Fly Anatomy (FA): embryonic/larval nervous system

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)

Shortest distance to current term (+ for parents, - for children) FA term [FA ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + + 6: anatomical entity [FBbt:99999999] <4>

+ + + + + 5: material anatomical entity [FBbt:00007016] <6> (240|245) (239|100|32)

+ + + + 4: anatomical structure [FBbt:00007001] <6> (240|245) (239|100|32)

+ + + 3: multicellular structure [FBbt:00100313] <96> (235|240) (235|100|31)

+ + 2: organ system [FBbt:00004856] <9> (142|161) (143|78|27)

+ + 2: organism [FBbt:00000001] <12> (200|210) (201|92|30)

+ 1: nervous system [FBbt:00005093] <13> (43|57) (46|26|12)

+ 1: larva [FBbt:00001727] <23> (83|103) (88|49|20)

0: embryonic/larval nervous system [FBbt:00001911] <14> (37|47) (40|24|11)

- 1: neuron [FBbt:00005106] <238> (30|35) (31|16|8)

- 1: embryonic/larval neuron [FBbt:00001446] <232> (4|10) (4|2|0)

- 1: embryonic/larval central nervous system [FBbt:00001919] <36> (9|13) (9|3|2)

- 1: neuron projection bundle of ventral nerve cord [FBbt:00047551] <18> (4|3) (4|3|3)

- 1: embryonic/larval subesophageal ganglion [FBbt:00100138] <14> (1|1) (1|0|0)

- 1: nervous system of embryonic/larval thorax [FBbt:00007485] <13> (1|0) (1|1|0)

- 1: embryonic/larval peripheral nervous system [FBbt:00005893] <9> (5|7) (7|7|2)

- 1: nervous system of embryonic/larval abdomen [FBbt:00007486] <9> (0|0) (0|0|0)

- 1: larval neuromere [FBbt:00001912] <8> (2|3) (3|1|0)

- 1: embryonic/larval glial cell [FBbt:00001251] <3> (1|2) (1|0|0)

- 1: larval prothoracic accessory nerve [FBbt:00048501] (0|0) (0|0|0)

- 1: nervus corporis cardiaci I [FBbt:00001721] (0|0) (0|0|0)

- 1: nervus corporis cardiaci II [FBbt:00110626] (0|0) (0|0|0)

