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Fly Anatomy (FA): organ system
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this FA term (Not in SDFA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| L30e-like | 0 | DIRECT |
| Bromodomain | 0 | DIRECT |
| B-box zinc-binding domain | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| BAR/IMD domain-like | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| TIMP-like | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| C-type lectin-like | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| PX domain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Serpins | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| TRAF domain-like | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Periplasmic binding protein-like I | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| TATA-box binding protein-like | 0 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Clavaminate synthase-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Nucleotide-diphospho-sugar transferases | 0 | DIRECT |
| HMG-box | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| DBL homology domain (DH-domain) | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| (Trans)glycosidases | 0 | DIRECT |
| EGF/Laminin | 0 | DIRECT |
| Ypt/Rab-GAP domain of gyp1p | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| Snake toxin-like | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| FKBP-like | 0 | DIRECT |
| NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
| Multidrug resistance efflux transporter EmrE | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| PDZ domain-like | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Concanavalin A-like lectins/glucanases | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0 | DIRECT |
| Glycerol-3-phosphate (1)-acyltransferase | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| Homeodomain-like | 0.00001778 | DIRECT |
| beta-beta-alpha zinc fingers | 0.0003121 | DIRECT |
| PH domain-like | 0.004664 | INHERITED FROM: embryonic foregut |
| Fibronectin type III | 0.02856 | INHERITED FROM: tract neuropil || leg taste bristle chemosensory neuron || adult pacemaker neuron || neuron projection bundle || pacemaker neuron || LNv neuron || commissure || synaptic neuropil || neuron projection bundle of ventral nerve cord || s-LNv neuron || LN period neuron || lobe system of adult mushroom body |
| L domain-like | 0.03875 | INHERITED FROM: BAlc1 lineage neuron |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.05873 | INHERITED FROM: integumentary system || adult integumentary system || region of integument || adult external thorax |
| SH2 domain | 0.1224 | INHERITED FROM: cyst progenitor cell || photoreceptor cell R7 || egg chamber || adult peripheral nervous system || embryonic/larval integumentary system || photoreceptor cell || midline crossing tract || rhabdomeric photoreceptor cell || histaminergic neuron || ommatidium || adult optic lobe neuron |
| POZ domain | 0.1305 | INHERITED FROM: terminal filament |
| Protein kinase-like (PK-like) | 0.151 | INHERITED FROM: embryonic/larval integumentary system || synaptic neuropil || somatic cell of ovariole || intestinal stem cell || ovariole || pupal/adult digestive system || nervous system |
| Immunoglobulin | 0.1863 | INHERITED FROM: tract neuropil || leg taste bristle chemosensory neuron || abdominal nerve || adult pacemaker neuron || central nervous system || neuron projection bundle || pacemaker neuron || LNv neuron || commissure || nerve || antennal lobe glomerulus || synaptic neuropil || adult brain || neuron projection bundle of ventral nerve cord || LN period neuron || abdominal segmental nerve || neuropil glial sheath || connective || longitudinal muscle || lobe system of adult mushroom body || nervous system |
| Growth factor receptor domain | 0.2142 | INHERITED FROM: embryonic hemocoel || vMP2 neuron || photoreceptor cell R7 || wing vein L2 || cortical zone of lymph gland primary lobe || embryonic/larval tracheal system || adult heart || proventriculus || ocellus || germinal proliferation center hub || adult circulatory system || surface associated glial cell || somatic cell of testis || tracheal system || dorsal acute muscle || endocuticle || germinal proliferation center || ventral nervous system || GABAergic neuron || head mesoderm derived embryonic hemocyte || embryonic hemocyte || adult dorsal vessel || ocellar triangle || ventral midline || integumentary specialisation || primary lobe of embryonic/larval lymph gland || RP2sib neuron || dMP2 neuron || embryonic/larval midline of ventral nerve cord || hindgut || embryonic fiber tract |
| p53-like transcription factors | 0.2354 | INHERITED FROM: embryonic hemocoel || integumentary system || tagmatic subdivision of integument || head mesoderm derived embryonic hemocyte || embryonic hemocyte || embryonic/larval circulatory system || adult external thorax || mesothoracic tergum |
| Cysteine-rich domain | 0.2587 | INHERITED FROM: embryonic/larval integumentary system |
| Cystine-knot cytokines | 0.2587 | INHERITED FROM: embryonic/larval spiracle || stigmatophore || embryonic/larval posterior spiracle |
| Calponin-homology domain, CH-domain | 0.2587 | INHERITED FROM: indirect flight muscle || flight muscle |
| Ankyrin repeat | 0.2803 | INHERITED FROM: Johnston organ neuron |
| HAD-like | 0.2841 | INHERITED FROM: rhabdomere of eye photoreceptor cell |
