Phenotypic Abnormality (PA): EEG with generalized epileptiform discharges

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children)	HP term [HP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + + + + + 8:	Phenotypic abnormality [HP:0000118] <25>
+ + + + + + + 7:	Abnormality of the nervous system [HP:0000707] <4>	(142|168)	(156|103|45)
+ + + + + + 6:	Abnormality of nervous system physiology [HP:0012638] <26>	(101|119)	(112|81|39)
+ + + + + 5:	Abnormal nervous system electrophysiology [HP:0001311] <2>	(8|10)	(10|2|0)
+ + + + 4:	Abnormality of central nervous system electrophysiology [HP:0030178] <5>	(7|8)	(9|2|0)
+ + + 3:	EEG abnormality [HP:0002353] <6>	(7|8)	(9|2|0)
+ + 2:	Interictal EEG abnormality [HP:0025373] <5>	(6|8)	(8|2|0)
+ 1:	Interictal epileptiform activity [HP:0011182] <3>	(6|8)	(8|2|0)
0:	EEG with generalized epileptiform discharges [HP:0011198] <7>	(6|8)	(7|2|0)
- 1:	EEG with spike-wave complexes [HP:0010850] <5>	(1|4)	(1|0|0)
- 1:	EEG with generalized polymorphic epileptiform discharges [HP:0011200] <1>	(0|0)	(0|0|0)
- 1:	EEG with burst suppression [HP:0010851]	(0|0)	(0|0|0)
- 1:	EEG with generalized polyspikes [HP:0012001]	(0|0)	(0|0|0)
- 1:	EEG with generalized sharp slow waves [HP:0011199]	(0|0)	(0|0|0)
- 1:	EEG with generalized spikes [HP:0012000]	(0|0)	(0|0|0)
- 1:	Hypsarrhythmia [HP:0002521]	(0|1)	(1|0|0)

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Superfamily

Superfamily domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Voltage-gated potassium channels	0.000000001595	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0003341	DIRECT
Nicotinic receptor ligand binding domain-like	0.0003341	DIRECT
SNARE fusion complex	0.000497	DIRECT
Periplasmic binding protein-like I	0.0007222	DIRECT
Periplasmic binding protein-like II	0.0008921	DIRECT

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Family

Family domains annotated to this HP term (Not in SDHP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Glycosyl transferases group 1	0	DIRECT
Voltage-gated potassium channels	0.00006597	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0001453	DIRECT
Nicotinic receptor ligand binding domain-like	0.0001453	DIRECT
SNARE fusion complex	0.0002377	DIRECT
Phosphate binding protein-like	0.0002378	DIRECT
L-arabinose binding protein-like	0.001549	INHERITED FROM: Hypsarrhythmia
Nucleotide and nucleoside kinases	0.02631	INHERITED FROM: EEG with spike-wave complexes

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Supra-domain (including individual superfamily)

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Voltage-gated potassium channels	0.000000000608	DIRECT
Nicotinic receptor ligand binding domain-like	0.0001654	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0001654	DIRECT
SNARE fusion complex	0.0002509	DIRECT
Periplasmic binding protein-like I	0.0003737	DIRECT
Periplasmic binding protein-like II	0.0004693	DIRECT
Translation proteins	0.002431	INHERITED FROM: Hypsarrhythmia

Supra-domains annotated to this HP term (SPHO level: Highly Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53822,53850 53822 - Periplasmic binding protein-like I 53850 - Periplasmic binding protein-like II	0.00005893	DIRECT
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.0001654	DIRECT