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Phenotypic Abnormality (PA): Abnormality of the pituitary gland

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ + + 3:   Abnormality of nervous system morphology [HP:0012639] <5>(69|97) (79|52|16)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Morphological abnormality of the central nervous system [HP:0002011] <17>(60|85) (69|44|16)
+ + 2:   Abnormality of the endocrine system [HP:0000818] <16>(28|35) (35|13|5)
+ 1:   Abnormality of brain morphology [HP:0012443] <13>(43|63) (53|34|15)
+ 1:   Abnormality of the hypothalamus-pituitary axis [HP:0000864] <2>(6|7) (7|2|0)
0:   Abnormality of the pituitary gland [HP:0012503] <5>(6|7) (7|2|0)
- 1:   Abnormality of the anterior pituitary [HP:0011747] <7>(6|7) (7|2|0)
- 1:   Abnormality of the posterior pituitary [HP:0011751] <3>(1|1) (1|0|0)
- 1:   Abnormal size of pituitary gland [HP:0012504] <2>(0|0) (0|0|0)
- 1:   Abnormal thyroid-stimulating hormone level [HP:0031097] <2>(0|0) (0|0|0)
- 1:   Prolactinoma [HP:0040278](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nuclear receptor ligand-binding domain0.001591Inherited
Homeodomain-like0.001672Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.002667Inherited
p53-like transcription factors0.009249Inherited
Ribosomal protein S5 domain 2-like0.1126Inherited
Cytochrome P4500.1633Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, second domain0.00001532Direct
DNA gyrase/MutL, N-terminal domain0.00001532Direct
Nuclear receptor ligand-binding domain0.001275Inherited
Homeodomain0.002367Inherited
Nuclear receptor0.00386Inherited
Tyrosine-dependent oxidoreductases0.05467Inherited
Cytochrome P4500.1396Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nuclear receptor ligand-binding domain0.0008732Direct
Homeodomain-like0.0009217Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.001529Inherited
p53-like transcription factors0.005918Inherited
HMG-box0.01166Inherited
Ribosomal protein S5 domain 2-like0.08903Inherited
Cytochrome P4500.1339Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.00001022Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.03299Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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