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Fly Anatomy (FA): organ system subdivision
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (SDFA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Dachshund-homology domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| PX domain | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Serpins | 0 | DIRECT |
| Synaptotagmin-like (S variant) | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| SPRY domain | 0 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
| Forkhead DNA-binding domain | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| Transforming growth factor (TGF)-beta | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| L-arabinose binding protein-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Homeodomain | 0.0000000000006665 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.000004491 | DIRECT |
| Fibronectin type III | 0.000355 | DIRECT |
| Protein kinases, catalytic subunit | 0.0009293 | DIRECT |
| Classic zinc finger, C2H2 | 0.00301 | INHERITED FROM: region of integument |
| SH2 domain | 0.00652 | INHERITED FROM: midline crossing tract || ommatidium || adult peripheral nervous system || photoreceptor cell R7 |
| Nuclear receptor ligand-binding domain | 0.008292 | INHERITED FROM: synaptic neuropil || synaptic neuropil block || central brain || mushroom body gamma-lobe || supraesophageal ganglion neuron || protocerebrum || neuropil |
| Nuclear receptor | 0.02051 | INHERITED FROM: synaptic neuropil || synaptic neuropil block || mushroom body gamma-lobe || supraesophageal ganglion neuron || abdominal neuromere || larval abdominal neuromere |
| HMG-box | 0.03456 | INHERITED FROM: region of integument || adult external thorax || wing |
| Ngr ectodomain-like | 0.05331 | INHERITED FROM: intersegmental nerve branch ISNb of A1-7 || abdominal intersegmental nerve || intersegmental nerve of A1-7 |
| Paired domain | 0.05331 | INHERITED FROM: EG neuron || RP2 motor neuron || EL neuron |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.05331 | INHERITED FROM: intersegmental nerve |
| I set domains | 0.06878 | INHERITED FROM: interface glial cell || segmental subdivision of organ system || synaptic neuropil || lobe system of adult mushroom body || antennal lobe glomerulus || synaptic neuropil subdomain || commissure || adult cerebral ganglion || synaptic neuropil block || LNv neuron || connective || neuropil glial sheath || adult central nervous system || s-LNv neuron || gustatory receptor neuron || leg taste bristle chemosensory neuron || tract neuropil || adult brain |
| PLC-like (P variant) | 0.09608 | INHERITED FROM: mesothoracic tergum || larval dorsal multidendritic neuron ddaC || larval dorsal multidendritic neuron |
| Histone lysine methyltransferases | 0.09608 | INHERITED FROM: metathoracic leg || haltere |
| BTB/POZ domain | 0.1339 | INHERITED FROM: prothoracic tarsal segment |
| Laminin G-like module | 0.1552 | INHERITED FROM: photoreceptor cell R4 |
| Transducin (alpha subunit), insertion domain | 0.1721 | INHERITED FROM: eo neuron |
| Toll/Interleukin receptor TIR domain | 0.1721 | INHERITED FROM: ventral nerve cord |
| SMAD domain | 0.231 | INHERITED FROM: wing blade || wing vein || gut section |
| Ankyrin repeat | 0.2359 | INHERITED FROM: ventral multidendritic neuron |
| Spectrin repeat | 0.2467 | INHERITED FROM: tract || middle midgut || connective || midgut epithelium || longitudinal connective || ipsilateral tract || copper cell |
| SAM (sterile alpha motif) domain | 0.3085 | INHERITED FROM: prothoracic leg || mesothoracic leg || metatarsus || sex comb || metatarsus of male prothoracic leg || prothoracic metatarsus || prothoracic tarsal segment |
| Calponin-homology domain, CH-domain | 0.3274 | INHERITED FROM: abdominal segmental nerve |
| Cytochrome P450 | 0.3531 | INHERITED FROM: midline glial cell || hindgut || midline crossing tract || commissure || tract || neuropil glial sheath || neuropil associated CNS glial cell || CNS glial cell || midgut || larval neuropil glial cell || tract neuropil || embryonic/larval foregut || larval VNC neuropil glial cell || embryonic/larval hindgut |
| Cyclin | 0.3896 | INHERITED FROM: tagmatic subdivision of organ system |
| Growth factor receptor domain | 0.4227 | INHERITED FROM: salivary gland || ocellus || hindgut || proventriculus || integumentary specialisation || ocellar triangle || tibia |
| EGF-type module | 0.5404 | INHERITED FROM: wing blade || embryonic/larval midgut cell || hindgut || proventriculus || adult midgut progenitor cell || adult external head || ventral nervous system |
| Ubiquitin-related | 0.5594 | INHERITED FROM: mushroom body extrinsic neuron |
| Cadherin | 0.5903 | INHERITED FROM: wing hair || outer photoreceptor cell || photoreceptor cell R4 |
| G proteins | 0.9379 | INHERITED FROM: wing hair |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Dachshund-homology domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| PX domain | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Serpins | 0 | Direct |
| Synaptotagmin-like (S variant) | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| SPRY domain | 0 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
| Forkhead DNA-binding domain | 0 | Direct |
| ARID domain | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| Transforming growth factor (TGF)-beta | 0 | Direct |
| Sema domain | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| L27 domain | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Laminin-type module | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| SAP domain | 0 | Direct |
| L-arabinose binding protein-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| Pepsin-like | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| Cullin repeat | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Homeodomain | 0.0000000000006665 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.000004491 | Direct |
| Fibronectin type III | 0.000355 | Direct |
| Protein kinases, catalytic subunit | 0.0009293 | Direct |
| Classic zinc finger, C2H2 | 0.00301 | Inherited |
| SH2 domain | 0.00652 | Inherited |
| Nuclear receptor ligand-binding domain | 0.008292 | Inherited |
| Nuclear receptor | 0.02051 | Inherited |
| HMG-box | 0.03456 | Inherited |
| Ngr ectodomain-like | 0.05331 | Inherited |
| Paired domain | 0.05331 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.05331 | Inherited |
| I set domains | 0.06878 | Inherited |
| PLC-like (P variant) | 0.09608 | Inherited |
| Histone lysine methyltransferases | 0.09608 | Inherited |
| BTB/POZ domain | 0.1339 | Inherited |
| Laminin G-like module | 0.1552 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.1721 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.1721 | Inherited |
