Fly Phenotype (FP): increased mortality

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: FP Hierarchy (fly phenotype from FlyBase controlled vocabulary with sub-ontology "phenotypic class")

Shortest distance to current term (+ for parents, - for children) FP term [FP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: phenotypic class [FBcv:0000347] <4>

+ 1: phenotype [FBcv:0001347] <62> (177|209) (176|83|29)

0: increased mortality [FBcv:0002004] <2> (55|71) (55|19|7)

- 1: increased mortality during development [FBcv:0002019] <6> (42|59) (42|14|6)

- 1: short lived [FBcv:0000385] (3|3) (3|2|1)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
GINS helical bundle-like	0	Direct
ACT-like	0	Direct
SMAD MH1 domain	0	Direct
Ferritin-like	0	Direct
Class II aaRS ABD-related	0	Direct
Cytokine	0	Direct
Subtilisin-like	0	Direct
lambda repressor-like DNA-binding domains	0	Direct
Zn-binding ribosomal proteins	0	Direct
Zinc beta-ribbon	0	Direct
Smc hinge domain	0	Direct
ARID-like	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
Succinyl-CoA synthetase domains	0	Direct
SAND domain-like	0	Direct
Class I glutamine amidotransferase-like	0	Direct
Terpenoid synthases	0	Direct
RNase III domain-like	0	Direct
DEK C-terminal domain	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
PIN domain-like	0	Direct
S15/NS1 RNA-binding domain	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Nop domain	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Putative DNA-binding domain	0	Direct
KA1-like	0	Direct
Isocitrate/Isopropylmalate dehydrogenase-like	0	Direct
ACP-like	0	Direct
B-box zinc-binding domain	0	Direct
PriA/YqbF domain	0	Direct
Aldolase	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Formin homology 2 domain (FH2 domain)	0	Direct
Ribonuclease PH domain 2-like	0	Direct
Clathrin adaptor appendage domain	0	Direct
SMAD/FHA domain	0	Direct
Sec1/munc18-like (SM) proteins	0	Direct
HR1 repeat	0	Direct
E2F-DP heterodimerization region	0	Direct
Tetrahydrobiopterin biosynthesis enzymes-like	0	Direct
HSP90 C-terminal domain	0	Direct
Leucine zipper domain	0.000833	Direct
SNARE fusion complex	0.003864	Inherited
RNA-binding domain, RBD	0.007584	Inherited
ARM repeat	0.02597	Inherited
Nuclear receptor ligand-binding domain	0.06008	Inherited
Homeodomain-like	0.06469	Inherited
Protein kinase-like (PK-like)	0.07311	Inherited
beta-sandwich domain of Sec23/24	0.07455	Inherited
Spectrin repeat	0.1053	Inherited
Snake toxin-like	0.1791	Inherited
EGF/Laminin	0.4326	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Single strand DNA-binding domain, SSB	0	Direct
Hsp90 middle domain	0	Direct
beta-CASP RNA-metabolising hydrolases	0	Direct
Fibroblast growth factors (FGF)	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
a tRNA synthase domain	0	Direct
Anticodon-binding domain of Class II aaRS	0	Direct
Extracellular domain of cell surface receptors	0	Direct
Heat shock protein 90, HSP90, N-terminal domain	0	Direct
Ribonuclease PH domain 2-like	0	Direct
IF2B-like	0	Direct
Clathrin adaptor core protein	0	Direct
Smc hinge domain	0	Direct
Laminin-type module	0	Direct
Class I glutamine amidotransferases (GAT)	0	Direct
Meta-cation ATPase, catalytic domain P	0	Direct
Diap1 N-terninal region-like	0	Direct
POU-specific domain	0	Direct
MBT repeat	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
Dachshund-homology domain	0	Direct
Nop domain	0	Direct
Transcriptional factor domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
FHA domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0	Direct
Chromo barrel domain	0	Direct
Acyl-carrier protein (ACP)	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
Sec1/munc18-like (SM) proteins	0	Direct
PAPS sulfotransferase	0	Direct
Ubiquitin activating enzymes (UBA)	0	Direct
NHL repeat	0	Direct
Dimeric isocitrate & isopropylmalate dehydrogenases	0	Direct
Isoprenyl diphosphate synthases	0	Direct
DEK C-terminal domain	0	Direct
RUNT domain	0	Direct
Ribonuclease PH domain 1-like	0	Direct
Formin homology 2 domain (FH2 domain)	0	Direct
Succinyl-CoA synthetase domains	0	Direct
Integrin domains	0	Direct
Eps15 homology domain (EH domain)	0	Direct
Subtilases	0	Direct
B-box zinc-binding domain	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
Inositol polyphosphate kinase (IPK)	0	Direct
ARID domain	0	Direct
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	Direct
Cell cycle transcription factor e2f-dp	0	Direct
SMAD domain	0	Direct
SMAD MH1 domain	0	Direct
Paired domain	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
RNase III catalytic domain-like	0	Direct
Translational machinery components	0	Direct
MAM domain	0	Direct
Histone lysine methyltransferases	0	Direct
HR1 repeat	0	Direct
Tandem AAA-ATPase domain	0.000135	Direct
Leucine zipper domain	0.001032	Inherited
Canonical RBD	0.002976	Inherited
Protein kinases, catalytic subunit	0.01401	Inherited
Homeodomain	0.03084	Inherited
Nuclear receptor	0.03751	Inherited
Nuclear receptor ligand-binding domain	0.06025	Inherited
Spectrin repeat	0.1021	Inherited
Motor proteins	0.1275	Inherited
EGF-type module	0.1673	Inherited
Erythroid transcription factor GATA-1	0.2812	Inherited
Zf-UBP	0.6442	Inherited