| E set domains | 0.2906 | INHERITED FROM: embryonic hemocoel || head mesoderm derived embryonic hemocyte || embryonic hemocyte |
| Cytochrome P450 | 0.3735 | INHERITED FROM: embryonic/larval hindgut || larval VNC neuropil glial cell || embryonic ventral epidermis || embryonic/larval foregut || tract neuropil || larval neuropil glial cell || CNS glial cell || neuropil associated CNS glial cell || commissure || embryonic/larval glial cell || midline crossing tract || midgut || epidermis || neuropil glial sheath || tract || hindgut || midline glial cell |
| GroEL apical domain-like | 0.4091 | INHERITED FROM: circulatory system || adult heart || adult circulatory system || adult dorsal vessel |
| Tubulin nucleotide-binding domain-like | 0.4397 | INHERITED FROM: spermatid cyst || fat cell || spermatid |
| GroEL equatorial domain-like | 0.4495 | INHERITED FROM: circulatory system || adult heart || adult circulatory system || adult dorsal vessel |
| GroEL-intermediate domain like | 0.4495 | INHERITED FROM: circulatory system || adult heart || adult circulatory system || adult dorsal vessel |
| Spectrin repeat | 0.4495 | INHERITED FROM: ipsilateral tract || longitudinal connective || fat cell || midgut epithelium || gut epithelial section || gut epithelium || middle midgut || copper cell || neuron projection bundle of ventral nerve cord || enterocyte || oocyte || connective || tract || embryonic/larval gut |
| Invertebrate chitin-binding proteins | 0.4905 | INHERITED FROM: embryonic/larval trachea || primary trachea || embryonic/larval integumentary system || embryonic/larval tracheal system || embryonic/larval dorsal trunk || tracheal system || embryonic/larval cuticle |
| vWA-like | 0.4946 | INHERITED FROM: primary trachea || pupal cuticle || prepupal integumentary system || embryonic/larval epidermis || cuticle layer || procuticle || endocuticular specialization |
| Actin depolymerizing proteins | 0.5433 | INHERITED FROM: follicle cell |
| CoA-dependent acyltransferases | 0.5466 | INHERITED FROM: adult somatic muscle || skeletal muscle of thorax || flight muscle || adult muscle system || skeletal muscle of mesothorax |
| RING/U-box | 0.5703 | INHERITED FROM: embryonic/larval garland organ || embryonic/larval garland cell || garland cell |
| (Phosphotyrosine protein) phosphatases II | 0.5783 | INHERITED FROM: intersegmental nerve || medial lobe of adult mushroom body |
| SET domain | 0.7612 | INHERITED FROM: metathoracic leg || haltere |
| Cadherin-like | 0.8024 | INHERITED FROM: photoreceptor cell R4 |
| P-loop containing nucleoside triphosphate hydrolases | 0.8233 | INHERITED FROM: reproductive system || gonad |
| Leucine zipper domain | 0.8261 | INHERITED FROM: adult heart || embryonic dorsal epidermis || adult dorsal vessel |
| SCOP hierarchy in SUPERFAMILY | 0.8426 | INHERITED FROM: adult heart || adult circulatory system || adult dorsal vessel |
| TPR-like | 0.9085 | INHERITED FROM: antennal nerve || adult antennal nerve |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| L30e-like | 0 | Direct |
| Bromodomain | 0 | Direct |
| B-box zinc-binding domain | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| Orange domain-like | 0 | Direct |
| ARID-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
| SNARE-like | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| BAR/IMD domain-like | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| TIMP-like | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| C-type lectin-like | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Kelch motif | 0 | Direct |
| NHL repeat | 0 | Direct |
| MIR domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| PX domain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| L27 domain | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Serpins | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| TRAF domain-like | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Sema domain | 0 | Direct |
| Periplasmic binding protein-like I | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| TATA-box binding protein-like | 0 | Direct |
| Toll/Interleukin receptor TIR domain | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| ACP-like | 0 | Direct |
| Clavaminate synthase-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| Nucleotide-diphospho-sugar transferases | 0 | Direct |
| HMG-box | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| DBL homology domain (DH-domain) | 0 | Direct |
| SAP domain | 0 | Direct |
| SIS domain | 0 | Direct |
| (Trans)glycosidases | 0 | Direct |
| EGF/Laminin | 0 | Direct |
| Ypt/Rab-GAP domain of gyp1p | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| Snake toxin-like | 0 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| YWTD domain | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| R3H domain | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| FKBP-like | 0 | Direct |
| NAD kinase/diacylglycerol kinase-like | 0 | Direct |
| Multidrug resistance efflux transporter EmrE | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| DNase I-like | 0 | Direct |
| Adenine nucleotide alpha hydrolases-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| PDZ domain-like | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Caspase-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Concanavalin A-like lectins/glucanases | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0 | Direct |