| SMAD domain | 0.231 | Inherited |
| Ankyrin repeat | 0.2359 | Inherited |
| Spectrin repeat | 0.2467 | Inherited |
| SAM (sterile alpha motif) domain | 0.3085 | Inherited |
| Calponin-homology domain, CH-domain | 0.3274 | Inherited |
| Cytochrome P450 | 0.3531 | Inherited |
| Cyclin | 0.3896 | Inherited |
| Growth factor receptor domain | 0.4227 | Inherited |
| EGF-type module | 0.5404 | Inherited |
| Ubiquitin-related | 0.5594 | Inherited |
| Cadherin | 0.5903 | Inherited |
| G proteins | 0.9379 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0 | DIRECT |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.000003009 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01269 | INHERITED FROM: s-LNv neuron || synaptic neuropil block || segmental subdivision of organ system || synaptic neuropil || LN period neuron || leg taste bristle chemosensory neuron || connective || lobe system of adult mushroom body || tract neuropil || antennal lobe glomerulus || LNv neuron || central nervous system || adult cerebral ganglion || neuropil glial sheath || commissure || adult brain |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.04231 | INHERITED FROM: s-LNv neuron || adult antennal lobe || LN period neuron || leg taste bristle chemosensory neuron || adult antennal lobe glomerulus || connective || lobe system of adult mushroom body || tract neuropil || antennal lobe glomerulus || neuropil associated CNS glial cell || LNv neuron || giant fiber neuron || neuropil glial sheath || commissure || gustatory receptor neuron |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.06191 | INHERITED FROM: photoreceptor cell R4 || peripheral nervous system |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.08471 | INHERITED FROM: copper cell || connective || tract neuropil || midgut epithelium || longitudinal connective || tract || adult protocerebrum || ipsilateral tract || middle midgut |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1579 | INHERITED FROM: intersegmental nerve || proventriculus || scutum || wing blade dorsal compartment || inner photoreceptor cell || wing vein || leg || joint || photoreceptor cell R7 || integumentary specialisation |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1579 | INHERITED FROM: sclerite |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1579 | INHERITED FROM: eo neuron |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.1988 | INHERITED FROM: bristle of mesothoracic tergum |
81296,81296
81296 - E set domains
81296 - E set domains | 0.2154 | INHERITED FROM: abdominal segmental nerve || intersegmental nerve || abdominal nerve || segmental nerve || abdominal intersegmental nerve |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.2924 | INHERITED FROM: abdominal segmental nerve || intersegmental nerve || abdominal nerve || segmental nerve || embryonic/larval peripheral nervous system || nerve |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0.2924 | INHERITED FROM: embryonic/larval peripheral nervous system |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3073 | INHERITED FROM: tertiary pigment cell || proventriculus || wing blade dorsal compartment || secondary pigment cell || intersegmental nerve branch ISNb of A1-7 || eye photoreceptor cell stalk || ventral nervous system || postfrons || joint || frons || ocellus |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3577 | INHERITED FROM: integumentary specialisation |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.5592 | INHERITED FROM: wing hair || outer photoreceptor cell || photoreceptor cell R4 |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0 | Direct |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.000003009 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01269 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.04231 | Inherited |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.06191 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.08471 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1579 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1579 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1579 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.1988 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.2154 | Inherited |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.2924 | Inherited |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0.2924 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3073 | Inherited |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3577 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.5592 | Inherited |
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.00007977 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06563 | INHERITED FROM: s-LNv neuron || synaptic neuropil block || segmental subdivision of organ system || synaptic neuropil || leg taste bristle chemosensory neuron || connective || lobe system of adult mushroom body || tract neuropil || LNv neuron || central nervous system || commissure || adult brain || gustatory receptor neuron |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.08725 | INHERITED FROM: s-LNv neuron || adult antennal lobe || LN period neuron || leg taste bristle chemosensory neuron || adult antennal lobe glomerulus || connective || lobe system of adult mushroom body || antennal lobe glomerulus || neuropil associated CNS glial cell || LNv neuron || giant fiber neuron || eo neuron || embryonic/larval central nervous system || neuropil glial sheath || gustatory receptor neuron |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1044 | INHERITED FROM: photoreceptor cell R6 || photoreceptor cell R1 || tertiary pigment cell || proventriculus || wing blade dorsal compartment || secondary pigment cell || adult external head || eye photoreceptor cell stalk || ventral nervous system || ocellar triangle || postfrons || joint || frons || ocellus |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2154 | INHERITED FROM: intersegmental nerve || bristle of mesothoracic tergum || dorsal mesothorax || scutum || tergum || adult external mesothorax || adult thoracic mechanosensory chaeta || mesothoracic tergum || nerve || integumentary specialisation |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.5592 | INHERITED FROM: wing hair || outer photoreceptor cell || photoreceptor cell R4 |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.00007977 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06563 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.08725 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.1044 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2154 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.5592 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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