- 1: nervus corporis cardiaci III [FBbt:00110627] (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
lambda repressor-like DNA-binding domains	0	Direct
TIMP-like	0	Direct
L27 domain	0	Direct
Mob1/phocein	0	Direct
Sema domain	0	Direct
Periplasmic binding protein-like I	0	Direct
Frizzled cysteine-rich domain	0	Direct
Arginase/deacetylase	0	Direct
SMAD MH1 domain	0	Direct
Integrin domains	0	Direct
Plexin repeat	0	Direct
Metal cation-transporting ATPase, ATP-binding domain N	0	Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	Direct
Homeodomain-like	0.01479	Inherited
Immunoglobulin	0.02043	Inherited
SH2 domain	0.02981	Inherited
Fibronectin type III	0.0541	Inherited
Cap-Gly domain	0.0941	Inherited
Transducin (alpha subunit), insertion domain	0.1017	Inherited
Snake toxin-like	0.1017	Inherited
Caspase-like	0.1017	Inherited
Ankyrin repeat	0.1037	Inherited
dsRNA-binding domain-like	0.1166	Inherited
BAR/IMD domain-like	0.1166	Inherited
HAD-like	0.141	Inherited
HLH, helix-loop-helix DNA-binding domain	0.1419	Inherited
Growth factor receptor domain	0.1441	Inherited
EGF/Laminin	0.1543	Inherited
Orange domain-like	0.1639	Inherited
Nuclear receptor ligand-binding domain	0.1757	Inherited
Spectrin repeat	0.1791	Inherited
Cadherin-like	0.2403	Inherited
L domain-like	0.2496	Inherited
(Phosphotyrosine protein) phosphatases II	0.3016	Inherited
Toll/Interleukin receptor TIR domain	0.3274	Inherited
Cytochrome P450	0.4337	Inherited
beta-beta-alpha zinc fingers	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
RNase III catalytic domain-like	0	Direct
Eps15 homology domain (EH domain)	0	Direct
Single strand DNA-binding domain, SSB	0	Direct
Metal cation-transporting ATPase, ATP-binding domain N	0	Direct
Frizzled cysteine-rich domain	0	Direct
SMAD MH1 domain	0	Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	Direct
Diacylglycerol kinase-like	0	Direct
Plexin repeat	0	Direct
Extracellular domain of cell surface receptors	0	Direct
Histone deacetylase, HDAC	0	Direct
Sema domain	0	Direct
L27 domain	0	Direct
EF-hand modules in multidomain proteins	0	Direct
POU-specific domain	0	Direct
Tetramerization domain of potassium channels	0	Direct
Mob1/phocein	0	Direct
L-arabinose binding protein-like	0	Direct
Integrin domains	0	Direct
Phoshoinositide 3-kinase (PI3K) helical domain	0	Direct
Homeodomain	0.0068	Inherited
Laminin G-like module	0.01846	Inherited
SH2 domain	0.03394	Inherited
Fibronectin type III	0.05915	Inherited
Transforming growth factor (TGF)-beta	0.06229	Inherited
Cap-Gly domain	0.08679	Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases	0.08906	Inherited
Transducin (alpha subunit), insertion domain	0.09332	Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.09332	Inherited
Protein kinases, catalytic subunit	0.09503	Inherited
I set domains	0.1102	Inherited
Ankyrin repeat	0.1129	Inherited
Paired domain	0.1235	Inherited
Calponin-homology domain, CH-domain	0.1272	Inherited
Caspase catalytic domain	0.1374	Inherited
Spectrin repeat	0.17	Inherited
PLC-like (P variant)	0.17	Inherited
HLH, helix-loop-helix DNA-binding domain	0.1714	Inherited
Nuclear receptor ligand-binding domain	0.1839	Inherited
Hairy Orange domain	0.2388	Inherited
Nuclear receptor	0.2465	Inherited
Toll/Interleukin receptor TIR domain	0.3147	Inherited
Cadherin	0.3406	Inherited
Ngr ectodomain-like	0.3937	Inherited
Cytochrome P450	0.4418	Inherited
Forkhead DNA-binding domain	0.554	Inherited
Ubiquitin-related	0.6669	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Metal cation-transporting ATPase, ATP-binding domain N	0	Direct
SMAD MH1 domain	0	Direct
Plexin repeat	0	Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	Direct
Arginase/deacetylase	0	Direct
Frizzled cysteine-rich domain	0	Direct
Periplasmic binding protein-like I	0	Direct
TIMP-like	0	Direct
L27 domain	0	Direct
Sema domain	0	Direct
lambda repressor-like DNA-binding domains	0	Direct
Mob1/phocein	0	Direct
Integrin domains	0	Direct
Homeodomain-like	0.01118	Inherited
Immunoglobulin	0.0157	Inherited
SH2 domain	0.02325	Inherited
Fibronectin type III	0.04335	Inherited
Protein kinase-like (PK-like)	0.04558	Inherited
Cap-Gly domain	0.0781	Inherited
Transducin (alpha subunit), insertion domain	0.08488	Inherited
Snake toxin-like	0.08488	Inherited
Caspase-like	0.08488	Inherited
Ankyrin repeat	0.08663	Inherited
dsRNA-binding domain-like	0.09835	Inherited
BAR/IMD domain-like	0.09835	Inherited
Calponin-homology domain, CH-domain	0.1033	Inherited
HAD-like	0.1198	Inherited
HLH, helix-loop-helix DNA-binding domain	0.1206	Inherited
Growth factor receptor domain	0.1226	Inherited
EGF/Laminin	0.1319	Inherited
Orange domain-like	0.1408	Inherited
Nuclear receptor ligand-binding domain	0.152	Inherited
Spectrin repeat	0.1551	Inherited
Cadherin-like	0.212	Inherited
L domain-like	0.2209	Inherited
(Phosphotyrosine protein) phosphatases II	0.271	Inherited
Toll/Interleukin receptor TIR domain	0.2957	Inherited
Cytochrome P450	0.4013	Inherited
GTPase activation domain, GAP	0.542	Inherited
beta-beta-alpha zinc fingers	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0	Direct
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	Direct
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0	Direct
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	Direct
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like	0	Direct
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	Direct
81296,81296 81296 - E set domains 81296 - E set domains	0	Direct
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0	Direct
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.03375	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.07338	Inherited
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.0781	Inherited
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0.0781	Inherited
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.08488	Inherited
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.1101	Inherited
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.1282	Inherited
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0.1408	Inherited
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.1551	Inherited
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1574	Inherited
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II	0.1944	Inherited
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.1944	Inherited
47473,47473 47473 - EF-hand 47473 - EF-hand	0.2044	Inherited
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.2957	Inherited
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0.3096	Inherited
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.7516	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	Direct
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0	Direct
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains	0	Direct
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0544	Inherited
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.08488	Inherited
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1612	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1963	Inherited
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.3096	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.4045	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Fly Anatomy (FA): embryonic/larval nervous system

Superfamily

Family

Supra-domain (including individual superfamily)