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Fly Anatomy (FA): organism subdivision
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (Not in SDFA)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Myb/SANT domain | 0 | DIRECT |
RNase III catalytic domain-like | 0 | DIRECT |
ets domain | 0 | DIRECT |
FHA domain | 0 | DIRECT |
Paired domain | 0 | DIRECT |
BC ATP-binding domain-like | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
Third domain of FERM | 0 | DIRECT |
p120GAP domain-like | 0 | DIRECT |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
First domain of FERM | 0 | DIRECT |
A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
Dachshund-homology domain | 0 | DIRECT |
Fibroblast growth factors (FGF) | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
N-acetyl transferase, NAT | 0 | DIRECT |
Frizzled cysteine-rich domain | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
VHS domain | 0 | DIRECT |
ARID domain | 0 | DIRECT |
ZZ domain | 0 | DIRECT |
Diacylglycerol kinase-like | 0 | DIRECT |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
BC N-terminal domain-like | 0 | DIRECT |
Histone deacetylase, HDAC | 0 | DIRECT |
Sema domain | 0 | DIRECT |
Hairy Orange domain | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
Laminin-type module | 0 | DIRECT |
POU-specific domain | 0 | DIRECT |
Rhomboid-like | 0 | DIRECT |
Chromo barrel domain | 0 | DIRECT |
Smc hinge domain | 0 | DIRECT |
SAP domain | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
Pepsin-like | 0 | DIRECT |
Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
cAMP-binding domain | 0 | DIRECT |
Second domain of FERM | 0 | DIRECT |
Arrestin/Vps26-like | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
MIR domain | 0 | DIRECT |
Homeodomain | 0.0000000000002066 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.00000001977 | DIRECT |
Classic zinc finger, C2H2 | 0.0005487 | DIRECT |
Protein kinases, catalytic subunit | 0.0008084 | DIRECT |
Fibronectin type III | 0.006983 | INHERITED FROM: LN period neuron || larval tagma || LNv neuron || lobe system of adult mushroom body || procephalic segment || s-LNv neuron || larval abdomen |
Laminin G-like module | 0.02511 | INHERITED FROM: procephalic segment || photoreceptor cell R4 |
Nuclear receptor ligand-binding domain | 0.02601 | INHERITED FROM: mushroom body gamma-lobe || procephalic segment || protocerebrum |
I set domains | 0.03961 | INHERITED FROM: head segment || adult cerebral ganglion || LNv neuron || lobe system of adult mushroom body || procephalic segment || adult brain || adult head segment || s-LNv neuron || larval abdomen |
Nuclear receptor | 0.03961 | INHERITED FROM: mushroom body gamma-lobe || larval abdominal neuromere || abdominal neuromere |
SH2 domain | 0.0405 | INHERITED FROM: adult segment || head sensillum || photoreceptor cell R7 || ommatidium |
HMG-box | 0.06687 | INHERITED FROM: adult mesothoracic segment || adult thorax || adult external thorax || adult thoracic segment || wing |
Histone lysine methyltransferases | 0.07009 | INHERITED FROM: dorsal thoracic disc || adult metathoracic segment || haltere || metathoracic leg |
Transforming growth factor (TGF)-beta | 0.09782 | INHERITED FROM: embryonic/larval posterior spiracle || stigmatophore |
Calponin-homology domain, CH-domain | 0.1103 | INHERITED FROM: indirect flight muscle || abdominal segmental nerve || flight muscle |
Cytochrome P450 | 0.1114 | INHERITED FROM: embryonic head |
Plexin repeat | 0.1358 | INHERITED FROM: abdominal segment || larval abdominal segment || abdomen || abdominal nerve || larval abdomen |
Ngr ectodomain-like | 0.1463 | INHERITED FROM: intersegmental nerve branch ISNb of A1-7 || intersegmental nerve of A1-7 || abdominal intersegmental nerve |
SMAD domain | 0.1905 | INHERITED FROM: dorsal thoracic disc || larval mesothoracic segment || wing vein || larval thoracic segment || abdominal segment || wing blade || larval thorax || wing disc |
SAM (sterile alpha motif) domain | 0.2473 | INHERITED FROM: prothoracic leg || adult metathoracic segment || metatarsus of male prothoracic leg || prothoracic tarsal segment || adult prothoracic segment || prothoracic metatarsus || sex comb || adult abdominal segment 4 || metatarsus || mesothoracic leg |
Cadherin | 0.2473 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell || wing hair |
EGF-type module | 0.2567 | INHERITED FROM: adult external head || adult antennal segment || wing blade |
Choline/Carnitine O-acyltransferase | 0.2647 | INHERITED FROM: skeletal muscle of mesothorax || flight muscle || skeletal muscle of thorax |
BTB/POZ domain | 0.3126 | INHERITED FROM: adult antennal segment || prothoracic tarsal segment || adult abdominal segment |
Growth factor receptor domain | 0.3413 | INHERITED FROM: ocellar triangle || ocellus || tibia |