| Glycerol-3-phosphate (1)-acyltransferase | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Cytokine | 0 | Direct |
| DEATH domain | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| Homeodomain-like | 0.00001778 | Direct |
| beta-beta-alpha zinc fingers | 0.0003121 | Direct |
| PH domain-like | 0.004664 | Inherited |
| Fibronectin type III | 0.02856 | Inherited |
| L domain-like | 0.03875 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.05873 | Inherited |
| SH2 domain | 0.1224 | Inherited |
| POZ domain | 0.1305 | Inherited |
| Protein kinase-like (PK-like) | 0.151 | Inherited |
| Immunoglobulin | 0.1863 | Inherited |
| Growth factor receptor domain | 0.2142 | Inherited |
| p53-like transcription factors | 0.2354 | Inherited |
| Cysteine-rich domain | 0.2587 | Inherited |
| Cystine-knot cytokines | 0.2587 | Inherited |
| Calponin-homology domain, CH-domain | 0.2587 | Inherited |
| Ankyrin repeat | 0.2803 | Inherited |
| HAD-like | 0.2841 | Inherited |
| E set domains | 0.2906 | Inherited |
| Cytochrome P450 | 0.3735 | Inherited |
| GroEL apical domain-like | 0.4091 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.4397 | Inherited |
| GroEL equatorial domain-like | 0.4495 | Inherited |
| GroEL-intermediate domain like | 0.4495 | Inherited |
| Spectrin repeat | 0.4495 | Inherited |
| Invertebrate chitin-binding proteins | 0.4905 | Inherited |
| vWA-like | 0.4946 | Inherited |
| Actin depolymerizing proteins | 0.5433 | Inherited |
| CoA-dependent acyltransferases | 0.5466 | Inherited |
| RING/U-box | 0.5703 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 0.5783 | Inherited |
| SET domain | 0.7612 | Inherited |
| Cadherin-like | 0.8024 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.8233 | Inherited |
| Leucine zipper domain | 0.8261 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.8426 | Inherited |
| TPR-like | 0.9085 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (Not in SDFA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | DIRECT |
| EGF-type module | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| Ngr ectodomain-like | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| C-type lectin domain | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| MBT repeat | 0 | DIRECT |
| SAM (sterile alpha motif) domain | 0 | DIRECT |
| Phosphotyrosine-binding domain (PTB) | 0 | DIRECT |
| Pyk2-associated protein beta ARF-GAP domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Choline/Carnitine O-acyltransferase | 0 | DIRECT |
| BCR-homology GTPase activation domain (BH-domain) | 0 | DIRECT |
| Dachshund-homology domain | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| PDZ domain | 0 | DIRECT |
| PX domain | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Serpins | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Synaptotagmin-like (S variant) | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| SPRY domain | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
| HMG-box | 0 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| Forkhead DNA-binding domain | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| DBL homology domain (DH-domain) | 0 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0 | DIRECT |
| LIM domain | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Diap1 N-terninal region-like | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| B-box zinc-binding domain | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Transforming growth factor (TGF)-beta | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Tetramerization domain of potassium channels | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| L-arabinose binding protein-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Bromodomain | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| FKBP immunophilin/proline isomerase | 0 | DIRECT |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | DIRECT |
| Nucleotide and nucleoside kinases | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| TATA-box binding protein (TBP), C-terminal domain | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| Motor proteins | 0 | DIRECT |
| Homeodomain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| Classic zinc finger, C2H2 | 0.009845 | INHERITED FROM: integumentary system || adult integumentary system || region of integument |
| Fibronectin type III | 0.02679 | INHERITED FROM: tract neuropil || adult pacemaker neuron || neuron projection bundle || pacemaker neuron || LNv neuron || commissure || nerve || synaptic neuropil || neuron projection bundle of ventral nerve cord || gustatory receptor neuron || s-LNv neuron || LN period neuron || lobe system of adult mushroom body |
| Protein kinases, catalytic subunit | 0.1007 | INHERITED FROM: embryonic/larval integumentary system || synaptic neuropil || somatic cell of ovariole || intestinal stem cell || ovariole || photoreceptor cell R8 of pale ommatidium |
| SH2 domain | 0.1142 | INHERITED FROM: cyst progenitor cell || photoreceptor cell R7 || egg chamber || adult peripheral nervous system || photoreceptor cell || midline crossing tract || rhabdomeric photoreceptor cell || histaminergic neuron || ommatidium || adult optic lobe neuron |
| BTB/POZ domain | 0.1515 | INHERITED FROM: prothoracic tarsal segment || terminal filament |
