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Fly Anatomy (FA): cell
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (Not in SDFA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Isoprenyl diphosphate synthases | 0 | DIRECT |
| MSP-like | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| CAD domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Kelch motif | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| MBT repeat | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| SPRY domain | 0 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
| beta-CASP RNA-metabolising hydrolases | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| B-box zinc-binding domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Transforming growth factor (TGF)-beta | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Tetramerization domain of potassium channels | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Ankyrin repeat | 0.01246 | INHERITED FROM: ventral multidendritic neuron || Johnston organ neuron |
| Double-stranded RNA-binding domain (dsRBD) | 0.07455 | INHERITED FROM: germline cell |
| Spectrin repeat | 0.09687 | INHERITED FROM: fat cell || copper cell || oocyte || enterocyte |
| Protein kinases, catalytic subunit | 0.1382 | INHERITED FROM: photoreceptor cell R8 of pale ommatidium || somatic cell of ovariole || intestinal stem cell |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.1628 | INHERITED FROM: intestinal stem cell |
| Ubiquitin-related | 0.2057 | INHERITED FROM: mushroom body extrinsic neuron |
| Transducin (alpha subunit), insertion domain | 0.2105 | INHERITED FROM: eo neuron |
| Calponin-homology domain, CH-domain | 0.2242 | INHERITED FROM: indirect flight muscle || flight muscle |
| I set domains | 0.2324 | INHERITED FROM: gustatory system neuron || mechanosensory system neuron || pacemaker neuron || adult descending neuron || visceral muscle fiber || interface glial cell || embryonic/larval lateral glial cell || cardioblast || LNv neuron || leg taste bristle chemosensory neuron || embryonic somatic muscle || embryonic cardioblast || larval abdominal sensory neuron || s-LNv neuron || gustatory receptor neuron || embryonic heart cardioblast || adult pacemaker neuron |
| RecA protein-like (ATPase-domain) | 0.2733 | INHERITED FROM: female germline cell || nurse cell || presumptive oocyte || oocyte |
| SMAD domain | 0.2733 | INHERITED FROM: female germline stem cell || germline stem cell |
| ZZ domain | 0.2733 | INHERITED FROM: indirect flight muscle || skeletal muscle of mesothorax || flight muscle || skeletal muscle of thorax || adult somatic muscle |
| Homeodomain | 0.2855 | INHERITED FROM: A1-7 ventral acute muscle 1 || EL neuron || maxillary palp olfactory receptor neuron || dorsal margin photoreceptor || hypodermal muscle of prothorax || interneuron || ventral intersegmental muscle || thoracic neuroblast || U neuron || embryonic neuroblast || prothoracic ventral intersegmental muscle || embryonic/larval neuron || uniglomerular antennal lobe projection neuron |
| PDZ domain | 0.3054 | INHERITED FROM: somatic cell of ovariole |
| Cap-Gly domain | 0.3532 | INHERITED FROM: interneuron |
| Choline/Carnitine O-acyltransferase | 0.3532 | INHERITED FROM: skeletal muscle of mesothorax || flight muscle || somatic muscle || syncytium || skeletal muscle of thorax || adult somatic muscle |
| Motor proteins | 0.3532 | INHERITED FROM: germline cell |
| Cadherin | 0.37 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell |
| PLC-like (P variant) | 0.37 | INHERITED FROM: larval dorsal multidendritic neuron ddaC || larval dorsal multidendritic neuron || head mesoderm derived embryonic hemocyte |
| Fibronectin type III | 0.374 | INHERITED FROM: pacemaker neuron || LN period neuron || LNv neuron || s-LNv neuron || gustatory receptor neuron || embryonic heart cardioblast || adult pacemaker neuron |
| EGF-type module | 0.4537 | INHERITED FROM: pigment cell || embryonic/larval midgut cell || adult midgut progenitor cell || hub cell || embryonic pericardial cell || head mesoderm derived embryonic hemocyte || dorsal acute muscle |
| Paired domain | 0.5035 | INHERITED FROM: EL neuron || EG neuron || RP2 motor neuron || U neuron |
| Cyclin | 0.5035 | INHERITED FROM: female germline cell |
| Caspase catalytic domain | 0.5395 | INHERITED FROM: peptidergic neuron |
| HLH, helix-loop-helix DNA-binding domain | 0.542 | INHERITED FROM: EL neuron || sensory mother cell || 5-6I of thorax |
| Nuclear receptor ligand-binding domain | 0.571 | INHERITED FROM: supraesophageal ganglion neuron || mushroom body intrinsic neuron || interneuron |