PLC-like (P variant) | 0.5099 | INHERITED FROM: mesothoracic tergum |
G proteins | 1 | INHERITED FROM: wing hair |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Myb/SANT domain | 0 | Direct |
RNase III catalytic domain-like | 0 | Direct |
ets domain | 0 | Direct |
FHA domain | 0 | Direct |
Paired domain | 0 | Direct |
BC ATP-binding domain-like | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
Third domain of FERM | 0 | Direct |
p120GAP domain-like | 0 | Direct |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
First domain of FERM | 0 | Direct |
A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
Dachshund-homology domain | 0 | Direct |
Fibroblast growth factors (FGF) | 0 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
N-acetyl transferase, NAT | 0 | Direct |
Frizzled cysteine-rich domain | 0 | Direct |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Class I glutamine amidotransferases (GAT) | 0 | Direct |
Ubiquitin activating enzymes (UBA) | 0 | Direct |
VHS domain | 0 | Direct |
ARID domain | 0 | Direct |
ZZ domain | 0 | Direct |
Diacylglycerol kinase-like | 0 | Direct |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
BC N-terminal domain-like | 0 | Direct |
Histone deacetylase, HDAC | 0 | Direct |
Sema domain | 0 | Direct |
Hairy Orange domain | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
Laminin-type module | 0 | Direct |
POU-specific domain | 0 | Direct |
Rhomboid-like | 0 | Direct |
Chromo barrel domain | 0 | Direct |
Smc hinge domain | 0 | Direct |
SAP domain | 0 | Direct |
Integrin domains | 0 | Direct |
Pepsin-like | 0 | Direct |
Cell cycle control phosphatase, catalytic domain | 0 | Direct |
Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
cAMP-binding domain | 0 | Direct |
Second domain of FERM | 0 | Direct |
Arrestin/Vps26-like | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
MIR domain | 0 | Direct |
Homeodomain | 0.0000000000002066 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.00000001977 | Direct |
Classic zinc finger, C2H2 | 0.0005487 | Direct |
Protein kinases, catalytic subunit | 0.0008084 | Direct |
Fibronectin type III | 0.006983 | Inherited |
Laminin G-like module | 0.02511 | Inherited |
Nuclear receptor ligand-binding domain | 0.02601 | Inherited |
I set domains | 0.03961 | Inherited |
Nuclear receptor | 0.03961 | Inherited |
SH2 domain | 0.0405 | Inherited |
HMG-box | 0.06687 | Inherited |
Histone lysine methyltransferases | 0.07009 | Inherited |
Transforming growth factor (TGF)-beta | 0.09782 | Inherited |
Calponin-homology domain, CH-domain | 0.1103 | Inherited |
Cytochrome P450 | 0.1114 | Inherited |
Plexin repeat | 0.1358 | Inherited |
Ngr ectodomain-like | 0.1463 | Inherited |
SMAD domain | 0.1905 | Inherited |
SAM (sterile alpha motif) domain | 0.2473 | Inherited |
Cadherin | 0.2473 | Inherited |
EGF-type module | 0.2567 | Inherited |
Choline/Carnitine O-acyltransferase | 0.2647 | Inherited |
BTB/POZ domain | 0.3126 | Inherited |
Growth factor receptor domain | 0.3413 | Inherited |
PLC-like (P variant) | 0.5099 | Inherited |
G proteins | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0 | DIRECT |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | DIRECT |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0 | DIRECT |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | DIRECT |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | DIRECT |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | DIRECT |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0 | DIRECT |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0 | DIRECT |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | DIRECT |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0 | DIRECT |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like | 0 | DIRECT |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.000000131 | DIRECT |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.02351 | INHERITED FROM: lobe system of adult mushroom body || adult antennal lobe glomerulus || LN period neuron || adult antennal lobe || s-LNv neuron || LNv neuron |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.02628 | INHERITED FROM: lobe system of adult mushroom body || adult head segment || head segment || procephalic segment || LN period neuron || s-LNv neuron || adult brain || adult cerebral ganglion || larval abdomen || LNv neuron |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.08989 | INHERITED FROM: abdominal neuron || larval abdomen || lamina |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1107 | INHERITED FROM: secondary pigment cell || wing blade dorsal compartment || tertiary pigment cell || ocellus || frons || joint || postfrons || eye photoreceptor cell stalk || intersegmental nerve branch ISNb of A1-7 |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.1265 | INHERITED FROM: mesothoracic bristle || adult mesothoracic sensillum || inner photoreceptor cell || wing blade dorsal compartment || scutum || adult thoracic sensillum || photoreceptor cell R7 || leg || joint || wing vein || abdomen || interommatidial bristle |