| I set domains | 0.1665 | INHERITED FROM: tract neuropil || leg taste bristle chemosensory neuron || adult pacemaker neuron || neuron projection bundle || adult central nervous system || pacemaker neuron || adult descending neuron || gustatory system neuron || LNv neuron || synaptic neuropil block || commissure || embryonic/larval lateral glial cell || synaptic neuropil subdomain || antennal lobe glomerulus || synaptic neuropil || adult brain || embryonic somatic muscle || gustatory receptor neuron || s-LNv neuron || larval abdominal sensory neuron || visceral muscle fiber || neuropil glial sheath || connective || mechanosensory system neuron || adult cerebral ganglion || lobe system of adult mushroom body || interface glial cell |
| Nuclear receptor | 0.1665 | INHERITED FROM: larval abdominal neuromere || abdominal neuromere || supraesophageal ganglion neuron || synaptic neuropil block || interneuron || synaptic neuropil || mushroom body gamma-lobe || mushroom body intrinsic neuron |
| Calponin-homology domain, CH-domain | 0.2423 | INHERITED FROM: indirect flight muscle || flight muscle || abdominal segmental nerve |
| Ankyrin repeat | 0.2794 | INHERITED FROM: Johnston organ neuron || ventral multidendritic neuron |
| LDL receptor-like module | 0.3532 | INHERITED FROM: embryonic/larval dorsal trunk |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.3532 | INHERITED FROM: embryonic/larval garland organ || embryonic/larval garland cell || garland cell |
| Cytochrome P450 | 0.3532 | INHERITED FROM: embryonic/larval hindgut || larval VNC neuropil glial cell || embryonic ventral epidermis || embryonic/larval foregut || tract neuropil || larval neuropil glial cell || CNS glial cell || neuropil associated CNS glial cell || commissure || embryonic/larval glial cell || midline crossing tract || midgut || epidermis || neuropil glial sheath || tract || hindgut || midline glial cell |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3892 | INHERITED FROM: intersegmental nerve |
| Growth factor receptor domain | 0.3892 | INHERITED FROM: embryonic hemocoel || embryonic/larval tracheal system || proventriculus || ocellus || salivary gland || somatic cell of testis || tibia || tracheal system || germinal proliferation center || head mesoderm derived embryonic hemocyte || embryonic hemocyte || embryonic/larval lymph gland || ocellar triangle || integumentary specialisation || primary lobe of embryonic/larval lymph gland || hindgut |
| Tubulin, GTPase domain | 0.4178 | INHERITED FROM: spermatid cyst || fat cell || spermatid |
| Spectrin repeat | 0.4293 | INHERITED FROM: ipsilateral tract || longitudinal connective || embryonic/larval alimentary canal || fat cell || midgut epithelium || gut epithelial section || gut epithelium || middle midgut || copper cell || neuron projection bundle of ventral nerve cord || enterocyte || oocyte || connective || tract || embryonic/larval gut |
| Group II chaperonin (CCT, TRIC), apical domain | 0.4719 | INHERITED FROM: circulatory system || adult heart || adult circulatory system || adult dorsal vessel |
| Histone lysine methyltransferases | 0.4719 | INHERITED FROM: metathoracic leg || haltere |
| T-box | 0.5211 | INHERITED FROM: embryonic/larval dorsal vessel |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.5211 | INHERITED FROM: circulatory system || adult heart || adult circulatory system || adult dorsal vessel |
| Ubiquitin-related | 0.6458 | INHERITED FROM: mushroom body extrinsic neuron |
| G proteins | 0.684 | INHERITED FROM: wing hair || circulatory system || embryonic/larval adipose system || embryonic/larval fat body || hemocyte |
| Cyclin | 0.6911 | INHERITED FROM: germarium |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0.7005 | INHERITED FROM: adult heart || adult circulatory system || adult dorsal vessel |
| Proteasome subunits | 0.7534 | INHERITED FROM: embryonic/larval fat body |
| Leucine zipper domain | 0.8236 | INHERITED FROM: adult heart || embryonic dorsal epidermis |
| Cadherin | 0.8371 | INHERITED FROM: wing hair || photoreceptor cell R4 || outer photoreceptor cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | Direct |
| EGF-type module | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| Ngr ectodomain-like | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| ets domain | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| FHA domain | 0 | Direct |
| Paired domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| NHL repeat | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| C-type lectin domain | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Kelch motif | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
| MBT repeat | 0 | Direct |
| SAM (sterile alpha motif) domain | 0 | Direct |
| Phosphotyrosine-binding domain (PTB) | 0 | Direct |
| Pyk2-associated protein beta ARF-GAP domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| R3H domain | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Choline/Carnitine O-acyltransferase | 0 | Direct |
| BCR-homology GTPase activation domain (BH-domain) | 0 | Direct |
| Dachshund-homology domain | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| PDZ domain | 0 | Direct |
| PX domain | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| BAR domain | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Serpins | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Synaptotagmin-like (S variant) | 0 | Direct |
