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Fly Anatomy (FA): somatic cell
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this FA term (Not in SDFA)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (SDFA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Isoprenyl diphosphate synthases | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| CAD domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
| beta-CASP RNA-metabolising hydrolases | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Transforming growth factor (TGF)-beta | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Tetramerization domain of potassium channels | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| Mob1/phocein | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| SAP domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Spectrin repeat | 0.05747 | INHERITED FROM: fat cell || enterocyte || copper cell |
| I set domains | 0.1238 | INHERITED FROM: cardioblast || LNv neuron || embryonic/larval lateral glial cell || interface glial cell || visceral muscle fiber || adult descending neuron || pacemaker neuron || mechanosensory system neuron || gustatory system neuron || adult pacemaker neuron || gustatory receptor neuron || embryonic heart cardioblast || s-LNv neuron || larval abdominal sensory neuron || embryonic cardioblast || embryonic somatic muscle || leg taste bristle chemosensory neuron |
| Calponin-homology domain, CH-domain | 0.128 | INHERITED FROM: indirect flight muscle || flight muscle |
| Homeodomain | 0.1454 | INHERITED FROM: thoracic neuroblast || ventral intersegmental muscle || hypodermal muscle of prothorax || dorsal margin photoreceptor || interneuron || maxillary palp olfactory receptor neuron || EL neuron || A1-7 ventral acute muscle 1 || uniglomerular antennal lobe projection neuron || embryonic/larval neuron || prothoracic ventral intersegmental muscle || U neuron || embryonic neuroblast |
| Transducin (alpha subunit), insertion domain | 0.1493 | INHERITED FROM: eo neuron |
| PDZ domain | 0.1579 | INHERITED FROM: somatic cell of ovariole |
| ZZ domain | 0.2053 | INHERITED FROM: skeletal muscle of mesothorax || indirect flight muscle || adult somatic muscle || skeletal muscle of thorax || flight muscle |
| Fibronectin type III | 0.2687 | INHERITED FROM: LNv neuron || LN period neuron || pacemaker neuron || adult pacemaker neuron || gustatory receptor neuron || embryonic heart cardioblast || s-LNv neuron |
| Cadherin | 0.2696 | INHERITED FROM: outer photoreceptor cell || photoreceptor cell R4 |
| PLC-like (P variant) | 0.2696 | INHERITED FROM: larval dorsal multidendritic neuron ddaC || head mesoderm derived embryonic hemocyte || larval dorsal multidendritic neuron |
| HLH, helix-loop-helix DNA-binding domain | 0.2795 | INHERITED FROM: EL neuron || 5-6I of thorax || sensory mother cell |
| Cap-Gly domain | 0.2811 | INHERITED FROM: interneuron |
| Choline/Carnitine O-acyltransferase | 0.2811 | INHERITED FROM: skeletal muscle of mesothorax || adult somatic muscle || skeletal muscle of thorax || somatic muscle || flight muscle |
| Protein kinases, catalytic subunit | 0.2919 | INHERITED FROM: photoreceptor cell R8 of pale ommatidium || intestinal stem cell || somatic cell of ovariole |
| Ankyrin repeat | 0.3577 | INHERITED FROM: ventral multidendritic neuron || Johnston organ neuron |
| Paired domain | 0.37 | INHERITED FROM: RP2 motor neuron || EG neuron || EL neuron || U neuron |
| Caspase catalytic domain | 0.4324 | INHERITED FROM: peptidergic neuron |
| EGF-type module | 0.475 | INHERITED FROM: adult midgut progenitor cell || pigment cell || dorsal acute muscle || head mesoderm derived embryonic hemocyte || embryonic pericardial cell || hub cell |
| Cytochrome P450 | 0.5379 | INHERITED FROM: embryonic/larval glial cell || midline glial cell || CNS glial cell || neuropil associated CNS glial cell || larval neuropil glial cell || larval VNC neuropil glial cell |
| Nuclear receptor | 0.5896 | INHERITED FROM: interneuron || mushroom body intrinsic neuron || supraesophageal ganglion neuron |
| Nuclear receptor ligand-binding domain | 0.5978 | INHERITED FROM: interneuron || mushroom body intrinsic neuron || supraesophageal ganglion neuron |
| Growth factor receptor domain | 0.6217 | INHERITED FROM: somatic cell of testis || embryonic hemocyte || head mesoderm derived embryonic hemocyte |
| G proteins | 0.6582 | INHERITED FROM: hemocyte |
| SH2 domain | 0.6858 | INHERITED FROM: rhabdomeric photoreceptor cell || photoreceptor cell || adult optic lobe neuron || sensory organ cell || cyst progenitor cell || photoreceptor cell R7 || histaminergic neuron |
| Hairy Orange domain | 0.7078 | INHERITED FROM: EG neuron || EL neuron |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.7247 | INHERITED FROM: intestinal stem cell |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.7628 | INHERITED FROM: garland cell || embryonic/larval garland cell |
| Forkhead DNA-binding domain | 0.8672 | INHERITED FROM: RP2sib neuron |
| Ubiquitin-related | 0.928 | INHERITED FROM: mushroom body extrinsic neuron |
| Tubulin, GTPase domain | 0.9503 | INHERITED FROM: type II neuroblast || fat cell || type I neuroblast |
| Tubulin, C-terminal domain | 0.9704 | INHERITED FROM: type II neuroblast || fat cell || type I neuroblast |
| Classic zinc finger, C2H2 | 1 | INHERITED FROM: embryonic ganglion mother cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Myb/SANT domain | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Isoprenyl diphosphate synthases | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| CAD domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
| beta-CASP RNA-metabolising hydrolases | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Pointed domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Transforming growth factor (TGF)-beta | 0 | Direct |
| Sema domain | 0 | Direct |
| Laminin-type module | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Tetramerization domain of potassium channels | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| Mob1/phocein | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| SAP domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Prefoldin | 0 | Direct |
| MIR domain | 0 | Direct |
| Spectrin repeat | 0.05747 | Inherited |
| I set domains | 0.1238 | Inherited |
| Calponin-homology domain, CH-domain | 0.128 | Inherited |
| Homeodomain | 0.1454 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.1493 | Inherited |
| PDZ domain | 0.1579 | Inherited |
| ZZ domain | 0.2053 | Inherited |
| Fibronectin type III | 0.2687 | Inherited |
