Phenotypic Abnormality (PA): Abnormality of the mouth

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + 4: Phenotypic abnormality [HP:0000118] <25>

+ + + 3: Abnormality of head or neck [HP:0000152] <2> (86|104) (97|58|38)

+ + 2: Abnormality of the head [HP:0000234] <6> (85|102) (96|57|38)

+ 1: Abnormality of the face [HP:0000271] <14> (70|85) (82|46|31)

0: Abnormality of the mouth [HP:0000153] <2> (37|57) (46|32|22)

- 1: Abnormal oral physiology [HP:0031815] <7> (2|3) (2|1|1)

- 1: Abnormal oral morphology [HP:0031816] <6> (35|53) (44|30|21)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Tricorn protease domain 2	0	Direct
TB module/8-cys domain	0	Direct
CalX-like	0	Direct
Plakin repeat	0	Direct
Helical domain of Sec23/24	0	Direct
Integrin beta tail domain	0	Direct
Smc hinge domain	0	Direct
Fibrinogen coiled-coil and central regions	0	Direct
Zn-finger domain of Sec23/24	0	Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	Direct
Actin depolymerizing proteins	0	Direct
Tudor/PWWP/MBT	0.0004561	Direct
HMG-box	0.01356	Inherited
ARID-like	0.03392	Inherited
RNA-binding domain, RBD	0.08952	Inherited
Notch domain	0.1083	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1083	Inherited
Calcium-dependent phosphotriesterase	0.1083	Inherited
Homeodomain-like	0.1421	Inherited
Hect, E3 ligase catalytic domain	0.1623	Inherited
MHC antigen-recognition domain	0.2655	Inherited
Bromodomain	0.2724	Inherited
RNI-like	0.3136	Inherited
Ubiquitin-like	0.3191	Inherited
Fibrinogen C-terminal domain-like	0.3601	Inherited
SMAD/FHA domain	0.3864	Inherited
BRK domain-like	0.4863	Inherited
MIR domain	0.4935	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.5077	Inherited
Immunoglobulin	0.7307	Inherited
Transcription factor STAT-4 N-domain	0.7578	Inherited
STAT	0.7578	Inherited
4-helical cytokines	0.7934	Inherited
Intermediate filament protein, coiled coil region	0.8097	Inherited
DEATH domain	0.9122	Inherited
Trypsin-like serine proteases	0.9839	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Zn-finger domain of Sec23/24	0	Direct
CalX-beta domain	0	Direct
Armadillo repeat	0	Direct
Protein serine/threonine phosphatase	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Helical domain of Sec23/24	0	Direct
Serum paraoxonase/arylesterase 1, PON1	0	Direct
Interleukin-1 (IL-1)	0	Direct
Clathrin adaptor core protein	0	Direct
Glycosyl transferases group 1	0	Direct
Integrin beta EGF-like domains	0	Direct
Smc hinge domain	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Histone deacetylase, HDAC	0	Direct
Plakin repeat	0	Direct
Ferredoxin reductase FAD-binding domain-like	0	Direct
TB module/8-cys domain	0	Direct
beta-sandwich domain of Sec23/24	0	Direct
Trunk domain of Sec23/24	0	Direct
Fibrinogen coiled-coil and central regions	0	Direct
PWWP domain	0	Direct
Integrin beta tail domain	0	Direct
HMG-box	0.009842	Inherited
PX domain	0.01314	Inherited
ARID domain	0.02536	Inherited
Laminin-type module	0.04461	Inherited
SPRY domain	0.04825	Inherited
Pyrin domain, PYD	0.04825	Inherited
VWC domain	0.07598	Inherited
Notch domain	0.08929	Inherited
DIX domain	0.08929	Inherited
Hect, E3 ligase catalytic domain	0.142	Inherited
RecA protein-like (ATPase-domain)	0.1591	Inherited
Canonical RBD	0.1617	Inherited
Homeodomain	0.1617	Inherited
C1 set domains (antibody constant domain-like)	0.1726	Inherited
Fibroblast growth factors (FGF)	0.1726	Inherited
GLA-domain	0.2241	Inherited
PDZ domain	0.2304	Inherited
T-box	0.236	Inherited
MHC antigen-recognition domain	0.2365	Inherited
Bromodomain	0.2492	Inherited
28-residue LRR	0.2542	Inherited
Fibrinogen C-terminal domain-like	0.3272	Inherited
PHD domain	0.335	Inherited
Histone lysine methyltransferases	0.3885	Inherited
Clathrin coat assembly domain	0.4568	Inherited
BRK domain-like	0.4568	Inherited
beta-glycanases	0.4568	Inherited
MIR domain	0.4608	Inherited
Tetratricopeptide repeat (TPR)	0.5506	Inherited
Transcription factor STAT-4 N-domain	0.7386	Inherited
STAT DNA-binding domain	0.7386	Inherited
STAT	0.7386	Inherited
Intermediate filament protein, coiled coil region	0.8025	Inherited
PLC-like (P variant)	0.8081	Inherited
Eukaryotic proteases	0.9505	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Smc hinge domain	0	Direct
CalX-like	0	Direct
Fibrinogen coiled-coil and central regions	0	Direct
Plakin repeat	0	Direct
Tricorn protease domain 2	0	Direct
TB module/8-cys domain	0	Direct
Helical domain of Sec23/24	0	Direct
Actin depolymerizing proteins	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Integrin beta tail domain	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	Direct
Tudor/PWWP/MBT	0.0002293	Direct
HMG-box	0.008947	Inherited
PX domain	0.01233	Inherited
ARID-like	0.02408	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.04569	Inherited
Actin-like ATPase domain	0.0588	Inherited
