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Phenotypic Abnormality (PA): Abnormality of metabolism/homeostasis
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this HP term (SDHP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Amylase, catalytic domain | 0 | DIRECT |
| Ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Gonadodropin/Follitropin | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Cystathionine synthase-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Long-chain cytokines | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Aminomethyltransferase folate-binding domain | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0.009911 | INHERITED FROM: Abnormal blood glucose concentration || Abnormal circulating carboxylic acid concentration || Acidosis || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Hypoglycemia |
| SH2 domain | 0.01377 | INHERITED FROM: Fever || Abnormality of B cell physiology || Abnormal lymphocyte physiology |
| Mitochondrial carrier | 0.04612 | INHERITED FROM: Organic aciduria || Hyperammonemia || Azotemia || Lactic acidosis |
| BC N-terminal domain-like | 0.0498 | INHERITED FROM: Hyperammonemia || Abnormal circulating carboxylic acid concentration || Azotemia || Aciduria || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Hypoglycemia || Abnormal circulating nitrogen compound concentration |
| Transcription factor STAT-4 N-domain | 0.0498 | INHERITED FROM: Fever || Abnormal urine cytology |
| Ras-binding domain, RBD | 0.0498 | INHERITED FROM: Edema |
| STAT DNA-binding domain | 0.0498 | INHERITED FROM: Fever || Abnormal urine cytology |
| STAT | 0.0498 | INHERITED FROM: Fever || Abnormal urine cytology |
| BC ATP-binding domain-like | 0.0498 | INHERITED FROM: Hyperammonemia || Abnormal circulating carboxylic acid concentration || Azotemia || Aciduria || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Hypoglycemia || Abnormal circulating nitrogen compound concentration |
| LIM domain | 0.05589 | INHERITED FROM: Abnormality of circulating enzyme level || Abnormal circulating protein level || Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration |
| DEATH domain, DD | 0.07436 | INHERITED FROM: Abnormality of B cell physiology || Abnormal immunoglobulin level |
| C1 set domains (antibody constant domain-like) | 0.07436 | INHERITED FROM: Abnormal erythrocyte sedimentation rate || Abnormality of B cell physiology || Abnormal immunoglobulin level |
| Cytochrome P450 | 0.07738 | INHERITED FROM: Abnormal urinary electrolyte concentration || Hyponatremia || Abnormal blood potassium concentration || Abnormal blood cation concentration |
| TNF receptor-like | 0.08287 | INHERITED FROM: Abnormality of B cell physiology || Abnormal cellular physiology || Abnormal immunoglobulin level |
| MHC antigen-recognition domain | 0.08287 | INHERITED FROM: Abnormal C-reactive protein level || Abnormal erythrocyte sedimentation rate || Edema |
| Ras GEF | 0.08298 | INHERITED FROM: Abnormality of fluid regulation || Edema |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0.08298 | INHERITED FROM: Abnormality of circulating enzyme level || Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration |
| Pyrin domain, PYD | 0.08298 | INHERITED FROM: Abnormality of temperature regulation || Amyloidosis || Fever |
| Arylsulfatase | 0.1203 | INHERITED FROM: Urinary glycosaminoglycan excretion |
| 28-residue LRR | 0.1203 | INHERITED FROM: Abnormal C-reactive protein level || Abnormal erythrocyte sedimentation rate || Fever |
| CBS-domain pair | 0.1203 | INHERITED FROM: Hypokalemia || Abnormal blood potassium concentration |
| RecA protein-like (ATPase-domain) | 0.1203 | INHERITED FROM: Abnormality of chromosome stability |
| TNF-like | 0.1249 | INHERITED FROM: Abnormality of B cell physiology || Increased circulating IgM level |
| Clc chloride channel | 0.1341 | INHERITED FROM: Hypokalemia || Abnormal urinary electrolyte concentration || Abnormal blood ion concentration || Abnormal blood potassium concentration |
| Pancreatic lipase, N-terminal domain | 0.1364 | INHERITED FROM: Abnormal circulating lipid concentration |
| Insulin-like | 0.1364 | INHERITED FROM: Abnormal blood glucose concentration || Hypoglycemia |
| GAF domain | 0.1364 | INHERITED FROM: Glucose intolerance || Diabetes mellitus |
| BC C-terminal domain-like | 0.1364 | INHERITED FROM: Abnormal blood glucose concentration || Abnormal circulating carboxylic acid concentration || Acidosis || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Hypoglycemia |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.1364 | INHERITED FROM: Glucose intolerance |
| Cytoplasmic domain of inward rectifier potassium channel | 0.1719 | INHERITED FROM: Hypomagnesemia || Hypokalemia || Abnormal urinary electrolyte concentration || Abnormal magnesium concentration || Metabolic alkalosis || Abnormal blood potassium concentration || Abnormal blood monovalent inorganic cation concentration || Abnormal blood cation concentration || Alkalosis |
| FAD-linked reductases, N-terminal domain | 0.2002 | INHERITED FROM: Abnormal circulating carboxylic acid concentration |
| Crotonase-like | 0.2002 | INHERITED FROM: Abnormality of the mitochondrion || Aciduria || Acidosis || Abnormality of acid-base homeostasis || Abnormality of mitochondrial metabolism || Aminoaciduria |
| Noncollagenous (NC1) domain of collagen IV | 0.2002 | INHERITED FROM: Proteinuria || Abnormal urine cytology || Hematuria |
| Tropomyosin | 0.2424 | INHERITED FROM: Abnormality of circulating enzyme level || Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration |
| PDEase | 0.2424 | INHERITED FROM: Glucose intolerance || Diabetes mellitus |
| Caspase recruitment domain, CARD | 0.2953 | INHERITED FROM: Fever |
| Phosphotyrosine-binding domain (PTB) | 0.3624 | INHERITED FROM: Insulin resistance |
| Complement control module/SCR domain | 0.4296 | INHERITED FROM: Increased lactate dehydrogenase activity || Elevated serum creatinine || Abnormal lactate dehydrogenase activity || Increased blood urea nitrogen || Abnormal blood urea nitrogen concentration || Abnormal circulating creatinine level || Azotemia || Generalized edema || Abnormal urine cytology || Abnormal circulating nitrogen compound concentration |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.4811 | INHERITED FROM: Acidosis || Abnormality of acid-base homeostasis |