| Cadherin | 0.2696 | Inherited |
| PLC-like (P variant) | 0.2696 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.2795 | Inherited |
| Cap-Gly domain | 0.2811 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.2811 | Inherited |
| Protein kinases, catalytic subunit | 0.2919 | Inherited |
| Ankyrin repeat | 0.3577 | Inherited |
| Paired domain | 0.37 | Inherited |
| Caspase catalytic domain | 0.4324 | Inherited |
| EGF-type module | 0.475 | Inherited |
| Cytochrome P450 | 0.5379 | Inherited |
| Nuclear receptor | 0.5896 | Inherited |
| Nuclear receptor ligand-binding domain | 0.5978 | Inherited |
| Growth factor receptor domain | 0.6217 | Inherited |
| G proteins | 0.6582 | Inherited |
| SH2 domain | 0.6858 | Inherited |
| Hairy Orange domain | 0.7078 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.7247 | Inherited |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.7628 | Inherited |
| Forkhead DNA-binding domain | 0.8672 | Inherited |
| Ubiquitin-related | 0.928 | Inherited |
| Tubulin, GTPase domain | 0.9503 | Inherited |
| Tubulin, C-terminal domain | 0.9704 | Inherited |
| Classic zinc finger, C2H2 | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | DIRECT |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | DIRECT |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.04026 | INHERITED FROM: pacemaker neuron || interommatidial precursor cell || adult pacemaker neuron || LNv neuron || cardioblast || longitudinal muscle || embryonic cardioblast || embryonic somatic muscle || s-LNv neuron || LN period neuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1416 | INHERITED FROM: eo neuron |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.2557 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.2724 | INHERITED FROM: bouton || synapse |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.2724 | INHERITED FROM: flight muscle || adult somatic muscle || skeletal muscle of thorax || skeletal muscle of mesothorax || muscle cell || somatic muscle |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.2724 | INHERITED FROM: photoreceptor cell R7 || inner photoreceptor cell |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3221 | INHERITED FROM: pacemaker neuron || gustatory receptor neuron || mechanosensory neuron || adult pacemaker neuron || LNv neuron || chemosensory neuron || giant fiber neuron || chemosensory system neuron || adult descending neuron || neuropil associated CNS glial cell || s-LNv neuron || LN period neuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.3274 | INHERITED FROM: abdominal neuron || larval abdominal sensory neuron || dendritic arborizing neuron || multidendritic neuron |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.4304 | INHERITED FROM: mechanosensory system neuron || mechanosensory neuron |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.6009 | INHERITED FROM: 5-6I of thorax || 5-6I || EL neuron || EG neuron || thoracic neuron |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.624 | INHERITED FROM: bouton |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.7309 | INHERITED FROM: head mesoderm derived embryonic hemocyte || photoreceptor cell R7 || pigment cell || inner photoreceptor cell || crystal cell || somatic cell of testis || hub cell || embryonic hemocyte |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.7691 | INHERITED FROM: rhabdomeric photoreceptor cell || embryonic/larval pericardial cell || embryonic/larval somatic muscle || sensory organ cell || eye photoreceptor cell stalk || pericardial cell || secondary pigment cell || nephrocyte || hub cell || tertiary pigment cell |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.9676 | INHERITED FROM: fat cell || type II neuroblast || type I neuroblast |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: embryonic ganglion mother cell |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | Direct |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | Direct |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.04026 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1416 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.2557 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.2724 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.2724 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.2724 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3221 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.3274 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.4304 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.6009 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.624 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.7309 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.7691 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.9676 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01863 | INHERITED FROM: rhabdomeric photoreceptor cell || embryonic/larval pericardial cell || head mesoderm derived embryonic hemocyte || adult optic lobe neuron || embryonic/larval somatic muscle || sensory neuron || embryonic/larval hypodermal muscle || sensory organ cell || eye photoreceptor cell stalk || pericardial cell || histaminergic neuron || glial cell || secondary pigment cell || nephrocyte || photoreceptor cell R6 || somatic cell of testis || hub cell || photoreceptor cell R1 || embryonic hemocyte || tertiary pigment cell |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1628 | INHERITED FROM: pacemaker neuron || interommatidial precursor cell || gustatory receptor neuron || adult pacemaker neuron || LNv neuron || embryonic cardioblast || embryonic/larval garland cell || s-LNv neuron || interneuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1668 | INHERITED FROM: mechanosensory system neuron || pacemaker neuron || gustatory receptor neuron || mechanosensory neuron || adult pacemaker neuron || LNv neuron || chemosensory neuron || giant fiber neuron || eo neuron || chemosensory system neuron || adult descending neuron || neuropil associated CNS glial cell || s-LNv neuron || LN period neuron || embryonic heart cardioblast || leg taste bristle chemosensory neuron |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.2557 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: embryonic ganglion mother cell |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01863 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1628 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1668 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.2557 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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