| YWTD domain | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| SPRY domain | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
| HMG-box | 0 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| VHS domain | 0 | Direct |
| Forkhead DNA-binding domain | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| ARID domain | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| DBL homology domain (DH-domain) | 0 | Direct |
| Toll/Interleukin receptor TIR domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Pleckstrin-homology domain (PH domain) | 0 | Direct |
| LIM domain | 0 | Direct |
| ZZ domain | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Diap1 N-terninal region-like | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| Plexin repeat | 0 | Direct |
| B-box zinc-binding domain | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Transforming growth factor (TGF)-beta | 0 | Direct |
| Sema domain | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| L27 domain | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Laminin-type module | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Tetramerization domain of potassium channels | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| SAP domain | 0 | Direct |
| L-arabinose binding protein-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| Bromodomain | 0 | Direct |
| Pepsin-like | 0 | Direct |
| FKBP immunophilin/proline isomerase | 0 | Direct |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Cullin repeat | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | Direct |
| Nucleotide and nucleoside kinases | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| TATA-box binding protein (TBP), C-terminal domain | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| Motor proteins | 0 | Direct |
| Homeodomain | 0 | Direct |
| MIR domain | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| Classic zinc finger, C2H2 | 0.009845 | Inherited |
| Fibronectin type III | 0.02679 | Inherited |
| Protein kinases, catalytic subunit | 0.1007 | Inherited |
| SH2 domain | 0.1142 | Inherited |
| BTB/POZ domain | 0.1515 | Inherited |
| I set domains | 0.1665 | Inherited |
| Nuclear receptor | 0.1665 | Inherited |
| Calponin-homology domain, CH-domain | 0.2423 | Inherited |
| Ankyrin repeat | 0.2794 | Inherited |
| LDL receptor-like module | 0.3532 | Inherited |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.3532 | Inherited |
| Cytochrome P450 | 0.3532 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3892 | Inherited |
| Growth factor receptor domain | 0.3892 | Inherited |
| Tubulin, GTPase domain | 0.4178 | Inherited |
| Spectrin repeat | 0.4293 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.4719 | Inherited |
| Histone lysine methyltransferases | 0.4719 | Inherited |
| T-box | 0.5211 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.5211 | Inherited |
| Ubiquitin-related | 0.6458 | Inherited |
| G proteins | 0.684 | Inherited |
| Cyclin | 0.6911 | Inherited |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0.7005 | Inherited |
| Proteasome subunits | 0.7534 | Inherited |
| Leucine zipper domain | 0.8236 | Inherited |
| Cadherin | 0.8371 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Multidrug resistance efflux transporter EmrE | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| DBL homology domain (DH-domain) | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| PDZ domain-like | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| PX domain | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| HMG-box | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Concanavalin A-like lectins/glucanases | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Glycerol-3-phosphate (1)-acyltransferase | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| BAR/IMD domain-like | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| CBS-domain pair | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| Serpins | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Periplasmic binding protein-like I | 0 | DIRECT |
| TIMP-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| TATA-box binding protein-like | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Nucleotide-diphospho-sugar transferases | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Clavaminate synthase-like | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Snake toxin-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
| EGF/Laminin | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| TRAF domain-like | 0 | DIRECT |
| Bromodomain | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| B-box zinc-binding domain | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0 | DIRECT |
| (Trans)glycosidases | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Ypt/Rab-GAP domain of gyp1p | 0 | DIRECT |
| FKBP-like | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
| C-type lectin-like | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
| Homeodomain-like | 0.00001294 | DIRECT |
| beta-beta-alpha zinc fingers | 0.0002281 | DIRECT |
| PH domain-like | 0.003378 | INHERITED FROM: embryonic foregut |
| Fibronectin type III | 0.02222 | INHERITED FROM: commissure || pacemaker neuron || dendritic arborizing neuron || adult cerebrum || neuron projection bundle of ventral nerve cord || tract neuropil || synaptic neuropil || s-LNv neuron || LNv neuron || adult pacemaker neuron || lobe system of adult mushroom body || LN period neuron || leg taste bristle chemosensory neuron || neuron projection bundle |
