cytochrome P450 | 0.09687 | INHERITED FROM: embryonic head |
| Transforming growth factor (TGF)-beta | 0.113 | INHERITED FROM: embryonic/larval posterior spiracle || stigmatophore |
| Plexin repeat | 0.1543 | INHERITED FROM: abdomen || larval abdominal segment || abdominal segment || abdominal nerve || larval abdomen |
| Ngr ectodomain-like | 0.1704 | INHERITED FROM: intersegmental nerve branch ISNb of A1-7 || intersegmental nerve of A1-7 || abdominal intersegmental nerve |
| SMAD domain | 0.2104 | INHERITED FROM: wing vein || larval thoracic segment || dorsal thoracic disc || larval mesothoracic segment || wing blade || abdominal segment || larval thorax || wing disc |
| BTB/POZ domain | 0.2741 | INHERITED FROM: adult antennal segment || prothoracic tarsal segment || adult abdominal segment |
| SAM (sterile alpha motif) domain | 0.2785 | INHERITED FROM: prothoracic leg || adult metathoracic segment || sex comb || metatarsus of male prothoracic leg || prothoracic metatarsus || adult prothoracic segment || prothoracic tarsal segment || mesothoracic leg || adult abdominal segment 4 || metatarsus |
| Cadherin | 0.2785 | INHERITED FROM: photoreceptor cell R4 || wing hair || outer photoreceptor cell |
| Choline/Carnitine O-acyltransferase | 0.2872 | INHERITED FROM: skeletal muscle of mesothorax || flight muscle || skeletal muscle of thorax |
| EGF-type module | 0.3036 | INHERITED FROM: adult external head || wing blade || adult antennal segment |
| Growth factor receptor domain | 0.382 | INHERITED FROM: ocellar triangle || ocellus || tibia |
| PLC-like (P variant) | 0.5514 | INHERITED FROM: mesothoracic tergum |
| G proteins | 1 | INHERITED FROM: wing hair |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| ets domain | 0 | Direct |
| FHA domain | 0 | Direct |
| Paired domain | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| Dachshund-homology domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| N-acetyl transferase, NAT | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| VHS domain | 0 | Direct |
| ARID domain | 0 | Direct |
| ZZ domain | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Sema domain | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Laminin-type module | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| SAP domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Pepsin-like | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Homeodomain | 0.000000000001891 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.00000006722 | Direct |
| Classic zinc finger, C2H2 | 0.001127 | Inherited |
| Protein kinases, catalytic subunit | 0.003294 | Inherited |
| Fibronectin type III | 0.005253 | Inherited |
| SH2 domain | 0.03102 | Inherited |
| I set domains | 0.03102 | Inherited |
| Laminin G-like module | 0.03154 | Inherited |
| Nuclear receptor ligand-binding domain | 0.03474 | Inherited |
| Nuclear receptor | 0.05321 | Inherited |
| Histone lysine methyltransferases | 0.08272 | Inherited |
| HMG-box | 0.08582 | Inherited |
| Calponin-homology domain, CH-domain | 0.09367 | Inherited |
| Cytochrome P450 | 0.09687 | Inherited |
| Transforming growth factor (TGF)-beta | 0.113 | Inherited |
| Plexin repeat | 0.1543 | Inherited |
| Ngr ectodomain-like | 0.1704 | Inherited |
| SMAD domain | 0.2104 | Inherited |
| BTB/POZ domain | 0.2741 | Inherited |
| SAM (sterile alpha motif) domain | 0.2785 | Inherited |
| Cadherin | 0.2785 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.2872 | Inherited |
| EGF-type module | 0.3036 | Inherited |
| Growth factor receptor domain | 0.382 | Inherited |
| PLC-like (P variant) | 0.5514 | Inherited |
| G proteins | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.0000008513 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01798 | INHERITED FROM: adult brain || adult cerebral ganglion || LNv neuron || larval abdomen || adult head segment || lobe system of adult mushroom body || LN period neuron || s-LNv neuron || procephalic segment || head segment |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.01829 | INHERITED FROM: LNv neuron || lobe system of adult mushroom body || adult antennal lobe glomerulus || LN period neuron || s-LNv neuron || adult antennal lobe |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.104 | INHERITED FROM: abdominal neuron || lamina || larval abdomen |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.14 | INHERITED FROM: joint || frons || postfrons || ocellus || eye photoreceptor cell stalk || intersegmental nerve branch ISNb of A1-7 || wing blade dorsal compartment || secondary pigment cell || tertiary pigment cell |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1443 | INHERITED FROM: leg || joint || wing vein || adult thoracic sensillum || photoreceptor cell R7 || abdomen || interommatidial bristle || wing blade dorsal compartment || scutum || mesothoracic bristle || inner photoreceptor cell || adult mesothoracic sensillum |
81296,81296
81296 - E set domains
81296 - E set domains | 0.1995 | INHERITED FROM: abdominal intersegmental nerve || abdominal segmental nerve || abdominal nerve |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.2606 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell || wing hair |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.2606 | INHERITED FROM: adult protocerebrum || adult labral segment |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.2756 | INHERITED FROM: larval abdomen || larval abdominal segment || abdominal segmental nerve || abdominal nerve |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.2756 | INHERITED FROM: flight muscle || skeletal muscle of thorax || skeletal muscle of mesothorax |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3228 | INHERITED FROM: dorsal thoracic disc posterior compartment || wing disc posterior compartment || bristle of mesothoracic tergum |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.0000008513 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01798 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.01829 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.104 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.14 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1443 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.1995 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.2606 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.2606 | Inherited |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.2756 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.2756 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3228 | Inherited |
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.000182 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.01181 | INHERITED FROM: LNv neuron || lobe system of adult mushroom body || adult antennal lobe glomerulus || LN period neuron || s-LNv neuron || adult antennal lobe |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01942 | INHERITED FROM: joint || frons || postfrons || adult head sensillum || ocellus || eye photoreceptor cell stalk || ocellar triangle || adult external head || wing blade dorsal compartment || larval tagma || abdominal segment || secondary pigment cell || photoreceptor cell R1 || photoreceptor cell R6 || tertiary pigment cell |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.09815 | INHERITED FROM: adult brain || LNv neuron || lobe system of adult mushroom body || s-LNv neuron || procephalic segment || head segment |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.2606 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell || wing hair |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.000182 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.01181 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01942 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.09815 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.2606 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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