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Phenotypic Abnormality (PA): Macrocephaly

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Abnormality of the skeletal system [HP:0000924] <7>(88|98) (93|55|34)
+ + + + + + 6:   Phenotypic abnormality [HP:0000118] <25>
+ + + + + 5:   Abnormality of head or neck [HP:0000152] <2>(86|104) (97|58|38)
+ + + + + 5:   Abnormality of skeletal morphology [HP:0011842] <17>(86|89) (90|52|33)
+ + + + 4:   Abnormal axial skeleton morphology [HP:0009121] <6>(47|61) (51|30|26)
+ + + + 4:   Abnormality of the head [HP:0000234] <6>(85|102) (96|57|38)
+ + + 3:   Abnormal skull morphology [HP:0000929] <14>(25|38) (28|22|20)
+ + 2:   Abnormality of skull size [HP:0000240] <2>(14|23) (15|11|5)
+ 1:   Increased head circumference [HP:0040194] <1>(3|5) (3|5|4)
0:   Macrocephaly [HP:0000256] <4>(3|5) (3|5|4)
- 1:   Macrocephaly at birth [HP:0004488](0|0) (0|0|0)
- 1:   Postnatal macrocephaly [HP:0005490](0|0) (0|0|0)
- 1:   Progressive macrocephaly [HP:0004481](0|0) (0|0|0)
- 1:   Relative macrocephaly [HP:0004482](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nucleotide-diphospho-sugar transferases0.00007654Direct
C-terminal, gelsolin-like domain of Sec23/240.0009023Direct
Helical domain of Sec23/240.0009023Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
IF2B-like0Direct
C-terminal, gelsolin-like domain of Sec23/240.000541Direct
Helical domain of Sec23/240.000541Direct
beta-sandwich domain of Sec23/240.000541Direct
Trunk domain of Sec23/240.000541Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nucleotide-diphospho-sugar transferases0.00003488Direct
Helical domain of Sec23/240.0004752Direct
C-terminal, gelsolin-like domain of Sec23/240.0004752Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.000233Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000233Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0004752Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000233Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000233Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)