| L domain-like | 0.03053 | INHERITED FROM: BAlc1 lineage neuron |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.04737 | INHERITED FROM: adult external thorax || integumentary system || adult integumentary system || region of integument |
| SH2 domain | 0.1033 | INHERITED FROM: egg chamber || tract || histaminergic neuron || midline crossing tract || photoreceptor cell || adult peripheral nervous system || rhabdomeric photoreceptor cell || ommatidium || photoreceptor cell R7 || adult optic lobe neuron || embryonic/larval integumentary system || connective || cyst progenitor cell |
| POZ domain | 0.1105 | INHERITED FROM: terminal filament |
| Protein kinase-like (PK-like) | 0.1289 | INHERITED FROM: gut epithelial section || photoreceptor cell R8 of pale ommatidium || intestinal stem cell || somatic cell of ovariole || synaptic neuropil || pupal/adult digestive system || embryonic/larval integumentary system || nervous system || ovariole |
| Immunoglobulin | 0.162 | INHERITED FROM: commissure || pacemaker neuron || nerve || neuropil glial sheath || central nervous system || glial cell || neuron projection bundle of ventral nerve cord || tract neuropil || synaptic neuropil || abdominal segmental nerve || abdominal nerve || adult brain || LNv neuron || adult pacemaker neuron || longitudinal muscle || connective || lobe system of adult mushroom body || nervous system || antennal lobe glomerulus || LN period neuron || leg taste bristle chemosensory neuron || neuron projection bundle |
| Growth factor receptor domain | 0.1875 | INHERITED FROM: head mesoderm derived embryonic hemocyte || integumentary specialisation || germinal proliferation center || cortical zone of lymph gland primary lobe || vMP2 neuron || embryonic/larval tracheal system || dMP2 neuron || wing vein L4 || embryonic/larval lymph gland || wing vein L2 || tracheal system || RP2sib neuron || hindgut || adult circulatory system || embryonic hemocoel || primary lobe of embryonic/larval lymph gland || adult heart || somatic cell of testis || endocuticle || proventriculus || GABAergic neuron || photoreceptor cell R7 || ocellus || adult dorsal vessel || ventral nervous system || ocellar triangle || procuticle || germinal proliferation center hub || surface associated glial cell || dorsal acute muscle || ventral midline || retinal pigment cell || embryonic/larval midline of ventral nerve cord || embryonic fiber tract || fascicle || embryonic hemocyte |
| p53-like transcription factors | 0.2073 | INHERITED FROM: mesothoracic tergum || head mesoderm derived embryonic hemocyte || adult external thorax || tract || embryonic hemocoel || circulatory system || tagmatic subdivision of integument || integumentary system || embryonic/larval circulatory system || integumentary process || embryonic hemocyte |
| Calponin-homology domain, CH-domain | 0.2294 | INHERITED FROM: flight muscle || abdominal segmental nerve || indirect flight muscle |
| Cysteine-rich domain | 0.2294 | INHERITED FROM: embryonic/larval integumentary system |
| Cystine-knot cytokines | 0.2294 | INHERITED FROM: stigmatophore || spiracle || embryonic/larval posterior spiracle || embryonic/larval spiracle |
| Ankyrin repeat | 0.2503 | INHERITED FROM: Johnston organ neuron |
| HAD-like | 0.2538 | INHERITED FROM: rhabdomere of eye photoreceptor cell |
| E set domains | 0.2599 | INHERITED FROM: head mesoderm derived embryonic hemocyte || embryonic hemocoel || embryonic hemocyte |
| Cytochrome P450 | 0.3411 | INHERITED FROM: commissure || neuropil glial sheath || tract || larval neuropil glial cell || hindgut || embryonic/larval glial cell || tract neuropil || midline crossing tract || epidermis || embryonic/larval foregut || larval VNC neuropil glial cell || CNS glial cell || midline glial cell || embryonic ventral epidermis || embryonic/larval hindgut || midgut || neuropil associated CNS glial cell || embryonic/first instar larval cuticle |
| LDL receptor-like module | 0.3411 | INHERITED FROM: embryonic/larval dorsal trunk |
| GroEL apical domain-like | 0.3764 | INHERITED FROM: adult circulatory system || circulatory system || adult heart || adult dorsal vessel |
| Tubulin nucleotide-binding domain-like | 0.4073 | INHERITED FROM: fat cell || spermatid || spermatid cyst |
| Spectrin repeat | 0.4171 | INHERITED FROM: fat cell || middle midgut || tract || midgut epithelium || gut epithelial section || neuron projection bundle of ventral nerve cord || embryonic/larval alimentary canal || gut epithelium || enterocyte || ipsilateral tract || oocyte || longitudinal connective || connective || copper cell || embryonic/larval gut |
| GroEL-intermediate domain like | 0.4171 | INHERITED FROM: adult circulatory system || circulatory system || adult heart || adult dorsal vessel |
| GroEL equatorial domain-like | 0.4171 | INHERITED FROM: adult circulatory system || circulatory system || adult heart || adult dorsal vessel |
| Invertebrate chitin-binding proteins | 0.4584 | INHERITED FROM: primary trachea || embryonic/larval tracheal system || tracheal system || embryonic/larval trachea || embryonic/larval cuticle || embryonic/larval integumentary system || embryonic/larval dorsal trunk |
| vWA-like | 0.4623 | INHERITED FROM: primary trachea || embryonic/larval epidermis || endocuticular specialization || prepupal integumentary system || pupal cuticle || procuticle || cuticle layer |
