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Phenotypic Abnormality (PA): Abnormal peripheral nervous system morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ 1:   Abnormality of nervous system morphology [HP:0012639] <5>(69|97) (79|52|16)
0:   Abnormal peripheral nervous system morphology [HP:0000759] <14>(14|17) (18|6|0)
- 1:   Peripheral neuropathy [HP:0009830] <17>(7|11) (9|4|0)
- 1:   Abnormal cranial nerve morphology [HP:0001291] <10>(2|1) (2|1|0)
- 1:   Abnormality of peripheral nerves [HP:0045010] <10>(1|1) (1|0|0)
- 1:   Abnormal peripheral myelination [HP:0003130] <8>(0|2) (1|0|0)
- 1:   Neoplasm of the peripheral nervous system [HP:0100007] <6>(0|0) (0|0|0)
- 1:   Peripheral axonal degeneration [HP:0000764] <6>(0|0) (0|0|0)
- 1:   Abnormal anterior horn cell morphology [HP:0006802] <1>(0|0) (0|0|0)
- 1:   Neuritis [HP:0031002] <1>(0|0) (0|0|0)
- 1:   Abnormal lower motor neuron morphology [HP:0002366](0|1) (1|0|0)
- 1:   Decreased size of nerve terminals [HP:0003443](2|2) (2|1|0)
- 1:   Diffuse axonal swelling [HP:0003405](0|0) (0|0|0)
- 1:   Enhanced neurotoxicity of vincristine [HP:0003009](0|0) (0|0|0)
- 1:   Hypertrophic nerve changes [HP:0003382](0|0) (0|0|0)
- 1:   Minifascicle formation [HP:0031001](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Actin depolymerizing proteins0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0009587Direct
MHC antigen-recognition domain0.002444Inherited
S15/NS1 RNA-binding domain0.02787Inherited
PH domain-like0.03739Inherited
Kelch motif0.04628Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.132Inherited
Voltage-gated potassium channels0.1831Inherited
Class II aaRS and biotin synthetases0.19Inherited
Glycosyl hydrolase domain0.2112Inherited
Ribonuclease H-like0.2601Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2796Inherited
Nicotinic receptor ligand binding domain-like0.2796Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Myotubularin-like phosphatases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Smc hinge domain0Direct
MHC antigen-recognition domain0.00138Inherited
C1 set domains (antibody constant domain-like)0.002006Inherited
a tRNA synthase domain0.01989Inherited
DNA gyrase/MutL, second domain0.01989Inherited
DNA gyrase/MutL, N-terminal domain0.01989Inherited
Amylase, catalytic domain0.02422Inherited
Kelch motif0.03497Inherited
Transducin (alpha subunit), insertion domain0.07655Inherited
FHA domain0.1084Inherited
Extended AAA-ATPase domain0.1612Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.1804Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2386Inherited
Nicotinic receptor ligand binding domain-like0.2386Inherited
Canonical RBD0.6276Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Actin depolymerizing proteins0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0005077Direct
MHC antigen-recognition domain0.001395Inherited
S15/NS1 RNA-binding domain0.01946Inherited
PH domain-like0.0268Inherited
Kelch motif0.03378Inherited
Transducin (alpha subunit), insertion domain0.07643Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.1065Inherited
Voltage-gated potassium channels0.1516Inherited
Class II aaRS and biotin synthetases0.1581Inherited
Glycosyl hydrolase domain0.1777Inherited
Ribonuclease H-like0.2225Inherited
Nicotinic receptor ligand binding domain-like0.241Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.241Inherited
SMAD/FHA domain0.4301Inherited
RNA-binding domain, RBD0.4646Inherited
Ribosomal protein S5 domain 2-like0.561Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.001395Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.002029Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01946Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07643Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1777Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.241Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)