RNA-binding domain, RBD	0.06959	Inherited
Notch domain	0.08537	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.08537	Inherited
Calcium-dependent phosphotriesterase	0.08537	Inherited
Cytokine	0.08835	Inherited
Homeodomain-like	0.1155	Inherited
Hect, E3 ligase catalytic domain	0.1332	Inherited
EGF/Laminin	0.1736	Inherited
DPP6 N-terminal domain-like	0.1991	Inherited
GLA-domain	0.2165	Inherited
Glycosyl hydrolase domain	0.2244	Inherited
MHC antigen-recognition domain	0.2276	Inherited
Bromodomain	0.2343	Inherited
RNI-like	0.273	Inherited
Ubiquitin-like	0.2785	Inherited
Fibrinogen C-terminal domain-like	0.3178	Inherited
SMAD/FHA domain	0.3432	Inherited
SET domain	0.4089	Inherited
BRK domain-like	0.4424	Inherited
MIR domain	0.4491	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.4634	Inherited
Immunoglobulin	0.6926	Inherited
Transcription factor STAT-4 N-domain	0.7209	Inherited
STAT	0.7209	Inherited
4-helical cytokines	0.7579	Inherited
Intermediate filament protein, coiled coil region	0.775	Inherited
DEATH domain	0.8838	Inherited
Trypsin-like serine proteases	0.9618	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
75399,75399 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	Direct
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	Direct
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
57889,48350 57889 - Cysteine-rich domain 48350 - GTPase activation domain, GAP	0	Direct
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	Direct
64268,50044 64268 - PX domain 50044 - SH3-domain	0	Direct
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	Direct
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24	0	Direct
141072,141072 141072 - CalX-like 141072 - CalX-like	0	Direct
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0	Direct
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24	0	Direct
53300,69179 53300 - vWA-like 69179 - Integrin domains	0	Direct
57184,57581 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
54928,90209 54928 - RNA-binding domain, RBD 90209 - Ran binding protein zinc finger-like	0	Direct
57581,57184 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.08537	Inherited
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.08908	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1317	Inherited
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.2244	Inherited
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain	0.2244	Inherited
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.2276	Inherited
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0.2964	Inherited
55486,82895 55486 - Metalloproteases ("zincins"), catalytic domain 82895 - TSP-1 type 1 repeat	0.4424	Inherited
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.4424	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.6857	Inherited
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0.7209	Inherited
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0.7209	Inherited
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0.7209	Inherited
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region	0.8196	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57581,57196 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	Direct
57184,57581,57196 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	Direct
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24	0	Direct
57196,57196,57581 57196 - EGF/Laminin 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	Direct
141072,141072,141072 141072 - CalX-like 141072 - CalX-like 141072 - CalX-like	0	Direct
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	Direct
57581,57196,57581 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	Direct
57184,57184,57581 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
63825,57196,63825 63825 - YWTD domain 57196 - EGF/Laminin 63825 - YWTD domain	0	Direct
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0	Direct
57184,57581,57184 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
57196,57581,57184 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	Direct
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0	Direct
57581,57184,57581 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	Direct
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	Direct
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.08537	Inherited
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1668	Inherited
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.2426	Inherited
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.4925	Inherited
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0.7209	Inherited
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0.7209	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Phenotypic Abnormality (PA): Abnormality of the mouth

Superfamily

Family

Supra-domain (including individual superfamily)