| Actin depolymerizing proteins | 0.5122 | INHERITED FROM: follicle cell |
| CoA-dependent acyltransferases | 0.5158 | INHERITED FROM: flight muscle || adult somatic muscle || skeletal muscle of thorax || adult muscle system || skeletal muscle of mesothorax |
| RING/U-box | 0.54 | INHERITED FROM: garland cell || embryonic/larval garland cell || embryonic/larval garland organ |
| (Phosphotyrosine protein) phosphatases II | 0.5485 | INHERITED FROM: medial lobe of adult mushroom body || intersegmental nerve |
| SET domain | 0.7394 | INHERITED FROM: metathoracic leg || haltere |
| Cadherin-like | 0.7831 | INHERITED FROM: photoreceptor cell R4 |
| Ribonuclease H-like | 0.8029 | INHERITED FROM: melanotic mass |
| P-loop containing nucleoside triphosphate hydrolases | 0.8056 | INHERITED FROM: reproductive system || gonad |
| Leucine zipper domain | 0.8084 | INHERITED FROM: adult heart || adult dorsal vessel || embryonic dorsal epidermis |
| TPR-like | 0.8976 | INHERITED FROM: antennal nerve || adult antennal nerve |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Multidrug resistance efflux transporter EmrE | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| DBL homology domain (DH-domain) | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| PDZ domain-like | 0 | Direct |
| DNase I-like | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| Cytokine | 0 | Direct |
| PX domain | 0 | Direct |
| SNARE-like | 0 | Direct |
| HMG-box | 0 | Direct |
| ARID-like | 0 | Direct |
| Concanavalin A-like lectins/glucanases | 0 | Direct |
| MIR domain | 0 | Direct |
| NAD kinase/diacylglycerol kinase-like | 0 | Direct |
| SIS domain | 0 | Direct |
| Glycerol-3-phosphate (1)-acyltransferase | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| SAP domain | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| NHL repeat | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| BAR/IMD domain-like | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| L30e-like | 0 | Direct |
| CBS-domain pair | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| Serpins | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Periplasmic binding protein-like I | 0 | Direct |
| TIMP-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| TATA-box binding protein-like | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Nucleotide-diphospho-sugar transferases | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Clavaminate synthase-like | 0 | Direct |
| ACP-like | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Snake toxin-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Adenine nucleotide alpha hydrolases-like | 0 | Direct |
| EGF/Laminin | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| L27 domain | 0 | Direct |
| Caspase-like | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Sema domain | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| TRAF domain-like | 0 | Direct |
| Bromodomain | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| B-box zinc-binding domain | 0 | Direct |
| Kelch motif | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| Toll/Interleukin receptor TIR domain | 0 | Direct |
| (Trans)glycosidases | 0 | Direct |
| R3H domain | 0 | Direct |
| Ypt/Rab-GAP domain of gyp1p | 0 | Direct |
| FKBP-like | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| YWTD domain | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
| C-type lectin-like | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
| Homeodomain-like | 0.00001294 | Direct |
| beta-beta-alpha zinc fingers | 0.0002281 | Direct |
| PH domain-like | 0.003378 | Inherited |
| Fibronectin type III | 0.02222 | Inherited |
| L domain-like | 0.03053 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.04737 | Inherited |
| SH2 domain | 0.1033 | Inherited |
| POZ domain | 0.1105 | Inherited |
| Protein kinase-like (PK-like) | 0.1289 | Inherited |
| Immunoglobulin | 0.162 | Inherited |
| Growth factor receptor domain | 0.1875 | Inherited |
| p53-like transcription factors | 0.2073 | Inherited |
| Calponin-homology domain, CH-domain | 0.2294 | Inherited |
| Cysteine-rich domain | 0.2294 | Inherited |
| Cystine-knot cytokines | 0.2294 | Inherited |
| Ankyrin repeat | 0.2503 | Inherited |
| HAD-like | 0.2538 | Inherited |
| E set domains | 0.2599 | Inherited |
| Cytochrome P450 | 0.3411 | Inherited |
| LDL receptor-like module | 0.3411 | Inherited |
| GroEL apical domain-like | 0.3764 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.4073 | Inherited |
| Spectrin repeat | 0.4171 | Inherited |
| GroEL-intermediate domain like | 0.4171 | Inherited |
| GroEL equatorial domain-like | 0.4171 | Inherited |
| Invertebrate chitin-binding proteins | 0.4584 | Inherited |
| vWA-like | 0.4623 | Inherited |
| Actin depolymerizing proteins | 0.5122 | Inherited |
| CoA-dependent acyltransferases | 0.5158 | Inherited |
| RING/U-box | 0.54 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 0.5485 | Inherited |
| SET domain | 0.7394 | Inherited |
| Cadherin-like | 0.7831 | Inherited |
| Ribonuclease H-like | 0.8029 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.8056 | Inherited |
| Leucine zipper domain | 0.8084 | Inherited |
| TPR-like | 0.8976 | Inherited |
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57716,46689
57716 - Glucocorticoid receptor-like (DNA-binding domain)