| Nuclear receptor | 0.5931 | INHERITED FROM: supraesophageal ganglion neuron || mushroom body intrinsic neuron || interneuron |
| G proteins | 0.681 | INHERITED FROM: hemocyte |
| Cytochrome P450 | 0.6813 | INHERITED FROM: neuropil associated CNS glial cell || CNS glial cell || midline glial cell || embryonic/larval glial cell || larval VNC neuropil glial cell || larval neuropil glial cell |
| Growth factor receptor domain | 0.7527 | INHERITED FROM: embryonic hemocyte || head mesoderm derived embryonic hemocyte || somatic cell of testis |
| Forkhead DNA-binding domain | 0.818 | INHERITED FROM: RP2sib neuron |
| Hairy Orange domain | 0.8232 | INHERITED FROM: EL neuron || EG neuron |
| SH2 domain | 0.8606 | INHERITED FROM: photoreceptor cell || rhabdomeric photoreceptor cell || histaminergic neuron || photoreceptor cell R7 || cyst progenitor cell || sensory organ cell || adult optic lobe neuron |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.8756 | INHERITED FROM: garland cell || embryonic/larval garland cell |
| Classic zinc finger, C2H2 | 1 | INHERITED FROM: embryonic ganglion mother cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Isoprenyl diphosphate synthases | 0 | Direct |
| MSP-like | 0 | Direct |
| NHL repeat | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| CAD domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Kelch motif | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| MBT repeat | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| BAR domain | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| YWTD domain | 0 | Direct |
| SPRY domain | 0 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
| beta-CASP RNA-metabolising hydrolases | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Pointed domain | 0 | Direct |
| B-box zinc-binding domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Transforming growth factor (TGF)-beta | 0 | Direct |
| Sema domain | 0 | Direct |
| Laminin-type module | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Tetramerization domain of potassium channels | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| SAP domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Cullin repeat | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Prefoldin | 0 | Direct |
| MIR domain | 0 | Direct |
| Ankyrin repeat | 0.01246 | Inherited |
| Double-stranded RNA-binding domain (dsRBD) | 0.07455 | Inherited |
| Spectrin repeat | 0.09687 | Inherited |
| Protein kinases, catalytic subunit | 0.1382 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.1628 | Inherited |
| Ubiquitin-related | 0.2057 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.2105 | Inherited |
| Calponin-homology domain, CH-domain | 0.2242 | Inherited |
| I set domains | 0.2324 | Inherited |
| RecA protein-like (ATPase-domain) | 0.2733 | Inherited |
| SMAD domain | 0.2733 | Inherited |
| ZZ domain | 0.2733 | Inherited |
| Homeodomain | 0.2855 | Inherited |
| PDZ domain | 0.3054 | Inherited |
| Cap-Gly domain | 0.3532 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.3532 | Inherited |
| Motor proteins | 0.3532 | Inherited |
| Cadherin | 0.37 | Inherited |
| PLC-like (P variant) | 0.37 | Inherited |
| Fibronectin type III | 0.374 | Inherited |
| EGF-type module | 0.4537 | Inherited |
| Paired domain | 0.5035 | Inherited |
| Cyclin | 0.5035 | Inherited |
| Caspase catalytic domain | 0.5395 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.542 | Inherited |
| Nuclear receptor ligand-binding domain | 0.571 | Inherited |
| Nuclear receptor | 0.5931 | Inherited |
| G proteins | 0.681 | Inherited |
| Cytochrome P450 | 0.6813 | Inherited |
| Growth factor receptor domain | 0.7527 | Inherited |
| Forkhead DNA-binding domain | 0.818 | Inherited |
| Hairy Orange domain | 0.8232 | Inherited |
| SH2 domain | 0.8606 | Inherited |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.8756 | Inherited |
| Classic zinc finger, C2H2 | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | DIRECT |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | DIRECT |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.117 | INHERITED FROM: rhabdomeric photoreceptor cell || embryonic/larval pericardial cell || embryonic/larval somatic muscle || sensory organ cell || eye photoreceptor cell stalk || pericardial cell || secondary pigment cell || nephrocyte || hub cell || tertiary pigment cell |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1361 | INHERITED FROM: pacemaker neuron || interommatidial precursor cell || adult pacemaker neuron || LNv neuron || cardioblast || embryonic cardioblast || longitudinal muscle || embryonic somatic muscle || s-LNv neuron || LN period neuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2027 | INHERITED FROM: eo neuron |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.347 | INHERITED FROM: bouton || synapse |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.347 | INHERITED FROM: flight muscle || adult somatic muscle || skeletal muscle of thorax || skeletal muscle of mesothorax || muscle cell || syncytium || somatic muscle |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.347 | INHERITED FROM: photoreceptor cell R7 || inner photoreceptor cell |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.358 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4363 | INHERITED FROM: larval abdominal sensory neuron || abdominal neuron || dendritic arborizing neuron || multidendritic neuron |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.5103 | INHERITED FROM: pacemaker neuron || gustatory receptor neuron || mechanosensory neuron || adult pacemaker neuron || LNv neuron || chemosensory neuron || giant fiber neuron || chemosensory system neuron || adult descending neuron || neuropil associated CNS glial cell || s-LNv neuron || LN period neuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.565 | INHERITED FROM: mechanosensory system neuron || mechanosensory neuron |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.6631 | INHERITED FROM: female germline cell |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.7368 | INHERITED FROM: 5-6I of thorax || 5-6I || EL neuron || EG neuron || thoracic neuron |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.7379 | INHERITED FROM: bouton |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.8259 | INHERITED FROM: head mesoderm derived embryonic hemocyte || photoreceptor cell R7 || pigment cell || inner photoreceptor cell || crystal cell || somatic cell of testis || hub cell || embryonic hemocyte |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: embryonic ganglion mother cell |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | Direct |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | Direct |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.117 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1361 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2027 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.347 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.347 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.347 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.358 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4363 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.5103 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.565 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.6631 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.7368 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.7379 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.8259 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04015 | INHERITED FROM: rhabdomeric photoreceptor cell || head mesoderm derived embryonic hemocyte || embryonic/larval pericardial cell || adult optic lobe neuron || embryonic/larval somatic muscle || sensory neuron || embryonic/larval hypodermal muscle || sensory organ cell || eye photoreceptor cell stalk || pericardial cell || histaminergic neuron || glial cell || secondary pigment cell || nephrocyte || photoreceptor cell R6 || somatic cell of testis || hub cell || photoreceptor cell R1 || embryonic hemocyte || tertiary pigment cell |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2917 | INHERITED FROM: mechanosensory system neuron || pacemaker neuron || gustatory receptor neuron || mechanosensory neuron || adult pacemaker neuron || LNv neuron || chemosensory neuron || giant fiber neuron || eo neuron || chemosensory system neuron || adult descending neuron || neuropil associated CNS glial cell || s-LNv neuron || LN period neuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3507 | INHERITED FROM: pacemaker neuron || interommatidial precursor cell || gustatory receptor neuron || adult pacemaker neuron || LNv neuron || embryonic cardioblast || embryonic/larval garland cell || s-LNv neuron || interneuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.358 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: embryonic ganglion mother cell |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04015 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2917 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3507 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.358 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Download Newick format tree:
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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