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Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
SAND domain-like	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
PriA/YqbF domain	0	Direct
DEK C-terminal domain	0	Direct
Clathrin adaptor appendage domain	0	Direct
ACP-like	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
S15/NS1 RNA-binding domain	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
Smc hinge domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
GINS helical bundle-like	0	Direct
Isocitrate/Isopropylmalate dehydrogenase-like	0	Direct
Cytokine	0	Direct
Succinyl-CoA synthetase domains	0	Direct
Formin homology 2 domain (FH2 domain)	0	Direct
RNase III domain-like	0	Direct
Class I glutamine amidotransferase-like	0	Direct
PIN domain-like	0	Direct
Class II aaRS ABD-related	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
E2F-DP heterodimerization region	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
Zn-binding ribosomal proteins	0	Direct
Tetrahydrobiopterin biosynthesis enzymes-like	0	Direct
SMAD MH1 domain	0	Direct
HR1 repeat	0	Direct
Sec1/munc18-like (SM) proteins	0	Direct
KA1-like	0	Direct
Putative DNA-binding domain	0	Direct
lambda repressor-like DNA-binding domains	0	Direct
Ferritin-like	0	Direct
Aldolase	0	Direct
ARID-like	0	Direct
Zinc beta-ribbon	0	Direct
HSP90 C-terminal domain	0	Direct
SMAD/FHA domain	0	Direct
Ribonuclease PH domain 2-like	0	Direct
B-box zinc-binding domain	0	Direct
ACT-like	0	Direct
Terpenoid synthases	0	Direct
Nop domain	0	Direct
Subtilisin-like	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
Leucine zipper domain	0.0006303	Direct
SNARE fusion complex	0.003064	Inherited
RNA-binding domain, RBD	0.006115	Inherited
ARM repeat	0.02155	Inherited
Nuclear receptor ligand-binding domain	0.05132	Inherited
Homeodomain-like	0.05577	Inherited
Protein kinase-like (PK-like)	0.06333	Inherited
beta-sandwich domain of Sec23/24	0.06456	Inherited
Spectrin repeat	0.09226	Inherited
Snake toxin-like	0.1578	Inherited
EGF/Laminin	0.4002	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	Direct
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains	0	Direct
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	Direct
57850,57850 57850 - RING/U-box 57850 - RING/U-box	0	Direct
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0	Direct
50615,52540 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0	Direct
63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT	0	Direct
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	Direct
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	Direct
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0	Direct
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0	Direct
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0	Direct
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0	Direct
57196,49854 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain	0	Direct

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
48452,48452,48452 48452 - TPR-like 48452 - TPR-like 48452 - TPR-like	0	Direct
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box	0	Direct
50615,52540,47917 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0	Direct
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.3506	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Fly Phenotype (FP): increased mortality

Superfamily

Family

Supra-domain (including individual superfamily)