81296,81296 81296 - E set domains 81296 - E set domains | 0.1791 | INHERITED FROM: abdominal nerve || abdominal segmental nerve || abdominal intersegmental nerve |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.2299 | INHERITED FROM: outer photoreceptor cell || wing hair || photoreceptor cell R4 |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2299 | INHERITED FROM: adult labral segment || adult protocerebrum |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.2543 | INHERITED FROM: larval abdominal segment || abdominal nerve || abdominal segmental nerve || larval abdomen |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.2543 | INHERITED FROM: flight muscle || skeletal muscle of mesothorax || skeletal muscle of thorax |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.2733 | INHERITED FROM: dorsal thoracic disc posterior compartment || bristle of mesothoracic tergum || wing disc posterior compartment |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0 | Direct |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | Direct |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0 | Direct |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | Direct |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | Direct |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | Direct |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | Direct |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | Direct |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0 | Direct |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0 | Direct |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | Direct |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0 | Direct |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like | 0 | Direct |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.000000131 | Direct |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.02351 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.02628 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.08989 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1107 | Inherited |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.1265 | Inherited |
81296,81296 81296 - E set domains 81296 - E set domains | 0.1791 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.2299 | Inherited |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2299 | Inherited |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.2543 | Inherited |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.2543 | Inherited |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.2733 | Inherited |
(show details)
Supra-domains annotated to this FA term (Not in SPFA)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0 | DIRECT |
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains | 0 | DIRECT |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0 | DIRECT |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.00006395 | DIRECT |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.01475 | INHERITED FROM: abdominal segment || secondary pigment cell || larval segment || larval tagma || wing blade dorsal compartment || tertiary pigment cell || photoreceptor cell R1 || photoreceptor cell R6 || adult head sensillum || ocellus || frons || joint || postfrons || eye photoreceptor cell stalk || ocellar triangle || adult external head |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.01526 | INHERITED FROM: lobe system of adult mushroom body || adult antennal lobe glomerulus || LN period neuron || adult antennal lobe || s-LNv neuron || LNv neuron |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1252 | INHERITED FROM: lobe system of adult mushroom body || head segment || procephalic segment || s-LNv neuron || adult brain || LNv neuron |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.2299 | INHERITED FROM: outer photoreceptor cell || wing hair || photoreceptor cell R4 |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0 | Direct |
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains | 0 | Direct |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0 | Direct |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.00006395 | Direct |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.01475 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.01526 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1252 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.2299 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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