46689 - Homeodomain-like | 0 | DIRECT |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | DIRECT |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
49854,49854
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
55945,55945
55945 - TATA-box binding protein-like
55945 - TATA-box binding protein-like | 0 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.0006371 | DIRECT |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1396 | INHERITED FROM: commissure || pacemaker neuron || neuropil glial sheath || chemosensory neuron || neuron projection bundle of ventral nerve cord || giant fiber neuron || adult antennal lobe glomerulus || tract neuropil || adult antennal lobe || s-LNv neuron || mechanosensory neuron || gustatory receptor neuron || LNv neuron || adult pacemaker neuron || connective || lobe system of adult mushroom body || chemosensory system neuron || neuropil associated CNS glial cell || adult descending neuron || antennal lobe glomerulus || LN period neuron || leg taste bristle chemosensory neuron || neuron projection bundle |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3123 | INHERITED FROM: commissure || pacemaker neuron || neuropil glial sheath || adult cerebral ganglion || central nervous system || ganglion || embryonic somatic muscle || tract neuropil || synaptic neuropil || s-LNv neuron || adult brain || LNv neuron || adult pacemaker neuron || longitudinal muscle || connective || lobe system of adult mushroom body || nervous system || antennal lobe glomerulus || LN period neuron || synaptic neuropil block || leg taste bristle chemosensory neuron || neuron projection bundle |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.4171 | INHERITED FROM: adult circulatory system || circulatory system || adult heart || adult dorsal vessel |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.4171 | INHERITED FROM: adult circulatory system || circulatory system || adult heart || adult dorsal vessel |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.4171 | INHERITED FROM: mechanosensory system neuron || mechanosensory neuron |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4692 | INHERITED FROM: bristle of mesothoracic tergum |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.8259 | INHERITED FROM: wing hair || photoreceptor cell R4 || outer photoreceptor cell |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.8679 | INHERITED FROM: bouton |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57716,46689
57716 - Glucocorticoid receptor-like (DNA-binding domain)
46689 - Homeodomain-like | 0 | Direct |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | Direct |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
49854,49854
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
55945,55945
55945 - TATA-box binding protein-like
55945 - TATA-box binding protein-like | 0 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | Direct |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.0006371 | Direct |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1396 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3123 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.4171 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.4171 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.4171 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4692 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.8259 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.8679 | Inherited |
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1875 | INHERITED FROM: pacemaker neuron || neuropil glial sheath || embryonic/larval central nervous system || chemosensory neuron || eo neuron || neuron projection bundle of ventral nerve cord || giant fiber neuron || adult antennal lobe glomerulus || adult antennal lobe || s-LNv neuron || mechanosensory system neuron || mechanosensory neuron || gustatory receptor neuron || LNv neuron || adult pacemaker neuron || connective || lobe system of adult mushroom body || chemosensory system neuron || neuropil associated CNS glial cell || adult descending neuron || antennal lobe glomerulus || LN period neuron || leg taste bristle chemosensory neuron || neuron projection bundle |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.4171 | INHERITED FROM: adult circulatory system || circulatory system || adult heart || adult dorsal vessel |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.4808 | INHERITED FROM: commissure || pacemaker neuron || central nervous system || neuron projection bundle of ventral nerve cord || tract neuropil || synaptic neuropil || s-LNv neuron || interneuron || adult brain || gustatory receptor neuron || LNv neuron || adult pacemaker neuron || connective || lobe system of adult mushroom body || embryonic/larval garland cell || synaptic neuropil block || leg taste bristle chemosensory neuron || embryonic/larval garland organ || neuron projection bundle |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.8259 | INHERITED FROM: wing hair || photoreceptor cell R4 || outer photoreceptor cell |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1875 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.4171 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.4808 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.8259 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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