| Fibrinogen C-terminal domain-like | 0.4811 | INHERITED FROM: Joint swelling |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.5012 | INHERITED FROM: Acidosis || Abnormality of acid-base homeostasis |
| Eukaryotic proteases | 0.5126 | INHERITED FROM: Type I diabetes mellitus || Elevated serum creatinine || Abnormal circulating creatinine level |
| Extended AAA-ATPase domain | 0.5836 | INHERITED FROM: Abnormal tissue metabolite concentration |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.7368 | INHERITED FROM: Increased serum lactate || Abnormality of acid-base homeostasis |
| G proteins | 0.8151 | INHERITED FROM: Lymphedema |
| Canonical RBD | 0.9123 | INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration |
| Ngr ectodomain-like | 0.9248 | INHERITED FROM: Macroscopic hematuria |
| Voltage-gated potassium channels | 0.9841 | INHERITED FROM: Hypomagnesemia || Hypokalemia || Abnormal magnesium concentration || Metabolic alkalosis || Abnormal blood potassium concentration || Abnormal blood monovalent inorganic cation concentration |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: Malignant hyperthermia |
| Nicotinic receptor ligand binding domain-like | 1 | INHERITED FROM: Malignant hyperthermia |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Amylase, catalytic domain | 0 | Direct |
| Ferredoxin domains from multidomain proteins | 0 | Direct |
| Gonadodropin/Follitropin | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| beta-glycanases | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| FAD/NAD-linked reductases, N-terminal and central domains | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Cystathionine synthase-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| Long-chain cytokines | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Phosphoribosyltransferases (PRTases) | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Aminomethyltransferase folate-binding domain | 0 | Direct |
| IF2B-like | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0.009911 | Inherited |
| SH2 domain | 0.01377 | Inherited |
| Mitochondrial carrier | 0.04612 | Inherited |
| BC N-terminal domain-like | 0.0498 | Inherited |
| Transcription factor STAT-4 N-domain | 0.0498 | Inherited |
| Ras-binding domain, RBD | 0.0498 | Inherited |
| STAT DNA-binding domain | 0.0498 | Inherited |
| STAT | 0.0498 | Inherited |
| BC ATP-binding domain-like | 0.0498 | Inherited |
| LIM domain | 0.05589 | Inherited |
| DEATH domain, DD | 0.07436 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.07436 | Inherited |
| Cytochrome P450 | 0.07738 | Inherited |
| TNF receptor-like | 0.08287 | Inherited |
| MHC antigen-recognition domain | 0.08287 | Inherited |
| Ras GEF | 0.08298 | Inherited |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0.08298 | Inherited |
| Pyrin domain, PYD | 0.08298 | Inherited |
| Arylsulfatase | 0.1203 | Inherited |
| 28-residue LRR | 0.1203 | Inherited |
| CBS-domain pair | 0.1203 | Inherited |
| RecA protein-like (ATPase-domain) | 0.1203 | Inherited |
| TNF-like | 0.1249 | Inherited |
| Clc chloride channel | 0.1341 | Inherited |
| Pancreatic lipase, N-terminal domain | 0.1364 | Inherited |
| Insulin-like | 0.1364 | Inherited |
| GAF domain | 0.1364 | Inherited |
| BC C-terminal domain-like | 0.1364 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.1364 | Inherited |
| Cytoplasmic domain of inward rectifier potassium channel | 0.1719 | Inherited |
| FAD-linked reductases, N-terminal domain | 0.2002 | Inherited |
| Crotonase-like | 0.2002 | Inherited |
| Noncollagenous (NC1) domain of collagen IV | 0.2002 | Inherited |
| Tropomyosin | 0.2424 | Inherited |
| PDEase | 0.2424 | Inherited |
| Caspase recruitment domain, CARD | 0.2953 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.3624 | Inherited |
| Complement control module/SCR domain | 0.4296 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.4811 | Inherited |
| Fibrinogen C-terminal domain-like | 0.4811 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.5012 | Inherited |
| Eukaryotic proteases | 0.5126 | Inherited |
| Extended AAA-ATPase domain | 0.5836 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.7368 | Inherited |
| G proteins | 0.8151 | Inherited |
| Canonical RBD | 0.9123 | Inherited |
| Ngr ectodomain-like | 0.9248 | Inherited |
| Voltage-gated potassium channels | 0.9841 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
| Nicotinic receptor ligand binding domain-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this HP term (SPHO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
57424,49854
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0 | DIRECT |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.02639 | INHERITED FROM: Abnormality of acid-base homeostasis || Acidosis |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.03224 | INHERITED FROM: Abnormality of B cell physiology || Abnormal immunoglobulin level || Abnormal cellular physiology |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.04513 | INHERITED FROM: Abnormal urine cytology || Fever |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04513 | INHERITED FROM: Abnormal urine cytology || Fever |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.04513 | INHERITED FROM: Abnormal urine cytology || Fever |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.05136 | INHERITED FROM: Abnormality of B cell physiology || Abnormal immunoglobulin level |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.06541 | INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.07407 | INHERITED FROM: Abnormal erythrocyte sedimentation rate || Edema || Abnormal C-reactive protein level |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0.07631 | INHERITED FROM: Hypoglycemia || Abnormal blood glucose concentration |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.07631 | INHERITED FROM: Abnormal erythrocyte sedimentation rate || Abnormality of temperature regulation || Abnormal C-reactive protein level || Fever |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.1287 | INHERITED FROM: Diabetes mellitus || Glucose intolerance |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1287 | INHERITED FROM: Glucose intolerance |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.1287 | INHERITED FROM: Hypoglycemia || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Acidosis || Abnormal circulating carboxylic acid concentration || Abnormal blood glucose concentration |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0.1287 | INHERITED FROM: Diabetes mellitus || Glucose intolerance |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0.1587 | INHERITED FROM: Abnormal magnesium concentration || Hypomagnesemia || Alkalosis || Abnormal blood cation concentration || Abnormal blood potassium concentration || Abnormal blood monovalent inorganic cation concentration || Hypokalemia || Metabolic alkalosis || Abnormal urinary electrolyte concentration |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.1587 | INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration || Abnormal circulating protein level || Abnormality of circulating enzyme level |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0.2266 | INHERITED FROM: Hyperammonemia || Azotemia || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Abnormal circulating carboxylic acid concentration || Abnormal circulating nitrogen compound concentration |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.2266 | INHERITED FROM: Abnormal circulating carboxylic acid concentration |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.2805 | INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration || Mildly elevated creatine kinase || Abnormality of circulating enzyme level |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.3144 | INHERITED FROM: Azotemia || Increased blood urea nitrogen || Abnormal urine cytology || Elevated serum creatinine || Increased lactate dehydrogenase activity || Abnormal circulating creatinine level || Abnormal blood urea nitrogen concentration || Abnormal circulating nitrogen compound concentration || Generalized edema || Abnormal lactate dehydrogenase activity |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.4487 | INHERITED FROM: Abnormal urine cytology || Hematuria |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9925 | INHERITED FROM: Malignant hyperthermia |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
57424,49854
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | Direct |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0 | Direct |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.02639 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.03224 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.04513 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04513 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.04513 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.05136 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.06541 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.07407 | Inherited |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0.07631 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.07631 | Inherited |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.1287 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1287 | Inherited |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.1287 | Inherited |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0.1287 | Inherited |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0.1587 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.1587 | Inherited |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0.2266 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.2266 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.2805 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.3144 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.4487 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9925 | Inherited |
(show details)
Supra-domains annotated to this HP term (SPHO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.01528 | INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration || Abnormal circulating protein level || Abnormality of circulating enzyme level |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.03224 | INHERITED FROM: Hyperlipidemia || Azotemia || Increased blood urea nitrogen || Abnormal urine cytology || Elevated serum creatinine || Abnormal circulating creatinine level || Abnormal blood urea nitrogen concentration || Abnormal circulating nitrogen compound concentration || Generalized edema |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.04513 | INHERITED FROM: Abnormal urine cytology || Fever |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04513 | INHERITED FROM: Abnormal urine cytology || Fever |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.08049 | INHERITED FROM: Type II diabetes mellitus |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.09414 | INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.1246 | INHERITED FROM: Type II diabetes mellitus |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.1287 | INHERITED FROM: Hypoglycemia || Abnormality of serum amino acid level || Abnormality of acid-base homeostasis || Acidosis || Abnormal circulating carboxylic acid concentration || Abnormal blood glucose concentration |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.1287 | INHERITED FROM: Diabetes mellitus || Glucose intolerance |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.01528 | Inherited |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.03224 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.04513 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.04513 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.08049 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.09414 | Inherited |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.1246 | Inherited |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.1287 | Inherited |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.1287 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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